keyword
https://read.qxmd.com/read/38531477/sports-and-immunity-from-the-recreational-to-the-elite-athlete
#1
REVIEW
Richard Baskerville, Linda Castell, Stéphane François Bermon
The pivotal role of the immune system in physical activity is well-established. While interactions are complex, they tend to constitute discrete immune responses. Moderate intensity exercise causes leukocytosis with a mild anti-inflammatory cytokine profile and immunoenhancement. Above a threshold of intensity, lactate-mediated IL-6 release causes a proinflammatory followed by a depressed inflammatory state, which stimulates immune adaptation and longer term cardiometabolic enhancement. Exercise-related immune responses are modulated by sex, age and immune-nutrition...
March 24, 2024: Infectious diseases now
https://read.qxmd.com/read/38531329/treatment-and-long-term-safety-outcomes-of-peptide-receptor-radionuclide-therapy-for-metastatic-neuroendocrine-tumours-an-asian-experience
#2
JOURNAL ARTICLE
Wei Ying Tham, Hian Liang Huang, David Wai Meng Tai, John C Allen, Jacqueline S G Hwang, Lih Ming Loh, Brian K P Goh, Simon Y K Ong, Peng Chin Kek, Damien M Y Tan, David C E Ng, Kelvin S H Loke
Peptide-receptor radionuclide therapy (PRRT) is a targeted molecular therapy used to treat neuroendocrine tumours (NET). It has been shown to be effective and well-tolerated in patients with metastatic neuroendocrine tumours in several centres in United States (US), Europe and Australia. Tolerability and efficacy data emerging from Asian centres remain few. Epidemiological evidence suggests that there are differences in neuroendocrine neoplasms between the population groups. We aim to describe the treatment and safety outcomes of PRRT in the Asian population...
March 26, 2024: Neuroendocrinology
https://read.qxmd.com/read/38531145/dhea-and-response-to-antidepressant-treatment-a-mendelian-randomization-analysis
#3
JOURNAL ARTICLE
L H Souza-Teodoro, N M Davies, H R Warren, L H S G Andrade, L A Carvalho
Treatment response is hard to predict and detailed mechanisms unknown. Lower levels of the dehydroepiandrosterone sulphate (DHEA(S)) - a precursor to testosterone and estrogen - have been associated to depression and to response to antidepressant treatment. Previous studies however may have been ridden by confounding and reverse causation. The aim of this study is to evaluate whether higher levels of DHEA(S) are causally linked to response to antidepressants using mendelian randomization (MR). We performed a Two-sample MR analysis using data the largest publicly available GWAS of DHEA(S) levels (n = 14,846) using eight common genetic variants associated to DHEA(S) (seven single nucleotide polymorphisms and one variant rs2497306) and the largest GWAS of antidepressant response (n = 5218) using various MR methods (IVW, MR Egger, Weighted mean, weighted mode, MR-PRESSO) and single SNP analysis...
February 28, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38522818/reproductive-toxicity-of-cadmium-stress-in-male-animals
#4
REVIEW
Zikun Zhang, Qi Wang, Xiaoge Gao, Xu Tang, Huan Xu, Wenqiang Wang, Xin Lei
Cadmium (Cd) is a common heavy metal pollutant in the environment, and the widespread use of products containing Cd compounds in industry has led to excessive levels in the environment, which enter the animal body through the food chain, thus seriously affecting the reproductive development of animals. Related studies have reported that Cd severely affects spermatogonia development and spermatogenesis in animals. In contrast, the reproductive toxicity of Cd in males and its mechanism of action have not been clarified...
March 22, 2024: Toxicology
https://read.qxmd.com/read/38516965/nk3r-signalling-in-the-posterodorsal-medial-amygdala-is-involved-in-stress-induced-suppression-of-pulsatile-lh-secretion-in-female-mice
#5
JOURNAL ARTICLE
Deyana Ivanova, Margaritis Voliotis, Krasimira Tsaneva-Atanasova, Kevin T O'Byrne, Xiao-Feng Li
Psychosocial stress negatively impacts reproductive function by inhibiting pulsatile luteinizing hormone (LH) secretion. The posterodorsal medial amygdala (MePD) is responsible in part for processing stress and modulating the reproductive axis. Activation of the neurokinin 3 receptor (NK3R) suppresses the gonadotropin-releasing hormone (GnRH) pulse generator, under hypoestrogenic conditions, and NK3R activity in the amygdala has been documented to play a role in stress and anxiety. We investigate whether NK3R activation in the MePD is involved in mediating the inhibitory effect of psychosocial stress on LH pulsatility in ovariectomised female mice...
March 22, 2024: Journal of Neuroendocrinology
https://read.qxmd.com/read/38509751/neuroendocrine-and-cellular-mechanisms-in-stress-resilience-from-hormonal-influence-in-the-cns-to-mitochondrial-dysfunction-and-oxidative-stress
#6
REVIEW
Arghya Bhattacharya, Manas Chakraborty, Ananya Chanda, Taha Alqahtani, Ajoy Kumer, Bikram Dhara, Moitreyee Chattopadhyay
Recent advancements in neuroendocrinology challenge the long-held belief that hormonal effects are confined to perivascular tissues and do not extend to the central nervous system (CNS). This paradigm shift, propelled by groundbreaking research, reveals that synthetic hormones, notably in anti-inflammatory medications, significantly influence steroid psychosis, behavioural, and cognitive impairments, as well as neuropeptide functions. A seminal development in this field occurred in 1968 with McEven's proposal that rodent brains are responsive to glucocorticoids, fundamentally altering the understanding of how anxiety impacts CNS functionality and leading to the identification of glucocorticosteroids and mineralocorticoids as distinct corticotropic receptors...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38499895/neuroendocrine-tumor-of-the-appendix-masquerading-as-acute-appendicitis-with-a-mucocele-on-ct-scan-a-rare-finding
#7
JOURNAL ARTICLE
Abdullah S Al-Darwish, Waad Rashaid Alsubaie, Waleed AlShammari, Muath AlaSheikh, Muath AlRashed
INTRODUCTION: Neuroendocrine tumors (NETs) of the appendix are rare and are often discovered incidentally during surgery for acute appendicitis or other unrelated conditions (Modlin et al. in Gastroenterology 128:1717-1751, 2005, Alsaad et al. in Oncol Rep 16:1105-1109, 2006, Frilling et al. in Lancet Oncol 15:e8-e21, 2014). These tumors can range from asymptomatic incidental findings to clinically significant tumors with metastases (Alsaad et al. in Oncol Rep 16:1105-1109, 2006, Gomes et al...
March 19, 2024: Surgical Case Reports
https://read.qxmd.com/read/38482748/witnessed-trauma-exposure-induces-fear-in-mice-through-a-reduction-in-endogenous-neurosteroid-synthesis
#8
JOURNAL ARTICLE
Aidan Evans-Strong, Najah Walton, Katrina Blandino, Abigail T C Roper, S Tiffany Donaldson, Mike Lewis, Jamie Maguire
Neurosteroids have been implicated in the pathophysiology of post-traumatic stress disorder (PTSD). Allopregnanolone is reduced in subsets of individuals with PTSD and has been explored as a novel treatment strategy. Both direct trauma exposure and witnessed trauma are risk factors for PTSD; however, the role of neurosteroids in the behavioral outcomes of these unique experiences has not been explored. Here, we investigate whether observational fear is associated with a reduced capacity for endogenous neurosteroidogenesis and the relationship with behavioral outcomes...
March 14, 2024: Journal of Neuroendocrinology
https://read.qxmd.com/read/38482488/the-psychoneuroimmunological-model-of-moral-distress-and-health-in-healthcare-workers-toward-individual-and-system-level-solutions
#9
REVIEW
Annina Seiler, Aimee Milliken, Richard E Leiter, David Blum, George M Slavich
Healthcare is presently experiencing a global workforce crisis, marked by the inability of hospitals to retain qualified healthcare workers. Indeed, poor working conditions and staff shortages have contributed to structural collapse and placed a heavy toll on healthcare workers' (HCWs) well-being, with many suffering from stress, exhaustion, demoralization, and burnout. An additional factor driving qualified HCWs away is the repeated experience of moral distress, or the inability to act according to internally held moral values and perceived ethical obligations due to internal and external constraints...
February 2024: Comprehensive psychoneuroendocrinology
https://read.qxmd.com/read/38482487/fantastic-voyage-chasing-oxytocin-from-the-bedside-to-the-bench-and-back-again
#10
REVIEW
Martha G Welch
This is the story of my 50-year career in medicine and research, and the people who influenced and helped me most along the way. I recount the way in which I became interested in oxytocin early in my career as a child psychiatrist, and how it led me back to Columbia University, my alma mater, to study oxytocin's role in mother-child innate behaviors. I recount how oxytocin/oxytocin receptor signaling was central to my basic and clinical research and present a new theory on mother-infant emotional behaviors that challenges 400 years of brain-centric science...
February 2024: Comprehensive psychoneuroendocrinology
https://read.qxmd.com/read/38479349/a-tale-of-two-males-behavioral-and-neural-mechanisms-of-alternative-reproductive-tactics-in-midshipman-fish
#11
JOURNAL ARTICLE
Andrew H Bass
An amalgam of investigations at the interface of neuroethology and behavioral neuroendocrinology first established the most basic behavioral, neuroanatomical, and neurophysiological characters of vocal-acoustic communication morphs in the plainfin midshipman fish, Porichthys notatus Girard. This foundation has led, in turn, to the repeated demonstration that neuro-behavioral mechanisms driving reproductive-related, vocal-acoustic behaviors can be uncoupled from gonadal state for two adult male phenotypes that follow alternative reproductive tactics (ARTs)...
March 12, 2024: Hormones and Behavior
https://read.qxmd.com/read/38477040/hypoalbuminemia-but-not-derived-neutrophil-to-lymphocyte-ratio-dnlr-predicts-overall-survival-in-neuroendocrine-tumours-undergoing-peptide-receptor-radionuclide-therapy-a-retrospective-cohort-study-of-557-patients
#12
JOURNAL ARTICLE
Dimitrios Papantoniou, Katarzyna Fröss-Baron, Ulrike Garske-Román, Anders Sundin, Espen Thiis-Evensen, Malin Grönberg, Staffan Welin, Eva Tiensuu Janson
Several inflammation scores have shown association with survival outcomes for patients with neuroendocrine tumours (NET) treated with peptide receptor radionuclide therapy (PRRT). However, whether these scores add value to established prognostic factors remains unknown. In this retrospective, cohort study of 557 NET patients undergoing PRRT in a tertiary referral centre from 2005 to 2015, we examined inflammatory markers and scores previously associated with cancer outcomes, using Cox proportional hazard models and Akaike's information criterion...
March 13, 2024: Journal of Neuroendocrinology
https://read.qxmd.com/read/38475897/21-st-annual-enets-conference-13-15-march-2024
#13
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 2024: Journal of Neuroendocrinology
https://read.qxmd.com/read/38471798/neuroendocrine-neoplasms-consensus-on-a-patient-care-pathway
#14
JOURNAL ARTICLE
Jessica Hooper, Nikie Jervis, Lucy Morgan, Vivienne Beckett, Philippa Hand, Kate Higgs, Alia Munir, Jenny Prinn, D Mark Pritchard, Debashis Sarker, Raj Srirajaskanthan, Catherine Bouvier Ellis
People with neuroendocrine neoplasms (NENs) face a multitude of challenges, including delayed diagnosis, low awareness of the cancer among healthcare professionals and limited access to multidisciplinary care and expert centres. We have developed the first patient care pathway for people living with NENs in England to guide disease management and help overcome these barriers. The pathway was developed in two phases. First, a pragmatic review of the literature was conducted, which was used to develop a draft patient care pathway...
March 12, 2024: Journal of Neuroendocrinology
https://read.qxmd.com/read/38471465/heterogeneity-of-multiple-pancreatic-neuroendocrine-tumors-identified-by-68ga-dotanoc-and-68ga-exendin-4-pet-ct-in-a-patient-with-endogenous-hyperinsulinemic-hypoglycemia-and-multiple-endocrine-neoplasia-1
#15
Junyan Xu, Xiaoping Xu, Meng Zhang, Wensheng Liu, Jie Chen, Shaoli Song
Insulinomas are the most frequent functional neuroendocrine tumors of pancreas. In about 10% cases, insulinomas are associated with hereditary syndrome including multiple endocrine neoplasia 1 (MEN1). Herein, we presented a case of 44-year-old female with recurrent hypoglycemia. In December 1998, this patient has undergone resection of two pancreatic lesions due to hypoglycemia and diagnosed as insulinoma. After operation, the symptom of hypoglycemia disappeared. However, from 2021, hypoglycemic symptoms reappeared frequently and even coma...
March 12, 2024: Neuroendocrinology
https://read.qxmd.com/read/38468186/the-olfactory-bulb-a-neuroendocrine-spotlight-on-feeding-and-metabolism
#16
REVIEW
Romana Stark
Olfaction is the most ancient sense and is needed for food-seeking, danger protection, mating and survival. It is often the first sensory modality to perceive changes in the external environment, before sight, taste or sound. Odour molecules activate olfactory sensory neurons that reside on the olfactory epithelium in the nasal cavity, which transmits this odour-specific information to the olfactory bulb (OB), where it is relayed to higher brain regions involved in olfactory perception and behaviour. Besides odour processing, recent studies suggest that the OB extends its function into the regulation of food intake and energy balance...
March 11, 2024: Journal of Neuroendocrinology
https://read.qxmd.com/read/38468159/prognostic-value-of-inflammation-related-biomarkers-in-patients-with-gastroenteropancreatic-neuroendocrine-neoplasms-a-systematic-review-and-meta-analysis
#17
JOURNAL ARTICLE
Ling-Jun Cui, Fu-Huan Yu, Zi-Xuan Cheng, Fei Su, Ying-Ying Chen, Huang-Ying Tan
Hematological indicators of chronic systemic inflammation are significant biomarkers for gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). We performed a systematic review and meta-analysis to assess the impact of certain factors on the overall survival (OS), progression-free survival (PFS), and disease-free survival (DFS) of patients with GEP-NENs. These factors include the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), lymphocyte/monocyte ratio (LMR), and C-reactive protein (CRP) levels...
March 11, 2024: Journal of Neuroendocrinology
https://read.qxmd.com/read/38460211/vitamin-d-and-behavioral-disorders-in-older-adults-results-from-the-clip-study
#18
JOURNAL ARTICLE
Lucie Gilbert, Alexis Bourgeais, Spyridon N Karras, Duygu Gezen-Ak, Erdinç Dursun, Cédric Annweiler
OBJECTIVES: Vitamin D is involved in brain health and function. Our objective was to determine whether vitamin D deficiency was associated with behavioral disorders in geriatric patients. DESIGN: The observational cross-sectional CLIP (Cognition and LIPophilic vitamins) study. The report followed the STROBE statement. SETTING: Geriatric acute care unit in a tertiary university hospital in France for 3 months at the end of winter and beginning of spring...
March 8, 2024: Journal of Nutrition, Health & Aging
https://read.qxmd.com/read/38457123/the-search-for-the-causes-of-common-hyperandrogenism-1965-to-circa-2015
#19
JOURNAL ARTICLE
Robert L Rosenfield
From 1965-2015, immense strides were made into understanding the mechanisms underlying the common androgen excess disorders, premature adrenarche and polycystic ovary syndrome (PCOS). The author reviews the critical discoveries of this era from his perspective investigating these disorders, commencing with his early discoveries of the unique pattern of plasma androgens in premature adrenarche and the elevation of an index of the plasma free testosterone concentration in most hirsute women. The molecular genetic basis, though not the developmental biologic basis, for adrenarche is now known and 11-oxytestosterones shown to be major bioactive adrenal androgens...
March 8, 2024: Endocrine Reviews
https://read.qxmd.com/read/38432216/a-review-of-the-evolving-role-of-radiotherapy-in-the-treatment-of-neuroendocrine-neoplasms
#20
REVIEW
Ling Fung Nelson Yit, Youquan Li
BACKGROUND: Neuroendocrine neoplasms (NENs) are rare tumors that develop from neuroendocrine cells in various parts of the body. The management of this disease poses a significant challenge because of the heterogeneous clinical presentation and varying degrees of aggressiveness. A multidisciplinary approach is often required in complex clinical situations. Radiation therapy (RT) plays a key role in managing NENs in both curative and palliative settings. SUMMARY: In this review, we summarize and discuss recent developments in the field of advanced RT in early-stage, locally advanced, and metastatic NENs...
March 2, 2024: Neuroendocrinology
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