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https://www.readbyqxmd.com/read/29775021/-the-correlation-between-radiological-classification-and-clinical-audiometry-in-otosclerosis
#1
Y Ren, K Wang, J Q Zhang
Objective: The aim of this study is to explore the correlation between radiological classification on HRCT and effects on surgery with hearing improvement in otosclerosis. Method: Thirty three patients (66 ears) with otosclerosis were enrolled to this study, who would be done operation using Fischs stapes surgery technique. All patients were classified according to axial HRCT preoperatively. All patients were evaluated by pure tone test preoperatively and 6 months postoperatively. Correlation between radiological classification and hearing effects were studied...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29773417/stapes-surgery-preserving-the-superstructure-of-stapes-takagi-s-stapedotomy-in-otosclerosis-a-retrospective-study-of-24-consecutive-cases
#2
Shin-Ichi Sato, Akira Takagi, Takashi Fujiwara
OBJECTIVE: The aim of this study was to evaluate the hearing outcomes and complications of stapedotomy in which the stapes superstructure was preserved (Takagi's stapedotomy). In this surgical approach, the lenticular process of the incus rather is removed, than the superstructure of the stapes. METHODS: A single-center retrospective observational study was performed. We included all patients having Takagi's stapedotomy for otosclerosis between January 2005 and April 2016...
May 14, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29748449/risk-factors-of-tympanoplasties-in-long-term-observation
#3
Joanna Janiak-Kiszka, Wojciech Kaźmierczak, Kinga Lewandowska, Mateusz Grabowski, Henryk Kaźmierczak, Łukasz Kluczyński
OBJECTIVES: The aim of the study was to evaluate risk factors influencing the results of tympanoplasties on the base of material taken from the Department of Otolaryngology and Laryngological Oncology Collegium Medicum of Nicolaus Copernicus University in Bydgoszcz between 2004-2009. In this period 98 operations were done. The time from operation to hearing examination was 3 to 7 years, mean 5,43. Tympanoplastic operation were divided according to Tos classification. Measuring hearing results, tonal audiometry was done and mean air bone gap on four frequencies was assesed (500, 1000, 2000, 3000 Hz), according to AAO-HNS guidelines (1995)...
April 30, 2018: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29747060/acoustic-stimulation-on-the-round-window-for-active-middle-ear-implants
#4
Kiwoong Seong, Kyuyup Lee, Sunil Puria, Jin-Ho Cho
Many clinical reports have discussed the effectiveness of stimulating the ear's round window (RW) with a tool to mitigate conductive and mixed hearing loss. The RW is one of the two openings from the middle ear into the inner ear. Various methods have been proposed to construct a highly efficient, easily implanted, and reliable RW transducer. Devices, however, such as floating mass transducers, have difficulty establishing proper contact without some degree of bone incision around the RW. Additionally, vibration energy may not be fully transmitted to the cochlea, but instead will be spread through the soft tissue around the transducer...
May 2, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29728750/evidence-of-distinct-reln-and-tgfb1-genetic-associations-in-familial-and-non-familial-otosclerosis-in-a-british-population
#5
Andrew J Mowat, Michael Crompton, Joanna L Ziff, Christopher P Aldren, Jeremy A Lavy, Shakeel R Saeed, Sally J Dawson
Otosclerosis is a common form of hearing loss which typically presents in young adults. The disease has a familial, monogenic form and a non-familial form with a more complex aetiology. A previous genome wide association study identified evidence that variants within RELN are associated with the condition. Other genes in which an association has been reported include BMP2, COL1A1, FGF2, PPP2R5B and TGFB1. However, follow up studies have often failed to replicate initial positive results. The aim of this study was to establish if an association exists between eight single nucleotide polymorphisms (SNPs) in these six previously implicated genes and otosclerosis in a British case-control cohort (n = 748)...
May 4, 2018: Human Genetics
https://www.readbyqxmd.com/read/29698958/vibrant-soundbridge-implantation-floating-mass-transducer-coupled-with-the-stapes-head-and-embedded-in-fat
#6
Qingsong Liu, Guodong Feng, Yingying Shang, Suju Wang, Zhiqiang Gao
Subtotal petrosectomy may be performed for refractory chronic middle ear diseases, such as massive cholesteatoma or recurrent otitis media. It involves permanent obliteration of the operative cavity, thus precluding the chance to restore conductive hearing via traditional inertial ossicular prostheses. The Vibrant Soundbridge (VSB) is an alternative option for hearing rehabilitation. Vibrant energy is delivered into the inner ear via a floating mass transducer (FMT), which can be coupled with any part of the middle ear acoustic transmission structure...
April 26, 2018: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/29664867/short-and-long-term-outcomes-of-titanium-clip-ossiculoplasty
#7
Charissa N Kahue, Brendan P O'Connnell, Matthew M Dedmon, David S Haynes, Alejandro Rivas
OBJECTIVE: To report short (∼4 mo) and long-term (>12 mo) audiometric outcomes following ossiculoplasty using a titanium clip partial ossicular reconstruction prosthesis. METHODS: Case series at a single tertiary referral center reviewing 130 pediatric and adult patients with conductive hearing loss (CHL) secondary to chronic otitis media (n = 121, 93%) or traumatic ossicular disruption (n = 9, 7%) who underwent partial ossiculoplasty from January 2005 to December 2015 with the CliP prosthesis...
April 16, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29661578/optimization-of-the-etch-and-rinse-technique-new-perspectives-to-improve-resin-dentin-bonding-and-hybrid-layer-integrity-by-reducing-residual-water-using-dimethyl-sulfoxide-pretreatments
#8
Thiago Henrique Scarabello Stape, Leo Tjäderhane, Gabriel Abuna, Mário Alexandre Coelho Sinhoreti, Luís Roberto Marcondes Martins, Arzu Tezvergil-Mutluay
OBJECTIVE: To determine whether bonding effectiveness and hybrid layer integrity on acid-etched dehydrated dentin would be comparable to the conventional wet-bonding technique through new dentin biomodification approaches using dimethyl sulfoxide (DMSO). METHODS: Etched dentin surfaces from extracted sound molars were randomly bonded in wet or dry conditions (30s air drying) with DMSO/ethanol or DMSO/H2 O as pretreatments using a simplified (Scotchbond Universal Adhesive, 3M ESPE: SU) and a multi-step (Adper Scotchbond Multi-Purpose, 3M ESPE: SBMP) etch-and-rinse adhesives...
April 13, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29658107/malleostapedotomy-in-stapes-revision-surgery-is-an-endoscopic-approach-possible
#9
Giannicola Iannella, Diletta Angeletti, Alessandra Manno, Benedetta Pasquariello, Massimo Re, Giuseppe Magliulo
OBJECTIVES/HYPOTHESIS: The purpose of the present study was to show our preliminary results regarding the endoscopic ear surgery application in malleostapedotomy surgery. STUDY DESIGN: Case series. METHODS: Six patients (four females and two males) who underwent endoscopic ear surgery as revision surgery for otosclerosis were enrolled in this study. For endoscopic malleostapedotomy surgery, rigid angled endoscopes at 0 ° and 30 ° with a length of 14 cm and an outer diameter of 3 and 4 mm were used...
April 15, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29649044/oval-window-size-and-shape-a-micro-ct-anatomical-study-with-considerations-for-stapes-surgery
#10
Matthew J Zdilla, Janusz Skrzat, Magdalena Kozerska, Bartosz Leszczyński, Jacek Tarasiuk, Sebastian Wroński
BACKGROUND: The oval window is an important structure with regard to stapes surgeries, including stapedotomy for the treatment of otosclerosis. Recent study of perioperative imaging of the oval window has revealed that oval window niche height can indicate both operative difficulty and subjective discomfort during otosclerosis surgery. With regard to shape, structures incorporated into the oval window niche, such as cartilage grafts, must be compatible with the shape of the oval window...
April 11, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29649043/permeation-enhancers-for-intratympanically-applied-drugs-studied-using-fluorescent-dexamethasone-as-a-marker
#11
Wei Li, Jared J Hartsock, Chunfu Dai, Alec N Salt
HYPOTHESIS: Entry of locally applied drugs into the inner ear can be enhanced by chemical manipulations. BACKGROUND: Perilymph drug concentrations achieved by intratympanic applications are well below the applied concentration due to limited entry through the round window (RW) membrane and stapes. Chemical manipulations to increase entry permeability could increase the effectiveness of drug therapy with local applications. METHODS: Dexamethasone-fluorescein (F-dex) was used as an entry marker...
April 11, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29619098/short-term-audiological-results-of-diode-laser-in-comparison-with-manual-perforation-in-stapes-surgery
#12
Rogerio Hamerschmidt, Stephanie Sbizera Saab, Bettina Carvalho, Carolina do Carmo
Introduction  Diode laser is a new alternative in stapes surgery for otosclerosis. The present study is the first to compare the short-term results of the surgery performed using diode laser to those obtained through the conventional fenestration technique. Objective  To use audiometry to establish a comparative analysis between the functional results obtained through surgery for otosclerosis using diode laser and the conventional technique. Method  Audiometric evaluation of 12 patients submitted to stapes surgery for otosclerosis, using diode laser or conventional fenestration by needle and drills, between 2014 and 2015...
April 2018: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29605356/autosomal-dominant-stapes-fixation-syndactyly-and-symphalangism-in-a-family-with-nog-mutation-long-term-follow-up-on-surgical-treatment
#13
Marie Westergaard-Nielsen, Tine Amstrup, Jens Højberg Wanscher, Klaus Brusgaard, Lilian Bomme Ousager
OBJECTIVE: Evaluation of clinical findings and audiological outcome after surgery in a Danish family with autosomal dominant facio-audio-symphalangism syndrome with stapes fixation, syndactyly and symphalangism. METHODS: Retrospective report on eight affected family members in a Danish family. Clinical investigation included X-ray, audiology and in one case video-recorded surgery. Main outcome measure was audiologic results after stapedectomy. Sanger DNA sequencing of NOG was performed on peripheral blood...
May 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29593164/effect-of-various-dimethyl-sulfoxide-concentrations-on-the-durability-of-dentin-bonding-and-hybrid-layer-quality
#14
Anas Aaqel Salim Al-Ani, Murat Mutluay, Thiago Henrique Scarabello Stape, Leo Tjäderhane, Arzu Tezvergil-Mutluay
The objective was to evaluate effect of dimethyl sulfoxide (DMSO) on microtensile bond strength (µTBS) and nanoleakage (NL). Superficial dentin was acid-etched and pretreated with DMSO. Etch-and-rinse adhesive was applied and restored with resin composite incrementally. After 24 h, teeth were sectioned, stored in artificial saliva for 24-h or 6-months before µTBS evaluation. Failure modes were examined. Six beams per group were submitted to nanoleakage evaluation using SEM. Data were analyzed using ANOVA and Tukey's test (α=0...
March 28, 2018: Dental Materials Journal
https://www.readbyqxmd.com/read/29570801/predictive-factors-in-995-stapes-surgeries-for-primary-otosclerosis
#15
Mohammad T Khorsandi A, Mir M Jalali, Vahideh Shoshi D
OBJECTIVES/HYPOTHESIS: This study sought to identify the predictors of outcome in patients with otosclerosis undergoing primary stapes surgery. STUDY DESIGN: Retrospective analysis of medical records. METHODS: A total of 995 patients with otosclerosis who underwent primary stapes surgery by a single surgeon between January 2006 and December 2016 were included. Logistic regression analysis was performed to examine factors affecting postoperative hearing thresholds at individual frequencies...
March 23, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29554036/response-changes-during-insertion-of-a-cochlear-implant-using-extracochlear-electrocochleography
#16
Christopher K Giardina, Tatyana E Khan, Stephen H Pulver, Oliver F Adunka, Craig A Buchman, Kevin D Brown, Harold C Pillsbury, Douglas C Fitzpatrick
OBJECTIVES: Electrocochleography is increasingly being utilized as an intraoperative monitor of cochlear function during cochlear implantation (CI). Intracochlear recordings from the advancing electrode can be obtained through the device by on-board capabilities. However, such recordings may not be ideal as a monitor because the recording electrode moves in relation to the neural and hair cell generators producing the responses. The purposes of this study were to compare two extracochlear recording locations in terms of signal strength and feasibility as intraoperative monitoring sites and to characterize changes in cochlear physiology during CI insertion...
March 16, 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29551306/pharmacokinetic-principles-in-the-inner-ear-influence-of-drug-properties-on-intratympanic-applications
#17
REVIEW
Alec N Salt, Stefan K Plontke
Local drug delivery to the ear has gained wide clinical acceptance, with the choice of drug and application protocol in humans largely empirically-derived. Here, we review the pharmacokinetics underlying local therapy of the ear using the drugs commonly used in clinical practice as examples. Based on molecular properties and perilymph measurements interpreted through computer simulations we now better understand the principles underlying entry and distribution of these and other drugs in the ear. From our analysis, we have determined that dexamethasone-phosphate, a pro-drug widely-used clinically, has molecular and pharmacokinetic properties that make it ill-suited for use as a local therapy for hearing disorders...
March 11, 2018: Hearing Research
https://www.readbyqxmd.com/read/29545254/anatomic-malformations-of-the-middle-and-inner-ear-in-22q11-2-deletion-syndrome-case-series-and-literature-review
#18
E Verheij, L Elden, T B Crowley, F A Pameijer, E H Zackai, D M McDonald-McGinn, H G X M Thomeer
BACKGROUND AND PURPOSE: The 22q11.2 deletion syndrome is characterized by a heterogenic phenotype, including hearing loss. The underlying cause of hearing loss, especially sensorineural hearing loss, is not yet clear. Therefore, our objective was to describe anatomic malformations in the middle and inner ear in patients with 22q11.2 deletion syndrome. MATERIALS AND METHODS: A retrospective case series was conducted in 2 tertiary referral centers. All patients with 22q11...
May 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29544621/la-ferrassie-1-new-perspectives-on-a-classic-neandertal
#19
Asier Gómez-Olivencia, Rolf Quam, Nohemi Sala, Morgane Bardey, James C Ohman, Antoine Balzeau
The La Ferrassie 1 (LF1) skeleton, discovered over a century ago, is one of the most important Neandertal individuals both for its completeness and due to the role it has played historically in the interpretation of Neandertal anatomy and lifeways. Here we present new skeletal remains from this individual, which include a complete right middle ear ossicular chain (malleus, incus, and stapes), three vertebral fragments, and two costal remains. Additionally, the study of the skeleton has allowed us to identify new pathological lesions, including a congenital variant in the atlas, a greenstick fracture of the left clavicle, and a lesion in a mid-thoracic rib of unknown etiology...
April 2018: Journal of Human Evolution
https://www.readbyqxmd.com/read/29533330/picosecond-infrared-laser-pirl-application-in-stapes-surgery-first-experience-in-human-temporal-bones
#20
Hannes Petersen, Alexandra Gliese, Yannick Stober, Stephanie Maier, Nils-Owe Hansen, Sebastian Kruber, Dennis Eggert, Miklós Tóth, Tobias Gosau, Hartmut Schlüter, Klaus Püschel, Udo Schumacher, Robert John Dwayne Miller, Adrian Münscher, Carsten Dalchow
OBJECTIVE: Using a contact-free laser technique for stapedotomy reduces the risk of mechanical damage of the stapes footplate. However, the risk of inner ear dysfunction due to thermal, acoustic, or direct damage has still not been solved. The objective of this study was to describe the first experiences in footplate perforation in cadaver tissue performed by the novel Picosecond-Infrared-Laser (PIRL), allowing a tissue preserving ablation. PATIENTS AND INTERVENTION: Three human cadaver stapes were perforated using a fiber-coupled PIRL...
April 2018: Otology & Neurotology
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