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fertility and sterility

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https://www.readbyqxmd.com/read/28818972/fertile-offspring-from-sterile-sex-chromosome-trisomic-mice
#1
Takayuki Hirota, Hiroshi Ohta, Benjamin E Powell, Shantha K Mahadevaiah, Obah A Ojarikre, Mitinori Saitou, James M A Turner
Having the correct number of chromosomes is vital for normal development and health. Sex chromosome trisomy (SCT) affects 0.1% of the human population and is associated with infertility. We show that during reprogramming to induced pluripotent stem cells (iPSC), fibroblasts from sterile trisomic XXY and XYY mice lose the extra sex chromosome, by a phenomenon we term trisomy-biased chromosome loss (TCL). Resulting euploid XY iPSCs can be differentiated into the male germ cell lineage and functional sperm that can be used in intracytoplasmic sperm injection to produce chromosomally normal, fertile offspring...
August 17, 2017: Science
https://www.readbyqxmd.com/read/28817594/soil-pathogen-aphid-interactions-under-differences-in-soil-organic-matter-and-mineral-fertilizer
#2
Stijn van Gils, Giovanni Tamburini, Lorenzo Marini, Arjen Biere, Maaike van Agtmaal, Olaf Tyc, Martine Kos, David Kleijn, Wim H van der Putten
There is increasing evidence showing that microbes can influence plant-insect interactions. In addition, various studies have shown that aboveground pathogens can alter the interactions between plants and insects. However, little is known about the role of soil-borne pathogens in plant-insect interactions. It is also not known how environmental conditions, that steer the performance of soil-borne pathogens, might influence these microbe-plant-insect interactions. Here, we studied effects of the soil-borne pathogen Rhizoctonia solani on aphids (Sitobion avenae) using wheat (Triticum aestivum) as a host...
2017: PloS One
https://www.readbyqxmd.com/read/28816593/elucidating-the-role-of-wrky27-in-male-sterility-in-arabidopsis
#3
M Shahid Mukhtar, Xiaoyu Liu, Imre E Somssich
The WRKY proteins belong to a superfamily of TFs that play pivotal roles in responses to a wide range of biotic, abiotic, developmental and physiological cues. Here, we assayed the accumulation of basal WRKY27 transcripts in diverse tissue including root, shoot, leaf and flowers. We demonstrated that plants over-expressing WRKY27 transcript levels exhibit growth aberrations and fertility defects. Scanning electron microscopic data suggest that WRKY27 overexpressor plants exhibit pollen dehiscence defects. Our fluorescein diacetate hydrolysis assay showed that flowers of plants overexpressing WRKY27 display significantly decreased pollen viability...
August 17, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/28815278/phenotypic-genetic-and-molecular-characterization-of-7b-1-a-conditional-male-sterile-mutant-in-tomato
#4
Anna Pucci, Maurizio Enea Picarella, Andrea Mazzucato
We characterized the photoperiod-sensitive 7B - 1 male-sterile mutant in tomato, showing its allelism with stamenless - 2 . Mapping experiments indicated SlGLO2 , a B-class MADS-box family member, as a strong candidate to underlie the 7B - 1 mutation. The interest in male sterility (MS) dates back to a long time due to its perspective use in hybrid seed production. Here, we characterize 7B-1, a photoperiod-sensitive male-sterile (ms) mutant in tomato (Solanum lycopersicum L.), in which stamens are restored to fertility by permissive growth conditions in short days (SD)...
August 16, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28805257/three-representative-inter-and-intra-subspecific-crosses-reveal-the-genetic-architecture-of-reproductive-isolation-in-rice
#5
Guangwei Li, Xiaoting Li, Yuan Wang, Jiaming Mi, Feng Xing, Dahan Zhang, Qiyan Dong, Xianghua Li, Jinghua Xiao, Qifa Zhang, Yidan Ouyang
Systematic characterization of genetic and molecular mechanisms in formation of hybrid sterility is of fundamental importance in understanding reproductive isolation and speciation. Using ultra-high-density genetic maps, 43 single-locus QTLs and 223 digenic interactions for embryo-sac, pollen, and spikelet fertility are depicted from three crosses between representative varieties of japonica and two varietal groups of indica, which provide an extensive archive for investigating the genetic basis of reproductive isolation in rice...
August 14, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28801781/acute-pain-crisis-in-a-patient-with-sickle-cell-disease-undergoing-ovarian-simulation-for-fertility-preservation-prior-to-curative-stem-cell-transplantation-case-report-and-literature-review
#6
Michelle Matthews, Rebecca Pollack
PURPOSE: Hematopoietic stem cell transplantation (HSCT) is a cure for sickle cell disease (SCD) but frequently results in permanent sterility. The complications associated with oocyte cryopreservation and risks of future pregnancy are increased in SCD patients. This case report discusses risk reduction strategies and includes a literature review of pregnancy after HSCT. CASE: A 23-year-old woman underwent ovarian stimulation for fertility preservation resulting in cancelation due to acute pain crisis...
August 11, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28797084/the-endogenous-transposable-element-tgm9-is-suitable-for-generating-knockout-mutants-for-functional-analyses-of-soybean-genes-and-genetic-improvement-in-soybean
#7
Devinder Sandhu, Jayadri Ghosh, Callie Johnson, Jordan Baumbach, Eric Baumert, Tyler Cina, David Grant, Reid G Palmer, Madan K Bhattacharyya
In soybean, variegated flowers can be caused by somatic excision of the CACTA-type transposable element Tgm9 from Intron 2 of the DFR2 gene encoding dihydroflavonol-4-reductase of the anthocyanin pigment biosynthetic pathway. DFR2 was mapped to the W4 locus, where the allele containing Tgm9 was termed w4-m. In this study we have demonstrated that previously identified morphological mutants (three chlorophyll deficient mutants, one male sterile-female fertile mutant, and three partial female sterile mutants) were caused by insertion of Tgm9 following its excision from DFR2...
2017: PloS One
https://www.readbyqxmd.com/read/28791615/molecular-approaches-for-manipulating-male-sterility-and-strategies-for-fertility-restoration-in-plants
#8
REVIEW
Pawan Shukla, Naveen Kumar Singh, Ranjana Gautam, Israr Ahmed, Deepanker Yadav, Akanksha Sharma, Pulugurtha Bharadwaja Kirti
Usable pollination control systems have proven to be effective system for the development of hybrid crop varieties, which are important for optimal performance over varied environments and years. They also act as a biocontainment to check horizontal transgene flow. In the last two decades, many genetic manipulations involving genes controlling the production of cytotoxic products, conditional male sterility, altering metabolic processes, post-transcriptional gene silencing, RNA editing and chloroplast engineering methods have been used to develop a proper pollination control system...
August 8, 2017: Molecular Biotechnology
https://www.readbyqxmd.com/read/28768824/aladin-is-required-for-the-production-of-fertile-mouse-oocytes
#9
Sara Carvalhal, Michelle Stevense, Katrin Koehler, Ronald Naumann, Angela Huebner, Rolf Jessberger, Eric R Griffis
Asymmetric cell divisions depend upon the precise placement of the spindle apparatus. In mammalian oocytes, spindles assemble close to the cell's center but chromosome segregation takes place at the cell periphery where half of the chromosomes are expelled into small, non-developing polar bodies at anaphase. By dividing so asymmetrically, most of the cytoplasmic content within the oocyte is preserved, which is critical for successful fertilization and early development. Recently, we determined that the nucleoporin ALADIN participates in spindle assembly in somatic cells, and we have also shown that female mice homozygously null for ALADIN are sterile...
August 2, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28766472/stereological-analysis-of-gonads-from-diploid-and-triploid-fish-yellowtail-tetra-astyanax-altiparanae-garutti-britski-in-laboratory-conditions
#10
Nivaldo Ferreira do Nascimento, Diógenes Henrique de Siqueira-Silva, Matheus Pereira-Santos, Takafumi Fujimoto, José Augusto Senhorini, Laura Satiko Okada Nakaghi, George Shigueki Yasui
This study aimed to examine the gonadal morphology of diploid and triploid fish through stereological analysis. Triploid individuals were obtained after temperature shock (40°C for 2 min) at 2 min post-fertilization and reared until 175 days post-fertilization (dpf). Intact eggs were used to obtain the diploids. Gonads were collected for histological analysis at 83, 114, 144 and 175 dpf. Diploid females and males presented normal oogenesis and spermatogenesis through all the experimental period. Conversely, stereological analysis revealed that triploid females were sterile and oogonia were the prevalent cell type in the ovaries...
August 2, 2017: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/28764642/the-susceptibility-of-fshb-211g%C3%A2-%C3%A2-t-and-fshr-g-29a-919a%C3%A2-%C3%A2-g-2039a%C3%A2-%C3%A2-g-polymorphisms-to-men-infertility-an-association-study-and-meta-analysis
#11
Qiuyue Wu, Jing Zhang, Peiran Zhu, Weijun Jiang, Shuaimei Liu, Mengxia Ni, Mingchao Zhang, Weiwei Li, Qing Zhou, Yingxia Cui, Xinyi Xia
BACKGROUND: Male infertility is a complex disorder caused by genetic, developmental, endocrine, or environmental factors as well as unknown etiology. Polymorphisms in the follicle stimulating hormone beta subunit (FSHB) (rs10835638, c.-211G > T) and follicle stimulating hormone receptor (FSHR) (rs1394205, c.-29G > A; rs6165, c.919A > G; rs6166, c.2039 A > G) genes might disturb normal spermatogenesis and affect male reproductive ability. METHODS: To further ascertain the aforementioned effects, we conducted a case-control study of 255 infertile men and 340 fertile controls from South China using the Mass ARRAY method, which was analyzed by the t-tests and logistic regression analysis using SPSS for Windows 14...
August 1, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28757140/the-feasibility-safety-and-effectiveness-of-hysteroscopic-sterilization-compared-with-laparoscopic-sterilization
#12
Lina Antoun, Paul Smith, Janesh K Gupta, T Justin Clark
BACKGROUND: In contrast to conventional laparoscopic sterilization, newer hysteroscopic approaches avoid the need for hospital admission, general anesthesia, and prolonged recovery. However, there are concerns that the feasibility, safety, and efficacy of hysteroscopic sterilization may be lower than established laparoscopic sterilization. OBJECTIVE: We sought to evaluate the outcomes of hysteroscopic sterilization compared with laparoscopic sterilization in routine clinical practice in a comparative observational cohort study...
July 27, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28755693/laboratory-evaluation-on-a-potential-birth-control-diet-for-fruit-fly-sterile-insect-technique-sit
#13
Chiou Ling Chang
Sterile insect technique (SIT) is one of the most effective fruit fly control technologies. Irradiation has been used to sterilize male fruit flies before release to the field to compete with the wild males for females. Imagine an environmental and cost effective method using a rearing diet that can make insects sterile indefinitely, by feeding for 7days before release. This could replace costly irradiation process. A potential birth control diet was evaluated on fertility, mating, survival, and protein analysis for fruit fly species in Hawaii...
August 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/28733712/fertility-and-ploidy-of-gametes-of-allodiploid-and-allotriploid-loaches-produced-by-diploid-misgurnus-anguillicaudatus-females-and-paramisgurnus-dabryanus-males
#14
Songqian Huang, Xiaojuan Cao, Weimin Wang, Mona Nasr
Artificial and natural hybridization of dojo loach Misgurnus anguillicaudatus (2N = 50, DD for short) and large-scale loach Paramisgurnus dabryanus (2N = 48, PP for short) are well-grown. However, these hybrid loaches have not yet been examined for fertility and ploidy of gametes. Here, histological observations, artificial propagation, observations of embryonic development, larval morphology, and ploidy analyses were conducted to determine the fertility and ploidy of gametes of allodiploid (DP for short) and allotriploid (DDP for short) loaches, produced by DD females × PP males and induced from fertilized eggs of DD females × PP males by cold shock to prevent the second polar body release, respectively...
July 21, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28732077/mutations-in-the-caenorhabditis-elegans-orthologs-of-human-genes-required-for-mitochondrial-trna-modification-cause-similar-electron-transport-chain-defects-but-different-nuclear-responses
#15
Carmen Navarro-González, Ismaïl Moukadiri, Magda Villarroya, Ernesto López-Pascual, Simon Tuck, M-Eugenia Armengod
Several oxidative phosphorylation (OXPHOS) diseases are caused by defects in the post-transcriptional modification of mitochondrial tRNAs (mt-tRNAs). Mutations in MTO1 or GTPBP3 impair the modification of the wobble uridine at position 5 of the pyrimidine ring and cause heart failure. Mutations in TRMU affect modification at position 2 and cause liver disease. Presently, the molecular basis of the diseases and why mutations in the different genes lead to such different clinical symptoms is poorly understood...
July 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28724622/transcription-factor-myb26-is-key-to-spatial-specificity-in-anther-secondary-thickening-formation
#16
Caiyun Yang, Jie Song, Alison Ferguson, Doris Klisch, Kim Simpson, Rui Mo, Benjamin Taylor, Zoe A Wilson
Successful fertilisation relies on the production and effective release of viable pollen. Failure of anther opening (dehiscence), results in male sterility although the pollen may be fully functional. MYB26 regulates the formation of secondary thickening in the anther endothecium, which is critical for anther dehiscence and fertility. Here we show that the although the MYB26 transcript shows expression in multiple floral organs the MYB26 protein is localised specifically to the anther endothecium nuclei and that it directly regulates two NAC domain genes, NST1 and NST2, which are critical for the induction of secondary thickening biosynthesis genes...
July 19, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28712045/dynamics-of-soil-bacterial-communities-over-a-vegetation-season-relate-to-both-soil-nutrient-status-and-plant-growth-phenology
#17
Davide Francioli, Elke Schulz, François Buscot, Thomas Reitz
Soil microorganisms regulate element cycling and plant nutrition, mediate co-existence of neighbors, and stabilize plant communities. Many of these effects are dependent upon environmental conditions and, in particular, on nutrient quality and availability in soils. In this context, we set up a pot experiment in order to examine the combined effects of soil nutrient availability and microbial communities on plant-soil interactions and to investigate assemblage rules for soil bacterial communities under changed nutrient conditions...
July 15, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28706525/functional-marker-assisted-improvement-of-stable-cytoplasmic-male-sterile-lines-of-rice-for-bacterial-blight-resistance
#18
Jegadeesan Ramalingam, Palanisamy Savitha, Ganesh Alagarasan, Ramasamy Saraswathi, Ranganathan Chandrababu
Bacterial blight (BB), caused by Xanthomonas oryzae pv.oryzae is one among the major diseases in rice, which in severe condition cause losses up to 60% in total yield. Marker assisted pyramiding of three broad spectrum BB resistance genes (xa5, xa13, and Xa21) in prominent rice varieties is the most economical and effective strategy for the management of the BB disease. We report here the pyramiding of three genes (xa5, xa13, and Xa21) in maintainer lines (CO 2B, CO 23B, and CO 24B) of three promising wild abortive cytoplasmic male sterile lines (CO 2A, CO 23A, and CO 24A) through functional markers assisted back cross breeding...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28694258/plc%C3%AE-is-the-physiological-trigger-of-the-ca-2-oscillations-that-induce-embryogenesis-in-mammals-but-conception-can-occur-in-its-absence
#19
Alaa Hachem, Jonathan Godwin, Margarida Ruas, Hoi Chang Lee, Minerva Ferrer Buitrago, Goli Ardestani, Andrew Bassett, Sebastian Fox, Felipe Navarrete, Petra de Sutter, Björn Heindryckx, Rafael Fissore, John Parrington
Activation of the egg by the sperm is the first, vital stage of embryogenesis. The sperm protein PLCζ has been proposed as the physiological agent that triggers the Ca(2+) oscillations that normally initiate embryogenesis. Consistent with this, recombinant PLCζ induces Ca(2+) oscillations in eggs and debilitating mutations in the PLCZ1 gene are associated with infertility in men. However, there has been no evidence that knockout of the gene encoding PLCζ abolishes the ability of sperm to induce Ca(2+) oscillations in eggs...
August 15, 2017: Development
https://www.readbyqxmd.com/read/28689229/detection-of-candidate-nectin-gene-mutations-in-infertile-men-with-severe-teratospermia
#20
Richard Bronson, Anatoly Mikhailik, John Schwedes, Dimitri Gnatenko, Eli Hatchwell
PURPOSE: Approximately 40% of infertile men have an abnormal semen analysis, resulting from either abnormalities of sperm production (defective spermatogenesis) or sperm shape (defective spermiogenesis). This latter process is dependent upon the function of Sertoli cells, which maintain specialized junctional complexes with germ cells. Nectins, members of the immunoglobulin superfamily, participate in formation of these dynamic complexes. Male mice in which the nectin-2 or nectin-3 gene is knocked out are sterile...
July 8, 2017: Journal of Assisted Reproduction and Genetics
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