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https://www.readbyqxmd.com/read/29158536/validation-of-methods-for-prediction-of-clinical-output-levels-of-active-middle-ear-implants-from-measurements-in-human-cadaveric-ears
#1
Martin Grossöhmichen, Bernd Waldmann, Rolf Salcher, Nils Prenzler, Thomas Lenarz, Hannes Maier
Today, the standard method to predict output levels of active middle ear implants (AMEIs) before clinical data are available is stapes vibration measurement in human cadaveric ears, according to ASTM standard F2504-05. Although this procedure is well established, the validity of the predicted output levels has never been demonstrated clinically. Furthermore, this procedure requires a mobile and visually accessible stapes and an AMEI stimulating the ossicular chain. Thus, an alternative method is needed to quantify the output level of AMEIs in all other stimulation modes, e...
November 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29149722/effects-of-middle-ear-quasi-static-stiffness-on-sound-transmission-quantified-by-a-novel-3-axis-optical-force-sensor
#2
Ivo Dobrev, Jae Hoon Sim, Baktash Aqtashi, Alexander M Huber, Thomas Linder, Christof Röösli
BACKGROUND: Intra-operative quantification of the ossicle mobility could provide valuable feedback for the current status of the patient's conductive hearing. However, current methods for evaluation of middle ear mobility are mostly limited to the surgeon's subjective impression through manual palpation of the ossicles. This study investigates how middle ear transfer function is affected by stapes quasi-static stiffness of the ossicular chain. The stiffness of the middle ear is induced by a) using a novel fiber-optic 3-axis force sensor to quantify the quasi-static stiffness of the middle ear, and b) by artificial reduction of stapes mobility due to drying of the middle ear...
November 10, 2017: Hearing Research
https://www.readbyqxmd.com/read/29135864/patterns-of-extended-high-frequency-hearing-loss-following-stapes-surgery
#3
Melissa J Babbage, Greg A O'Beirne, Michael J Bergin, Philip A Bird
OBJECTIVE: Thresholds in the extended high-frequency (EHF) range (> 8 kHz) often worsen after otherwise successful stapedectomy. The aims of this study were to document the prevalence of hearing loss from 0.25 to 16 kHz after stapedectomy and the relative rates of transient and permanent EHF hearing loss. STUDY DESIGN: Prospective, observational, longitudinal. SETTING: Tertiary referral center. PATIENTS: Thirty-nine patients who underwent 44 primary or revision stapes surgeries...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29132143/a-jurassic-gliding-euharamiyidan-mammal-with-an-ear-of-five-auditory-bones
#4
Gang Han, Fangyuan Mao, Shundong Bi, Yuanqing Wang, Jin Meng
Gliding is a distinctive locomotion type that has been identified in only three mammal species from the Mesozoic era. Here we describe another Jurassic glider that belongs to the euharamiyidan mammals and shows hair details on its gliding membrane that are highly similar to those of extant gliding mammals. This species possesses a five-boned auditory apparatus consisting of the stapes, incus, malleus, ectotympanic and surangular, representing, to our knowledge, the earliest known definitive mammalian middle ear...
November 13, 2017: Nature
https://www.readbyqxmd.com/read/29130651/further-delineation-of-the-gdf6-related-multiple-synostoses-syndrome
#5
Paulien A Terhal, Nienke E Verbeek, Nine Knoers, Rutger J A J Nievelstein, Ans van den Ouweland, Ralph J Sakkers, Lucienne Speleman, Gijs van Haaften
A mutation in GDF6 was recently found to underlie a multiple synostoses syndrome. In this report, we describe the second family with GDF6-related multiple synostoses syndrome (SYNS4), caused by a novel c.1287C>A/p.Ser429Arg mutation in GDF6. In addition to synostoses of carpal and/or tarsal bones, at least 6 of 10 affected patients in this family have been diagnosed with mild to moderate hearing loss. In four of them otosclerosis was said to be present, one patient had hearing loss due to severe stapes fixation at the age of 6 years, providing evidence that hearing loss in the GDF6-related multiple synostoses syndrome can be present in childhood...
November 12, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29116963/an-objective-method-to-determine-the-electrically-evoked-stapedius-reflex-threshold-during-cochlea-implantation
#6
Bernhard G Weiss, Friederike Söchting, Mattis Bertlich, Martin Busch, Jenny Blum, Friedrich Ihler, Martin Canis
OBJECTIVE: In cochlea implantation, assessment of the electrically evoked stapedius reflex threshold (eSRT) provides information for postoperative adjustment of the speech processor. This is used to prevent undesired overstimulation. To this day, the reflex is visually identified by the surgeon. However, this method may be prone to error due to ventilation-associated situs excursions, blinking, or other distractions. Therefore, the aim of this study was to establish an objective and automatized method to determine the eSRT...
November 7, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29116384/living-with-otosclerosis-disease-specific-health-related-quality-of-life-measurement-in-patients-undergoing-stapes-surgery
#7
Susen Lailach, Tina Schenke, Ingo Baumann, Hannah Walter, Mark Praetorius, Thomas Beleites, Thomas Zahnert, Marcus Neudert
INTRODUCTION: Otosclerosis is associated with hearing disability, leading to communication deficits and social and psychological restrictions. The objective of our study was to analyze disease-specific health-related quality of life (HRQOL) after stapes surgery and compare the outcome of HRQOL with audiometric parameters. SUBJECTS AND METHODS: Our clinical case study was conducted at two tertiary referral centers. All the 37 patients who had undergone stapes surgery were analyzed clinically and by audiometric testing (pure tone and speech audiometry) in the pre- and postoperative settings...
November 7, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29105767/the-relationship-between-endolymphatic-hydrops-in-the-vestibule-and-low-frequency-air-bone-gaps
#8
Satofumi Sugimoto, Tadao Yoshida, Masaaki Teranishi, Yuriko Okazaki, Shinji Naganawa, Michihiko Sone
OBJECTIVES/HYPOTHESIS: To investigate the relationship between endolymphatic hydrops and hearing level, focusing on significant vestibular endolymphatic hydrops adjacent to the stapes footplate and low-frequency air-bone gaps. STUDY DESIGN: Retrospective study. METHODS: The study included 1,548 ears from 775 patients who underwent magnetic resonance imaging examination in our university hospital to investigate possible endolymphatic hydrops between January 2012 and December 2015...
November 6, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29095508/laser-assisted-fixation-of-a-nitinol-stapes-prosthesis
#9
Florian Schrötzlmair, Fabian Suchan, Thomas Pongratz, Eike Krause, Joachim Müller, Ronald Sroka
BACKGROUND AND OBJECTIVE: Otosclerosis is an inner ear bone disease characterized by fixation of the stapes and consequently progressive hearing loss. One treatment option is the surgical replacement of the stapes by a prosthesis. When so called "smart materials" like nitinol are used, prosthesis fixation can be performed using a laser without manual crimping on the incus. However, specific laser-prosthesis interactions have not been described yet. The aim of the present study was to elucidate the thermo-mechanical properties of the NiTiBOND® prosthesis as a basis for handling instructions for laser-assisted prosthesis fixation...
November 2, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29084088/intracochlear-measurements-of-interaural-time-and-level-differences-conveyed-by-bilateral-bone-conduction-systems
#10
Nyssa F Farrell, Renee M Banakis Hartl, Victor Benichoux, Andrew D Brown, Stephen P Cass, Daniel J Tollin
HYPOTHESIS: Intracochlear pressures (PIC) and stapes velocity (Vstap) elicited by bilaterally placed bone-anchored hearing devices (BAHD) will be systematically modulated by imposed interaural time (ITD) and level differences (ILD), demonstrating the potential for users of bilateral BAHD to access these binaural cues. BACKGROUND: BAHD are traditionally implanted unilaterally under the assumption that transcranial cross-talk limits interaural differences. Recent studies have demonstrated improvements in binaural and spatial performance with bilateral BAHD; however, objective measures of binaural cues from bilateral BAHDs are lacking...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29073906/hdr-syndrome-with-a-novel-mutation-in-gata3-mimicking-a-congenital-x-linked-stapes-gusher-a-case-report
#11
Aram Yang, Jinsup Kim, Chang-Seok Ki, Sung Hwa Hong, Sung Yoon Cho, Dong-Kyu Jin
BACKGROUND: Hypoparathyroidism, sensorineural hearing loss, and renal disease (HDR) syndrome, also known as Barakat syndrome, is a rare genetic disorder with high phenotypic heterogeneity caused by haploinsufficiency of the GATA3 gene on chromosome 10p14-p15. For these reasons, the diagnosis of HDR syndrome is challenging and requires a high index of suspicion as well as genetic analysis. CASE PRESENTATION: A 14-month-old boy, with sensorineural hearing loss in both ears, showed typical radiological features of X-linked stapes gusher on preoperative temporal bone computed tomography (CT) for cochlear implantations...
October 26, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28989763/into-the-dark-patterns-of-middle-ear-adaptations-in-subterranean-eulipotyphlan-mammals
#12
Daisuke Koyabu, Misato Hosojima, Hideki Endo
Evolution of the middle ear ossicles was a key innovation for mammals, enhancing the transmission of airborne sound. Radiation into various habitats from a terrestrial environment resulted in diversification of the auditory mechanisms among mammals. However, due to the paucity of phylogenetically controlled investigations, how middle ear traits have diversified with functional specialization remains unclear. In order to identify the respective patterns for various lifestyles and to gain insights into fossil forms, we employed a high-resolution tomography technique and compared the middle ear morphology of eulipotyphlan species (moles, shrews and hedgehogs), a group that has radiated into various environments, such as terrestrial, aquatic and subterranean habitats...
September 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28971731/absence-of-measles-virus-detection-from-stapes-of-patients-with-otosclerosis
#13
María de Lourdes Flores-García, Claudia Adriana Colín-Castro, Mario Sabas Hernández-Palestina, Roberto Sánchez-Larios, Rafael Franco-Cendejas
Objective To determine molecularly the presence of measles virus genetic material in the stapes of patients with otosclerosis. Study Design A cross-sectional study. Setting A tertiary referral hospital. Subjects and Methods Genetic material was extracted from the stapes of patients with otosclerosis (n = 93) during the period from March 2011 to April 2012. The presence of viral measles sequences was evaluated by the real-time reverse transcriptase polymerase chain reaction (RT-PCR). The expression of the CD46 gene was determined...
September 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28953605/risk-factors-of-recurrence-in-pediatric-congenital-cholesteatoma
#14
Yuka Morita, Kuniyuki Takahashi, Shuji Izumi, Yamato Kubota, Shinsuke Ohshima, Yutaka Yamamoto, Sugata Takahashi, Arata Horii
OBJECTIVE: To examine the risk factors of recurrence in pediatric congenital cholesteatoma. STUDY DESIGN: Retrospective chart review. SETTING: University hospital. PATIENTS: Sixty-seven patients having tympanic type of congenital cholesteatoma under 15-years old at surgery. INTERVENTIONS: Canal wall-up tympanomastoidectomy (n = 30) or transcanal atticotomy/tympanoplasty (n = 37) was performed depending on cholesteatoma extension, 16 of which were followed by second-look surgery...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28920722/-comparative-evaluation-of-vertigo-in-patients-after-stapedotomy-and-stapedectomy
#15
Kinga Harmat, Gergely Thurén, László Simon, Nelli Nepp, Adrienn Németh, Imre Gerlinger, Péter Bakó
INTRODUCTION AND AIM: The reason of gradually developing conductive hearing loss in otosclerotic patients is the ossification of the stapes footplate to the surrounding bony structures and the therapy of stapes fixation is mainly surgical. In stapedotomy the footplate of the stapes is fenestrated with laser and microdrill in a diameter of 0.8 mm, whereas in stapedectomy there is complete removal of the footplate followed by the reconstruction of the ossicular chain. In the early postoperative period, temporary vertigo is frequently recorded which significantly influences the recovery...
September 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28895462/is-hospitalization-necessary-after-ear-surgery-a-national-survey-and-retrospective-review-of-postoperative-events
#16
Tanja Jelicic, Julian Richard Savage, Margaret Aron
Objective First, to survey our national otolaryngology colleagues on their postoperative care habits (hospitalization vs day surgery) after elective middle ear surgery. Second, to evaluate the necessity of hospitalization and safety of day surgery after these procedures. Methods A national survey regarding postoperative habits after elective middle ear surgery was launched. Then, the cases of all patients having undergone these surgical procedures at our center between 2010 and 2016 were reviewed. They were divided into 2 groups: hospitalization and day surgery...
October 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28874211/audiological-outcome-of-stapes-surgery-for-far-advanced-cochlear-otosclerosis
#17
C Heining, R Banga, R Irving, C Coulson, P Monksfield
BACKGROUND: Patients with advanced otosclerosis can present with hearing thresholds eligible for cochlear implantation. This study sought to address whether stapes surgery in this patient group provides a clinically significant audiological benefit. OBJECTIVES: To assess pre- and post-operative hearing outcomes of patients with advanced otosclerosis, and to determine what proportion of these patients required further surgery including cochlear implantation. METHODS: Between 2002 and 2015, 252 patients underwent primary stapes surgery at our institution...
September 6, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28872782/erosion-of-the-long-process-of-the-incus-with-incomplete-ossicular-discontinuity-in-simple-chronic-otitis-media-should-we-reconstruct-or-leave-it-be
#18
Krishnamurti Matos Araujo Sarmento Junior, Carlos Augusto Costa Pires de Oliveira, André Luiz Lopes Sampaio, Angelo Ferreira Sales
OBJECTIVE: To determine whether patients with simple chronic otitis media and incomplete ossicular discontinuity should undergo ossicular reconstruction. DESIGN: Prospective, randomized surgical trial comparing no intervention with incus interposition over a 5-year period. SETTING: Tertiary referral hospital. PARTICIPANTS: Seventy-six participants with simple chronic otitis media and erosion of the long process of the incus but apparent good transmission throughout the ossicular chain as tested intraoperatively...
September 5, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28863551/rippling-pattern-of-distortion-product-otoacoustic-emissions-evoked-by-high-frequency-primaries-in-guinea-pigs
#19
George W S Burwood, Ian J Russell, Andrei N Lukashkin
The origin of ripples in distortion product otoacoustic emission (DPOAE) amplitude which appear at specific DPOAE frequencies during f1 tone sweeps using fixed high frequency f2 (>20 kHz) in guinea pigs is investigated. The peaks of the ripples, or local DPOAE amplitude maxima, are separated by approximately half octave intervals and are accompanied by phase oscillations. The local maxima appear at the same frequencies in DPOAEs of different order and velocity responses of the stapes and do not shift with increasing levels of the primaries...
August 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28852952/atlas-based-segmentation-of-temporal-bone-anatomy
#20
Kimerly A Powell, Tong Liang, Brad Hittle, Don Stredney, Thomas Kerwin, Gregory J Wiet
PURPOSE: To develop a time-efficient automated segmentation approach that could identify critical structures in the temporal bone for visual enhancement and use in surgical simulation software. METHODS: An atlas-based segmentation approach was developed to segment the cochlea, ossicles, semicircular canals (SCCs), and facial nerve in normal temporal bone CT images. This approach was tested in images of 26 cadaver bones (13 left, 13 right). The results of the automated segmentation were compared to manual segmentation visually and using DICE metric, average Hausdorff distance, and volume similarity...
November 2017: International Journal of Computer Assisted Radiology and Surgery
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