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https://www.readbyqxmd.com/read/29236228/population-pharmacokinetic-pharmacodynamic-modeling-of-ropivacaine-in-spinal-anesthesia
#1
Zoubir Djerada, Catherine Feliu, Yoann Cazaubon, Faouzi Smati, Philippe Gomis, Dominique Guerrot, Beny Charbit, Olivier Fernandes, Jean-Marc Malinovsky
BACKGROUND: Ropivacaine is frequently used in spinal anesthesia but the relationship between plasma concentrations and sensory block level remains unknown. OBJECTIVE: The aim of this study was to assess the relationship between plasma ropivacaine concentrations and effects during spinal anesthesia. METHODS: Sixty patients aged between 18 and 82 years were included in this study after providing written informed consent. Patients were randomly assigned to receive intrathecal administration of ropivacaine 15, 20 or 25 mg...
December 13, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29235305/-discussion-on-related-problems-of-model-species-of-fungus%C3%AF-paecilomyces-hepialid
#2
Ru-Qin Dai, Chong-Yao Shen, Xiao-Ming Li, Jiang-Li Lan, Shu-Fang Lin, Ai-Juan Shao
Paecilomyces hepiali is a new species of fungus isolated from a field collection of Ophiocordyceps sinensis from Baima snow mountain, Diqing Tibetan Autonomous Prefecture, Yunnan Province by the Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences. The specimen was identified and named as Paecilomyces hepiali by Qing-Tao Chen, the professor of the Institute of Microbiology, Chinese Academy of Sciences (Paecilomyces hepiali) (2008), who identified a dried culture of living strain 82-2 as the holotype...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29235304/-exploration-and-thoughts-about-zoological-origin-and-macroscopical-identification-of-chinese-material-medica-haima-in-china-pharmacopoeia
#3
Chao Jiang, Feng Shan, Yuan Yuan, Fu-Yan Liu, Zhi-Lai Zhan, Yan Jin, Yu-Yang Zhao, Lu-Qi Huang
"Haima" (Hippocampus) has a long history in China as an important traditional animal medicine, but many closely-related members of the Hippocampus genus are also used as Haima in particular regions. To investigate the real origin of "Haima", a herbalogical studies, particularly inpictures and photographs of the ancient literature are corroborated with seahorse specimens in museum, we confirm Chinese material medica "Haima" in China Pharmacopoeia is origin from H. kelloggi, 1901, H.spinosissimus, 1913, H. kuda, 1852, H...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29234415/1h-nmr-based-serum-metabolomics-study-to-investigate-hepatoprotective-effect-of-qin-jiao-on-carbon-tetrachloride-induced-acute-hepatotoxicity-in-rats
#4
Zeyun Li, Ying Li, Lingpan Lu, Zhiheng Yang, Wenhua Xue, Xin Tian, Xiaojian Zhang
Gentiana macrophylla Radix, commonly known as Qin-Jiao (QJ), was recorded alone to treat jaundice in Compendium of Materia Medica and has been frequently prescribed for treatment of liver disease in China. However, the underlying mechanism remains unknown. In the present work, QJ of 1,2 g/kg or silybin of 40 mg/kg (positive control) was orally given to rats for 7 days to verify the protective effect on acute liver damage induced by tetrachloride (CCl4). Together with serum biochemistry and histopathological examination, 1H-NMR based metabolomics work was carried out to investigate the efficacy...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29229459/regenerative-endodontic-procedures-among-endodontists-a-web-based-survey
#5
Jonathan Y Lee, Daniel D Kersten, Pete Mines, Thomas A Beltran
INTRODUCTION: The protocols that endodontists implement for regenerative endodontic procedures (REPs) are unknown. The aim of this study was to examine current REP protocols among practicing endodontists in the United States. METHODS: A Web-based survey was sent to 4060 active members of the American Association of Endodontists (AAE). A total of 850 participants completed the survey, representing a 20.9% response rate. RESULTS: Responses indicated 60% reported having performed REPs; most performed 1 to 3 per year...
December 8, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29229073/disinfection-of-dentinal-tubules-with-2-chlorhexidine-gel-calcium-hydroxide-and-herbal-intracanal-medicaments-against-enterococcus-faecalis-an-in-vitro-study
#6
Agrima Vasudeva, Dakshita Joy Sinha, Shashi Prabha Tyagi, Narendra Nath Singh, Paridhi Garg, Deepti Upadhyay
AIM: This in vitro study was conducted to evaluate the disinfection of dentinal tubules using 2% Chlorhexidine gel, Honey, Aloe vera gel, Curcuma longa, Propolis gel and Calcium hydroxide against Enterococcus faecalis. MATERIALS AND METHOD: Two hundred and ten human mandibular first premolars were infected with Enterococcus faecalis for 21 days. Samples were divided into 7 groups. Group I- Saline (negative control), Group II- 2% Chlorhexidine gel(CHX), Group III- honey, Group IV- Aloe vera gel, Group V- 20% Curcuma longa gel, Group VI- Propolis gel and Group VII -Calcium hydroxide (CH)...
December 2017: Singapore Dental Journal
https://www.readbyqxmd.com/read/29228264/co-invading-symbiotic-mutualists-of-medicago-polymorpha-retain-high-ancestral-diversity-and-contain-diverse-accessory-genomes
#7
Stephanie S Porter, Joshua J Faber-Hammond, Maren L Friesen
Exotic, invasive plants and animals can wreak havoc on ecosystems by displacing natives and altering environmental conditions. However, much less is known about the identities or evolutionary dynamics of the symbiotic microbes that accompany invasive species. Most leguminous plants rely upon symbiotic rhizobium bacteria to fix nitrogen, and are incapable of colonizing areas devoid of compatible rhizobia. We compare the genomes of symbiotic rhizobia in a portion of the legume's invaded range, with those of the rhizobium symbionts from across the legume's native range...
December 6, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29227273/-poisoning-by-psychopharmacological-drugs-in-azerbaijan-the-results-of-8-year-prospective-observation
#8
I Afandiyev, V Azizov
Acute poisoning of chemical etiology is a significant global public health problem. The aim of this study was the analysis of the toxicoepidemiological structure of psychopharmacological drugs poisoning in Azerbaijan. We collected and analyzed the data on all cases of acute poisoning by psychopharmacological drugs (codes of categories T42/T43 ICD-10) undergoing inpatient treatment at the Center of Clinical Toxicology in Baku, Azerbaijan in 2009-2016. The total number of patients with acute intoxication by psychopharmacological drugs was 3,413, which was 48...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29218930/-herbal-textual-research-on-origins-of-chonglou
#9
Lu Jiang, Li-Ping Kang, Da-Hui Liu, Hua-Sheng Peng, Jin Xie, Min Chen
Based on the field investigation, this paper researched the germplasms and geoherbs habitat of Chonglou in ancient herbal books systematically. The results showed that, Chonglou in ancient herbal books sometimes referred to certain specific germplasm, while sometimes it referred to many species derived from genus Paris except Sect. Paris. The medicinal material Chonglou in Chinese Materia Medica Bencaotujing and Bencaomengquan was verified as P. polyphylla var. chinensis, which could be P. polyphylla in Xinxiubencao, and it should include P...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29218437/d-lactic-acidosis-in-humans-systematic-literature-review
#10
Davide G A M Bianchetti, Giacomo S Amelio, Sebastiano A G Lava, Mario G Bianchetti, Giacomo D Simonetti, Carlo Agostoni, Emilio F Fossali, Gregorio P Milani
BACKGROUND: D-lactic acidosis is an uncommon and challenging form of metabolic acidosis that may develop in short bowel syndrome. It has been documented exclusively in case reports and small case series. METHODS: We performed a review of the literature in the National Library of Medicine and Excerpta Medica databases. RESULTS: We identified 84 original reports published between 1977 and 2017. D-lactic acidosis was observed in 98 individuals ranging in age from 7 months to 86 years with short bowel syndrome...
December 7, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29209521/management-of-patients-with-end-stage-renal-disease-undergoing-chemotherapy-recommendations-of-the-associazione-italiana-di-oncologia-medica-aiom-and-the-societ%C3%A3-italiana-di-nefrologia-sin
#11
Paolo Pedrazzoli, Nicola Silvestris, Antonio Santoro, Simona Secondino, Oronzo Brunetti, Vito Longo, Elena Mancini, Sara Mariucci, Teresa Rampino, Sara Delfanti, Silvia Brugnatelli, Saverio Cinieri
Background: The overall risk of some cancers is increased in patients receiving regular dialysis treatment due to chronic oxidative stress, a weakened immune system and enhanced genomic damage. These patients could benefit from the same antineoplastic treatment delivered to patients with normal renal function, but a better risk/benefit ratio could be achieved by establishing specific guidelines. Key considerations are which chemotherapeutic agent to use, adjustment of dosages and timing of dialysis in relation to the administration of chemotherapy...
2017: ESMO Open
https://www.readbyqxmd.com/read/29208035/prevalence-predictors-and-adverse-outcomes-of-adolescent-pregnancy-in-sub-saharan-africa-a-protocol-of-a-systematic-review
#12
Carlson-Babila Sama, Stewart Ndutard Ngasa, Bonaventure Suiru Dzekem, Simeon-Pierre Choukem
BACKGROUND: Several studies have reported on factors influencing adolescent pregnancies and the associated outcomes, but evidence from a systematic review is limited, especially in sub-Saharan Africa where the greater burden lies. Establishment of accurate epidemiological data on the rates of adolescent pregnancy, its predictors, and adverse outcomes (maternal and neonatal) may have important implications towards attainment of the Sustainable Development Goals. METHODS: This will be a systematic review of studies reporting predictors of adolescent pregnancy and adverse outcomes in sub-Saharan Africa published between January 2000 and December 2017...
December 6, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29206820/-general-practitioner-certification
#13
José Adrián Rojas-Dosal
La regulación de la profesión médica es un proceso antiguo en nuestro país. Desde los tiempos del virreinato existía el Real Tribunal del Protomedicato, que tenía como función examinar a los médicos, cirujanos y boticarios para ser autorizados a ejercer su profesión; con el tiempo, esta función se fue relegando en otras estructuras administrativas que se fueron modificando, pero que la mantuvieron en vigor.
November 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/29206010/regulation-circulation-and-distribution-of-penicillin-in-portugal-1944-1954
#14
Victoria Bell, João Rui Pita, Ana Leonor Pereira
Portugal did not participate in World War II but was one of the first countries in the world to receive penicillin for civilian use. The Portuguese Red Cross began to import the antibiotic from the United States of America in 1944 and appointed a controlling committee to oversee its distribution, due to the small amount available. In 1945, as world production increased, penicillin began to be distributed through the normal channels. An important role in its regulation was played by the official department responsible for controlling pharmaceutical and chemical products in Portugal, the Comissão Reguladora dos Produtos Químicos e Farmacêuticos (Regulatory Committee for Chemical and Pharmaceutical Products)...
2017: Dynamis
https://www.readbyqxmd.com/read/29203459/mobile-phone-apps-for-quality-of-life-and-well-being-assessment-in-breast-and-prostate-cancer-patients-systematic-review
#15
REVIEW
Esther Rincon, Francisco Monteiro-Guerra, Octavio Rivera-Romero, Enrique Dorronzoro-Zubiete, Carlos Luis Sanchez-Bocanegra, Elia Gabarron
BACKGROUND: Mobile phone health apps are increasingly gaining attention in oncological care as potential tools for supporting cancer patients. Although the number of publications and health apps focusing on cancer is increasing, there are still few specifically designed for the most prevalent cancers diagnosed: breast and prostate cancers. There is a need to review the effect of these apps on breast and prostate cancer patients' quality of life (QoL) and well-being. OBJECTIVE: The purposes of this study were to review the scientific literature on mobile phone apps targeting breast or prostate cancer patients and involving QoL and well-being (anxiety and depression symptoms) and analyze the clinical and technological characteristics, strengths, and weaknesses of these apps, as well as patients' user experience with them...
December 4, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29199062/nanoemulsion-as-pharmaceutical-carrier-for-dermal-and-transdermal-drug-delivery-formulation-development-stability-issues-basic-considerations-and-applications
#16
REVIEW
Vineet Kumar Rai, Nidhi Mishra, Kuldeep Singh Yadav, Narayan Prasad Yadav
The use of nanoemulsion in augmenting dermal and transdermal effectiveness of drugs has now well established. The development of nanoemulsion based semisolid dosage forms is an active area of present research. However, thickening or liquid-to-semisolid conversion of the nanoemulsions provides opportunities to the formulation scientist to explore novel means of solving instability issues during transformation. Extending knowledge about the explicit role of nature/magnitude of zeta potential, types of emulsifiers and selection of appropriate semisolid bases could place these versatile carriers from laboratory to industrial scale...
November 30, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29198875/gancao-gansui-combination-impacts-gut-microbiota-diversity-and-related-metabolic-functions
#17
Jingao Yu, Jianming Guo, Weiwei Tao, Pei Liu, Erxin Shang, Zhenhua Zhu, Xiuhe Fan, Juan Shen, Yongqing Hua, Kevin Yue Zhu, Yuping Tang, Jin-Ao Duan
ETHNOPHARMACOLOGICAL RELEVANCE: The theory of "eighteen incompatible medicaments" (EIM) in traditional Chinese medicine (TCM) is the most representative case of herbal-herbal interactions. Gancao and Gansui are one of the incompatible herbal pairs in EIM. Gancao, also known as "licorice", is the most frequently used Chinese herb or food additive. Gansui, the root of Euphorbia kansui T.P. Wang, is another famous Chinese herb usually used to treat edema, ascites and asthma but could induce gastrointestinal (GI) tract irritation...
November 30, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29190858/-the-revista-m%C3%A3-dica-del-imss-in-the-2017-healthcare-book-fair
#18
Manuel Ramiro-H, L Acosta-Pérez, J E Cruz-Aranda, J J García-Damián, R Miguel-Reyes, R González-Martínez
On August, the second edition of the Healthcare Book Fair took place, sponsored by the Facultad de Medicina of UNAM. Again, the Revista Médica del Instituto Mexicano del Seguro Social participated with a stand where we promoted it, talked about the different indexes where our journal is included, explained its objective and scope, and finally talked about its nature as an open access journal, which is aimed to the clinical staff of the different health institutions of our country.
November 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29181844/comparative-efficacy-of-endodontic-medicaments-sodium-hypochlorite-against-enterococcus-faecalis-biofilms
#19
Barbara Plutzer, Peter Zilm, Jithendra Ratnayake, Peter Cathro
BACKGROUND: Many studies have investigated the effectiveness of root canal irrigants and medicaments against Enterococcus faecalis. The aim was to compare the efficacy of commonly used medicaments against Enterococcus faecalis cultured as a biofilm on dentine substrate. METHOD: An E. faecalis biofilm was established on human dentine slices using a continuous flow cell. Each test medicament (Ledermix, Ca(OH)2 , Odontoposte, 0.2% chlorohexidine and 50:50 combinations of Ledermix/Ca(OH)2 and Odontopaste/ Ca(OH)2 ) was introduced into the flow cell and biofilms were harvested and quantitated by determining cellular protein...
November 27, 2017: Australian Dental Journal
https://www.readbyqxmd.com/read/29179355/use-of-vital-pulp-therapies-in-primary-teeth-with-deep-caries-lesions
#20
(no author information available yet)
PURPOSE: This manuscript presents evidence-based guidance on the use of vital pulp therapies for treatment of deep caries lesions in children. A guideline panel convened by the American Academy of Pediatric Dentistry formulated evidence-based recommendations on three vital pulp therapies: indirect pulp treatment (IPT; also known as indirect pulp cap), direct pulp cap (DPC), and pulpotomy. METHODS: The basis of the guideline's recommendations was evidence from "Primary Tooth Vital Pulp Therapy: A Systematic Review and Meta-Analysis...
September 15, 2017: Pediatric Dentistry
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