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https://www.readbyqxmd.com/read/29763572/determinants-of-response-to-roflumilast-in-severe-copd-pooled-analysis-of-two-randomized-trials
#1
Fernando J Martinez, Klaus F Rabe, Peter M A Calverley, Leonardo M Fabbri, Sanjay Sethi, Emilio Pizzichini, Andrew McIvor, Antonio Anzueto, Vijay K T Alagappan, Shahid Siddiqui, Colin Reisner, Sofia Zetterstrand, Jonas Román, Debasree Purkayastha, Nitin Bagul, Stephen I Rennard
RATIONALE: Roflumilast reduces exacerbations in patients with severe chronic obstructive pulmonary disease associated with chronic bronchitis and a history of exacerbations. Further characterization of patients most likely to benefit is warranted. OBJECTIVES: Define characteristics that most robustly identify patients who derive greatest exacerbation risk reduction with roflumilast. METHODS: Predefined, pooled analyses of REACT (NCT01329029) and RE2 SPOND (NCT01443845) multicenter, randomized, double-blind, placebo-controlled studies...
May 15, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29761573/using-fat-to-fight-disease-a-systematic-review-of-non-homologous-adipose-derived-stromal-stem-cell-therapies
#2
REVIEW
Marjorie E Bateman, Amy L Strong, Jeffrey M Gimble, Bruce A Bunnell
OBJECTIVE: The objective of this review is to describe the safety and efficacy of ASC and SVF in treating common diseases and the next steps in research that must occur prior to clinical use. EVIDENCE REVIEW: Pubmed, Ovid Medline, Embase, Web of Science, and the Cochrane Library were searched for articles about use of SVF or ASC for disease therapy published between 2012 and 2017. One meta-analysis, 2 randomized controlled trials, and 16 case series were included, representing 844 human patients...
May 15, 2018: Stem Cells
https://www.readbyqxmd.com/read/29744054/a-quick-relaxation-exercise-for-people-with-chronic-obstructive-pulmonary-disease-explorative-randomized-controlled-trial
#3
Eleonora Volpato, Paolo Banfi, Antonello Nicolini, Francesco Pagnini
Background: People with Chronic Obstructive Pulmonary Disease (COPD) suffer from dyspnoea, which may be increased by anxiety. Previous studies suggest that relaxation techniques may have positive effects in pulmonary rehabilitation. The main aim of this study is to explore the clinical impact of a quick, one-session, relaxation training for people with COPD. Methods: In this perspective, 38 participants with COPD were recruited and randomly assigned to listen to a relaxing audio or to watch a neutral stimulus, during their routine exams...
2018: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/29713157/effectiveness-of-meditative-movement-on-copd-a-systematic-review-and-meta-analysis
#4
REVIEW
Lu-Ling Wu, Zheng-Kun Lin, Hui-Dan Weng, Qiao-Fang Qi, Jun Lu, Kai-Xiong Liu
Background: The effectiveness of meditative movement (tai chi, yoga, and qigong) on COPD remained unclear. We undertook a systematic review and meta-analysis to determine the effectiveness of meditative movement on COPD patients. Methods: We searched PubMed, Web of Science, EMBASE, and the Cochrane Center Register of Controlled Trials for relevant studies. The methods of standard meta-analysis were utilized for identifying relevant researches (until August 2017), quality appraisal, and synthesis...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29706089/mortality-in-advanced-chronic-obstructive-pulmonary-disease-and-heart-failure-following-cardiopulmonary-rehabilitation
#5
Youjeong Kang, Bonnie G Steele, Robert L Burr, Cynthia M Dougherty
Cardiopulmonary rehabilitation (CR) improves physical function and quality of life (QoL) in chronic obstructive pulmonary disease (COPD) and heart failure (HF), but it is unknown if CR improves outcomes in very severe disease. This study's purpose was to describe functional capacity (6-min walk distance [6MWD], steps/day), symptoms (dyspnea, depression), QoL (Short-Form Health Survey-Veterans [SF-36 V]) and cardiopulmonary function ( N-terminal pro-brain natriuretic peptide [NT-proBNP], forced expiratory volume in 1 s [FEV1 ]), and derive predictors of mortality among patients with severe COPD and HF who participated in CR...
January 1, 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29705783/combination-therapy-of-inhaled-indacaterol-glycopyrronium-for-chronic-obstructive-pulmonary-disease-in-the-very-elderly-is-it-safe-an-electrocardiographic-evaluation
#6
Francesco Spannella, Federico Giulietti, Valentina Cesari, Antonio Francioso, Guido Cocci, Laura Landi, Francesca Elena Lombardi, Elisabetta Borioni, Beatrice Bernardi, Giulia Rosettani, Valentina Bordoni, Corrado Iacoacci, Piero Giordano, Riccardo Sarzani
Cardiovascular (CV) comorbidities in patients with chronic obstructive pulmonary disease (COPD) are associated with increased morbidity and mortality, especially in old and very old subjects. The question if long-acting beta-agonist and long-acting muscarinic antagonist could be associated with the increased prevalence of CV-related adverse effects has puzzled, particularly in the past, specialists involved in the management of respiratory diseases. The safety of these compounds has scarcely been tested in patients aged ≥ 65 years with CV comorbidities, since randomized controlled trials rarely include this subpopulation...
2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29705482/the-effect-of-progressive-muscle-relaxation-on-the-management-of-fatigue-and-quality-of-sleep-in-patients-with-chronic-obstructive-pulmonary-disease-a-randomized-controlled-clinical-trial
#7
Pooya Seyedi Chegeni, Mohammad Gholami, Alireza Azargoon, Amir Hossein Hossein Pour, Mehdi Birjandi, Hamed Norollahi
OBJECTIVE: To assess the effect of progressive muscle relaxation (PMR) on fatigue and sleep quality of patients with chronic obstructive pulmonary disease (COPD) stages 3 and 4. MATERIALS AND METHODS: The pretest posttest clinical trial recruited 91 patients COPD grades 3 and 4. Following random assignment of subjects, the treatment group (n = 45) performed PMR for eight weeks and the control group (n = 46) received routine cares. At baseline and after the intervention, fatigue and sleep quality was assessed...
May 2018: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29705218/acute-tetrahydrobiopterin-improves-endothelial-function-in-patients-with-copd
#8
Paula Rodriguez-Miguelez, Justin Gregg, Nichole Seigler, Leon Bass, Jeffrey Thomas, Jennifer S Pollock, Jennifer C Sullivan, Thomas A Dillard, Ryan A Harris
BACKGROUND: Cardiovascular diseases represent a hallmark characteristic in chronic obstructive pulmonary disease (COPD), and endothelial dysfunction has been observed in these patients. Tetrahydrobiopterin (BH4 ) is an essential cofactor for nitric oxide (NO) synthesis and a regulator of endothelial function. This study sought to test the hypothesis that a single dose of BH4 would improve endothelial function in patients with COPD via an increase in NO bioavailability. METHODS: 17 patients with COPD completed a randomized, double blind, placebo-controlled, crossover trial with an acute dose of either BH4 (Kuvan® , BioMarin Pharmaceuticals) or placebo (PLC)...
April 26, 2018: Chest
https://www.readbyqxmd.com/read/29695902/randomized-double-blind-placebo-controlled-trial-to-assess-the-efficacy-and-safety-of-three-doses-of-co-suspension-delivery-technology-glycopyrronium-mdi-in-japanese-patients-with-moderate-to-severe-copd
#9
Yasushi Fukushima, Yuji Nakatani, Yumiko Ide, Hisakuni Sekino, Earl St Rose, Shahid Siddiqui, Andrea Maes, Colin Reisner
Purpose: Due to the burden of COPD in Japan, new pharmacologic treatments are needed to meet patient requirements. This study assessed the efficacy and safety of glycopyrronium (GP) delivered via metered dose inhaler (MDI) in Japanese patients with moderate-to-severe COPD. Methods: This Phase IIb, multicenter, randomized, double-blind, 7-day, crossover study compared GP MDI 28.8, 14.4, and 7.2 μg with placebo MDI (all administered as two inhalations, twice daily)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29690786/feasibility-study-to-assess-the-effect-of-a-brief-mindfulness-intervention-for-patients-with-chronic-obstructive-pulmonary-disease-a-randomized-controlled-trial
#10
Linda Perkins-Porras, Muhammad Riaz, Adeoba Okekunle, Svitlana Zhelezna, Indranil Chakravorty, Michael Ussher
Psychological distress is common among patients with chronic obstructive pulmonary disease (COPD). This study aimed to assess whether a 10-minute mindfulness intervention reduces distress and breathlessness, improves mood and increases mindfulness among hospital inpatients following acute exacerbation of COPD.Fifty patients were recruited following an acute admission. The immediate effects of a 10-minute mindfulness-based body scan were compared with a control intervention. Participants were randomized to receive either a mindfulness-based body scan ( n = 24) or a control condition ( n = 26) via a 10-minute audio recording...
January 1, 2018: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/29683370/nutritional-supplement-bao-khi-khang-as-an-adjuvant-therapy-in-acute-exacerbations-of-chronic-obstructive-pulmonary-disease
#11
Ba X Hoang, Bo Han, Hoang X Nguyen, Khanh T Dang
To investigate the effectiveness of nutritional supplement Bao Khi Khang as an adjuvant therapy in acute exacerbations of chronic obstructive pulmonary disease (COPD) compared to conventional therapy alone. This was a prospective, randomized, open-label controlled trial in 60 patients presenting with acute exacerbation of COPD. Patients were randomized into two groups, the control and the experimental groups. The control group was treated with the standard therapeutic protocol (Antimicrobial+Corticosteroids+Bronchodilator+Mucolytic drugs)...
April 23, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29679596/observational-studies-of-inhaled-corticosteroid-effectiveness-in-copd-lessons-learned
#12
Samy Suissa, Pierre Ernst
BACKGROUND: Randomized controlled trials at times investigate findings suggested by observational studies. For example, the TORCH trial, which did not show a mortality reduction with inhaled corticosteroids (ICS) in chronic obstructive pulmonary disease (COPD), was motivated by some observational studies that suggested considerable reductions in mortality with these drugs. Reasons for these discrepancies are unclear. METHODS: We searched the literature to identify all observational studies, including cohort and case-control studies, investigating the effectiveness of ICS on major outcomes in COPD patients, including death and hospitalization for COPD...
April 18, 2018: Chest
https://www.readbyqxmd.com/read/29664681/effect-of-bronchodilation-and-exercise-training-with-behavior-modification-on-exercise-tolerance-and-downstream-effects-on-symptoms-and-physical-activity-in-copd
#13
Thierry Troosters, François Maltais, Nancy Leidy, Kim L Lavoie, Maria Sedeno, Wim Janssens, Judith Garcia-Aymerich, Damijan Erzen, Dorothy De Sousa, Lawrence Korducki, Alan Hamilton, Jean Bourbeau
RATIONALE: Bronchodilation and exercise training (ExT) improve exercise tolerance in patients with chronic obstructive pulmonary disease (COPD); however, behavior modification is required to impact on daily physical activity (PA). OBJECTIVES: To assess whether tiotropium/olodaterol, ±ExT, would improve exercise endurance time (EET) and PA compared with placebo in patients participating in a self-management behavior-modification (SMBM) program. METHODS: A 12-week, randomized, partially double-blind, placebo-controlled, parallel-group trial in patients with COPD (PHYSACTO®; NCT02085161)...
April 17, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29663044/procalcitonin-algorithm-to-guide-initial-antibiotic-therapy-in-acute-exacerbations-of-copd-admitted-to-the-icu-a-randomized-multicenter-study
#14
Cédric Daubin, Xavier Valette, Fabrice Thiollière, Jean-Paul Mira, Pascal Hazera, Djillali Annane, Vincent Labbe, Bernard Floccard, François Fournel, Nicolas Terzi, Damien Du Cheyron, Jean-Jacques Parienti
PURPOSE: To compare the efficacy of an antibiotic protocol guided by serum procalcitonin (PCT) with that of standard antibiotic therapy in severe acute exacerbations of COPD (AECOPDs) admitted to the intensive care unit (ICU). METHODS: We conducted a multicenter, randomized trial in France. Patients experiencing severe AECOPDs were assigned to groups whose antibiotic therapy was guided by (1) a 5-day PCT algorithm with predefined cutoff values for the initiation or stoppage of antibiotics (PCT group) or (2) standard guidelines (control group)...
April 16, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29649849/-copd-importance-of-lung-function-testing-for-diagnosis-and-treatment
#15
Wolfram Windisch, Carl Peter Criée
Pulmonary function testing is essential for diagnosis and treatment-guidance of chronic obstructive pulmonary disease (COPD). Airway obstruction as assessed by spirometry should follow the reference-values provided by the Global Lung Initiative (GLI) of the European Respiratory Society (ERS). In addition, lung function testing should also include the assessment of lung hyperinflation and pulmonary emphysema by full-body plethysmography and determination of diffusion capacity. This is important since both, lung hyperinflation and pulmonary emphysema, can present without existing airway obstruction...
April 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29643055/findings-of-the-chronic-obstructive-pulmonary-disease-sitting-and-exacerbations-trial-copd-seat-in-reducing-sedentary-time-using-wearable-and-mobile-technologies-with-educational-support-randomized-controlled-feasibility-trial
#16
Mark W Orme, Amie E Weedon, Paula M Saukko, Dale W Esliger, Mike D Morgan, Michael C Steiner, John W Downey, Lauren B Sherar, Sally J Singh
BACKGROUND: Targeting sedentary time post exacerbation may be more relevant than targeting structured exercise for individuals with chronic obstructive pulmonary disease. Focusing interventions on sitting less and moving more after an exacerbation may act as a stepping stone to increase uptake to pulmonary rehabilitation. OBJECTIVE: The aim of this paper was to conduct a randomized trial examining trial feasibility and the acceptability of an education and self-monitoring intervention using wearable technology to reduce sedentary behavior for individuals with chronic obstructive pulmonary disease admitted to hospital for an acute exacerbation...
April 11, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29629402/the-short-term-impact-of-symptom-defined-copd-exacerbation-recovery-on-health-status-and-lung-function
#17
Lindsey T Murray, Nancy K Leidy
Background: This study examined the short-term effects of symptom-defined exacerbation recovery on health status and pulmonary function in moderate to severe chronic obstructive pulmonary disease (COPD) patients. Methods: Secondary analyses of pooled data from two 12-week Phase II international, randomized controlled trials using the EXA cerbations of C hronic Pulmonary Disease T ool (EXACT) to identify symptom-defined exacerbations were conducted. Recovery was categorized as recovered, unrecovered (persistent worsening), or censored...
January 24, 2018: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://www.readbyqxmd.com/read/29629400/long-term-evaluation-of-the-effects-of-aclidinium-bromide-on-major-adverse-cardiovascular-events-and-copd-exacerbations-in-patients-with-moderate-to-very-severe-copd-rationale-and-design-of-the-ascent-copd-study
#18
Robert A Wise, Kenneth R Chapman, Benjamin M Scirica, David A Schoenfeld, Deepak L Bhatt, Sami Z Daoud, Beatriz Seoane, Colin Reisner, Esther Garcia Gil
Introduction: Chronic obstructive pulmonary disease (COPD) is a heterogeneous illness characterized by persistent airflow obstruction and exacerbations. Patients typically experience a decline in lung function, increasingly impaired health-related quality of life, and high mortality. Poor lung function and exacerbations are associated with an increased risk of cardiovascular (CV) and cerebrovascular events, and approximately 30% of patients with COPD die from CV‑related disease. Treatment with inhaled long-acting bronchodilators, such as long-acting muscarinic antagonists (LAMAs), is recommended; however, some studies have suggested that LAMAs may increase the risk of CV events...
January 24, 2018: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://www.readbyqxmd.com/read/29628896/inflammatory-and-metabolic-responses-to-different-resistance-training-on-chronic-obstructive-pulmonary-disease-a-randomized-control-trial
#19
Bruna S de Alencar Silva, Fábio S Lira, Fabrício E Rossi, Dionei Ramos, Juliana S Uzeloto, Ana P C F Freire, Fabiano F de Lima, Luís A Gobbo, Ercy M C Ramos
Background: Low-grade inflammation can be present in chronic obstructive pulmonary disease (COPD), which may affect the regulation of muscle protein and body metabolism. Regular exercise show improvement in muscle strength and dyspnea in patients with COPD, however, the response to training on inflammatory and metabolic disorders is unclear. In this study, we compared the effects of resistance training using weight machines and elastic resistance (bands and tubes) on the inflammatory and metabolic responses in patients with COPD...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29628759/the-development-of-azd7624-for-prevention-of-exacerbations-in-copd-a-randomized-controlled-trial
#20
Naimish R Patel, Danen M Cunoosamy, Malin Fagerås, Ziad Taib, Sara Asimus, Tove Hegelund-Myrbäck, Sofia Lundin, Katerina Pardali, Nisha Kurian, Eva Ersdal, Cecilia Kristensson, Katarina Korsback, Robert Palmér, Mary N Brown, Steven Greenaway, Leonard Siew, Graham W Clarke, Stephen I Rennard, Barry J Make, Robert A Wise, Paul Jansson
Background: p38 mitogen-activated protein kinase (MAPK) plays a central role in the regulation and activation of pro-inflammatory mediators. COPD patients have increased levels of activated p38 MAPK, which correlate with increased lung function impairment, alveolar wall inflammation, and COPD exacerbations. Objectives: These studies aimed to assess the effect of p38 inhibition with AZD7624 in healthy volunteers and patients with COPD. The principal hypothesis was that decreasing lung inflammation via inhibition of p38α would reduce exacerbations and improve quality of life for COPD patients at high risk for acute exacerbations...
2018: International Journal of Chronic Obstructive Pulmonary Disease
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