keyword
https://read.qxmd.com/read/38321911/mutational-analysis-of-consanguineous-families-and-their-targeted-therapy-against-dwarfism
#21
JOURNAL ARTICLE
Feroz Khan, Sarmir Khan, Nehal Rana, Tariq Rahim, Abida Arshad, Imtiaz Khan, Hanan A Ogaly, Dalia Abd El Moneim Ahmed, Ayed A Dera, Sumera Zaib
Dwarfism is a medical term used to describe individuals with a height-vertex measurement that falls below two standard deviations (-2SD) or the third percentile for their gender and age. Normal development of growth is a complicated dynamic procedure that depends upon the coordination of different aspects involving diet, genetics, and biological aspects like hormones in equilibrium. Any severe or acute pathologic procedure may disturb the individual's normal rate of growth. In this research, we examined four (A-D) Pakistani consanguineous families that exhibited syndromic dwarfism, which was inherited in an autosomal recessive pattern...
February 7, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38299297/structure-activity-relationship-studies-on-vegfr2-tyrosine-kinase-inhibitors-for-identification-of-potential-natural-anticancer-compounds
#22
JOURNAL ARTICLE
Meenakshi Verma, Inamul Hasan, Feroz Khan, Prema G Vasudev
BACKGROUND: Over-expression of vascular endothelial growth factor receptors (VEGFRs) leads to the hyperactivation of oncogenes. For inhibition of this hyperactivation, the USA Food Drug Administration (FDA) has approved many drugs that show adverse effects, such as hypertension, hypothyroidism, etc. There is a need to discover potent natural compounds that show minimal side effects. In the present study, we have taken structurally diverse known VEGFR2 inhibitors to develop a quantitative structure-activity relationship (QSAR) model and used this model to predict the inhibitory activity of natural compounds for VEGFR2...
January 29, 2024: Medicinal Chemistry
https://read.qxmd.com/read/38299014/treatment-effects-of-n-acetyl-cysteine-on-resting-state-functional-mri-and-cognitive-performance-in-patients-with-chronic-mild-traumatic-brain-injury-a-longitudinal-study
#23
JOURNAL ARTICLE
Faezeh Vedaei, Andrew B Newberg, Mahdi Alizadeh, George Zabrecky, Emily Navarreto, Chloe Hriso, Nancy Wintering, Feroze B Mohamed, Daniel Monti
Mild traumatic brain injury (mTBI) is a significant public health concern, specially characterized by a complex pattern of abnormal neural activity and functional connectivity. It is often associated with a broad spectrum of short-term and long-term cognitive and behavioral symptoms including memory dysfunction, headache, and balance difficulties. Furthermore, there is evidence that oxidative stress significantly contributes to these symptoms and neurophysiological changes. The purpose of this study was to assess the effect of N-acetylcysteine (NAC) on brain function and chronic symptoms in mTBI patients...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38278014/assessment-of-water-quality-of-netravathi-gurupur-estuary-india-through-chemometric-approach-for-fisheries-sustainability
#24
JOURNAL ARTICLE
Sonalika Sahoo, Ajoy Saha, M E Vijaykumar, M Feroz Khan, S Samanta, Sibina S Mol, B K Das
The present study aimed to assess the water quality dynamics (physicochemical properties, nutrient and chlorophyll-a) in the Netravathi-Gurupur estuary, India across the space and seasons and to simplify the complex water quality dataset through a chemometric approach. The results indicated that pH, EC, temperature, alkalinity, salinity, TDS, hardness, chloride and intense mixing of suspended solids, driven by the semidiurnal tides, are the major factors affecting water quality. Spatial heterogeneity and monsoon have profound impact on nutrient distribution revealing the following values (mg l-1 ): phosphate-P (0...
January 25, 2024: Marine Pollution Bulletin
https://read.qxmd.com/read/38269210/isotretinoin-induced-dyslipidemia-a-single-center-study-in-saudi-arabia
#25
JOURNAL ARTICLE
Mahdi Al Dhafiri, Feroze Kaliyadan, Sara Almukhaimar, Fatemah Abdulrahman Alsultan, Elham Al Hayim, Roaa Alnaim, Alaa Aldossari
PURPOSE: Acne is a chronic inflammatory skin disease with a high prevalence in Saudi Arabia. Isotretinoin is used to treat severe, resistant nodulocystic acne. Side effects include joint discomfort, headache, mucosal dryness, and nose bleeds. Elevated lipids and liver enzymes have also been recorded. The study goal is to identify the prevalence of increased lipid levels during and after isotretinoin use. PATIENTS AND METHODS: This retrospective study was conducted in the dermatology polyclinic at King Faisal University, Al-Ahsa, Saudi Arabia...
2024: Patient Preference and Adherence
https://read.qxmd.com/read/38267285/percutaneous-left-atrial-appendage-occlusion-in-mitral-valve-disease-a-nationwide-readmission-database-analysis
#26
JOURNAL ARTICLE
Rafey Feroze, Waqas Ullah, Puneet Kang, Tabitha Lobo, Nawaf Alhabdan, Mohammed Alghammass, Sung-Han Yoon, Luis Augusto Palma Dallan, Steven J Filby
BACKGROUND: Percutaneous left atrial appendage occlusion (LAAO) has emerged as a non-pharmacologic alternative to oral anticoagulation in reducing stroke risk in AF patients. However, patients with mitral valve disease (MVD), who are expected to have a significantly greater risk of left atrium (LA) thrombus formation and embolic stroke were excluded from randomized trials examining percutaneous LAAO. To address this gap, we present a national registry analysis of the use of LAAO among patients with MVD...
January 15, 2024: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://read.qxmd.com/read/38249324/exploring-functional-connectivity-in-chronic-spinal-cord-injury-patients-with-neuropathic-pain-versus-without-neuropathic-pain
#27
JOURNAL ARTICLE
Shreya Mandloi, Mashaal Syed, Isaiah Ailes, Omid Shoraka, Benjamin Leiby, Jingya Miao, Sara Thalheimer, Joshua Heller, Feroze B Mohamed, Ashwini Sharan, James Harrop, Laura Krisa, Mahdi Alizadeh
The great majority of spinal cord injury (SCI) patients have debilitating chronic pain. Despite decades of research, these pain pathways of neuropathic pain (NP) are unknown. SCI patients have been shown to have abnormal brain pain pathways. We hypothesize that SCI NP patients' pain matrix is altered compared to SCI patients without NP. This study examines the functional connectivity (FC) in SCI patients with moderate-severe chronic NP compared to SCI patients with mild-no NP. These groups were compared to control subjects...
2024: Neurotrauma reports
https://read.qxmd.com/read/38235904/supar-biomarkers-of-inflammation-and-severe-outcomes-in-patients-hospitalized-for-covid-19-the-international-study-of-inflammation-in-covid-19
#28
JOURNAL ARTICLE
Alexi Vasbinder, Kishan Padalia, Ian Pizzo, Kristen Machado, Tonimarie Catalan, Feriel Presswalla, Elizabeth Anderson, Anis Ismail, Christina Hutten, Yiyuan Huang, Pennelope Blakely, Tariq U Azam, Hanna Berlin, Rafey Feroze, Christopher Launius, Chelsea Meloche, Erinleigh Michaud, Patrick O'Hayer, Michael Pan, Husam R Shadid, Line Jee Hartmann Rasmussen, Donald A Roberts, Lili Zhao, Mousumi Banerjee, Venkatesh Murthy, Sven H Loosen, Athanasios Chalkias, Frank Tacke, Jochen Reiser, Evangelos J Giamarellos-Bourboulis, Jesper Eugen-Olsen, Rodica Pop-Busui, Salim S Hayek
Severe coronavirus disease 2019 (COVID-19) is a hyperinflammatory syndrome. The biomarkers of inflammation best suited to triage patients with COVID-19 are unknown. We conducted a prospective multicenter observational study of adult patients hospitalized specifically for COVID-19 from February 1, 2020 to October 19, 2022. Biomarkers measured included soluble urokinase plasminogen activator receptor (suPAR), C-reactive protein, interleukin-6, procalcitonin, ferritin, and D-dimer. In-hospital outcomes examined include death and the need for mechanical ventilation...
January 2024: Journal of Medical Virology
https://read.qxmd.com/read/38220517/a-multidisciplinary-protocolized-approach-for-ruptured-abdominal-aortic-aneurysm-management-a-retrospective-before-after-study
#29
JOURNAL ARTICLE
Rayaan A Yunus, Shirin Saeed, Nadav Levy, Raffaele Di Fenza, Aidan Sharkey, Susan Pobywajlo, Patric Liang, Marc Schermerhorn, Feroze Mahmood, Robina Matyal, Sara Neves
OBJECTIVES: To investigate whether implementation of a multidisciplinary protocol for ruptured abdominal aortic aneurysm (rAAA) management reduces rates of adverse complications. DESIGN: A retrospective before-after study. SETTING: A tertiary-care academic hospital. PARTICIPANTS: Adult patients who underwent open or endovascular rAAA repair; data were stratified into before-protocol implementation (group 1: 2015-2018) and after-protocol implementation (group 2: 2019-2022) groups...
December 17, 2023: Journal of Cardiothoracic and Vascular Anesthesia
https://read.qxmd.com/read/38185965/effect-of-sleep-quality-on-mitochondrial-dna-copy-number-in-eveningness-chronotypes
#30
JOURNAL ARTICLE
Madeeha Maqsood, Shazia Ali, Suhaib Ahmed, Shagufta Feroz
OBJECTIVE: To determine the effect of sleep quality on mitochondrial DNA copy number in eveningness chronotype. STUDY DESIGN: Cross-sectional study. Place and Duration of the Study: Department of Physiology, Islamic International Medical College, in collaboration with Genetic Resource Centre, from August 2022 to May 2023. METHODOLOGY: A total of 80 participants with eveningness chronotype based on the Morningness-Eveningness Questionnaire were recruited...
January 2024: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://read.qxmd.com/read/38183833/trace-metals-and-pesticides-in-water-sediment-and-associated-pollution-load-indicators-of-netravathi-gurupur-estuary-india-implications-on-coastal-pollution
#31
JOURNAL ARTICLE
Ajoy Saha, B K Das, D J Sarkar, S Samanta, M E Vijaykumar, M Feroz Khan, Tania Kayal, Chayna Jana, Vikas Kumar, Pranab Gogoi, Arnab Roy Chowdhury
Various environmental indicators were used to evaluate the water and sediment quality of the Netravathi-Gurupur estuary, India, for trace metals and pesticide pollution. The descended order of studied metal concentrations (μg/L) in the water was Fe (592.71) > Mn (98.35) > Zn (54.69) > Cu (6.64) > Cd (3.24) > Pb (2.38) > Cr (0.82) and in sediment (mg/kg) was Fe (11,396.53) > Mn (100.61) > Cr (75.41) > Zn (20...
January 5, 2024: Marine Pollution Bulletin
https://read.qxmd.com/read/38161524/isotretinoin-use-and-liver-enzymes-changes-a-single-center-study-in-saudi-arabia
#32
JOURNAL ARTICLE
Mahdi Al Dhafiri, Feroze Kaliyadan, Sara Almukhaimar, Fatemah Alsultan, Elham Al Hayim, Roaa Alnaim, Alaa Aldossari
Introduction Isotretinoin is a bioactive retinoic acid variant that is taken orally to treat moderate to severe acne vulgaris. One of the adverse effects of isotretinoin is elevated liver enzymes. This study estimated the prevalence of liver enzyme changes during isotretinoin use among dermatology clinic patients in Al-Ahsa, Kingdom of Saudi Arabia. Methods This study was a retrospective analysis that reviewed the medical data of 97 patients with acne at the King Faisal University Polyclinic who were taking systemic isotretinoin...
December 2023: Curēus
https://read.qxmd.com/read/38143264/peripheral-neutrophil-to-lymphocyte-ratio-nlr-a-cogent-clinical-adjunct-for-ki-67-in-breast-cancer
#33
JOURNAL ARTICLE
Radhika Arora, Feroz Alam, Atia Zaka-Ur-Rab, Veena Maheshwari, Kiran Alam, Mahboob Hasan
BACKGROUND: Clinical utility of Ki-67 immunohistochemistry (IHC) in breast cancer (BC) is mainly limited to decide for the use of chemotherapy and estimate prognosis in patients with either Ki-67 index < 5% or > 30%; however, lacunae still exists pertaining to its analytical validity. Neutrophilia is common in cancer with accompanying lymphocytopenia. Neutrophil to lymphocyte ratio (NLR) captures the intricate balance between pro-tumor neutrophilia and anti-tumor lymphocyte immunity...
December 25, 2023: Journal of the Egyptian National Cancer Institute
https://read.qxmd.com/read/38130863/paraganglioma-induced-reverse-takotsubo-syndrome-treated-with-extracorporeal-membrane-oxygenation-in-a-young-patient-with-a-history-of-malignancy-a-case-report
#34
Steven C Ajluni, Rafey Feroze, Sylvia L Asa, Varun Sundaram
BACKGROUND: Reverse takotsubo-like cardiomyopathy (rTCC) is a rare type of stress-induced cardiomyopathy associated with catecholamine surges. Reverse takotsubo-like cardiomyopathy is characterized by basal and mid-ventricular hypokinesis with apical sparing. Paragangliomas are catecholamine-secreting neuroendocrine tumours outside the adrenal gland that can cause palpitations, hypertension, and rarely cardiomyopathy. In cases of occult paraganglioma, catecholamine-induced rTCC can be rapidly reversed with adequate haemodynamic support...
December 2023: European Heart Journal. Case Reports
https://read.qxmd.com/read/38118338/interaction-mechanism-of-a-cysteine-protease-inhibitor-odanacatib-with-human-serum-albumin-in-vitro-and-bioinformatics-studies
#35
JOURNAL ARTICLE
Nurul Jannah Mohd Asngari, Khairul Azreena Bakar, Shevin Rizal Feroz, Fathilah Abdul Razak, Adyani Azizah Abd Halim
Odanacatib (ODN) is a selective cathepsin K inhibitor that acts as an anti-resorptive agent to treat osteoporosis. ODN is also found effective in reducing the effect of severe periodontitis. The interaction between ODN and human serum albumin (HSA) was investigated using spectroscopic, microscopic, and in silico approaches to characterize their binding. The fluorescence intensity of HSA increased upon the addition of increasing concentrations of ODN accompanied by blueshift in the fluorescence spectrum, which suggested hydrophobic formation around the microenvironment of the fluorophores upon ODN binding...
November 10, 2023: Biophysical Chemistry
https://read.qxmd.com/read/38117250/bcl-2-modulates-ire1%C3%AE-activation-to-attenuate-er-stress-and-pulmonary-fibrosis
#36
JOURNAL ARTICLE
Claude Jourdan Le Saux, Tsung Che Ho, Alexis M Brumwell, Jaymin J Kathiriya, Ying Wei, Jun-Wei B Hughes, Kiana Garakani, Kamran Atabai, Vincent C Auyeung, Feroz R Papa, Harold A Chapman
BCL-2 family members are known to be pro-survival agents in numerous biological settings. Here we provide evidence that in injury and repair processes in lungs, BCL-2 mainly acts to attenuate endoplasmic reticulum (ER) stress and limit extracellular matrix (ECM) accumulation. Days after intratracheal bleomycin mice lose a fraction of their alveolar type II epithelium from terminal ER stress driven by activation of the critical ER sensor and stress effector IRE1-α. This fraction is dramatically increased by BCL-2 inhibition because IRE1-α activation is dependent on its physical association with the BCL-2-pro-apoptotic family member BAX and we found BCL-2 to disrupt this association in vitro...
December 20, 2023: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/38107734/sella-turcica-size-in-women-with-sheehan-syndrome-a-case-control-study
#37
JOURNAL ARTICLE
Bashir Ahmad Laway, Atul Sharma, Naseer Ahmad Choh, Feroze Shaheen, Arshad Iqbal Wani
INTRODUCTION: Sheehan syndrome is a common cause of hypopituitarism in developing countries. Among risk factors, in addition to post-partum haemorrhage, a smaller sellar volume is also believed to predispose to pituitary necrosis. Some earlier studies have reported smaller sellar volume in these patients but involved a small number of patients and lacked matched controls. The main of the present study was to study the sellar volume in a large cohort of patients with Sheehan syndrome and compare it with age- and parity-matched controls...
2023: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38099912/echocardiographic-outcomes-with-transcatheter-edge-to-edge-repair-for-degenerative-mitral-regurgitation-in-prohibitive-surgical-risk-patients
#38
JOURNAL ARTICLE
Leo Marcoff, Konstantinos Koulogiannis, Lilian Aldaia, Anuj Mediratta, Scott M Chadderdon, Moody M Makar, Tobias Friedrich Ruf, Theresa Gößler, Jonathan G Zaroff, Gordon K Leung, Ivy A Ku, Michael Nabauer, Paul A Grayburn, Zuyue Wang, Katie M Hawthorne, Dale E Fowler, Jacob P Dal-Bianco, Mani A Vannan, Carmine Bevilacqua, Massimiliano Meineri, Joerg Ender, Anna Flo Forner, Jyothy J Puthumana, Atizazul Hassan Mansoor, Dustin J Lloyd, Steven J Voskanian, Andrew Ghobrial, Rebecca T Hahn, Feroze Mahmood, Christiane Haeffele, Geraldine Ong, Leonhard Moritz Schneider, Dee Dee Wang, Nishant K Sekaran, Elana Koss, Priti Mehla, Serge Harb, Rhonda Miyasaka, Maria Ivannikova, Terri Stewart-Dehner, Lucas Mitchel, Sasan R Raissi, Daniel Kalbacher, Santanu Biswas, Edwin C Ho, Ythan Goldberg, Robert L Smith, Jörg Hausleiter, D Scott Lim, Linda D Gillam
BACKGROUND: The CLASP IID randomized trial (Edwards PASCAL TrAnScatheter Valve RePair System Pivotal Clinical Trial; NCT03706833) demonstrated the safety and effectiveness of the PASCAL system for mitral transcatheter edge-to-edge repair (M-TEER) in patients at prohibitive surgical risk with significant symptomatic degenerative mitral regurgitation (DMR). OBJECTIVES: This study describes the echocardiographic methods and outcomes from the CLASP IID trial and analyzes baseline variables associated with residual mitral regurgitation (MR) ≤1+...
December 1, 2023: JACC. Cardiovascular Imaging
https://read.qxmd.com/read/38092815/human-ipsc-derived-microglia-carrying-the-lrrk2-g2019s-mutation-show-a-parkinson-s-disease-related-transcriptional-profile-and-function
#39
JOURNAL ARTICLE
Sohvi Ohtonen, Luca Giudice, Henna Jäntti, Mohammad Feroze Fazaludeen, Anastasia Shakirzyanova, Mireia Gómez-Budia, Nelli-Noora Välimäki, Jonna Niskanen, Nea Korvenlaita, Ilkka Fagerlund, Jari Koistinaho, Mahmood Amiry-Moghaddam, Ekaterina Savchenko, Laurent Roybon, Šárka Lehtonen, Paula Korhonen, Tarja Malm
LRRK2-G2019S is one of the most common Parkinson's disease (PD)-associated mutations and has been shown to alter microglial functionality. However, the impact of LRRK2-G2019S on transcriptional profile of human induced pluripotent stem cell-derived microglia-like cells (iMGLs) and how it corresponds to microglia in idiopathic PD brain is not known. Here we demonstrate that LRRK2-G2019S carrying iMGL recapitulate aspects of the transcriptional signature of human idiopathic PD midbrain microglia. LRRK2-G2019S induced subtle and donor-dependent alterations in iMGL mitochondrial respiration, phagocytosis and cytokine secretion...
December 13, 2023: Scientific Reports
https://read.qxmd.com/read/38086736/synthesis-of-mixed-phosphorotrithioates-via-thiol-coupling-with-bis-diisopropylamino-chlorophosphine-and-sulphenyl-chloride
#40
JOURNAL ARTICLE
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
In this study, we report a novel and efficient one-pot synthesis of mixed phosphorotrithioates under mild conditions at ambient temperature, obviating the requirement for supplementary additives. The method's versatility stems from its utilization of diverse thiols as nucleophilic reactants, 1-chloro- N , N , N ', N '-tetraisopropylphosphanediamine [bis(diisopropylamino)chlorophosphine] as the phosphorus precursor, and various sulphenyl chlorides as sources of electrophilic sulfur. Notably, our investigation extends beyond mixed phosphorotrithioates to encompass the synthesis of phosphoroselenodithioates, underscoring the broad applicability of this synthetic protocol...
December 12, 2023: Organic & Biomolecular Chemistry
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