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https://www.readbyqxmd.com/read/28094172/interval-changes-in-myocardial-performance-index-predict-outcome-in-severe-sepsis
#1
Junaid Nizamuddin, Feroze Mahmood, Avery Tung, Ariel Mueller, Samuel M Brown, Shahzad Shaefi, Michael O'Connor, Daniel Talmor, Sajid Shahul
OBJECTIVES: Septic cardiomyopathy is a well-described consequence of septic shock and is associated with increased sepsis-related mortality. The myocardial performance index (MPI), a parameter derived from echocardiographic tissue Doppler measurements, allows for a more sensitive assessment of global cardiac function than do traditional metrics for cardiac function. The authors hypothesized that changes in left ventricular MPI in patients with severe sepsis would be associated with a higher 90-day mortality...
November 2, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28073915/ube2e1-ubch6-is-a-critical-in-vivo-e2-for-the-prc1-catalyzed-ubiquitination-of-h2a-at-k119
#2
Keith Wheaton, Feroz Sarkari, Beena Stanly Johns, Hossein Davarinejad, Olga Egorova, Lilia Kaustov, Brian Raught, Vivian Saridakis, Yi Sheng
UbE2E1/UbcH6 is an E2 ubiquitin conjugating enzyme that is regulated by USP7. We identified UbE2E1 as a novel component of Polycomb Repressive Complex 1 (PRC1), the E3 ligase complex responsible for histone H2A ubiquitination and gene silencing. We demonstrate that UbE2E1 is critical for the mono-ubiquitination of H2A at residue K119 (uH2AK119) through its association with the PRC1 complex. UbE2E1 interacts with PRC1 subunits including Ring1A and Ring1B. Overexpression of UbE2E1 results in increased levels of uH2AK119 whereas overexpression of catalytically inactive UbE2E1C131A or UbE2E1 knockdown results in decreased levels of uH2AK119...
January 10, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28068903/comparative-transcriptome-analysis-reveals-candidate-genes-for-the-biosynthesis-of-natural-insecticide-in-tanacetum-cinerariifolium
#3
Sana Khan, Swati Upadhyay, Feroz Khan, Sudeep Tandon, Rakesh Kumar Shukla, Sumit Ghosh, Vikrant Gupta, Suchitra Banerjee, Laiq Ur Rahman
BACKGROUND: Pyrethrins are monoterpenoids and consist of either a chrysanthemic acid or pyrethric acid with a rethrolone moiety. Natural pyrethrins are safe and eco-friendly while possessing strong insecticidal properties. Despite such advantages of commercial value coming with the eco-friendly tag, most enzymes/genes involved in the pyrethrin biosynthesis pathway remain unidentified and uncharacterized. Since the flowers of Tanacetum cinerariifolium are rich in major pyrethrins, next generation transcriptome sequencing was undertaken to compare the flowers and the leaves of the plant de novo to identify differentially expressed transcripts and ascertain which among them might be involved in and responsible for the differential accumulation of pyrethrins in T...
January 9, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28041808/three-dimensional-examination-of-the-mitral-valve-in-patients-with-arrhythmias-and-motion-artifacts
#4
REVIEW
Arash Khamooshian, Yannis Amador, Jelliffe Jeganathan, Andrew Maslow, Feroze Mahmood
No abstract text is available yet for this article.
October 26, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28007759/magnetic-resonance-perfusion-image-features-uncover-an-angiogenic-subgroup-of-glioblastoma-patients-with-poor-survival-and-better-response-to-antiangiogenic-treatment
#5
Tiffany T Liu, Achal S Achrol, Lex A Mitchell, Scott A Rodriguez, Abdullah Feroze, Christine Kim, Navjot Chaudhary, Olivier Gevaert, Josh M Stuart, Griffith R Harsh, Steven D Chang, Daniel L Rubin
BACKGROUND: In previous clinical trials, antiangiogenic therapies such as bevacizumab did not show efficacy in patients with newly diagnosed glioblastoma (GBM). This may be a result of the heterogeneity of GBM, which has a variety of imaging-based phenotypes and gene expression patterns. In this study, we sought to identify a phenotypic subtype of GBM patients who have distinct tumor-image features and molecular activities and who may benefit from antiangiogenic therapies. METHODS: Quantitative image features characterizing subregions of tumors and the whole tumor were extracted from preoperative and pretherapy perfusion magnetic resonance (MR) images of 117 GBM patients in 2 independent cohorts...
December 22, 2016: Neuro-oncology
https://www.readbyqxmd.com/read/28004909/a-rationally-designed-general-strategy-for-membrane-orientation-of-photoinduced-electron-transfer-based-voltage-sensitive-dyes
#6
Rishikesh U Kulkarni, Hang Yin, Narges Pourmandi, Feroz James, Maroof M Adil, David V Schaffer, Yi Wang, Evan W Miller
Voltage imaging with fluorescent dyes offers promise for interrogating the complex roles of membrane potential in coordinating the activity of neurons in the brain. Yet, low sensitivity often limits the broad applicability of optical voltage indicators. In this paper, we use molecular dynamics (MD) simulations to guide the design of new, ultrasensitive fluorescent voltage indicators that use photoinduced electron transfer (PeT) as a voltage-sensing switch. MD simulations predict an approximately 16% increase in voltage sensitivity resulting purely from improved alignment of dye with the membrane...
December 22, 2016: ACS Chemical Biology
https://www.readbyqxmd.com/read/28003631/bacterial-and-fungal-counts-of-dried-and-semi-dried-foods-collected-from-dhaka-bangladesh-and-their-reduction-methods
#7
Farahnaaz Feroz, Hiromi Shimizu, Terumi Nishioka, Miho Mori, Yoshikazu Sakagami
 Food is a basic necessity for human survival, but it is still the vehicle for the transmission of food borne disease. Various studies have examined the roles of spices, herbs, nuts, and semi-dried fruits, making the need for safe and convenient methods of decontamination a necessity. The current study determined the bacterial and fungal loads of 26 spices and herbs, 5 nuts, 10 semi-dried fruits and 5 other foods. Spices, herbs and semi-dried foods demonstrated the highest bacterial and fungal loads with the majority showing over 10(4) CFU/mL...
2016: Biocontrol Science
https://www.readbyqxmd.com/read/27994747/discovery-and-optimization-of-a-novel-triazole-series-of-gpr142-agonists-for-the-treatment-of-type-2-diabetes
#8
Liangqin Guo, Dann L Parker, Yi Zang, Ramzi F Sweis, Weiguo Liu, Edward C Sherer, Nicole Buist, Jenna Terebetski, Terri Kelly, Randal Bugianesi, Birgit T Priest, Karen H Dingley, Xiaofang Li, Stan Mitelman, Gino Salituro, Maria E Trujillo, Michele Pachanski, Melissa Kirkland, Mary Ann Powles, George J Eiermann, Yue Feng, Jin Shang, Andrew D Howard, Feroze Ujjainwalla, Christopher J Sinz, John S Debenham, Scott D Edmondson, Ravi P Nargund, William K Hagmann, Derun Li
GPR142 has been identified as a potential glucose-stimulated insulin secretion (GSIS) target for the treatment of type 2 diabetes mellitus (T2DM). A class of triazole GPR142 agonists was discovered through a high throughput screen. The lead compound 4 suffered from poor metabolic stability and poor solubility. Lead optimization strategies to improve potency, efficacy, metabolic stability, and solubility are described. This optimization led to compound 20e, which showed significant reduction of glucose excursion in wild-type but not in GPR142 deficient mice in an oral glucose tolerance test (oGTT) study...
December 8, 2016: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27990409/dermoscopic-pattern-in-a-case-of-suction-purpura-over-the-face
#9
Feroze Kaliyadan
No abstract text is available yet for this article.
November 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27984342/strategies-to-prevent-periprosthetic-joint-infection-after-total-knee-arthroplasty-and-lessen-the-risk-of-readmission-for-the-patient
#10
Richard Iorio, Feroz Osmani
There is yet to be a standardized total knee arthroplasty (TKA) surgical protocol that has been studied to a sufficient degree to offer evidence-based practices regarding infection and readmission prevention. Although high-level evidence is often sought to provide guidance concerning protocol- and process-level decisions, the literature is often confusing and nondefinitive in its conclusions and recommendations regarding periprosthetic joint infection and readmission prevention. Areas of study that require further investigation include the following: the role of patient optimization and preoperative mitigation of risk; perioperative antibiotics; operating room environment; blood management; operative techniques, implants, and infection prevention measures; wound care management; and post acute care...
December 13, 2016: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/27974356/making-three-dimensional-echocardiography-more-tangible-a-workflow-for-three-dimensional-printing-with-echocardiographic-data
#11
REVIEW
Azad Mashari, Mario Montealegre-Gallegos, Ziyad Knio, Lu Yeh, Jelliffe Jeganathan, Robina Matyal, Kamal R Khabbaz, Feroze Mahmood
Three-dimensional (3D) printing is a rapidly evolving technology with several potential applications in the diagnosis and management of cardiac disease. Recently, 3D printing (i.e. rapid prototyping) derived from 3D transesophageal echocardiography (TEE) has become possible. Due to the multiple steps involved and the specific equipment required for each step, it might be difficult to start implementing echocardiography-derived 3D printing in a clinical setting. In this review, we provide an overview of this process, including its logistics and organization of tools and materials, 3D TEE image acquisition strategies, data export, format conversion, segmentation, and printing...
December 2016: Echo Research and Practice
https://www.readbyqxmd.com/read/27965482/comparative-evaluation-of-antibacterial-effect-of-dental-luting-cements-on-streptococcus-mutans-and-lactobacillus-acidophilus-an-in-vitro-study
#12
Sma Feroz, A Bhoyar, S Khan
INTRODUCTION: This study aimed at evaluating and comparing the antibacterial activity of six types of dental luting cements on Streptococcus mutans and Lactobacillus acidophilus using the agar diffusion test (ADT) and the direct-contact test (DCT). The antibacterial activity in ADT was measured based on the diameter of the zone of inhibition formed, whereas in DCT the density of the bacterial suspension was measured. The lower the density of the suspension, the more antibacterial activity the cement possesses...
December 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27942727/quantifying-the-burden-of-interhospital-cost-variation-in-pediatric-surgery-implications-for-the-prioritization-of-comparative-effectiveness-research
#13
Danielle B Cameron, Dionne A Graham, Carly E Milliren, Charity C Glass, Christina Feng, Feroze Sidhwa, Hariharan Thangarajah, Matthew Hall, Shawn J Rangel
Importance: Practice variation is believed to be a driver of excess health care spending, although few objective data exist to guide the prioritization of comparative effectiveness research (CER) in pediatric surgery. Objective: To identify high-priority general pediatric surgical procedures for CER on the basis of the following 2 complementary measures: the magnitude of interhospital cost variation as a surrogate for the need for and potential effect of CER at the patient level and the cumulative fiscal burden of this cost variation when considering the case volume from all hospitals as a surrogate for public health relevance...
December 12, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27942192/consensus-recommendation-for-india-and-bangladesh-for-the-use-of-pneumococcal-vaccine-in-mass-gatherings-with-special-reference-to-hajj-pilgrims
#14
Dilip Mathai, Abul Khair Mohammad Shamsuzzaman, Ahrar Ahmed Feroz, Amin R Virani, Ashfaq Hasan, K L Ravi Kumar, Khalid Ansari, Khandaker Atm Forhad Hossain, Mahesh Marda, M A Wahab Zubair, Mohammed Mukarram Ali, N Ashraf, Riyaz Basha, Shaeq Mirza, Shafeeq Ahmed, Shamim Akhtar, Syed Mustafa Ashraf, Zahirul Haque
Respiratory tract infections are prevalent among Hajj pilgrims with pneumonia being a leading cause of hospitalization. Streptococcus pneumoniae is a common pathogen isolated from patients with pneumonia and respiratory tract infections during Hajj. There is a significant burden of pneumococcal disease in India, which can be prevented. Guidelines for preventive measures and adult immunization have been published in India, but the implementation of the guidelines is low. Data from Bangladesh are available about significant mortality due to respiratory infections; however, literature regarding guidelines for adult immunization is limited...
October 2016: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/27939193/three-dimensional-echocardiographic-assessment-of-a-paravalvular-leak
#15
Andrew Maslow, Trevor Szymanski, Feroze Mahmood
No abstract text is available yet for this article.
September 28, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/27919723/three-dimensional-echocardiographic-assessment-of-coaptation-after-aortic-valve-repair
#16
Trevor Szymanski, Andrew Maslow, Feroze Mahmood, Arun Singh
No abstract text is available yet for this article.
September 28, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/27919718/intracardiac-mass-of-unknown-origin
#17
Jayant S Jainandunsing, Jelliffe Jeganathan, Thomas W L Scheeren, Arash Khamooshian, Ehsan Natour, Feroze Mahmood
No abstract text is available yet for this article.
September 16, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/27892818/interaction-of-stattic-a-stat3-inhibitor-with-human-serum-albumin-spectroscopic-and-computational-study
#18
Ida Syazwani M Affandi, Wei Qi Lee, Shevin R Feroz, Saharuddin B Mohamad, Saad Tayyab
No abstract text is available yet for this article.
December 26, 2016: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/27870650/surgical-answer-to-intralesional-steroid-induced-skin-atrophy
#19
Karalikkattil T Ashique, Feroze Kaliyadan
No abstract text is available yet for this article.
November 18, 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27865236/pcr-targeting-is6110-in-diagnosing-tuberculosis-in-children-in-comparison-to-mgit-culture
#20
Rajeshwar Dayal, Dipti Agarwal, Harish Pathak, Shehraj Feroz, Manoj Kumar, Devendra S Chauhan, Rakesh Bhatia
BACKGROUND: Diagnosis of tuberculosis (TB) in children is difficult in children especially in extrapulmonary tuberculosis (EPTB). This study was conducted to evaluate the use of polymerase chain reaction (PCR) targeting IS6110 in the diagnosis of TB in children with pulmonary TB and EPTB and also to compare its performance with MGIT 960 culture and conventional microscopy. METHODS: A total of 142 cases (50 pulmonary, 92 extrapulmonary) of suspected TB patients <15 years of age were included in the study...
July 2016: Indian Journal of Tuberculosis
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