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https://www.readbyqxmd.com/read/29786039/role-of-soluble-st2-levels-and-beta-blockers-dosage-on-cardiovascular-events-of-patients-with-unselected-st-segment-elevation-myocardial-infarction
#1
Wei-Ping Huang, Xuan Zheng, Lei He, Xi Su, Cheng-Wei Liu, Ming-Xiang Wu
Background: Serum soluble ST2 (sST2) levels are elevated early after acute myocardial infarction and are related to adverse left ventricular (LV) remodeling and cardiovascular outcomes in ST-segment elevation myocardial infarction (STEMI). Beta-blockers (BB) have been shown to improve LV remodeling and survival. However, the relationship between sST2, final therapeutic BB dose, and cardiovascular outcomes in STEMI patients remains unknown. Methods: A total of 186 STEMI patients were enrolled at the Wuhan Asia Heart Hospital between January 2015 and June 2015...
June 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29785580/a-comprehensive-review-and-meta-analysis-of-risk-factors-for-statin-induced-myopathy
#2
REVIEW
Khoa A Nguyen, Lang Li, Deshun Lu, Aida Yazdanparast, Lei Wang, Rolf P Kreutz, Elizabeth C Whipple, Titus K Schleyer
PURPOSE: To aid prescribers in assessing a patient's risk for statin-induced myopathy (SIM), we performed a comprehensive review of currently known risk factors and calculated aggregated odds ratios for each risk factor through a meta-analysis. METHODS: This meta-analysis was done through four phases: (1) Identification of the relevant primary literature; (2) abstract screening using inclusion and exclusion criteria; (3) detailed review and data extraction; and (4) synthesis and statistical analysis...
May 22, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29783731/-lactobacillus-plantarum-strain-ln4-attenuates-diet-induced-obesity-insulin-resistance-and-changes-in-hepatic-mrna-levels-associated-with-glucose-and-lipid-metabolism
#3
Eunjung Lee, So-Ra Jung, So-Young Lee, Na-Kyoung Lee, Hyun-Dong Paik, Seong-Il Lim
The prevalence of obesity and associated metabolic disorders, including diabetes and cardiovascular disease, is rapidly becoming a severe global health problem. Recent reports have suggested that the alteration of the gut ecosystem through the consumption of probiotics and fermented foods, such as yogurt and Kimchi, can significantly impact obesity and Type 2 diabetes (T2D)-related biomarkers. In this study, we screened over 400 strains of lactic acid bacteria (LAB) that were isolated from fermented foods to identify potent anti-obesogenic and diabetic probiotics in vitro...
May 19, 2018: Nutrients
https://www.readbyqxmd.com/read/29782392/collagen-biomarkers-predict-new-onset-of-hypertension-in-normotensive-participants-the-multi-ethnic-study-of-atherosclerosis
#4
Daniel A Duprez, Myron D Gross, Joachim H Ix, Jorge R Kizer, Russell P Tracy, Steven Shea, David R Jacobs
OBJECTIVE: Vascular remodeling associated with increased extracellular matrix (ECM) may precede hypertension. Procollagen type III N-terminal propeptide (PIIINP) and collagen type I carboxy-terminal telopeptide (ICTP) reflect collagen turnover and are important in ECM remodeling. PIIINP and ICTP are increased in cardiovascular diseases (CVD). We hypothesized that PIIINP and ICTP among normotensives predict incident hypertension. METHODS: We included 1252 Multi-Ethnic Study of Atherosclerosis participants with mean age 58...
May 17, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29781483/dose-dependent-effects-of-fish-oil-on-cardio-metabolic-biomarkers-in-healthy-middle-aged-and-elderly-chinese-people-a-double-blind-randomized-controlled-trial
#5
Jia Song, Manjiang Hu, Cheng Li, Bo Yang, Qing Ding, Chunhong Wang, Limei Mao
n-3PUFA consumption has been widely accepted as a nutritional strategy for the secondary prevention of cardiovascular events in patients at high risk of cardiovascular disease (CVD), but little is known about the dose-response relationship between dietary n-3PUFA and serum biomarkers associated with cardiovascular health in the general population. The present study involved a 12-week double-blind, randomized controlled trial to explore the effects of fish oil with different doses (0.31, 0.62 and 1.24 g d-1 of EPA and DHA) on serum fatty acids and cardio-metabolic biomarkers including adiponectin, inflammatory markers, lipid profiles and fasting glucose in healthy middle-aged and elderly Chinese people...
May 21, 2018: Food & Function
https://www.readbyqxmd.com/read/29780023/non-coding-rnas-and-exercise-pathophysiological-role-and-clinical-application-in-the-cardiovascular-system
#6
REVIEW
Clarissa P C Gomes, David de Gonzalo-Calvo, Rocio Toro, Tiago Fernandes, Daniel Theisen, Da-Zhi Wang, Yvan Devaux
There is overwhelming evidence that regular exercise training is protective against cardiovascular disease (CVD), the main cause of death worldwide. Despite the benefits of exercise, the intricacies of their underlying molecular mechanisms remain largely unknown. Non-coding RNAs (ncRNAs) have been recognized as a major regulatory network governing gene expression in several physiological processes and appeared as pivotal modulators in a myriad of cardiovascular processes under physiological and pathological conditions...
May 23, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29778925/deep-learning-strategy-for-accurate-carotid-intima-media-thickness-measurement-an-ultrasound-study-on-japanese-diabetic-cohort
#7
Mainak Biswas, Venkatanareshbabu Kuppili, Tadashi Araki, Damodar Reddy Edla, Elisa Cuadrado Godia, Luca Saba, Harman S Suri, Tomaž Omerzu, John R Laird, Narendra N Khanna, Andrew Nicolaides, Jasjit S Suri
MOTIVATION: The carotid intima-media thickness (cIMT) is an important biomarker for cardiovascular diseases and stroke monitoring. This study presents an intelligence-based, novel, robust, and clinically-strong strategy that uses a combination of deep-learning (DL) and machine-learning (ML) paradigms. METHODOLOGY: A two-stage DL-based system (a class of AtheroEdge™ systems) was proposed for cIMT measurements. Stage I consisted of a convolution layer-based encoder for feature extraction and a fully convolutional network-based decoder for image segmentation...
May 12, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29778854/proposed-stages-of-myocardial-phenotype-development-in-fabry-disease
#8
Sabrina Nordin, Rebecca Kozor, Katia Medina-Menacho, Amna Abdel-Gadir, Shanat Baig, Daniel M Sado, Ilaria Lobascio, Elaine Murphy, Robin H Lachmann, Atul Mehta, Nicola C Edwards, Uma Ramaswami, Richard P Steeds, Derralynn Hughes, James C Moon
OBJECTIVES: The authors sought to explore the Fabry myocardium in relation to storage, age, sex, structure, function, electrocardiogram changes, blood biomarkers, and inflammation/fibrosis. BACKGROUND: Fabry disease (FD) is a rare, x-linked lysosomal storage disorder. Mortality is mainly cardiovascular with men exhibiting cardiac symptoms earlier than women. By cardiovascular magnetic resonance, native T1 is low in FD because of sphingolipid accumulation. METHODS: A prospective, observational study of 182 FD (167 adults, 15 children; mean age 42 ± 17 years, 37% male) who underwent cardiovascular magnetic resonance including native T1, late gadolinium enhancement (LGE), and extracellular volume fraction, 12-lead electrocardiogram, and blood biomarkers (troponin and N-terminal pro-brain natriuretic peptide)...
May 11, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29777114/microrna-expression-profile-of-human-advanced-coronary-atherosclerotic-plaques
#9
Mariana S Parahuleva, Christoph Lipps, Behnoush Parviz, Hans Hölschermann, Bernhard Schieffer, Rainer Schulz, Gerhild Euler
MicroRNA (miR) is reported to be involved in vascular inflammation and may represent a novel class of diagnostic biomarkers in cardiovascular disease. We aimed to identify the miR expression profile in human advanced coronary atherosclerotic plaques (CAP) and to connect this expression to the processes in atherosclerosis. Microarray techniques and TaqMan polymerase chain reaction were used to analyse the global expression of 352 miRs in CAP obtained during ACS MULTI-LINK study. 11 miRs were selected on the basis of their implication in atherosclerosis, endothelial activation, and inflammation...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29776990/effect-of-2-psoriasis-treatments-on-vascular-inflammation-and-novel-inflammatory-cardiovascular-biomarkers-a-randomized-placebo-controlled-trial
#10
Nehal N Mehta, Daniel B Shin, Aditya A Joshi, Amit K Dey, April W Armstrong, Kristina Callis Duffin, Zelma Chiesa Fuxench, Charlotte L Harrington, Rebecca A Hubbard, Robert E Kalb, Alan Menter, Daniel J Rader, Muredach P Reilly, Eric L Simpson, Junko Takeshita, Drew A Torigian, Thomas J Werner, Andrea B Troxel, Stephen K Tyring, Suzette Baez Vanderbeek, Abby S Van Voorhees, Martin P Playford, Mark A Ahlman, Abass Alavi, Joel M Gelfand
BACKGROUND: Psoriasis is a chronic inflammatory disease associated with dyslipidemia, cardiovascular events, and mortality. We aimed to assess and compare the effect of treatment of moderate-to-severe psoriasis with adalimumab or phototherapy on vascular inflammation and cardiovascular biomarkers. METHODS AND RESULTS: Randomized, double-blind, trial of adalimumab, phototherapy, and placebo (1:1:1) for 12 weeks, with crossover to adalimumab for 52 weeks total. Outcomes included vascular inflammation by 18 F-fluorodeoxyglucose positron emission tomography/computed tomography and biomarkers of inflammation, insulin resistance, and lipoproteins...
June 2018: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29776960/effect-of-combined-treatment-with-folic-acid-vitamin-b-6-and-vitamin-b-12-on-plasma-biomarkers-of-inflammation-and-endothelial-dysfunction-in-women
#11
William G Christen, Nancy R Cook, Martin Van Denburgh, Elaine Zaharris, Christine M Albert, JoAnn E Manson
BACKGROUND: The aim of this study was to determine whether reducing plasma homocysteine concentrations with long-term, combined treatment with folic acid, vitamin B6 , and vitamin B12 alters plasma biomarkers of inflammation and endothelial dysfunction in women at increased risk of cardiovascular disease. METHODS AND RESULTS: We conducted a blood substudy of 300 treatment-adherent participants (150 in the active treatment group, 150 in the placebo group) in the WAFACS (Women's Antioxidant and Folic Acid Cardiovascular Study), a randomized, double-blind, placebo-controlled trial testing a daily combination of folic acid (2...
May 18, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29773576/joint-effect-of-carotid-plaque-and-c-reactive-protein-on-first-ever-ischemic-stroke-and-myocardial-infarction
#12
Agnethe Eltoft, Kjell Arne Arntzen, Tom Wilsgaard, John-Bjarne Hansen, Ellisiv B Mathiesen, Stein Harald Johnsen
BACKGROUND: The joint effect of atherosclerosis and CRP (C-reactive protein) on risk of ischemic stroke (IS) and myocardial infarction (MI) has been sparsely studied. The aim of this study was to explore whether CRP mediates the risk of events in subjects with prevalent carotid plaque, examine synergism, and test whether CRP and carotid plaque add to risk prediction beyond traditional risk factors. METHODS AND RESULTS: CRP and carotid total plaque area (TPA) were measured in 10 109 participants in the Tromsø Study from 1994 to 2008...
May 17, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29773500/an-analysis-on-distribution-and-inter-relationships-of-biomarkers-under-rivaroxaban-in-japanese-patients-with-non-valvular-atrial-fibrillation-cvi-aro-1
#13
Shinya Suzuki, Takeshi Yamashita, Hidefumi Kasai, Takayuki Otsuka, Koichi Sagara
Prothrombin time (PT) has been widely used for measuring anticoagulation intensity under rivaroxaban therapy, but precise information has not been well established yet. Consecutive 96 non-valvular atrial fibrillation (NVAF) under rivaroxaban between Jan/June, 2015 were recruited. Serum concentration (SC) and PT with 5 representative reagents available in Japan (Neoplastin Plus®, Thromborel S®, Thrombocheck PT®, Thrombocheck PT Plus®, and Recombiplastin®) at 2-4 hours after (peak) and before intake of rivaroxaban (trough) were measured at outpatient clinic in the cardiovascular institute (CVI ARO study 1)...
March 15, 2018: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29771963/predictive-value-of-long-term-changes-of-growth-differentiation-factor-15-over-a-27-year-period-for-heart-failure-and-death-due-to-coronary-heart-disease
#14
Nina Fluschnik, Francisco Ojeda, Tanja Zeller, Torben Jørgensen, Kari Kuulasmaa, Peter Moritz Becher, Christoph Sinning, Stefan Blankenberg, Dirk Westermann
BACKGROUND: Growth differentiation factor-15 (GDF-15), Cystatin C and C-reactive protein (CRP) have been discussed as biomarkers for prediction of cardiac diseases. The aim of this study was to investigate the predictive value of single and repeated measurements of GDF-15 compared to Cystatin C and CRP for incidence of heart failure (HF) and death due to coronary heart disease (CHD) in the general population. METHODS AND RESULTS: Levels of GDF-15, CRP and Cystatin C were determined in three repeated measurements collected 5 years apart in the DAN-MONICA (Danish-Multinational MONitoring of trends and determinants in Cardiovascular disease) cohort (participants at baseline n = 3785)...
2018: PloS One
https://www.readbyqxmd.com/read/29771383/relationship-of-fibroblast-growth-factor-21-with-kidney-function-and-albuminuria-multi-ethnic-study-of-atherosclerosis
#15
Sahapab Anuwatmatee, Matthew A Allison, Michael G Shlipak, Robyn L McClelland, Holly Kramer, Shudi Tang, Liming Hou, Kerry-Anne Rye, Kwok Leung Ong
Background: Fibroblast growth factor 21 (FGF21) may play a role in the development of chronic kidney disease (CKD). We therefore investigated the relationship of plasma FGF21 levels with kidney function and albuminuria in the Multi-Ethnic Study of Atherosclerosis (MESA). Methods: The analysis included 5724 MESA participants ages 45-84 years between 2000 and 2002, free of clinically apparent cardiovascular disease (CVD). Participants were followed up in person at four additional clinic visits over 10 years...
May 15, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29771268/hiv-disease-is-associated-with-increased-biomarkers-of-endothelial-dysfunction-despite-viral-suppression-on-long-term-antiretroviral-therapy-in-botswana
#16
Mosepele Mosepele, Terence Mohammed, Lucy Mupfumi, Sikhulile Moyo, Kara Bennett, Shahin Lockman, Linda C Hemphill, Virginia A Triant
BACKGROUND: Untreated HIV infection is associated with increased biomarkers of endothelial dysfunction. However, the predictors and degree of endothelial dysfunction among virally suppressed HIV-infected adults on long-term antiretroviral therapy (ART) have not been well studied in sub-Saharan Africa (SSA). METHODS: We enrolled 112 HIV-infected adults with virological suppression on long-term ART and 84 HIV-uninfected controls in Botswana. We measured plasma levels of markers of endothelial injury [soluble vascular adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1) and E-selectin] and plasma levels of biomarkers of inflammation [interleukin 6 (IL-6)] and monocyte activation (sCD163)...
May 14, 2018: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29770745/2706-km-cycling-in-two-weeks-effects-on-cardiac-function-in-six-elderly-male-athletes
#17
Thomas Morville, Mads Rosenkilde, Nick Mattsson, Flemming Dela, Jørn W Helge, Hanne K Rasmusen
INTRODUCTION: Physiological effects of exercise on trained and untrained individuals have been studied extensively. Typically, young or middle-aged individuals are examined before and after short periods of vigorous exertion. METHODS: We studied six elderly male athletes (61±8 years (mean ± SD); baseline VO2 max 48±5 ml·kg-1 · min-1 ) with focus on cardiac function and biomarkers following 14 consecutive days of moderate intensity exercise. Cardiac dimensions, function, biomarkers, and other measures of cardiovascular health were examined at baseline and 2 and 28 h after the last day of cycling a total of 2706 km...
May 17, 2018: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/29769455/tenascin-c-a-potential-biomarker-for-predicting-the-severity-of-coronary-atherosclerosis
#18
Wen Gao, Jian Li, Huanchun Ni, Haiming Shi, Zhiyong Qi, Shouguo Zhu, Chuanming Hao, Qionghong Xie, Xinping Luo, Kun Xie
AIMS: Coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide and one of the greatest threats to public health. Tenascin C (TNC) is an extracellular matrix glycoprotein that is found in low concentrations in normal tissues and is enhanced by a range of cardiovascular pathologies. This study aimed to evaluate the value of TNC in assessing the severity of atherosclerosis measured by the Gensini score. METHODS: A total of 157 patients with chest pains who underwent selective coronary angiography for suspected coronary atherosclerosis were enrolled...
May 17, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29768263/fibrinopeptide-a-induces-expression-of-c-reactive-protein-via-the-ros-erk1-2-p38-nf-%C3%AE%C2%BAb-signal-pathway-in-vascular-smooth-muscle-cells
#19
Shouzhu Xu, Jing Zhao, Juntian Liu, Wei Gou
BACKGROUND/AIMS: Atherosclerosis is a chronic inflammatory disease in the artery walls. Fibrinopeptide A (FPA) is a biomarker of the activation of coagulation system, and a high concentration of FPA in blood occurs in patients with ischemic heart disease etc. However, there exist few studies on the pathological effects of FPA in cardiovascular system. Therefore, the present study examined the effect of FPA on CRP expression in VSMCs and the molecular mechanisms. METHODS: mRNA and protein expression was identified by quantitative real-time PCR and Western blot, respectively...
May 11, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29764762/analysis-of-plasma-albumin-vitamin-d-and-apolipoproteins-a-and-b-as-predictive-coronary-risk-biomarkers-in-the-regicor-study
#20
Gabriel Vázquez-Oliva, Alberto Zamora, Rafel Ramos, Isaac Subirana, María Grau, Irene R Dégano, Daniel Muñoz, Montserrat Fitó, Roberto Elosua, Jaume Marrugat
INTRODUCTION AND OBJECTIVES: New biomarkers could improve the predictive capacity of classic risk functions. The aims of this study were to determine the association between circulating levels of apolipoprotein A1 (apoA1), apolipoprotein B (apoB), albumin, and 25-OH-vitamin D and coronary events and to analyze whether these biomarkers improve the predictive capacity of the Framingham-REGICOR risk function. METHODS: A case-cohort study was designed. From an initial cohort of 5404 individuals aged 35 to 74 years with a 5-year follow-up, all the participants who had a coronary event (n = 117) and a random group of the cohort (subcohort; n = 667) were selected...
May 12, 2018: Revista Española de Cardiología
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