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systemic filling pressure

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https://www.readbyqxmd.com/read/28210935/the-effect-of-fluid-resuscitation-on-the-effective-circulating-volume-in-patients-undergoing-liver-surgery-a-post-hoc-analysis-of-a-randomized-controlled-trial
#1
Jaap Jan Vos, A F Kalmar, H G D Hendriks, J Bakker, T W L Scheeren
To assess the significance of an analogue of the mean systemic filling pressure (Pmsa) and its derived variables, in providing a physiology based discrimination between responders and non-responders to fluid resuscitation during liver surgery. A post-hoc analysis of data from 30 patients undergoing major hepatic surgery was performed. Patients received 15 ml kg(-1) fluid in 30 min. Fluid responsiveness (FR) was defined as an increase of 20% or greater in cardiac index, measured by FloTrac-Vigileo(®). Dynamic preload variables (pulse pressure variation and stroke volume variation: PPV, SVV) were recorded additionally...
February 16, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28208779/proof-of-concept-of-integrated-load-measurement-in-3d-printed-structures
#2
Michaël Hinderdael, Zoé Jardon, Margot Lison, Dieter De Baere, Wim Devesse, Maria Strantza, Patrick Guillaume
Currently, research on structural health monitoring systems is focused on direct integration of the system into a component or structure. The latter results in a so-called smart structure. One example of a smart structure is a component with integrated strain sensing for continuous load monitoring. Additive manufacturing, or 3D printing, now also enables such integration of functions inside components. As a proof-of-concept, the Fused Deposition Modeling (FDM) technique was used to integrate a strain sensing element inside polymer (ABS) tensile test samples...
February 9, 2017: Sensors
https://www.readbyqxmd.com/read/28179257/interplay-between-renal-endothelin-and-purinergic-signaling-systems
#3
Eman Y Gohar, Malgorzata Kasztan, David M Pollock
Alterations in extracellular fluid volume regulation and sodium balance may result in the development and maintenance of salt-dependent hypertension, a major risk factor for cardiovascular disease. Numerous pathways contribute to the regulation of sodium excretion and blood pressure, including endothelin and purinergic signaling. Increasing evidence suggests a link between purinergic receptor activation and endothelin production within the renal collecting duct as a means of promoting natriuresis. A better understanding of the relationship between these two systems, especially in regard to sodium homeostasis, will fill a significant knowledge gap and may provide novel antihypertensive treatment options...
February 8, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28176628/diabetes-type-4-a-paradigm-shift-in-the-understanding-of-glaucoma-the-brain-specific-diabetes-and-the-candidature-of-insulin-as-a-therapeutic-agent
#4
M A Faiq, T Dada
The present analytical anecdote aims at construing the probable mechanism and ensuing applications of the "Brain Diabetes Hypothesis of Glaucoma" proposed by our research group in early 2014. Here we go a step further to look into many important mechanisms that serve to bridge conceptual gaps to fill up the mosaic of a picture revealing that glaucoma indeed is brain specific diabetes and more appropriately "Diabetes Type 4". Based on this conceptual substance, we weave a novel idea of insulin being a potential remedy for glaucoma...
February 6, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/28151871/antihypertensive-medications-and-risk-of-death-and-hospitalizations-in-us-hemodialysis-patients-evidence-from-a-cohort-study-to-inform-hypertension-treatment-practices
#5
Tariq Shafi, Stephen M Sozio, Jason Luly, Karen J Bandeen-Roche, Wendy L St Peter, Patti L Ephraim, Aidan McDermott, Charles A Herzog, Deidra C Crews, Julia J Scialla, Navdeep Tangri, Dana C Miskulin, Wieneke M Michels, Bernard G Jaar, Philip G Zager, Klemens B Meyer, Albert W Wu, L Ebony Boulware
Antihypertensive medications are commonly prescribed to hemodialysis patients but the optimal regimens to prevent morbidity and mortality are unknown. The goal of our study was to compare the association of routinely prescribed antihypertensive regimens with outcomes in US hemodialysis patients.We used 2 datasets for our analysis. Our primary cohort (US Renal Data System [USRDS]) included adult patients initiating in-center hemodialysis from July 1, 2006 to June 30, 2008 (n = 33,005) with follow-up through December 31, 2009...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28134997/mass-transport-circulatory-system-with-emphasis-on-nonendothermic-species
#6
Dane A Crossley, Warren W Burggren, Carl L Reiber, Jordi Altimiras, Kenneth J Rodnick
Mass transport can be generally defined as movement of material matter. The circulatory system then is a biological example given its role in the movement in transporting gases, nutrients, wastes, and chemical signals. Comparative physiology has a long history of providing new insights and advancing our understanding of circulatory mass transport across a wide array of circulatory systems. Here we focus on circulatory function of nonmodel species. Invertebrates possess diverse convection systems; that at the most complex generate pressures and perform at a level comparable to vertebrates...
December 6, 2016: Comprehensive Physiology
https://www.readbyqxmd.com/read/28120447/effects-of-sildenafil-a-phosphodiesterase-type-5-inhibitor-on-the-primary-single-afferent-activity-of-the-rat-bladder
#7
Naoki Aizawa, Hiroki Ito, Rino Sugiyama, Tetsuya Fujimura, Hiroshi Fukuhara, Haruki Kume, Yukio Homma, Yasuhiko Igawa
OBJECTIVES: We investigated the direct effects of sildenafil, a phosphodiesterase type 5 inhibitor, on the single-unit mechanosensitive afferent activities (SAAs) primarily originated from the bladder in the rat. METHODS: Female Sprague-Dawley rats were anesthetized with urethane. SAAs were recorded from the left L6 dorsal roots and classified by conduction velocity as Aδ- or C-fibers. A catheter was inserted into the bladder dome, and a separate catheter was placed in the carotid artery and external iliac vein for monitoring of blood pressure and sildenafil-administration, respectively...
January 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28104899/amino-acid-based-material-for-the-complementary-therapy-of-decubitus-ulcers
#8
Frederico Nogueira, Isabel C Gouveia
Chronic wounds, pressure sores, lesions and infections of microbial origin in bedridden, paralyzed or malnutrition patients remain the object of study of many researchers. There are several intrinsic and extrinsic factors involved in the development of these disorders, which are related to the patient's immune system, making it unable to respond effectively to the treatment of the wound. These factors can be properly controlled, giving particular importance to the ethiology and stage of the wound, as well as the time periods corresponding to the replacement of the dressings...
January 20, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28092926/effect-of-gravity-and-microgravity-on-intracranial-pressure
#9
Justin S Lawley, Lonnie G Petersen, Erin J Howden, Satyam Sarma, William K Cornwell, Rong Zhang, Louis A Whitworth, Michael A Williams, Benjamin D Levine
Astronauts have recently been discovered to have impaired vision, with a presentation that resembles syndromes of elevated intracranial pressure (ICP). This syndrome is considered the most mission critical medical problem identified in the past decade of manned spaceflight. We recruited five men and three women who had an Ommaya reservoir inserted for the delivery of prophylactic central nervous system chemotherapy, but were free of their malignant disease for at least 1 year. ICP was assessed by placing a fluid-filled 25 ga butterfly needle into the Ommaya reservoir...
January 16, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28092417/dense-semi-clathrates-at-high-pressure-a-study-of-the-water-tert-butylamine-system
#10
Rubén Granero-García, Andrzej Falenty, Francesca Paola Anna Fabbiani
In situ high-pressure crystallization and diffraction techniques have been applied to obtain two very structurally-distinct semi-clathrates of the tert-butylamine-water system with hydration numbers 5.65 and 5.8, respectively, thereby considerably reducing a notable hydration gap between the monohydrate and the 7¼-hydrate that results when crystallization space is explored by temperature alone. Both structures can be considered as an intriguing solid-state example of hydrophobic hydration in which the water network creates wide tert-butylamine-filled channels stabilized by cross-linking hydrogen bonds...
January 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28044253/transvenous-inoue-balloon-aortic-valvuloplasty-with-intra-aortic-balloon-pump-in-treating-cardiogenic-shock-due-to-critical-calcific-aortic-stenosis
#11
Yoshihito Sakata
A 90-year-old female with severe peripheral vascular disease developed cardiogenic shock (CS) due to critical aortic stenosis (AS). The balloon aortic valvuloplasty was emergently performed via transvenous and transseptal antegrade approach (ante-BAV), which saved arterial accesses for intra-aortic balloon pump (IABP) and enabled us to use the Inoue balloon. The IABP augmented systemic perfusions and controlled left heart filling pressures. Multiple times of inflations with stepwisely increased balloon diameters were performed under IABP support (ante-Inoue-BAV + IABP), resulting in remarkable improvements both in clinical and hemodynamic conditions...
January 2, 2017: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/28043677/pressure-volume-loop-derived-cardiac-indices-during-dobutamine-stress-a-step-towards-understanding-limitations-in-cardiac-output-in-children-with-hypoplastic-left-heart-syndrome
#12
James Wong, Kuberan Pushparajah, Adelaide de Vecchi, Bram Ruijsink, Gerald F Greil, Tarique Hussain, Reza Razavi
BACKGROUND: Children with a single systemic right ventricle, such as in hypoplastic left heart syndrome (HLHS), frequently experience reduced exercise capacity. Elucidating the causes could help with optimising treatment strategies. METHODS: Prospective data from 10 consecutive symptomatic patients with HLHS undergoing clinical cardiac magnetic resonance with catheterisation (XMR) were analysed. Mean age 8.6years (range 3.5-11.6years), mean time since Fontan completion 5...
March 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28033201/right-ventricular-failure-post-lvad-implantation-corrected-with-biventricular-support-an-in-vitro-model
#13
Sajad Shehab, Sabine M Allida, Patricia M Davidson, Phillip J Newton, Desiree Robson, Paul C Jansz, Christopher S Hayward
Right ventricular failure after left ventricular assist device (LVAD) implantation is associated with high mortality. Management remains limited to pharmacologic therapy and temporary mechanical support. Delayed right ventricular assist device (RVAD) support after LVAD implantation is associated with poorer outcomes. With the advent of miniaturized, durable, continuous flow ventricular assist device systems, chronic RVAD and biventricular assist device (BiVAD) support has been used with some success. The purpose of this study was to assess combined BiVAD and LVAD with delayed RVAD support within a four-elemental mock circulatory loop (MCL) simulating the human cardiovascular system...
January 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28029613/a-mems-condenser-microphone-based-intracochlear-acoustic-receiver
#14
Flurin Pfiffner, Lukas Prochazka, Dominik Peus, Ivo Dobrev, Adrian Dalbert, Jae Hoon Sim, Rahel Kesterke, Joris Walraevens, Francesca Paris, Christof Roosli, Dominik Obrist, A M Huber
GOAL: Intracochlear sound pressure (ICSP) measurements are limited by the small dimensions of the human inner ear and the requirements imposed by the liquid medium. A robust intracochlear acoustic receiver (ICAR) for repeated use with a simple data acquisition system that provides the required high sensitivity and small dimensions does not yet exist. The work described in this report aims to fill this gap and presents a new MEMS condenser microphone (CMIC) based ICAR concept suitable for ICSP measurements in human temporal bones...
December 16, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28026109/soft-elastomers-with-ionic-liquid-filled-cavities-as-strain-isolating-substrates-for-wearable-electronics
#15
Yinji Ma, Matt Pharr, Liang Wang, Jeonghyun Kim, Yuhao Liu, Yeguang Xue, Rui Ning, Xiufeng Wang, Ha Uk Chung, Xue Feng, John A Rogers, Yonggang Huang
Managing the mechanical mismatch between hard semiconductor components and soft biological tissues represents a key challenge in the development of advanced forms of wearable electronic devices. An ultralow modulus material or a liquid that surrounds the electronics and resides in a thin elastomeric shell provides a strain-isolation effect that enhances not only the wearability but also the range of stretchability in suitably designed devices. The results presented here build on these concepts by (1) replacing traditional liquids explored in the past, which have some nonnegligible vapor pressure and finite permeability through the encapsulating elastomers, with ionic liquids to eliminate any possibility for leakage or evaporation, and (2) positioning the liquid between the electronics and the skin, within an enclosed, elastomeric microfluidic space, but not in direct contact with the active elements of the system, to avoid any negative consequences on electronic performance...
December 27, 2016: Small
https://www.readbyqxmd.com/read/28024557/acute-right-ventricle-failure-in-the-intensive-care-unit-assessment-and-management
#16
REVIEW
Carmen Hrymak, Johann Strumpher, Eric Jacobsohn
Caring for the critically ill patient with acute right ventricle (RV) failure is a diagnostic and management challenge. A thorough understanding of normal RV anatomy and physiology is essential to manage RV failure. Despite the fact that the RV is essentially a volume chamber that ejects into a low-pressure system, the left ventricle contributes significantly to RV function through maintenance of the transseptal gradient (TSG). Preserving systemic mean arterial pressure maintains the TSG and RV perfusion. Various pathological states cause acute RV failure by decreasing the TSG and RV perfusion and/or increasing pulmonary vascular resistance...
January 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/27993467/dissolution-kinetics-of-volatile-organic-compound-vapors-in-water-an-integrated-experimental-and-computational-study
#17
Mojtaba G Mahmoodlu, Elizabeth M Pontedeiro, Jesús S Pérez Guerrero, Amir Raoof, S Majid Hassanizadeh, Martinus Th van Genuchten
In this study we performed batch experiments to investigate the dissolution kinetics of trichloroethylene (TCE) and toluene vapors in water at room temperature and atmospheric pressure. The batch systems consisted of a water reservoir and a connected headspace, the latter containing a small glass cylinder filled with pure volatile organic compound (VOC). Results showed that air phase concentrations of both TCE and toluene increased relatively quickly to their maximum values and then became constant. We considered subsequent dissolution into both stirred and unstirred water reservoirs...
January 2017: Journal of Contaminant Hydrology
https://www.readbyqxmd.com/read/27989060/acute-invasive-hemodynamic-effects-of-transcatheter-aortic-valve-replacement
#18
Michael Chrissoheris, Antonis Ziakas, Antonis Chalapas, Stavros Chadjimiltiades, Ioannis Styliades, Charalambos Karvounis, Ioulia Nikolaou, Konstantinos Spargias
BACKGROUND: Aortic stenosis imposes a chronic pressure overload on the left ventricle, with attendant adaptations in hemodynamics, muscle mass and performance. The hemodynamic changes that occur during the initial 24 h following abrupt removal of the impediment to left ventricular outflow have not been previously examined. METHODS: A total of 52 patients with right heart catheterization was evaluated before, within 6 h and at 24 h after successful transcatheter aortic valve replacement (TAVR)...
March 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/27979984/haemodynamic-response-to-muscle-reflex-is-abnormal-in-patients-with-heart-failure-with-preserved-ejection-fraction
#19
Silvana Roberto, Gabriele Mulliri, Raffaele Milia, Roberto Solinas, Virginia Pinna, Gianmarco Sainas, Massimo F Piepoli, Antonio Crisafulli
The aim of the present investigation was to assess the role of cardiac diastole on the hemodynamic response to metaboreflex activation. We wanted to determine whether patients with diastolic function impairment showed a different hemodynamic response as compared to normal subjects during this reflex. Hemodynamics during the metaboreflex activation obtained by post-exercise muscle ischemia (PEMI) was assessed in 10 patients with diagnosed heart failure with preserved ejection fraction (HFpEF) and in 12 age-matched healthy controls (CTL)...
December 15, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27974654/water-relations-in-tree-physiology-where-to-from-here
#20
REVIEW
Joe Landsberg, Richard Waring
We look back over 50 years of research into the water relations of trees, with the objective of assessing the maturity of the topic in terms of the idea of a paradigm, put forward by Kuhn in 1962. Our brief review indicates that the physical processes underlying the calculation of transpiration are well understood and accepted, and knowledge of those processes can be applied if information about the leaf area of trees, and stomatal conductance, is available. Considerable progress has been made in understanding the factors governing stomatal responses to environment, with insights into how the hydraulic conducting system of trees determines the maximum aperture of stomata...
December 14, 2016: Tree Physiology
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