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SPRINT Trial

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https://www.readbyqxmd.com/read/28642330/effects-of-intensive-bp-control-in-ckd
#1
Alfred K Cheung, Mahboob Rahman, David M Reboussin, Timothy E Craven, Tom Greene, Paul L Kimmel, William C Cushman, Amret T Hawfield, Karen C Johnson, Cora E Lewis, Suzanne Oparil, Michael V Rocco, Kaycee M Sink, Paul K Whelton, Jackson T Wright, Jan Basile, Srinivasan Beddhu, Udayan Bhatt, Tara I Chang, Glenn M Chertow, Michel Chonchol, Barry I Freedman, William Haley, Joachim H Ix, Lois A Katz, Anthony A Killeen, Vasilios Papademetriou, Ana C Ricardo, Karen Servilla, Barry Wall, Dawn Wolfgram, Jerry Yee
The appropriate target for BP in patients with CKD and hypertension remains uncertain. We report prespecified subgroup analyses of outcomes in participants with baseline CKD in the Systolic Blood Pressure Intervention Trial. We randomly assigned participants to a systolic BP target of <120 mm Hg (intensive group; n=1330) or <140 mm Hg (standard group; n=1316). After a median follow-up of 3.3 years, the primary composite cardiovascular outcome occurred in 112 intensive group and 131 standard group CKD participants (hazard ratio [HR], 0...
June 22, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28639443/relationship-between-the-handball-specific-complex-test-nonspecific-field-tests-and-the-match-performance-score-in-elite-professional-handball-players
#2
Souhail Hermassi, Mohamed S Chelly, Rainer Wollny, Birgit Hoffmeyer, Georg Fieseler, Stephan Schulze, Lars Irlenbusch, Karl-Stefan Delank, Roy J Shephard, Thomas Bartels, René Schwesig
BACKGROUND: This study assessed the validity of the handball-specific complex-test (HBCT) and two nonspecific field tests in professional elite handball athletes, using the match performance score (MPS) as the gold standard of performance. METHODS: Thirteen elite male handball players (age: 27.4 ± 4.8 years; premier German league) performed the HBCT, the Yo-Yo Intermittent Recovery Test (Yo-Yo-IR1-test) and a repeated shuttle sprint ability (RSA) test at the beginning of pre-season training...
June 21, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28623425/effects-of-a-20-week-high-intensity-strength-and-sprint-training-program-on-tibial-bone-structure-and-strength-in-middle-aged-and-older-male-sprint-athletes-a-randomized-controlled-trial
#3
T H Suominen, M T Korhonen, M Alén, A Heinonen, A Mero, T Törmäkangas, H Suominen
This randomized, controlled, high-intensity strength and sprint training trial in middle-aged and older male sprint athletes showed significant improvements in mid-tibial structure and strength. The study reveals the adaptability of aging bone, suggesting that through a novel, intensive training stimulus it is possible to strengthen bones during aging. INTRODUCTION: High-load, high-speed and impact-type exercise may be an efficient way of improving bone strength even in old age. We evaluated the effects of combined strength and sprint training on indices of bone health in competitive masters athletes, who serve as a group of older people who are likely to be able to participate in vigorous exercise of this kind...
June 16, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28623175/elevated-high-density-lipoprotein-cholesterol-is-associated-with-hyponatremia-in-hypertensive-patients
#4
Ariel Israel, Ehud Grossman
BACKGROUND: Recently, the Systolic Blood Pressure Intervention Trial (SPRINT) showed that intensive lowering of systolic blood pressure is beneficial, but is associated with more adverse events. Hyponatremia was notably more frequent in the intensive treatment group. Investigating its risk factors is crucial for preventing this complication. OBJECTIVE: To identify risk factors for hyponatremia in the adult population. METHODS: We investigated the baseline demographic, clinical and laboratory data from the 9,361 participants of SPRINT to identify the best predictors of hyponatremia (serum sodium ≤ 130mEq/L), and adverse events which could be attributed to hyponatremia, using machine learning and multivariable Cox proportional hazards models...
June 13, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28622081/effects-of-inspiratory-muscle-training-in-professional-women-football-players-a-randomized-sham-controlled-trial
#5
Bruno Archiza, Daniela Kuguimoto Andaku, Flávia Cristina Rossi Caruso, José Carlos Bonjorno, Cláudio Ricardo de Oliveira, Paula Angélica Ricci, André Capaldo do Amaral, Stela Márcia Mattiello, Cleiton Augusto Libardi, Shane A Phillips, Ross Arena, Audrey Borghi-Silva
This study was conducted to determine the effects of inspiratory muscle training (IMT) on respiratory and peripheral muscles oxygenation during a maximal exercise tolerance test and on repeated-sprint ability (RSA) performance in professional women football players. Eighteen athletes were randomly assigned to one of the following groups: SHAM (n = 8) or IMT (n = 10). After a maximal incremental exercise test, all participants performed (on a different day) a time-to-exhaustion (Tlim) test. Peripheral and respiratory muscles oxygenation by near-infrared spectroscopy, breath-by-breath ventilatory and metabolic variables, and blood lactate concentration were measured...
June 16, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28612327/the-j-shaped-curve-for-blood-pressure-and-cardiovascular-disease-risk-historical-context-and-recent-updates
#6
REVIEW
Faisal Rahman, John W McEvoy
PURPOSE OF REVIEW: The definition and treatment of hypertension have both changed dramatically over the last century, with recent trials suggesting benefit for lower blood pressure (BP) targets than ever before considered. However, tempering the enthusiasm for more intensive BP targets are long-held concerns that BP reduction below a certain threshold may pose dangers, the so-called "J-curve." In this review, we summarize the evidence for a J-curve in the treatment of hypertension. RECENT FINDINGS: The Systolic Blood Pressure Intervention Trial (SPRINT) reported that achieving a systolic BP target of 120 mmHg reduces cardiovascular disease in high-risk individuals, supporting more intensive BP reduction...
August 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28606731/cognitive-function-and-kidney-disease-baseline-data-from-the%C3%A2-systolic-blood-pressure-intervention-trial-sprint
#7
Daniel E Weiner, Sarah A Gaussoin, John Nord, Alexander P Auchus, Gordon J Chelune, Michel Chonchol, Laura Coker, William E Haley, Anthony A Killeen, Paul L Kimmel, Alan J Lerner, Suzanne Oparil, Mohammad G Saklayen, Yelena M Slinin, Clinton B Wright, Jeff D Williamson, Manjula Kurella Tamura
BACKGROUND: Chronic kidney disease is common and is associated with cardiovascular disease, cerebrovascular disease, and cognitive function, although the nature of this relationship remains uncertain. STUDY DESIGN: Cross-sectional cohort using baseline data from the Systolic Blood Pressure Intervention Trial (SPRINT). SETTING & PARTICIPANTS: Participants in SPRINT, a randomized clinical trial of blood pressure targets in older community-dwelling adults with cardiovascular disease, chronic kidney disease, or high cardiovascular disease risk and without diabetes or known stroke, who underwent detailed neurocognitive testing in the cognition substudy, SPRINT-Memory and Cognition in Decreased Hypertension (SPRINT-MIND)...
June 9, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28602550/examining-the-applicability-of-sprint-in-patients-with-subclinical-or-established-atherothrombotic-disease-a-reach-registry-analysis
#8
Anubodh Varshney, Ph Gabriel Steg, Yedid Elbez, Emmanuel Sorbets, Kim A Eagle, Deepak L Bhatt
BACKGROUND: The optimal blood pressure (BP) target to reduce the risk of cardiovascular (CV) events remains uncertain, especially in patients with coronary artery disease (CAD). Results from the Systolic Blood Pressure Intervention Trial (SPRINT) suggest that targeting a systolic BP<120mmHg decreases the rate of death and CV events in patients with hypertension and increased CV risk. We sought to evaluate the real-world applicability of SPRINT to patients with atherothrombosis. METHODS: We divided 35,411 hypertensive patients from the REACH registry into SPRINT-eligible and SPRINT-ineligible based on the trial's inclusion and exclusion criteria...
June 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28597616/comparison-of-the-movement-patterns-between-small-and-large-side-games-training-and-competition-in-professional-soccer-players
#9
Jesús V Giménez, Juan Del-Coso, Anthony S Leicht, Miguel A Gomez
BACKGROUND: The purpose of this investigation was to compare the movement patterns of professional soccer players during a small-sided game (SSG), a large-sided game (LSG) and a competitive friendly match (FM). METHODS: Fourteen professional players participated in three training routines with a similar relative pitch area per player. The SSG and LSG consisted of 8 repetitions of 4-min game play, interspersed by 2-min of active recovery, and their data were compared to the first 32 minutes of a FM...
June 8, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28593095/load-enhanced-movement-quality-screening-and-tactical-athleticism-an-extension-of-evidence
#10
Stephen M Glass, Randy J Schmitz, Christopher K Rhea, Scott E Ross
BACKGROUND: Military organizations use movement quality screening for prediction of injury risk and performance potential. Currently, evidence of an association between movement quality and performance is limited. Recent work has demonstrated that external loading strengthens the relationship between movement screens and performance outcomes. Such loading may therefore steer us toward robust implementations of movement quality screens while maintaining their appeal as cost effective, field-expedient tools...
June 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28579190/effect-of-low-level-laser-therapy-lllt-and-light-emitting-diodes-ledt-applied-during-combined-training-on-performance-and-post-exercise-recovery-protocol-for-a-randomized-placebo-controlled-trial
#11
Aryane Flauzino Machado, Jéssica Kirsch Micheletti, Franciele Marques Vanderlei, Fabio Yuzo Nakamura, Ernesto Cesar Pinto Leal-Junior, Jayme Netto Junior, Carlos Marcelo Pastre
BACKGROUND: Previous studies have shown positive results of phototherapy for improving performance and accelerating recovery; however, the effects of phototherapy during training and after a primary adaptation remain unclear. The aim of this randomized controlled trial is to analyze the effects of phototherapy and combined training on clinical, functional, and psychological outcomes and on vascular endothelial growth factor. METHODS: This randomized placebo-controlled trial by stratified sample will involve 45 healthy male participants...
May 20, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28572782/timing-of-gun-fire-influences-sprinters-multiple-joint-reaction-times-of-whole-body-in-block-start
#12
Mitsuo Otsuka, Toshiyuki Kurihara, Tadao Isaka
Experienced sprinters are specifically adapted to pre-planning an advanced motor program. Herein, sprinters are able to immediately accelerate their center of mass forward with a whole-body coordinated motion, following a steady state crouched position. We examined the effect of variable timing of reaction signals on multiple joint reaction times (RT) and whole-body RT for specialist sprinters. Twenty well-experienced male sprinters performed five start-dashes from a block start under five variable foreperiod (FP) length conditions (1...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28559651/the-2017-focused-update-of-the-guidelines-of-the-taiwan-society-of-cardiology-tsoc-and-the-taiwan-hypertension-society-ths-for-the-management-of-hypertension
#13
REVIEW
Chern-En Chiang, Tzung-Dau Wang, Tsung-Hsien Lin, Hung-I Yeh, Ping-Yen Liu, Hao-Min Cheng, Ting-Hsing Chao, Chen-Huan Chen, Kou-Gi Shyu, Kwo-Chang Ueng, Chung-Yin Chen, Pao-Hsien Chu, Shih-Hsien Sung, Kang-Ling Wang, Yi-Heng Li, Kuo-Yang Wang, Fu-Tien Chiang, Wen-Ter Lai, Jyh-Hong Chen, Wen-Jone Chen, San-Jou Yeh, Ming-Fong Chen, Shing-Jong Lin, Jiunn-Lee Lin
Hypertension (HT) is the most important risk factor for cardiovascular diseases. Over the past 25 years, the number of individuals with hypertension and the estimated associated deaths has increased substantially. There have been great debates in the past few years on the blood pressure (BP) targets. The 2013 European Society of Hypertension and European Society of Cardiology HT guidelines suggested a unified systolic BP target of 140 mmHg for both high-risk and low-risk patients. The 2014 Joint National Committee report further raised the systolic BP targets to 150 mmHg for those aged ≥ 60 years, including patients with stroke or coronary heart disease, and raised the systolic BP target to 140 mmHg for diabetes...
May 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/28557858/effects-of-combined-strength-and-sprint-training-on-lean-mass-strength-power-and-sprint-performance-in-masters-road-cyclists
#14
Luke Del Vecchio, Robert Stanton, Peter Reaburn, Campbell Macgregor, Jarrod Meerkin, Jerome Villegas, Marko T Korhonen
Strength and sprint training exercises are integral part of training in many younger endurance cyclists to improve cycling efficiency and sprinting ability. This study was undertaken to examine whether muscle and performance characteristics could be improved in endurance-trained masters cyclist by adding strength and sprint training stimuli into their training regimen. Twenty five masters road cyclists were assigned to a combined strength and sprint training group (CT; n=9, 53.5 ± 9.3 years), a sprint training group (ST, n=7, 49...
May 25, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28544636/visit-to-visit-systolic-blood-pressure-variability-predicts-treatment-related-adverse-event-of-hyponatremia-in-sprint
#15
Abhinav Goyal, Kenechukwu Mezue, Janani Rangaswami
Hypertension is a common condition and an important cardiovascular risk factor. SPRINT trial showed that the beneficial effects of targeting systolic blood pressure <120 mmHg were accompanied by more adverse events. De-identified SPRINT database was used for this analysis. All subjects in each group that achieved their respective target blood pressure (<120, intensive; <140, standard) were included. Only readings after reaching target blood pressure for the first time were included. Subjects that never reached target or had <2 readings upon reaching target were excluded...
May 25, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28529721/the-impact-of-antihypertensives-on-kidney-disease
#16
REVIEW
Diego F Marquez, Gema Ruiz-Hurtado, Luis Ruilope
Arterial hypertension and chronic kidney disease (CKD) are intimately related. The control of blood pressure (BP) levels is strongly recommended in patients with CKD in order to protect the kidney against the accompanying elevation in global cardiovascular (CV) risk. Actually, the goal BP in patients with CKD involves attaining values <140/90 mmHg except if albuminuria is present. In this case, it is often recommended to attain values <130/80 mmHg, although some guidelines still recommend <140/90 mmHg...
2017: F1000Research
https://www.readbyqxmd.com/read/28527424/influence-of-chronic-stretching-on-muscle-performance-systematic-review
#17
D M Medeiros, C S Lima
The aim of the current study was to investigate the influence of chronic stretching on muscle performance (MP) by a systematic review. The search strategy included MEDLINE, PEDro, Cochrane CENTRAL, LILACS, and manual search from inception to June 2016. Randomized and controlled clinical trials, non-randomized, and single group studies that have analyzed the influence of flexibility training (FT) (using any stretching technique) on MP were included. Differently, studies with special populations (children, elderly, and people with any dysfunction/disease), and articles that have used FT protocols shorter than three weeks or 12 sessions were excluded...
May 17, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28512184/effect-of-intensive-blood-pressure-lowering-on-left-ventricular-hypertrophy-in-patients-with-hypertension-the-systolic-blood-pressure-intervention-sprint-trial
#18
Elsayed Z Soliman, Walter T Ambrosius, William C Cushman, Zhu-Ming Zhang, Jeffrey T Bates, Javier A Neyra, Thaddeus Y Carson, Leonardo Tamariz, Lama Ghazi, Monique E Cho, Brian P Shapiro, Jiang He, Lawrence J Fine, Cora E Lewis
Background -It is currently unknown whether intensive blood pressure (BP) lowering beyond that recommended would lead to more lowering of the risk of Left ventricular hypertrophy (LVH) in patients with hypertension, and whether reducing the risk of LVH explains the reported cardiovascular disease (CVD) benefits of intensive BP lowering in this population. Methods -This analysis included 8,164 participants (mean age 67.9 years, 35.3% women, 31.2% blacks) with hypertension but no diabetes from the Systolic Blood Pressure Intervention (SPRINT) Trial; 4,086 randomly assigned to intensive BP lowering (target systolic BP<120mmHg) and 4,078 assigned to standard BP lowering (target systolic BP <140mmHg)...
May 16, 2017: Circulation
https://www.readbyqxmd.com/read/28508114/oral-l-menthol-reduces-thermal-sensation-increases-work-rate-and-extends-time-to-exhaustion-in-the-heat-at-a-fixed-rating-of-perceived-exertion
#19
T R Flood, M Waldron, O Jeffries
PURPOSE: The study investigated the effect of a non-thermal cooling agent, L-menthol, on exercise at a fixed subjective rating of perceived exertion (RPE) in a hot environment. METHOD: Eight male participants completed two trials at an exercise intensity between 'hard' and 'very hard', equating to 16 on the RPE scale at ~35 °C. Participants were instructed to continually adjust their power output to maintain an RPE of 16 throughout the exercise trial, stopping once power output had fallen by 30%...
May 15, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28492286/has-the-sprint-trial-introduced-a-new-blood-pressure-goal-in-hypertension
#20
REVIEW
Gema Ruiz-Hurtado, José R Banegas, Pantelis A Sarafidis, Massimo Volpe, Bryan Williams, Luis M Ruilope
SPRINT is the first randomized, controlled trial showing that a systolic blood-pressure goal of <120 mmHg can be attained with cardiovascular benefits in a select group of patients with hypertension and an elevated cardiovascular risk with different origins. Although the patient population with characteristics like those in SPRINT makes up only 20-30% of the total hypertensive population, SPRINT is a landmark study that highlights the need to consider lower blood- pressure goals in the treatment of hypertension...
May 11, 2017: Nature Reviews. Cardiology
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