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https://www.readbyqxmd.com/read/29338743/the-prospective-and-concurrent-effect-of-exercise-on-health-related-quality-of-life-in-older-adults-over-a-3%C3%A2-year-period
#1
Helen-Maria Vasiliadis, Mathieu F Bélanger
BACKGROUND: It is not clear whether socioeconomic status influences health outcomes among older adults through its effect on physical activity. The aim of this study was to assess the effect of sex and neighborhood socio-economic status on the change in health related quality of life (HR-QOL) as a function of physical activity over a three-year period. METHODS: This cohort study included French-speaking community-dwelling older adults recruited in primary care practices in the province of Quebec and participating in the 'Étude sur la Santé des Ainés' (ESA)-Services study on the health of the elderly...
January 16, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29335261/childhood-trajectories-of-peer-victimization-and-prediction-of-mental-health-outcomes-in-midadolescence-a-longitudinal-population-based-study
#2
Marie-Claude Geoffroy, Michel Boivin, Louise Arseneault, Johanne Renaud, Léa C Perret, Gustavo Turecki, Gregory Michel, Julie Salla, Frank Vitaro, Mara Brendgen, Richard E Tremblay, Sylvana M Côté
BACKGROUND: Exposure to peer victimization is relatively common. However, little is known about its developmental course and its effect on impairment associated with mental illnesses. We aimed to identify groups of children following differential trajectories of peer victimization from ages 6 to 13 years and to examine predictive associations of these trajectories with mental health in adolescence. METHODS: Participants were members of the Quebec Longitudinal Study of Child Development, a prospective cohort of 2120 children born in 1997/98 who were followed until age 15 years...
January 15, 2018: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/29329508/hospital-readmissions-and-the-day-of-the-week
#3
Aman Verma, Christian Rochefort, Guido Powell, David Buckeridge
Objectives Patients discharged from hospitals on a Friday (Friday discharges) are readmitted sooner (a shorter time-to-emergency-readmission) than those discharged on any other day of the week. To evaluate the cost-effectiveness of increasing weekend capacity, the effect estimate of Friday discharge on time-to-emergency-readmission needs to be precise. However, precise effect estimation is complicated by the confounding effect of differing healthcare-seeking behaviour and admission practices, and therefore different admission probability, by day of the week...
January 2018: Journal of Health Services Research & Policy
https://www.readbyqxmd.com/read/29326876/mildly-elevated-succinylacetone-and-normal-liver-function-in-compound-heterozygotes-with-pathogenic-and-pseudodeficient-fah-alleles
#4
Hao Yang, Francis Rossignol, Denis Cyr, Rachel Laframboise, Shu Pei Wang, Jean-François Soucy, Marie-Thérèse Berthier, Yves Giguère, Paula J Waters, Grant A Mitchell
Background: A high level of succinylacetone (SA) in blood is a sensitive, specific marker for the screening and diagnosis of hepatorenal tyrosinemia (HT1, MIM 276700). HT1 is caused by mutations in the FAH gene, resulting in deficiency of fumarylacetoacetate hydrolase. HT1 newborns are usually clinically asymptomatic, but have coagulation abnormalities revealing liver dysfunction. Treatment with nitisinone (NTBC) plus dietary restriction of tyrosine and phenylalanine prevents the complications of HT1...
March 2018: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/29322311/minimally-invasive-transforaminal-lumbar-interbody-fusion-with-unilateral-pedicle-screw-fixation-unilif-morbidity-clinical-and-radiological-2-year-outcomes-of-a-66-patient-prospective-series
#5
H Giorgi, R Prebet, R Andriantsimiavona, P Tropiano, B Blondel, H F Parent
PURPOSE: To assess clinical and radiological outcomes at 2-year follow-up of one-level minimally invasive transforaminal interbody fusion with unilateral pedicle screw fixation (UNILIF) in the treatment of stable lumbar degenerative diseases. METHODS: From January 1, 2012 to January 31, 2013, we prospectively collected clinical and radiological data on patients with stable degenerative lumbar disease managed by UNILIF in a single institution. Preoperatively and at 2 years, we recorded ODI, SF-12, Quebec and VAS...
January 10, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29321047/effects-of-concentrated-long-chain-omega-3-polyunsaturated-fatty-acid-supplementation-before-radical-prostatectomy-on-prostate-cancer-proliferation-inflammation-and-quality-of-life-study-protocol-for-a-phase-iib-randomized-double-blind-placebo-controlled-trial
#6
Marie-Hélène Guertin, Karine Robitaille, Jean-François Pelletier, Thierry Duchesne, Pierre Julien, Josée Savard, Isabelle Bairati, Vincent Fradet
BACKGROUND: Prostate cancer is the most commonly diagnosed cancer in north-American men. Few dietary or lifestyle interventions have been tested to prevent prostate cancer progression. Omega-3 fatty acid supplementation represents a promising intervention for prostate cancer patients. The aim of the study is to evaluate the effects of long-chain omega-3 polyunsaturated fatty acids (LCn3), more precisely eicosapentaenoic acid monoacylglyceride (MAG-EPA) supplementation, on prostate cancer proliferation, inflammation mediators and quality of life among men who will undergo radical prostatectomy...
January 10, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29316862/-we-ve-been-here-for-2-000-years-white-settlers-native-american-dna-and-the-phenomenon-of-indigenization
#7
Darryl Leroux
Relying on a populace well-educated in family history based in ancestral genealogy, a robust national genomics sector has developed in Québec over the past decade-and-a-half. The same period roughly coincides with a fourfold increase in the number of individuals and organizations in the region self-identifying with a mixed-race form of indigeneity that is counter to existing Indigenous understandings of kinship and citizenship. This paper examines how recent efforts by genetic scientists, working on a multi-year research project on the 'diversity' of the Québec gene pool, intervene in complex settler-Indigenous relations by redefining indigeneity according to the logics of 'Native American DNA'...
January 1, 2018: Social Studies of Science
https://www.readbyqxmd.com/read/29313875/memo-efficacy-durability-and-effect-of-cognitive-training-and-psychosocial-intervention-in-individuals-with-mild-cognitive-impairment
#8
Sylvie Belleville, Carol Hudon, Nathalie Bier, Catherine Brodeur, Brigitte Gilbert, Sébastien Grenier, Marie-Christine Ouellet, Chantal Viscogliosi, Serge Gauthier
BACKGROUND/OBJECTIVES: There is no consensus on the efficacy of cognitive training in persons with mild cognitive impairment (MCI) because of the paucity of well-designed randomized controlled trials. The objective was to assess the effect of memory training on the cognitive functioning of persons with MCI and its durability and to evaluate whether this effect generalizes to daily life and whether positive effects could be obtained from psychosocial intervention. DESIGN: Single-blind randomized controlled trial...
January 4, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29310735/what-do-clinical-supervisors-require-to-teach-residents-in-family-medicine-how-to-care-for-seniors
#9
Anik M C Giguere, Paule Lebel, Michèle Morin, Françoise Proust, Charo Rodríguez, Valerie Carnovale, Louise Champagne, France Légaré, Pierre-Hugues Carmichael, Bernard Martineau, Philippe Karazivan, Pierre J Durand
We assessed clinicians' continuing professional development (CPD) needs at family practice teaching clinics in the province of Quebec. Our mixed methodology design comprised an environmental scan of training programs at four family medicine departments, an expert panel to determine priority clinical situations for senior care, a supervisors survey to assess their perceived CPD needs, and interviews to help understand the rationale behind their needs. From the environmental scan, the expert panel selected 13 priority situations...
January 9, 2018: Canadian Journal on Aging, la Revue Canadienne du Vieillissement
https://www.readbyqxmd.com/read/29304227/combining-environmental-investigation-and-a-dual-analytical-strategy-to-isolate-the-legionella-longbeachae-strain-linked-to-two-occupational-cases-of-legionellosis
#10
Genevieve Marchand, Judith Lord, Carole Pépin, Nancy Lacombe
Legionella has a global distribution, mainly in aquatic and man-made environments. Under the right conditions, this bacterium is a notorious human pathogen responsible for severe pulmonary illnesses. Legionellosis outbreaks are reported around the world, and exposure to water droplet aerosols containing Legionella pneumophila is usually the mechanism of its transmission. Even if L. pneumophila causes most outbreaks, Legionella longbeachae also accounts for some cases. Unlike most other Legionella strains, L...
January 3, 2018: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29298995/nuclear-receptor-gene-polymorphisms-and-warfarin-dose-requirements-in-the-quebec-warfarin-cohort
#11
Payman Shahabi, Félix Lamothe, Stéphanie Dumas, Étienne Rouleau-Mailloux, Yassamin Feroz Zada, Sylvie Provost, Geraldine Asselin, Ian Mongrain, Diane Valois, Marie-Josée Gaulin Marion, Louis-Philippe Lemieux Perreault, Sylvie Perreault, Marie-Pierre Dubé
Warfarin is primarily metabolized by cytochrome 2C9, encoded by gene CYP2C9. Here, we investigated whether variants in nuclear receptor genes which regulate the expression of CYP2C9 are associated with warfarin response. We used data from 906 warfarin users from the Quebec Warfarin Cohort (QWC) and tested the association of warfarin dose requirement at 3 months following the initiation of therapy in nine nuclear receptor genes: NR1I3, NR1I2, NR3C1, ESR1, GATA4, RXRA, VDR, CEBPA, and HNF4A. Three correlated SNPs in the VDR gene (rs4760658, rs11168292, and rs11168293) were associated with dose requirements of warfarin (P = 2...
January 3, 2018: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/29294745/gender-s-role-in-exposure-to-interparental-violence-acceptance-of-violence-self-efficacy-and-physical-teen-dating-violence-among-quebec-adolescents
#12
Catherine Ruel, Francine Lavoie, Martine Hébert, Martin Blais
Despite efforts to prevent physical teen dating violence, it remains a major public health issue with multiple negative consequences. This study aims to investigate gender differences in the relationships between exposure to interparental violence (mother-to-father violence, father-to-mother violence), acceptance of dating violence (perpetrated by boys, perpetrated by girls), and self-efficacy to disclose teen dating violence. Data were drawn from Waves 1 and 2 of the Quebec Youth Romantic Relationships Project, conducted with a representative sample of Quebec high school students...
May 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29290447/herd-level-prevalence-of-the-ultrasonographic-lung-lesions-associated-with-bovine-respiratory-disease-and-related-environmental-risk-factors
#13
S Buczinski, M E Borris, J Dubuc
Bovine respiratory disease complex (BRD) is a major calf disease during the preweaning period. Thoracic ultrasound (TUS) has been recently described as a reliable tool for assessing BRD-associated lung lesions. The objectives of this study were to define the herd-level prevalence of lung consolidation assessed by TUS (CONSTUS). A total of 39 Québec dairy herds were randomly chosen to participate in this cross-sectional study. Between 6 and 12 preweaned calves were examined for signs of CONSTUS defined by any site with ≥3 cm consolidated lung tissue during 1 visit in summer and 1 visit in winter...
December 28, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29283390/genotypic-and-phylogenetic-insights-on-prevention-of-the-spread-of-hiv-1-and-drug-resistance-in-real-world-settings
#14
REVIEW
Bluma G Brenner, Ruxandra-Ilinca Ibanescu, Isabelle Hardy, Michel Roger
HIV continues to spread among vulnerable heterosexual (HET), Men-having-Sex with Men (MSM) and intravenous drug user (IDU) populations, influenced by a complex array of biological, behavioral and societal factors. Phylogenetics analyses of large sequence datasets from national drug resistance testing programs reveal the evolutionary interrelationships of viral strains implicated in the dynamic spread of HIV in different regional settings. Viral phylogenetics can be combined with demographic and behavioral information to gain insights on epidemiological processes shaping transmission networks at the population-level...
December 28, 2017: Viruses
https://www.readbyqxmd.com/read/29282361/influence-of-bcl2l11-polymorphism-on-osteonecrosis-during-treatment-of-childhood-acute-lymphoblastic-leukemia
#15
Maria Plesa, Vincent Gagné, Sanja Glisovic, Melissa Younan, Bahram Sharif-Askari, Caroline Laverdière, Nathalie Alos, Jean-Marie Leclerc, Stephen E Sallan, Donna Neuberg, Jeffery L Kutok, Lewis B Silverman, Daniel Sinnett, Maja Krajinovic
Osteonecrosis (ON) is corticosteroid-related complication, reported in children with acute lymphoblastic leukemia (ALL). We have previously found that polymorphisms in BCL2L11 gene coding for pro-apoptotic Bim protein influence reduction of overall survival (OS) in a corticosteroid (CS) dose-dependent manner in childhood ALL patients. The same set of SNPs was here investigated for an association with CS-related ON assessed retrospectively in 304 children with ALL from Quebec (QcALL cohort) who received Dana-Farber Cancer Institute (DFCI) ALL treatment protocols...
December 27, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/29281726/criteria-for-the-prioritization-of-public-health-interventions-for-climate-sensitive-vector-borne-diseases-in-quebec
#16
Valerie Hongoh, Pierre Gosselin, Pascal Michel, André Ravel, Jean-Philippe Waaub, Céline Campagna, Karim Samoura
Prioritizing resources for optimal responses to an ever growing list of existing and emerging infectious diseases represents an important challenge to public health. In the context of climate change, there is increasing anticipated variability in the occurrence of infectious diseases, notably climate-sensitive vector-borne diseases. An essential step in prioritizing efforts is to identify what considerations and concerns to take into account to guide decisions and thus set disease priorities. This study was designed to perform a comprehensive review of criteria for vector-borne disease prioritization, assess their applicability in a context of climate change with a diverse cross-section of stakeholders in order to produce a baseline list of considerations to use in this decision-making context...
2017: PloS One
https://www.readbyqxmd.com/read/29279747/prevalence-of-neuropathic-pain-and-patient-reported-outcomes-in-korean-adults-with-chronic-low-back-pain-resulting-from-neuropathic-low-back-pain
#17
Jin-Hwan Kim, Jae Taek Hong, Chong-Suh Lee, Keun-Su Kim, Kyung-Soo Suk, Jin-Hyok Kim, Ye-Soo Park, Bong-Soon Chang, Deuk Soo Jun, Young-Hoon Kim, Jung-Hee Lee, Woo-Kie Min, Jung-Sub Lee, Si-Young Park, In-Soo Oh, Jae-Young Hong, Hyun-Chul Shin, Woo-Kyung Kim, Joo-Han Kim, Jung-Kil Lee, In-Soo Kim, Yoon Ha, Soo-Bin Im, Sang Woo Kim, In-Ho Han, Jun-Jae Shin, Byeong Cheol Rim, Bo-Jeong Seo, Young-Joo Kim, Juneyoung Lee
Study Design: A noninterventional, multicenter, cross-sectional study. Purpose: We investigated the prevalence of neuropathic pain (NP) and patient-reported outcomes (PROs) of the quality of life (QoL) and functional disability in Korean adults with chronic low back pain (CLBP). Overview of Literature: Among patients with CLBP, 20%-55% had NP. Methods: Patients older than 20 years with CLBP lasting for longer than three months, with a visual analog scale (VAS) pain score higher than four, and with pain medications being used for at least four weeks before enrollment were recruited from 27 general hospitals between December 2014 and May 2015...
December 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/29277241/-evolution-of-paternal-filicide-suicide-in-the-province-of-quebec
#18
S Léveillée, L Doyon, M Cantinotti
OBJECTIVES: The purpose of this study was to specify the number of male filicide-suicide committed in the province of Quebec between 1997 and 2012, and to evaluate whether there has been an increase in the number of male filicide-suicide according to the period studied and the type of motivation to commit the crime. METHOD: The data cover all officially registered male filicides committed in the province of Quebec from 1997 to 2012, against youths under 18 years old...
December 22, 2017: L'Encéphale
https://www.readbyqxmd.com/read/29276161/impact-of-vaccination-history-on-serological-testing-in-pregnant-women
#19
Michaël Desjardins, Isabelle Boucoiran, Caroline Paquet, Céline Laferrière, Anne Gosselin-Brisson, Annie-Claude Labbé, Valérie Martel-Laferrière
OBJECTIVE: Serological testing guidelines for vaccine-preventable infectious diseases in pregnant women are heterogeneous. It is unclear how vaccination history influences health care workers' (HCWs) attitudes about testing. The aim of this study was to describe current practices in screening for rubella, hepatitis B, and varicella-zoster virus (VZV) in pregnant women in the province of Québec. METHODS: In 2015, an electronic survey was distributed to HCWs who followed the case of at least one pregnant woman in the previous year and who could be contacted by email by their professional association...
December 21, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29274605/alexithymia-as-a-mediator-of-the-relationship-between-child-sexual-abuse-and-psychological-distress-in-adolescence-a-short-term-longitudinal-study
#20
Martine Hébert, Cyndi Boisjoli, Martin Blais, Essaïd Oussaïd
BACKGROUND: Understanding factors influencing mental health of sexually abused teenagers is essential to orient treatment with this vulnerable population. The purpose of this study was to explore alexithymia as a mediator of the relationship between child sexual abuse and psychological distress using a representative sample of teenagers, while considering gender as a potential moderator. METHODS: Teenagers participating in the Quebec Youths' Romantic Relationships Survey completed measures evaluating a history of child sexual abuse and alexithymia at baseline while psychological distress was evaluated 6 months later...
December 14, 2017: Psychiatry Research
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