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https://www.readbyqxmd.com/read/28795037/unusual-presentation-of-a-penetrating-aortic-arch-injury
#1
Fikret Sami Vural, Atul Kumar Patel, Kashif Mustafa
A 27-year-old man was admitted with a penetrating injury at the mid-manubrium. Computed tomographic (CT) angiography showed a filling defect in the aortic arch. This was evaluated as a sign of injury and the patient underwent an emergency operation. No active bleeding or clot was found in the mediastinum during the operation. The laceration point was between the innominate and the left carotid artery posteriorly. The injury was approached using hypothermic circulatory arrest. Aortotomy and exploration showed a 2-cm-long full-thickness aortic injury with an overlying clot...
August 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28794814/a-new-microfluidic-device-design-for-a-defined-positioning-of-neurons-in-vitro
#2
Katharina Walczuch, Peter Renze, Claudia Ingensiep, Rudolf Degen, Thanh Phong Bui, Uwe Schnakenberg, Peter Bräunig, Katrin Bui-Göbbels
A new triangle-shaped microfluidic channel system for defined cell trapping is presented. Different variants of the same basic geometry were produced to reveal the best fitting parameter combinations regarding efficiency and sensitivity. Variants with differences in the trap gap width and the inter-trap distance were analyzed in detail by Computational Fluid Dynamics simulations and in experiments with artificial beads of different sizes (30, 60, 80 μm). Simulation analysis of flow dynamics and pressure profiles revealed strongly reduced pressure conditions and balanced flow rates inside the microfluidic channels compared to commonly used systems with meandering channels...
July 2017: Biomicrofluidics
https://www.readbyqxmd.com/read/28777197/elabela-improves-cardio-renal-outcome-in-fatal-experimental-septic-shock
#3
David Coquerel, Frédéric Chagnon, Xavier Sainsily, Lauralyne Dumont, Alexandre Murza, Jérôme Côté, Robert Dumaine, Philippe Sarret, Éric Marsault, Dany Salvail, Mannix Auger-Messier, Olivier Lesur
OBJECTIVES: Apelin-13 was recently proposed as an alternative to the recommended β-adrenergic drugs for supporting endotoxin-induced myocardial dysfunction. Since Apelin-13 signals through its receptor (Apelin peptide jejunum) to exert singular inotropic/vasotropic actions and to optimize body fluid balance, this candidate pathway might benefit septic shock management. Whether the newly discovered ELABELA (ELA), a second endogenous ligand of the Apelin peptide jejunum receptor highly expressed in the kidney, further improves cardio-renal impairment remains unknown...
August 2, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28773834/the-shear-mechanisms-of-natural-fractures-during-the-hydraulic-stimulation-of-shale-gas-reservoirs
#4
Zhaobin Zhang, Xiao Li
The shearing of natural fractures is important in the permeability enhancement of shale gas reservoirs during hydraulic fracturing treatment. In this work, the shearing mechanisms of natural fractures are analyzed using a newly proposed numerical model based on the displacement discontinuities method. The fluid-rock coupling system of the model is carefully designed to calculate the shearing of fractures. Both a single fracture and a complex fracture network are used to investigate the shear mechanisms. The investigation based on a single fracture shows that the non-ignorable shearing length of a natural fracture could be formed before the natural fracture is filled by pressurized fluid...
August 23, 2016: Materials
https://www.readbyqxmd.com/read/28771853/kinetic-studies-of-formic-acid-dehydrogenation-catalyzed-by-an-iridium-complex-towards-insights-into-the-catalytic-mechanism-of-high-pressure-hydrogen-gas-production
#5
Masayuki Iguchi, Heng Zhong, Yuichiro Himeda, Hajime Kawanami
The kinetic studies of the catalytic reaction mechanism of the formic acid (FA) dehydrogenation were investigated in presence of the water-soluble iridium complex having 4,4'-dihydroxy-2,2'-bipyridine ligand. Kinetic isotope effect experiments revealed the shift of the rate-limiting step at the low and high concentrations of FA can be caused by the pH dependence of the reaction steps. The proposed equation of reaction rate corresponds well the experimental results about the shift phenomena. Towards an industrial application in future hydrogen fuel filling stations, we will be able to design the dehydrogenation system catalyzed by the iridium complex...
August 3, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28763564/the-accuracy-of-static-pressure-measurement-with-water-filled-urodynamic-systems
#6
Andrew Gammie
AIMS: To quantify the inaccuracy of pressure measurement by water-filled systems, with a view to recommending better practice. METHODS: Papers examining quality of measurements were reviewed, and standards documents examined. Technical data from manufacturers were gathered and summarized. Measurements were made on two different urodynamic systems. Individual inaccuracies were combined using the root sum of squares method. RESULTS: The total inaccuracy in measurement may reach up to 9...
August 1, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28761137/a-4d-view-on-the-evolution-of-metamorphic-dehydration-reactions
#7
John Bedford, Florian Fusseis, Henri Leclère, John Wheeler, Daniel Faulkner
Metamorphic reactions influence the evolution of the Earth's crust in a range of tectonic settings. For example hydrous mineral dehydration in a subducting slab can produce fluid overpressures which may trigger seismicity. During reaction the mechanisms of chemical transport, including water expulsion, will dictate the rate of transformation and hence the evolution of physical properties such as fluid pressure. Despite the importance of such processes, direct observation of mineral changes due to chemical transport during metamorphism has been previously impossible both in nature and in experiment...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28758986/development-of-wearable-sheet-type-shear-force-sensor-and-measurement-system-that-is-insusceptible-to-temperature-and-pressure
#8
Shigeru Toyama, Yasuhiro Tanaka, Satoshi Shirogane, Takashi Nakamura, Tokio Umino, Ryo Uehara, Takuma Okamoto, Hiroshi Igarashi
A sheet-type shear force sensor and a measurement system for the sensor were developed. The sensor has an original structure where a liquid electrolyte is filled in a space composed of two electrode-patterned polymer films and an elastic rubber ring. When a shear force is applied on the surface of the sensor, the two electrode-patterned films mutually move so that the distance between the internal electrodes of the sensor changes, resulting in current increase or decrease between the electrodes. Therefore, the shear force can be calculated by monitoring the current between the electrodes...
July 31, 2017: Sensors
https://www.readbyqxmd.com/read/28748720/blunting-of-cardioprotective-actions-of-estrogen-in-female-rodent-heart-linked-to-altered-expression-of-cardiac-tissue-chymase-and-ace2
#9
Jacqueline S da Silva, Daniele Gabriel-Costa, Hao Wang, Sarfaraz Ahmad, Xuming Sun, Jasmina Varagic, Roberto T Sudo, Carlos M Ferrario, Louis J Dell Italia, Gisele-Zapata Sudo, Leanne Groban
BACKGROUND: Diastolic dysfunction develops in response to hypertension and estrogen (E2) loss and is a forerunner to heart failure (HF) in women. The cardiac renin-angiotensin system (RAS) contributes to diastolic dysfunction, but its role with respect to E2 and blood pressure remain unclear. METHODS: We compared the effects of ovariectomy (OVX) or sham surgery on the cardiac RAS, left ventricular (LV) structure/function, and systemic/intracardiac pressures of spontaneously hypertensive rats (SHRs: n = 6 intact and 6 OVX) and age-matched Wistar-Kyoto (WKY: n = 5 intact and 4 OVX) controls...
July 2017: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/28727805/turgor-responsive-starch-phosphorylation-in-oryza-sativa-stems-a-primary-event-of-starch-degradation-associated-with-grain-filling-ability
#10
Hiroshi Wada, Chisato Masumoto-Kubo, Koichi Tsutsumi, Hiroshi Nonami, Fukuyo Tanaka, Haruka Okada, Rosa Erra-Balsells, Kenzo Hiraoka, Taiken Nakashima, Makoto Hakata, Satoshi Morita
Grain filling ability is mainly affected by the translocation of carbohydrates generated from temporarily stored stem starch in most field crops including rice (Oryza sativa L.). The partitioning of non-structural stem carbohydrates has been recognized as an important trait for raising the yield ceiling, yet we still do not fully understand how carbohydrate partitioning occurs in the stems. In this study, two rice subspecies that exhibit different patterns of non-structural stem carbohydrates partitioning, a japonica-dominant cultivar, Momiroman, and an indica-dominant cultivar, Hokuriku 193, were used as the model system to study the relationship between turgor pressure and metabolic regulation of non-structural stem carbohydrates, by combining the water status measurement with gene expression analysis and a dynamic prefixed 13C tracer analysis using a mass spectrometer...
2017: PloS One
https://www.readbyqxmd.com/read/28719986/three-dimensional-printing-of-surgical-clips-an-in-vitro-pilot-study-and-trial-of-efficacy
#11
Noah E Canvasser, Shuvro De, Ersin Koseoglu, Aaron H Lay, Igor Sorokin, Raul Fernandez, Jeffrey A Cadeddu
Introduction and Objective Three-dimensional printing applications have increased over the past decade. Our objective was to test rapid prototyping of a 3D printed surgical clip for intraoperative use. Methods Our prototype was modeled after the 10mm Weck® Hem-o-lok® polymer clip (Teleflex Inc., Wayne, PA, USA). A 3D computer-aided design model of the Hem-o-lok® clip was reverse-engineered using commercial microscopy and printing was done using an Objet Connex500 multi-jetting system (Stratasys, Eden Prairie, MN, USA)...
July 18, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28719378/chemical-stability-of-morphine-ropivacaine-and-ziconotide-in-combination-for-intrathecal-analgesia
#12
Julien Robert, Jérémy Sorrieul, Elsa Rossignol, Hélène Beaussart, Hélène Kieffer, Caroline Folliard, Denis Dupoiron, Catherine Devys
Pain is the most feared symptom amongst individuals living with cancer. In 15% to 20% of patients, conventional analgesic therapy either fails to relieve pain or induces adverse effects. Intrathecal drug delivery systems may present an effective alternative for pain management. The Cancerology Center Paul Papin protocol includes an admixture of morphine, ropivacaine, and ziconotide in intrathecal preparations. These drugs are administered by a fully implantable or an external pump. Syringes or polyolefin infusion bags are prepared for refill just before use...
July 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28708679/transpulmonary-pressure-describes-lung-morphology-during-decremental-positive-end-expiratory-pressure-trials-in-obesity
#13
Jacopo Fumagalli, Lorenzo Berra, Changsheng Zhang, Massimiliano Pirrone, Roberta R De Santis Santiago, Susimeire Gomes, Federico Magni, Glaucia A B Dos Santos, Desmond Bennett, Vinicius Torsani, Daniel Fisher, Caio Morais, Marcelo B P Amato, Robert M Kacmarek
OBJECTIVES: Atelectasis develops in critically ill obese patients when undergoing mechanical ventilation due to increased pleural pressure. The current study aimed to determine the relationship between transpulmonary pressure, lung mechanics, and lung morphology and to quantify the benefits of a decremental positive end-expiratory pressure trial preceded by a recruitment maneuver. DESIGN: Prospective, crossover, nonrandomized interventional study. SETTING: Medical and Surgical Intensive Care Units at Massachusetts General Hospital (Boston, MA) and University Animal Research Laboratory (São Paulo, Brazil)...
August 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28704259/systemic-blood-pressure-at-exercise-in-hypoxia-in-hypertensive-and-normotensive-patients
#14
Laurent Winkler, François J Lhuissier, Jean-Paul Richalet
OBJECTIVES: The current study aimed to determine whether acute hypoxia exposure in laboratory conditions associated with exercise induces an increase in systemic blood pressure (BP) in normotensive and hypertensive patients, and whether hypertensive patients are more prone to develop severe acute mountain sickness (sAMS). Finally, to determine if BP changes at exercise in acute hypoxia in hypertensive patients are predictive factors for sAMS. METHODS: From 2012 to 2015, 852 normotensive and 106 hypertensive patients went through an acute hypoxia exercise test before a sojourn at high altitude...
July 12, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28702633/a-dft-study-of-h-dissolution-into-the-bulk-of-a-crystalline-ni-111-surface-a-chemical-identifier-for-the-reaction-kinetics
#15
Mahdi Shirazi, Annemie Bogaerts, Erik C Neyts
In this study, we investigated the diffusion of H-atoms to the subsurface and their further diffusion into the bulk of a Ni(111) crystal by means of density functional theory calculations in the context of thermal and plasma-assisted catalysis. The H-atoms at the surface can originate from the dissociative adsorption of H2 or CH4 molecules, determining the surface H-coverage. When a threshold H-coverage is passed, corresponding to 1.00 ML for the crystalline Ni(111) surface, the surface-bound H-atoms start to diffuse to the subsurface...
July 26, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28695343/posterior-colporrhaphy-does-not-affect-the-urethral-closure-mechanism
#16
Yasmine Khayyami, Gunnar Lose, Niels Klarskov
INTRODUCTION AND HYPOTHESIS: Studies have suggested that a posterior vaginal wall prolapse might compress the urethra and mask stress urinary incontinence (SUI), much like an anterior vaginal wall prolapse. A recent study with urethral pressure reflectometry (UPR) has shown that the urethral closure mechanism deteriorates after anterior colporrhaphy; this could explain the occurrence of postoperative de novo SUI. We hypothesized that urethral pressure would also decrease after posterior colporrhaphy...
July 10, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28683651/arthroscopic-airbrush-assisted-cell-spraying-for-cartilage-repair-design-development-and-characterization-of-custom-made-arthroscopic-spray-nozzles
#17
Koen Dijkstra, Jan Hendriks, Marcel Karperien, Lucienne A Vonk, Daniel B Saris
INTRODUCTION: Airbrush-assisted cell spraying would facilitate fully arthroscopic filling of cartilage defects, thereby providing a minimally invasive procedure for cartilage repair. This study provides the development and characterisation of custom-made spray nozzles that could serve as a foundation for the development of a BioAirbrush, a platform technology for the arthroscopic application of (cell-laden) hydrogels. METHODS: Custom-made spray nozzles were designed and produced with 3D printing technology...
July 6, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28683486/-role-of-intraoperative-indirect-channelography-in-glaucoma-stent-implantation
#18
Christopher Wirbelauer, Charlotte Nora Mertens
Several glaucoma stents are available to surgically reduce the intraocular pressure in primary open-angle glaucoma (POAG). In comparison to conjunctival opening procedures, the advantages of microinvasive glaucoma surgery (MIGS) are relatively atraumatic ab-interno procedures through a paracentesis, conjunctival sparing for later filtrating surgery, and possible combined cataract surgery. In this overview, the principle of intraoperative indirect channelography as a decision criterion for the individual selection of glaucoma stent implantation is presented...
July 6, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28679681/acute-effects-of-angiotensin-converting-enzyme-inhibition-versus-angiotensin-ii-receptor-blockade-on-cardiac-sympathetic-activity-in-patients-with-heart-failure
#19
Eduardo R Azevedo, Susanna Mak, John S Floras, John D Parker
The beneficial effects of angiotensin converting enzyme (ACE) inhibitors and angiotensin II (AII) receptor antagonists in patients with heart failure secondary to reduced ejection fraction (HFrEF) are felt to result from prevention of the adverse effects of AII on systemic afterload and renal homeostasis. However, AII can activate the sympathetic nervous system and part of the beneficial effects of ACE inhibitors and AII antagonists may result from their ability to inhibit such activation. We examined the acute effects of the ACE inhibitor captopril (25 mg, n = 9) and the AII receptor antagonist losartan (50 mg, n = 10) on hemodynamics as well as total body and cardiac norepinephrine spillover in patients with chronic HFrEF...
July 5, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28679680/chronic-hypoxia-alters-maternal-uterine-and-fetal-hemodynamics-in-the-term-pregnant-guinea-pig
#20
Shifa Turan, Graham W Aberdeen, Loren P Thompson
Placental hypoxia is associated with maternal hypertension, placental insufficiency and fetal growth restriction. In the pregnant guinea pig, prenatal hypoxia during early gestation inhibits cytotrophoblast invasion of spiral arteries, increases maternal blood pressure and induces fetal growth restriction. This study evaluated the impact of chronic maternal hypoxia on fetal heart structure with 4D echocardiography with spatio-temporal image correlation and tomographic ultrasound (STIC-TUI) and uterine and umbilical artery resistance/pulsatility indices and fetal heart function using pulsed wave Doppler ultrasound...
July 5, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
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