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systemic filling pressure

Milton Packer, Dalane W Kitzman
Obesity-related heart failure with a preserved ejection fraction (HFpEF) is an important phenotype prevalent in the community, especially in people with metabolic disorders (e.g., dyslipidemia, diabetes). These individuals exhibit a marked expansion of plasma volume, but ventricular distensibility is limited, most likely as a result of cardiac microvascular rarefaction acting in concert with myocardial and pericardial fibrosis. Consequently, the increase in plasma volume causes a disproportionate increase in cardiac filling pressures, leading to heart failure, even though systolic ejection is not impaired...
March 7, 2018: JACC. Heart Failure
Yiwen Wang, Jürgen Berger, Bernard Moussian
Terminal differentiation of an organ is the last step in development that enables the organism to survive in the outside world after birth. Terminal differentiation of the insect tracheae that ends with filling the tubular network with gas is not fully understood at the tissue level. Here, we demonstrate that yet unidentified valves at the end of the tracheal system of the fruit fly Drosophila melanogaster embryo are important elements allowing terminal differentiation of this organ. Formation of these valves depends on the function of the zona pellucida protein Trynity (Tyn)...
March 5, 2018: Developmental Biology
R W Liefferink, A Naillon, D Bonn, M Prat, N Shahidzadeh
The behaviour of minerals (i.e. salts) such as sodium chloride and calcite in porous media is very important in various applications such as weathering of artworks, oil recovery and CO2 sequestration. We report a novel method for manufacturing single layer porous media in which minerals can be entrapped in a controlled way in order to study their dissolution and recrystallization. In addition, our manufacturing method is a versatile tool for creating monomodal, bimodal or multimodal pore size microporous media with controlled porosity ranging from 25% to 50%...
March 5, 2018: Lab on a Chip
Martin Kluckow
Assessment and treatment of the VLBW infant with cardiovascular impairment requires understanding of the underlying physiology of the infant in transition. The situation is dynamic with changes occurring in systemic blood pressure, pulmonary pressures, myocardial function, and ductal shunt in the first postnatal days. New insights into the role of umbilical cord clamping in the transitional circulation have been provided by large clinical trials of early versus later cord clamping and a series of basic science reports describing the physiology in an animal model...
2018: Frontiers in Pediatrics
Minxuan Xu, Junjie Qi, Feng Li, Yue Zhang
Strain sensors with high sensitivity, broad sensing ranges and excellent durable stability are highly desirable due to their promising potential in electronic skins and human-friendly wearable interactive systems. Herein, we report a high-performance strain sensor based on rGO (reduced graphene oxide)/DI (deionized water) sensing elements. The strain sensors were fabricated by using Ecoflex rubber filled with rGO/DI conductive liquids via template methods, making the process simple, low-cost and scalable. The as-assembled strain sensors can be used to reflect both stretching and compressing with high sensitivity (a maximum gauge factor of 31...
March 2, 2018: Nanoscale
Y X Gao, Y T Liu, Y Y Zhang, J J Qiu, T T Zhao, C A Yu, J G Zheng
Objective: To establish the mouse aorta dissection (AD) model through drinking water containing β-aminopropionitrile (BAPN). Methods: Forty 3-week-old C57B1/6J male mice were divided into four groups according to randomized block design: control, 0.2, 0.4 and 0.8 g·kg(-1)·d(-1) BAPN groups (dissolving respective dose of BAPN in the drinking water, n= 10 each group). Arterial systolic blood pressure and heart rate were measured weekly in conscious, restrained mice using a noninvasive computerized tail-cuff system...
February 24, 2018: Zhonghua Xin Xue Guan Bing za Zhi
Lucia Maria Costa Monteiro, Glaura Nisya de Oliveira Cruz, Juliana Marin Fontes, Tania Regina Dias Saad Salles, Marcia Cristina Bastos Boechat, Ana Carolina Monteiro, Maria Elizabeth Lopes Moreira
INTRODUCTION: Congenital Zika Syndrome (CZS) has been associated with microcephaly and other central nervous system abnormalities including areas that have been implicated in the control of the lower urinary tract. As such, this descriptive case series has aimed to investigate whether CZS is linked with neurogenic bladder. Identifying such an association is paramount in the effort to recognize CZS complications that have putative treatment options that could mitigate the impact of CZS in infected children...
2018: PloS One
Brian Y Chang, Steven P Keller, Sonya S Bhavsar, Noam Josephy, Elazer R Edelman
The full potential of mechanical circulatory systems in the treatment of cardiogenic shock is impeded by the lack of accurate measures of cardiac function to guide clinicians in determining when to initiate and how to optimally titrate support. The left ventricular end diastolic pressure (LVEDP) is an established metric of cardiac function that refers to the pressure in the left ventricle at the end of ventricular filling and immediately before ventricular contraction. In clinical practice, LVEDP is typically only inferred from, and poorly correlates with, the pulmonary capillary wedge pressure (PCWP)...
February 28, 2018: Science Translational Medicine
Darlene M Dreon, Trevor M Hannon, Brett Cross, Brett J Carter, Nicholas S Mercer, Jason H Nguyen, Andy Tran, Peter A Melendez, Nancy Morales, Jonathan E Nelson, Meng H Tan
BACKGROUND: A basal bolus insulin regimen requires multiple daily insulin injections, which might discourage patient adherence. As a potential solution, a mealtime insulin-delivery system-a 3-day wearable bolus-only patch-was designed to manually administer mealtime insulin discreetly by actuating buttons through clothing, without the need for multiple needle sticks. METHOD: Extensive functional testing of the patch included dose accuracy (from initial fill of the device to empty), pressure-vacuum leak testing, last-dose lockout and occlusion detection (safety alert features that lock the dosing buttons when no insulin is delivered), assessments of insulin drug stability, toxicological risk (including chemical testing), and system biocompatibility...
February 1, 2018: Journal of Diabetes Science and Technology
C Liang, K-Y Wang, M-R Gong, Q Li, Z Yu, B Xu
BACKGROUND: On the basis of the importance of the enteric nervous system (ENS) in gastrointestinal motility, we hypothesized that the ENS may mediate the therapeutic efficacy of electro-acupuncture (EA) in constipation by regulating the mechanisms underlying the effects of EA on gastrointestinal function. METHODS: Model mice with constipation were generated by gastric instillation of 0-4°C normal saline. Defecation time and stool (form and wet and dry weight) were assessed...
February 28, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Xu Hou, Jianyu Li, Alexander B Tesler, Yuxing Yao, Miao Wang, Lingli Min, Zhizhi Sheng, Joanna Aizenberg
Microscale flows of fluids are mainly guided either by solid matrices or by liquid-liquid interfaces. However, the solid matrices are plagued with persistent fouling problems, while liquid-liquid interfaces are limited to low-pressure applications. Here we report a dynamic liquid/solid/gas material containing both air and liquid pockets, which are formed by partially infiltrating a porous matrix with a functional liquid. Using detailed theoretical and experimental data, we show that the distribution of the air- and liquid-filled pores is responsive to pressure and enables the formation and instantaneous recovery of stable liquid-liquid interfaces that sustain a wide range of pressures and prevent channel contamination...
February 21, 2018: Nature Communications
Honoka Fujii, Sachiko Horie, Kazu Takeda, Shiro Mori, Tetsuya Kodama
The lymphatic drug delivery system (LDDS) is a new technique that permits the injection of drugs into a sentinel lymph node (SLN) at an early stage of tumor metastasis, thereby treating metastasis in the SLN and its secondary lymph nodes (LNs). The quantity of drug required for a LDDS is much smaller than that needed for systemic chemotherapy. However, the relationship between the rate of drug injection into a SLN and the amount of drug reaching the secondary LNs has not been investigated. In this study, we used an MXH10/Mo-lpr/lpr mouse model to show that the optimal rate for the injection of a fluorescent dye by a LDDS was 10-80 μL/min...
February 20, 2018: Journal of Biophotonics
Sungki Min, Taekyeong Lee, Soon Hyuck Lee, Junghwa Hong
A new theoretical generation mechanism of the transient streaming potential considering variations in the surface potential on the wall in a lacunocanalicular system, is proposed based on the assumption of the piezoelectric bone matrix. To obtain the streaming potential analytically, a modified transient charge density equation is proposed. An osteon is modeled as a piezoelectric solid phase having fluid-filled cavities (lacunae) connected by channels (canaliculae) to obtain the pressure gradients in the canaliculae and the electric boundary conditions on the canalicular walls...
February 20, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
M De Bardi, R Müller, C Grünzweig, D Mannes, M Rigollet, F Bamberg, T A Jung, K Yang
Staked-in needle pre-fillable syringes (SIN-PFS) are a convenient delivery system widely established in the growing pharmaceutical market. Under specific storage conditions, the needle of PFS containing high concentration drug product (DP) solution is prone to clogging, which prevents administration of the liquid. The purpose of this study is to clarify the clogging phenomenon of SIN-PFS and to elucidate the role of water vapor transmission via the needle shield. The presence of liquid within needles is a prerequisite condition for clogging and was investigated non-invasively by neutron imaging (NI) to confirm that liquid can migrate into the needle under certain processing conditions...
February 12, 2018: European Journal of Pharmaceutics and Biopharmaceutics
Michael A Maloney, Ian Renshaw, Jonathon Headrick, David T Martin, Damian Farrow
Enhancing practice design is critical to facilitate transfer of learning. Considerable research has focused on the role of perceptual information in practice simulation, yet has neglected how affect and cognition are shaped by practice environments and whether this influences the fidelity of behavior (Headrick et al., 2015). This study filled this gap by examining the fidelity of individual (cognition, affect, and actions) and interpersonal behavior of 10 highly skilled Australian Taekwondo athletes fighting in training compared to competition...
2018: Frontiers in Psychology
Dori E Rosenberg, Amy K Lee, Melissa Anderson, Anne Renz, Theresa E Matson, Jacqueline Kerr, David Arterburn, Jennifer B McClure
BACKGROUND: Older adults have high rates of obesity and are prone to chronic health conditions. These conditions are in part due to high rates of sedentary time (ST). As such, reducing ST could be an innovative strategy for improving health outcomes among obese older adults. To test this theory, we developed a novel, technology-enhanced intervention to reduce sitting time (I-STAND) and pilot tested it to assess the feasibility, acceptability, and preliminary effects of the intervention on ST and biometric outcomes...
February 12, 2018: JMIR Research Protocols
Magalie Ladouceur, Stephanie Baron, Valérie Nivet-Antoine, Gérard Maruani, Gilles Soulat, Helena Pereira, Anne Blanchard, Pierre Boutouyrie, Jean Louis Paul, Elie Mousseaux
BACKGROUND: Heart failure is a serious event in patients with transposition of the great arteries (D-TGA) after atrial redirection surgery. We aimed to determine the association between myocardial fibrosis and systolic and diastolic systemic right ventricle (sRV) dysfunction. METHODS: Diastolic and systolic function of sRV was prospectively assessed using echocardiography and cardiac magnetic resonance imaging (CMR) in 48 patients with atrially switched D-TGA and 26 healthy subjects...
January 31, 2018: International Journal of Cardiology
Loris Pagano, Caterina Pizzutelli, Maria Maddalena Matarazzo, Gaia Monteleone, Damiano Pizzuti
Migration and the current European socioeconomic conditions necessitate an evaluation/assessment, as detailed as possible, of the spread of seasonal infectious diseases in order to reduce inequalities in the healthcare system. The "Scuola di Formazione in Medicina Generale" of Lazio, in collaboration with the Community of Sant'Egidio of Rome, organized an influenza/flu vaccination campaign for homeless people, migrants and the poor in order to check their health conditions and prevent the spread of the most common infectious diseases...
September 2017: Igiene e Sanità Pubblica
Isabel S Bazan, Kofi A Mensah, Anastasiia A Rudkovskaia, Percy K Adonteng-Boateng, Erica L Herzog, Lenore Buckley, Wassim H Fares
Pulmonary hypertension (PH) is a clinical syndrome that is subdivided into five groups per the World Health Organization (WHO) classification, based largely on hemodynamic and pathophysiologic criteria. WHO Group 1 PH, termed pulmonary arterial hypertension (PAH), is a clinically progressive disease that can eventually lead to right heart failure and death, and it is hemodynamically characterized by pre-capillary PH and increased pulmonary vascular resistance in the absence of elevated left ventricular filling pressures...
January 2018: Respiratory Medicine
Hissah Al Abdulsalam, Abdullah A Alatar, Sherif Elwatidy
BACKGROUND: Perivascular spaces (PVS) or Virchow-Robin spaces (VRS) are pial-lined, interstitial fluid-filled structures in the brain that accompany cerebral vessels as they penetrate the cerebral substance. In healthy individuals, a PVS diameter of less than 2 mm is considered normal and can typically be seen within the white matter on magnetic resonance imaging (MRI). When PVS dilate, they are considered benign lesions and are found to be associated with aging and other risk factors...
January 27, 2018: World Neurosurgery
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