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asthma randomized controlled trial

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https://www.readbyqxmd.com/read/29211545/efficacy-and-safety-of-benralizumab-for-eosinophilic-asthma-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#1
Bao-Ping Tian, Gen-Sheng Zhang, Jian Lou, Hong-Bin Zhou, Wei Cui
CONTEXT: Benralizumab is a humanized monoclonal antibody that targets the α chain of the IL-5 receptor (IL-5Rα) and is currently being assessed in clinical trials for asthma control. OBJECTIVE: Our systematic review and meta-analysis intends to evaluate the therapeutic efficacy and safety of benralizumab in patients with eosinophilic asthma. DATA SOURCES AND EXTRACTION: Literature searches of PubMed, Embase, and the Cochrane Library were performed to identify randomized controlled trials of benralizumab and clinic outcomes in asthmatics...
December 6, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29210124/a-novel-herbal-composition-containing-extracts-of-boswellia-serrata-gum-resin-and-aegle-marmelos-fruit-alleviates-symptoms-of-asthma-in-a-placebo-controlled-double-blind-clinical-study
#2
Pothina Yugandhar, Konda Manikyeswara Rao, Krishanu Sengupta
LI13109F is a novel herbal composition containing the extracts of Boswellia serrata gum resin and Aegle marmelos fruit. This composition dampens leukotriene dependent inflammatory reactions via inhibiting 5-lipoxygenase pathway. In a Sephadex LH-20 induced airway inflammation model of Sprague Dawley rats, LI13109F significantly reduced infiltrated granulocyte population in the bronco-alveolar lavage fluid and normalized Th1/Th2 cytokine balance. Further, a 56-day placebo-controlled and randomized double blind study (Clinical Trial Registration No...
December 6, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29207999/corticosteroid-plus-%C3%AE-2-agonist-in-a-single-inhaler-as-reliever-therapy-in-intermittent-and-mild-asthma-a-proof-of-concept-systematic-review-and-meta-analysis
#3
REVIEW
Gang Wang, Xin Zhang, Hong Ping Zhang, Lei Wang, De Ying Kang, Peter J Barnes, Gang Wang
BACKGROUND: Current guidelines recommend a single inhaler maintenance and reliever therapy (SMART) regimen for moderate to severe asthma. However, evidence for the inhaled corticosteroid plus fast-onset-acting β2-agonist (ICS/FABA) as reliever therapy in management of intermittent and mild asthma patients is lacking. OBJECTIVE: To systematically explore efficacy and safety of the proof-of-concept of the ICS plus FABA regimen in a single inhaler as reliever therapy across children and adults with intermittent and mild persistent asthma...
December 6, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29206634/long-term-real-life-safety-of-omalizumab-in-patients-with-severe-uncontrolled-asthma-a-nine-year-study
#4
Danilo Di Bona, Irene Fiorino, Marialuisa Taurino, Flavia Frisenda, Elena Minenna, Carlo Pasculli, Georgios Kourtis, Anna Simona Rucco, Andrea Nico, Marcello Albanesi, Lucia Giliberti, Luciana D'Elia, Maria Filomena Caiaffa, Luigi Macchia
BACKGROUND: Randomized Controlled Trials showed that omalizumab exhibited a good safety and tolerability profile in patients with moderate-to-severe asthma. However, safety data of long-term treatment with omalizumab are scarce. Our aim was to assess the safety of omalizumab in patients under long-term treatment in a real-life setting. METHODS: Difficult-to-control asthmatic patients treated with omalizumab up to 9 years were retrospectively evaluated. Mild to severe adverse events any and reasons for discontinuation were recorded...
September 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29204582/publication-trends-in-obstructive-sleep-apnea-evidence-of-need-for-more-evidence
#5
R Araslanova, J Paradis, B W Rotenberg
Objective: Published research in obstructive sleep apnea (OSA) appears limited despite OSA being a highly prevalent adult and pediatric disease leading to many adverse outcomes if left untreated. We aimed to quantify the deficit in OSA scientific literature in order to provide a novel way of identifying gaps in knowledge and a need for further research inquiry. Methods: This was a Bibliometric analysis study. Using Ovid Medline database we analyzed and compared research output (medical and surgical) between adult OSA and similarly prevalent chronic conditions (Type II diabetes (T2DM), coronary artery disease (CAD) and osteoarthritis (OA)) from December 2016 up to fifty years prior...
June 2017: World Journal of Otorhinolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29203147/interrelation-of-periodontal-parameters-between-asthmatics-and-nonasthmatics-subjects-a-systematic-review-and-meta-analysis
#6
REVIEW
Vivian Mendes, Gustavo Oliveira Dos Santos, Vittorio Moraschini
BACKGROUND: The aim of this systematic review (SR) is to evaluate the association between asthma and periodontal parameters. METHODS: An electronic search without date or language restrictions ​​was carried out in MEDLINE, Cochrane, Web of Science, and LILACS until May 2017. In addition, manual search and in the grey literature were also conducted. The search process, data analysis, and quality assessment were performed by two independent reviewing authors. Eligibility criteria included prospective and retrospective cohort studies, case-controls, and randomized clinical trials...
December 1, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29193478/possible-therapeutic-effect-of-carvacrol-on-asthmatic-patients-a-randomized-double-blind-placebo-controlled-phase-ii-clinical-trial
#7
Azam Alavinezhad, Mohammad Reza Khazdair, Mohammad Hossein Boskabady
The relaxant effects of carvacrol, a phenolic monoterpene, on tracheal smooth muscle and its preventive effect on asthmatic animals were reported. The effect of carvacrol in asthmatic patients was examined in the placebo group (Group P, n = 11) receiving placebo and treatment group (Group C, n = 12), which received carvacrol capsule (1.2 mg/kg/day) for 2 months in a double-blind manner. Pulmonary function tests, respiratory symptoms, hematological indices, and high-sensitivity C-reactive protein (hs-CRP) were measured before, 1 and 2 months after starting treatment...
November 28, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29186364/efficacy-and-safety-of-oseltamivir-in-children-systematic-review-and-individual-patient-data-meta-analysis-of-randomized-controlled-trials
#8
Ryan E Malosh, Emily T Martin, Terho Heikkinen, W Abdullah Brooks, Richard J Whitley, Arnold S Monto
Background: Oseltamivir has been used to treat children with influenza for nearly two decades, with treatment currently approved for infants 2 weeks of age or older, but efficacy and safety remain controversial. Newer randomized placebo controlled trials (RCT), not included in previous meta-analyses, can add to the evidence base. Methods: We conducted a systematic review to identify RCTs of oseltamivir therapy in children. We obtained individual patient data and examined protocol-defined outcomes...
November 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29182437/immunotherapy-for-pet-allergies
#9
Tuomas Virtanen
Allergic diseases compose a serious challenge for modern societies. Their individual, medical and economical burden is large. As humans spend most of their time indoors, exposure to indoor allergens is a significant contributor to the development of allergic sensitization and respiratory allergies, such as allergic rhinoconjunctivitis and asthma. One important source of indoor allergens are pets, in particular cats and dogs. Allergens from these and other mammals spread effectively and they are encountered widely in public places...
November 28, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29173443/omalizumab-treatment-for-allergic-bronchopulmonary-aspergillosis-in-young-patients-with-cystic-fibrosis
#10
Caroline Perisson, Leila Destruys, Dominique Grenet, Laurence Bassinet, Jocelyne Derelle, Isabelle Sermet-Gaudelus, Caroline Thumerelle, Anne Prevotat, Vincent Rosner, Annick Clement, Harriet Corvol
BACKGROUND: Allergic bronchopulmonary aspergillosis (ABPA) is a severe lung disease complication caused by an Aspergillus fumigatus-induced hypersensitivity that affects 2-15% of patients with cystic fibrosis (CF). The mainstay treatment consists of a combination of corticosteroids and antifungals. However, repeated or long-term corticosteroid therapies can lead to serious side effects. The monoclonal anti-IgE antibody, omalizumab, has demonstrated its efficacy in allergic asthma. As ABPA results from a hypersensitivity to a specific allergen, omalizumab might benefit CF patients with ABPA...
December 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29168570/specific-immunotherapy-in-lar-a-randomized-double-blind-placebo-controlled-trial-with-phleum-pratense-subcutaneous-allergen-immunotherapy
#11
Carmen Rondón, Natalia Blanca-López, Paloma Campo, Cristobalina Mayorga, Raquel Jurado-Escobar, Maria J Torres, Gabriela Canto, Miguel Blanca
BACKGROUND: Allergen immunotherapy has been shown to be an effective treatment for local allergic rhinitis (LAR) to house dust mites. Studies with pollen allergen immunotherapy are limited to observational studies. The aim of this study was to evaluate the clinical efficacy and safety of Phleum pratense subcutaneous immunotherapy (Phl-SCIT) in LAR. METHODS: In a randomized double-blind placebo-controlled study, 56 patients with moderate-severe LAR to grass pollen received Phl-SCIT with a depigmented-polymerized pollen vaccine or placebo for the first year, and Phl-SCIT the second one...
November 23, 2017: Allergy
https://www.readbyqxmd.com/read/29168239/evaluation-of-a-diagnostic-therapeutic-educational-pathway-for-asthma-management-in-youth
#12
Sebastiano Guarnaccia, Cristina Quecchia, Andrea Festa, Michele Magoni, Marco Moneda, Valeria Gretter, Carmelo Scarcella, Ada Pluda, Cinzia Gasparotti, Malica Frassine, Luigi Vitale, Emanuele D'Agata, Rosa Maria Limina, Francesco Donato
BACKGROUND: In spite of some evidence for positive effects of patient's education to asthma self-management by randomized clinical trials, there are few studies on the impact of patient' s educational programs in the real world. We aimed to assess the impact of a diagnostic therapeutic educational pathway (DTEP) on asthma control of children and adolescents by comparing frequency of outcomes indicative of asthma control before and after attending the pathway. METHODS: This is a retrospective cohort study including all patients aged 6-11 and 12-17 years who attended the DTEP in 2007-2014...
November 23, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29152777/evidence-synthesis-from-aggregate-recurrent-event-data-for-clinical-trial-design-and-analysis
#13
Björn Holzhauer, Craig Wang, Heinz Schmidli
Information from historical trials is important for the design, interim monitoring, analysis, and interpretation of clinical trials. Meta-analytic models can be used to synthesize the evidence from historical data, which are often only available in aggregate form. We consider evidence synthesis methods for trials with recurrent event endpoints, which are common in many therapeutic areas. Such endpoints are typically analyzed by negative binomial regression. However, the individual patient data necessary to fit such a model are usually unavailable for historical trials reported in the medical literature...
November 20, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29151559/-effects-of-education-about-action-plans-according-to-self-monitoring-on-self-management-adherence-knowledge-symptom-control-and-quality-of-life-among-adult-asthma-patients-a-randomized-controlled-trial
#14
Ja Yun Choi, Young Ran Kweon
PURPOSE: This study was conducted to identify the effects of education regarding action plans according to a self-monitoring program on self-management adherence, knowledge, symptom control, and health-related quality of life (HRQoL) among adults with asthma. METHODS: Thirty-four patients were randomly assigned to the intervention group and thirty-two to the control group in this study. A tailored 50-minute intervention based on the contents of self-monitoring and action plans developed by the National Heart Lung and Blood Institute was provided to the intervention group...
October 2017: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/29149776/effect-of-nebulized-3-hypertonic-saline-with-salbutamol-on-management-of-acute-asthma-in-outpatient-adults-a-double-blind-randomized-clinical-trial-in-emergency-department
#15
Arash Forouzan, Kambiz Masoumi, Ali Delirrooyfard, Ali Asgari Darian, Laaya Mokhtar Gandomani
Asthma is one of the most common disorders of respiratory tract, management of which still remains as a serious health problem. This study aimed to compare the efficacy of 3% hypertonic saline (HS) plus salbutamol with solely salbutamol on management of acute adults' asthma based on peak flow meter findings. In this double-blind randomized clinical trial, 340 adult patients with acute asthma attacks admitted to emergency department of Ahvaz Golestan and Emam hospitals were enrolled during 2014-2015. The patients were allocated randomly to intervention group (nebulized 2...
October 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29144886/comparative-effectiveness-of-proactive-tobacco-treatment-among-smokers-with-and-without-chronic-lower-respiratory-disease
#16
Anne C Melzer, Barbara Clothier, Sandra J Japuntich, Siamak Noorbaloochi, Patrick Hammett, Diana J Burgess, Anne M Joseph, Steven S Fu
RATIONALE: Adults with chronic lower respiratory disease (CLRD) differ in their barriers to smoking cessation, but also suffer from tobacco related health concerns, which may motivate quit attempts. Few studies have examined differences in tobacco treatment response between smokers with and without CLRD. OBJECTIVE: We examined the effectiveness of a proactive outreach program for cessation among smokers with and without CLRD. METHODS: Subgroup analysis of the Veterans VICTORY Over Tobacco Study, a pragmatic randomized controlled trial that demonstrated the effectiveness of proactive outreach and the choice of tobacco treatments compared to usual care...
November 16, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29133220/effects-of-exercise-and-diet-in-nonobese-asthma-patients-a-randomized-controlled-trial
#17
Louise Lindhardt Toennesen, Howraman Meteran, Morten Hostrup, Nina Rica Wium Geiker, Camilla Bjoern Jensen, Celeste Porsbjerg, Arne Astrup, Jens Bangsbo, Debbie Parker, Vibeke Backer
BACKGROUND: Behavioral interventions focusing on exercise and healthy diet improve asthma control in obese patients with asthma, but whether these interventions can lead to improvements in nonobese patients remains unclear. OBJECTIVES: In a randomized, controlled parallel-group design, we studied the effects of an 8-week intervention of either exercise (high-intensity interval training), diet (high protein/low glycemic index), or a combination of the 2, on asthma control and clinical outcomes in nonobese patients with asthma...
November 10, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29131887/effect-of-an-intervention-to-promote-breastfeeding-on-asthma-lung-function-and-atopic-eczema-at-age-16-years-follow-up-of-the-probit-randomized-trial
#18
Carsten Flohr, A John Henderson, Michael S Kramer, Rita Patel, Jennifer Thompson, Sheryl L Rifas-Shiman, Seungmi Yang, Konstantin Vilchuck, Natalia Bogdanovich, Mikhail Hameza, Richard M Martin, Emily Oken
Importance: Atopic diseases, including asthma and atopic eczema, are the most common chronic conditions of childhood. Objective: To investigate whether an intervention to promote prolonged and exclusive breastfeeding protects against asthma, atopic eczema, and low lung function in adolescence. Design, Setting, and Participants: Follow-up of the Promotion of Breastfeeding Intervention Trial (PROBIT), a cluster randomized trial in 30 Belarusian maternity hospitals and affiliated polyclinics; recruitment of 17 046 healthy term infants took place from June 15, 1996, to December 31, 1997...
November 13, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/29124506/heart-rate-variability-biofeedback-does-not-substitute-for-asthma-steroid-controller-medication
#19
Paul M Lehrer, Charles G Irvin, Shou-En Lu, Anthony Scardella, Beatrix Roehmheld-Hamm, Milisyaris Aviles-Velez, Jessica Graves, Evgeny G Vaschillo, Bronya Vaschillo, Flavia Hoyte, Harold Nelson, Frederick S Wamboldt
Despite previous findings of therapeutic effects for heart rate variability biofeedback (HRVB) on asthma, it is not known whether HRVB can substitute either for controller or rescue medication, or whether it affects airway inflammation. Sixty-eight paid volunteer steroid naïve study participants with mild or moderate asthma were given 3 months of HRVB or a comparison condition consisting of EEG alpha biofeedback with relaxing music and relaxed paced breathing (EEG+), in a two-center trial. All participants received a month of intensive asthma education prior to randomization...
November 9, 2017: Applied Psychophysiology and Biofeedback
https://www.readbyqxmd.com/read/29121432/effectiveness-of-alpine-climate-treatment-for-children-with-difficult-to-treat-atopic-dermatitis-results-of-a-pragmatic-randomized-controlled-trial-davos-trial
#20
Karin Fieten, Renske Schappin, Wieneke Zijlstra, Lilian Figee, Jos Beutler, Florine Raymakers, Harmieke van Os-Medendorp, Rebecca Stellato, Maartje Vandewall, Joan Winkelhof, Monica Uniken Venema, Carla Bruijnzeel-Koomen, Lucia Rijssenbeek-Nouwens, Cornelis van der Ent, Els van Hoffen, Yolanda Meijer, Suzanne Pasmans
BACKGROUND: Alpine climate treatment has historically been used in Europe to treat atopic dermatitis (AD), but no randomized trials have been conducted to provide evidence for its effectiveness. OBJECTIVE: To investigate the long-term effectiveness of alpine climate treatment for children with difficult to treat AD. MATERIALS & METHODS: A pragmatic, open, randomized controlled trial was conducted. Children diagnosed with AD that was considered difficult to treat, aged between 8 and 18 years and willing to be treated in Switzerland were randomized to a six week personalized integrative multidisciplinary treatment period in a clinical setting in the alpine climate (Switzerland) or an outpatient setting in moderate maritime climate (Netherlands)...
November 9, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
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