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https://www.readbyqxmd.com/read/29774614/photochemistry-for-well-defined-polymers-in-aqueous-media-from-fundamentals-to-polymer-nanoparticles-to-bioconjugates
#1
REVIEW
Kevin M Burridge, Thaiesha A Wright, Richard C Page, Dominik Konkolewicz
This review article highlights recent developments in the field of photochemistry and photochemical reversible deactivation radical polymerization applied to aqueous polymerizations. Photochemistry is a topic of significant interest in the fields of organic, polymer, and materials chemistry because it allows challenging reactions to be performed under mild conditions. Aqueous polymerization is of significant interest because water is an environmentally benign solvent, and the use of water enables complex polymer self-assembly and bioconjugation processes to occur...
May 17, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29774191/traumatic-optic-neuropathy
#2
REVIEW
Sun Young Jang
Traumatic optic neuropathy (TON) refers to optic nerve injury resulting from direct and indirect head and facial trauma. The pathogenesis of indirect TON has not been fully elucidated, and the management of TON remains controversial. In this review article, I review the recent literature regarding TON and discuss how to manage indirect TON.
April 2018: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/29774045/transposon-derived-non-coding-rnas-and-their-function-in-plants
#3
REVIEW
Jungnam Cho
Transposable elements (TEs) are often regarded as harmful genomic factors and indeed they are strongly suppressed by the epigenetic silencing mechanisms. On the other hand, the mobilization of TEs brings about variability of genome and transcriptome which are essential in the survival and evolution of the host species. The vast majority of such controlling TEs influence the neighboring genes in cis by either promoting or repressing the transcriptional activities. Although TEs are highly repetitive in the genomes and transcribed in specific stress conditions or developmental stages, the trans -acting regulatory roles of TE-derived RNAs have been rarely studied...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29772955/current-trends-and-future-perspectives-in-pelvic-reconstructive-surgery
#4
Mélanie Aubé, Le Mai Tu
Pelvic organ prolapse is a prevalent disorder with a high lifetime incidence of surgical repair. Pelvic organ prolapse surgery has greatly evolved over the past years, and pelvic floor reconstructive surgeons are faced with a vast array of treatment options for their patients. Our review article illustrates the current trends and future perspectives for the surgical treatment of pelvic organ prolapse.
January 2018: Women's Health
https://www.readbyqxmd.com/read/29772715/effects-of-sparassis-crispa-in-medical-therapeutics-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#5
Le Thi Nhu Ngoc, You-Kwan Oh, Young-Jong Lee, Young-Chul Lee
In this study, we investigated the therapeutic potential and medical applications of Sparassis crispa ( S. crispa ) by conducting a systematic review of the existing literature and performing a meta-analysis. The original efficacy treatment of the mushroom extract is considered primarily and searched in electronic databases. A total of 623 articles were assessed, 33 randomized controlled experiments were included after the manual screening, and some papers, review articles, or editorials that did not contain data were excluded...
May 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29772694/the-nf-%C3%AE%C2%BAb-activating-pathways-in-multiple-myeloma
#6
REVIEW
Payel Roy, Uday Aditya Sarkar, Soumen Basak
Multiple myeloma(MM), an incurable plasma cell cancer, represents the second most prevalent hematological malignancy. Deregulated activity of the nuclear factor kappaB (NF-κB) family of transcription factors has been implicated in the pathogenesis of multiple myeloma. Tumor microenvironment-derived cytokines and cancer-associated genetic mutations signal through the canonical as well as the non-canonical arms to activate the NF-κB system in myeloma cells. In fact, frequent engagement of both the NF-κB pathways constitutes a distinguishing characteristic of myeloma...
May 16, 2018: Biomedicines
https://www.readbyqxmd.com/read/29772592/-cardiac-anaesthesia-anaesthesiological-management
#7
Jochen Renner, Berthold Bein, Ole Broch
The anaesthesiological management of patients scheduled for cardiac surgery has been refined distinctively over the last decade due to different reasons. The continuing growth of the elderly patient population and the increasing number of combined cardiac surgery procedures in octogenarians on the one hand are one aspect. The rapid development of minimally invasive cardiac surgery and the enhancements in mechanical, artificial heart assist devices on the other hand can be seen as additional decisive factors...
May 2018: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/29772584/survival-after-aortic-valve-replacement-with-bovine-or-porcine-valve-prostheses-a-systematic-review-and-meta-analysis
#8
Natalie Glaser, Veronica Jackson, Anders Franco-Cereceda, Ulrik Sartipy
BACKGROUND:  Bovine and porcine bioprostheses are commonly used for surgical aortic valve replacement. It is unknown if the long-term survival differs between the two valve types.We performed a systematic review and meta-analysis to compare survival in patients who underwent aortic valve replacement and received a bovine or a porcine prosthesis. METHODS:  We performed a systematic search of Medline, Embase, Web of Science, and the Cochrane Library. Cohort studies that compared survival between patients who underwent aortic valve replacement and received either a bovine or a porcine bioprosthesis and that reported overall long-term survival with hazard ratio (HR) and 95% confidence interval (CI) were included...
May 17, 2018: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29772563/assessment-of-different-pretreatment-technologies-for-efficient-bioconversion-of-lignocellulose-to-ethanol
#9
Jitendra K Singh, Preeti Vyas, Anamika Dubey, Chandrama Prakash Upadhyaya, Richa Kothari, Vineet Veer Tyagi, Ashwani Kumar
The future supply of energy to meet growing energy demand of rapidly exapanding populations is based on wide energy resources, particularly the renewable ones. Among all resources, lignocellulosic biomasses such as agriculture, forest, and agro-industrial residues are the most abundant and easily available bioresource for biorefineries to provide fuels, chemicals, and materials. However, pretreatment of biomass is required to overcome the physical and chemical barriers that exist in the lignin-carbohydrate composite and pretreatment facilitate the entry of biocatalysts for the conversion of biomass into fermentable sugars and other by-products...
June 1, 2018: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/29772540/hsp70-and-gama-semino-protein-as-possible-prognostic-marker-of-prostate-cancer
#10
Sanjay Kumar, Sanjeev Gurshaney, Yori Adagunodo, Erica Gage, Shezreen Qadri, Mahak Sharma, Shalie Malik, Upender Manne, Udai P Singh, Rajesh Singh, Manoj K Mishra
In the United States, Prostate Cancer (PCa) is the leading cause of cancer-related mortality in men. PCa resulted in abnormal growth and function of prostate gland such as secretion of high level of gamma-seminoprotein (gama-SM)/Prostate-Specific Antigen (PSA) which could be detected in the blood. Beside gama-SM protein, the levels of heat shock proteins (Hsp70) were also observed significantly high. Therefore, gama-SM and Hsp70 are unique proteins with high potential for PCa therapeutics and diagnostics. High level of Hsp70 suppresses apoptosis, thus allowing PCa cells to exist; however, depletion of Hsp70 induces apoptosis in PCa cells...
June 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/29772409/lymphatics-in-the-liver
#11
REVIEW
Masatake Tanaka, Yasuko Iwakiri
The liver is the largest lymph producing organ. A significant increase in the number of hepatic lymphatic vessels, or lymphangiogenesis, has been reported in various liver diseases, including, but not limited to, cirrhosis, viral hepatitis and hepatocellular carcinoma. Despite its apparent relevance in healthy and diseased livers as these and other observations indicate, the hepatic lymphatic system has been poorly studied. With knowledge of the lymphatic system in other organs and tissues incorporated, this review article addresses the current knowledge of the hepatic lymphatic system and the potential role of lymphatic endothelial cells in the health and the disease of the liver and concludes with a brief description on future directions of the study of the hepatic lymphatic system...
May 14, 2018: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29772345/autologous-liquid-platelet-rich-fibrin-a-novel-drug-delivery-system
#12
REVIEW
Richard J Miron, Yufeng Zhang
There is currently widespread interest within the biomaterial field to locally deliver biomolecules for bone and cartilage regeneration. Substantial work to date has focused on the potential role of these biomolecules during the healing process, and the carrier system utilized is a key factor in their effectiveness. Platelet rich fibrin (PRF) is a naturally derived fibrin scaffold that is easily obtained from peripheral blood following centrifugation. Slower centrifugation speeds have led to the commercialization of a liquid formulation (liquid-PRF) resulting in an upper plasma layer composed of liquid fibrinogen/thrombin prior to clot formation that remains in its liquid phase for approximately 15 minutes until injected into bodily tissues...
May 14, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29772289/nose-to-brain-drug-delivery-an-update-on-clinical-challenges-and-progress-towards-approval-of-anti-alzheimer-drugs
#13
REVIEW
Mukta Agrawal, Swarnlata Saraf, Shailendra Saraf, Sophia G Antimisiaris, Mahavir Chougule, Sunday A Shoyele, Amit Alexander
According to the Alzheimer Association Report (2017), Alzheimer's disease (AD) is the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the year 2017 itself, the cost of AD treatment in the USA has been reported to rise to $259 billion. This statistic shows the severity of the disease in the USA which is very much similar across the globe. On the other hand, the treatment remains limited to a few conventional oral medications (approved by FDA). These are mainly acting superficially from mild to the moderate AD...
May 14, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29771698/updates-in-colorectal-cancer-screening-in-inflammatory-bowel-disease
#14
William T Clarke, Joseph D Feuerstein
PURPOSE OF REVIEW: This review article will discuss the risk of colorectal cancer (CRC) in patients with inflammatory bowel disease (IBD), as well as the current recommendations for CRC screening and surveillance in patients with ulcerative colitis or Crohn's colitis involving one-third of the colon. RECENT FINDINGS: Given that most cases of CRC are thought to arise from dysplasia, previous guidelines have recommended endoscopic surveillance with random biopsies obtained from all segments of the colon...
May 15, 2018: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/29771223/enabling-physicians-to-lead-canada-s-leads-framework
#15
Graham Dickson, John Van Aerde
Purpose The purpose of this paper is to provide a case study demonstrating that LEADS in a Caring Environment Capabilities Framework in Canada can assist physicians to be partners in leading health reform. Design/methodology/approach A descriptive case-based approach was followed, relying on existing documents, research papers and peer-reviewed articles, to substantiate the effect of LEADS on physician leadership in Canada. Findings The Canadian LEADS framework enables physicians to lead by providing them with access to best practices of leadership, acting as an antidote to fragmented leadership practice, setting standards for development and accountability and providing opportunities for efficient and effective system-wide leadership development and change...
May 8, 2018: Leadership in Health Services
https://www.readbyqxmd.com/read/29770854/german-contribution-to-development-and-innovations-in-the-management-of-acute-myocardial-infarction-and-cardiogenic-shock
#16
REVIEW
Hans-Josef Feistritzer, Steffen Desch, Suzanne de Waha, Alexander Jobs, Uwe Zeymer, Holger Thiele
Treatment of acute coronary syndromes has evolved over time leading to a significantly reduced mortality. Multiple major trials have been performed in Germany leading to new treatment strategies in acute coronary syndromes including cardiogenic shock. This review article will summarize major trials and their impact on guideline recommendations in acute myocardial infarction highlighting reperfusion strategies, antiplatelet regimens, prognosis assessment and also mechanical circulatory support in stable infarction patients and in cardiogenic shock...
May 16, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29769414/clinical-utility-of-arterial-spin-labeling-for-preoperative-grading-of-glioma-a-diagnostic-meta-analysis
#17
Linchen Li, Xinjun Wang, Min Zhang, Yan Zhang
There were obvious differences in biological behavior and prognosis between low-grade glioma and high-grade glioma, it is of great importance for clinicians to make a right judgement for preoperative grading. We conducted a comprehensive meta-analysis to evaluate the clinical utility of arterial spin labeling for preoperative grading. We searched the PubMed, Embase, China National Knowledge Infrastructure, and Weipu electronic databases for articles published through November 10, 2017 and used "arterial spin-labeling" OR "ASL perfusion, grading" OR "differentiation, glioma" OR "glial tumor, diagnostic test" as the search terms...
May 16, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29768930/a-strategic-planning-tool-for-increasing-african-american-blood-donation
#18
Ashley Singleton, Regena Spratling
Historically, African Americans (AAs) have been underrepresented as blood donors. Having a lack of racially diverse blood donors contributes to transfusion complications, particularly in patients with sickle cell disease, who are both disproportionately AA and the recipients of frequent transfusions. Increasing AA blood donation is a complex public health issue. This review article serves to fill a gap in translating research regarding known hindrances and facilitators of AA blood donation to improve real-world donation practice and ultimately, patient outcomes...
May 1, 2018: Health Promotion Practice
https://www.readbyqxmd.com/read/29768475/conjugated-equine-estrogen-and-medroxyprogesterone-acetate-are-associated-with-decreased-risk-of-breast-cancer-relative-to-bioidentical-hormone-therapy-and-controls
#19
Zexian Zeng, Xia Jiang, Xiaoyu Li, Alan Wells, Yuan Luo, Richard Neapolitan
OBJECTIVE: By the 1990s it became popular for women to use hormone therapy (HT) to ease menopause symptoms. Bioidentical estrogen and progesterone are supplements whose molecular structures are identical to what is made in the human body, while synthetic supplements are ones whose structures are not. After the Women's Health Initiative found that the combined use of the synthetics conjugated equine estrogen (CEE) and medroxyprogesterone acetate (MPA) increased breast cancer risk, prescriptions for synthetic HT declined considerably...
2018: PloS One
https://www.readbyqxmd.com/read/29767819/is-there-a-prospect-for-hybrid-aortic-arch-surgery
#20
REVIEW
Mohamad Bashir, Amer Harky, Haris Bilal
The surge of endovascular repair of aortic aneurysm in current modern aortic surgery practice has been the key for surgical management of elective cases of thoracic aortic aneurysms. This has paved way for the combined hybrid approach to be amongst the armamentarium for the management of aortic arch disease. The pivotal understanding of the aortic arch natural history coupled with device technology advancement allowed surgeons insight into delivery of hybrid surgery with acceptable morbidity and mortality results...
May 16, 2018: General Thoracic and Cardiovascular Surgery
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