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Neuroendocrinology

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https://www.readbyqxmd.com/read/29156403/the-role-of-trauma-in-the-hormonal-interplay-of-cortisol-testosterone-and-oxytocin-in-adolescent-aggression
#1
REVIEW
Iro Fragkaki, Maaike Cima, Isabela Granic
Although numerous studies have examined the neuroendocrinology of aggression, the findings are mixed and focused on cortisol and testosterone. We argue that past findings remain inconclusive partly because the key roles of oxytocin and trauma have not been systematically integrated yet. Oxytocin is associated with social behavior and interacts with cortisol and testosterone, whereas trauma is a crucial risk factor of aggression that strongly affects hormonal activity. In this review, we investigate the role of trauma in the hormonal interplay of cortisol, testosterone, and oxytocin in aggression during adolescence...
November 12, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29151262/the-founding-fathers-of-the-international-neuroendocrine-society-ins
#2
EDITORIAL
Víctor D Ramirez
It seems appropriate in this Special Issue of Journal of Neuroendocrinology, which marks the new Pan American Neuroendocrine Society (PANS), to recognize the first group of international scientists who were linked by their common purpose to promote neuroendocrinology throughout the world. This article is protected by copyright. All rights reserved.
November 19, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29147481/is-precocious-puberty-linked-to-hypothalamic-expression-of-arginine-phenylalanine-amide-related-peptide
#3
REVIEW
Yuanyuan He, Wen Sun, Jian Yu
The up-regulation and down-regulation of gonadotropin-releasing hormone (GnRH) in central precocious puberty is not yet known. However, recent advances in neuroendocrinology have shown the controlling role of arginine-phenylalanine RF-amide-related peptides (RFRPs) on GnRH secretion in different phenomenon of reproduction such as estrus cycle and pregnancy, but the exact role of RFRPs in puberty and its related pathologic condition, precocious puberty, is not clear yet. This paper hypothesizes that RFRP is a regulatory peptide of puberty and might prevent the precocious puberty...
October 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29132949/redefining-neuroendocrinology-epigenetics-of-brain-body-communication-over-the-life-course
#4
REVIEW
Bruce S McEwen
The brain is the central organ of stress and adaptation to stress that perceives and determines what is threatening, as well as the behavioral and physiological responses to the stressor, and it does so somewhat differently in males and females. The expression of steroid hormone receptors throughout the brain has broadened the definition of 'neuroendocrinology' to include the reciprocal communication between the entire brain and body via hormonal and neural pathways. Mediated in part via systemic hormonal influences, the adult and developing brain possess remarkable structural and functional plasticity in response to stress, including neuronal replacement, dendritic remodeling, and synapse turnover...
November 10, 2017: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/29122501/psychoneuroimmunological-approach-to-gastrointestinal-related-pain
#5
REVIEW
Karlo Toljan, Bruce Vrooman
BACKGROUND AND PURPOSE (AIMS): Psychoneuroimmunology is both a theoretical and practical field of medicine in which human biology and psychology are considered an interconnected unity. Through such a framework it is possible to elucidate complex syndromes in gastrointestinal related pain, particularly chronic non-malignant. The aim is to provide insight into pathophysiological mechanisms and suggest treatment modalities according to a comprehensive paradigm. The article also presents novel findings that may guide clinicians to recognize new targets or scientists to find new research topics...
November 6, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29026272/incidence-of-diabetes-mellitus-and-neoplasia-in-japanese-short-statured-children-treated-with-growth-hormone-in-the-genetics-and-neuroendocrinology-of-short-stature-international-study-genesis
#6
Susumu Yokoya, Tomonobu Hasegawa, Keiichi Ozono, Hiroyuki Tanaka, Susumu Kanzaki, Toshiaki Tanaka, Kazuo Chihara, Nan Jia, Christopher J Child, Katsuichiro Ihara, Jumpei Funai, Noriyuki Iwamoto, Yoshiki Seino
The primary goal of the Genetics and Neuroendocrinology of Short Stature International Study (GeNeSIS) was to assess the safety and effectiveness of Humatrope(®), a GH preparation, in the treatment of pediatric patients with short stature. We report our findings in the GH-treated Japanese pediatric population focusing on the incidence of type 2 diabetes (T2D) and occurrence of neoplasms. A total of 2,345 Japanese patients were assessed for safety. During a mean observation period of 3.2 yr, T2D occurred in 3 patients (0...
2017: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/28954011/hypothalamic-transcriptional-expression-of-the-kisspeptin-system-and-sex-steroid-receptors-differs-among-polycystic-ovary-syndrome-rat-models-with-different-endocrine-phenotypes
#7
Rodrigo Rodrigues Marcondes, Kátia Cândido Carvalho, Gisele Giannocco, Daniele Coelho Duarte, Natália Garcia, José Maria Soares-Junior, Ismael Dale Cotrim Guerreiro da Silva, Manuel Maliqueo, Edmund Chada Baracat, Gustavo Arantes Rosa Maciel
OBJECTIVES: Polycystic ovary syndrome is a heterogeneous endocrine disorder that affects reproductive-age women. The mechanisms underlying the endocrine heterogeneity and neuroendocrinology of polycystic ovary syndrome are still unclear. In this study, we investigated the expression of the kisspeptin system and gonadotropin-releasing hormone pulse regulators in the hypothalamus as well as factors related to luteinizing hormone secretion in the pituitary of polycystic ovary syndrome rat models induced by testosterone or estradiol...
August 2017: Clinics
https://www.readbyqxmd.com/read/28933061/neuroendocrinology-of-adipose-tissue-and-gut-brain-axis
#8
Paulo Matafome, Hans Eickhoff, Liliana Letra, Raquel Seiça
Food intake and energy expenditure are closely regulated by several mechanisms which involve peripheral organs and nervous system, in order to maintain energy homeostasis.Short-term and long-term signals express the size and composition of ingested nutrients and the amount of body fat, respectively. Ingested nutrients trigger mechanical forces and gastrointestinal peptide secretion which provide signals to the brain through neuronal and endocrine pathways. Pancreatic hormones also play a role in energy balance exerting a short-acting control regulating the start, end, and composition of a meal...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28837830/between-litter-variation-in-developmental-studies-of-hormones-and-behavior-inflated-false-positives-and-diminished-power
#9
REVIEW
Donald R Williams, Rickard Carlsson, Paul-Christian Bürkner
Developmental studies of hormones and behavior often include littermates-rodent siblings that share early-life experiences and genes. Due to between-litter variation (i.e., litter effects), the statistical assumption of independent observations is untenable. In two literatures-natural variation in maternal care and prenatal stress-entire litters are categorized based on maternal behavior or experimental condition. Here, we (1) review both literatures; (2) simulate false positive rates for commonly used statistical methods in each literature; and (3) characterize small sample performance of multilevel models (MLM) and generalized estimating equations (GEE)...
October 2017: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/28812274/oxytocin-and-anxiety-disorders
#10
Michael G Gottschalk, Katharina Domschke
In the present chapter, we review the literature focusing on oxytocin (OT)-centered research in anxiety spectrum conditions, comprising separation anxiety disorder, specific phobias, social anxiety disorder (SAD), panic disorder, generalized anxiety disorder, and anxiety-related endophenotypes (e.g., trust behavior, behavioral inhibition, neuroticism, and state/trait anxiety). OT receptor gene (OXTR) polymorphisms have been implicated in gene-environment interactions with attachment style and childhood maltreatment and to influence clinical outcomes, including SAD intensity and limbic responsiveness...
August 16, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28776585/neuroendocrinology-central-insulin-regulates-eating-behaviour
#11
Claire Greenhill
No abstract text is available yet for this article.
September 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28759937/prevalence-clinical-features-and-natural-history-of-incidental-clinically-non-functioning-pituitary-adenomas
#12
Pedro Iglesias, Karina Arcano, Vanessa Triviño, Paula García-Sancho, Juan José Díez, Carles Villabona, Fernando Cordido
The objective of the study was to assess the prevalence and clinical features of incidentally discovered clinically non-functioning pituitary adenoma (CNFPA) and to analyze its natural history. A multicenter retrospective study in patients diagnosed with incidental CNFPA periodically followed-up in 3 specialized neuroendocrinology units from 1992 to 2015 was performed. Out of a total of 189 CNFPA patients, 57 cases (30.1%; 29 women; age at diagnosis 55.8±16.7 years) were incidental. Most patients (n=55, 96...
July 31, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28752847/neuroendocrinology-integrated-stress-response-linked-to-tbi
#13
Alan Morris
No abstract text is available yet for this article.
September 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28734903/the-olfactory-bulbectomized-rat-model-is-not-an-appropriate-model-for-studying-depression-based-on-morphological-stereological-studies-of-the-hippocampus
#14
Canan Yurttas, Christoph Schmitz, Mehmet Turgut, Tatyana Strekalova, Harry W M Steinbusch
Bilateral olfactory bulbectomy (OBX) has been used as an animal model for major depression that results in behavioral, neurochemical, and neuroendocrinological changes were reversed by chronic treatment with antidepressants, including fluoxetine. However, both etiological and construct validities are lacking in OBX for rats. In the present study, we investigated the morphological changes in the hippocampi of rats undergoing OBX that were treated with fluoxetine (10mg/kg, p.o. once daily for 4 and 12 weeks) using stereological techniques...
July 20, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28575299/mortality-in-children-receiving-growth-hormone-treatment-of-growth-disorders-data-from-the-genetics-and-neuroendocrinology-of-short-stature-international-study
#15
COMPARATIVE STUDY
Charmian A Quigley, Christopher J Child, Alan G Zimmermann, Ron G Rosenfeld, Leslie L Robison, Werner F Blum
Context: Although pediatric growth hormone (GH) treatment is generally considered safe for approved indications, concerns have been raised regarding potential for increased risk of mortality in adults treated with GH during childhood. Objective: To assess mortality in children receiving GH. Design: Prospective, multinational, observational study. Setting: Eight hundred twenty-seven study sites in 30 countries. Patients: Children with growth disorders...
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28506440/the-wistar-audiogenic-rat-war-strain-and-its-contributions-to-epileptology-and-related-comorbidities-history-and-perspectives
#16
Norberto Garcia-Cairasco, Eduardo H L Umeoka, José A Cortes de Oliveira
In the context of modeling epilepsy and neuropsychiatric comorbidities, we review the Wistar Audiogenic Rat (WAR), first introduced to the neuroscience international community more than 25years ago. The WAR strain is a genetically selected reflex model susceptible to audiogenic seizures (AS), acutely mimicking brainstem-dependent tonic-clonic seizures and chronically (by audiogenic kindling), temporal lobe epilepsy (TLE). Seminal neuroethological, electrophysiological, cellular, and molecular protocols support the WAR strain as a suitable and reliable animal model to study the complexity and emergent functions typical of epileptogenic networks...
June 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28502574/diner-database-for-insect-neuropeptide-research
#17
Joseph G C Yeoh, Aniruddha A Pandit, Meet Zandawala, Dick R Nässel, Shireen-Anne Davies, Julian A T Dow
Neuropeptides are responsible for regulating a variety of functions, including development, metabolism, water and ion homeostasis, and as neuromodulators in circuits of the central nervous system. Numerous neuropeptides have been identified and characterized. However, both discovery and functional characterization of neuropeptides across the massive Class Insecta has been sporadic. To leverage advances in post-genomic technologies for this rapidly growing field, insect neuroendocrinology requires a consolidated, comprehensive and standardised resource for managing neuropeptide information...
July 2017: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28445617/a-new-society-for-the-new-world
#18
EDITORIAL
Mike Lehman
While national and regional neuroendocrine societies have existed for some time in Europe and Asia, the Americas have not had a regional society devoted to neuroendocrinology since the "American Neuroendocrine Society" which was active in the 1990s and 2000s. This article is protected by copyright. All rights reserved.
April 26, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28416458/on-the-origins-of-sex-based-differences-in-respiratory-disorders-lessons-and-hypotheses-from-stress-neuroendocrinology-in-developing-rats
#19
REVIEW
Jean-Philippe Rousseau, Luana Tenorio-Lopes, Cécile Baldy, Tara Adele Janes, Stéphanie Fournier, Richard Kinkead
The environment plays a critical role in shaping development and function of the brain. Stress, especially when experienced early in life, can interfere with these processes. In the context of respiratory control, perinatal stress can therefore alter the ability to achieve the "fine-tuning" necessary for proper detection of chemosensory stimuli and production of an adequate motor (respiratory) command. Depending on the timing, intensity, and duration, the detrimental consequences of perinatal exposure to adverse conditions on the respiratory network become manifest at various life stages and can persist into adulthood...
April 14, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28389053/non-functioning-pituitary-adenoma-underwent-surgery-a-multicenter-retrospective-study-over-the-last-four-decades-1977-2015
#20
Pedro Iglesias, Karina Arcano, Vanessa Triviño, Paula García-Sancho, Juan José Díez, Fernando Cordido, Carles Villabona
OBJECTIVE: To assess clinical features, diagnostic procedures, therapies and outcomes in patients with clinically non-functioning pituitary adenomas (NFPAs) surgically treated over the last four decades. DESIGN AND METHODS: A multicenter retrospective study in NFPA patients periodically followed up in specialized neuroendocrinology units who underwent surgery in the period 1977-2015 was performed. RESULTS: A total of 131 patients were studied [66 women (50...
April 4, 2017: European Journal of Internal Medicine
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