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https://www.readbyqxmd.com/read/28217183/affection-of-the-respiratory-muscles-in-combined-complex-i-and-iv-deficiency
#1
Josef Finsterer, Helmut Rauschka, Liane Segal, Gabor G Kovacs, Boris Rolinski
OBJECTIVES: Combined complex I+IV deficiency has rarely been reported to manifest with the involvement of the respiratory muscles. CASE REPORT: A 45y male was admitted for hypercapnia due to muscular respiratory insufficiency. He required intubation and mechanical ventilation. He had a previous history of ophthalmoparesis since age 6y, ptosis since age 23y, and anterocollis since at least age 40y. Muscle biopsy from the right deltoid muscle at age 41y was indicative of mitochondrial myopathy...
2017: Open Neurology Journal
https://www.readbyqxmd.com/read/28194661/guillain-barre-syndrome-complicating-chikungunya-virus-infection
#2
Ayush Agarwal, Deepti Vibha, Achal Kumar Srivastava, Garima Shukla, Kameshwar Prasad
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus which presents with symptoms of fever, rash, arthralgia, and occasional neurologic disease. While outbreaks have been earlier reported from India and other parts of the world, the recent outbreak in India witnessed more than 1000 cases. Various systemic and rarely neurological complications have been reported with CHIKV. We report two cases of Guillain-Barré syndrome (GBS) with CHIKV. GBS is a rare neurological complication which may occur after subsidence of fever and constitutional symptoms by several neurotropic viruses...
February 13, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28091723/changes-in-the-severity-and-subtype-of-guillain-barr%C3%A3-syndrome-admitted-to-a-specialist-neuromedical-icu-over-a-25%C3%A2-year-period
#3
C J Taylor, N P Hirsch, D M Kullmann, Robin S Howard
We report a retrospective review of 110 patients with acute Guillain-Barré syndrome (GBS) admitted to a specialised intensive care unit (ICU) in a tertiary referral centre over a 25 year period, the start of which coincided with the widespread introduction of plasma exchange (PE) and intravenous immunoglobulin (IVIG). The results were analysed by comparing 52 patients admitted in the first decade (1991-2000; Group 1) with 58 patients admitted between 2001-2014 (Group 2). Patients in both groups were comparable with respect to age and sex, and had a similar incidence and range of ICU complications...
January 16, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28042370/review-of-critical-illness-myopathy-and-neuropathy
#4
Starane Shepherd, Ayush Batra, David P Lerner
Critical illness myopathy (CIM) and neuropathy are underdiagnosed conditions within the intensive care setting and contribute to prolonged mechanical ventilation and ventilator wean failure and ultimately lead to significant morbidity and mortality. These conditions are often further subdivided into CIM, critical illness polyneuropathy (CIP), or the combination-critical illness polyneuromyopathy (CIPNM). In this review, we discuss the epidemiology and pathophysiology of CIM, CIP, and CIPNM, along with diagnostic considerations such as detailed clinical examination, electrophysiological studies, and histopathological review of muscle biopsy specimens...
January 2017: Neurohospitalist
https://www.readbyqxmd.com/read/28010677/cochlear-implantation-in-chronic-demyelinating-inflammatory-polyneuropathy
#5
Sarah E Mowry, Sarah King
OBJECTIVE: To describe a case of chronic inflammatory demyelinating polyneuropathy (CDIP) with bilateral sudden sensorineural hearing loss who subsequently benefited from unilateral cochlear implantation. METHODS: case history review and review of the literature for the terms CDIP, hearing loss, cochleovestibular dysfunction, and cochlear implantation. RESULTS: A 49-year-old woman presented with bilateral rapidly progressive sensorineural hearing loss (SNHL) 1 month after an upper respiratory tract infection...
December 23, 2016: Cochlear Implants International
https://www.readbyqxmd.com/read/27973938/anesthetic-management-of-a-patient-with-ehlers-danlos-syndrome
#6
Naohiro Ohshita, Masahiko Kanazumi, Kaname Tsuji, Hiroaki Yoshida, Shosuke Morita, Yoshihiro Momota, Yasuo M Tsutsumi
We describe the case of a 37-year-old woman who had been diagnosed with Ehlers-Danlos syndrome (EDS) 4 years earlier and was scheduled to undergo removal of synovial chondromatosis in the temporomandibular joint. EDS is a heritable connective tissue disorder and has 6 types. In this case, the patient was classified into EDS hypermobility type. The major clinical feature of this type is joint hypermobility. The patient had sprain or subluxation of the elbows and ankles and dislocation of the knees. Anticipated problems during general anesthesia would be affected by the disease type...
2016: Anesthesia Progress
https://www.readbyqxmd.com/read/27903001/right-in-front-of-our-eyes-evolution-of-streptococcal-toxic-shock-syndrome-with-ischemic-optic-neuropathy
#7
Salaheldin M Elhamamsy, Mazen O Al-Qadi, Taro Minami, Marguerite Neill
INTRODUCTION: Toxic shock syndrome occurs from dysregulation of host inflammatory responses. Toxin- producing strains of Group A streptococcus cause TSS. Ischemic optic neuropathy rarely complicates septic shock. We present a rare case of streptococcal pharyngitis complicated by septic arthritis and TSS with reversible blindness due to non-arteritic ischemic optic neuropathy. CASE: A 28-year-old man drove to our ED with exudative pharyngitis. A rapid streptococcal test was positive...
December 1, 2016: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/27891239/two-cases-of-methyl-alcohol-intoxication-by-sub-chronic-inhalation-and-dermal-exposure-during-aluminum-cnc-cutting-in-a-small-sized-subcontracted-factory
#8
Jia Ryu, Key Hwan Lim, Dong-Ryeol Ryu, Hyang Woon Lee, Ji Young Yun, Seoung-Wook Kim, Ji-Hoon Kim, Kyunghee Jung-Choi, Hyunjoo Kim
BACKGROUND: Methyl alcohol poisoning has been mainly reported in community. Two cases of methyl alcohol poisoning occurred in a small-sized subcontracted factory which manufactured smartphone parts in Korea. CASE PRESENTATION: One young female patient presented with dyspnea and visual disturbance. Another young male patient presented with visual disturbance and myalgia. They treated with sodium bicarbonate infusion and hemodialysis for metabolic acidosis. In addition, he received ethyl alcohol per oral treatment...
2016: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27676820/evaluation-of-disabilities-and-rehabilitation-needs-after-critical-illness-impact-of-an-intensive-care-unit-follow-up-clinic-in-the-university-hospital-of-angers
#9
Tiphaine Bourseau, Flavie Fremondière, Valérie Dubus, Bénédicte Gohier, Dewi Le Gal, Fabien Cave, Isabelle Richard, Nicolas Lerolle
OBJECTIVE: After critical illness, some survivors experience long-term physical, functional, neurocognitive and/or mental health impairments, which has been termed "Post-Intensive Care syndrome" (PICS) [1]. A specific follow-up is required and many specialized follow-up clinics have been created both abroad and in France. The aim of this study is to evaluate long-term outcomes after critical illness, through the International Classification of Functioning, Disability and Health, and to analyse rehabilitation needs after intensive care unit (ICU) discharge...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27596231/an-unusual-case-of-recurrent-guillain-barr%C3%A3-syndrome-with-normal-cerebrospinal-fluid-protein-levels-a-case-report
#10
Sonali Sihindi Chapa Gunatilake, Rohitha Gamlath, Harith Wimalaratna
BACKGROUND: Guillain-Barré syndrome is an acquired polyradiculo-neuropathy, often preceded by an antecedent event. It is a monophasic disease but a recurrence rate of 1-6 % is documented in a subset group of patients. Patients with Guillain-Barré syndrome show cerebrospinal fluid albuminocytologic dissociation. Normal cerebrospinal fluid protein levels during both initial and recurrent episodes of Guillain-Barré syndrome is a rare occurrence and has not been described earlier in the literature...
September 5, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27477576/guillan-barr%C3%A3-syndrome-following-scrub-typus-two-case-reports
#11
Katsuya Sakai, Nobuyuki Ishii, Yuka Ebihara, Hitoshi Mochizuki, Kazutaka Shiomi, Masamitsu Nakazato
Case 1: A 66-year-old man was admitted because of progressive gait disturbance and dysphagia after developing red rash. He was diagnosed as Guillain-Barré syndrome (GBS) and treated by intravenous immunoglobulin therapy (IVIg). Two weeks later, he could swallow and walk without any abnormalities. Case 2: A 58-year-old woman was admitted because of gait disturbance, bilateral peripheral facial nerve palsies, and respiratory failure one week after developing fever and rash. She was diagnosed as GBS and treated with IVIg...
August 31, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/27442657/failing-phrenics-an-obscure-cause-of-exertional-dyspnea-case-report-and-literature-review
#12
REVIEW
Arsalan Rafiq, Mohsin Ijaz, Hassan Tariq, Trupti Vakde, Richard Duncalf
INTRODUCTION: Idiopathic phrenic nerve palsy is a rare cause of exertional dyspnea. We present a case of a patient presenting with worsening dyspnea of an unknown etiology found to be related to bilateral phrenic nerve palsy. DISCUSSION: Forty-two-year-old man presented to our emergency department with exertional dyspnea, orthopnea, and a left lower lobe consolidation treated initially as bronchitis by his primary physician as an outpatient, then subsequently as pneumonia at another institution, with no improvement in symptomatology...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27381107/acute-physiology-and-chronic-health-evaluation-ii-score-of-%C3%A2-15-a-risk-factor-for-sepsis-induced-critical-illness-polyneuropathy
#13
Salil Gupta, Mayank Mishra
BACKGROUND: Critical illness polyneuropathy (CIP) is a common complication of severe sepsis and systemic inflammatory response syndrome (SIRS). The risk factors for sepsis-induced CIP have not been well established. AIM: The aim of this study was to find out the risk factors of sepsis-induced CIP, especially its relationship with the severity of illness. PATIENTS AND METHODS: A cohort of 100 patients with sepsis defined as SIRS of proven or presumed microbial etiology were followed up with nerve conduction studies (NCS) performed within the first 14 days of admission...
July 2016: Neurology India
https://www.readbyqxmd.com/read/27247582/prognosis-of-guillain-barr%C3%A3-syndrome-in-children
#14
Mohammad Reza Salehiomran, Ali Nikkhah, Mohadese Mahdavi
OBJECTIVE: Guillain-Barre Syndrome (GBS) is an acute polyradiculoneuropathy characterized by progressive motor weakness of limbs and areflexia. In this study, our aim was to evaluate the clinical pattern and prognosis of children with Guillain-Barre syndrome. MATERIALS & METHODS: This cross-sectional study was conducted in the Pediatric Neurology Unit of Amirkola Children's Hospital, Babol, Iran during the period of 5 years from October 2008 to September 2013. We assessed the clinical features, results of electrodiagnostic tests, functional status, treatment and outcome of 17 children diagnosed with GBS...
2016: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/27063347/icu-acquired-weakness
#15
REVIEW
Sarah E Jolley, Aaron E Bunnell, Catherine L Hough
Survivorship after critical illness is an increasingly important health-care concern as ICU use continues to increase while ICU mortality is decreasing. Survivors of critical illness experience marked disability and impairments in physical and cognitive function that persist for years after their initial ICU stay. Newfound impairment is associated with increased health-care costs and use, reductions in health-related quality of life, and prolonged unemployment. Weakness, critical illness neuropathy and/or myopathy, and muscle atrophy are common in patients who are critically ill, with up to 80% of patients admitted to the ICU developing some form of neuromuscular dysfunction...
November 2016: Chest
https://www.readbyqxmd.com/read/27051622/acute-ischemic-optic-neuropathy-with-extended-prone-position-ventilation-in-a-lung-transplant-recipient
#16
Tanmay S Panchabhai, Debabrata Bandyopadhyay, Aanchal Kapoor, Olufemi Akindipe, Charles Lane, Sudhir Krishnan
Prone position ventilation (PPV) improves mortality in severe acute respiratory distress syndrome (ARDS), but outcomes following its use in lung transplant recipients are not known. We report the case of a 42-year-old Caucasian man who presented with severe ARDS from Bordetella pertussis, 5 years after bilateral sequential lung transplant for cystic fibrosis. He was managed with PPV for 22 days and had a prolonged ICU stay complicated by hypoxic ischemic optic neuropathy leading to blindness. Since his discharge from the ICU 6 months ago, his FEV1 has recovered to 47% predicted compared to his pre-ICU peak FEV1 of 85% predicted, suggesting recovery of lung function...
January 2016: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/27025126/-characteristics-of-surface-electromyography-and-acid-base-balance-in-patients-with-intensive-care-unit-acquired-weakness
#17
A Yu Mejgal, O G Tret'jakova, A P Spasova
OBJECTIVE: The study was aimed to search for correlation between parameters of surface electromyography and acid-base balance (ABB) in patients with intensive care unit-acquired weakness (ICUAW, n = 29, duration 7-180 days). METHODS: The linear and nonlinear parameters of sEMG (mean frequency of spectrum, fractal and correlation dimension, correlation entropy) and ABB and their correlation coefficient with bed rest (BR) and duration of mechanical ventilation (MT) were computed...
November 2015: Anesteziologiia i Reanimatologiia
https://www.readbyqxmd.com/read/26999767/neuropsychiatric-manifestations-in-inflammatory-neuropathies-a-systematic-review
#18
REVIEW
Yusuf A Rajabally, Stefano Seri, Andrea E Cavanna
We conducted a systematic literature review on psychological and behavioral comorbidities in patients with inflammatory neuropathies. In Guillain-Barré syndrome (GBS), psychotic symptoms are reported during early stages in 30% of patients. Typical associations include mechanical ventilation, autonomic dysfunction, inability to communicate, and severe weakness. Anxiety and depression are frequent comorbidities. Anxiety may increase post-hospital admissions and be a predictor of mechanical ventilation. Posttraumatic stress disorder may affect up to 20% of ventilated patients...
June 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/26974666/distinct-clinical-characteristics-of-pediatric-guillain-barr%C3%A3-syndrome-a-comparative-study-between-children-and-adults-in-northeast-china
#19
COMPARATIVE STUDY
Xiujuan Wu, Donghui Shen, Ting Li, Bing Zhang, Chunrong Li, Mei Mao, Jixue Zhao, Kangding Liu, Hong-Liang Zhang
OBJECTIVE: Clinical characteristics of pediatric Guillain-Barré syndrome (GBS) have been extensively studied whereas scarcely been compared with those of adult GBS. Herein we compared the clinical features of GBS between pediatric and adult patients. METHODS: We retrospectively collected the clinical data of 750 patients with GBS (541 adults and 209 children), and compared the clinical characteristics between children and adults. RESULTS: Pain was a more frequent complaint in children (17...
2016: PloS One
https://www.readbyqxmd.com/read/26955893/autosomal-recessive-mfn2-related-charcot-marie-tooth-disease-with-diaphragmatic-weakness-case-report-and-literature-review
#20
Christopher A Tan, Marina Rabideau, Amy Blevins, Marjorie Jody Westbrook, Tali Ekstein, Keith Nykamp, Anne Deucher, Amy Harper, Laurie Demmer
Pathogenic variants in the mitofusin 2 gene (MFN2) are the most common cause of autosomal dominant Charcot-Marie-Tooth (CMT2) disease, which is typically characterized by axonal sensorimotor neuropathy. We report on a 7-month-old white female with hypotonia, motor delay, distal weakness, and motor/sensory axonal neuropathy in which next-generation sequencing analysis identified compound heterozygous pathogenic variants (c.2054_2069_1170del and c.392A>G) in MFN2. A review of the literature reveals that sporadic and familial cases of compound heterozygous or homozygous pathogenic MFN2 variants have been infrequently described, which indicates that MFN2 can also be inherited in a recessive manner...
June 2016: American Journal of Medical Genetics. Part A
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