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SPRINT Trial

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https://www.readbyqxmd.com/read/28902109/validity-and-reliability-of-the-stages-cycling-power-meter
#1
Cyril Granier, Christophe Hausswirth, Sylvain Dorel, Le Meur Yann
PURPOSE: This study aimed to determine the validity and the reliability of the Stages power meter crank system (Boulder, United States) during several laboratory cycling tasks. METHODS: Eleven trained participants completed laboratory cycling trials on an indoor cycle fitted with SRM Professional and Stages systems. The trials consisted of an incremental test at 100W, 200W, 300W, 400W and four 7s sprints. The level of pedaling asymmetry was determined for each cycling intensity during a similar protocol completed on a Lode Excalibur Sport ergometer...
September 6, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28893522/systolic-blood-pressure-target-in-systemic-arterial-hypertension-is-lower-ever-better-results-from-a-community-based-caucasian-cohort
#2
Concetta Di Nora, Giovanni Cioffi, Annamaria Iorio, Luigi Rivetti, Stefano Poli, Elena Zambon, Giulia Barbati, Gianfranco Sinagra, Andrea Di Lenarda
BACKGROUND: Extensive evidence exists about the prognostic role of systolic blood pressure (SBP) reduction ≤140mmHg. Recently, the SPRINT trial successfully tested the strategy of lowering SBP<120mmHg in patients with arterial hypertension (AH). AIM: To assess whether the SPRINT results are reproducible in a real world community population. METHODS: Cross-sectional, population-based study analyzing data of 24,537 Caucasian people with AH from the Trieste Observatory of CV disease, 2010 to 2015...
September 8, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28887862/systolic-blood-pressure-targets-diastolic-j-curve-and-cuff-artefact-in-blood-pressure-measurement-a-note-of-caution
#3
J David Spence
There is good evidence that controlling hypertension reduces the risk of stroke and other cardiovascular consequences of hypertension. The recent Systolic Blood Pressure Intervention Trial (SPRINT) trial, stopped early because of a higher risk among participants randomized to the higher blood pressure target, will no doubt lead to calls for even lower pressures. Even among participants age ≥75, those randomized to a target systolic blood pressure (SBP) < 120 mmHg had a lower risk of stroke and cardiovascular events compared with a SBP target <140 mmHg[1]...
September 8, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28885961/effectiveness-of-ice-sheet-cooling-following-exertional-hyperthermia
#4
Cory L Butts, Debora L Spisla, J D Adams, Cody R Smith, Kathleen M Paulsen, Aaron R Caldwell, Matthew S Ganio, Brendon P McDermott
BACKGROUND: The procedure of wrapping a heat casualty in ice-water soaked bed sheets to reduce core temperature has received little investigation, despite the practice and recommendation for its use in some military settings. Thus, the purpose of this study was to investigate the cooling efficacy of ice-sheet cooling (ISC) following exertional hyperthermia. METHODS: 13 (11 males, 2 females) participants (age = 23 ± 3 years, height = 176.5 ± 10.3 cm, mass = 78...
September 2017: Military Medicine
https://www.readbyqxmd.com/read/28869987/effects-of-intensive-systolic-blood-pressure-control-on-kidney-and-cardiovascular-outcomes-in-persons-without-kidney-disease-a-secondary-analysis-of-a-randomized-trial
#5
Srinivasan Beddhu, Michael V Rocco, Robert Toto, Timothy E Craven, Tom Greene, Udayan Bhatt, Alfred K Cheung, Debbie Cohen, Barry I Freedman, Amret T Hawfield, Anthony A Killeen, Paul L Kimmel, James Lash, Vasilios Papademetriou, Mahboob Rahman, Anjay Rastogi, Karen Servilla, Raymond R Townsend, Barry Wall, Paul K Whelton
Background: The public health significance of the reported higher incidence of chronic kidney disease (CKD) with intensive systolic blood pressure (SBP) lowering is unclear. Objective: To examine the effects of intensive SBP lowering on kidney and cardiovascular outcomes and contrast its apparent beneficial and adverse effects. Design: Subgroup analyses of SPRINT (Systolic Blood Pressure Intervention Trial). (ClinicalTrials.gov: NCT01206062)...
September 19, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28866864/the-association-between-insulin-resistance-and-atrial-fibrillation-a-cross-sectional-analysis-from-sprint-systolic-blood-pressure-intervention-trial
#6
Monique E Cho, Timothy E Craven, Alfred K Cheung, Stephen P Glasser, Mahboob Rahman, Elsayed Z Soliman, Randall S Stafford, Karen C Johnson, Jeffrey T Bates, Anna Burgner, Addison A Taylor, Leonardo Tamariz, Rocky Tang, Srinivasan Beddhu
It is unclear whether metabolic syndrome (MetS) is associated with atrial fibrillation (AF) in an older population with greater cardiovascular risk, including those with chronic kidney disease. The authors investigated the association between MetS and AF in participants in SPRINT (Systolic Blood Pressure Intervention Trial). MetS was defined based on the Modified Third National Cholesterol Education Program. The baseline prevalence rate for MetS was 55%, while 8.2% of the participants had AF. In multivariate regression analyses, AF was not associated with presence of MetS in either chronic kidney disease or non-chronic kidney disease subgroups...
September 3, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28841431/diastolic-hypotension-due-to-intensive-blood-pressure-therapy-is-it-harmful
#7
Mats Julius Stensrud, Susanne Strohmaier
BACKGROUND AND AIMS: Reducing the diastolic blood pressure (DBP) below a certain threshold may lead to inadequate organ perfusion. This raises some concerns, because pharmacotherapy reduces both systolic and diastolic pressure. We aimed to investigate whether a pathway from intensive systolic blood pressure (SBP) treatment influences cardiovascular outcomes by inducing too low DBP. METHODS: We had access to data from the Systolic Blood Pressure Intervention Trial (SPRINT) including 9361 patients with a SBP of 130 mmHg or higher and an increased cardiovascular risk...
July 24, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28840263/closed-loop-glucose-control-in-young-people-with-type-1-diabetes-during-and-after-unannounced-physical-activity-a-randomised-controlled-crossover-trial
#8
Klemen Dovc, Maddalena Macedoni, Natasa Bratina, Dusanka Lepej, Revital Nimri, Eran Atlas, Ido Muller, Olga Kordonouri, Torben Biester, Thomas Danne, Moshe Phillip, Tadej Battelino
AIMS/HYPOTHESIS: Hypoglycaemia during and after exercise remains a challenge. The present study evaluated the safety and efficacy of closed-loop insulin delivery during unannounced (to the closed-loop algorithm) afternoon physical activity and during the following night in young people with type 1 diabetes. METHODS: A randomised, two-arm, open-label, in-hospital, crossover clinical trial was performed at a single site in Slovenia. The order was randomly determined using an automated web-based programme with randomly permuted blocks of four...
August 24, 2017: Diabetologia
https://www.readbyqxmd.com/read/28834483/effect-of-intensive-blood-pressure-treatment-on-patient-reported-outcomes
#9
Dan R Berlowitz, Capri G Foy, Lewis E Kazis, Linda P Bolin, Molly B Conroy, Peter Fitzpatrick, Tanya R Gure, Paul L Kimmel, Kent Kirchner, Donald E Morisky, Jill Newman, Christine Olney, Suzanne Oparil, Nicholas M Pajewski, James Powell, Thomas Ramsey, Debra L Simmons, Joni Snyder, Mark A Supiano, Daniel E Weiner, Jeff Whittle
BACKGROUND: The previously published results of the Systolic Blood Pressure Intervention Trial showed that among participants with hypertension and an increased cardiovascular risk, but without diabetes, the rates of cardiovascular events were lower among those who were assigned to a target systolic blood pressure of less than 120 mm Hg (intensive treatment) than among those who were assigned to a target of less than 140 mm Hg (standard treatment). Whether such intensive treatment affected patient-reported outcomes was uncertain; those results from the trial are reported here...
August 24, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28834469/cost-effectiveness-of-intensive-versus-standard-blood-pressure-control
#10
Adam P Bress, Brandon K Bellows, Jordan B King, Rachel Hess, Srinivasan Beddhu, Zugui Zhang, Dan R Berlowitz, Molly B Conroy, Larry Fine, Suzanne Oparil, Donald E Morisky, Lewis E Kazis, Natalia Ruiz-Negrón, Jamie Powell, Leonardo Tamariz, Jeff Whittle, Jackson T Wright, Mark A Supiano, Alfred K Cheung, William S Weintraub, Andrew E Moran
BACKGROUND: In the Systolic Blood Pressure Intervention Trial (SPRINT), adults at high risk for cardiovascular disease who received intensive systolic blood-pressure control (target, <120 mm Hg) had significantly lower rates of death and cardiovascular disease events than did those who received standard control (target, <140 mm Hg). On the basis of these data, we wanted to determine the lifetime health benefits and health care costs associated with intensive control versus standard control...
August 24, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28830536/the-preventive-effect-of-the-bounding-exercise-programme-on-hamstring-injuries-in-amateur-soccer-players-the-design-of-a-randomized-controlled-trial
#11
S Van de Hoef, B M A Huisstede, M S Brink, N de Vries, E A Goedhart, F J G Backx
BACKGROUND: Hamstring injuries are the most common muscle injury in amateur and professional soccer. Most hamstring injuries occur in the late swing phase, when the hamstring undergoes a stretch-shortening cycle and the hamstring does a significant amount of eccentric work. The incidence of these injuries has not decreased despite there being effective injury prevention programmes focusing on improving eccentric hamstring strength. As this might be because of poor compliance, a more functional injury prevention exercise programme that focuses on the stretch-shortening cycle might facilitate compliance...
August 22, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28828478/association-of-jnc-8-and-sprint-systolic-blood-pressure-levels-with-cognitive-function-and-related-racial-disparity
#12
Ihab Hajjar, Kristine J Rosenberger, Ambar Kulshreshtha, Hilsa N Ayonayon, Kristine Yaffe, Felicia C Goldstein
Importance: The Eighth Joint National Committee (JNC-8) recommended treating systolic blood pressure (SBP) to a target below 150 mm Hg in older adults, whereas data from the Systolic Blood Pressure Intervention Trial (SPRINT) suggested that a SBP level of lower than 120 mm Hg decreases cardiovascular event rates. Target SBP guidelines have not addressed the potential that black patients may have greater morbidity and mortality from hypertension, especially with regard to cognitive outcomes...
August 21, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28828081/effects-of-plyometric-training-and-beta-alanine-supplementation-on-maximal-intensity-exercise-and-endurance-in-female-soccer-players
#13
Fabián Rosas, Rodrigo Ramírez-Campillo, Cristian Martínez, Alexis Caniuqueo, Rodrigo Cañas-Jamet, Emma McCrudden, Cesar Meylan, Jason Moran, Fábio Y Nakamura, Lucas A Pereira, Irineu Loturco, Daniela Diaz, Mikel Izquierdo
Plyometric training and beta-alanine supplementation are common among soccer players, although its combined use had never been tested. Therefore, a randomized, double-blind, placebo-controlled trial was conducted to compare the effects of a plyometric training program, with or without beta-alanine supplementation, on maximal-intensity and endurance performance in female soccer players during an in-season training period. Athletes (23.7 ± 2.4 years) were assigned to either a plyometric training group receiving a placebo (PLACEBO, n = 8), a plyometric training group receiving beta-alanine supplementation (BA, n = 8), or a control group receiving placebo without following a plyometric training program (CONTROL, n = 9)...
September 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28806275/effects-of-creatine-and-carbohydrate-loading-on-cycling-time-trial-performance
#14
Kristyen A Tomcik, Donny M Camera, Julia L Bone, Megan L Ross, Nikki A Jeacocke, Bill Tachtsis, Joan Senden, Luc J C van Loon, John A Hawley, Louise M Burke
INTRODUCTION: Creatine- and carbohydrate-loading are dietary strategies used to enhance exercise capacity. This study examined the metabolic and performance effects of a combined creatine and CHO-loading regiment on time-trial (TT) cycling bouts. METHODS: Eighteen well-trained (~65mL[BULLET OPERATOR]kg[BULLET OPERATOR]min VO2peak) males completed three performance trials (PT) comprised of a 120-km cycling TT interspersed with alternating 1- and 4-km sprints (6 sprints each) performed every 10-km followed by an inclined ride to fatigue (~90% VO2peak)...
August 11, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28806100/including-the-copenhagen-adduction-exercise-in-the-fifa-11-provides-missing-eccentric-hip-adduction-strength-effect-in-male-soccer-players-a-randomized-controlled-trial
#15
Joar Harøy, Kristian Thorborg, Andreas Serner, André Bjørkheim, Linn E Rolstad, Per Hölmich, Roald Bahr, Thor Einar Andersen
BACKGROUND: The FIFA 11+ was developed as a complete warm-up program to prevent injuries in soccer players. Although reduced hip adduction strength is associated with groin injuries, none of the exercises included in the FIFA 11+ seem to specifically target hip adduction strength. PURPOSE: To investigate the effect on eccentric hip adduction strength of the FIFA 11+ warm-up program with or without the Copenhagen adduction exercise. STUDY DESIGN: Randomized controlled trial; Level of evidence, 1...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28801751/activity-demands-during-multi-directional-team-sports-a-systematic-review
#16
REVIEW
Jeffrey B Taylor, Alexis A Wright, Steven L Dischiavi, M Allison Townsend, Adam R Marmon
BACKGROUND: Late-stage rehabilitation programs often incorporate 'sport-specific' demands, but may not optimally simulate the in-game volume or intensity of such activities as sprinting, cutting, jumping, and lateral movement. OBJECTIVE: The aim of this review was to characterize, quantify, and compare straight-line running and multi-directional demands during sport competition. DATA SOURCES: A systematic review of PubMed, CINAHL, SPORTDiscus, and Cochrane Central Register of Controlled Trials databases was conducted...
August 12, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28793997/effect-of-intensive-versus-standard-blood-pressure-treatment-according-to-baseline-prediabetes-status-a-post-hoc-analysis-of-a-randomized-trial
#17
Adam P Bress, Jordan B King, Kathryn E Kreider, Srinivasan Beddhu, Debra L Simmons, Alfred K Cheung, Yingying Zhang, Michael Doumas, John Nord, Mary Ellen Sweeney, Addison A Taylor, Charles Herring, William J Kostis, James Powell, Anjay Rastogi, Christianne L Roumie, Alan Wiggers, Jonathan S Williams, Reem Yunis, Athena Zias, Greg W Evans, Tom Greene, Michael V Rocco, William C Cushman, David M Reboussin, Mark N Feinglos, Vasilios Papademetriou
OBJECTIVE: To determine whether the effects of intensive (<120 mmHg) compared with standard (<140 mmHg) systolic blood pressure (SBP) treatment are different among those with prediabetes versus those with fasting normoglycemia at baseline in the Systolic Blood Pressure Intervention Trial (SPRINT). RESEARCH DESIGN AND METHODS: This was a post hoc analysis of SPRINT. SPRINT participants were categorized by prediabetes status, defined as baseline fasting serum glucose ≥100 mg/dL versus those with normoglycemia (fasting serum glucose <100 mg/dL)...
August 9, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28777249/isometric-mid-thigh-pull-performance-is-associated-with-athletic-performance-and-sprinting-kinetics-in-division-i-men-and-women-s-basketball-players
#18
Jeremy R Townsend, David Bender, William Vantrease, John Hudy, Kevin Huet, Cassie Williamson, Emily Bechke, Paul Serafini, Gerald T Mangine
PURPOSE: To examine the relationships between isometric mid-thigh pull (IMTP) force, athletic performance measures, and sprint kinetics in Division I men's and women's basketball players. METHODS: Twenty-three (male = 8, female = 15) division 1 basketball players completed a maximal 20-m sprint trial while tethered to a device which provided kinetic feedback (peak and average sprinting power, velocity and force). Additionally, one repetition-maximal (1RM) front squat, 1RM hang clean, vertical jump height, and agility (pro-agility and lane agility) tests were performed...
July 31, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28771064/vitamin-d3-supplementation-does-not-improve-sprint-performance-in-professional-rugby-players-a-randomised-placebo-controlled-double-blind-intervention-study
#19
Kirsty A Fairbairn, Ingrid Jm Ceelen, C Murray Skeaff, Claire M Cameron, Tracy L Perry
Vitamin D insufficiency is common in athletes and may lower physical performance. Many cross-sectional studies associate vitamin D status with physical performance in athletes, however there have been few prospective randomised controlled trials with adequate statistical power to test this relationship, and none in the southern hemisphere. Thus, a prospective double blind, randomised placebo-controlled intervention trial was conducted, involving 57 professional rugby union players in New Zealand. Participants were randomised to receive 50,000 IU of cholecalciferol (equivalent to 3,570 IU/day) or placebo once every two weeks over 11-12 weeks...
August 3, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/28767317/effects-of-inter-limb-asymmetries-on-physical-and-sports-performance-a-systematic-review
#20
Chris Bishop, Anthony Turner, Paul Read
The prevalence of inter-limb asymmetries has been reported in numerous studies across a wide range of sports and physical qualities; however, few have analysed their effects on physical and sports performance. A systematic review of the literature was undertaken using the Medline and SPORT Discus databases, with all articles required to meet a specified criteria based on a quality review. Eighteen articles met the inclusion criteria, relating participant asymmetry scores to physical and sports performance measures...
August 2, 2017: Journal of Sports Sciences
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