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https://www.readbyqxmd.com/read/29155449/baicalein-inhibits-acinar-to-ductal-metaplasia-of-pancreatic-acinal-cell-ar42j-via-improving-the-inflammatory-microenvironment
#1
Wei-Ling Pu, Ying-Ying Luo, Ru-Yu Bai, Ao-Wei Guo, Kun Zhou, Yun-Sha Zhang, Lin Miao, Curzio Rüegg, Micheal O Hottiger, Xiu-Mei Gao, Li-Kang Sun
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers. Recent research has demonstrated that chronic pancreatitis (CP) is associated with an increased risk of PDAC, partly due to acinar-to-ductal metaplasia (ADM). Baicalein has been shown to exert anti-inflammatory and anti-tumor effects for CP or PDAC, respectively. The aim of our study was to investigate the effect of baicalein, and the putative underlying mechanism, on inflammatory cytokines-induced ADM of rat pancreatic acinar cell line AR42J...
November 20, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29149812/architectures-and-mechanical-properties-of-drugs-and-complexes-of-surface-active-compounds-at-air-water-and-oil-water-interfaces
#2
Dipak K Sarker
BACKGROUND: Drugs can represents a multitude of compounds from proteins and peptides, such as growth hormones and insulin and on to simple organic molecules such as flurbiprofen, ibuprofen and lidocaine. Given the chemical nature of these compounds two features are always present. A portion or portions of the molecule that has little affinity for apolar surfaces and media and the opposite a series of part or one large part that has considerable affinity for hydrophilic, polar or charged media and surfaces...
November 17, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29147757/prospective-evaluation-of-co2-laser-assisted-sclerectomy-surgery-class-with-mitomycin-c
#3
Carlo Alberto Cutolo, Alessandro Bagnis, Riccardo Scotto, Chiara Bonzano, Carlo Enrico Traverso
PURPOSE: Our purpose was to evaluate the clinical safety and efficacy of CO2 laser-assisted sclerectomy surgery (CLASS) with Mitomycin C (MMC) in open angle glaucoma (OAG). METHODS: This was a prospective, uncontrolled, interventional case series. All subjects underwent CLASS procedure by a single surgeon. After the dissection of a partial thickness scleral flap, topical MMC 0.2 mg/ml was applied to the sclera and the conjunctiva for 3 min. The CO2 laser with a beam-manipulating system was used to ablate the scleral tissue and expose the Schlemm's canal area...
November 17, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29142877/removal-efficacy-and-cytotoxicity-of-a-calcium-hydroxide-paste-using-n-2-methyl-pyrrolidone-as-a-vehicle
#4
Myung-Jin Lim, Hyun-Jin Jang, Mi-Kyung Yu, Kwang-Won Lee, Kyung-San Min
Objectives: This study investigated the removal efficacy and cytotoxicity of a newly developed calcium hydroxide paste (cleaniCal, Maruchi) using N-2-methyl-pyrrolidone (NMP) as a vehicle in comparison with ApexCal (Ivoclar Vivadent) and Calcipex II (Nishika), which use different vehicles such as polyethylene glycol and propylene glycol, respectively. Materials and Methods: Thirty maxillary premolars with oval-shaped canals were divided into 3 groups and the teeth were filled with one of the pastes...
November 2017: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/29142874/evaluation-of-antimicrobial-activity-and-efficacy-of-herbal-oils-and-extracts-in-disinfection-of-gutta-percha-cones-before-obturation
#5
Chetana S Makade, Pratima R Shenoi, Elakshi Morey, Ameya V Paralikar
Objectives: Literature has shown that micro-organisms contaminate gutta percha (GP) during storage and manipulation. Till date herbal extracts are not explored as an alternative medicament for pre-operative chairside disinfection of GP cones. The purpose of our study was to evaluate the antimicrobial activity and efficacy of lemon grass oil (LG), basil oil (BO), and obicure tea extract (OT) in disinfecting GP cones before obturation. Materials and Methods: Agar diffusion method was used to evaluate the antimicrobial efficacy of LG, BO, OT, and sodium hypochlorite (control) against common contaminants, namely, Enterococcus faecalis, Staphylococcus aureus, and Candida albicans...
November 2017: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/29142426/in-silico-and-in-vitro-anticancer-activity-of-isolated-novel-marker-compound-from-chemically-modified-bioactive-fraction-from-curcuma-longa-nccl
#6
Arshi Naqvi, Richa Malasoni, Swati Gupta, Akansha Srivastava, Rishi R Pandey, Anil Kumar Dwivedi
Background: Turmeric (Curcuma longa) is reported to possess wide array of biological activities. Herbal Medicament (HM) is a standardized hexane-soluble fraction of C. longa and is well known for its neuroprotective effect. Objective: In this study, we attempted to synthesize a novel chemically modified bioactive fraction from HM (NCCL) along with isolation and characterization of a novel marker compound (I). Materials and Methods: NCCL was prepared from HM...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29137336/percutaneous-laser-ablation-for-benign-thyroid-nodules-a-meta-analysis
#7
Wei Fan Sui, Jian Yun Li, Jian Hua Fu
Purpose: To evaluate percutaneous laser ablation in treating benign thyroid nodules, we conducted a meta-analysis based on summarizing existing researches. Materials and Methods: A literature search for clinical trial was performed in PubMed, Cochrane Library and Excerpt Medica Database. The qualities of included studies were evaluated. We calculated the indexes with mean difference. Heterogeneity and publication bias were tested and explored. We performed subgroup analyses and sensitivity analysis further...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29134721/atr-ftir-spectroscopy-and-%C3%AE-edxrf-spectrometry-monitoring-of-enamel-erosion-caused-by-medicaments-used-in-the-treatment-of-respiratory-diseases
#8
Raimundo Nonato Silva Gomes, Tanmoy T Bhattacharjee, Luis Felipe C S Carvalho, Luís Eduardo Silva Soares
Medicaments essential for alleviation of diseases may sometime adversely affect dental health by eroding the enamel, owing to their acidic nature. It is therefore highly desirable to be able to detect these effects quickly and reliably. In this study, we evaluated the erosive capacity of four most commonly prescribed respiratory disease syrup medicaments on enamel using micro-energy-dispersive X-ray fluorescence spectrometry (µ-EDXRF) and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR)...
November 14, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29128423/amorphous-solid-dispersions-and-nanocrystal-technologies-for-poorly-water-soluble-drug-delivery-an-update
#9
Scott V Jermain, Chris Brough, Robert O Williams
Poor water-solubility remains a typical property of drug candidates in pharmaceutical development pipelines today. Various processes have been developed to increase the solubility, dissolution rate, and bioavailability of these active ingredients belonging to biopharmaceutical classification system (BCS) II and IV classifications. Since the early 2000s, nanocrystal delivery and amorphous solid dispersions are more established techniques to overcome the limitations of poorly-water soluble drugs in FDA available products...
November 8, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29126628/effect-of-transportation-on-the-sympatho-adrenal-system-responses-in-horses
#10
Pietro Medica, Giuseppe Bruschetta, Cristina Cravana, Adriana Ferlazzo, Esterina Fazio
The objective of current study was to evaluate the effect of transportation stress on the circulating adrenaline (A), noradrenaline (NA) and dopamine (DA) responses of stallions, according to the different distances. Forty-two stallions were studied before and after road transportation of 100, 200 and 300km, for a period of 1-3h. An increase in plasma A after 100km (P<0.001) was observed. A similar result was seen in plasma NA after 100km (P<0.001), and 300km (P<0.001). Increases in plasma DA after 100 and 200km (P<0...
October 25, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29124712/safety-and-efficacy-of-phototherapy-in-the-management-of-eczema
#11
Annalisa Patrizi, Beatrice Raone, Giulia Maria Ravaioli
Atopic Dermatitis (AD), a common skin disease, can occur in patients of all age, gender and ethnicity. It is an inflammatory affection, characterized by chronic and highly debilitating behavior. First-line interventions against AD include environmental measures and topical emollients, corticosteroids or calcineurin inhibitors. When these measures are not sufficient, phototherapy represents an efficient second-line option of treatment; it can be administered on its own, or in the most severe cases combined with systemic medicaments such as corticosteroids...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29121124/atopic-dermatitis-prevention-and-treatment
#12
Nanette B Silverberg
Atopic dermatitis (AD) is the cause of substantial morbidity including severe pruritus and impaired personal and familial quality of life. Furthermore, the rising incidence and familial association of AD have highlighted the need for disease prevention. It is largely genetic in nature and cannot be avoided in all cases. However, low-risk prevention strategies have been attempted to reduce triggering of first onset of AD in predisposed individuals. Therapeutics for active disease include trigger avoidance, barrier repair, topical medicaments including topical corticosteroids (TCs) and nonsteroidal agents, phototherapy, and antibacterial interventions...
September 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29116303/non-invasive-brain-stimulation-and-computational-models-in-post-stroke-aphasic-patients-single-session-of-transcranial-magnetic-stimulation-and-transcranial-direct-current-stimulation-a-randomized-clinical-trial
#13
Michele Devido Dos Santos, Vitor Breseghello Cavenaghi, Ana Paula Machado Goyano Mac-Kay, Vitor Serafim, Alexandre Venturi, Dennis Quangvinh Truong, Yu Huang, Paulo Sérgio Boggio, Felipe Fregni, Marcel Simis, Marom Bikson, Rubens José Gagliardi
CONTEXT AND OBJECTIVE: Patients undergoing the same neuromodulation protocol may present different responses. Computational models may help in understanding such differences. The aims of this study were, firstly, to compare the performance of aphasic patients in naming tasks before and after one session of transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS) and sham, and analyze the results between these neuromodulation techniques; and secondly, through computational model on the cortex and surrounding tissues, to assess current flow distribution and responses among patients who received tDCS and presented different levels of results from naming tasks...
November 6, 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/29111267/process-optimization-and-in-vivo-performance-of-docetaxel-loaded-phbv-tpgs-therapeutic-vesicles-a-synergistic-approach
#14
Harsh Vardhan, Pooja Mittal, Sandeep Kumar Reddy Adena, Mansi Upadhyay, Sarita Kumari Yadav, Brahmeshwar Mishra
This research was motivated due to substantial requirement of improved treatment for breast cancer which accounts for over 0.52 million deaths annually worldwide. Utilizing nanoparticles carrying active medicaments as targeted delivery carrier is emerging as a promising approach. For a drug to be clinically effective, it needs to be suitably protected in the biological fluid till it is delivered to the targeted site. Keeping above in mind, we prepared and optimized polymeric nanoparticles by polyhydroxybutyrate-co-hydroxyvalerate (PHBV) a biodegradable polymer utilizing modified emulsification solvent evaporation method...
October 27, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29109316/evaluation-and-comparison-between-formocresol-and-sodium-hypochlorite-as-pulpotomy-medicament-a-randomized-study
#15
Shikhar P Chauhan, Mukesh Gupta, Hina Ahmed, Ravish Tongya, Dheeraj Sharma, Bhanu Chugh
INTRODUCTION: Pulpotomy is the most common treatment to preserve vitality of cariously exposed molars. Various pulpotomy medicaments used should be antimicrobial, should help in healing without damaging surrounding tissue, and should not affect eruption of permanent teeth. Thus, this study was conducted to evaluate and compare the clinical and radiographic outcomes of formocresol (FC) and sodium hypochlorite (NaOCl) in primary molars. The aim of this randomized study was to compare the clinical and radiographic success rate of FC and 5% NaOCl as a pulpotomy medicament in primary molars...
November 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29104387/evaluation-of-antimicrobial-efficacy-of-various-intracanal-medicaments-in-primary-teeth-an-in-vivo-study
#16
Brahmananda Dutta, Kanika S Dhull, Debasmita Das, P V Samir, Rajnish K Verma, Nipa Singh
Introduction: Bacteria and their products play a primary etiological role in the initiation and perpetuation of pulpoperiapical pathosis. Intracanal medication is important for endodontic success as it eliminates microorganisms that persist after chemomechanical preparation. Aim: To compare antimicrobial efficacy of calcium hydroxide powder, triple antibiotic paste, calcium hydroxide with 2% chlorhexidine solution, and triple antibiotic paste with 2% chlorhexidine solution...
July 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29104382/clinical-and-radiographic-evaluation-of-four-different-pulpotomy-agents-in-primary-molars-a-longitudinal-study
#17
B Sunitha, Ravindar Puppala, Balaji Kethineni, Manoj K Mallela, Ravigna Peddi, P Tarasingh
Background: The medicament formocresol (FC) used for pulpotomy in primary teeth has great concerns regarding its toxicity due to one of its constituent formaldehyde which acts by tissue fixation. Therefore, new medicaments were introduced which claimed preservation and regeneration of pulp. Aim: The present study is aimed to compare and evaluate the clinical and radiographic success of FC, pulpotec, mineral trioxide aggregate (MTA), and emdogain (EMD) as pulpotomy medicaments in human primary molars...
July 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29099365/removal-of-calcium-hydroxide-intracanal-medicament-by-different-irrigants-and-irrigating-techniques-a-cone-beam-computed-tomography-analysis
#18
Prasanna Neelakantan, Priyanka Sriraman, James L Gutmann
The aim of this study was to use cone beam computed tomography (CBCT) to evaluate the removal of calcium hydroxide (Ca[OH]2) from root canals after using different irrigation and activation protocols. Root canals (n = 128) were filled with Ca(OH)2 and scanned using CBCT. The Ca(OH)2 was removed after 1 week using 1 of 12 groups (G1-G12) according to the final irrigating solution: G1, 6% sodium hypochlorite (NaOCl) + 18% etidronic acid (EA) with no activation; G2, NaOCL + EA + passive ultrasonic irrigation (PUI); G3, NaOCl + EA + Finishing File (FF); G4, NaOCl + EA + NaviTip FX irrigation needle (NTFX); G5, 3% NaOCl + 17% ethylenediaminetetraacetic acid (EDTA) with no activation; G6, NaOCl + EDTA + PUI; G7, NaOCl + EDTA + FF; G8, NaOCl + EDTA + NTFX; G9, 3% NaOCl with no activation; G10, NaOCl + PUI; G11, NaOCl + FF; G12, NaOCL + NTFX...
November 2017: General Dentistry
https://www.readbyqxmd.com/read/29098815/-cultural-regionalization-for-notopterygium-incisum-based-on-3s-technology-platform-%C3%A2-functional-regionalization-for-cultivation-based-on-suitability-evaluation-of-growth-and-production-quality
#19
Hong-Bing Sun, Shun-Yuan Jiang, Hui Sun, Hong-Lan Wang, Yi Zhou, Wen-Tao Zhu
Based on the research results of suitability evaluation of growth and production quality, a functional production cultivation regionalization with high feasibility and operability to solve the problem of the separation of high quality and high yield were formatted for protection, wild monitoring, and cultivation of this plant by weighted sum of spatial suitability data of ecology and quality, as well as integrated with land use and cover data. The results of the study revealed that good quality and high yield area were mainly distributed in the original production areas in Sichuan province and where could carry out monitoring and commercialization cultivation...
July 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29090556/-docking-based-virtual-screening-of-mek1-inhibitors-from-chinese-herbs
#20
Yong-Liang Li, Zhi-Yun Du, Jie Zheng
The hyperphosphorylation of MEK1(mitogen-activated protein kinase kinase 1) is one of the causesfor melanoma. It is important to discover a potential medicine for melanoma through virtual screening of chemical composition of Chinese material medica on MEK1. In this study, a docking pocket model and Flex Search model were built by using a MEK1 crystal structure, the similarity between connector conformation and gametophyte conformation in the crystal structure was 0.784.There was a linear relationship between total score and pIC₅₀on MEK1 inhibitors, with R²=0...
May 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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