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asthma randomized controlled trial

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https://www.readbyqxmd.com/read/28097361/folic-acid-supplementation-for-the-prevention-of-neural-tube-defects-an-updated-evidence-report-and-systematic-review-for-the-us-preventive-services-task-force
#1
Meera Viswanathan, Katherine A Treiman, Julia Kish-Doto, Jennifer C Middleton, Emmanuel J L Coker-Schwimmer, Wanda K Nicholson
Importance: Neural tube defects are among the most common congenital anomalies in the United States. Periconceptional folic acid supplementation is a primary care-relevant preventive intervention. Objective: To review the evidence on folic acid supplementation for preventing neural tube defects to inform the US Preventive Services Task Force for an updated Recommendation Statement. Data Sources: MEDLINE, Cochrane Library, EMBASE, and trial registries through January 28, 2016, with ongoing surveillance through November 11, 2016; references; experts...
January 10, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28093815/nigella-sativa-supplementation-improves-asthma-control-and-biomarkers-a-randomized-double-blind-placebo-controlled-trial
#2
Abdulrahman Koshak, Li Wei, Emad Koshak, Siraj Wali, Omer Alamoudi, Abdulrahman Demerdash, Majdy Qutub, Peter Natesan Pushparaj, Michael Heinrich
Poor compliance with conventional asthma medications remains a major problem in achieving asthma control. Nigella sativa oil (NSO) is used traditionally for many inflammatory conditions such as asthma. We aimed to investigate the benefits of NSO supplementation on clinical and inflammatory parameters of asthma. NSO capsules 500 mg twice daily for 4 weeks were used as a supplementary treatment in a randomized, double-blind, placebo-controlled trial in asthmatics (clinicaltrials.gov: NCT02407262). The primary outcome was Asthma Control Test score...
January 17, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28076656/combined-inhaled-beta-agonist-and-anticholinergic-agents-for-emergency-management-in-adults-with-asthma
#3
REVIEW
Scott W Kirkland, Christine Vandenberghe, Britt Voaklander, Taylor Nikel, Sandra Campbell, Brian H Rowe
BACKGROUND: Inhaled short-acting anticholinergics (SAAC) and short-acting beta₂-agonists (SABA) are effective therapies for adult patients with acute asthma who present to the emergency department (ED). It is unclear, however, whether the combination of SAAC and SABA treatment is more effective in reducing hospitalisations compared to treatment with SABA alone. OBJECTIVES: To conduct an up-to-date systematic search and meta-analysis on the effectiveness of combined inhaled therapy (SAAC + SABA agents) vs...
January 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28065396/inhaled-corticosteroid-dose-response-in-asthma-should-we-measure-inflammation
#4
William J Anderson, Philip M Short, Sunny Jabbal, Brian J Lipworth
BACKGROUND: Inhaled corticosteroid (ICS) titration in asthma is primarily based on symptoms and pulmonary function. ICSs may not be increased on this basis despite residual airway inflammation. OBJECTIVE: To compare the dose-response relationships of ICSs on measures of pulmonary function, symptoms, and inflammation in patients with persistent asthma. METHODS: We performed a pooled post hoc analysis of 121 patients with mild to moderate asthma from 4 randomized clinical trials that incorporated an ICS dose ramp...
January 3, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28056541/a-randomized-trial-of-user-controlled-text-messaging-to-improve-asthma-outcomes
#5
Maria T Britto, Jennifer M Rohan, Cassandra M Dodds, Terri L Byczkowski
We enrolled 64 patients age 12 to 22 years with a diagnosis of poorly controlled persistent asthma in a 6-month longitudinal crossover study. During the 3 intervention months, participants created personalized text messages to be sent to their phones. Adherence was objectively monitored in 22 of the participants. The adolescent participants gave high ratings on the acceptability of the text messaging system. Asthma control improved from baseline to month 1 regardless of whether teens were in the texting or control group...
January 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28043872/extensively-hydrolysed-casein-formula-containing-l-rhamnosus-gg-reduces-the-occurrence-of-other-allergic-manifestations-in-children-with-cow-s-milk-allergy-3-year-randomized-controlled-trial
#6
Roberto Berni Canani, Margherita Di Costanzo, Giorgio Bedogni, Antonio Amoroso, Linda Cosenza, Carmen Di Scala, Viviana Granata, Rita Nocerino
BACKGROUND: Children with cow's milk allergy (CMA) have an increased risk of developing other allergic manifestations (AMs). OBJECTIVE: We performed a parallel-arm randomized controlled trial (RCT) to test whether the administration of an extensively hydrolysed casein formula (EHCF) containing the probiotic L. rhamnosus GG (LGG) can reduce the occurrence of other AMs in CMA children. METHODS: Children with IgE-mediated CMA were randomly allocated to EHCF or EHCF+LGG groups and followed for 36 months...
December 30, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28042927/obstructive-sleep-apnea-and-asthma
#7
Megat Razeem Abdul Razak, Naricha Chirakalwasan
Both asthma and obstructive sleep apnea (OSA) are common conditions involving the adults and children population, and have significant impact on the healthcare system. For the last few decades a lot of data emerged in terms of the prevalence between asthma and OSA. The prevalence ranges from 38% up to as high as 70%. Based on the current concepts of bidirectional relationship of OSA and asthma, it is sensible to assume that treating one disorder will result in the other's better control and vice versa. This review will look into the pathogenesis of concomitant OSA and asthma and whether the first line OSA therapy will result in better control of asthma in patients with concomitant OSA...
December 2016: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28034579/a-randomized-clinical-trial-of-a-culturally-responsive-intervention-for-african-american-women-with-asthma
#8
Minal R Patel, Peter X K Song, Georgiana Sanders, Belinda Nelson, Elena Kaltsas, Lara J Thomas, Mary R Janevic, Kausar Hafeez, Wen Wang, Margaret Wilkin, Timothy R Johnson, Randall W Brown
BACKGROUND: Few interventions have focused on the difficulties that African American women face when managing asthma. OBJECTIVE: To evaluate a telephone-based self-regulation intervention that emphasized African American women's management of asthma in a series of 6 sessions. METHODS: A total of 422 African American women with persistent asthma were randomly assigned to either an intervention or control group receiving usual care. Behavioral factors, symptoms and asthma control, asthma-related quality of life, and health care use at baseline and 2 years after baseline were assessed...
December 26, 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28031210/randomised-feasibility-study-of-a-novel-experience-based-internet-intervention-to-support-self-management-in-chronic-asthma
#9
Nikki Newhouse, Angela Martin, Sena Jawad, Ly-Mee Yu, Mina Davoudianfar, Louise Locock, Sue Ziebland, John Powell
OBJECTIVE: To determine the feasibility of a randomised controlled trial (RCT) assessing the effects of an experience-based website as a resource for the self-management of chronic asthma. DESIGN AND SETTING: Feasibility, single-blind RCT in 2 regions of England. Randomisation used computer-generated random number sequence in a 1:1 ratio, after baseline data collection, to website access for 2 weeks. PARTICIPANTS: Adults (age ≥18 years), with clinically diagnosed asthma as coded in their primary care electronic record, prescribed inhaled corticosteroids for at least 3 months in the previous year, were recruited from 9 general practices...
December 28, 2016: BMJ Open
https://www.readbyqxmd.com/read/28029926/fish-oil-derived-fatty-acids-in-pregnancy-and-wheeze-and-asthma-in-offspring
#10
RANDOMIZED CONTROLLED TRIAL
Hans Bisgaard, Jakob Stokholm, Bo L Chawes, Nadja H Vissing, Elin Bjarnadóttir, Ann-Marie M Schoos, Helene M Wolsk, Tine M Pedersen, Rebecca K Vinding, Sunna Thorsteinsdóttir, Nilofar V Følsgaard, Nadia R Fink, Jonathan Thorsen, Anders G Pedersen, Johannes Waage, Morten A Rasmussen, Ken D Stark, Sjurdur F Olsen, Klaus Bønnelykke
Background Reduced intake of n-3 long-chain polyunsaturated fatty acids (LCPUFAs) may be a contributing factor to the increasing prevalence of wheezing disorders. We assessed the effect of supplementation with n-3 LCPUFAs in pregnant women on the risk of persistent wheeze and asthma in their offspring. Methods We randomly assigned 736 pregnant women at 24 weeks of gestation to receive 2.4 g of n-3 LCPUFA (fish oil) or placebo (olive oil) per day. Their children formed the Copenhagen Prospective Studies on Asthma in Childhood2010 (COPSAC2010) cohort and were followed prospectively with extensive clinical phenotyping...
29, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/28017399/safety-and-immunogenicity-of-a-recombinant-adenovirus-type-5-vector-based-ebola-vaccine-in-healthy-adults-in-sierra-leone-a-single-centre-randomised-double-blind-placebo-controlled-phase-2-trial
#11
Feng-Cai Zhu, Alie H Wurie, Li-Hua Hou, Qi Liang, Yu-Hua Li, James B W Russell, Shi-Po Wu, Jing-Xin Li, Yue-Mei Hu, Qiang Guo, Wen-Bo Xu, Abdul R Wurie, Wen-Juan Wang, Zhe Zhang, Wen-Jiao Yin, Manal Ghazzawi, Xu Zhang, Lei Duan, Jun-Zhi Wang, Wei Chen
BACKGROUND: A recombinant adenovirus type-5 vector-based vaccine expressing the glycoprotein of Ebola Zaire Makona variant showed good safety and immunogenicity in a phase 1 trial of healthy Chinese adults. We aimed to assess the safety and immunogenicity of this vaccine in healthy adults in Sierra Leone and to determine the optimal dose. METHODS: We did a single-centre, randomised, double-blind, placebo-controlled, phase 2 clinical trial at Sierra Leone-China Friendship Hospital, Freetown, Sierra Leone...
December 22, 2016: Lancet
https://www.readbyqxmd.com/read/28012663/knemometry-is-more-sensitive-to-systemic-effects-of-inhaled-corticosteroids-in-children-with-asthma-than-24-hour-urine-cortisol-excretion
#12
Bo Chawes, Erik Nilsson, Sarah Nørgaard, Anna Dossing, Li Mortensen, Hans Bisgaard
BACKGROUND: Pharmacodynamic assessment of the systemic effect of inhaled corticosteroids (ICSs) is often done by measuring 24-hour urine free cortisol (UFC) excretion. Knemometry assessing short-term lower-leg growth rate (LLGR) is a more rarely used alternative. OBJECTIVE: The primary aim of this study was to compare the sensitivity of LLGR and 24-hour UFC excretion for evaluating systemic exposure to ICSs in prepubertal children with asthma. The secondary aim was to evaluate factors influencing the precision of LLGR calculated by the traditional 1 leg nonparametric method versus a new 2 leg parametric method...
December 15, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27998692/squill-oxymel-a-traditional-formulation-from-drimia-maritima-l-stearn-as-an-add-on-treatment-in-patients-with-moderate-to-severe-persistent-asthma-a-pilot-triple-blind-randomized-clinical-trial
#13
Fatemeh Nejatbakhsh, Hossein Karegar-Borzi, Gholamreza Amin, Alireza Eslaminejad, Mostafa Hosseini, Mahbubeh Bozorgi, Mehrnaz Asadi Gharabaghi
ETHNOPHARMACOLOGICAL RELEVANCE: In Traditional Iranian Medicine (TIM), Squill (Drimia maritima (L.) Stearn) Oxymel was utilized in the treatment of asthma. Squill has been reported to exert anti-inflammatory, anti-oxidant, anti-cholinergic, and mucus secretion modulating effects. OBJECTIVE: This study aimed to make a preliminary evaluation of the efficacy and safety of an add-on Squill Oxymel treatment in patients with moderate to severe persistent asthma. METHODS: In a 6-week, triple-blind, randomized, placebo-controlled trial, 60 patients with stable moderate to severe persistent asthma were randomly allocated to receive either 10ml syrup of Squill Oxymel, simple oxymel, or a placebo 2 times a day, as an add-on to their routine treatment (inhaled corticosteroids and β2 agonists)...
January 20, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27993289/beneficial-effects-of-omalizumab-therapy-in-allergic-bronchopulmonary-aspergillosis-a-synthesis-review-of-published-literature
#14
REVIEW
Jian-Xiong Li, Li-Chao Fan, Man-Hui Li, Wei-Jun Cao, Jin-Fu Xu
Omalizumab, a humanized mAb that binds to IgE, has been an effective therapy for patients with severe allergic asthma; however, there are few clinical trials examining the efficacy of Omalizumab in patients with allergic bronchopulmonary aspergillosis (ABPA) except some case reports. To assess the clinical and immunological effects of Omalizumab in ABPA patients, we made a synthesis review of 102 cases from 30 published literature, analyzed the effects of Omalizumab therapy in ABPA and conducted subgroup analyses to determine factors that influenced the therapy endpoints...
January 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/27979028/long-term-effects-of-a-house-dust-mite-sublingual-immunotherapy-tablet-in-an-environmental-exposure-chamber-trial
#15
Petra Zieglmayer, Hendrik Nolte, Harold S Nelson, David I Bernstein, Amarjot Kaur, Henrik Jacobi, Patrick Lemell, René Schmutz, René Zieglmayer, Friedrich Horak
BACKGROUND: Treatment with SQ house dust mite (HDM) sublingual immunotherapy (SLIT) tablet is effective for HDM respiratory allergic disease, but data on long-term effects are lacking. OBJECTIVE: Post hoc analyses were conducted to determine the long-term effect of SQ HDM SLIT-tablet on nasal, ocular, and cough symptoms 1 year after discontinuation of treatment. METHODS: Study participants underwent environmental exposure chamber (EEC) challenges at baseline and week 24 in a randomized, placebo-controlled, double-blind trial (NCT01644617) during which participants received daily 12 SQ-HDM, 6 SQ-HDM, or placebo for 24 weeks...
December 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27973083/mepolizumab-for-the-treatment-of-chronic-asthma-a-meta-analysis-of-randomized-placebo-controlled-trials
#16
R Kanukula, N Likhar, A Dang
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27965773/treatment-of-asthma-in-young-children-evidence-based-recommendations
#17
REVIEW
Jose A Castro-Rodriguez, Adnan Custovic, Francine M Ducharme
: In the present review, we focus on evidence-based data for the use of inhaled corticosteroids (ICS), leukotriene receptor antagonist (LTRA), long-acting beta2-agonits (LABA) and oral corticosteroids (OCS), with a special emphasis on well-performed randomized clinical trials (RCTs) and meta-analyses of such trials for the chronic management of asthma/wheeze in infants and preschoolers. RESULTS: Seven meta-analyses and 14 RCTs were reviewed. Daily ICS should be the preferred drug for infants/preschoolers with recurrent wheezing, especially in asthmatics...
2016: Asthma research and practice
https://www.readbyqxmd.com/read/27957746/the-impact-of-olodaterol-on-the-risk-of-mortality-and-serious-adverse-events-a-systematic-review-and-meta-analysis
#18
Hyun Woo Lee, Hyung-Jun Kim, Chang-Hoon Lee
AIMS: Olodaterol is a novel inhaled long-acting beta-agonist (LABA) that showed efficacy as a bronchodilator for patients with chronic obstructive pulmonary disease (COPD) and asthma. However, it is unclear whether olodaterol reduces mortality; the safety issues of olodaterol have not been fully evaluated. METHODS: Randomized controlled trials comparing olodaterol with placebo for patients with COPD or asthma, which evaluated mortality or serious adverse events, were included...
December 13, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27941517/effectiveness-of-school-based-family-asthma-educational-programs-in-quality-of-life-and-asthma-exacerbations-in-asthmatic-children-aged-five-to-18-a-systematic-review
#19
Helen Walter, Fatema Sadeque-Iqbal, Rose Ulysse, Doreen Castillo, Aileen Fitzpatrick, Joanne Singleton
BACKGROUND: Asthma is a common, chronic, non-communicable respiratory disease that affects millions of children worldwide. Asthma exacerbations can range from mild to severe and can have an unfavorable impact on the quality of life of children and their caregivers. Asthma exacerbations often result in absenteeism from school or work, activity intolerance and emergency hospital visits. One strategy to address this health issue in an attempt to improve health outcomes is school-based asthma educational programs...
November 2016: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/27933161/parallel-reductions-of-ige-and-exhaled-nitric-oxide-after-optimized-anti-inflammatory-asthma-treatment
#20
Jörgen Syk, Andrei Malinovschi, Magnus P Borres, Anna-Lena Undén, Anna Andreasson, Mats Lekander, Kjell Alving
Immunoglobulin E (IgE) is crucial for the development of airway inflammation in atopic asthma, and inhibition of IgE using monoclonal antibodies is now part of asthma therapy. However, the impact of ordinary anti-inflammatory treatment on IgE is unclear. The aim of this study was to investigate if optimization of treatment with inhaled corticosteroid (ICS) and leukotriene-receptor antagonist (LTRA) according to symptoms or exhaled nitric oxide (FENO) levels over a one-year period affects IgE concentrations...
June 2016: Immunity, Inflammation and Disease
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