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https://www.readbyqxmd.com/read/28324922/the-clinical-significance-of-occult-gastrointestinal-primary-tumours-in-metastatic-cancer-a-population-retrospective-cohort-study
#1
Malek B Hannouf, Eric Winquist, Salaheddin M Mahmud, Muriel Brackstone, Sisira Sarma, George Rodrigues, Peter K Rogan, Jeffrey S Hoch, Gregory S Zaric
Purpose: To estimate the incidence of occult gastrointestinal (GI) primary tumours in patients with metastatic cancer of uncertain primary origin and evaluate their influence on treatments and overall survival (OS). Materials and Methods: We used population heath data from Manitoba, Canada to identify all patients initially diagnosed with metastatic cancer between 2002 and 2011. We defined patients to have "occult" primary tumour if the primary was found at least 6 months after initial diagnosis...
March 21, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28324814/risk-of-injury-from-alcohol-marijuana-and-other-drug-use-among-emergency-department-patients
#2
Cheryl J Cherpitel, Yu Ye, Gabriel Andreuccetti, Tim Stockwell, Kate Vallance, Clifton Chow, Jeffrey R Brubacher
BACKGROUND: Alcohol is known to be associated with injury, but little is known of combined use of alcohol and other drugs on injury; especially important for marijuana, given increasing legalization of use in the U.S. and Canada. METHODS: Probability samples of patients 18 and older were interviewed in the emergency department at two sites in Vancouver and one in Victoria, BC (n=1191 injured and 1613 non-injured patients). Case-control and case-crossover analyses were used to analyze risk of injury, based on self-reported alcohol and drug use (marijuana, stimulants, depressants) prior to injury...
March 7, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28324326/the-impact-of-fabry-disease-on-reproductive-fitness
#3
Dawn A Laney, Virginia Clarke, Allison Foley, Eric W Hall, Scott E Gillespie, Myrl Holida, Morgan Simmons, Alexandrea Wadley
Fabry disease (FD) is a pan-ethnic, X-linked, progressive lysosomal storage disorder caused by pathogenic mutations in the GLA gene. Published case reports and abstracts suggest that decreased reproductive fitness may occur in males with FD. In order to understand the impact of FD on reproductive fitness and increase the accuracy of reproductive genetic counseling, this study examines a large, multi-centered population of individuals with FD to determine if males have reduced reproductive fitness. Study data were collected on 376 patients through two, gender-specific surveys distributed across the United States and Canada...
March 22, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28324205/levels-of-intervention-how-are-they-used-in-quebec-hospitals
#4
Marjolaine Frenette, Jocelyne Saint-Arnaud, Karim Serri
In order to promote better practices and communication around end-of-life decision-making, several Canadian hospitals in the province of Quebec have developed a tool called "Levels of Intervention" (LOI). No work to date has been published demonstrating improvement since these forms were implemented. The purpose of the present study was to obtain information about the use of LOI forms across Quebec hospitals and to identify gaps in practice as well as areas for improvement. A retrospective study was undertaken of 299 charts of patients who had died in three Quebec hospitals with a LOI ordered...
March 21, 2017: Journal of Bioethical Inquiry
https://www.readbyqxmd.com/read/28324114/novel-25-kb-deletion-of-mertk-causes-retinitis-pigmentosa-with-severe-progression
#5
Daniel R Evans, Jane S Green, Gordon J Johnson, Jeremy Schwartzentruber, Jacek Majewski, Chandree L Beaulieu, Wen Qin, Christian R Marshall, Tara A Paton, Nicole M Roslin, Andrew D Paterson, Somayyeh Fahiminiya, Justin French, Kym M Boycott, Michael O Woods
Purpose: Retinitis pigmentosa (RP) describes a complex group of inherited retinal dystrophies with almost 300 reported genes and loci. We investigated the genetic etiology of autosomal recessive RP (arRP) in a large kindred with 5 affected family members, who reside on the island of Newfoundland, Canada. Methods: Genetic linkage analysis was performed on 12 family members (Infinium HumanOmni2.5-8 BeadChip). Whole exome sequencing analysis (Illumina HiSeq) was performed on one affected individual...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28323771/an-exception-to-the-rule-or-a-rule-for-the-exception-the-potential-of-using-hiv-positive-donors-in-canada
#6
Alissa J Wright, Caren Rose, Maeghan Toews, Michel Paquet, Daniel Corsilli, Jean-François Le Cailhier, John S Gill
Selected human immunodeficiency virus (HIV)-infected patients with end organ failure can safely receive an organ transplant from an HIV uninfected donor. Recent demonstration of the short term safety of organ transplantation between HIV-infected persons prompted a change in US American law to allow such transplantations. Prompted by the recent completion of the first organ transplantation between HIV-infected persons in Canada, we review Canadian law regarding the use of organs from HIV-infected donors, estimate the number of potential HIV-infected donors in Canada, and critically review considerations related to advancing organ transplantation from HIV-infected donors in Canada...
April 2017: Transplantation
https://www.readbyqxmd.com/read/28323553/examining-pediatric-care-for-newly-immigrated-families-perspectives-of-health-care-providers
#7
David Nicholas, Bonnie Fleming-Carroll, Michele Durrant, Jonathan Hellmann
Respect for the ethnicity and cultural background of families are important components of health care delivery. However, the needs of new immigrants in pediatric care systems remain under-addressed in the literature. This study utilized a qualitative approach of interpretive description to elicit the pediatric health care experiences and needs of new immigrants to Canada, from the perspective of health care providers who worked extensively with newcomers. Two focus groups of multidisciplinary health care providers were conducted in a tertiary-level pediatric hospital...
March 21, 2017: Social Work in Health Care
https://www.readbyqxmd.com/read/28322522/-il-canada-mette-al-bando-l-amianto-storica-sconfitta-di-una-delle-pi%C3%A3-potenti-lobby-industriali
#8
Benedetto Terracini
No abstract text is available yet for this article.
January 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28319806/description-of-flamella-daurica-n-sp-with-notes-on-the-phylogeny-of-the-genus-flamella-and-related-taxa
#9
Anna Glotova, Alexey Smirnov
A new species of naked amoebae, Flamella daurica (Amoebozoa, Conosa, Variosea), from the Russian Far East is studied and described. In addition, we isolated a strain, identified as Flamella aegyptia from Lake Ontario in Canada. Its SSU rRNA gene sequence is almost identical with that of the type strain, except for the presence of an intron in the SSU sequence. The phylogenetic analysis of a variosean alignment after inclusion of a number of environmental sequences found in GenBank confirmed that the species Talaepolella tubasferens Lahr 2012 is closely related to the Flamella clade but probably represents an independent genus and includes no less than two different species...
March 3, 2017: European Journal of Protistology
https://www.readbyqxmd.com/read/28319241/alzheimer-disease-signature-neurodegeneration-and-apoe-genotype-in-mild-cognitive-impairment-with-suspected-non-alzheimer-disease-pathophysiology
#10
Stefanie Schreiber, Frank Schreiber, Samuel N Lockhart, Andy Horng, Alexandre Bejanin, Susan M Landau, William J Jagust
Importance: There are conflicting results claiming that Alzheimer disease signature neurodegeneration may be more, less, or similarly advanced in individuals with β-amyloid peptide (Aβ)-negative (Aβ-) suspected non-Alzheimer disease pathophysiology (SNAP) than in Aβ-positive (Aβ+) counterparts. Objective: To examine patterns of neurodegeneration in individuals with SNAP compared with their Aβ+ counterparts. Design, Setting, and Participants: A longitudinal cohort study was conducted among individuals with mild cognitive impairment (MCI) and cognitively normal individuals receiving care at Alzheimer's Disease Neuroimaging Initiative sites in the United States and Canada for a mean follow-up period of 30...
March 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28319231/association-of-suicidality-and-depression-with-5%C3%AE-reductase-inhibitors
#11
Blayne Welk, Eric McArthur, Michael Ordon, Kelly K Anderson, Jade Hayward, Stephanie Dixon
Importance: There have been concerns raised by patients and regulatory agencies regarding serious psychiatric adverse effects associated with 5α-reductase inhibitors. Objective: To determine if there is an increased risk of suicide, self-harm, or depression among older men starting a 5α-reductase inhibitor for prostatic enlargement. Design, Setting, and Participants: A population-based, retrospective, matched cohort study using linked administrative data for 93 197 men ages 66 years or older (median [IQR] age, 75 [70-80] years) in Ontario, Canada, who initiated a new prescription for a 5α-reductase inhibitor during the study period (2003 through 2013)...
March 20, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28318940/uptake-of-community-pharmacist-delivered-medscheck-diabetes-medication-review-service-in-ontario-between-2010-and-2014
#12
Lori MacCallum, Giulia Consiglio, Linda MacKeigan, Lisa Dolovich
OBJECTIVES: The objective of the study was to describe the demographic and clinical characteristics of MedsCheck Diabetes (MCD) recipients in Ontario between program launch on September 1, 2010, and March 31, 2014. METHODS: This cohort study leveraged linked administrative claims data. Trends in MCD claims and recipient characteristics were examined. RESULTS: A total of 406,694 Ontarians (45.8% women) received an MCD, representing approximately half of all Ontarians with diabetes...
March 17, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28318910/predictors-of-cigarette-smoking-initiation-in-early-middle-and-late-adolescence
#13
Jennifer O'Loughlin, Erin K O'Loughlin, Robert J Wellman, Marie-Pierre Sylvestre, Erika N Dugas, Miguel Chagnon, Hartley Dutczak, Johanne Laguë, Jennifer J McGrath
PURPOSE: Little is known about age-related differences in risk factors for cigarette smoking initiation. We identified predictors of initiation in early, middle, and late adolescence from among sociodemographic factors, indicators of smoking in the social environment, psychological characteristics, lifestyle indicators, and perceived need for cigarettes. METHODS: Data were drawn from a longitudinal study of 1,801 children recruited at age 10-11 years from 29 elementary schools in Montreal, Canada...
March 15, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28318695/monitoring-water-quality-in-toronto-s-urban-stormwater-ponds-assessing-participation-rates-and-data-quality-of-water-sampling-by-citizen-scientists-in-the-freshwater-watch
#14
Andrew B Scott, Paul C Frost
From 2013 to 2015, citizen scientist volunteers in Toronto, Canada were trained to collect and analyze water quality in urban stormwater ponds. This volunteer sampling was part of the research program, FreshWater Watch (FWW), which aimed to standardize urban water sampling efforts from around the globe. We held training sessions for new volunteers twice yearly and trained a total of 111 volunteers. Over the course of project, ~30% of volunteers participated by collecting water quality data after the training session with 124 individual sampling events at 29 unique locations in Toronto, Canada...
March 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28318638/optical-coherence-tomography-guided-decisions-in-retinoblastoma-management
#15
Sameh E Soliman, Cynthia VandenHoven, Leslie D MacKeen, Elise Héon, Brenda L Gallie
PURPOSE: Assess the role of handheld optical coherence tomography (OCT) in guiding management decisions during diagnosis, treatment, and follow-up of eyes affected by retinoblastoma. DESIGN: Retrospective, noncomparative, single-institution case series. PARTICIPANTS: All children newly diagnosed with retinoblastoma from January 2011 to December 2015 who had an OCT session during their active treatment at The Hospital for Sick Children (SickKids) in Toronto, Canada...
March 15, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28318580/the-canadian-national-dairy-study-2015-adoption-of-milking-practices-in-canadian-dairy-herds
#16
E Belage, S Dufour, C Bauman, A Jones-Bitton, D F Kelton
Several studies have investigated which management practices have the greatest effect on udder health, but little information is available on how broadly the recommended milking practices are adopted across Canada. The National Dairy Study 2015 was designed to gather dairy cattle health and management data on dairy farms across Canada. The objectives of the present study were to describe the current proportions of adoption of milking practices on Canadian dairy farms, and identify factors associated with their use on farms...
March 16, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28318575/heritabilities-of-measured-and-mid-infrared-predicted-milk-fat-globule-size-milk-fat-and-protein-percentages-and-their-genetic-correlations
#17
A Fleming, F S Schenkel, A Koeck, F Malchiodi, R A Ali, M Corredig, B Mallard, M Sargolzaei, F Miglior
The objective of this study was to estimate the heritability of milk fat globule (MFG) size and mid-infrared (MIR) predicted MFG size in Holstein cattle. The genetic correlations between measured and predicted MFG size with milk fat and protein percentage were also investigated. Average MFG size was measured in 1,583 milk samples taken from 254 Holstein cows from 29 herds across Canada. Size was expressed as volume moment mean (D[4,3]) and surface moment mean (D[3,2]). Analyzed milk samples also had average MFG size predicted from their MIR spectral records...
March 16, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28318456/international-outbreak-of-multiple-salmonella-serotype-infections-linked-to-sprouted-chia-seed-powder-usa-and-canada-2013-2014
#18
R R Harvey, K E Heiman Marshall, L Burnworth, M Hamel, J Tataryn, J Cutler, K Meghnath, A Wellman, K Irvin, L Isaac, K Chau, A Locas, J Kohl, P A Huth, D Nicholas, E Traphagen, K Soto, L Mank, K Holmes-Talbot, M Needham, A Barnes, B Adcock, L Honish, L Chui, M Taylor, C Gaulin, S Bekal, B Warshawsky, L Hobbs, L R Tschetter, A Surin, S Lance, M E Wise, I Williams, L Gieraltowski
Salmonella is a leading cause of bacterial foodborne illness. We report the collaborative investigative efforts of US and Canadian public health officials during the 2013-2014 international outbreak of multiple Salmonella serotype infections linked to sprouted chia seed powder. The investigation included open-ended interviews of ill persons, traceback, product testing, facility inspections, and trace forward. Ninety-four persons infected with outbreak strains from 16 states and four provinces were identified; 21% were hospitalized and none died...
March 20, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28318418/sexuality-and-everydayness-in-a-transnational-context-toward-a-re-imagined-west-china-relationship
#19
Yingying Huang
This paper examines how Chinese immigrants to Canada perceive and experience sexuality in a transnational context as revealed in a qualitative study. It identifies cultural interactions and tensions between 'the West' and 'China' embedded in participants' sexual narratives. Three thematic aspects of sexuality are explored: different views toward 'relationships' and how sex is involved in different stages of a relationship; physical desire and sexual attraction based on individuals' dialogues with contemporaries and their own cross-racial dating experience; and perceptions of sexual risks associated with an increasing awareness of China's opening up, in particular risks associated with attitudes towards condom use...
March 20, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28318231/paraben-concentrations-in-maternal-urine-and-breast-milk-and-its-association-with-personal-care-product-use
#20
Mandy Fisher, Susan MacPherson, Joseph M Braun, Russ Hauser, Mark Walker, Mark Feeley, Ranjeeta Mallick, René Bérubé, Tye E Arbuckle
Parabens are broad-spectrum antimicrobial preservatives and fragrances used in a wide range of personal care products, pharmaceuticals, and food providing the opportunity for people to be exposed on a daily basis. In 2009-2010, 80 pregnant women from Ottawa Canada participated in the Plastics and Personal-Care Product Use in Pregnancy (P4) Study. A subset of women (n = 31) who provided multiple spot urine samples (n = 542) collected over two 24-h periods had their samples analyzed for methylparaben (MP), n-propylparaben (PP), ethylparaben (EP), butylparaben (BP), isobutylparaben (IBP), and benzylparaben (BzP)...
March 20, 2017: Environmental Science & Technology
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