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https://www.readbyqxmd.com/read/29467933/determinants-of-variability-of-five-programmed-death-ligand-1-immunohistochemistry-assays-in-non-small-cell-lung-cancer-samples
#1
Ross A Soo, Joey Sze Yun Lim, Bernadette Reyna Asuncion, Zul Fazreen, Maria Cynthia Herrera, Mohd Feroz Mohd Omar, Nguyen Hoang Diem Phuong, Ju Ee Seet, Benhur Amanuel, Barry Iacopetta, David Byrne, Shona Hendry, Stephen Fox, Richie Soong
Programmed death ligand-1 (PD-L1) expression as determined by immunohistochemistry (IHC) is potentially predictive of clinical outcome. The aim of this study was to assess the concordance of reported PD-L1 IHC assays and investigate factors influencing variability. Consecutive sections from 20 non-small cell lung cancers (NSCLCs) comprising resection, core biopsy, cytology and pleural fluid samples underwent IHC with 5 different antibody/autostainer combinations: 22C3/Link48, 28-8/BOND-MAX, E1L3N/BOND-MAX, SP142/BenchMark and SP263/BenchMark...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29459129/synthesis-and-biological-evaluation-of-imidazo-2-1-b-thiazole-benzimidazole-conjugates-as-microtubule-targeting-agents
#2
Mirza Feroz Baig, V Lakshma Nayak, Prasad Budaganaboyina, Kishore Mullagiri, Satish Sunkari, Jitendra Gour, Ahmed Kamal
A series of imidazo[2,1-b]thiazole-benzimidazole conjugates were synthesized and evaluated for their antiproliferative activity against four human cancer cell lines i.e.; HeLa (cervical), A549 (lung), MCF-7 (breast) and DU-145 (prostate) along with normal HEK-293 cell line. Amongst them, conjugate 6d displayed significant cytotoxicity against human lung cancer cell line, A549 with IC50 value 1.08 µM. Further, cell cycle analysis revealed that this compound arrested the cell cycle at G2/M phase in A549 cells...
February 12, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29452879/augmented-reality-and-ultrasound-education-initial-experience
#3
REVIEW
Faraz Mahmood, Eitezaz Mahmood, Robert Gregory Dorfman, John Mitchell, Feroze-Udin Mahmood, Stephanie B Jones, Robina Matyal
No abstract text is available yet for this article.
December 6, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29415675/teaching-children-road-safety-through-storybooks-an-approach-to-child-health-literacy-in-pakistan
#4
Haris Ahmad, Rubaba Naeem, Asher Feroze, Nukhba Zia, Amarah Shakoor, Uzma Rahim Khan, Asad Iqbal Mian
BACKGROUND: Road traffic injuries (RTIs) commonly affect the younger population in low- and-middle-income countries. School children may be educated about road safety using storybooks with colorful pictures, which tends to increase the child's interest in the text. Therefore, this study assessed the use of bilingual pictorial storybooks to improve RTI prevention knowledge among school children. METHODS: This pretest-posttest study was conducted in eight public and nine private schools of Karachi, Pakistan, between February to May 2015...
February 7, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29410232/tip-to-protect-the-tip-an-inexpensive-alternative-to-protect-damage-to-fine-instruments-during-sterilization
#5
K T Ashique, Feroze Kaliyadan
No abstract text is available yet for this article.
February 1, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29381519/summative-objective-structured-clinical-examination-assessment-at-the-end-of-anesthesia-residency-for-perioperative-ultrasound
#6
John D Mitchell, Rabia Amir, Mario Montealegre-Gallegos, Feroze Mahmood, Marc Shnider, Azad Mashari, Lu Yeh, Ruma Bose, Vanessa Wong, Philip Hess, Yannis Amador, Jelliffe Jeganathan, Stephanie B Jones, Robina Matyal
While standardized examinations and data from simulators and phantom models can assess knowledge and manual skills for ultrasound, an Objective Structured Clinical Examination (OSCE) could assess workflow understanding. We recruited 8 experts to develop an OSCE to assess workflow understanding in perioperative ultrasound. The experts used a binary grading system to score 19 graduating anesthesia residents at 6 stations. Overall average performance was 86.2%, and 3 stations had an acceptable internal reliability (Kuder-Richardson formula 20 coefficient >0...
January 29, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29371722/physiotherapy-and-pharmacy-students-perception-of-educational-environment-in-a-medical-university-from-pakistan
#7
Aamir Raoof Memon, Bahadur Ali, Mubin Mustafa Kiyani, Imran Ahmed, Attiq-Ur-Rehman Memon, Jam Feroz
OBJECTIVE: To assess and compare the perceptions of the educational environment between physiotherapy and pharmacy students in a public-sector medical university. METHODS: This cross-sectional study was conducted at the Peoples University of Medical and Health Sciences for Women, Nawabshah, Pakistan, and comprised undergraduate physiotherapy and pharmacy students. The Dundee Ready Educational Environment Measure questionnaire was used to assess the perceptions of students about their educational environment...
January 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/29366135/lysosomal-oxidation-of-ldl-and-its-implications-for-atherosclerosis
#8
Feroz Ahmad, David Leake
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29356530/probing-the-ionic-atmosphere-and-hydration-of-the-c-myc-i-motif
#9
Lutan Liu, Byul G Kim, Ujala Feroze, Robert B Macgregor, Tigran V Chalikian
G-quadruplexes and i-motifs are non-canonical secondary structures of DNA that appear to play a number of regulatory roles in the genome with clear connection to disease. Characterization of the forces stabilizing these structures is necessary for developing an ability to induce of G-quadruplex and/or i-motif structures at selected genomic loci in a controlled manner. We report here the results of pH-dependent acoustic and densimetric measurements and UV melting experiments at high pressures to scrutinize changes in hydration and ionic atmosphere accompanying i-motif formation by the C-rich DNA sequence from the promoter region of the human c-MYC oncogene [5'-d(TTA¬CCC¬ACCCTACCCACCCTCA)] (ODN)...
January 22, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29346071/identification-of-potential-inhibitors-against-nuclear-dam1-complex-subunit-ask1-of-candida-albicans-using-virtual-screening-and-md-simulations
#10
Himanshu Tripathi, Feroz Khan
Identification of hit compounds against specific target form the starting point for a drug discovery program. A consistent decline of new chemical entities (NCEs) in recent years prompted a challenge to explore newer approaches to discover potential hit compounds that in turn can be converted into leads, and ultimately drug with desired therapeutic efficacy. The vast amount of omics and activity data available in public databases offers an opportunity to identify novel targets and their potential inhibitors...
January 1, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29340936/application-of-color-transformation-techniques-in-pediatric-spinal-cord-mr-images-typically-developing-and-spinal-cord-injury-population
#11
Mahdi Alizadeh, Pallav Shah, Chris J Conklin, Devon M Middleton, Sona Saksena, Adam E Flanders, Laura Krisa, M J Mulcahey, Scott H Faro, Feroze B Mohamed
The purpose of this study was to evaluate an improved and reliable visualization method for pediatric spinal cord MR images in healthy subjects and patients with spinal cord injury (SCI). A total of 15 pediatric volunteers (10 healthy subjects and 5 subjects with cervical SCI) with a mean age of 11.41 years (range 8-16 years) were recruited and scanned using a 3.0T Siemens Verio MR scanner. T2-weighted axial images were acquired covering entire cervical spinal cord level C1 to C7. These gray-scale images were then converted to color images by using five different techniques including hue-saturation-value (HSV), rainbow, red-green-blue (RGB), and two enhanced RGB techniques using automated contrast stretching and intensity inhomogeneity correction...
January 16, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29336402/mechanical-discordance-between-left-atrium-and-left-atrial-appendage
#12
Arash Khamooshian, Jelliffe Jeganthan, Yannis Amador, Roger J Laham, Feroze Mahmood, Robina Matyal
During standard transesophageal echocardiographic examinations in sinus rhythm (SR) patients, the left atrial appendage (LAA) is not routinely assessed with Doppler. Despite having a SR, it is still possible to have irregular activity in the LAA. This situation is even more important for SR patients where assessment of the left atrium is often foregone. We describe a case where we encountered this situation and briefly review how to assess the left atrium and its appendage in such a case scenario.
January 2018: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/29303199/iodine-mediated-oxidative-cross-coupling-of-unprotected-anilines-and-heteroarylation-of-benzothiazoles-with-2-methylquinoline
#13
Abdul Rahim, Siddiq Pasha Shaik, Mirza Feroz Baig, Abdullah Alarifi, Ahmed Kamal
Iodine-promoted oxidative C-H/C-H cross-coupling of unprotected anilines and 2-methylquinoline to furnish C4-carbonylated aniline (4-aminophenyl)(quinoline-2-yl) methanones in moderate to good yields has been demonstrated. This work provides the first site-selective approach for the synthesis of free amino groups containing methanones including unprecedented C-H functionalization rather than the N-H functionalization of unprotected anilines via the Kornblum oxidation of 2-methylquinoline. Furthermore, we noticed that the incorporation of KOH under standard conditions provides 2-heteroarylbenzothiazoles from benzothiazoles and 2-methylquinoline in good to excellent yields...
January 5, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29299135/acquired-resistance-to-pi3k-mtor-inhibition-is-associated-with-mitochondrial-dna-mutation-and-glycolysis
#14
King Xin Koh, Gim Hwa Tan, Sarah Hong Hui Low, Mohd Feroz Mohd Omar, Min Ji Han, Barry Iacopetta, Ross Soo, Mounia Beloueche-Babari, Bhaskar Bhattacharya, Richie Soong
Acquired resistance (AQR) to drug treatment occurs frequently in cancer patients and remains an impediment to successful therapy. The aim of this study was to gain insight into how AQR arises following the application of PI3K/mTOR inhibitors. H1975 lung cancer cells with EGFR T790M mutations that confer resistance to EGFR inhibitors underwent prolonged treatment with the PI3K/mTOR inhibitor, BEZ235. Monoclonal cells with stable and increased resistance to BEZ235 were obtained after 8 months treatment. These AQR clones showed class-specific resistance to PI3K/mTOR inhibitors, reduced G1 cell cycle arrest and impedance of migration following PI3K/mTOR inhibition, reduced PTEN expression and increased Akt and S6RP phosphorylation...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29298995/nuclear-receptor-gene-polymorphisms-and-warfarin-dose-requirements-in-the-quebec-warfarin-cohort
#15
Payman Shahabi, Félix Lamothe, Stéphanie Dumas, Étienne Rouleau-Mailloux, Yassamin Feroz Zada, Sylvie Provost, Geraldine Asselin, Ian Mongrain, Diane Valois, Marie-Josée Gaulin Marion, Louis-Philippe Lemieux Perreault, Sylvie Perreault, Marie-Pierre Dubé
Warfarin is primarily metabolized by cytochrome 2C9, encoded by gene CYP2C9. Here, we investigated whether variants in nuclear receptor genes which regulate the expression of CYP2C9 are associated with warfarin response. We used data from 906 warfarin users from the Quebec Warfarin Cohort (QWC) and tested the association of warfarin dose requirement at 3 months following the initiation of therapy in nine nuclear receptor genes: NR1I3, NR1I2, NR3C1, ESR1, GATA4, RXRA, VDR, CEBPA, and HNF4A. Three correlated SNPs in the VDR gene (rs4760658, rs11168292, and rs11168293) were associated with dose requirements of warfarin (P = 2...
January 3, 2018: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/29277300/innovations-in-preoperative-planning-insights-into-another-dimension-using-3d-printing-for-cardiac-disease
#16
REVIEW
Kanwal M Farooqi, Feroze Mahmood
Two-dimensional visualization of complex congenital heart disease has limitations in that there is variation in the interpretation by different individuals. Three-dimensional printing technology has been in use for decades but is currently becoming more commonly used in the medical field. Congenital heart disease serves as an ideal pathology to employ this technology because of the variation of anatomy between patients. In this review, the authors aim to discuss basics of applicability of three-dimensional printing, the process involved in creating a model, as well as challenges with establishing utility and quality...
November 23, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29260274/spontaneous-regression-of-an-idiopathic-arteriovenous-fistula-of-the-right-vertebral-artery
#17
Omar Choudhri, Mircea C Dobre, Abdullah Feroze, Nikhil Sharma, Huy M Do
A previously healthy 53-year-old male presented with a 2-month history of pulsatile tinnitus, worsening headaches, and neck pain. Given the clinical symptoms, a workup was initiated to assess for a vascular etiology such as a dural arteriovenous fistula.
December 19, 2017: Neuroradiology
https://www.readbyqxmd.com/read/29225426/incidence-and-predictors-of-total-knee-arthroplasty-following-knee-arthroscopy
#18
Tristan Camus, Jiho Han, Feroz Osmani, Norman Scott, William J Long
Objective: The purpose of this study was to determine the effectiveness of knee arthroscopy (KA) in patients with symptomatic meniscal tears or mechanical symptoms and OA, by using conversion to TKA as a final outcome measure. Methods: Retrospective review of all patients with OA who underwent KA in our practice. Results: 1215 KAs were reviewed; 3.9% underwent conversion to TKA at an average of 3.2 years. Conclusion: KA plays a role in delaying TKA in knees with meniscal tears and mechanical symptoms with concurrent OA...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29220051/improving-extraction-and-post-purification-concentration-of-membrane-proteins
#19
Hasin Feroz, HyeYoung Kwon, Jing Peng, Hyeonji Oh, Bryan Ferlez, Carol S Baker, John H Golbeck, Guillermo C Bazan, Andrew L Zydney, Manish Kumar
Membrane proteins (MPs), despite being critically important drug targets for the pharmaceutical industry, are difficult to study due to challenges in obtaining high yields of functional protein. Most current extraction efforts use specialized non-ionic detergents to solubilize and stabilize MPs, with MPs being concentrated by ultrafiltration (UF). However, many detergents are retained during the UF step, which can destabilize MPs and/or interfere with their characterization. Here, we studied the influence of detergent selection on the extraction and UF-based concentration of biomedically-relevant MPs, the light-driven sodium and chloride transporters, KR2 and halorhodopsin (pHR) which are also model proteins for more complex mammalian rhodopsins...
December 8, 2017: Analyst
https://www.readbyqxmd.com/read/29204499/variance-in-predicted-cup-size-by-2-dimensional-vs-3-dimensional-computerized-tomography-based-templating-in-primary-total-hip%C3%A2-arthroplasty
#20
Feroz A Osmani, Savyasachi Thakkar, Austin Ramme, Ameer Elbuluk, Paul Wojack, Jonathan M Vigdorchik
Background: Preoperative total hip arthroplasty templating can be performed with radiographs using acetate prints, digital viewing software, or with computed tomography (CT) images. Our hypothesis is that 3D templating is more precise and accurate with cup size prediction as compared to 2D templating with acetate prints and digital templating software. Methods: Data collected from 45 patients undergoing robotic-assisted total hip arthroplasty compared cup sizes templated on acetate prints and OrthoView software to MAKOplasty software that uses CT scan...
December 2017: Arthroplasty Today
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