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SPRINT Trial

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https://www.readbyqxmd.com/read/28193605/potential-deaths-averted-and-serious-adverse-events-incurred-from-adoption-of-the-sprint-intensive-blood-pressure-regimen-in-the-u-s-projections-from-nhanes
#1
Adam P Bress, Holly Kramer, Rasha Khatib, Srinivasan Beddhu, Alfred K Cheung, Rachel Hess, Vinod K Bansal, Guichan Cao, Jerry Yee, Andrew E Moran, Ramon A Durazo-Arvizu, Paul Muntner, Richard S Cooper
Background -The Systolic Blood Pressure Intervention Trial (SPRINT) demonstrated a 27% reduction in all-cause mortality with a systolic blood-pressure (SBP) goal of <120 mmHg versus <140 mmHg among U.S. adults at high cardiovascular disease (CVD) risk but without diabetes, stroke, or heart failure. To quantify the potential benefits and risks of SPRINT intensive goal implementation, we estimated the deaths prevented and excess serious adverse events (SAEs) incurred if the SPRINT intensive SBP treatment goal was implemented in all eligible U...
February 13, 2017: Circulation
https://www.readbyqxmd.com/read/28183441/similar-metabolic-response-to-lower-versus-upper-body-interval-exercise-or-endurance-exercise
#2
Monique E Francois, Matthew J Graham, Evelyn B Parr, Nancy J Rehrer, Samuel J E Lucas, Stasinos Stavrianeas, James D Cotter
PURPOSE: To compare energy use and substrate partitioning arising from repeated lower- versus upper-body sprints, or endurance exercise, across a 24-h period. METHODS: Twelve untrained males (24±4 y) completed three trials in randomized order: (1) repeated sprints (five 30-s Wingate, 4.5-min recovery) on a cycle ergometer (SITLegs); (2) 50-min continuous cycling at 65% V̇O2max (END); (3) repeated sprints on an arm-crank ergometer (SITArms). Respiratory gas exchange was assessed before and during exercise, and at eight points across 22h of recovery...
March 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28182508/effects-of-carbohydrate-ingestion-and-carbohydrate-mouth-rinse-on-repeat-sprint-performance
#3
Ben M Krings, Timothy J Peterson, Brandon D Shepherd, Matthew J McAllister, JohnEric W Smith
The purpose of this investigation was to examine to the influence of carbohydrate ingestion (CHOI) and carbohydrate mouth rinse (CHOR) on acute repeat maximal sprint performance. Fourteen healthy males (age: 21.7 ± 1.8 years, mass: 82.3 ± 12.3 kg) completed a total of five 15-second maximal repeat sprints on a cycle ergometer against 0.075 kg . kg(-1) body mass each separated by four minutes of active recovery. Subjects completed four experimental trials and were randomly assigned one of four treatments: (1) CHOI, (2) CHOR, (3) placebo mouth rinse (PLAR), (4) placebo ingestion (PLAI)...
February 9, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/28177733/the-effects-of-block-training-on-pacing-during-20-km-cycling-time-trial
#4
Vitor Pereira Costa, Luiz Guilherme Antonacci Guglielmo, Carl David Paton
The aim of this study was to determine the effects of block training (BL) on pacing during a 20-km hilly cycling time trial (TT) in trained cyclists. Twenty male cyclists were separated into two groups: control and BL. The training of each cyclist was monitored during a period of 3 weeks. In the first week cyclists performed an overload period of seven consecutive days of high intensity interval training followed by two weeks of normal training. Cyclists performed one TT before intervention and two TT after seven and fourteen days at the end of training...
December 15, 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28174540/the-influence-of-mid-event-deception-on-psychophysiological-status-and-pacing-can-persist-across-consecutive-disciplines-and-enhance-self-paced-multi-modal-endurance-performance
#5
Daniel Taylor, Mark F Smith
Purpose: To examine the effects of deceptively aggressive bike pacing on performance, pacing, and associated physiological and perceptual responses during simulated sprint-distance triathlon. Methods: Ten non-elite, competitive male triathletes completed three simulated sprint-distance triathlons (0.75 km swim, 500 kJ bike, 5 km run), the first of which established personal best "baseline" performance (BL). During the remaining two trials athletes maintained a cycling power output 5% greater than BL, before completing the run as quickly as possible...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28166324/effect-of-intensive-blood-pressure-control-on-gait-speed-and-mobility-limitation-in-adults-75-years-or-older-a-randomized-clinical-trial
#6
Michelle C Odden, Carmen A Peralta, Dan R Berlowitz, Karen C Johnson, Jeffrey Whittle, Dalane W Kitzman, Srinivasan Beddhu, John W Nord, Vasilios Papademetriou, Jeff D Williamson, Nicholas M Pajewski
Importance: Intensive blood pressure (BP) control confers a benefit on cardiovascular morbidity and mortality; whether it affects physical function outcomes is unknown. Objective: To examine the effect of intensive BP control on changes in gait speed and mobility status. Design, Setting, and Participants: This randomized, clinical trial included 2636 individuals 75 years or older with hypertension and no history of type 2 diabetes or stroke who participated in the Systolic Blood Pressure Intervention Trial (SPRINT)...
February 6, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28161697/in-the-wake-of-systolic-blood-pressure-intervention-trial-new-targets-for-improving-hypertension-management-in-chronic-kidney-disease
#7
Crystal C Tyson, Thomas M Coffman
Systolic Blood Pressure Intervention Trial (SPRINT) was a multicenter randomized controlled trial showing the significant benefit of intensive reduction of blood pressure to a target of 120 mm Hg in individuals with hypertension and elevated cardiovascular risk. Because SPRINT includes the largest cohort of adults with chronic kidney disease (CKD) to be prospectively studied in a hypertension intervention trial, it has particular relevance to the field of nephrology. Here, we review the findings of SPRINT and assess their potential impact on guidelines for treatment of hypertension in patients with CKD...
February 4, 2017: Nephron
https://www.readbyqxmd.com/read/28160084/neuromuscular-adaptations-to-sprint-interval-training-and-the-effect-of-mammalian-omega-3-fatty-acid-supplementation
#8
Evan J H Lewis, Frédéric Stucky, Peter W Radonic, Adam H Metherel, Thomas M S Wolever, Greg D Wells
PURPOSE: Sprint interval training (SIT) stimulates rapid metabolic adaptations within skeletal muscle but the nature of neuromuscular adaptions is unknown. Omega-3 polyunsaturated fatty acids (N-3 PUFA) are suggested to enhance neuromuscular adaptations to exercise. METHODS: We measured the neuromuscular adaptations to SIT (Study-1) and conducted a placebo-controlled randomized double blinded study to determine the effect of N-3 PUFA supplementation on neuromuscular adaptations to SIT (Study-2)...
February 3, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28159816/implications-of-blood-pressure-measurement-technique-for-implementation-of-systolic-blood-pressure-intervention-trial-sprint
#9
Rajiv Agarwal
BACKGROUND: Cardiovascular morbidity and mortality was reduced by 25% when blood pressure (BP) was targeted to 120 mm Hg systolic compared with 140 mm Hg systolic in Systolic Blood Pressure Intervention Trial (SPRINT); however, BP was measured using a research technique. SPRINT specified 5 minutes of seated rest in a quiet room followed by 3 oscillometric measurements without an observer in the room. The relationship of this research-grade methodology to routine BP measurements is not known...
February 3, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28150178/the-effect-of-concurrent-plyometric-training-versus-submaximal-aerobic-cycling-on-rowing-economy-peak-power-and-performance-in-male-high-school-rowers
#10
Julian D Egan-Shuttler, Rohan Edmonds, Cassandra Eddy, Veronica O'Neill, Stephen J Ives
BACKGROUND: Plyometric training has been shown to increase muscle power, running economy, and performance in athletes. Despite its use by rowing coaches, it is unknown whether plyometrics might improve rowing economy or performance. The purpose was to determine if plyometric training, in conjunction with training on the water, would lead to improved rowing economy and performance. METHODS: Eighteen male high school rowers were assigned to perform 4 weeks of either plyometric training (PLYO, n = 9) or steady-state cycling below ventilatory threshold (endurance, E, n = 9), for 30 min prior to practice on the water (matched for training volume) 3 days per week...
December 2017: Sports Medicine—Open
https://www.readbyqxmd.com/read/28149381/comparison-between-two-types-of-anaerobic-speed-endurance-training-in-competitive-soccer-players
#11
Magni Mohr, Peter Krustrup
The purpose of the present study was to examine the effects of additional in-season speed endurance production versus speed endurance maintenance training regimes on performance in competitive male soccer players. In a randomised controlled trial 18 male sub-elite players were exposed to additional speed endurance production (SEP) or speed endurance maintenance (SEM) training (two additional sessions/wk for 4 weeks) during the competitive season. Players performed the Yo-Yo intermittent recovery level 2 test (YYIR2) and a repeated sprint test (RST) pre- and post-intervention...
June 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28121838/adopting-systolic-pressure-intervention-trial-sprint-like-office-blood-pressure-measurements-in-clinical-practice
#12
Giuseppe Mancia, Sverre E Kjeldsen
No abstract text is available yet for this article.
March 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28118620/association-of-albuminuria-and-estimated-glomerular-filtration-rate-with-functional-performance-measures-in-older-adults-with-chronic-kidney-disease
#13
Dawn F Wolfgram, Katelyn Garcia, Greg Evans, Sara Zamanian, Rocky Tang, Thomas Wiegmann, Rajeev Sharma, Ruth Campbell, Jeff Whittle
BACKGROUND: Chronic kidney disease (CKD) is increasingly common and disproportionately affects older adults. The contribution of kidney disease to the functional impairment noted in the elderly CKD population is unclear. METHODS: This is a cross-sectional analysis of a hypertensive cohort of people aged ≥75 years from the Systolic Blood Pressure Intervention Trial. We evaluated estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR) as predictors of 3 measures of functional status: EuroQol-5 Dimensional (EQ-5D) score, Falls Efficacy Scale (FES) score, and gait speed...
2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28111758/applying-the-systolic-blood-pressure-intervention-trial-results-to-older-adults
#14
Mark A Supiano, Jeff D Williamson
The Systolic Blood Pressure Intervention Trial (SPRINT; ClinicalTrials.gov, NCT01206062) was stopped early because of significantly lower risk of cardiovascular disease in participants randomized to a systolic blood pressure target of 120 mmHg (intensive) than in those randomized to 140 mmHg (standard). The cardiovascular outcome benefit was also identified in subjects aged 75 and older assigned to the intensive arm-34% lower than in the standard arm-in addition to 33% lower all-cause mortality at 3.14 years of follow-up...
January 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28109971/optimal-systolic-blood-pressure-target-after-sprint-insights-from-a-network-meta-analysis-of-randomized-trials
#15
Sripal Bangalore, Bora Toklu, Eugenia Gianos, Arthur Schwartzbard, Howard Weintraub, Gbenga Ogedegbe, Franz H Messerli
BACKGROUND: The optimal blood pressure (BP) target has been a matter of debate. The recent SPRINT trial showed significant benefits of a BP target of <120 mm Hg albeit with an increase in serious adverse effects related to low BP. METHODS: PUBMED, EMBASE, and CENTRAL were searched for randomized trials comparing treating to different BP targets. Trial arms were grouped into five systolic BP target categories: 1) <160 mm Hg; 2) <150 mm Hg; 3) <140 mm Hg; 4) <130 mm Hg and 5) <120 mm Hg...
January 18, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28106149/blood-pressure-reduction-in-diabetes-lessons-from-accord-sprint-and-empa-reg-outcome
#16
REVIEW
Pantelis A Sarafidis, Antonios A Lazaridis, Gema Ruiz-Hurtado, Luis M Ruilope
In patients with diabetes mellitus, the presence of hypertension substantially increases the risk of cardiovascular events, and reductions in blood pressure (BP) can reduce cardiovascular morbidity and mortality. Following evidence from trials randomizing patients to diastolic BP levels, previous guidelines recommended an office BP target of <130/80 mmHg in individuals with diabetes mellitus. However, the evidence for this systolic BP (SBP) target was derived from observational studies. When the results of the ACCORD-BP study showed that those individuals with diabetes mellitus and a target BP of <120 mmHg had a cardiovascular risk that is similar to those with <140 mmHg, all guidelines returned to a recommended SBP of <140 mmHg...
January 20, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28096758/effects-of-acute-ingestion-of-a-pre-workout-dietary-supplement-with-and-without-p-synephrine-on-resting-energy-expenditure-cognitive-function-and-exercise-performance
#17
Y Peter Jung, Conrad P Earnest, Majid Koozehchian, Elfego Galvan, Ryan Dalton, Dillon Walker, Christopher Rasmussen, Peter S Murano, Mike Greenwood, Richard B Kreider
BACKGROUND: The purpose of this study was to examine the effects of acute ingestion of a pre-workout dietary supplement (PWS) with and without p-synephrine (S) on perceptions of readiness to perform, cognitive function, exercise performance, and markers of safety. METHODS: In a randomized, double-blind, and counterbalanced manner; 25 healthy and recreationally active male and female participants ingested a flavored maltodextrin placebo (PLA), a PWS containing beta-alanine (3 g), creatine nitrate as a salt (2 g), arginine alpha-ketoglutarate (2 g), N-Acetyl-L-Tyrosine (300 mg), caffeine (284 mg), Mucuna pruiriens extract standardized for 15% L-Dopa (15 mg), Vitamin C as Ascorbic Acid (500 mg), niacin (60 mg), folate as folic acid (50 mg), and Vitamin B12 as Methylcobalamin (70 mg) with 2 g of maltodextrin and flavoring; or, the PWS with Citrus aurantium (PWS + S) extract standardized for 30% p-synephrine (20 mg)...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28096757/effects-of-ingesting-a-pre-workout-dietary-supplement-with-and-without-synephrine-for-8%C3%A2-weeks-on-training-adaptations-in-resistance-trained-males
#18
Y Peter Jung, Conrad P Earnest, Majid Koozehchian, Minye Cho, Nick Barringer, Dillon Walker, Christopher Rasmussen, Mike Greenwood, Peter S Murano, Richard B Kreider
BACKGROUND: The purpose of this study was to examine whether ingesting a pre-workout dietary supplement (PWS) with and without synephrine (S) during training affects training responses in resistance-trained males. METHODS: Resistance-trained males (N = 80) were randomly assigned to supplement their diet in a double-blind manner with either a flavored placebo (PLA); a PWS containing beta-alanine (3 g), creatine nitrate as a salt (2 g), arginine alpha-ketoglutarate (2 g), N-Acetyl-L-Tyrosine (300 mg), caffeine (284 mg), Mucuna pruiriens extract standardized for 15% L-Dopa (15 mg), Vitamin C as Ascorbic Acid (500 mg), niacin (60 mg), folate as folic acid (50 mg), and Vitamin B12 as Methylcobalamin (70 mg); or, the PWS supplement with Citrus aurantium extract containing 20 mg of synephrine (PWS + S) once per day for 8-weeks during training...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28090762/use-of-ace-inhibition-and-blood-pressure-management-in-deferring-dialysis-initiation
#19
Lucia Del Vecchio, Ugo Teatini, Francesco Locatelli
Elevated blood pressure is one of the most significant risk factor for the development of chronic kidney disease (CKD); its treatment is a milestone in CKD management. While it is accepted that a stricter blood pressure control is indicated in patients with proteinuria or microalbuminuria, the exact degree of blood pressure reduction to be obtained in CKD patients is still under debate. Following more recent interpretation of old trials, a BP target for < 140/90 mmHg is suggested for non-proteinuric CKD patients...
January 13, 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28079707/effect-of-number-of-sprints-in-a-sit-session-on-change-in-vo2max-a-meta-analysis
#20
Niels Bj Vollaard, Richard S Metcalfe, Sean Williams
PURPOSE: Recent meta-analyses indicate that sprint interval training (SIT) improves cardiorespiratory fitness (V[Combining Dot Above]O2max), but the effects of various training parameters on the magnitude of the improvement remain unknown. The present meta-analysis examined the modifying effect of the number of sprint repetitions in a SIT session on improvements in V[Combining Dot Above]O2max. METHODS: The databases PubMed and Web of Science were searched for original studies that have examined pre- and post-training V[Combining Dot Above]O2max in adults following ≥2 weeks of training consisting of repeated (≥2) Wingate-type cycle sprints, published up to 1 May 2016...
January 10, 2017: Medicine and Science in Sports and Exercise
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