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Benxu Cheng, Pinki Anand, Anxiu Kuang, Feroz Akhtar, Virginia L Scofield
Ubiquitin proteasome system (UPS) dysfunction has been implicated in the development of many neuronal disorders, including Parkinson's disease (PD). Previous studies focused on individual neuroprotective agents and their respective abilities to prevent neurotoxicity following a variety of toxic insults. However, the effects of the antioxidant N-acetylcysteine (NAC) on proteasome impairment-induced apoptosis have not been well characterized in human neuronal cells. The aim of this study was to determine whether cotreatment of NAC and insulin-like growth factor-1 (IGF-1) efficiently protected against proteasome inhibitor-induced cytotoxicity in SH-SY5Y cells...
2016: Parkinson's Disease
Hema Negi, Aparna Shukla, Feroz Khan, Rakesh Pandey
Remarkably the c-Jun-NH2-terminal kinase (JNK) pathway is all evolutionarily conserved across species. In view of the hypothesis that increased stress resistance subdue aging, we investigated the role of ursolic acid (3β-Hydroxy-urs-12-en-28-oic acid; UA) in the pioneering aging model Caenorhabditis elegans with an increase in mean and maximum lifespan by up to 30%. Our genetic study unravelled the underlying pathway where JNK-1 is acting independently of insulin-IGF-1 signalling (IIS) pathway to modulate longevity...
October 20, 2016: Biochemical and Biophysical Research Communications
Arash Khamooshian, Feroze Mahmood
No abstract text is available yet for this article.
August 10, 2016: Journal of Cardiothoracic and Vascular Anesthesia
Gregory M Weiner, Rafey Feroze, David M Panczykowski, Amin Aghaebrahim, William Ares, Nitin Agarwal, John Enis, Xiao Zhu, Andrew F Ducruet
INTRODUCTION: Tandem occlusion resulting in acute ischemic stroke (AIS) is associated with high morbidity and mortality and a poor response to thrombolytic therapy. The use of endovascular strategies for tandem stroke cases results in an improved outcome for this subgroup of patients. We present two cases with a pattern of tandem occlusion consisting of proximal obstruction at the origin of the common carotid artery (CCA) with concomitant intracranial occlusion treated by endovascular techniques...
October 14, 2016: World Neurosurgery
Karalikkattil T Ashique, Feroze Kaliyadan
No abstract text is available yet for this article.
November 2016: Journal of the American Academy of Dermatology
Asifa Wali, Masood-Ul Hassan Balkhi, Rafia Maqbool, Mohammed Maqbool Darzi, Feroz Ahmad Shah, Farooz Ahmad Bhat, Bilal Ahmad Bhat
The present study was undertaken to determine the incidence of helminth parasites in fishes with special reference to water quality parameters in Dal Lake and River Jhelum and correlate the observations. Water, fish, and parasite samples were collected during different seasons from various sites and processed. Three fish species, namely, Schizothorax niger Heckel 1838, Schizothorax esocinus Heckel 1838, and Schizothorax curvifrons Heckel 1838, were recovered from these water bodies. The physicochemical parameters temperature, dissolved oxygen, pH, and free carbon dioxide showed variation vis-à-vis the season and location of the stations in water bodies...
2016: Journal of Parasitology Research
Omar J Shah, Sadaf A Bangri, Manmohan Singh, Reyaz A Lattoo, Mohammad Y Bhat, Feroze A Khan
BACKGROUND: Fast track strategy in the management of patients undergoing intra-abdominal surgery of various types has emerged as a landmark approach to reduce surgical stress and accelerate recovery. This study was to evaluate the effect of fast track strategy on patients subjected to pancreaticoduodenectomy (PD) from an individual unit during transit from low to a high volume center. METHODS: A total of 142 PD patients who had been subjected to fast track strategy between June 2008 and September 2012 were compared with 46 patients who had received conventional surgery between January 2006 and May 2008...
October 2016: Hepatobiliary & Pancreatic Diseases International: HBPD INT
Shumyla Jabeen, Irfan Robbani, Naseer A Choh, Obaid Ashraf, Feroze Shaheen, Tariq Gojwari, Sabeeha Gul
OBJECTIVE: To characterize biliary abnormalities seen in portal cavernoma cholangiopathy (PCC) on Magnetic Resonance Cholangiopancreaticography(MRCP) and elucidate certain salient features of the disease by collaborating our findings with those of previous studies. METHODS: We prospectively enrolled 52 patients with portal cavernoma secondary to idiopathic Extrahepatic portal vein obstruction(EHPVO) who underwent a standard MRCP protocol. Images were analysed for abnormalities involving the entire biliary tree...
October 12, 2016: British Journal of Radiology
Feroze Kaliyadan, Joel Pulickal Kuruvilla
No abstract text is available yet for this article.
September 2016: Indian Dermatology Online Journal
Feroze Kaliyadan
No abstract text is available yet for this article.
September 2016: Indian Dermatology Online Journal
Kimberly Naden Hollander, Mario Montealegre-Gallegos, Feroze Mahmood
In recent years, the use of transcatheter aortic valve replacement (TAVR) has extended beyond the treatment of native aortic valve stenosis in patients with high surgical risk. TAVR is increasingly being performed for bioprosthetic aortic valve failure, i.e., the valve-in-valve (VIV) procedure. Establishing the success of a VIV procedure can be challenging in these cases. Furthermore, the limited availability of prostheses sizes further complicates the management of these patients. We present an unusual case of a repeat TAVR in a patient who previously had a VIV procedure in an aortic homograft...
October 2016: Annals of Cardiac Anaesthesia
Ziyad O Knio, Mario Montealegre-Gallegos, Lu Yeh, Bilal Chaudary, Jelliffe Jeganathan, Robina Matyal, Kamal R Khabbaz, David C Liu, Venkatachalam Senthilnathan, Feroze Mahmood
BACKGROUND: Traditional two-dimensional (2D) echocardiographic evaluation of tricuspid annulus (TA) dilation is based on single-frame measurements of the septolateral (S-L) dimension. This may not represent either the axis or the extent of dynamism through the entire cardiac cycle. In this study, we used real-time 3D transesophageal echocardiography (TEE) to analyze geometric changes in multiple axes of the TA throughout the cardiac cycle in patients without right ventricular abnormalities...
October 2016: Annals of Cardiac Anaesthesia
Jelliffe Jeganathan, Feroze Mahmood
No abstract text is available yet for this article.
July 7, 2016: Journal of Cardiothoracic and Vascular Anesthesia
Lu Yeh, Mario Montealegre-Gallegos, Feroze Mahmood, Philip E Hess, Marc Shnider, John D Mitchell, Stephanie B Jones, Azad Mashari, Vanessa Wong, Robina Matyal
OBJECTIVES: Understanding of the workflow of perioperative ultrasound (US) examination is an integral component of proficiency. Workflow consists of the practical steps prior to executing an US examination (eg, equipment operation). Whereas other proficiency components (ie, cognitive knowledge and manual dexterity) can be tested, workflow understanding is difficult to define and assess due to its contextual and institution-specific nature. The objective was to define the workflow components of specific perioperative US applications using an iterative process to reach a consensus opinion...
July 9, 2016: Journal of Cardiothoracic and Vascular Anesthesia
Nadeem Ullah Khan, Uzma Rahim Khan, Asher Feroze, Sajjad Ali Khan, Najia Ali, Kiran Ejaz, Afshan Rahim Khan, Shahnila Nooruddin, Jabeen Fayyaz
OBJECTIVE: To determine the trends of acute poisoning in terms of frequency, nature of poisoning agent, clinical presentation and its outcome. METHODS: The retrospective study was conducted at the Aga Khan University Hospital, Karachi, and comprised data of patients who presented with poisoning between January 1989 and December 2010.The patients were randomly selected , and demographic, chemical information, clinical feature, treatment and outcome were analysed using SPSS 16...
October 2016: JPMA. the Journal of the Pakistan Medical Association
Dheeaa Al Deen Atallah Aljuboury, Puganeshwary Palaniandy, Hamidi Bin Abdul Aziz, Shaik Feroz, Salem S Abu Amr
The aim of this study is to investigate the performance of combined solar photo-catalyst of titanium oxide/zinc oxide (TiO2/ZnO) with aeration processes to treat petroleum wastewater. Central composite design with response surface methodology was used to evaluate the relationships between operating variables for TiO2 dosage, ZnO dosage, air flow, pH, and reaction time to identify the optimum operating conditions. Quadratic models for chemical oxygen demand (COD) and total organic carbon (TOC) removals prove to be significant with low probabilities (<0...
September 2016: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Sarita Singh, Ateeque Ahmad, Dushyant Singh Raghuvanshi, Mohammad Hasanain, Karishma Agarwal, Vijaya Dubey, Kaniz Fatima, Sarfaraz Alam, Jayanta Sarkar, Suaib Luqman, Feroz Khan, Sudeep Tandon, Atul Gupta
Different alkyl amide (15a-l) and alkyl amine (16a-e) derivatives of 7,8-dimethoxy-3-hydroxy-2-(4-methoxyphenyl)benzopyran-4-one were synthesized and evaluated for their anticancer activity against five different cancer cell lines using SRB assay. Compounds 15e, 15i, 15j and 16a-e showed significant anticancer activity within the range of IC50 2.58-34.86μM. The most promising molecule, 16c, was further analyzed for its effect on cell cycle and apoptosis of estrogen receptor positive cancer cells (MCF-7 cells) which showed that 16c triggered apoptosis in MCF-7 cells and arrested cells population at sub-G0 (apoptotic) and G2M phase...
September 15, 2016: Bioorganic & Medicinal Chemistry Letters
Farah Shahnaz Feroz, Gregor Leicht, Saskia Steinmann, Christina Andreou, Christoph Mulert
Growing evidence from neuroimaging studies suggest that emotional and cognitive processes are interrelated. Anatomical key structures in this context are the dorsal and rostral-ventral anterior cingulate cortex (dACC and rvACC). However, up to now, the time course of activations within these regions during emotion-cognition interactions has not been disentangled. In the present study, we used event-related potentials (ERP) and standardized low-resolution electromagnetic tomography (sLORETA) region of interest (ROI) source localization analyses to explore the time course of neural activations within the dACC and rvACC using a modified emotional Stroop paradigm...
September 22, 2016: Brain Topography
Shagufta Yousuf, Abida Ahmad, Shazia Qadir, Sabia Gul, Showkat Hussain Tali, Feroz Shaheen, Shareefa Akhtar, Rayees Dar
OBJECTIVE: To find out whether placental laterality and abnormal uterine artery waveform and resistance index, as determined by antenatal ultrasonography and Doppler, can be used as a predictor for the development of preeclampsia. METHODS: This prospective observational cohort study was conducted from August 2013 to October 2014. Two hundred and one (201) normotensive, primigravida women with singleton pregnancies attending the antenatal clinics without any high-risk factor for development of hypertension were subjected to ultrasonography at 18-22 weeks of gestation to determine the placenta location...
October 2016: Journal of Obstetrics and Gynaecology of India
Wei Qi Lee, Ida Syazwani M Affandi, Shevin R Feroz, Saharuddin B Mohamad, Saad Tayyab
Interaction of pendimethalin (PM) herbicide with the major transporter in human circulation, human serum albumin (HSA), was studied using fluorescence, circular dichroism (CD), and molecular modeling methods. The attenuation of the fluorescence intensity of HSA in the presence of PM revealed formation of the PM-HSA complex. Analysis of the fluorescence quenching data showed moderately strong binding affinity between PM and HSA. Both hydrophobic interactions and hydrogen bonding were suggested to stabilize the PM-HSA complex, based on thermodynamic data...
September 16, 2016: Journal of Biochemical and Molecular Toxicology
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