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asthma randomized controlled trial

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https://www.readbyqxmd.com/read/28803594/does-adherence-to-the-mediterranean-dietary-pattern-reduce-asthma-symptoms-in-children-a-systematic-review-of-observational-studies
#1
Maria M Papamichael, Catherine Itsiopoulos, Nugroho H Susanto, Bircan Erbas
OBJECTIVE: The purpose of the present systematic review was to synthesize evidence from the literature to assess efficacy of the Mediterranean dietary pattern in childhood asthma. Design/Setting A systematic search of six databases, three clinical trial registries and hand-search of peer-reviewed articles was conducted up to 29 October 2016. Inclusion criteria included exposure to a Mediterranean dietary pattern, measurement of asthma symptoms and study population of children aged <18 years...
August 14, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28799458/effects-of-an-unsupervised-pedometer-based-physical-activity-program-on-daily-steps-of-adults-with-moderate-to-severe-asthma-a-randomized-controlled-trial
#2
Cristina Martins Coelho, Maycon Moura Reboredo, Felipe Martins Valle, Carla Malaguti, Larissa Almeida Campos, Lucas Mendes Nascimento, Erich Vidal Carvalho, Júlio César Abreu Oliveira, Bruno Valle Pinheiro
Supervised exercise has shown benefits for subjects with asthma, but little is known about the effectiveness of unsupervised physical activity on this population. We investigated the effects of a 12-week unsupervised pedometer-based physical activity program on daily steps and on clinical and psychological parameters of adults with asthma. Clinically stable adults with moderate to severe asthma were encouraged to take daily 30-minute walks and were randomized to pedometer and control groups. The pedometer group received pedometers and individualized daily step targets...
August 11, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28793336/a-systematic-review-of-adverse-drug-events-associated-with-administration-of-common-asthma-medications-in-children
#3
James S Leung, David W Johnson, Arissa J Sperou, Jennifer Crotts, Erik Saude, Lisa Hartling, Antonia Stang
OBJECTIVE: To systematically review the literature and determine frequencies of adverse drug events (ADE) associated with pediatric asthma medications. METHODS: Following PRISMA guidelines, we systematically searched six bibliographic databases between January 1991 and January 2017. Study eligibility, data extraction and quality assessment were independently completed and verified by two reviewers. We included randomized control trials (RCT), case-control, cohort, or quasi-experimental studies where the primary objective was identifying ADE in children 1 month- 18 years old exposed to commercial asthma medications...
2017: PloS One
https://www.readbyqxmd.com/read/28783413/fluticasone-furoate-vilanterol-once-daily-improves-night-time-awakenings-in-asthma-patients-with-night-symptoms-post-hoc-analyses-of-three-randomized-controlled-trials
#4
Edward Kerwin, Neil Barnes, Michael Gibbs, David Leather, Richard Forth, Loretta Jacques, Louisa J Yates
Symptoms, including night-time awakenings, affect the quality of life of people with asthma. Fluticasone furoate/vilanterol (FF/VI) reduces exacerbations, improves lung function, and rescue-free and symptom-free 24-hour periods in patients with asthma. These post-hoc analyses compared daytime and night-time symptoms in patients with asthma who received FF/VI, versus FF, fluticasone propionate (FP) or placebo. Daytime and night-time symptoms were collected via electronic daily diary cards in three Phase III randomized studies of once-daily FF/VI in patients with uncontrolled asthma on inhaled corticosteroids (ICS) ±long-acting beta2-agonists (LABA) (n = 609/1039/586)...
August 7, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28771627/treatment-of-preschool-children-presenting-to-the-emergency-department-with-wheeze-with-azithromycin-a-placebo-controlled-randomized-trial
#5
Piush J Mandhane, Patricia Paredes Zambrano de Silbernagel, Yin Nwe Aung, Janie Williamson, Bonita E Lee, Sheldon Spier, Mary Noseworthy, William R Craig, David W Johnson
BACKGROUND: Antibiotics are frequently used to treat wheezing children. Macrolides may be effective in treating bronchiolitis and asthma. METHOD: We completed a prospective, double-blinded, randomized placebo-control trial of azithromycin among pre-school children (12 to 60 months of age) presenting to the emergency department with wheeze. Patients were randomized to receive either five days of azithromycin or placebo. Primary outcome was time to resolution of respiratory symptoms after treatment initiation...
2017: PloS One
https://www.readbyqxmd.com/read/28768531/the-effect-of-glycopyrronium-and-indacaterol-as-monotherapy-and-in-combination-on-the-methacholine-dose-response-curve-of-mild-asthmatics-a-randomized-three-way-crossover-study
#6
Christianne M Blais, Beth E Davis, Donald W Cockcroft
BACKGROUND: Methacholine dose-response curves illustrate pharmacologic bronchoprotection against methacholine-induced airway hyperresponsiveness and can be used to quantitate changes in airway sensitivity (position), reactivity (slope), and maximal responsiveness following drug administration. Our objective was to determine the influence of single-dose glycopyrronium (long-acting muscarinic antagonist) and indacaterol (ultra-long acting β2 agonist), as monotherapy and in combination, on the methacholine dose-response curve of mild asthmatics and to compare these findings with a non-asthmatic control curve...
August 2, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28752776/efficacy-and-safety-of-inhaled-corticosteroids-relative-to-fluticasone-propionate-a-systematic-review-of-randomized-controlled-trials-in-asthma
#7
See-Hwee Yeo, Bhumika Aggarwal, Sumitra Shantakumar, Aruni Mulgirigama, Peter Daley-Yates
Many trials have been published comparing inhaled corticosteroid (ICS) treatments in asthma. However, mixed results necessitate the summarization of available evidence to aid in decision-making. Areas covered: This systematic review evaluated randomized controlled trials (RCTs) that compared the efficacy and safety of inhaled fluticasone propionate (FP) with other ICS including beclomethasone dipropionate (BDP), budesonide (BUD) and ciclesonide (CIC). PubMed was searched and 54 RCTs that fit pre-determined criteria were included...
August 4, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28732834/patient-perceived-acceptability-and-behaviour-change-benefits-of-inhaler-reminders-and-adherence-feedback-a-qualitative-study
#8
Juliet M Foster, Helen K Reddel, Tim Usherwood, Susan M Sawyer, Lorraine Smith
INTRODUCTION: Little is known about patients' perceptions of electronic inhaler reminders, which have emerged in recent years as adherence promotion aids. This study explored asthma patients' attitudes toward the acceptability and utility of inhaler reminders. METHODS: Participants from a 6-month cluster randomized controlled trial who received reminders for missed doses via SmartTrack adherence monitors (Adherium Ltd) were interviewed to explore their perceptions; interviews were audio-recorded, transcribed and analysed thematically...
August 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28732433/the-effect-of-salt-space-on-clinical-findings-and-peak-expiratory-flow-in-children-with-mild-to-moderate-asthma-a-randomized-crossover-trial
#9
Saeideh Mazloomzadeh, Niousha Bakhshi, Akefeh Ahmadiafshar, Mehdi Gholami
The asthma treatment and control might be associated with significant burden on family and community' thus exploring other therapeutic plans could be desirable. The aim of this study was to investigate the effect of salt space on clinical findings and peak expiratory flow rate among children with asthma. In this randomized crossover trial, 34 patients aged 6-14 years old with mild to moderate asthma were selected and randomly divided into two groups. The first group went through a period of salt therapy by staying in the salt room for one hour, three times a week for 3 consecutive weeks and then was under observation for three weeks...
June 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28724883/calcium-prepartions-do-not-inhibit-allergic-reactions-a-randomized-controlled-trial
#10
Klaudia Matysiak, Michał Matuszewski, Wojciech Feleszko
INTRODUCTION    Massive consumption of dietary supplements, including vitamins and minerals, has recently became a serious public issue in Europe. When ingested, they may negatively affect pharmacological activity of various medications, including anti-allergic drugs. Calcium preparations are well-known and commonly used in some European countries as a popular remedy for allergy-related skin reactions, such as itching, erythema and wheals, as well as insect bites. However, their action has not been reliably proven yet...
June 27, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28718981/health-economic-analysis-of-allergen-immunotherapy-ait-for-the-management-of-allergic-rhinitis-asthma-food-allergy-and-venom-allergy-a-systematic-overview
#11
REVIEW
Miqdad Asaria, Sangeeta Dhami, Ronald van Ree, Roy Gerth van Wijk, Antonella Muraro, Graham Roberts, Aziz Sheikh
BACKGROUND: The European Academy of Allergy and Clinical Immunology (EAACI) is developing guidelines for allergen immunotherapy (AIT) for the management of allergic rhinitis, allergic asthma, IgE-mediated food allergy and venom allergy. To inform the development of clinical recommendations, we undertook systematic reviews to critically assess evidence on the effectiveness, safety and cost-effectiveness of AIT for these conditions. This paper focusses on synthesizing data and gaps in the evidence on the cost-effectiveness of AIT for these conditions...
July 18, 2017: Allergy
https://www.readbyqxmd.com/read/28708944/indirect-comparison-of-bronchial-thermoplasty-versus-omalizumab-for-uncontrolled-severe-asthma
#12
Robert M Niven, Michael R Simmonds, Michael J Cangelosi, Dominic P Tilden, Suzanne Cottrell, Narinder S Shargill
OBJECTIVE: Bronchial thermoplasty (BT) as an add-on therapy for uncontrolled severe asthma is an alternative to biologic therapies like omalizumab (OM). We conducted an indirect treatment comparison (ITC) to appraise comparative effectiveness of BT and OM. METHODS: A systematic literature review identified relevant randomized controlled trials. The ITC followed accepted methodology. RESULTS: The ITC comprised a sham-controlled trial of BT (AIR2) and two placebo-controlled trials of OM (INNOVATE; EXTRA)...
July 14, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28705995/reproducibility-of-airway-luminal-size-in-asthma-measured-by-hrct
#13
Robert H Brown, Robert J Henderson, Elizabeth A Sugar, Janet T Holbrook, Robert A Wise
High resolution computed tomography (HRCT) is a well-established imaging technology to measure lung and airway morphology in vivo. However, there is a surprising lack of studies examining HRCT reproducibility. The CPAP trial was a multicenter, randomized, 3-parallel arm, sham-controlled 12 week clinical trial to assess the use of a nocturnal CPAP device on airways reactivity to methacholine. The lack of a treatment effect of CPAP on clinical or HRCT measures provided an opportunity for the current analysis...
July 13, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28704419/a-pilot-feeding-study-for-adults-with-asthma-the-healthy-eating-better-breathing-trial
#14
Emily P Brigham, Elizabeth C Matsui, Lawrence J Appel, Deborah A Bull, Jean Curtin-Brosnan, Shuyan Zhai, Karen White, Jeanne B Charleston, Nadia N Hansel, Gregory B Diette, Meredith C McCormack
RATIONALE: Evidence from observational studies and to a lesser extent clinical trials suggest that a healthy diet may improve symptoms and lung function in patients with asthma. We conducted a pilot study to determine the feasibility of conducting a larger scale dietary trial and to provide preliminary evidence on the impact of a healthy diet on asthma outcomes. METHODS: In a randomized, two period cross-over trial, participants with asthma received a 4-week dietary intervention followed by a usual diet (or vice versa), separated by a 4-week washout...
2017: PloS One
https://www.readbyqxmd.com/read/28693976/effectiveness-of-the-spirometry-360%C3%A2-quality-improvement-program-for-improving-asthma-care-a-cluster-randomized-trial
#15
Rita Mangione-Smith, Chuan Zhou, Michael J Corwin, James A Taylor, Fiona Rice, James W Stout
OBJECTIVE: To determine the effectiveness of the Spirometry 360™ distance learning quality improvement (QI) program for enhancing the processes and outcomes of care for children with asthma. METHODS: Cluster randomized controlled trial involving 25 matched pairs of pediatric primary care practices. Practices were recruited from two practice-based research networks: the Slone Center Office-based Research Network at Boston University, Boston, MA and the Puget Sound Pediatric Research Network in Seattle, WA...
July 7, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28692145/efficacy-and-safety-of-tiotropium-in-school-age-children-with-moderate-to-severe-symptomatic-asthma-a-systematic-review
#16
Gustavo J Rodrigo, Hugo Neffen
BACKGROUND: Recently published data support the benefits and safety of the once-daily (OD) long-acting anticholinergic tiotropium bromide bronchodilator for the treatment of uncontrolled moderate to severe asthma in adults and adolescents. However, its role for the treatment of school-age asthmatics has not yet been clearly defined. The aim of this systematic review was to assess the efficacy and safety of tiotropium Respimat(®) in children aged 6-11 years with moderate to severe symptomatic asthma...
July 10, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28689843/nonpharmacologic-therapy-for-severe-persistent-asthma
#17
Chase Hall, Linda Nici, Shweta Sood, Richard ZuWallack, Mario Castro
The treatment of asthma largely depends on guideline-based pharmacologic therapies. However, nonpharmacologic therapies for asthma such as pulmonary rehabilitation, focused breathing techniques, and bronchial thermoplasty have an important, yet underappreciated, role. Structured pulmonary rehabilitation programs can reduce dyspnea and increase cardiopulmonary fitness. The educational component of these programs can ensure that therapies are being used appropriately, increase compliance, and decrease health care utilization...
July 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28687413/effect-of-azithromycin-on-asthma-exacerbations-and-quality-of-life-in-adults-with-persistent-uncontrolled-asthma-amazes-a-randomised-double-blind-placebo-controlled-trial
#18
Peter G Gibson, Ian A Yang, John W Upham, Paul N Reynolds, Sandra Hodge, Alan L James, Christine Jenkins, Matthew J Peters, Guy B Marks, Melissa Baraket, Heather Powell, Steven L Taylor, Lex E X Leong, Geraint B Rogers, Jodie L Simpson
BACKGROUND: Exacerbations of asthma cause a substantial global illness burden. Adults with uncontrolled persistent asthma despite maintenance treatment require additional therapy. Since macrolide antibiotics can be used to treat persistent asthma, we aimed to assess the efficacy and safety of oral azithromycin as add-on therapy in patients with uncontrolled persistent asthma on medium-to-high dose inhaled corticosteroids plus a long-acting bronchodilator. METHODS: We did a randomised, double-blind, placebo controlled parallel group trial to determine whether oral azithromycin decreases the frequency of asthma exacerbations in adults (≥18 years) with symptomatic asthma despite current use of inhaled corticosteroid and long-acting bronchodilator, and who had no hearing impairment or abnormal prolongation of the corrected QT interval...
July 4, 2017: Lancet
https://www.readbyqxmd.com/read/28683100/correction-a-multifactorial-weight-reduction-programme-for-children-with-overweight-and-asthma-a-randomized-controlled-trial
#19
Maartje Willeboordse, Kim D G van de Kant, Frans E S Tan, Sandra Mulkens, Julia Schellings, Yvonne Crijns, Liesbeth van der Ploeg, Constant P van Schayck, Edward Dompeling
[This corrects the article DOI: 10.1371/journal.pone.0157158.].
2017: PloS One
https://www.readbyqxmd.com/read/28678392/adding-azathioprine-to-remission-induction-glucocorticoids-for-eosinophilic-granulomatosis-with-polyangiitis-microscopic-polyangiitis-or-polyarteritis-nodosa-without-poor-prognosis-factors-a-randomized-controlled-trial
#20
Xavier Puéchal, Christian Pagnoux, Gabriel Baron, Thomas Quémeneur, Antoine Néel, Christian Agard, François Lifermann, Eric Liozon, Marc Ruivard, Pascal Godmer, Nicolas Limal, Arsène Mékinian, Thomas Papo, Anne-Marie Ruppert, Anne Bourgarit, Boris Bienvenu, Loïck Geffray, Jean-Luc Saraux, Elisabeth Diot, Bruno Crestani, Xavier Delbrel, Laurent Sailler, Pascal Cohen, Véronique Le Guern, Benjamin Terrier, Matthieu Groh, Claire Le Jeunne, Luc Mouthon, Philippe Ravaud, Loïc Guillevin
OBJECTIVE: Most patients with nonsevere systemic necrotizing vasculitides (SNVs) achieve remission with glucocorticoids alone but one-third relapse within 2 years. This study aimed to determine whether azathioprine adjunction to glucocorticoids could achieve a higher sustained remission rate of newly diagnosed nonsevere eosinophilic granulomatosis with polyangiitis (EGPA), microscopic polyangiitis (MPA) or polyarteritis nodosa (PAN). METHODS: All patients included in this double-blind trial received glucocorticoids, gradually tapered over 12 months, and were randomized to receive azathioprine or placebo for 12 months, with stratification according to SNV (EGPA or MPA/PAN)...
July 5, 2017: Arthritis & Rheumatology
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