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https://www.readbyqxmd.com/read/28932549/statins-may-be-beneficial-for-patients-with-pulmonary-hypertension-secondary-to-lung-diseases
#1
Ming-Zhou Zhang, De-Hui Qian, Jian-Cheng Xu, Wei Yao, Ye Fan, Chang-Zheng Wang
BACKGROUND: Previous animal studies and clinical trials report inconsistent findings regarding the role of statins in pulmonary hypertension (PH). Systematic reviews have shown no use of statins on pulmonary arterial hypertension (PAH). This is the first meta-analysis of randomized controlled trials (RCTs) determining the clinical impacts of statin therapy on patients with PH secondary to lung diseases. METHODS: Electronic databases and manual bibliographical searches were conducted...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28928110/perceptions-of-patients-with-chronic-obstructive-pulmonary-disease-and-their-physiotherapists-regarding-the-use-of-an-ehealth-intervention
#2
Sigrid Vorrink, Chantal Huisman, Helianthe Kort, Thierry Troosters, Jan-Willem Lammers
BACKGROUND: If eHealth interventions are not used (properly), their potential benefits cannot be fulfilled. User perceptions of eHealth are an important determinant of its successful implementation. This study examined how patients with chronic obstructive pulmonary disease (COPD) and their physiotherapists (PHTs) value an eHealth self-management intervention following a period of use. OBJECTIVE: The study aimed to evaluate the perceptions of COPD patients and their PHTs as eHealth users...
September 19, 2017: JMIR Human Factors
https://www.readbyqxmd.com/read/28925009/efficacy-of-patients-preferred-exercise-modalities-in-chronic-obstructive-pulmonary-disease-a-parallel-group-randomized-clinical-trial
#3
Meng Wu, Lu-Qian Zhou, Shi Li, Su Zhao, Hui-Jun Fan, Jie-Min Sun, Xiao-Nan Li, Jian Luo, An-Qi Wang, Jian-Ping Wu, Xiaoying Li, Jin-Nong Zhang
INTRODUCTION: Physical exercise effectively improves health-related quality of life in patients with chronic obstructive pulmonary disease (COPD). However, application of this medical intervention is problematic, due to poor adherence to the exercise program or unawareness of the significance of this intervention. OBJECTIVE: To determine whether COPD patients who adopted personal-preferred exercise modalities (PPEMs) for daily training would demonstrate sustained benefits due to improved adherence...
September 19, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28894361/effects-of-daily-vitamin-d-supplementation-on-respiratory-muscle-strength-and-physical-performance-in-vitamin-d-deficient-copd-patients-a-pilot-trial
#4
Rachida Rafiq, Hendrik J Prins, Wim G Boersma, Johannes Ma Daniels, Martin den Heijer, Paul Lips, Renate T de Jongh
BACKGROUND: Although vitamin D is well known for its function in calcium homeostasis and bone mineralization, several studies have shown positive effects on muscle strength and physical function. In addition, vitamin D has been associated with pulmonary function and the incidence of airway infections. As vitamin D deficiency is highly prevalent in chronic obstructive pulmonary disease (COPD) patients, supplementation might have a beneficial effect in these patients. OBJECTIVE: To assess the effect of vitamin D supplementation on respiratory muscle strength and physical performance in vitamin D-deficient COPD patients...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28893134/mepolizumab-for-eosinophilic-chronic-obstructive-pulmonary-disease
#5
Ian D Pavord, Pascal Chanez, Gerard J Criner, Huib A M Kerstjens, Stephanie Korn, Njira Lugogo, Jean-Benoit Martinot, Hironori Sagara, Frank C Albers, Eric S Bradford, Stephanie S Harris, Bhabita Mayer, David B Rubin, Steven W Yancey, Frank C Sciurba
Background Patients with chronic obstructive pulmonary disease (COPD) with an eosinophilic phenotype may benefit from treatment with mepolizumab, a monoclonal antibody directed against interleukin-5. Methods We performed two phase 3, randomized, placebo-controlled, double-blind, parallel-group trials comparing mepolizumab (100 mg in METREX, 100 or 300 mg in METREO) with placebo, given as a subcutaneous injection every 4 weeks for 52 weeks in patients with COPD who had a history of moderate or severe exacerbations while taking inhaled glucocorticoid-based triple maintenance therapy...
September 11, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28891198/targeted-medical-nutrition-for-cachexia-in-chronic-obstructive-pulmonary-disease-a-randomized-controlled-trial
#6
Philip C Calder, Alessandro Laviano, Fredrik Lonnqvist, Maurizio Muscaritoli, Maria Öhlander, Annemie Schols
BACKGROUND: Cachectic patients with chronic obstructive pulmonary disease (COPD) may benefit from nutritional support. This double-blind, randomized, controlled trial evaluated the safety and efficacy of targeted medical nutrition (TMN) vs. an isocaloric comparator in pre-cachectic and cachectic patients with COPD. METHODS: Patients aged ≥50 years with moderate-to-severe COPD and involuntary weight loss or low body mass index (16-18 kg/m(2) ) were randomized 1:1 to receive TMN (~230 kcal; 2 g omega-3 fatty acids; 10 μg 25-hydroxy-vitamin D3) or isocaloric comparator twice daily for 12 weeks (ClinicalTrials...
September 10, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28887809/effect-of-comprehensive-therapy-based-on-chinese-medicine-patterns-on-self-efficacy-and-effectiveness-satisfaction-in-chronic-obstructive-pulmonary-disease-patients
#7
Xue-Qing Yu, Ming-Hang Wang, Jian-Sheng Li, Su-Yun Li, Yang Xie, Yun-Ping Bai, Hai-Long Zhang, Fan Cao, Cong-Xia Hou, Li-Jun Ma
OBJECTIVE: To evaluate the effect of comprehensive therapy based on Chinese medicine (CM) patterns on self-efficacy and satisfaction with its effectiveness in patients with chronic obstructive pulmonary disease (COPD). METHODS: A total of 216 patients were randomly divided into the trial group (n =108) and the control group (n =108) based on the stratified and block randomization design. Patients in the trial group were treated with conventional Western medicine combined with Bufei Jianpi Granules (), Bufei Yishen Granules (), and Yiqi Zishen Granules () according to the CM patterns respectively, and patients in the control group were treated with conventional Western medicine...
September 8, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28887069/better-respiratory-education-and-treatment-help-empower-breathe-study-methodology-and-baseline-characteristics-of-a-randomized-controlled-trial-testing-a-transitional-care-program-to-improve-patient-centered-care-delivery-among-chronic-obstructive-pulmonary
#8
H Aboumatar, M Naqibuddin, S Chung, H Adebowale, L Bone, T Brown, L A Cooper, A P Gurses, A Knowlton, D Kurtz, L Piet, N Putcha, C Rand, D Roter, E Shattuck, C Sylvester, A Urteaga-Fuentes, R Wise, J L Wolff, T Yang, J Hibbard, E Howell, M Myers, K Shea, J Sullivan, L Syron, Wang Nae-Yuh, P Pronovost
BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of hospitalizations. Interventional studies focusing on the hospital-to-home transition for COPD patients are few. In the BREATHE (Better Respiratory Education and Treatment Help Empower) study, we developed and tested a patient and family-centered transitional care program that helps prepare hospitalized COPD patients and their family caregivers to manage COPD at home. METHODS: In the study's initial phase, we co-developed the BREATHE transitional care program with COPD patients, family-caregivers, and stakeholders...
September 5, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28877027/tiotropium-in-early-stage-chronic-obstructive-pulmonary-disease
#9
Yumin Zhou, Nan-Shan Zhong, Xiaochen Li, Shuyun Chen, Jinping Zheng, Dongxing Zhao, Weimin Yao, Rongchang Zhi, Liping Wei, Bingwen He, Xiangyan Zhang, Changli Yang, Ying Li, Fenglei Li, Juan Du, Jianping Gui, Bin Hu, Chunxue Bai, Ping Huang, Gang Chen, Yongjian Xu, Changzheng Wang, Biao Liang, Yinhuan Li, Guoping Hu, Hui Tan, Xianwei Ye, Xitao Ma, Yan Chen, Xiwei Hu, Jia Tian, Xiaodan Zhu, Zhe Shi, Xiufang Du, Minjing Li, Shengming Liu, Ronghuan Yu, Jianping Zhao, Qianli Ma, Canmao Xie, Xiongbin Li, Tao Chen, Yingxiang Lin, Lizhen Zeng, Changxiu Ye, Weishu Ye, Xiangwen Luo, Lingshan Zeng, Shuqing Yu, Wei-Jie Guan, Pixin Ran
BACKGROUND: Patients with mild or moderate chronic obstructive pulmonary disease (COPD) rarely receive medications, because they have few symptoms. We hypothesized that long-term use of tiotropium would improve lung function and ameliorate the decline in lung function in patients with mild or moderate COPD. METHODS: In a multicenter, randomized, double-blind, placebo-controlled trial that was conducted in China, we randomly assigned 841 patients with COPD of Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage 1 (mild) or 2 (moderate) severity to receive a once-daily inhaled dose (18 μg) of tiotropium (419 patients) or matching placebo (422) for 2 years...
September 7, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28872442/added-value-of-computer-aided-ct-image-features-for-early-lung-cancer-diagnosis-with-small-pulmonary-nodules-a-matched-case-control-study
#10
Peng Huang, Seyoun Park, Rongkai Yan, Junghoon Lee, Linda C Chu, Cheng T Lin, Amira Hussien, Joshua Rathmell, Brett Thomas, Chen Chen, Russell Hales, David S Ettinger, Malcolm Brock, Ping Hu, Elliot K Fishman, Edward Gabrielson, Stephen Lam
Purpose To test whether computer-aided diagnosis (CAD) approaches can increase the positive predictive value (PPV) and reduce the false-positive rate in lung cancer screening for small nodules compared with human reading by thoracic radiologists. Materials and Methods A matched case-control sample of low-dose computed tomography (CT) studies in 186 participants with 4-20-mm noncalcified lung nodules who underwent biopsy in the National Lung Screening Trial (NLST) was selected. Variables used for matching were age, sex, smoking status, chronic obstructive pulmonary disease status, body mass index, study year of the positive screening test, and screening results...
September 5, 2017: Radiology
https://www.readbyqxmd.com/read/28870157/ten-important-articles-on-noninvasive-ventilation-in-critically-ill-patients-and-insights-for-the-future-a-report-of-expert-opinions
#11
A Cortegiani, V Russotto, M Antonelli, E Azoulay, A Carlucci, G Conti, A Demoule, M Ferrer, N S Hill, S Jaber, P Navalesi, P Pelosi, R Scala, C Gregoretti
BACKGROUND: Noninvasive ventilation is used worldwide in many settings. Its effectiveness has been proven for common clinical conditions in critical care such as cardiogenic pulmonary edema and chronic obstructive pulmonary disease exacerbations. Since the first pioneering studies of noninvasive ventilation in critical care in the late 1980s, thousands of studies and articles have been published on this topic. Interestingly, some aspects remain controversial (e.g. its use in de-novo hypoxemic respiratory failure, role of sedation, self-induced lung injury)...
September 4, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28851462/effects-of-a-brief-pedometer-based-behavioral-intervention-for-individuals-with-copd-during-inpatient-pulmonary-rehabilitation-on-6-week-and-6-month-objectively-measured-physical-activity-study-protocol-for-a-randomized-controlled-trial
#12
Wolfgang Geidl, Jana Semrau, René Streber, Nicola Lehbert, Silke Wingart, Alexander Tallner, Michael Wittmann, Rupert Wagner, Konrad Schultz, Klaus Pfeifer
BACKGROUND: Pulmonary rehabilitation programs often fail to substantially enhance long-term physical activity in patients with chronic obstructive pulmonary disease (COPD). The reasons for successful physical activity changes in patients with COPD are not well understood. The need to better understand the determinants of physical activity in patients with COPD and effective rehabilitation strategies to improve physical activity is evident. METHODS/DESIGN: The STAR study (Stay Active after Rehabilitation) investigates, in a randomized controlled trial, the additional effect of a pedometer-based behavior-change intervention during inpatient pulmonary rehabilitation on objectively measured physical activity 6 weeks and 6 months post rehabilitation...
August 29, 2017: Trials
https://www.readbyqxmd.com/read/28851233/shuttle-walk-tests-in-people-with-copd-who-demonstrate-exercise-induced-oxygen-desaturation-an-analysis-of-test-repeatability-and-cardiorespiratory-responses
#13
Zoe McKeough, Regina Leung, Ji Hui Neo, Sue Jenkins, Anne Holland, Kylie Hill, Norman Morris, Lissa Spencer, Catherine Hill, Annemarie Lee, Helen Seale, Nola Cecins, Christine McDonald, Jennifer Alison
Exercise-induced oxygen desaturation (EID) is prevalent in people with chronic obstructive pulmonary disease (COPD). This article reports a sub-analysis from a randomized controlled trial (RCT) in people with COPD and EID (COPD/EID). The primary aim, in people with COPD/ EID, was to determine the repeatability of the distance and time walked in the incremental shuttle walk test (ISWT) and endurance shuttle walk test (ESWT), respectively. A secondary aim was to determine whether any participant characteristics predicted those who did not demonstrate improvements on a repeat ISWT or ESWT...
January 1, 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/28840753/comparative-effectiveness-of-indacaterol-glycopyrronium-in-the-treatment-of-chronic-obstructive-pulmonary-disease
#14
Mario Cazzola, Paola Rogliani
Indacaterol/glycopyrronium has been the first long-acting β2-agonist (LABA)/long-acting muscarinic antagonist (LAMA) fixed dose combination to be approved as a maintenance treatment in chronic obstructive pulmonary disease patients. Comparative effectiveness studies indicate that it is constantly superior to a LAMA or a LABA alone or even a LABA/inhaled corticosteroid combination, regardless of the drugs used. However, definitive data documenting the benefit of indacaterol/glycopyrronium fixed dose combination over these consolidated therapies are still absent in real-world, although the results of pivotal randomized controlled trials show that this is the case...
August 25, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28838685/efficacy-and-safety-of-glycopyrrolate-eflow-%C3%A2-cs-nebulized-glycopyrrolate-in-moderate-to-very-severe-copd-results-from-the-glycopyrrolate-for-obstructive-lung-disease-via-electronic-nebulizer-golden-3-and-4-randomized-controlled-trials
#15
Edward Kerwin, James F Donohue, Thomas Goodin, Robert Tosiello, Alistair Wheeler, Gary T Ferguson
BACKGROUND: SUN-101 is a combination of glycopyrrolate delivered through an innovative, electronic nebulizer, intended for the treatment of patients with COPD. The objective of this study was to assess the efficacy and safety of this new drug device combination. METHODS: Replicate Phase III randomized, double-blind, placebo-controlled studies were conducted to evaluate the efficacy and safety of glycopyrrolate solution administered by an investigational eFlow(®) Closed System (eFlow(®) CS) nebulizer in subjects with moderate-to-very-severe COPD, including those with continued background use of a long-acting beta2-agonist ± inhaled corticosteroid and/or history of cardiovascular (CV) disease...
July 19, 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28837015/conserving-quality-of-life-through-community-paramedics
#16
Christopher Ashton, Denise Duffie, Jeffrey Millar
The Economic Value of Community Paramedicine Programs Study was a randomized controlled trial in two Eastern Ontario communities ߝ one urban and one rural ߝ to determine whether community paramedicine services (the intervention through home visits) would have a positive economic impact through influencing self-perceived quality of life and determining a monetized value. A total of 200 clients who were high-users of healthcare services and had one or more of five chronic diseases (congestive heart failure, chronic obstructive pulmonary disease, hypertension, stroke and diabetes) were recruited in early 2015...
2017: Healthcare Quarterly
https://www.readbyqxmd.com/read/28836871/effectiveness-of-smartphone-devices-in-promoting-physical-activity-and-exercise-in-patients-with-chronic-obstructive-pulmonary-disease-a-systematic-review
#17
María Del M Martínez-García, Juan D Ruiz-Cárdenas, Roberto A Rabinovich
The objectives of this systematic review were to analyse existing evidence on the efficacy of smartphone devices in promoting physical activity (PA) in patients with chronic obstructive pulmonary disease (COPD) and to identify the validity and precision of their measurements. A systematic review was undertaken across nine electronic databases: WOS Core Collection, PubMed, CINAHL, AMED, Academic Search Complete, Cochrane Central Register of Controlled Trials, SciELO, LILACS and ScienceDirect. Randomized and non-randomized controlled clinical trials were identified...
August 24, 2017: COPD
https://www.readbyqxmd.com/read/28831250/an-evaluation-of-activity-tolerance-patient-reported-outcomes-and-satisfaction-with-the-effectiveness-of-pulmonary-daoyin-on-patients-with-chronic-obstructive-pulmonary-disease
#18
Hai-Long Zhang, Jian-Sheng Li, Xue-Qing Yu, Su-Yun Li, Upur Halmurat, Yang Xie, Yan-Fang Wang, Feng-Sen Li, Ming-Hang Wang
BACKGROUND AND OBJECTIVE: Pulmonary Daoyin (PD) (evolved from ancient Chinese daoyin skills), is a rehabilitation technology that combines specially designed movements of the arms and body and controlled breathing exercises, to improve the physiological and psychological status of patients with chronic respiratory disease. Pulmonary rehabilitation is effective for patients with chronic obstructive pulmonary disease (COPD), and the efficacy of PD is unknown. The aim of this study is to investigate the effect of a PD program in enhancing activity tolerance, patient-reported outcomes and satisfaction with the effectiveness on patients with COPD...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28818057/effect-of-counselling-during-pulmonary-rehabilitation-on-self-determined-motivation-towards-physical-activity-in-people-with-chronic-obstructive-pulmonary-disease-protocol-of-a-mixed-methods-study
#19
Anne-Kathrin Rausch-Osthoff, Nicola Greco, Ariane Schwank, Swantje Beyer, David Gisi, Mandy Scheermesser, André Meichtry, Noriane Sievi, Thomas Hess, Markus Wirz
BACKGROUND: Physical activity promotion in people with Chronic Obstructive Pulmonary Disease (COPD) is focus of research and public health. Patient-centred interventions like counselling are promising approaches to help patients reducing sedentary behaviour. Aim of the present study is to investigate if a physical activity counselling program during pulmonary rehabilitation increases physical activity level in daily life in people with COPD. METHODS: A two-armed, single blind randomised controlled trial including 56 people with COPD will be conducted in an outpatient pulmonary rehabilitation...
August 17, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28814855/effect-of-carbocisteine-on-patients-with-copd-a-systematic-review-and-meta-analysis
#20
Zheng Zeng, Dan Yang, Xiaoling Huang, Zhenliang Xiao
BACKGROUND: COPD is the fourth leading cause of death in the world. It is a common, progressive, treatable and preventable disease. The exacerbation of COPD is associated with the peripheral muscle force, forced expiratory volume in 1 second (FEV1), the quality of life and mortality. Many studies indicated that the mucoactive medicines could reduce the exacerbations of COPD. This study summarized the efficacy of carbocisteine as a treatment for COPD. METHODS: We searched the randomized controlled trials (RCTs) following electronic bibliographic databases: MedLine, Embase, Cochrane Library and Web of Science...
2017: International Journal of Chronic Obstructive Pulmonary Disease
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