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https://www.readbyqxmd.com/read/29933318/organochlorine-levels-in-plasma-and-risk-of-multiple-myeloma-organochlorines-and-risk-of-multiple-myeloma
#1
Leah Weber, Kevin Song, Terry Boyle, Éric Gaudreau, Agnes Lai, Heather J Sutherland, Alain Leblanc, John J Spinelli
OBJECTIVE: To estimate the association between organochlorine pesticides and polychlorinated biphenyls (PCBs) and multiple myeloma (MM). METHODS: The risk of MM from organochlorine compounds was examined in a population-based case-control study in British Columbia, Canada. Congeners of PCBs and pesticides or pesticide metabolites were measured in plasma of 325 cases and 327 controls. RESULTS: Most organochlorine analytes showed a significant association with MM...
June 21, 2018: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29932838/optimization-and-improvement-of-in-line-filtration-performance-in-water-treatment-for-a-typical-low-turbidity-source-water
#2
Ding Wang, Kelsey L Kundert, Monica B Emelko
Forest catchments can produce high quality source water with a low turbidity. However, the combination of low turbidity, low organic carbon, and low temperature water conditions presents operating challenges in conventional water treatment processes. In this study, in-line filtration was tested using pilot-scale filter columns, and was found to be an appropriate option to treat a typical low turbidity water originating from the Rocky Mountains near Calgary, Alberta, Canada. When alum and cationic polymer were dosed simultaneously, in-line filtration produced high quality effluent with a turbidity and a particle count value of less than 0...
June 22, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29932832/prevalence-of-skin-tears-among-frail-older-adults-living-in-canadian-long-term-care-facilities
#3
Kevin Woo, Kim LeBlanc
OBJECTIVES: To explore the prevalence of skin tears in the Canadian long-term care (LTC) population. SUBJECTS AND SETTING: The setting included 678 residents residing in four LTC facilities in western Canada. DESIGN: A cross-sectional prevalence study to establish the prevalence of skin tears in four LTC facilities in Canada. RESULTS: The prevalence of skin tears was 14.7%. Primary associated risk factors included advanced age, being male and having an increased pressure ulcer risk...
June 2, 2018: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/29932800/hepatitis-c-testing-status-and-treatment-among-marginalized-people-who-use-drugs-in-an-inner-city-setting-an-observational-cohort-study
#4
Lisa M Boucher, Ahmed M Bayoumi, Amy E Mark, Curtis Cooper, Alana Martin, Zack Marshall, Rob Boyd, Pam Oickle, Nicola Diliso, Dave Pineau, Brad Renaud, Sean LeBlanc, Mark Tyndall, Olivia M Lee, Claire E Kendall
BACKGROUND: Chronic hepatitis C virus (HCV) infection is common among people who inject drugs (PWID) and is associated with morbidity and premature death. Although HCV can be cured, treatment may be inaccessible. We studied HCV testing, status and treatment among marginalized people who use drugs in Ottawa, Canada, a setting with universal insurance coverage for physician services. METHODS: We analyzed data from the Participatory Research in Ottawa: Understanding Drugs study, a cross-sectional, peer-administered survey of people who use drugs from 2012 to 2013...
June 22, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29932455/mobile-phone-based-interventions-for-improving-adherence-to-medication-prescribed-for-the-primary-prevention-of-cardiovascular-disease-in-adults
#5
REVIEW
Melissa J Palmer, Sharmani Barnard, Pablo Perel, Caroline Free
BACKGROUND: Cardiovascular disease (CVD) is a major cause of disability and mortality globally. Premature fatal and non-fatal CVD is considered to be largely preventable through the control of risk factors via lifestyle modifications and preventive medication. Lipid-lowering and antihypertensive drug therapies for primary prevention are cost-effective in reducing CVD morbidity and mortality among high-risk people and are recommended by international guidelines. However, adherence to medication prescribed for the prevention of CVD can be poor...
June 22, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29932134/assessment-of-the-canadian-children-s-food-and-beverage-advertising-initiative-s-uniform-nutrition-criteria-for-restricting-children-s-food-and-beverage-marketing-in-canada
#6
Christine Mulligan, Marie-Ève Labonté, Laura Vergeer, Mary R L'Abbé
Imposing governmental restrictions on the marketing of unhealthy foods and beverages to children is a demanded policy action since in Canada, this remains self-regulated by the voluntary, industry-led Canadian Children’s Food and Beverage Advertising Initiative (CAI) whose participants pledge to only advertise products that satisfy its Uniform Nutrition Criteria to children. This study evaluated the stringency of this nutrient profiling (NP) model for restricting child-directed food and beverage marketing in Canada...
June 22, 2018: Nutrients
https://www.readbyqxmd.com/read/29931166/sepsis-now-a-priority-a-quality-improvement-initiative-for-early-sepsis-recognition-and-care
#7
Christine M McDonald, Sarah West, David Dushenski, Stephen E Lapinsky, Christine Soong, Kate van den Broek, Melanie Ashby, Gillian Wilde-Friel, Carrie Kan, Mark McIntyre, Andrew Morris
Objective: To develop a triage-based screening algorithm and treatment order-sets aimed at improving the quality of care of all patients with sepsis presenting to our emergency department (ED). Design: Retrospective cohort study conducted during a pre-intervention period from 1 April 2010 to 31 March 2011 and a post-intervention period from 1 September 2014 to 30 April 2015. Setting: A large teaching hospital located in Toronto, Ontario, Canada with a 35-bed ED...
June 20, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29929953/sex-ratios-at-birth-among-second-generation-mothers-of-south-asian-ethnicity-in-ontario-canada-a-retrospective-population-based-cohort-study
#8
Susitha Wanigaratne, Pamela Uppal, Manvir Bhangoo, Alia Januwalla, Deepa Singal, Marcelo L Urquia
BACKGROUND: Son-biased sex ratios at birth (M:F), an extreme manifestation of son preference, are predominately found in East and South Asia. Studies have examined sex ratios among first-generation migrants from these regions, but few have examined second-generation descendants. Our objective was to determine whether son-biased sex ratios persist among second-generation mothers with South Asian ethnicity in Ontario, Canada. METHODOLOGY: A surname algorithm identified a population-based cohort of mothers with South Asian ethnicity who gave birth in Ontario between 1993 and 2014 (n=59 659)...
June 21, 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29929874/maternal-and-infant-outcomes-associated-with-lithium-use-in-pregnancy-an-international-collaborative-meta-analysis-of-six-cohort-studies
#9
Trine Munk-Olsen, Xiaoqin Liu, Alexander Viktorin, Hilary K Brown, Arianna Di Florio, Brian M D'Onofrio, Tara Gomes, Louise M Howard, Hind Khalifeh, Holly Krohn, Henrik Larsson, Paul Lichtenstein, Clare L Taylor, Inge Van Kamp, Richard Wesseloo, Samantha Meltzer-Brody, Simone N Vigod, Veerle Bergink
BACKGROUND: Concerns about teratogenicity and maternal and offspring complications restrict the use of lithium during pregnancy for the treatment of mood disorders. We aimed to investigate the association between in-utero lithium exposure and risk of pregnancy complications, delivery outcomes, neonatal morbidity, and congenital malformations. METHODS: In this meta-analysis, primary data from pregnant women and their children from six international cohorts based in the community (Denmark, Sweden, and Ontario, Canada) and in clinics (the Netherlands, UK, and USA) were analysed...
June 18, 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29929565/use-of-hospitals-by-older-versus-younger-canadians-myths-and-misconceptions
#10
Donna M Wilson, Ye Shen, Gail Low
ABSTRACTThis study investigated concerns regarding the extensive use of hospitals by older people and subsequent long wait lists. We analysed complete individual-anonymous, 2014-2015 inpatient hospital data for all Canadian provinces and territories (except Quebec). People aged 65 and older accounted for 37.0 per cent of all hospital episodes and 41.5 per cent of all admissions to intensive or coronary care units. Similarly, of all admitted individuals, 32.8 per cent were older. The data also revealed only 14...
June 22, 2018: Canadian Journal on Aging, la Revue Canadienne du Vieillissement
https://www.readbyqxmd.com/read/29929388/mental-health-in-the-cree-peoples-of-northern-quebec-relationships-among-trauma-familial-psychological-distress-and-mood-or-anxiety-disorders
#11
Laura M Heath, Jill Torrie, Kathryn J Gill
OBJECTIVE: This study examined the physical and mental health of Cree adults, as well as the personal, clinical, and environmental factors associated with the presence of lifetime anxiety and mood disorders. METHODS: Mental health was assessed using the computerised version of the Diagnostic Interview Schedule (CDIS-IV), and standardised instruments were used to assess physical health, addiction severity, and psychological distress in 506 randomly selected participants from 4 Northern Cree communities in Quebec...
January 1, 2018: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/29929386/early-adolescent-substance-use-and-mental-health-problems-and-service-utilisation-in-a-school-based-sample
#12
Elizabeth Brownlie, Joseph H Beitchman, Gloria Chaim, David A Wolfe, Brian Rush, Joanna Henderson
OBJECTIVE: This paper reports on substance use, mental health problems, and mental health service utilisation in an early adolescent school-based sample. METHOD: Participants were 1,360 grade 7 and 8 students from 4 regions of Ontario, Canada. Students completed an in-class survey on mental health and substance use. The sampling strategy and survey items on demographics, substance use, service utilisation, and distress were adapted from the Ontario Student Drug Use and Health Survey...
January 1, 2018: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/29929317/chronic-effects-of-an-environmentally-relevant-short-term-neonicotinoid-insecticide-pulse-on-four-aquatic-invertebrates
#13
Melanie Raby, Xiaoming Zhao, Chunyan Hao, David G Poirier, Paul K Sibley
Neonicotinoid insecticides used in agriculture can enter freshwater environments in pulses; that is, a short-term period of a higher concentration, followed by a period of a comparatively lower concentration. Non-target aquatic arthropods are exposed to these fluctuating concentrations of neonicotinoids. The present study investigated the potential latent effects of a single environmentally-relevant 24-h pulse of imidacloprid and thiamethoxam, in separate experiments, on the early life-stages of four aquatic arthropods (Hyalella azteca, Chironomus dilutus, Hexagenia spp...
October 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29928996/study-protocol-mobilizing-asian-men-in-canada-to-reduce-stigma-of-mental-illness
#14
Sepali Guruge, Kenneth Po-Lun Fung, Souraya Sidani, David Este, Marina Morrow, Kwame McKenzie, Josephine Pui-Hing Wong
BACKGROUND: The available evidence on interventions addressing the stigma of mental illness is limited because of small samples, lack of diversity in study samples, and exclusion of people living with mental illness. To date, no published studies have evaluated anti-stigma interventions for Asian men in Canada. Aim This paper describes the protocol of a study to evaluate psychological and collective empowerment interventions (ACT, CEE, and ACT+CEE) in addressing self-stigma and social stigma in Asian communities in three urban settings in Canada: Toronto, Calgary and Vancouver...
June 18, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29928525/priority-setting-for-occupational-cancer-prevention
#15
Cheryl E Peters, Alison L Palmer, Joanne Telfer, Calvin B Ge, Amy L Hall, Hugh W Davies, Manisha Pahwa, Paul A Demers
Background: Selecting priority occupational carcinogens is important for cancer prevention efforts; however, standardized selection methods are not available. The objective of this paper was to describe the methods used by CAREX Canada in 2015 to establish priorities for preventing occupational cancer, with a focus on exposure estimation and descriptive profiles. Methods: Four criteria were used in an expert assessment process to guide carcinogen prioritization: (1) the likelihood of presence and/or use in Canadian workplaces; (2) toxicity of the substance (strength of evidence for carcinogenicity and other health effects); (3) feasibility of producing a carcinogen profile and/or an occupational estimate; and (4) special interest from the public/scientific community...
June 2018: Safety and Health At Work
https://www.readbyqxmd.com/read/29928300/genotyping-by-sequencing-of-genome-wide-microsatellite-loci-reveals-fine-scale-harvest-composition-in-a-coastal-atlantic-salmon-fishery
#16
Ian R Bradbury, Brendan F Wringe, Beth Watson, Ian Paterson, John Horne, Robert Beiko, Sarah J Lehnert, Marie Clément, Eric C Anderson, Nicholas W Jeffery, Steven Duffy, Emma Sylvester, Martha Robertson, Paul Bentzen
Individual assignment and genetic mixture analysis are commonly utilized in contemporary wildlife and fisheries management. Although microsatellite loci provide unparalleled numbers of alleles per locus, their use in assignment applications is increasingly limited. However, next-generation sequencing, in conjunction with novel bioinformatic tools, allows large numbers of microsatellite loci to be simultaneously genotyped, presenting new opportunities for individual assignment and genetic mixture analysis. Here, we scanned the published Atlantic salmon genome to identify 706 microsatellite loci, from which we developed a final panel of 101 microsatellites distributed across the genome (average 3...
July 2018: Evolutionary Applications
https://www.readbyqxmd.com/read/29928298/optimization-and-performance-testing-of-a-sequence-processing-pipeline-applied-to-detection-of-nonindigenous-species
#17
Ryan Scott, Aibin Zhan, Emily A Brown, Frédéric J J Chain, Melania E Cristescu, Robin Gras, Hugh J MacIsaac
Genetic taxonomic assignment can be more sensitive than morphological taxonomic assignment, particularly for small, cryptic or rare species. Sequence processing is essential to taxonomic assignment, but can also produce errors because optimal parameters are not known a priori. Here, we explored how sequence processing parameters influence taxonomic assignment of 18S sequences from bulk zooplankton samples produced by 454 pyrosequencing. We optimized a sequence processing pipeline for two common research goals, estimation of species richness and early detection of aquatic invasive species (AIS), and then tested most optimal models' performances through simulations...
July 2018: Evolutionary Applications
https://www.readbyqxmd.com/read/29928296/genomewide-evidence-of-environmentally-mediated-secondary-contact-of-european-green-crab-carcinus-maenas-lineages-in-eastern-north-america
#18
Nicholas W Jeffery, Ian R Bradbury, Ryan R E Stanley, Brendan F Wringe, Mallory Van Wyngaarden, J Ben Lowen, Cynthia H McKenzie, Kyle Matheson, Philip S Sargent, Claudio DiBacco
Genetic-environment associations are increasingly revealed through population genomic data and can occur through a number of processes, including secondary contact, divergent natural selection, or isolation by distance. Here, we investigate the influence of the environment, including seasonal temperature and salinity, on the population structure of the invasive European green crab ( Carcinus maenas ) in eastern North America. Green crab populations in eastern North America are associated with two independent invasions, previously shown to consist of distinct northern and southern ecotypes, with a contact zone in southern Nova Scotia, Canada...
July 2018: Evolutionary Applications
https://www.readbyqxmd.com/read/29928146/therapeutic-potential-of-medicinal-marijuana-an-educational-primer-for-health-care-professionals
#19
REVIEW
Yara Mouhamed, Andrey Vishnyakov, Bessi Qorri, Manpreet Sambi, Sm Signy Frank, Catherine Nowierski, Anmol Lamba, Umrao Bhatti, Myron R Szewczuk
With the proposed Canadian July 2018 legalization of marijuana through the Cannabis Act, a thorough critical analysis of the current trials on the efficacy of medicinal marijuana (MM) as a treatment option is necessary. This review is particularly important for primary care physicians whose patients may be interested in using MM as an alternative therapy. In response to increased interest in MM, Health Canada released a document in 2013 for general practitioners (GPs) as an educational tool on the efficacy of MM in treating some chronic and acute conditions...
2018: Drug, Healthcare and Patient Safety
https://www.readbyqxmd.com/read/29927964/the-spread-of-kalmia-angustifolia-on-black-spruce-forest-cutovers-contributes-to-the-spatial-heterogeneity-of-soil-resources
#20
Gilles D Joanisse, Robert L Bradley, Caroline M Preston
Kalmia angustifolia is a boreal ericaceous shrub that can rapidly spread on black spruce forest cutovers in eastern Canada, where CPRS (i.e. Cutting with Protection of Regeneration and Soils") is practiced. The proliferation of Kalmia often coincides with a reduction in the growth rate of regenerating black spruce seedlings. We report on a study where we compared the local effects of Kalmia and black spruce seedling patches (i.e. two types of "Vegetation") on chemical and biochemical soil properties in CPRS cutovers within mesic spruce-moss and xeric spruce-lichen ecosystems, as well as in four mature spruce-moss forests (i...
2018: PloS One
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