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https://www.readbyqxmd.com/read/28107436/a-micro-ct-study-in-patients-with-breast-microcalcifications-using-a-mathematical-algorithm-to-assess-3d-structure
#1
David Kenkel, Zsuzsanna Varga, Heike Heuer, Konstantin J Dedes, Nicole Berger, Lukas Filli, Andreas Boss
PURPOSE: The aim of this study was to evaluate the relevance of the three-dimensional (3D) structure of breast microcalcifications (MC) as a predictor of malignancy using highly resolved micro-computed tomography (micro-CT) datasets of biopsy samples. MATERIAL AND METHODS: The study included 28 women with suspicious MC in their mammogram undergoing vacuum-assisted biopsy. Directly after the intervention, the specimens were scanned in a micro-CT with an isometric spatial resolution of 9 μm...
2017: PloS One
https://www.readbyqxmd.com/read/28041733/glucose-requirements-of-an-activated-immune-system-in-lactating-holstein-cows
#2
S K Kvidera, E A Horst, M Abuajamieh, E J Mayorga, M V Sanz Fernandez, L H Baumgard
Accurately quantifying activated immune system energy requirements in vivo is difficult, but a better understanding may advance strategies to maximize animal productivity. Study objectives were to estimate whole-body glucose utilization following an i.v. endotoxin challenge. Lactating Holstein cows were jugular catheterized and assigned 1 of 3 bolus treatments: control (CON; 5 mL of saline; n = 6), lipopolysaccharide (LPS)-administered (LPS-C; 1.5 μg/kg of body weight; Escherichia coli 055:B5; n = 6), and LPS + euglycemic clamp (LPS-Eu; 1...
December 29, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/28031266/chronic-plasmodium-chabaudi-infection-generates-cd4-memory-t-cells-with-increased-tcr-sensitivity-but-poor-secondary-expansion-and-increased-apoptosis
#3
Michael M Opata, Robin Stephens
Exposure to blood-stage malaria infection in endemic areas is persistent, leading to generation of CD4 effector and effector memory T cells that contribute to protection. We showed previously that chronic exposure to blood-stage Plasmodium chabaudi maintains the best protection from parasitemia and pathology in re-infection, correlating with an increase in Th1 cells. While much is known about the features of resting or exhausted memory T cells, little is known about the functional capacities of chronically stimulated, but protective T cells...
December 28, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/28027470/performance-of-a-novel-atrazine-induced-cerebellar-toxicity-in-quail-coturnix-c-coturnix-activating-pxr-car-pathway-responses-and-disrupting-cytochrome-p450-homeostasis
#4
Jun Xia, Lei Qin, Zheng-Hai Du, Jia Lin, Xue-Nan Li, Jin-Long Li
Atrazine is well known to be a biologically hazardous substance with toxic effects, but atrazine-induced neurotoxicity remains unclear. The aim of this study was to investigate the mechanisms of atrazine-induced cerebellar toxicity. To determine atrazine-exerted potential neurotoxicity, quails were treated with 50, 250 and 500 mg/kg atrazine by gavage administration for 45 days. Notably, the changes of cytochrome P450 enzyme system (CYP450s) were observed in atrazine-exposed quails. The contents of cytochrome P450 (CYP450) and Cytochrome b5 (Cyt b5) and the activities of NADPH-cytochrome c reductase (NCR), aminopyrin N-demethylase (APND) and aniline-4-hydeoxylase (AH) were increased and erythromycin N-demethylase (ERND) was decreased in quail cerebellum...
December 18, 2016: Chemosphere
https://www.readbyqxmd.com/read/28025000/determination-of-water-soluble-and-fat-soluble-vitamins-in-tears-and-blood-serum-of-infants-and-parents-by-liquid-chromatography-mass-spectrometry
#5
Maryam Khaksari, Lynn R Mazzoleni, Chunhai Ruan, Robert T Kennedy, Adrienne R Minerick
Tears serve as a viable diagnostic fluid with advantages including less invasive sample to collect and less complex to prepare for analysis. Several water-soluble and fat-soluble vitamins were detected and quantified in human tears and compared with blood serum levels. Samples from 15 family pairs, each pair consisting of a four-month-old infant and one parent were analyzed; vitamin concentrations were compared between tears and blood serum for individual subjects, between infants and parents, and against self-reported dietary intakes...
December 23, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/28011919/hpv-6-molecular-variants-association-with-the-development-of-genital-warts-in-men-the-him-study
#6
Ema Flores-Díaz, Karen A Sereday, Silvaneide Ferreira, Bradley Sirak, João Simão Sobrinho, Maria Luiza Baggio, Lenice Galan, Roberto C Silva, Eduardo Lazcano-Ponce, Anna R Giuliano, Luisa L Villa, Laura Sichero
BACKGROUND: HPV-6 and 11 are the etiological agents of approximately 90% genital warts (GWs). The impact of HPV-6 genetic heterogeneity on persistence and progression to GWs remains undetermined. METHODS: HPV Infection in Men (HIM) study participants who had HPV-6 genital swabs and/or GWs preceded by a viable normal genital swab were analyzed. Variants characterization was performed by PCR-sequencing and samples classified within lineages (A, B) and sub-lineages (B1, B2, B3, B4, B5)...
December 23, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28011355/elimination-of-representative-contaminant-candidate-list-viruses-coxsackievirus-echovirus-hepatitis-a-virus-and-norovirus-from-water-by-coagulation-processes
#7
N Shirasaki, T Matsushita, Y Matsui, K Murai, A Aochi
We examined the removal of representative contaminant candidate list (CCL) viruses (coxsackievirus [CV] B5, echovirus type [EV] 11, and hepatitis A virus [HAV] IB), recombinant norovirus virus-like particles (rNV-VLPs), and murine norovirus (MNV) type 1 by coagulation. Water samples were subjected to coagulation with polyaluminum chloride (PACl, basicity 1.5) followed by either settling or settling and filtration. Together with our previously published results, the removal ratio order, as evaluated by a plaque-forming-unit method or an enzyme-linked immunosorbent assay after settling, was HAV>EV=rNV-VLPs≥CV=poliovirus type 1=MNV>adenovirus type 40 (range, 0...
December 8, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28000554/a-homodimer-model-can-resolve-the-conundrum-as-to-how-cytochrome-p450-oxidoreductase-and-cytochrome-b5-compete-for-the-same-binding-site-on-cytochrome-p450c17
#8
Jessica K Holien, Michael W Parker, Alan J Conley, C Jo Corbin, Raymond J Rodgers, Lisandra L Martin
Cytochrome P450 17α-hydroxylase, 17,20-lyase (P450c17) is a key enzyme in the synthesis of cortisol in the zona fascicula of the adrenal cortex, and the synthesis of androgen precursors in the adrenal zona reticularis and the gonads. Each of these reactions require electrons transferred by the electron donor cytochrome P450 oxidoreductase. The 17-hydroxylation of its substrate occurs in all cells where P450c17 is expressed. Remarkably, a second, subsequent reaction, namely the 17,20-lyase activity, only occurs in the zona reticularis and gonads...
December 20, 2016: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/27999767/antimicrobial-efficacy-of-the-combination-of-chlorhexidine-digluconate-and-dexpanthenol
#9
Axel Kramer, Ojan Assadian, Torsten Koburger-Janssen
Objective: The objective of this standardised experimental study was to investigate the antimicrobial efficacy of the combination of chlorhexidine digluconate (CHX) and the anti-inflammatory pro-vitamin dexpanthenol, which stimulates wound-healing, in the form of Bepanthen(®) Antiseptic Wound Cream, in order to rule out possible antagonistic combination effects of CHX and the alcohol analogue of pantothenic acid (vitamin B5) dexpanthenol. Method: Testing was carried out using the quantitative suspension test at conditions simulating wound bio-burden...
2016: GMS Hygiene and Infection Control
https://www.readbyqxmd.com/read/27999424/polyphyletic-origin-of-mers-coronaviruses-and-isolation-of-a-novel-clade-a-strain-from-dromedary-camels-in-the-united-arab-emirates
#10
Susanna K P Lau, Renate Wernery, Emily Y M Wong, Sunitha Joseph, Alan K L Tsang, Nissy Annie Georgy Patteril, Shyna K Elizabeth, Kwok-Hung Chan, Rubeena Muhammed, Jöerg Kinne, Kwok-Yung Yuen, Ulrich Wernery, Patrick C Y Woo
Little is known regarding the molecular epidemiology of Middle East respiratory syndrome coronavirus (MERS-CoV) circulating in dromedaries outside Saudi Arabia. To address this knowledge gap, we sequenced 10 complete genomes of MERS-CoVs isolated from 2 live and 8 dead dromedaries from different regions in the United Arab Emirates (UAE). Phylogenetic analysis revealed one novel clade A strain, the first detected in the UAE, and nine clade B strains. Strain D998/15 had a distinct phylogenetic position within clade A, being more closely related to the dromedary isolate NRCE-HKU205 from Egypt than to the human isolates EMC/2012 and Jordan-N3/2012...
December 21, 2016: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/27992204/increased-back-bonding-explains-step-edge-reactivity-and-particle-size-effect-for-co-activation-on-ru-nanoparticles
#11
Lucas Foppa, Christophe Copéret, Aleix Comas-Vives
Carbon monoxide is a ubiquitous molecule, a key feedstock and intermediate in chemical processes. Its adsorption and activation, typically carried out on metallic nanoparticles (NPs), are strongly dependent on the particle size. In particular, small NPs, which in principle contain more corner and step-edge atoms, are surprisingly less reactive than larger ones. Hereby, first-principles calculations on explicit Ru NP models (1-2 nm) show that both small and large NPs can present step-edge sites (e.g., B5 and B6 sites)...
December 28, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27988639/remarkable-diversity-of-the-genus-i-endonura-i-cassagnau-1979-collembola-neanuridae-neanurinae-in-the-caucasus
#12
Adrian Smolis, Nataliya Kuznetsova
Endonura alticola (Stach, 1951) comb. nov. is redescribed based on the type material and seven new species of the genus Endonura are described from the various parts of the Caucasus. E. paracantabrica sp. nov. can be recognized by the number of chaetae (L+So) on head and a fusion of tubercles Di and De on the first thoracic segment. Specific traits of E. aibgai sp. nov. include small body size, low number of chaetae (L+So) on head, nonogival labrum, dentate claws, and long tibiotarsal chaetae B4 and B5. E. diminutichaeta sp...
November 27, 2016: Zootaxa
https://www.readbyqxmd.com/read/27979272/qcm-based-aptamer-selection-and-detection-of-salmonella-typhimurium
#13
Lijun Wang, Ronghui Wang, Fang Chen, Tieshan Jiang, Hong Wang, Michael Slavik, Hua Wei, Yanbin Li
In this study, quartz crystal microbalance (QCM) was used to select aptamers against Salmonella typhimurium. To increase the success rate of Systematic Evolution of Ligands Exponential Enrichment (SELEX), the affinity of DNA pool in each round was simultaneously tracked using QCM in order to avoid the loss of high-quality aptamers. When the frequency change reached a maximum value after several rounds of selection and counter-selection, the candidate pool was cloned and sequenced. Out of three aptamer candidates, aptamer B5 showed high specificity and binding affinity with dissociation constant (Kd value) of 58...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27936295/variability-of-pinus-halepensis-mill-essential-oils-and-their-antioxidant-activities-depending-on-the-stage-of-growth-during-vegetative-cycle
#14
Zineb Djerrad, Abderrahmane Djouahri, Leila Kadik
The impact of growth stages during vegetative cycle (B0 -B5 ) on chemical composition and antioxidant activities of Pinus halepensis Mill. needles essential oils was investigated for the first time. GC and GC-MS analyses pointed to a quantitative variability of components; terpene hydrocarbons derivatives, represented by α-pinene (8.5-12.9%), myrcene (17.5-21.6%), p-cymene (7.9-11.9%) and (Z)-β-caryophyllene (17.3-21.2%) as major components, decreased from 88.9% at B0 growth stage to 66.9% at B5 growth stage, whereas oxygenated derivatives, represented by caryophyllene oxide (5...
December 9, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27902385/motor-coordination-and-balance-measurements-reveal-differential-pathogenicity-of-currently-spreading-enterovirus-71-strains-in-human-scarb2-transgenic-mice
#15
Mei-Feng Chen, Shin-Ru Shih
Enterovirus 71 (EV71) has caused large-scale epidemics with neurological complications in the Asia-Pacific region. The C4a and B5 strains are the two major genotypes circulating in many countries recently. This study used a new protocol, a motor coordination task, to assess the differential pathogenicity of C4a and B5 strains in human SCARB2 transgenic mice. We found that the pathogenicity of C4a viruses was more severe than that of B5 viruses. Moreover, we discovered that an increased level of monocyte chemoattractant protein-1 was positively correlated with severely deficient motor function...
December 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27902270/aureimonas-glaciei-sp-nov-isolated-from-ice-core-china
#16
Bixi Guo, Yongqin Liu, Zhengquan Gu, Liang Shen, Keshao Liu, Tingting Xing, Ninglian Wang, Hongcan Liu, Yuguang Zhou, Jiule Li
A bacterial strain, B5-2T, was isolated from an ice core drilled from Muztagh Glacier, China. Strain B5-2T was a Gram-stain-negative, short rod-shaped, motile by polar flagella, aerobic bacterium. The major fatty acids of strain B5-2T were summed feature 8 (C18:1ω7c and/or C18:1ω6c) and iso-C13:0. The G+C content of the DNA from strain B5-2T was 69.3 mol%. The predominant isoprenoid quinone of strain B5-2T was Q-10. The major polar lipids were phosphatidylglycerol (PG), phosphatidylethanolamine (PE), phosphatidylmonomethylethanolamine (PME), phosphatidyldimethylethanolamine (PDE), phosphatidylcholine (PC), unidentified phospholipid (AL) and sulfoquinovosyldiacylglycerol (SQDG)...
November 14, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27900284/effect-of-pantethine-on-ovarian-tumor-progression-and-choline-metabolism
#17
Marie-France Penet, Balaji Krishnamachary, Flonne Wildes, Yelena Mironchik, Delia Mezzanzanica, Franca Podo, Max de Reggi, Bouchra Gharib, Zaver M Bhujwalla
Epithelial ovarian cancer remains the leading cause of death from gynecologic malignancy among women in developed countries. New therapeutic strategies evaluated with relevant preclinical models are urgently needed to improve survival rates. Here, we have assessed the effect of pantethine on tumor growth and metabolism using magnetic resonance imaging and high-resolution proton magnetic resonance spectroscopy (MRS) in a model of ovarian cancer. To evaluate treatment strategies, it is important to use models that closely mimic tumor growth in humans...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27899252/the-effects-of-metronidazole-on-cytochrome-p450-activity-and-expression-in-rats-after-acute-exposure-to-high-altitude-of-4300m
#18
Rong Wang, Yuhuan Sun, Qiang Yin, Hua Xie, Wenbin Li, Chang Wang, Jiankui Guo, Ying Hao, Rui Tao, Zhengping Jia
BACKGROUND: The purpose is to observe the changes of CYP450 enzyme activity expression as well as the physiological and pathological states of Wistar rats given metronidazole drug intervention after acute exposure to high altitude of 4300m. METHODS AND RESULTS: Thirty healthy adult male Wistar rats of average weight 200 ± 20 g were randomly assigned into three groups of 10 rats per group as follows: Group A (55m), Group B (4300m) and Group C (metronidazole intervention, 4300m)...
January 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27898958/technical-note-a-procedure-to-estimate-glucose-requirements-of-an-activated-immune-system-in-steers
#19
S K Kvidera, E A Horst, M Abuajamieh, E J Mayorga, M V Sanz Fernandez, L H Baumgard
: Infection and inflammation impede efficient animal productivity. The activated immune system ostensibly requires large amounts of energy and nutrients otherwise destined for synthesis of agriculturally relevant products. Accurately determining the immune system's in vivo energy needs is difficult, but a better understanding may facilitate developing nutritional strategies to maximize productivity. The study objective was to estimate immune system glucose requirements following an i...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27893219/integrating-the-context-appropriate-balanced-attention-model-and-reinforcement-sensitivity-theory-towards-a-domain-general-personality-process-model
#20
Michael D Collins, Chris J Jackson, Benjamin R Walker, Peter J O'Connor, Elliroma Gardiner
Over the last 40 years or more the personality literature has been dominated by trait models based on the Big Five (B5). Trait-based models describe personality at the between-person level but cannot explain the within-person mental mechanisms responsible for personality. Nor can they adequately account for variations in emotion and behavior experienced by individuals across different situations and over time. An alternative, yet understated, approach to personality architecture can be found in neurobiological theories of personality, most notably reinforcement sensitivity theory (RST)...
January 2017: Psychological Bulletin
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