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https://www.readbyqxmd.com/read/27890833/pulse-wave-analysis-after-treatment-of-abdominal-aortic-aneurysms-with-the-ovation-device
#1
Efstratios Georgakarakos, Christos Argyriou, George S Georgiadis, Miltos K Lazarides
BACKGROUND: Ovation Aortic Stent-Graft System is a new device for the endovascular treatment of Abdominal Aortic Aneurysms achieving fixation via a 35-mm long, rigid ancored suprarenal stent and sealing stent at the infrarenal level by a means of a polymer-filling pair of inflatable O-rings which cause narrowing of flow lumen and regional stenosis. Thus, concerns have been raised regarding hemodynamic consequences associated with this new desing . Our preliminary report showed no significant increase of aortic pulse wave velocity (aPWV) immediately after implantation of the Ovation in 3 patients...
November 24, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27862458/rapid-sample-classification-using-an-open-port-sampling-interface-coupled-with-liquid-introduction-atmospheric-pressure-ionization-mass-spectrometry
#2
Gary J Van Berkel, Vilmos Kertesz
RATIONALE: An "Open Access" - like mass spectrometric platform to fully utilize the simplicity of the manual open port sampling interface for rapid characterization of unprocessed samples by liquid introduction atmospheric pressure ionization mass spectrometry has been lacking. The in-house developed integrated software with a simple, small and relatively low-cost mass spectrometry system introduced here fills this void. METHODS: Software was developed to operate the mass spectrometer, to collect and process mass spectrometric data files, to build a database and to classify samples using such a database...
November 15, 2016: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/27845113/re-conversion-of-urodynamic-pressures-measured-simultaneously-by-air-charged-and-water-filled-catheter-systems
#3
Alan J Wein
No abstract text is available yet for this article.
December 2016: Journal of Urology
https://www.readbyqxmd.com/read/27815052/academic-medical-centers-and-community-hospitals-integration-trends-and-strategies
#4
Howard B Fleishon, Jason N Itri, Giles W Boland, Richard Duszak
Academic medical centers are widely recognized as vital components of the American health care system, generally differentiated from their community hospital peers by their tripartite mission of clinical care, education, and research. Community hospitals fill a critical and complementary role, serving as the primary sites for health care in most communities. Health care reform initiatives and economic pressures have created incentives for hospitals and health systems to integrate, resulting in a nationwide trend toward consolidation with academic medical centers leveraging their substantial assets to merge, acquire, or establish partnerships with their community peers...
November 1, 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27812547/acute-hemodynamic-effects-of-inhaled-sodium-nitrite-in-pulmonary-hypertension-associated-with-heart-failure-with-preserved-ejection-fraction
#5
Marc A Simon, Rebecca R Vanderpool, Mehdi Nouraie, Timothy N Bachman, Pamela M White, Masataka Sugahara, John Gorcsan, Ed L Parsley, Mark T Gladwin
BACKGROUND: Pulmonary hypertension (PH) is associated with poor outcomes, yet specific treatments only exist for a small subset of patients. The most common form of PH is that associated with left heart disease (Group 2), for which there is no approved therapy. Nitrite has shown efficacy in preclinical animal models of Group 1 and 2 PH, as well as in patients with left heart failure with preserved ejection fraction (HFpEF). We evaluated the safety and efficacy of a potentially novel inhaled formulation of nitrite in PH-HFpEF patients as compared with Group 1 and 3 PH...
November 3, 2016: JCI Insight
https://www.readbyqxmd.com/read/27798232/quantifying-dorsal-closure-in-three-dimensions
#6
Heng Lu, Adam Sokolow, Daniel P Kiehart, Glenn S Edwards
Dorsal closure is an essential stage of Drosophila embryogenesis and is a powerful model system for morphogenesis, wound healing, and tissue biomechanics. During closure two flanks of lateral epidermis close an eye-shaped dorsal opening that is filled with amnioserosa. The two flanks of lateral epidermis are zipped together at each canthus ("corner" of the eye). Actomyosin-rich purse strings are localized at each of the two leading edges of lateral epidermis ("lids" of the eye). Here we report that each purse string indents the dorsal surface at each leading edge...
October 26, 2016: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/27787699/the-interplay-between-renin-angiotensin-system-activation-abnormal-myocardial-deformation-and-neurohumoral-activation-in-hypertensive-heart-disease-a-speckle-tracking-echocardiography-study
#7
Ignatios Ikonomidis, Stavros Tzortzis, Argirios Tsantes, Konstantina Ntai, Helen Triantafyllidi, Paraskevi Trivilou, George Katsimaglis, Kleanthi Dima, John Parissis, John Lekakis
Angiotensin converting enzyme (ACE) promotes cardiac fibrosis. LV myocardial deformation and torsion are markers of subclinical myocardial dysfunction. We investigated the association of serum ACE levels with LV deformation markers in untreated hypertensives. In 120 untreated patients (age: 53.5 ± 11.2 years) with essential hypertension and 60 healthy controls, we measured (a) LV longitudinal, circumferential and radial strain (S), peak torsion and the percentage changes between peak twisting and untwisting at the end of early diastolic filling (%dpTw-UtwEDF) using speckle tracking echocardiography and (b) serum levels of ACE and NTproBNP...
October 27, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27783382/short-term-effects-of-neuromuscular-blockade-on-global-and-regional-lung-mechanics-oxygenation-and-ventilation-in-pediatric-acute-hypoxemic-respiratory-failure
#8
Marlon E F Wilsterman, Pauline de Jager, Robert Blokpoel, Inez Frerichs, Sandra K Dijkstra, Marcel J I J Albers, Johannes G M Burgerhof, Dick G Markhorst, Martin C J Kneyber
BACKGROUND: Neuromuscular blockade (NMB) has been shown to improve outcome in acute respiratory distress syndrome (ARDS) in adults, challenging maintaining spontaneous breathing when there is severe lung injury. We tested in a prospective physiological study the hypothesis that continuous administration of NMB agents in mechanically ventilated children with severe acute hypoxemic respiratory failure (AHRF) improves the oxygenation index without a redistribution of tidal volume V T toward non-dependent lung zones...
December 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27782610/development-and-characterization-of-a-high-yield-transportable-pulsed-neutron-source-with-efficient-and-compact-pulsed-power-system
#9
Rishi Verma, Ekansh Mishra, Prosenjit Dhang, Karuna Sagar, Manraj Meena, Anurag Shyam
The results of characterization experiments carried out on a newly developed dense plasma focus device based intense pulsed neutron source with efficient and compact pulsed power system are reported. Its high current sealed pseudospark switch based low inductance capacitor bank with maximum stored energy of ∼10 kJ is segregated into four modules of ∼2.5 kJ each and it cumulatively delivers peak current in the range of 400 kA-600 kA (corresponding to charging voltage range of 14 kV-18 kV) in a quarter time period of ∼2 μs...
September 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27778100/internally-coupled-ears-mathematical-structures-and-mechanisms-underlying-ice
#10
Anupam P Vedurmudi, Bruce A Young, J Leo van Hemmen
In internally coupled ears (ICE), the displacement of one eardrum creates pressure waves that propagate through air-filled passages in the skull, causing a displacement of the opposing eardrum and vice versa. In this review, a thorough mathematical analysis of the membranes, passages, and propagating pressure waves reveals how internally coupled ears generate unique amplitude and temporal cues for sound localization. The magnitudes of both of these cues are directionally dependent. On the basis of the geometry of the interaural cavity and the elastic properties of the two eardrums confining it at both ends, the present paper reviews the mathematical theory underlying hearing through ICE and derives analytical expressions for eardrum vibrations as well as the pressures inside the internal passages, which ultimately lead to the emergence of highly directional hearing cues...
October 25, 2016: Biological Cybernetics
https://www.readbyqxmd.com/read/27773316/a-numerical-model-for-the-study-of-the-difference-frequency-generated-from-nonlinear-mixing-of-standing-ultrasonic-waves-in-bubbly-liquids
#11
María Teresa Tejedor Sastre, Christian Vanhille
The aim of this paper is the study of the behavior of nonlinear standing ultrasonic waves in bubbly liquids and the generation of the difference frequency by nonlinear mixing of several signals. To this end we present a new numerical model based on the finite-volume method and the finite-difference method. This model solves the differential system formed by the wave equation and a Rayleigh-Plesset equation coupling the acoustic pressure field with the bubble vibrations. We consider a resonator filled with a bubbly liquid excited by an ultrasonic pressure source...
January 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/27768204/in-vitro-performance-investigation-of-syncardia%C3%A2-freedom%C3%A2-driver-via-patient-simulator-mock-loop
#12
Riccardo Toninato, Silvia Scuri, Vincenzo Tarzia, Gino Gerosa, Francesca M Susin
PURPOSE: The gold standard therapy for patients with advanced heart failure is heart transplant. The gap between donors and patients in waiting lists promoted the development of circulatory support devices, such as the total artificial heart (TAH). Focusing on in vitro tests performed with CardioWest™ TAH (CW) driven by the SynCardia Freedom® portable driver (FD) the present study goals are: i) prove the reliability of a hydraulic circuit used as patient simulator to replicate a quasi-physiological scenario for various hydrodynamic conditions, ii) investigate the hydrodynamic performance of the CW FD, iii) help clinicians in possible interpretation of clinical cases outcomes...
November 29, 2016: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/27754185/hw-02-3-ambulatory-central-blood-pressure-what-is-the-evidence-for-validation
#13
Thomas Weber
Validation of a medical device measuring a biomarker is a complex process, involving technical aspects (What is actually measured by the device, and how is this done ? Is the measurement reproducible ? Is there a gold standard for measurement of the particular biomarker ? If yes, how accurate and how precise are the measurements by the device, compared to the gold standard ?) and clinical aspects (Do the measurements predict outcome ? If yes, is there added value, when standard clinical parameters are considered ? Is there a treatment strategy, based on the mesurements of the novel device ? Is this strategy cost-effective ?)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754089/os-20-03-the-associations-between-each-component-of-blood-pressure-and-target-organ-damages-in-patients-at-high-risk-of-coronary-artery-disease
#14
Hack-Lyoung Kim, Myung-A Kim, Wan-Joo Shim, Mina Kim, Seong Mi Park, Mi Seung Shin, Kyung-Soon Hong, Yong Hyun Kim, Hyun Ju Yoon, Gil Ja Shin, Kyoung Im Cho
OBJECTIVE: Data from systemic evaluation of the influence of each component of blood pressure (BP) on various target organ damages (TODs) has been limited. This study was performed to elucidate which BP component was associated with TODs in patients with high risk of coronary artery disease (CAD). DESIGN AND METHOD: Study data were obtained from a nation-wide registry, composed of 652 patiens (471 women with 58.4 ± 10.5 year old) with suspected CAD who underwent invasive coronary angiography (CAG)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27683000/auditory-mechanics-in-a-bush-cricket-direct-evidence-of-dual-sound-inputs-in-the-pressure-difference-receiver
#15
Thorin Jonsson, Fernando Montealegre-Z, Carl D Soulsbury, Kate A Robson Brown, Daniel Robert
The ear of the bush-cricket, Copiphora gorgonensis, consists of a system of paired eardrums (tympana) on each foreleg. In these insects, the ear is backed by an air-filled tube, the acoustic trachea (AT), which transfers sound from the prothoracic acoustic spiracle to the internal side of the eardrums. Both surfaces of the eardrums of this auditory system are exposed to sound, making it a directionally sensitive pressure difference receiver. A key feature of the AT is its capacity to reduce the velocity of sound propagation and alter the acoustic driving forces at the tympanum...
September 2016: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/27662701/immediate-dose-response-effect-of-high-energy-versus-low-energy-extracorporeal-shock-wave-therapy-on-cutaneous-microcirculation
#16
Robert Kraemer, Heiko Sorg, Vinzent Forstmeier, Karsten Knobloch, Eirini Liodaki, Felix Hagen Stang, Peter Mailaender, Tobias Kisch
Elucidation of the precise mechanisms and therapeutic options of extracorporeal shock wave therapy (ESWT) is only at the beginning. Although immediate real-time effects of ESWT on cutaneous hemodynamics have recently been described, the dose response to different ESWT energies in cutaneous microcirculation has never been examined. Thirty-nine Sprague-Dawley rats were randomly assigned to three groups that received either focused high-energy shock waves (group A: total of 1000 impulses, 10 J) to the lower leg of the hind limb, focused low-energy shock waves (group B: total of 300 impulses, 1 J) or placebo shock wave treatment (group C: 0 impulses, 0 J) using a multimodality shock wave delivery system (Duolith SD-1 T-Top, Storz Medical, Tägerwilen, Switzerland)...
December 2016: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/27645151/transpulmonary-and-pleural-pressure-in-a-respiratory-system-model-with-an-elastic-recoiling-lung-and-an-expanding-chest-wall
#17
Per Persson, Stefan Lundin, Ola Stenqvist
BACKGROUND: We have shown in acute lung injury patients that lung elastance can be determined by a positive end-expiratory pressure (PEEP) step procedure and proposed that this is explained by the spring-out force of the rib cage off-loading the chest wall from the lung at end-expiration. The aim of this study was to investigate the effect of the expanding chest wall on pleural pressure during PEEP inflation by building a model with an elastic recoiling lung and an expanding chest wall complex...
December 2016: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27643142/hw-02-3-ambulatory-central-blood-pressure-what-is-the-evidence-for-validation
#18
Thomas Weber
Validation of a medical device measuring a biomarker is a complex process, involving technical aspects (What is actually measured by the device, and how is this done ? Is the measurement reproducible ? Is there a gold standard for measurement of the particular biomarker ? If yes, how accurate and how precise are the measurements by the device, compared to the gold standard ?) and clinical aspects (Do the measurements predict outcome ? If yes, is there added value, when standard clinical parameters are considered ? Is there a treatment strategy, based on the mesurements of the novel device ? Is this strategy cost-effective ?)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643014/os-20-03-the-associations-between-each-component-of-blood-pressure-and-target-organ-damages-in-patients-at-high-risk-of-coronary-artery-disease
#19
Hack-Lyoung Kim, Myung-A Kim, Wan-Joo Shim, Mina Kim, Seong Mi Park, Mi Seung Shin, Kyung-Soon Hong, Yong Hyun Kim, Hyun Ju Yoon, Gil Ja Shin, Kyoung Im Cho
OBJECTIVE: Data from systemic evaluation of the influence of each component of blood pressure (BP) on various target organ damages (TODs) has been limited. This study was performed to elucidate which BP component was associated with TODs in patients with high risk of coronary artery disease (CAD). DESIGN AND METHOD: Study data were obtained from a nation-wide registry, composed of 652 patiens (471 women with 58.4 ± 10.5 year old) with suspected CAD who underwent invasive coronary angiography (CAG)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27638238/physiologic-determinants-of-left-atrial-longitudinal-strain-a-two-dimensional-speckle-tracking-and%C3%A2-three-dimensional-echocardiographic-study%C3%A2-in-healthy-volunteers
#20
Marcelo Haertel Miglioranza, Luigi Paolo Badano, Sorina Mihăilă, Diletta Peluso, Umberto Cucchini, Nicola Soriani, Sabino Iliceto, Denisa Muraru
BACKGROUND: Left atrial (LA) longitudinal strain (LS) using two-dimensional speckle-tracking echocardiography has emerged as an important diagnostic and prognostic parameter in various cardiovascular conditions. However, its reference values, their correlations with demographics characteristics, and its physiologic determinants remain to be established. METHODS: Accordingly, 171 healthy volunteers (mean age, 45 ± 12 years; 61% women) in whom LS was obtained from both apical four- and two-chamber dedicated views of the left atrium, considering the P-P interval on the electrocardiogram as the reference cardiac cycle, were prospectively studied...
September 13, 2016: Journal of the American Society of Echocardiography
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