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https://www.readbyqxmd.com/read/28944598/dentition-status-and-frailty-in-community-dwelling-older-adults-a-5-year-prospective-cohort-study
#1
Masanori Iwasaki, Akihiro Yoshihara, Misuzu Sato, Kumiko Minagawa, Mieko Shimada, Mamoru Nishimuta, Toshihiro Ansai, Yutaka Yoshitake, Hideo Miyazaki
AIM: To examine the longitudinal association between dentition status and incidence of frailty in older adults. METHODS: The present prospective cohort study included community-dwelling Japanese adults aged 75 years at baseline (n = 322). Dental examinations, biochemical blood examinations, physical performance and anthropometric measurements, and structured questionnaires were carried out at baseline. The presence of ≥20 teeth with nine or more occluding pairs of teeth was defined as functional dentition...
September 24, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28943673/a-statistical-framework-for-pathway-and-gene-identification-from-integrative-analysis
#2
Quefeng Li, Menggang Yu, Sijian Wang
In the era of big data, integrative analyses that pool data from different sources are now extensively conducted in order to improve performance. Among many interesting applications, genomics research is an area where integrative methods become popular tools to identify prognostic biomarkers for various diseases. In this paper, we propose such a framework for pathway and gene identification. Our method employs a hierarchical decomposition on genes' effects followed by a proper regularization to identify important pathways and genes across multiple studies...
April 2017: Journal of Multivariate Analysis
https://www.readbyqxmd.com/read/28943594/effect-of-rosuvastatin-on-cholesterol-efflux-capacity-and-endothelial-function-in-type-2-diabetes-mellitus-and-dyslipidemia
#3
Kyong Yeun Jung, Kyoung Min Kim, Sun Kyoung Han, Han Mi Yun, Tae Jung Oh, Sung Hee Choi, Kyong Soo Park, Hak Chul Jang, Soo Lim
BACKGROUND: Quality and quantity of high-density lipoprotein cholesterol (HDL-C) may be associated with cardiovascular risk. We investigated the effect of rosuvastatin on cholesterol efflux (CE) for HDL function and vascular health.Methods and Results:We enrolled 30 dyslipidemic patients with type 2 diabetes mellitus and 20 healthy subjects as controls. Vascular health was assessed on flow-medicated dilation (FMD), nitroglycerin-induced dilatation of the brachial artery and carotid artery intima-media thickness (cIMT)...
September 22, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28943342/mechanisms-of-platelet-activation-by-the-pneumococcus-and-the-role-of-platelets-in-community-acquired-pneumonia
#4
REVIEW
Ronald Anderson, Charles Feldman
There is increasing recognition of the involvement of platelets in orchestrating inflammatory responses, driving the activation of neutrophils, monocytes and vascular endothelium, which, if poorly controlled, may lead to microvascular dysfunction. Importantly, hyperreactivity of platelets has been implicated in the pathogenesis of myocardial injury and the associated particularly high prevalence of acute cardiovascular events in patients with severe community-acquired pneumonia (CAP), of which Streptococcus pneumoniae (pneumococcus) is the most commonly encountered aetiologic agent...
September 21, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28942562/abnormal-levels-of-vascular-endothelial-biomarkers-in-schizophrenia
#5
Tanya T Nguyen, Sheena I Dev, Guanqing Chen, Sharon C Liou, Averria Sirkin Martin, Michael R Irwin, Judith E Carroll, Xin Tu, Dilip V Jeste, Lisa T Eyler
Schizophrenia is associated with chronic low-grade inflammation, which has been linked to increased vascular risk and rates of cardiovascular disease. Levels of vascular endothelial growth factor (VEGF), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) have been related to aging and neurodegeneration, but their role in schizophrenia remains uncertain. Using a cross-sectional, case-control design, this study included 99 outpatients with schizophrenia and 99 healthy comparison subjects (HCs)...
September 23, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28942393/prognostic-value-of-galectin-3-in-adults-with-congenital-heart-disease
#6
Vivan J M Baggen, Annemien E van den Bosch, Jannet A Eindhoven, Myrthe E Menting, Maarten Witsenburg, Judith A A E Cuypers, Eric Boersma, Jolien W Roos-Hesselink
OBJECTIVE: Galectin-3 is an emerging biomarker for risk stratification in patients with heart failure. This study aims to investigate the release of galectin-3 and its association with cardiovascular events in patients with adult congenital heart disease (ACHD). METHODS: In this prospective cohort study, 602 consecutive patients with ACHD who routinely visited the outpatient clinic were enrolled between 2011 and 2013. Galectin-3 was measured in thaw serum by batch analysis...
September 23, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28941940/mortality-prediction-in-stable-hemodialysis-patients-is-refined-by-ykl-40-a-40-kda-glycoprotein-associated-with-inflammation
#7
Georg Lorenz, Michael Schmalenberg, Stephan Kemmner, Bernhard Haller, Dominik Steubl, Dang Pham, Anita Schreiegg, Quirin Bachmann, Alina Schmidt, Sandra Haderer, Monika Huber, Susanne Angermann, Roman Günthner, Matthias Braunisch, Christine Hauser, Anna-Lena Reichelt, Julia Matschkal, Yana Suttmann, Philipp Moog, Konrad Stock, Claudius Küchle, Klaus Thürmel, Lutz Renders, Axel Bauer, Marcus Baumann, Uwe Heemann, Peter B Luppa, Christoph Schmaderer
Chronic inflammation contributes to increased mortality in hemodialysis (HD) patients. YKL-40 is a novel marker of inflammation, tissue remodeling, and highly expressed in macrophages inside vascular lesions. Elevated levels of YKL-40 have been reported for HD patients but how it integrates into the proinflammatory mediator network as a predictor of mortality remains elusive. We studied serum YKL-40, Interleukin-6 (IL-6), high-sensitivity C-reactive protein, monocyte chemotactic protein-1 (MCP-1), and interferon-gamma induced protein-10 (IP-10) in 475 chronic hemodialysis patients...
September 20, 2017: Kidney International
https://www.readbyqxmd.com/read/28939957/effect-of-hepatitis-c-treatment-with-ombitasvir-paritaprevir-r%C3%A2-%C3%A2-dasabuvir-on-renal-cardiovascular-and-metabolic-extrahepatic-manifestations-a-post-hoc-analysis-of-phase-3-clinical-trials
#8
Darshan A Mehta, Eric Cohen, Mariem Charafeddine, Daniel E Cohen, Yanjun Bao, Yuri Sanchez Gonzalez, Tram T Tran
INTRODUCTION: We analyzed phase 3 trial data of ombitasvir/paritaprevir/ritonavir and dasabuvir (3D) ± ribavirin (RBV) in genotype 1 chronic hepatitis C patients to investigate the impact of 3D ± RBV on renal, cardiovascular and metabolic extrahepatic manifestations (EHMs), including persistency 52 weeks post treatment and differential impact by EHM disease severity. METHODS: Estimated glomerular filtration rate (eGFR), fasting triglyceride and fasting glucose values from clinical trials were used to assess renal, cardiovascular and metabolic EHMs, respectively...
September 22, 2017: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/28939707/trends-in-use-of-biomarker-protocols-for-the-evaluation-of-possible-myocardial-infarction
#9
Brian J Hachey, Michael C Kontos, L Kristin Newby, Robert H Christenson, W Frank Peacock, Katherine C Brewer, James McCord
BACKGROUND: Various combinations of creatine kinase-MB, myoglobin, and cardiac troponin I or T (cTnI/cTnT) have been used to evaluate patients with suspected acute coronary syndromes. The current recommendation is to use the 99th percentile of cTnI/cTnT as the sole marker for diagnosis of acute myocardial infarction. METHODS AND RESULTS: We retrospectively analyzed cardiac marker protocols collected from 824 US hospitals undergoing Chest Pain Center Accreditation through the Society of Cardiovascular Patient Care from 2009 to 2014...
September 22, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28939213/cytokines-and-microrna-in-coronary-artery-disease
#10
Hamed Mirzaei, Gordon A Ferns, Amir Avan, Majid G Mobarhan
Cardiovascular disease (CVD) is a major health problem globally. The high incidence and case fatality of CVD are, to a large extent, a consequence of its late diagnosis and lack of highly sensitive and specific markers. Only a very small number of biomarkers, such as troponin, detect late disease. There is some evidence of an association and dysregulation between specific cytokines in the pathogenesis of CVD. These molecules are involved in inflammatory and immune mechanisms associated with atherogenesis. Several molecular/cellular pathways that include STAT, MAPK, and SMAD are modulated by cytokines...
2017: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/28937015/chronic-noise-exposure-in-the-spontaneously-hypertensive-rat
#11
Anne T M Konkle, Stephen E Keith, James P McNamee, David Michaud
INTRODUCTION: Epidemiological studies have suggested an association between the relative risk for developing cardiovascular disease (CVD) and long-term exposure to elevated levels of transportation noise. The contention is that this association is largely owing to an increase in stress-related biomarkers that are thought to be associated with CVD. Animal models have demonstrated that acute noise exposure is capable of triggering a stress response; however, similar studies using chronic noise models are less common...
September 2017: Noise & Health
https://www.readbyqxmd.com/read/28936747/exosomes-outlook-for-future-cell-free-cardiovascular-disease-therapy
#12
Bahar Barani, Sheeja Rajasingh, Johnson Rajasingh
Cardiovascular diseases are the number one cause of death globally with an estimated 7.4 million people dying from coronary heart disease. Studies have been conducted to identify the therapeutic utility of exosomes in many diseases, including cardiovascular diseases. It has been demonstrated that exosomes are immune modulators, can be used to treat cardiac ischemic injury, pulmonary hypertension and many other diseases, including cancers. Exosomes can be used as a biomarker for disease and cell-free drug delivery system for targeting the cells...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28936745/circulating-exosomes-in-cardiovascular-diseases
#13
Yihua Bei, Ting Chen, Daniel Dumitru Banciu, Dragos Cretoiu, Junjie Xiao
Circulating exosomes could arrive in distant tissues via blood circulation, thus directly communicating with target cells and rapidly regulating intracellular signalings. Circulating exosomes and exosomal cargos are critically involved in cardiovascular pathophysiology, such as cardiomyocyte hypertrophy, apoptosis, and angiogenesis. Circulating exosomes enriched with various types of biological molecules can be changed not only in the number but also in the composite cargos upon cardiac injury, such as myocardial infarction, myocardial ischemia reperfusion injury, atherosclerosis, hypertension, and sepsis cardiomyopathy, which may further influence cardiomyocyte function and contribute to the pathogenesis of cardiovascular diseases...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28936733/exosomes-based-biomarkers-for-the-prognosis-of-cardiovascular-diseases
#14
Yihua Bei, Pujiao Yu, Dragos Cretoiu, Sanda Maria Cretoiu, Junjie Xiao
Cardiovascular diseases (CVDs) have a high prevalence and annually increasing incidence with high mortality and morbidity. Identification of biomarkers with high sensitivity and specificity for assessing the prognosis of CVDs is necessary for optimizing personalized treatment and reducing mortality. Exosomes have been proved to be accessible in nearly all body fluids and they can reflect disease stage or progression. Here we summarized exosomes-based biomarkers for the prognosis of coronary artery diseases, heart failure, stroke, hypertension, cardiac arrhythmia, cardiomyopathy, valvular heart diseases and pulmonary arterial hypertension...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28936732/exosomes-as-diagnostic-biomarkers-in-cardiovascular-diseases
#15
Felix Jansen, Qian Li
Exosomes play important roles in the development and progression of cardiovascular diseases by modulating intercellular communication. Contents and quantities of exosomes are variable under different pathological cardiovascular conditions. Based on these concepts, exosomes have been proposed as novel diagnostic biomarkers in cardiovascular diseases. However, many issues related with clinically applicable biomarkers remain unresolved. Within this chapter, we discuss the potential value, but also the current challenges using exosome numbers and contents as diagnostic and prognostic biomarker in diverse cardiovascular pathologies...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28936442/cardiotoxicity-of-cancer-chemotherapy-identification-prevention-and-treatment
#16
REVIEW
Diwakar Jain, Tauseef Ahmad, Mitchel Cairo, Wilbert Aronow
Cardiotoxicity is an important complication of several cancer therapeutic agents. Several well established and newer anticancer therapies such as anthracyclines, trastuzumab and other HER2 receptor blockers, antimetabolites, alkylating agents, tyrosine kinase inhibitors (TKIs), angiogenesis inhibitors, and checkpoint inhibitors are associated with significant cardiotoxicity. Cardiovascular imaging employing radionuclide imaging, echocardiography and magnetic resonance imaging are helpful in early detection and prevention of overt heart failure secondary to cardiotoxicity of cancer therapy...
September 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28936436/prognostic-value-of-admission-red-blood-cell-distribution-width-in-acute-pancreatitis-a-systematic-review
#17
REVIEW
Hemant Goyal, Hamza Awad, Zhi-De Hu
BACKGROUND: Red blood cell distribution width (RDW) has been proved to be a strong prognostic marker in various diseases such as cardiovascular diseases, renal failure, viral hepatitis etc. But its prognostic value in acute pancreatitis (AP) remains controversial. The aim of this systematic review is to determine the prognostic value of RDW in AP. METHODS: PubMed, Cochrane, Google scholar, and Web of Science were searched on March 2, 2017 to identify studies that investigated the association between RDW and the prognosis of AP...
September 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28934189/cystatin-c-as-a-predictor-of-cardiovascular-outcomes-in-a-hypertensive-population
#18
R Garcia-Carretero, L Vigil-Medina, O Barquero-Perez, R Goya-Esteban, I Mora-Jimenez, C Soguero-Ruiz, J Ramos-Lopez
Calculating the estimated glomerular filtration rate (eGFR) using creatinine-based equations may underestimate cardiovascular risk. Cystatin C-based eGFR may be a stronger prognostic biomarker than creatinine-based eGFR when assessing cardiovascular outcomes and mortality. Our aim was to determine whether levels of serum cystatin C, as an estimator of GFR, had a higher predictive value than creatinine-based eGFR for incident cardiovascular disease among hypertensive patients. We retrospectively analyzed the records of 2016 hypertensive patients from the Hypertension Unit at Mostoles University Hospital between 2006 and 2016...
September 21, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28933970/the-importance-of-calprotectin-levels-in-the-obstructive-sleep-apnea-syndrome-severity
#19
Mümtaz Taner Torun, Ethem Ünver, Yusuf Yalçın, Lutfi Kanmaz, Ender Seçkin
BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is mostly seen in adult populations. It is known that increased levels of several inflammatory mediators play roles in OSAS and related comorbidities. Calprotectin is an inflammatory mediator that increases in some diseases such as Bechet's syndrome, bowel diseases and cardiovascular and cerebrovascular diseases. AIMS: The purpose of this study was to investigate whether calprotectin can be used as a biomarker in OSAS by determining the relation between the serum calprotectin levels and OSAS severity...
September 21, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28933297/circulating-stem-progenitor-cells-as-prognostic-biomarkers-in-macro-and-microvascular-disease-a-narrative-review-of-prospective-observational-studies
#20
Mauro Rigato, Gian Paolo Fadini
BACKGROUND: Circulating progenitor cells (CPCs) and endothelial progenitor cells (EPCs) are immature cells involved in vascular repair and related to many aspects of macro and microvascular disease. OBJECTIVE: We aimed to review studies reporting the prognostic role of CPCs/EPCs measurement on development of cardiovascular disease and microangiopathy. METHODS AND RESULTS: We reviewed the English language literature for prospective observational studies reporting the future development of cardiovascular disease or microangiopathy in patients having a baseline determination of CPCs/EPCs...
September 20, 2017: Current Medicinal Chemistry
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