keyword
https://read.qxmd.com/read/38540306/zebrafish-as-a-model-for-cardiovascular-and-metabolic-disease-the-future-of-precision-medicine
#21
REVIEW
Ramcharan Singh Angom, Naga Malleswara Rao Nakka
The zebrafish ( Danio rerio ) has emerged as an appreciated and versatile model organism for studying cardiovascular and metabolic diseases, offering unique advantages for both basic research and drug discovery. The genetic conservation between zebrafish and humans and their high fecundity and transparent embryos allow for efficient large-scale genetic and drug-oriented screening studies. Zebrafish possess a simplified cardiovascular system that shares similarities with mammals, making them particularly suitable for modeling various aspects of heart development, function, and disease...
March 20, 2024: Biomedicines
https://read.qxmd.com/read/38540214/risk-factors-association-with-transcriptional-activity-of-metalloproteinase-9-mmp-9-and-tissue-inhibitor-of-metalloproteinases-1-timp-1-genes-in-patients-with-heart-failure
#22
JOURNAL ARTICLE
Józefa Dąbek, Dariusz Korzeń, Oskar Sierka, Lech Paluszkiewicz, Hendrik Milting, Zbigniew Gąsior
The aim of the study was to assess the occurrence of classic risk factors in the study group of patients with heart failure and to link them with the transcriptional activity of the examined genes: metalloproteinase 9 (MMP-9) and the tissue inhibitor of metalloproteinases 1 (TIMP-1) . A total of 150 (100%) patients qualified for the study, including 80 (53.33%) patients with heart failure in the course of coronary artery disease, 40 (26.67%) with coronary artery disease without heart failure, and 30 (20.00%) in whom the presence of atherosclerotic changes in the coronary arteries was excluded...
March 7, 2024: Biomedicines
https://read.qxmd.com/read/38539864/enhancing-the-bioavailability-and-bioactivity-of-curcumin-for-disease-prevention-and-treatment
#23
REVIEW
Caroline Bertoncini-Silva, Adelina Vlad, Roberta Ricciarelli, Priscila Giacomo Fassini, Vivian Marques Miguel Suen, Jean-Marc Zingg
Curcumin, a natural polyphenolic component from Curcuma longa roots, is the main bioactive component of turmeric spice and has gained increasing interest due to its proposed anti-cancer, anti-obesity, anti-inflammatory, antioxidant, and lipid-lowering effects, in addition to its thermogenic capacity. While intake from dietary sources such as curry may be sufficient to affect the intestinal microbiome and thus may act indirectly, intact curcumin in the body may be too low (<1 microM) and not sufficient to affect signaling and gene expression, as observed in vitro with cultured cells (10-20 microM)...
March 8, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38539860/induction-of-neuroinflammation-and-brain-oxidative-stress-by-brain-derived-extracellular-vesicles-from-hypertensive-rats
#24
JOURNAL ARTICLE
Xinqian Chen, Xin Yan, Leah Gingerich, Qing-Hui Chen, Lanrong Bi, Zhiying Shan
Neuroinflammation and brain oxidative stress are recognized as significant contributors to hypertension including salt sensitive hypertension. Extracellular vesicles (EVs) play an essential role in intercellular communication in various situations, including physiological and pathological ones. Based on this evidence, we hypothesized that EVs derived from the brains of hypertensive rats with salt sensitivity could trigger neuroinflammation and oxidative stress during hypertension development. To test this hypothesis, we compared the impact of EVs isolated from the brains of hypertensive Dahl Salt-Sensitive rats (DSS) and normotensive Sprague Dawley (SD) rats on inflammatory factors and mitochondrial reactive oxygen species (mtROS) production in primary neuronal cultures and brain cardiovascular relevant regions, including the hypothalamic paraventricular nucleus (PVN) and lamina terminalis (LT)...
March 7, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38539233/from-gene-to-mechanics-a-comprehensive-insight-into-the-mechanobiology-of-lmna-mutations-in-cardiomyopathy
#25
REVIEW
R J A Veltrop, M M Kukk, K Topouzidou, L Didden, A Muchir, F G van Steenbeek, L J Schurgers, M Harakalova
Severe cardiac remodeling leading to heart failure in individuals harboring pathogenic LMNA variants, known as cardiolaminopathy, poses a significant clinical challenge. Currently, there is no effective treatment for lamin-related diseases. Exploring the intricate molecular landscape underlying this condition, with a specific focus on abnormal mechanotransduction, will propel our understanding of cardiolaminopathy. The LMNA gene undergoes alternative splicing to create A-type lamins, a part of the intermediate filament protein family...
March 27, 2024: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/38539069/bioinformatics-integration-reveals-key-genes-associated-with-mitophagy-in-myocardial-ischemia-reperfusion-injury
#26
JOURNAL ARTICLE
Zhian Chen, Tianying Liu, Hao Yuan, Han Sun, Sitong Liu, Shuai Zhang, Li Liu, Shuang Jiang, Yong Tang, Zhi Liu
BACKGROUND: Myocardial ischemia is a prevalent cardiovascular disorder associated with significant morbidity and mortality. While prompt restoration of blood flow is essential for improving patient outcomes, the subsequent reperfusion process can result in myocardial ischemia-reperfusion injury (MIRI). Mitophagy, a specialized autophagic mechanism, has consistently been implicated in various cardiovascular disorders. However, the specific connection between ischemia-reperfusion and mitophagy remains elusive...
March 27, 2024: BMC Cardiovascular Disorders
https://read.qxmd.com/read/38539067/upregulation-of-cirp-by-its-agonist-prevents-the-development-of-heart-failure-in-myocardial-infarction-rats
#27
JOURNAL ARTICLE
Jingjing Zhang, Tao Liu, Yanzhao Wei, Jianye Peng, Gaofeng Zeng, Peng Zhong
BACKGROUND: Downregulated expression of cold-inducible RNA binding protein (CIRP), a stress-response protein, has been demonstrated in the hearts of patients with heart failure (HF). However, whether CIRP plays a critical role in the pathogenesis of HF remains unknown. Zr17-2 is a recently identified CIRP agonist, which can enhance the expression of CIRP in hearts. Herein, we evaluated the effects of zr17-2 on the development of HF in a rat model of myocardial infarction (MI). METHODS: Male SD rats were pretreated with CIRP agonist zr17-2 or vehicle saline for 6 consecutive days, followed by MI induction...
March 27, 2024: BMC Cardiovascular Disorders
https://read.qxmd.com/read/38538579/naked-mole-rats-have-distinctive-cardiometabolic-and-genetic-adaptations-to-their-underground-low-oxygen-lifestyles
#28
JOURNAL ARTICLE
Chris G Faulkes, Thomas R Eykyn, Jan Lj Miljkovic, James D Gilbert, Rebecca L Charles, Hiran A Prag, Nikayla Patel, Daniel W Hart, Michael P Murphy, Nigel C Bennett, Dunja Aksentijevic
The naked mole-rat Heterocephalus glaber is a eusocial mammal exhibiting extreme longevity (37-year lifespan), extraordinary resistance to hypoxia and absence of cardiovascular disease. To identify the mechanisms behind these exceptional traits, metabolomics and RNAseq of cardiac tissue from naked mole-rats was compared to other African mole-rat genera (Cape, Cape dune, Common, Natal, Mahali, Highveld and Damaraland mole-rats) and evolutionarily divergent mammals (Hottentot golden mole and C57/BL6 mouse). We identify metabolic and genetic adaptations unique to naked mole-rats including elevated glycogen, thus enabling glycolytic ATP generation during cardiac ischemia...
March 27, 2024: Nature Communications
https://read.qxmd.com/read/38538007/adeno-associated-virus-based-approach-for-genetic-modification-of-cardiac-fibroblasts-in-adult-rat-hearts
#29
JOURNAL ARTICLE
Bridget Nieto, Michael W Cypress, Bong Sook Jhun, Jin O-Uchi
Cardiac fibroblasts (CFs) are an attractive target for reducing pathological cardiac remodeling, and understanding the underlying mechanisms of these processes is the key to develop successful therapies for treating the pressure-overloaded heart. CF-specific knockout (KO) mouse lines with a Cre recombinase under the control of human TCF21 (hTCF21) promoter and/or an adeno-associated virus serotype 9 (AAV9)-hTCF21 system provide a powerful tool for understanding CF biology in vivo. Although a variety of rat disease models are vital for the research of cardiac fibrosis similar to mouse models, there are few rat models that employ cardiac cell-specific conditional gene modification, which has hindered the development and translational relevance of cardiac disease models...
March 2024: Physiological Reports
https://read.qxmd.com/read/38537100/-not-available
#30
JOURNAL ARTICLE
Luis Alfredo Hernández Villarroel, Mercedes De Lera Alfonso
Introducción. El infarto medular es una patología severa e infrecuente, que representa el 1% del total de ictus isquémicos, siendo además una complicación rara de distintos procedimientos quirúrgicos. Es causado por la interrupción aguda del flujo sanguíneo de la médula espinal, manifestándose con déficits neurológicos clínicos relacionados con el territorio vascular afectado. Métodos. Presentamos el caso de un paciente de 80 años, con factores de riesgo cardiovascular, quien presenta en día postquirúrgico 13, tras colocación de endoprótesis vascular por aneurisma toraco-abdominal aparición brusca de paraparesia con progresión a paraplejía e hipoestesia en ambas extremidades inferiores...
March 27, 2024: Revista de la Facultad de Ciencias Médicas
https://read.qxmd.com/read/38535111/rna-binding-proteins-in-cardiomyopathies
#31
REVIEW
De-Li Shi
The post-transcriptional regulation of gene expression plays an important role in heart development and disease. Cardiac-specific alternative splicing, mediated by RNA-binding proteins, orchestrates the isoform switching of proteins that are essential for cardiomyocyte organization and contraction. Dysfunctions of RNA-binding proteins impair heart development and cause the main types of cardiomyopathies, which represent a heterogenous group of abnormalities that severely affect heart structure and function...
March 5, 2024: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38535109/atypical-progeria-primarily-manifesting-as-premature-cardiac-valvular-disease-segregates-with-lmna-gene-variants
#32
Hoi W Wu, Ivo P Van de Peppel, Julie W Rutten, J Wouter Jukema, Emmelien Aten, Ingrid M Jazet, Tamara T Koopmann, Daniela Q C M Barge-Schaapveld, Nina Ajmone Marsan
Mutations in the LMNA -gene can cause a variety of 'laminopathies'. These laminopathies are associated with a range of phenotypes, including disorders affecting the adipose tissue, peripheral nerves, the heart, such as dilated cardiomyopathy and conduction system abnormalities, and less commonly, progeroid disorders. This case series describes two families in which two novel LMNA-gene variants were identified, and who presented with an atypical progeroid phenotype with primarily premature aortic and mitral valve stenosis...
March 5, 2024: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38533976/shared-genetic-features-of-psoriasis-and-myocardial-infarction-insights-from-a-weighted-gene-coexpression-network-analysis
#33
JOURNAL ARTICLE
Qiaoyu Zhou, Ruizheng Shi
BACKGROUND: Increasing evidence suggests a higher propensity for acute myocardial infarction (MI) in patients with psoriasis. However, the shared mechanisms underlying this comorbidity in these patients remain unclear. This study aimed to explore the shared genetic features of psoriasis and MI and to identify potential biomarkers indicating their coexistence. METHODS AND RESULTS: Data sets obtained from the gene expression omnibus were examined using a weighted gene coexpression network analysis approach...
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38533261/potential-pharmacological-mechanisms-of-tanshinone-iia-in-the-treatment-of-human-neuroblastoma-based-on-network-pharmacological-and-molecular-docking-technology
#34
JOURNAL ARTICLE
Ning Tang, Yan Wang, Jiarui Miao, Yang Zhao, Yue Cao, Wentao Sun, Jingke Zhang, Hua Sui, Bing Li
Tanshinone IIA (Tan-IIA) is the main bioactive component of Chinese herbal medicine salvia miltiorrhiza (Danshen). Sodium sulfonate of Tan-IIA is widely used in the treatment of cardiovascular and cerebrovascular diseases. Tan-IIA also has inhibitory effects on tumor cells such as gastric cancer, but its therapeutic effect and mechanism on human neuroblastoma have not been evaluated, so its pharmacological mechanism is systematically evaluated by the combined method of network pharmacology and molecular docking...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38533084/forward-genetic-screen-using-a-gene-breaking-trap-approach-identifies-a-novel-role-of-grin2bb-associated-rna-transcript-grin2bbart-in-zebrafish-heart-function
#35
JOURNAL ARTICLE
Ramcharan Singh Angom, Adita Joshi, Ashok Patowary, Ambily Sivadas, Soundhar Ramasamy, Shamsudheen K V, Kriti Kaushik, Ankit Sabharwal, Mukesh Kumar Lalwani, Subburaj K, Naresh Singh, Vinod Scaria, Sridhar Sivasubbu
LncRNA-based control affects cardiac pathophysiologies like myocardial infarction, coronary artery disease, hypertrophy, and myotonic muscular dystrophy. This study used a gene-break transposon (GBT) to screen zebrafish ( Danio rerio ) for insertional mutagenesis. We identified three insertional mutants where the GBT captured a cardiac gene. One of the adult viable GBT mutants had bradycardia (heart arrhythmia) and enlarged cardiac chambers or hypertrophy; we named it "bigheart." Bigheart mutant insertion maps to grin2bb or N-methyl D-aspartate receptor (NMDAR2B) gene intron 2 in reverse orientation...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38531898/expanding-the-clinical-spectrum-of-biglycan-related-meester-loeys-syndrome
#36
JOURNAL ARTICLE
Josephina A N Meester, Anne Hebert, Maaike Bastiaansen, Laura Rabaut, Jarl Bastianen, Nele Boeckx, Kathryn Ashcroft, Paldeep S Atwal, Antoine Benichou, Clarisse Billon, Jan D Blankensteijn, Paul Brennan, Stephanie A Bucks, Ian M Campbell, Solène Conrad, Stephanie L Curtis, Majed Dasouki, Carolyn L Dent, James Eden, Himanshu Goel, Verity Hartill, Arjan C Houweling, Bertrand Isidor, Nicola Jackson, Pieter Koopman, Anita Korpioja, Minna Kraatari-Tiri, Liina Kuulavainen, Kelvin Lee, Karen J Low, Alan C Lu, Morgan L McManus, Stephen P Oakley, James Oliver, Nicole M Organ, Eline Overwater, Nicole Revencu, Alison H Trainer, Bhavya Trivedi, Claire L S Turner, Rebecca Whittington, Andreas Zankl, Dominica Zentner, Lut Van Laer, Aline Verstraeten, Bart L Loeys
Pathogenic loss-of-function variants in BGN, an X-linked gene encoding biglycan, are associated with Meester-Loeys syndrome (MRLS), a thoracic aortic aneurysm/dissection syndrome. Since the initial publication of five probands in 2017, we have considerably expanded our MRLS cohort to a total of 18 probands (16 males and 2 females). Segregation analyses identified 36 additional BGN variant-harboring family members (9 males and 27 females). The identified BGN variants were shown to lead to loss-of-function by cDNA and Western Blot analyses of skin fibroblasts or were strongly predicted to lead to loss-of-function based on the nature of the variant...
March 26, 2024: NPJ Genomic Medicine
https://read.qxmd.com/read/38531501/effects-of-moderate-ethanol-exposure-on-risk-factors-for-cardiovascular-disease-and-colorectal-cancer-in-adult-wistar-rats
#37
JOURNAL ARTICLE
Anna J Kwon, Lani Morales, Louise Chatagnier, Jacqueline Quigley, Jeremy Pascua, Natalie Pinkowski, Susan M Brasser, Mee Young Hong
While past studies have provided evidence linking excessive alcohol consumption to increased risk for cardiovascular diseases (CVDs) and colorectal cancer (CRC), existing data on the effects of moderate alcohol use on these conditions have produced mixed results. The purpose of this study was to investigate the effects of moderate alcohol consumption on risk factors associated with the development of CVDs and CRC in adult rats. Twenty-four, 14-month-old, non-deprived male Wistar rats were randomly assigned to either an ethanol group, which consisted of voluntary access to a 20% (v/v) ethanol solution on alternate days, or a water control group (n = 12/group) for 13 weeks...
March 24, 2024: Alcohol
https://read.qxmd.com/read/38529605/role-of-abca1-in-atherosclerosis-novel-mutations-and-potential-plant-derived-therapies
#38
JOURNAL ARTICLE
Siarhei A Dabravolski, Nikolay A Orekhov, Victor Y Glanz, Vasily N Sukhorukov, Elizaveta M Pleshko, Alexander N Orekhov
ATP-binding cassette transporter A1 (ABCA1) is one of the key proteins regulating cholesterol homeostasis and playing a crucial role in atherosclerosis development. ABCA1 regulates the rate-limiting step of reverse cholesterol transport, facilitates the efflux of surplus intracellular cholesterol and phospholipids, and suppresses inflammation through several signalling pathways. At the same time, many mutations and Single Nucleotide Polymorphisms (SNPs) have been identified in the ABCA1 gene, which affects its biological function and is associated with several hereditary diseases (such as familial hypo-alpha-lipoproteinaemia and Tangier disease) and increased risk of cardiovascular diseases (CVDs)...
March 25, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38529333/gender-specific-genetic-and-epigenetic-signatures-in-cardiovascular-disease
#39
REVIEW
Justin Bridges, Jose A Ramirez-Guerrero, Manuel Rosa-Garrido
Cardiac sex differences represent a pertinent focus in pursuit of the long-awaited goal of personalized medicine. Despite evident disparities in the onset and progression of cardiac pathology between sexes, historical oversight has led to the neglect of gender-specific considerations in the treatment of patients. This oversight is attributed to a predominant focus on male samples and a lack of sex-based segregation in patient studies. Recognizing these sex differences is not only relevant to the treatment of cisgender individuals; it also holds paramount importance in addressing the healthcare needs of transgender patients, a demographic that is increasingly prominent in contemporary society...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38528392/nanotechnology-in-development-of-next-generation-of-stent-and-related-medical-devices-current-and-future-aspects
#40
REVIEW
Paromita Islam, Sabrina Schaly, Ahmed Kh Abosalha, Jacqueline Boyajian, Rahul Thareja, Waqar Ahmad, Dominique Shum-Tim, Satya Prakash
Coronary stents have saved millions of lives in the last three decades by treating atherosclerosis especially, by preventing plaque protrusion and subsequent aneurysms. They attenuate the vascular SMC proliferation and promote reconstruction of the endothelial bed to ensure superior revascularization. With the evolution of modern stent types, nanotechnology has become an integral part of stent technology. Nanocoating and nanosurface fabrication on metallic and polymeric stents have improved their drug loading capacity as well as other mechanical, physico-chemical, and biological properties...
2024: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
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