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https://www.readbyqxmd.com/read/29792760/seroprevalence-of-equine-herpesviruses-1-and-9-ehv-1-and-ehv-9-in-wild-gr%C3%A3-vy-s-zebra-equus-grevyi-in-kenya
#1
Louise Guevara, Azza Abdelgawad, Cynthia Onzere, Alex D Greenwood, Zeke Davidson, Richard Bishop, Mathew Mutinda
Equid herpesviruses types 1 (EHV-1) and 9 (EHV-9) are unusual among herpesviruses in that they lack strong host specificity, and the full extent of their host range remains unclear. The virus establishes latency for long periods and can be reactivated and shed, resulting in clinical disease in susceptible species. A sensitive and specific peptide-based enzyme-linked immunosorbent assay was developed to study the seroprevalence of both viruses in a broad range of species among both wild and captive populations...
May 24, 2018: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29788354/antiviral-effect-of-the-nucleoside-analogue-cidofovir-in-the-context-of-sexual-transmission-of-a-gammaherpesvirus-in-mice
#2
Caroline Zeippen, Justine Javaux, Robert Snoeck, Johan Neyts, Laurent Gillet
Objectives: To investigate the efficacy of cidofovir to block gammaherpesvirus replication in the context of sexual transmission. Methods: A luciferase-expressing strain of murid herpesvirus 4 (MuHV-4) was used to monitor genital virus excretion from infected female BALB/c mice and sexual transmission to naive males. The efficiency of cidofovir to block genital excretion from infected females or replication and host colonization of naive males after sexual contact was tested by treating infected females (either once daily or at a single timepoint), naive males before exposure (either once daily or at a single timepoint) or males 24 h post-exposure...
May 16, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29787887/human-pegivirus-persistence-in-the-human-blood-virome-after-allogeneic-haematopoietic-stem-cell-transplantation
#3
Diem-Lan Vu, Samuel Cordey, Federico Simonetta, Francisco Brito, Mylène Docquier, Lara Turin, Christian van Delden, Elsa Boely, Carole Dantin, Amandine Pradier, Eddy Roosnek, Yves Chalandon, Evgeny M Zdobnov, Stavroula Masouridi-Levrat, Laurent Kaiser
OBJECTIVES: As commensal viruses are defined by the immunological tolerance afforded to them, any immunomodulation, such as is received during haematopoietic stem cell transplantation, may shift the demarcation between innocuous viral resident and disease-causing pathogen. METHODS: We analysed by deep-sequencing the plasma virome of 40 allogeneic haematopoietic stem cell transplant (allo-HSCT) patients 1 month post-transplantation. As human pegivirus (HPgV) was highly prevalent, we performed a one-year screening of 122 plasma samples by specific rRT-PCR assay...
May 19, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29785130/human-herpesvirus-6-pneumonitis-in-a-patient-with-follicular-lymphoma-following-immunochemotherapy-with-rituximab
#4
Saeko Kuwahara-Ota, Yoshiaki Chinen, Yoshimi Mizuno, Tomoko Takimoto-Shimomura, Yayoi Matsumura-Kimoto, Kazuna Tanba, Taku Tsukamoto, Shinsuke Mizutani, Yuji Shimura, Tsutomu Kobayashi, Shigeo Horiike, Junya Kuroda
Primary infection with human herpesvirus-6 (HHV-6) commonly occurs at an early age in children, most often at 3 years of age, and is associated with childhood diseases, such as exanthema subitum, hepatitis, febrile convulsions, or encephalitis. However, the virus occasionally reactivates from its latent state in immunosuppressed adults, especially post-transplant, resulting in serious disseminated, sometimes life-threatening end-organ complications. Herein, we report a case of a 68-year-old man with relapsed follicular lymphoma who developed HHV-6 pneumonitis...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29779790/a-hyperthermophilic-phage-decoration-protein-suggests-common-evolutionary-origin-with-herpesvirus-triplex-proteins-and-an-anti-crispr-protein
#5
Nicholas P Stone, Brendan J Hilbert, Daniel Hidalgo, Kevin T Halloran, Jooyoung Lee, Erik J Sontheimer, Brian A Kelch
Virus capsids are protein shells that protect the viral genome from environmental assaults, while maintaining the high internal pressure of the tightly packaged genome. To elucidate how capsids maintain stability under harsh conditions, we investigated the capsid components of the hyperthermophilic phage P74-26. We determined the structure of capsid protein gp87 and show that it has the same fold as decoration proteins in many other phages, despite lacking significant sequence homology. We also find that gp87 is significantly more stable than mesophilic homologs...
April 26, 2018: Structure
https://www.readbyqxmd.com/read/29774842/detection-of-low-pathogenicity-influenza-a-h7n3-virus-during-duck-mortality-event-cambodia-2017
#6
Annika Suttie, Sokhoun Yann, Phalla Y, Sothyra Tum, Yi-Mo Deng, Vibol Hul, Viseth Srey Horm, Ian Barr, Andrew Greenhill, Paul F Horwood, Kristina Osbjer, Erik A Karlsson, Philippe Dussart
In January 2017, an estimated 3,700 (93%) of 4,000 Khaki Campbell ducks (Anas platyrhynchos domesticus) died in Kampong Thom Province, Cambodia. We detected low pathogenicity avian influenza A(H7N3) virus and anatid herpesvirus 1 (duck plague) in the affected flock; however, the exact cause of the mortality event remains unclear.
June 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29773792/mxb-is-an-interferon-induced-restriction-factor-of-human-herpesviruses
#7
Michel Crameri, Michael Bauer, Nicole Caduff, Raphael Walker, Fiona Steiner, Francesca D Franzoso, Cornelia Gujer, Karin Boucke, Talissa Kucera, Andrea Zbinden, Christian Münz, Cornel Fraefel, Urs F Greber, Jovan Pavlovic
The type I interferon (IFN) system plays an important role in controlling herpesvirus infections, but it is unclear which IFN-mediated effectors interfere with herpesvirus replication. Here we report that human myxovirus resistance protein B (MxB, also designated Mx2) is a potent human herpesvirus restriction factor in the context of IFN. We demonstrate that ectopic MxB expression restricts a range of herpesviruses from the Alphaherpesvirinae and Gammaherpesvirinae, including herpes simplex virus 1 and 2 (HSV-1 and HSV-2), and Kaposi's sarcoma-associated herpesvirus (KSHV)...
May 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29769345/the-major-tegument-protein-of-bovine-herpesvirus-1-vp8-interacts-with-dna-damage-response-proteins-and-induces-apoptosis
#8
Sharmin Afroz, Ravendra Garg, Michel Fodje, Sylvia van Drunen Littel-van den Hurk
VP8, the UL47 gene product in bovine herpes virus-1 (BoHV-1), is a major tegument protein, essential for virus replication in vivo The major DNA damage response protein, ataxia telangiectasia mutated (ATM), phosphorylates Nijmegen breakage syndrome (NBS1) and structural maintenance of chromosome-1 (SMC1) proteins during the DNA damage response. VP8 was found to interact with ATM and NBS1 during transfection and BoHV-1 infection. However, VP8 did not interfere with phosphorylation of ATM in transfected or BoHV-1-infected cells...
May 16, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29769344/efficient-delivery-of-hcmv-t-cell-antigens-by-attenuated-sendai-virus-vectors
#9
Richard Kiener, Markus Fleischmann, Marian Alexander Wiegand, Niels A W Lemmermann, Christiane Schwegler, Christine Kaufmann, Angelique Renzaho, Simone Thomas, Eva Felder, Hans Helmut Niller, Benedikt Asbach, Ralf Wagner
Human Cytomegalovirus (HCMV) represents a major cause of clinical complications during pregnancy as well as immunosuppression and the licensing of a protective HCMV vaccine remains an unmet global need. Herein, we designed and validated novel Sendai virus (SeV) vectors delivering T cell immunogens IE-1 and pp65. To enhance vector safety, we used a replication-deficient strain (rdSeV) that infects target cells in a non-productive manner while retaining viral gene expression. In this study, we explored the impact that transduction with rdSeV has on human dendritic cells (DCs) by comparing it to the parental, replication-competent Sendai virus strain (rcSeV) as well as the poxvirus strain Modified Vaccinia Ankara (MVA)...
May 16, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29768502/interferon-lambda-is-required-for-interferon-gamma-expressing-nk-cell-responses-but-does-not-afford-antiviral-protection-during-acute-and-persistent-murine-cytomegalovirus-infection
#10
Silvia Gimeno Brias, Morgan Marsden, Jessica Forbester, Mathew Clement, Cordelia Brandt, Katherine Harcourt, Leanne Kane, Lucy Chapman, Simon Clare, Ian R Humphreys
Interferon lambda (IFNλ) is a group of cytokines that belong to the IL-10 family. They exhibit antiviral activities against certain viruses during infection of the liver and mucosal tissues. Here we report that IFNλ restricts in vitro replication of the β-herpesvirus murine cytomegalovirus (mCMV). However, IFNλR1-deficient (Ifnλr1-/-) mice were not preferentially susceptible to mCMV infection in vivo during acute infection after systemic or mucosal challenge, or during virus persistence in the mucosa. Instead, our studies revealed that IFNλ influences NK cell responses during mCMV infection...
2018: PloS One
https://www.readbyqxmd.com/read/29767614/differential-attenuation-of-marek-s-disease-virus-induced-tumours-and-late-marek-s-disease-virus-induced-immunosuppression
#11
Nik M Faiz, Aneg L Cortes, James S Guy, Sanjay M Reddy, Isabel M Gimeno
Marek's disease virus (MDV) is a herpesvirus that induces lymphoma and a variety of non-neoplastic syndromes in chickens. Furthermore, very virulent plus (vv+) MDVs induce a form of immunosuppression (late-MDV-IS) that might involve both neoplastic and non-neoplastic mechanisms. The objective of this study was to evaluate whether the attenuation of MDV-induced tumours and late-MDV-IS occurs simultaneously or can be dissociated. The immunosuppressive ability of three viruses derived from vv+ MDV strain 686 (wild-type 686, the somewhat attenuated molecular clone 686-BAC, and the nononcogenic molecular clone lacking the two copies of the oncogene meq 686-BACΔMEQ) was evaluated...
May 16, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29762709/determinants-of-%C3%AE-herpesvirus-shedding-in-saliva-among-ugandan-children-and-their-mothers
#12
Robert Newton, Nazzarena Labo, Katie Wakeham, Vickie Marshall, Romin Roshan, Angela Nalwoga, Ismail Sebina, Lawrence Muhangi, Emily L Webb, Wendell Miley, Rosemary Rochford, Alison M Elliott, Denise Whitby
Introduction: Epstein Barr Virus (EBV) and Kaposi's sarcoma associated herpesvirus (KSHV) are transmitted via saliva but factors associated with salivary shedding are unknown. Methods: We measured the shedding of both viruses in the saliva of ~500 Ugandan mothers and their six-year old children, testing all participants for EBV and KSHV seropositive individuals for KSHV. Results: EBV and KSHV were shed by 72% and 22% of the mothers, and by 85% and 40% of children, respectively; boys were more likely than girls to shed KSHV (48% versus 30%), but not EBV...
May 12, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29761571/frequency-of-shedding-of-respiratory-pathogens-in-horses-recently-imported-to-the-united-states
#13
Fauna Leah Smith, Johanna L Watson, Sharon J Spier, Isabelle Kilcoyne, Samantha Mapes, Claudia Sonder, Nicola Pusterla
BACKGROUND: Imported horses that have undergone recent long distance transport might represent a serious risk for spreading infectious respiratory pathogens into populations of horses. OBJECTIVE: To investigate the frequency of shedding of respiratory pathogens in recently imported horses. ANIMALS: All imported horses with signed owner consent (n = 167) entering a USDA quarantine for contagious equine metritis from October 2014 to June 2016 were enrolled in the study...
May 15, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29760169/dysbiosis-of-maternal-and-neonatal-microbiota-associated-with-gestational-diabetes-mellitus
#14
Jinfeng Wang, Jiayong Zheng, Wenyu Shi, Nan Du, Xiaomin Xu, Yanming Zhang, Peifeng Ji, Fengyi Zhang, Zhen Jia, Yeping Wang, Zhi Zheng, Hongping Zhang, Fangqing Zhao
OBJECTIVE: The initial colonisation of the human microbiota and the impact of maternal health on neonatal microbiota at birth remain largely unknown. The aim of our study is to investigate the possible dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus (GDM) and to estimate the potential risks of the microbial shift to neonates. DESIGN: Pregnant women and neonates suffering from GDM were enrolled and 581 maternal (oral, intestinal and vaginal) and 248 neonatal (oral, pharyngeal, meconium and amniotic fluid) samples were collected...
May 14, 2018: Gut
https://www.readbyqxmd.com/read/29755712/lymphoproliferative-syndromes-associated-with-human-herpesvirus-6a-and-human-herpesvirus-6b
#15
REVIEW
Eva Eliassen, Gerhard Krueger, Mario Luppi, Dharam Ablashi
Human herpesvirus 6A and 6B (HHV-6A and HHV-6B) have been noted since their discovery for their T-lymphotropism. Although it has proven difficult to determine the extent to which HHV-6A and HHV-6B are involved in the pathogenesis of many diseases, evidence suggests that primary infection and reactivation of both viruses may induce or contribute to the progression of several lymphoproliferative disorders, ranging from benign to malignant and including infectious mononucleosis-like illness, drug induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS), and nodular sclerosis Hodgkin's lymphoma...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29748909/the-effect-of-storage-temperature-on-the-biological-activity-of-extracellular-vesicles-for-the-complement-system
#16
Sang June Park, Hyungtaek Jeon, Seung-Min Yoo, Myung-Shin Lee
Extracellular vesicles (EVs) are mediators of intercellular communication by transporting cargo containing proteins, lipids, mRNA, and miRNA. There is increasing evidence that EVs have various roles in regulating migration, invasion, stemness, survival, and immune functions. Previously, we have found that EVs from Kaposi's sarcoma-associated herpesvirus (KSHV)-infected human endothelial cells have the potential to activate the complement system. Although many studies have shown that the physical properties of EVs can be changed by their storage condition, there have been few studies for the stability of biological activity of EVs in various storage conditions...
May 10, 2018: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/29748409/genome-sequence-of-a-novel-alloherpesvirus-isolated-from-glass-catfish-kryptopterus-bicirrhis
#17
Rachel N Henriquez, Jaree Polchana, Somkiat Kanchanakhan, Andrew J Davison, Thomas B Waltzek, Kuttichantran Subramaniam
The 149,343-bp genome of silurid herpesvirus 1, which was isolated in Thailand from glass catfish, was sequenced. The genome was most closely related to that of ictalurid herpesvirus 2, which infects black bullhead catfish. To our knowledge, this was the first silurid catfish alloherpesvirus genome to be sequenced.
May 10, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29746593/peroxisomes-support-human-herpesvirus-8-latency-by-stabilizing-the-viral-oncogenic-protein-vflip-via-the-mavs-traf-complex
#18
Young Bong Choi, Yeeun Choi, Edward William Harhaj
Human herpesvirus 8 (HHV-8) is causally related to human malignancies. HHV-8 latent viral FLICE-inhibitory protein (vFLIP) is a viral oncoprotein that is linked to pathogenesis, but how its expression is regulated is largely unknown. In an attempt to understand the role of the mitochondrial antiviral signaling (MAVS) adaptor in HHV-8 infection, we discovered that vFLIP expression was post-translationally up-regulated by the MAVS signaling complex on peroxisomes. Furthermore, we demonstrated that vFLIP could be targeted to the peroxisomes, where it was oncogenically active, in a PEX19-dependent manner...
May 10, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29746587/metabolic-reprogramming-of-kaposi-s-sarcoma-associated-herpes-virus-infected-b-cells-in-hypoxia
#19
Rajnish Kumar Singh, Fengchao Lang, Yonggang Pei, Hem Chandra Jha, Erle S Robertson
Kaposi's sarcoma associated herpesvirus (KSHV) infection stabilizes hypoxia inducible factors (HIFs). The interaction between KSHV encoded factors and HIFs plays a critical role in KSHV latency, reactivation and associated disease phenotypes. Besides modulation of large-scale signaling, KSHV infection also reprograms the metabolic activity of infected cells. However, the mechanism and cellular pathways modulated during these changes are poorly understood. We performed comparative RNA sequencing analysis on cells with stabilized hypoxia inducible factor 1 alpha (HIF1α) of KSHV negative or positive background to identify changes in global and metabolic gene expression...
May 10, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29746560/clinical-virological-and-epidemiological-characterization-of-an-outbreak-of-testudinid-herpesvirus-3-in-a-chelonian-captive-breeding-facility-lessons-learned-and-first-evidence-of-tehv3-vertical-transmission
#20
Maria Luisa Marenzoni, Lorenzo Santoni, Andrea Felici, Carmen Maresca, Valentina Stefanetti, Monica Sforna, Maria Pia Franciosini, Patrizia Casagrande Proietti, Francesco Carlo Origgi
Testudinid herpesviruses (TeHVs) have a worldwide distribution among tortoises. However, information such as risk factors promoting the occurrence or the recrudescence of the associated disease and the mid-term sequelae of an outbreak comprising the extent and dynamic of the viral shedding have been only minimally investigated. Critical management information is also lacking or anecdotal. Furthermore, major aspects of the viral pathogenesis including the likelihood of vertical transmission of the virus are virtually unknown...
2018: PloS One
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