Denali K Dahl, Ashlyn N Whitesell, Preetika Sharma-Huynh, Panita Maturavongsadit, Rima Janusziewicz, Ryan J Fox, Henry T Loznev, Brian Button, Allison N Schorzman, William Zamboni, Jisun Ban, Stephanie A Montgomery, Erin T Carey, S Rahima Benhabbour
Vestibulodynia (VBD), an idiopathic pain disorder characterized by erythema and pain of the vulvar vestibule (the inner aspect of the labia minora and vaginal opening), is the most common cause of sexual pain for women of reproductive age. Women also feel discomfort with contact with clothing and tampon use. As most women with this disorder only have pain with provocation of the tissue, topical anesthetics applied to the vestibule are the current first line treatment for temporary pain relief. Treatment options are limited due to anatomical constraints of the vestibular region, poor drug retention time, imprecise dosing, leakage, and overall product messiness...
January 25, 2022: International Journal of Pharmaceutics