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https://www.readbyqxmd.com/read/28511883/a-prostate-cancer-nimbosus-genomic-instability-and-schlap1-dysregulation-underpin-aggression-of-intraductal-and-cribriform-subpathologies
#1
Melvin L K Chua, Winnie Lo, Melania Pintilie, Jure Murgic, Emilie Lalonde, Vinayak Bhandari, Osman Mahamud, Anuradha Gopalan, Charlotte F Kweldam, Geert J L H van Leenders, Esther I Verhoef, Agnes Marije Hoogland, Julie Livingstone, Alejandro Berlin, Alan Dal Pra, Alice Meng, Junyan Zhang, Michèle Orain, Valérie Picard, Hélène Hovington, Alain Bergeron, Louis Lacombe, Yves Fradet, Bernard Têtu, Victor E Reuter, Neil Fleshner, Michael Fraser, Paul C Boutros, Theodorus H van der Kwast, Robert G Bristow
BACKGROUND: Intraductal carcinoma (IDC) and cribriform architecture (CA) represent unfavorable subpathologies in localized prostate cancer. We recently showed that IDC shares a clonal ancestry with the adjacent glandular adenocarcinoma. OBJECTIVE: We investigated for the co-occurrence of "aggression" factors, genomic instability and hypoxia, and performed gene expression profiling of these tumors. DESIGN, SETTING, AND PARTICIPANTS: A total of 1325 men were treated for localized prostate cancer from four academic institutions (University Health Network, CHU de Québec-Université Laval, Memorial Sloan Kettering Cancer Center [MSKCC], and Erasmus Medical Center)...
May 13, 2017: European Urology
https://www.readbyqxmd.com/read/28505173/continental-divide-predicting-climate-mediated-fragmentation-and-biodiversity-loss-in-the-boreal-forest
#2
Dennis L Murray, Michael J L Peers, Yasmine N Majchrzak, Morgan Wehtje, Catarina Ferreira, Rob S A Pickles, Jeffrey R Row, Daniel H Thornton
Climate change threatens natural landscapes through shifting distribution and abundance of species and attendant change in the structure and function of ecosystems. However, it remains unclear how climate-mediated variation in species' environmental niche space may lead to large-scale fragmentation of species distributions, altered meta-population dynamics and gene flow, and disrupted ecosystem integrity. Such change may be especially relevant when species distributions are restricted either spatially or to a narrow environmental niche, or when environments are rapidly changing...
2017: PloS One
https://www.readbyqxmd.com/read/28503870/correcting-hazard-ratio-estimates-for-outcome-misclassification-using-multiple-imputation-with-internal-validation-data
#3
Jiayi Ni, Aaron Leong, Kaberi Dasgupta, Elham Rahme
OBJECTIVE: Outcome misclassification may occur in observational studies using administrative databases. We evaluated a two-step multiple imputation approach based on complementary internal validation data obtained from two subsamples of study participants to reduce bias in hazard ratio (HR) estimates in Cox regressions. METHODS: We illustrated this approach using data from a surveyed sample of 6247 individuals in a study of statin-diabetes association in Quebec...
May 15, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28501814/a-scoping-review-protocol-on-social-participation-of-indigenous-elders-intergenerational-solidarity-and-their-influence-on-individual-and-community-wellness
#4
Chantal Viscogliosi, Hugo Asselin, Suzy Basile, Yves Couturier, Marie-Josée Drolet, Dominique Gagnon, Jill Torrie, Mélanie Levasseur
INTRODUCTION: Indigenous elders have traditionally played an important role in maintaining social cohesion within their communities. Today, part of this role has been taken over by government social and healthcare services, but they are having limited success in addressing social challenges. Increasing elders' social participation and intergenerational solidarity might foster community development and benefit young people, families, communities and the elders themselves. However, knowledge of the contribution of elders' social participation and intergenerational solidarity to wellness is scattered and needs to be synthesised...
May 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/28487349/patient-centred-innovations-for-persons-with-multimorbidity-funded-evaluation-protocol
#5
Moira Stewart, Martin Fortin
BACKGROUND: The high prevalence of multimorbidity necessitates rethinking of the health care system. The overarching goal of the Patient-Centred Innovations for Persons with Multimorbidity program is to build on existing structures and find and evaluate patient-centred innovations relevant to multimorbidity. METHODS: We describe the protocol for a proposed multijurisdictional (Quebec and Ontario) concurrent triangulation mixed-methods study. In both provinces, a qualitative descriptive study will be used to explore innovations in patient-centred multimorbidity care...
May 9, 2017: CMAJ Open
https://www.readbyqxmd.com/read/28483785/association-between-interpersonal-continuity-of-care-and-medication-adherence-in-type-2-diabetes-an-observational-cohort-study
#6
Anara Richi Dossa, Jocelyne Moisan, Line Guénette, Sophie Lauzier, Jean-Pierre Grégoire
BACKGROUND: Prior studies have shown that, compared to patients with a low level of interpersonal continuity of care, patients with a high level of continuity of care have a lower likelihood of hospital admission and emergency department visits, and a higher likelihood of patient satisfaction. We sought to determine whether higher levels of continuity of care are associated with medication persistence and compliance among new users of oral antidiabetic treatment. METHODS: We conducted a medicoadministrative cohort study of new users of oral antidiabetics aged 18 years or more among people covered by the Quebec public drug plan...
May 8, 2017: CMAJ Open
https://www.readbyqxmd.com/read/28479964/relationship-between-academic-performance-with-physical-psychosocial-lifestyle-and-sociodemographic-factors-in-female-undergraduate-students
#7
Marie-Maude Dubuc, Mylène Aubertin-Leheudre, Antony D Karelis
BACKGROUND: The purpose of this study was to investigate the relationship between physical, psychosocial, lifestyle and sociodemographic factors with academic performance in female undergraduate students. METHODS: One hundred undergraduate female students from the Faculty of Science at the University of Quebec at Montreal participated in this study (mean age = 24.4 ± 4.6 years old). All participants provided their university transcript and had to complete at least 45 course credits from their bachelor degree...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28472373/association-between-bacillus-calmette-gu%C3%A3-rin-bcg-vaccination-and-childhood-asthma-in-the-qu%C3%A3-bec-birth-cohort-on-immunity-and-health
#8
Mariam El-Zein, Florence Conus, Andrea Benedetti, Dick Menzies, Marie-Elise Parent, Marie-Claude Rousseau
We estimated the association between Bacillus-Calmette Guérin (BCG) vaccination and childhood asthma in a birth cohort using administrative databases, and determined the impact of adjusting for potential confounders collected from a subset of subjects. Multiple data sources were used: 1) administrative data for 76,623 subjects (stage 1) in the Québec Birth Cohort on Immunity and Health (1974-1994) including BCG vaccination, perinatal and sociodemographic characteristics, and use of health services for asthma; and 2) self-reported asthma risk factors collected in 2012 by telephone interviews with 1,643 subjects (stage 2) using a balanced two-stage sampling design...
May 4, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28472323/hiv-1-strains-belonging-to-large-phylogenetic-clusters-show-accelerated-escape-from-integrase-inhibitors-in-cell-culture-compared-with-viral-isolates-from-singleton-small-clusters
#9
Bluma G Brenner, Ruxandra-Ilinca Ibanescu, Maureen Oliveira, Michel Roger, Isabelle Hardy, Jean-Pierre Routy, Fred Kyeyune, Miguel E Quiñones-Mateu, Mark A Wainberg
Objectives: Viral phylogenetics revealed two patterns of HIV-1 spread among MSM in Quebec. While most HIV-1 strains ( n  =   2011) were associated with singleton/small clusters (cluster size 1-4), 30 viral lineages formed large networks (cluster size 20-140), contributing to 42% of diagnoses between 2011 and 2015. Herein, tissue culture selections ascertained if large cluster lineages possessed higher replicative fitness than singleton/small cluster isolates, allowing for viral escape from integrase inhibitors...
May 2, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28467103/pathways-linking-childhood-maltreatment-and-adolescent-sexual-risk-behaviors-the-role-of-attachment-security
#10
Marie-Eve Thibodeau, Francine Lavoie, Martine Hébert, Martin Blais
Previous research has shown an association between child maltreatment (sexual abuse, physical abuse, neglect, or witnessing interparental violence) and adolescent sexual risk behaviors (SRBs). The mechanisms explaining this association are not well understood, but attachment theory could provide further insight into them. This study examined the relationships between child maltreatment and SRBs and investigated anxious and avoidant attachment as mediators. The sample comprised 1,900 sexually active adolescents (13 to 17 years old; 60...
May 3, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/28462727/a-prospective-evaluation-of-the-depression-nutrient-intake-reverse-causality-hypothesis-in-a-cohort-of-community-dwelling-older-canadians
#11
Laura Gougeon, Hélène Payette, José A Morais, Pierrette Gaudreau, Bryna Shatenstein, Katherine Gray-Donald
Studies have investigated the potential protective effects that diet may have on late-life depression incidence. This disorder can, however, affect the person's food intake, widely known as the reverse causality hypothesis of depression. To test this hypothesis, we compared mean nutrient intakes from three 24-h recalls during the year depression was detected (Geriatric Depression Scale ≥11 or antidepressant medication) with intakes from 1 year earlier among community-dwelling older adults (67-83 years) followed up annually in the 4-year Québec Longitudinal Study on Nutrition and Aging, who were free of depression and cognitive impairment at baseline...
May 2, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28461374/use-of-antibiotics-during-pregnancy-and-risk-of-spontaneous-abortion
#12
Flory T Muanda, Odile Sheehy, Anick Bérard
BACKGROUND: Although antibiotics are widely used during pregnancy, evidence regarding their fetal safety remains limited. Our aim was to quantify the association between antibiotic exposure during pregnancy and risk of spontaneous abortion. METHODS: We conducted a nested case-control study within the Quebec Pregnancy Cohort (1998-2009). We excluded planned abortions and pregnancies exposed to fetotoxic drugs. Spontaneous abortion was defined as having a diagnosis or procedure related to spontaneous abortion before the 20th week of pregnancy...
May 1, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28460726/-input-data-collection
#13
Julie Duval
The quality and safety of nursing care depends notably on the collection of data. In Quebec, there is a tool which aims to improve the organisation of care in accident and emergency departments. Nurses are on the frontline in the initial assessment of the patient. Unfortunately, their recognition is not on a par with their responsibility.
May 2017: Revue de L'infirmière
https://www.readbyqxmd.com/read/28446419/the-smartphone-peer-physical-activity-counseling-sppac-program-for-manual-wheelchair-users-protocol-of-a-pilot-randomized-controlled-trial
#14
Krista L Best, François Routhier, Shane N Sweet, Kelly P Arbour-Nicitopoulos, Jaimie F Borisoff, Luc Noreau, Kathleen A Martin Ginis
BACKGROUND: Physical activity (PA) must be performed regularly to accrue health benefits. However, the majority of manual wheelchair users do not meet PA recommendations. Existing community-based PA programs for manual wheelchair users appear to work, but effect sizes are small and retention is low. Existing PA programs may not fully implement some psychosocial factors that are strongly linked with PA (eg, autonomy). The use of peers and mobile phone technology in the Smartphone Peer PA Counseling (SPPAC) program represents a novel approach to cultivating a PA-supportive environment for manual wheelchair users...
April 26, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28444846/forensic-analysis-of-latent-fingermarks-by-silver-assisted-ldi-imaging-ms-on-non-conductive-surfaces
#15
Nidia Lauzon, Martin Dufresne, Alexandre Beaudoin, Pierre Chaurand
Silver-assisted laser desorption ionization (AgLDI) imaging mass spectrometry (IMS) has been demonstrated to be a useful technology for fingermark analysis allowing for the detection of several classes of endogenous as well as exogenous compounds. Ideally, in IMS analyses, the fingermarks are deposited under controlled conditions on metallized conductive target slides. However, in forensic investigations, fingermarks are often found on a variety of non-conductive surfaces. A sputtered silver layer renders the target surface conductive, which allows the analyses of insulating surfaces by time-of-flight (TOF) IMS...
April 26, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28443266/cost-effectiveness-of-palivizumab-compared-to-no-prophylaxis-in-term-infants-residing-in-the-canadian-arctic
#16
Anna Banerji, Kaspar Ng, Theo J Moraes, Vladimir Panzov, Joan Robinson, Bonita E Lee
BACKGROUND: Hospital admissions for respiratory syncytial virus infection result in large health expenditures for Inuit infants. Palivizumab has been shown to be highly effective in reducing such admissions in preterm Inuit infants. We performed a cost-effectiveness analysis estimating the incremental cost-effectiveness ratio (ICER) for palivizumab prophylaxis per admission related to respiratory syncytial virus avoided in healthy term infants across the Canadian Arctic. METHODS: We compared universal palivizumab prophylaxis in term infants less than 6 months of age to no prophylaxis in 8 Arctic regions: the Northwest Territories, Nunavut, Nunavut without Iqaluit, the 3 subregions of Nunavut (Kitikmeot, Kivalliq and Qikiqtaaluk), the Qikiqtaaluk Region without Iqaluit, and Nunavik (northern Quebec)...
October 2016: CMAJ Open
https://www.readbyqxmd.com/read/28438951/team-based-versus-traditional-primary-care-models-and-short-term-outcomes-after-hospital-discharge
#17
Bruno D Riverin, Patricia Li, Ashley I Naimi, Erin Strumpf
BACKGROUND: Strategies to reduce hospital readmission have been studied mainly at the local level. We assessed associations between population-wide policies supporting team-based primary care delivery models and short-term outcomes after hospital discharge. METHODS: We extracted claims data on hospital admissions for any cause from 2002 to 2009 in the province of Quebec. We included older or chronically ill patients enrolled in team-based or traditional primary care practices...
April 24, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28427300/object-decision-test-borb-normative-data-for-the-adult-quebec-population-and-performance-in-alzheimer-s-disease-and-the-semantic-variant-of-primary-progressive-aphasia
#18
Alexandre St-Hilaire, Marie-Claude Blackburn, Maximiliano A Wilson, Robert Jr Laforce, Carol Hudon, Joël Macoir
Object decision (OD) test is one subtest of the Birmingham Object Recognition Battery (BORB). It is useful for differential diagnosis among several neurodegenerative diseases. However, normative data provided with this battery count on very few subjects and do not control for the effect of age, which limits interpretability. The purpose of Study 1 was to provide normative data for the OD test of the BORB (version A-hard). The objectives of Study 2 were to establish the diagnostic validity of this task and predictive validity of the normative data in the case of the semantic variant of primary progressive aphasia (svPPA) and Alzheimer's disease (AD)...
April 21, 2017: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
https://www.readbyqxmd.com/read/28425216/pneumonia-risk-in-asthma-patients-using-inhaled-corticosteroids-a-quasi-cohort-study
#19
Christina J Qian, Janie Coulombe, Samy Suissa, Pierre Ernst
AIM: Studies have linked the use of inhaled corticosteroids (ICS) to excess pneumonia risk in COPD patients. The risk in asthma patients remains unclear. The objective was to examine the risk of pneumonia with ICS in patients 12 to 35 years old with asthma. METHODS: We formed a cohort of asthma patients treated from 1990-2007 using Quebec health insurance databases. Subjects were considered currently exposed if they had an ICS dispensed within the 60 days prior to their pneumonia index event or matched person-moment...
March 28, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28416901/mechanical-efficiency-in-children-with-different-body-weight-a-longitudinal-assessment-of-the-quality-cohort
#20
G Jabbour, A Tremblay, M Henderson, M-E Mathieu
Net mechanical efficiency (MEnet), which reflects the body's ability to transfer energy above resting levels in external work, is similar in young children regardless of their body weights. However, it is unclear whether MEnet remains stable during growth and maturation. We sought to determine whether net mechanical efficiency (MEnet) changes over a period of 3 years in children and to identify the factors associated with possible changes. A total of 169 children participating in the QUALITY (Quebec Adipose and Lifestyle InvesTigation in Youth) cohort completed an incremental cycling test, resulting in the same maximal power output during both visits...
March 2017: Biology of Sport
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