keyword
https://read.qxmd.com/read/38546913/genetic-variations-related-to-angiotensin-ii-production-and-risk-for-basal-cell-carcinoma
#1
REVIEW
Iphigenia Gintoni, Michael Mastrogeorgiou, Veronica Papakosta, Stavros Vassiliou, Christos Yapijakis
Basal cell carcinoma (BCC) is the most prevalent human neoplasm, with constantly increasing annual incidence. Despite its slow growth, BCC is locally invasive and, if left untreated, can cause severe complications, including metastasis and death. The renin-angiotensin system (RAS) plays a key role in electrolyte balance, atrial pressure, tissue development, homeostasis, and inflammation, but also in cancer development. After binding to its type 1 receptor (AT1R), angiotensin II (ANGII), the system's principal hormonal effector, regulates cancer pathways spanning from the formation of the initial cancer cell to the construction and nutrition of the tumor microenvironment, angiogenesis, proliferation, and metastasis...
March 28, 2024: Biochemical Genetics
https://read.qxmd.com/read/38545090/efficacy-of-oral-20-hydroxyecdysone-bio101-a-mas-receptor-activator-in-adults-with-severe-covid-19-cova-a%C3%A2-randomized-placebo-controlled-phase-2-3-trial
#2
JOURNAL ARTICLE
Suzana Margareth Lobo, Gaétan Plantefève, Girish Nair, Adilson Joaquim Cavalcante, Nara Franzin de Moraes, Estevao Nunes, Otis Barnum, Claudio Marcel Berdun Stadnik, Maria Patelli Lima, Muriel Lins, Ludhmila Abrahao Hajjar, Christopher Lipinski, Shaheen Islam, Fabiano Ramos, Tiago Simon, Jean-Benoît Martinot, Thomas Guimard, Arnaud Desclaux, Bertrand Lioger, Fernando Carvalho Neuenschwander, Bruno DeSouza Paolino, Alpesh Amin, Samuel Amil Acosta, Daniel Forde Dilling, Edgardo Cartagena, Brian Snyder, Edouard Devaud, Ana Karolina Barreto Berselli Marinho, Suzana Tanni, Patricia Medeiros Milhomem Beato, Stephan De Wit, Vani Selvan, Jeffrey Gray, Ricardo Fernandez, Valérie Pourcher, Lee Maddox, Richard Kay, Anait Azbekyan, Mounia Chabane, Cendrine Tourette, Luis Everton Esmeraldino, Pierre J Dilda, René Lafont, Jean Mariani, Serge Camelo, Sandrine Rabut, Samuel Agus, Stanislas Veillet, Waly Dioh, Rob van Maanen, Capucine Morelot-Panzini
BACKGROUND: SARS-CoV-2 binding to ACE2 is potentially associated with severe pneumonia due to COVID-19. The aim of the study was to test whether Mas-receptor activation by 20-hydroxyecdysone (BIO101) could restore the Renin-Angiotensin System equilibrium and limit the frequency of respiratory failure and mortality in adults hospitalized with severe COVID-19. METHODS: Double-blind, randomized, placebo-controlled phase 2/3 trial. Randomization: 1:1 oral BIO101 (350 mg BID) or placebo, up to 28 days or until an endpoint was reached...
February 2024: EClinicalMedicine
https://read.qxmd.com/read/38543635/the-renin-angiotensin-system-ras-in-covid-19-disease-where-we-are-3-years-after-the-beginning-of-the-pandemic
#3
REVIEW
Marco Prato, Natalia Tiberti, Cristina Mazzi, Federico Gobbi, Chiara Piubelli, Silvia Stefania Longoni
The RAS is a hormonal system playing a pivotal role in the control of blood pressure and electrolyte homeostasis, the alteration of which is associated with different pathologies, including acute respiratory distress syndrome (ARDS). As such, it is not surprising that a number of studies have attempted to elucidate the role and balance of the renin-angiotensin system (RAS) in COVID-19. In this review article, we will describe the evidence collected regarding the two main enzymes of the RAS (i.e., ACE and ACE2) and their principal molecular products (i...
March 14, 2024: Microorganisms
https://read.qxmd.com/read/38542273/the-renin-angiotensin-system-and-cardiovascular-kidney-metabolic-syndrome-focus-on-early-life-programming
#4
REVIEW
You-Lin Tain, Chien-Ning Hsu
The identification of pathological links among metabolic disorders, kidney ailments, and cardiovascular conditions has given rise to the concept of cardiovascular-kidney-metabolic (CKM) syndrome. Emerging prenatal risk factors seem to increase the likelihood of CKM syndrome across an individual's lifespan. The renin-angiotensin system (RAS) plays a crucial role in maternal-fetal health and maintaining homeostasis in cardiovascular, metabolic, and kidney functions. This review consolidates current preclinical evidence detailing how dysregulation of the RAS during pregnancy and lactation leads to CKM characteristics in offspring, elucidating the underlying mechanisms...
March 14, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541022/fasting-glp-1-levels-and-albuminuria-are-negatively-associated-in-patients-with-type-2-diabetes-mellitus
#5
JOURNAL ARTICLE
Cheol-Won Jang, Tae Yang Yu, Jin Woo Jeong, Se Eun Ha, Rajan Singh, Moon Young Lee, Seungil Ro
Glucagon-like peptide-1 (GLP-1) is an incretin hormone known for its pivotal role in enhancing insulin secretion and reducing glucagon release from the pancreas. Diabetic nephropathy, which is characterized by albuminuria, represents a significant microvascular complication of diabetes. Most of the previous studies mainly focused on the therapeutic renal protective effect in clinical trials after the administration of GLP-1 receptor agonists (GLP-1 RAs), rather than before administration. Hence, this study aimed to investigate the association between fasting plasma GLP-1 levels and albuminuria before GLP-1 RA administration...
March 1, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38540270/transforming-diabetes-care-the-molecular-pathways-through-which-glp1-ras-impact-the-kidneys-in-diabetic-kidney-disease
#6
REVIEW
Merita Rroji, Goce Spasovski
Diabetic kidney disease (DKD) is a substantial complication of type 2 diabetes (T2D), presenting challenges in chronic kidney disease (CKD) management. In addition to traditional and recent therapies, including angiotensin, converting enzyme (ACE) inhibitors, angiotensin receptor blockers, sodium-glucose cotransporter 2 (SGLT2) inhibitors, and mineralocorticoid receptor antagonists, the evolution of antihyperglycemic treatments has introduced a promising agent, glucagon-like peptide-1 receptor agonist (GLP-1RA) for the management of DKD...
March 14, 2024: Biomedicines
https://read.qxmd.com/read/38537386/non-steroidal-anti-inflammatory-drugs-renin-angiotensin-system-blockade-or-diuretics-and-risk-of-acute-kidney-injury-a-case-crossover-study
#7
JOURNAL ARTICLE
Shao-En Weng, Wan-Tseng Hsu, Fei-Yuan Hsiao, Chii-Ming Lee
BACKGROUND: Aging-related physiological changes, such as decline in renal function, not only exacerbates pre-existing comorbidities but also escalate the susceptibility to adverse events. Previous studies have shown that non-steroidal anti-inflammatory drugs (NSAIDs) are associated with an increased risk of acute kidney injury (AKI), and the concomitant use of renin-angiotensin system blockade or diuretics may further potentiate the risk. However, studies evaluating the risk of AKI associated with NSAIDs (including routes, concomitant use of different NSAIDs, categories (traditional NSAIDs or COX-2 inhibitors), and cumulative doses of NSAIDs) are limited, particularly the risk of AKI associated with the dual or triple combination of NSAIDs with renin-angiotensin system blockade (RAS blockades) and/or diuretics...
March 26, 2024: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/38537216/unusual-renal-uptake-of-131i-mibg-in-a-young-hypertensive-with-renal-artery-stenosis
#8
JOURNAL ARTICLE
Agrawal Roopal, Malhotra Gaurav
A 10-year-old hypertensive girl underwent 131I-MIBG scan to rule out neural crest derived tumor. The whole-body images revealed diffuse intense tracer uptake in the right kidney, which persisted in 96-hour images as well. CT renal angiography revealed 90% to 95% right renal artery stenosis. Thereafter, she underwent baseline and angiotensin receptor blockade renal dynamic imaging, which revealed hemodynamically significant renal artery stenosis. Pattern of diffuse and intense 131I-MIBG uptake, albeit rare, still warrants further evaluation to rule out renal artery stenosis and investigate its hemodynamic significance for appropriate management...
March 25, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38534729/assessment-of-the-pro-renin-receptor-protein-expression-in-organs
#9
JOURNAL ARTICLE
Teng-Yao Yang, Pey-Jium Chang, Yu-Shien Ko, Siou-Ru Shen, Shun-Fu Chang
The (pro)renin receptor ((P)RR) is an essential component of the renin-angiotensin system (RAS) as a specific single-pass transmembrane receptor for prorenin and renin and has now emerged as a multifunctional protein implicated in a wide variety of developmental and physio-pathological processes and pathways. The (P)RR may be of pathological significance in metabolic syndrome. The (P)RR has received much consideration; substantial efforts have been made to understand the localization, regulation, and function of the (P)RR at both a molecular and system level...
February 25, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38516874/the-potential-for-improved-outcomes-in-the-prevention-and-therapy-of-diabetic-kidney-disease-through-stacking-of-drugs-from-different-classes
#10
REVIEW
David S H Bell, Terri Jerkins
Aggressive therapy of diabetic kidney disease (DKD) can not only slow the progression of DKD to renal failure but, if utilized at an early enough stage of DKD, can also stabilize and/or reverse the decline in renal function. The currently recognized standard of therapy for DKD is blockade of the renin-angiotensin system with angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs). However, unless utilized at a very early stage, monotherapy with these drugs in DKD will only prevent or slow the progression of DKD and will neither stabilize nor reverse the progression of DKD to renal decompensation...
March 22, 2024: Diabetes, Obesity & Metabolism
https://read.qxmd.com/read/38511994/renin-levels-and-angiotensin-ii-responsiveness-in-vasopressor-dependent-hypotension
#11
JOURNAL ARTICLE
Emily J See, Anis Chaba, Sofia Spano, Akinori Maeda, Caroline Clapham, Louise M Burrell, Jasmine Liu, Monique Khasin, Grace Liskaser, Glenn Eastwood, Rinaldo Bellomo
OBJECTIVES: The relationship between renin levels, exposure to renin-angiotensin system (RAS) inhibitors, angiotensin II (ANGII) responsiveness, and outcome in patients with vasopressor-dependent vasodilatory hypotension is unknown. DESIGN: We conducted a single-center prospective observational study to explore whether recent RAS inhibitor exposure affected baseline renin levels, whether baseline renin levels predicted ANGII responsiveness, and whether renin levels at 24 hours were associated with clinical outcomes...
March 21, 2024: Critical Care Medicine
https://read.qxmd.com/read/38507510/kidney-renin-angiotensin-system-lost-in-a-ras-cascade
#12
JOURNAL ARTICLE
Steven D Crowley, L Gabriel Navar, Minolfa C Prieto, Susan B Gurley, Thomas M Coffman
Renin was discovered more than a century ago. Since then, the functions of the renin-angiotensin system in the kidney have been the focus of intensive research revealing its importance in regulation of renal physiology and in the pathogenesis of heart, vascular, and kidney diseases. Inhibitors of renin-angiotensin system components are now foundational therapies for a range of kidney and cardiovascular diseases from hypertension to heart failure to diabetic nephropathy. Despite years of voluminous research, emerging studies continue to reveal new complexities of the regulation of the renin-angiotensin system within the kidney and identification of nonclassical components of the system like the prorenin receptor (PRR) and ACE2 (angiotensin-converting enzyme 2), with powerful renal effects that ultimately impact the broader cardiovascular system...
April 2024: Hypertension
https://read.qxmd.com/read/38505676/protective-effects-of-limb-remote-ischemic-per-conditioning-on-the-heart-injury-induced-by-renal-ischemic-reperfusion-through-the-interaction-of-the-apelin-with-the-ras-inos-pathway
#13
JOURNAL ARTICLE
Sahar Janfeshan, Fatemeh Masjedi, Zeinab Karimi
INTRODUCTION: Remote ischemic conditioning upregulates endogenous protective pathways in response to ischemia-reperfusion injury. This study tested the hypothesis that limb remote ischemic per- conditioning (RIPerC) exerts cardioprotective effects via the renin-angiotensin system (RAS)/inducible nitric oxide synthase (iNOS)/apelin pathway. METHODS: Renal ischemia-reperfusion injury (I/R) was induced by bilateral occlusion of the renal pedicles for 60 minutes, followed by 24 hours of reperfusion; sham-operated rats served as controls...
2024: BioImpacts: BI
https://read.qxmd.com/read/38501595/four-week-inhibition-of-the-renin-angiotensin-system-in-spontaneously-hypertensive-rats-results-in-persistently-lower-blood-pressure-with-reduced-kidney-renin-and-changes-in-expression-of-relevant-gene-networks
#14
JOURNAL ARTICLE
Sean G Byars, Priscilla Prestes, Vara Suphapimol, Fumihiko Takeuchi, Nathan De Vries, Michelle C Maier, Mariana Melo, David Balding, Nilesh Samani, Andrew M Allen, Norihiro Kato, Jennifer L Wilkinson-Berka, Fadi Charchar, Stephen B Harrap
AIMS: Prevention of human hypertension is an important challenge and has been achieved in experimental models. Brief treatment with renin-angiotensin system (RAS) inhibitors permanently reduces the genetic hypertension of the spontaneously hypertensive rat (SHR). The kidney is involved in this fascinating phenomenon, but relevant changes in gene expression are unknown. METHODS: In SHR, we studied the effect of treatment between 10 and 14 weeks of age with the angiotensin receptor blocker, losartan, or the angiotensin-converting enzyme (ACE) inhibitor, perindopril (with controls for non-specific effects of lowering BP) on differential RNA expression, DNA methylation and renin immunolabelling in the kidney at 20 weeks of age...
March 19, 2024: Cardiovascular Research
https://read.qxmd.com/read/38501167/reviving-decades-old-wisdom-longitudinal-analysis-of-renin-angiotensin-system-inhibitors-and-its-effects-on-acute-ischemic-stroke-to-improve-outcomes
#15
JOURNAL ARTICLE
Sophie Samuel, Kyndol Craver, Charles Miller, Brittany Pelsue, Catherine Gonzalez, Teresa A Allison, Brian Gulbis, H Alex Choi, Seokhun Kim
BACKGROUND: While Renin-Angiotensin System (RAS) inhibitors have a longstanding history in blood pressure control, their suitability as first-line in-patient treatment may be limited due to prolonged half-life and kidney failure concerns. METHODS: Using a cohort design, we assessed the impact of RAS inhibitors, either alone or in combination with beta-blockers, on mortality, while exploring interactions, including those related to end-stage renal disease and serum creatinine levels...
March 19, 2024: American Journal of Hypertension
https://read.qxmd.com/read/38499437/2023-diabetic-kidney-disease-fact-sheet-in-korea
#16
JOURNAL ARTICLE
Nam Hoon Kim, Mi-Hae Seo, Jin Hyung Jung, Kyung Do Han, Mi Kyung Kim, Nan Hee Kim
BACKGROUND: To investigate the prevalence, incidence, comorbidities, and management status of diabetic kidney disease (DKD) and diabetes-related end-stage kidney disease (ESKD) in South Korea. METHODS: We used the Korea National Health and Nutrition Examination Survey data (2019 to 2021, n=2,665) for the evaluation of prevalence, comorbidities, control rate of glycemia and comorbidities in DKD, and the Korean Health Insurance Service-customized database (2008 to 2019, n=3,950,857) for the evaluation of trends in the incidence and prevalence rate of diabetes-related ESKD, renin-angiotensin system (RAS) blockers and sodium glucose cotransporter 2 (SGLT2) inhibitors use for DKD, and the risk of atherosclerotic cardiovascular disease (ASCVD) and mortality according to DKD stages...
March 19, 2024: Diabetes & Metabolism Journal
https://read.qxmd.com/read/38490519/identification-of-18%C3%AE-glycyrrhetinic-acid-as-an-agt-inhibitor-against-lps-induced-myocardial-dysfunction-via-high-throughput-screening
#17
JOURNAL ARTICLE
Mengying Shi, Shujing Zhang, Jiabing Rong, Zetao Heng, Yinchuan Xu, Yi Wang, Zhaocai Zhang
Sepsis induced myocardial dysfunction (SIMD) is a serious complication of sepsis. There is increasing evidence that the renin-angiotensin system (RAS) is activated in SIMD. Angiotensinogen (AGT) is a precursor of the RAS, and the inhibition of AGT may have significant cardiovascular benefits. But until now, there have been no reports of small molecule drugs targeting AGT. In this study, we designed a promoter-luciferase based system to screen for novel AGT inhibitors to alleviate SIMD. As a result of high-throughput screening, a total of 5 compounds from 351 medicinal herb-derived natural compounds were found inhibiting AGT...
March 13, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38488216/unraveling-the-crosstalk-between-renin-angiotensin-system-receptors
#18
REVIEW
Mariela M Gironacci, Ezequiel Bruna-Haupt
The renin-angiotensin system (RAS) plays a key role in blood pressure regulation. The RAS is a complex interconnected system composed of two axes with opposite effects. The pressor arm, represented by angiotensin (Ang) II and the AT1 receptor (AT1 R), mediates the vasoconstrictor, proliferative, hypertensive, oxidative, and pro-inflammatory effects of the RAS, while the depressor/protective arm, represented by Ang-(1-7), its Mas receptor (MasR) and the AT2 receptor (AT2 R), opposes the actions elicited by the pressor arm...
March 15, 2024: Acta Physiologica
https://read.qxmd.com/read/38483874/vitamin-d-deficiency-and-the-vitamin-d-receptor-vdr-gene-polymorphism-rs2228570-foki-are-associated-with-an-increased-susceptibility-to-hypertension-among-the-bangladeshi-population
#19
JOURNAL ARTICLE
Imrul Kayes Nabil, Zimam Mahmud, Sonia Tamanna, Md Mostafijur Rahman, Gowhar Rashid, Md Sarowar Hossain, Humaira Binte Asad, Mohammad Amjad Kamal, Md Zakir Hossain Howlader
Vitamin D receptor (VDR) gene is implicated in hypertension vulnerability due to its role in regulating the renin-angiotensin system (RAS) and blood pressure. In this case-control study, a carefully selected cohort of 111 hypertensive individuals and 100 healthy controls underwent serum analysis using HPLC to measure 25-hydroxy vitamin D levels. Polymorphic variations in the VDR gene were detected and characterized using the PCR-RFLP method. At first, lower 25-hydroxy vitamin D levels were observed in hypertensive individuals compared to controls (p<0...
2024: PloS One
https://read.qxmd.com/read/38472752/oral-administration-of-fermented-milk-from-co-starter-containing-lactobacillus-plantarum-y44-shows-an-ameliorating-effect-on-hypertension-in-spontaneously-hypertensive-rats
#20
JOURNAL ARTICLE
Jiang Yu, Mengying Sun, Shilong Jiang, Chuqi Jiang, Guangqing Mu, Yanfeng Tuo
Fermented dairy foods such as yogurt exhibit some beneficial effects on consumers, including relieving the symptoms of hypertension. This study aims to obtain fermented dairy products from a co-starter that have a great flavor and the auxiliary function of reducing blood pressure after longtime consumption. Commercial starter cultures composed of Lactobacillus delbrueckii subsp. bulgaricus CICC 6047 and Streptococcus thermophilus CICC 6038 were combined with Lactobacillus plantarum strains Y44, Y12, and Y16, respectively, as a combined starter culture to ferment the mixed milk of skim milk and soybean milk...
February 20, 2024: Foods (Basel, Switzerland)
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