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https://www.readbyqxmd.com/read/29791174/-drug-and-herbal-hepatotoxicity-an-overview-of-clinical-classifications
#1
Mária Szántová, Jozef Sedlačko, Martina Jakabovičová
Drug induced liver injury (DILI) is often underdiagnosed disease with increasing incidence. In developed countries it belongs to the leading causes of acute liver failure. Risk groups are women and persons older than 60 years. The work summarizes the up to date information on diagnosis and mostly used classifications on DILI. It is quite often and serious complication of medicament therapy. DILI belongs to the most often cause of acute hepatic failure in the old age in developed countries. Diagnostic procedure includes medical history (time correlation with drug intake), clinical symptoms and blood tests...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29790476/-erratum-to-translation-and-validation-of-the-four-scale-for-children-and-its-use-as-outcome-predictor-a-pilot-study
#2
Sofia Simões Ferreira, Daniel Meireles, Alexandra Pinto, Francisco Abecasis
The article "Translation and Validation of the FOUR Scale for Children and its Use as Outcome Predictor: A Pilot Study", published by Acta Médica Portuguesa on September 2017 [Acta Med Port 2017 Sep;30(9):599-607] exhibited the mistake detailed here below: On page 600, paragrapah 4, where it reads: "(...) only the last two are assessed by the GCS and depth of coma may not be accurately detected.4" It should read: "(…) GCS does not include important indicators for an adequate evaluation of coma severity, that is, it only evaluates the cortical function, not including brainstem function evaluation parameters such as respiratory pattern, pupil size and reflexes, nor eye movements; as such it may not detect the coma depth properly...
March 29, 2018: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29783275/assessment-of-likelihood-ratio-for-four-contact-dermatitis-symptoms-of-vinca-minor
#3
Suman Bagchi, Chaturbhuja Nayak, Lex Rutten, Munmun Koley, Subhranil Saha, Mousumi Roy, Sk Jahir Abbas, Simantini Ghosh, Suman Halder, Ghulam Nabi Wani, Anaitulah Ahmad Mir, Showket Ahmad Bhat
BACKGROUND:  Contact dermatitis (CD) is a frequently occurring medical condition, for which Vinca minor (VM) is one of the recommended homeopathic medicines. However, the symptoms indicating this medicine have not yet been assessed systematically. Likelihood ratio (LR), based on Bayesian statistics, may yield better estimation of a medicine's indication than the existing method of entry of symptoms into materia medica and repertories. METHODS:  We investigated LRs of four CD symptoms of VM: (1) great sensitiveness of skin, with redness and soreness from slightest rubbing; (2) weeping eczema with foul, thick crusts; (3) itching amelioration in open air; and (4) CD of scalp...
May 21, 2018: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/29772270/identification-of-certain-panax-species-to-be-potential-substitutes-for-panax-notoginseng-in-hemostatic-treatments
#4
REVIEW
Bin Rui Yang, Sze Chung Yuen, Guang Yi Fan, Wei-Hong Cong, Siu-Wai Leung, Simon Ming-Yuen Lee
Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow (P. notoginseng) is a highly valued Chinese materia medica having a hemostatic effect and mainly used for the treatment of trauma and ischemic cardiovascular diseases. Stringent growth requirements, weak resistance to insect pests and plant diseases, arsenic contamination and continuous cropping constitute hurdles to further increases in the agricultural production of P. notoginseng. This review focuses on the traditional uses (based on traditional Chinese medicine theory), major chemical components, biological activities, pharmacological properties, geographical distributions and historical development of taxonomy of P...
May 14, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29756589/effect-of-combination-therapy-with-neuroprotective-and-vasoprotective-agents-on-cerebral-ischemia
#5
Jiping Yang, Bei Yang, Baoxin Xiu, Jinchong Qi, Huaijun Liu
Because most tested drugs are active against only one of the damaging processes associated with stroke, other mechanisms may cause cellular death. Thus, a combination of protective agents targeting different pathophysiological mechanisms may obtain better effects than a single agent. The major objective of this study was to investigate the effect of combination therapy with vascular endothelial growth factor (VEGF) and nerve growth factor (NGF) after controlled ischemic brain injury in rabbits. METHODS: Animals were randomly assigned to one of the following groups: sham group, saline-treated control group or NGF+VEGF-treated group...
May 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29756588/toward-a-shared-care-model-of-relapsing-remitting-multiple-sclerosis-role-of-the-primary-care-practitioner
#6
Jiwon Oh, Marie-Sarah Gagné-Brosseau, Melanie Guenette, Catherine Larochelle, François Lemieux, Suresh Menon, Sarah A Morrow, Laurence Poliquin-Lasnier, Chantal Roy-Hewitson, Carolina Rush, Anne-Marie Trudelle, Paul S Giacomini
The objective of this study was to develop a shared-care model to enable primary-care physicians to participate more fully in meeting the complex, multidisciplinary healthcare needs of patients with multiple sclerosis (MS). DESIGN: The design consisted of development of consensus recommendations and a shared-care algorithm. PARTICIPANTS: A working group of 11 Canadian neurologists involved in the management of patients with MS were included in this study. MAIN MESSAGE: The clinical management of patients with multiple sclerosis is increasing in complexity as new disease-modifying therapies (DMTs) become available, and ongoing safety monitoring is required...
May 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29753677/multicenter-phase-1-2-application-of-adenovirus-specific-t-cells-in-high-risk-pediatric-patients-after-allogeneic-stem-cell-transplantation
#7
Winnie Ip, Juliana M F Silva, Hubert Gaspar, Arindam Mitra, Shreenal Patel, Kanchan Rao, Robert Chiesa, Persis Amrolia, Kimberly Gilmour, Gul Ahsan, Mary Slatter, Andrew R Gennery, Robert F Wynn, Paul Veys, Waseem Qasim
BACKGROUND: Adenovirus (ADV) reactivation can cause significant morbidity and mortality in children after allogeneic stem cell transplantation. Antiviral drugs can control viremia, but viral clearance requires recovery of cell-mediated immunity. METHOD: This study was an open-label phase 1/2 study to investigate the feasibility of generating donor-derived ADV-specific T cells (Cytovir ADV, Cell Medica) and to assess the safety of pre-emptive administration of ADV-specific T cells in high-risk pediatric patients after allogeneic hematopoietic stem cell transplantation (HSCT) to treat adenoviremia...
May 9, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29751700/-research-progress-of-tibetan-medicine-zha-xun
#8
Ming-Ming Zhao, Rui Gu, Jiu-Yu Fan, Yong Zeng, Yun Cao, Wen-Qian Wang, Shi-Hong Zhong, Peng Mi
Zha-xun is widely used in Tibetan medicine and is also an international traditional medicine. This article would summarize the use status and research progress of Zha-xun by various ethnic groups all over the world, and the results show that it has various synonyms but most of them imply its most characteristic feature-outflow from the rock; Zha-xun resources are distributed in various places of the world, and its bearing spots are closely related to the geological structure; there are sharp arguments on the origins of Zha-xun, mainly including the minerals origin, biological fossils origin, biological origin, etc...
April 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29748095/corneal-topography-with-an-aberrometry-topography-system
#9
Michael Mülhaupt, Sven Dietzko, James Wolffsohn, Stefan Bandlitz
PURPOSE: To investigate the agreement between the central corneal radii and corneal eccentricity measurements generated by the new Wave Analyzer 700 Medica (WAV) compared to the Keratograph 4 (KER) and to test the repeatability of the instruments. METHODS: 20 subjects (10 male, mean age 29.1 years, range 21-50 years) were recruited from the students and staff of the Cologne School of Optometry. Central corneal radii for the flat (rc/fl ) and steep (rc/st ) meridian as well as corneal eccentricity for the nasal (enas ), temporal (etemp ), inferior (einf ) and superior (esup ) directions were measured using WAV and KER by one examiner in a randomized order...
May 7, 2018: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29747756/veratrum-nigrum-inhibits-the-estrogenic-activity-of-salvia-miltiorrhiza-bunge-in-vivo-and-in-vitro
#10
Ying Xu, Ting Chen, Xin Li, Qu Ya Kun, Jin Na An, Hong Xia Zheng, Yuan Zhao, Zi Jia Zhang, Na Lin
BACKGROUND: As recorded in the 18 incompatible medicaments of Traditional Chinese Medicine theory, the combined use of Salvia miltiorrhiza bunge (SM) and Veratrum nigrum (VN) could induce toxicity and has been prohibited for thousands of years in China. However, the theory has been validated due to lack of evidence. Previous studies have focused on the chemical constituents that are responsible for the toxicity of the two agents. PURPOSE: This study offers preliminary insight into the pharmacodynamics and mechanism of estrogenic activity responsible for their incompatibility...
April 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29741926/efficacy-of-a-combination-of-melissa-officinalis-l-and-nepeta-menthoides-boiss-buhse-on-insomnia-a-triple-blind-randomized-placebo-controlled-clinical-trial
#11
Maryam Ranjbar, Alireza Salehi, Hossein Rezaeizadeh, Mohammad M Zarshenas, Khosro Sadeghniiat-Haghighi, Mehran Mirabzadeh, Ali Firoozabadi
BACKGROUND: Insomnia is a prevalent sleep disorder that has not been well managed thus far. There are numerous medicaments for treatment of insomnia, but they have undesirable side effects that make herbal medicine a more viable option. OBJECTIVES: The effectiveness of a combination of Melissa officinalis L. (dry powder) and Nepeta menthoides Boiss. & Buhse (freeze-dried aqueous extract) on insomnia was evaluated. DESIGN AND SETTING: Insomniacs who met the entry criteria participated in a triple-blind randomized placebo-controlled clinical trial at the Persian Medicine (PM) clinic in Tehran...
May 9, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29736825/bleeding-events-attributable-to-concurrent-use-of-warfarin-and-other-medications-in-high-risk-elderly-meta-analysis-and-italian-population-based-investigation
#12
Rosanna Irene Comoretto, Federico Rea, Ersilia Lucenteforte, Alessandro Mugelli, Gianluca Trifirò, Silvia Cascini, Giuseppe Roberto, Alessandro Chinellato, Amelia Filippelli, Giovanni Corrao
PURPOSE: The aim of this study was to estimate the proportion of bleedings that occurred among warfarin users attributable to the concomitant use of other medications. A general approach for measuring the impact of the prescriptive inappropriateness on drug adverse outcomes at the population level is described. METHODS: A meta-analysis was conducted to obtain summary relative risks of bleeding associated with concurrent use of warfarin and other medications compared to warfarin use alone...
May 7, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29735798/thrombosis-of-the-portal-venous-system-in-cirrhotic-vs-non-cirrhotic-patients
#13
Vania Cruz-Ramón, Paulina Chinchilla-López, Oscar Ramírez-Pérez, Nancy E Aguilar-Olivos, Luis F Alva-López, Ericka Fajardo-Ordoñez, Ileana Acevedo-Silva, Patrick G Northup, Nicolas Intagliata, Stephen H Caldwell, Guadalupe Ponciano-Rodríguez, Xingshun Qi, Nahum Méndez-Sánchez
INTRODUCTION AND AIM: Thrombosis is a vascular disorder of the liver often associated with significant morbidity and mortality. Cirrhosis is a predisposing factor for portal venous system thrombosis. The aim of this study is to determine differences between cirrhotics and non-cirrhotics that develop thrombosis in portal venous system and to evaluate if cirrhosis severity is related to the development of portal venous system thrombosis. MATERIAL AND METHODS: We studied patients diagnosed with portal venous system thrombosis using contrast-enhanced computed tomography scan and doppler ultrasound at Medica Sur Hospital from 2012 to 2017...
April 9, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29734660/syzygium-cordatum-hochst-ex-krauss-an-overview-of-its-ethnobotany-phytochemistry-and-pharmacological-properties
#14
REVIEW
Alfred Maroyi
Syzygium cordatum is a valuable medicinal plant in the materia medica of east and southern Africa. The aim of this study was to review the botany, medicinal uses, phytochemistry and ethnopharmacological properties of S. cordatum . Relevant literature search was carried out using internet sources such as ACS, Web of Science, Wiley, SpringerLink, Scopus, Mendeley, Google Scholar, Pubmed, SciFinder, BioMed Central, Science Direct and Elsevier. Other literature sources were conference papers, book chapters, books, theses and websites...
May 4, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29733072/la-importancia-de-la-farmacovigilancia-intrahospitalaria-en-la-detecci%C3%A3-n-oportuna-de-los-errores-de-medicaci%C3%A3-n
#15
Francisco Villegas, David Figueroa-Montero, Varenka Barbero-Becerra, Eva Juárez-Hernández, Misael Uribe, Norberto Chávez-Tapia, Octavio González-Chon
Introducción: Los pacientes hospitalizados son susceptibles a errores de medicación, que representan entre la cuarta y sexta causa de muerte. El servicio de farmacovigilancia intrahospitalaria interviene en todo el proceso de medicación con el fin prevenir, corregir y evaluar los daños. Objetivo: Analizar los errores de medicación reportados por el sistema de farmacovigilancia de la Fundación Clínica Médica Sur, México, y su impacto en los pacientes. Método: Estudio prospectivo efectuado de 2012 a 2015, en el que se registraron las prescripciones de medicamente a los pacientes...
2018: Gaceta Médica de México
https://www.readbyqxmd.com/read/29733069/el-movimiento-m%C3%A3-dico-y-el-doctor-ismael-cos%C3%A3-o-villegas-a-medio-siglo
#16
José Luis Sandoval-Gutiérrez
En 1964, los médicos residentes e internos de la República Mexicana decidieron realizar un paro de labores que se extendió por meses; varios médicos notables decidieron unirse a las causas que motivaron dicho movimiento, entre ellos el director general en ese momento del Sanatorio para Tuberculosos de Huipulco, el doctor Ismael Cosío Villegas, cuya participación y entrega es histórica. La determinación del doctor Cosío Villegas provocó que se le exigiera su renuncia. La comunidad médica aún se desconoce su trayectoria...
2018: Gaceta Médica de México
https://www.readbyqxmd.com/read/29733066/de-las-primeras-iniciativas-de-medicina-laboral-en-m%C3%A3-xico-el-hospital-de-mineros-de-real-del-monte
#17
José Luis Gómez, Carlos Agustín Rodríguez-Paz
A pesar de la legislación de Otto von Bismarck (1815-1898) sobre derechos de seguridad social formulada en 1883 en Alemania donde se señala que es deber del Estado promover el bienestar de todos los miembros de la sociedad, particularmente de los más débiles y necesitados utilizando los medios con los que dispone, y las propuestas de leyes contra accidentes expedidas el 30 de abril de 1904 en el Estado de México, en el México del porfiriato no se consideró brindar atención médica formal a los trabajadores, salvo algunas empresas ferrocarrileras, no se construyeron hospitales para atender a pacientes con enfermedades laborales...
2018: Gaceta Médica de México
https://www.readbyqxmd.com/read/29732332/case-report-of-a-pustular-dermatitis-outbreak-in-sheep-clinical-and-food-safety-considerations
#18
Mariana Roccaro, Silvia Piva, Alessandra Scagliarini, Federica Giacometti, Andrea Serraino, Giuseppe Merialdi, Matteo Frasnelli, Angelo Romano, Alberto Bellio, Lucia Decastelli, Angelo Peli
The objective of this report is to describe an outbreak of pustular dermatitis in a flock of about 200 sheep, its clinical evolution and food safety implications. The onset of the symptoms was sudden and the lesions spread very quickly from ewe to ewe, so that in about 3 days almost all of the lactating sheep were stricken. Pustules from 5 different animals, six milk samples, two cheese samples, teat cup samples from the milking machine and farmer's hands were analysed. A pure culture of Staphylococcus aureus , producing staphylococcal enterotoxin (SE) C, was isolated from pustules...
March 31, 2018: Italian Journal of Food Safety
https://www.readbyqxmd.com/read/29730538/sequential-concentrations-of-placental-growth-factor-and-haptoglobin-and-their-relation-to-oestrone-sulphate-and-progesterone-in-pregnant-spanish-purebred-mare
#19
K Satué, M Marcilla, P Medica, A Ferlazzo, E Fazio
The objectives of this study were to establish reference values for serum concentrations of placental growth factor (PlGF) and haptoglobin (Hp), and to analyze whether the levels of oestrone sulphate (E1 S) and progesterone (P4 ) are physiologically involved in the dynamic modifications of the above parameters in pregnant mares. A total of 30 healthy Spanish Purebred mares ranging in age 9.33 ± 3.31 years were studied during the 11 months of gestation. Serum concentrations of PlGF were detected by EIA, Hp using commercial Phase Haptoglobin assay and E1 S and P4 levels through RIA...
April 27, 2018: Theriogenology
https://www.readbyqxmd.com/read/29728017/-ginseng-prescription-rules-and-molecular-mechanism-in-treating-coronary-heart-disease-based-on-data-mining-and-integrative-pharmacology
#20
Sen Li, Shi-Huan Tang, Jin-Ling Liu, Jin Su, Fu-Yuan He
The ancient dragon Materia Medica, Compendium of Materia Medica and other works recorded that the main effect of ginseng is tonifying qi. It is reported that the main active ingredient of ginseng is ginsenoside. Modern studies have found that ginseng mono saponins are effective for cardiovascular related diseases. This paper preliminary clarified the efficacy of traditional ginseng-nourishing qi and cardiovascular disease through the traditional Chinese medicine (TCM) inheritance auxiliary platform and integration platform of association of pharmacology...
April 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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