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epigenetics and depression

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https://www.readbyqxmd.com/read/29748862/association-of-dna-methylation-in-bdnf-with-escitalopram-treatment-response-in-depressed-chinese-han-patients
#1
Peipei Wang, Cuizhen Zhang, Qinyu Lv, Chenxi Bao, Hong Sun, Guo Ma, Yiru Fang, Zhenghui Yi, Weimin Cai
PURPOSE: The neurotrophin brain-derived neurotrophic factor (BDNF) has been found to be associated with both the pathophysiology of depression and antidepressants response. Gene expression differences were partly mediated by SNP, which might be identified as a predictor of antidepressant response. In the present study, we attempt to identify whether DNA methylation, another factor known to affect gene transcription, might also predict antidepressant response. METHODS: A total of 85 depressed Chinese Han patients were followed-up 8 weeks after initiating escitalopram treatment...
May 10, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29747816/gangliosides-in-nerve-cell-specification
#2
Yutaka Itokazu, Jing Wang, Robert K Yu
The central nervous system is generated from progenitor cells that are recognized as neural stem cells (NSCs). NSCs are defined as undifferentiated neural cells that are characterized by the capacity for self-renewal and multipotency. Throughout neural development, NSCs undergo proliferation, migration, and cellular differentiation, and dynamic changes are observed in the composition of carbohydrate-rich molecules, including gangliosides. Gangliosides are sialic acid-containing glycosphingolipids with essential and multifaceted functions in brain development and NSC maintenance, which reflects the complexity of brain development...
2018: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/29738444/the-effects-of-trauma-with-or-without-ptsd-on-the-transgenerational-dna-methylation-alterations-in-human-offsprings
#3
REVIEW
Nagy A Youssef, Laura Lockwood, Shaoyong Su, Guang Hao, Bart P F Rutten
Exposure to psychological trauma is a strong risk factor for several debilitating disorders including post-traumatic stress disorder (PTSD) and depression. Besides the impact on mental well-being and behavior in the exposed individuals, it has been suggested that psychological trauma can affect the biology of the individuals, and even have biological and behavioral consequences on the offspring of exposed individuals. While knowledge of possible epigenetic underpinnings of the association between exposure to trauma and risk of PTSD has been discussed in several reviews, it remains to be established whether trauma-induced epigenetic modifications can be passed from traumatized individuals to subsequent generations of offspring...
May 8, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29707086/epigenetics-of-metabolic-syndrome-as-a-mood-disorder
#4
REVIEW
Sermin Kesebir
Mood disorders comprise major depressive disorder (MDD), bipolar disorder (BD) and the milder forms of these two disorders. Reccurring MDD is also known as unipolar disorder. The distinction between unipolar and bipolar disorders was first suggested in 1957 by Leonard and was made official after support by several studies in 1980. Indeed, in 150 AD, Aretaeus of Cappadocia wrote "It seems to me that melancholia is the beginning and a part of mania". Additionally, Kraepelin, who proposed the first medical disease model in psychiatry a century ago, considered recurrent unipolar depression cases under the category of bipolar disorder and conceptualized spectrum disorders...
June 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29706161/the-epigenetic-clock-at-birth-associations-with-maternal-antenatal-depression-and-child-psychiatric-problems
#5
Anna Suarez, Jari Lahti, Darina Czamara, Marius Lahti-Pulkkinen, Anna K Knight, Polina Girchenko, Esa Hämäläinen, Eero Kajantie, Jari Lipsanen, Hannele Laivuori, Pia M Villa, Rebecca M Reynolds, Alicia K Smith, Elisabeth B Binder, Katri Räikkönen
OBJECTIVE: Maternal antenatal depression may compromise the fetal developmental milieu and contribute to individual differences in aging and disease trajectories in later life. We evaluated the association between maternal antenatal depression and a novel biomarker of aging at birth, namely epigenetic gestational age (GA) based on fetal cord blood methylation data. We also examined whether this biomarker prospectively predicts and mediates maternal effects on early childhood psychiatric problems...
May 2018: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29705127/genomic-methylation-and-transcriptomic-profiling-provides-insights-into-heading-depression-in-inbred-brassica-rapa-l-ssp-pekinensis
#6
Yan Liu, Cui Xu, Xuebing Tang, Surui Pei, Di Jin, Minghao Guo, Meng Yang, Yaowei Zhang
Inbreeding depression is the reduction in fitness observed in inbred populations. In plants, it leads to disease, weaker resistance to adverse environmental conditions, inhibition of growth, and decrease of yield. To elucidate molecular mechanisms behind inbreeding depression, we compared global DNA methylation and transcriptome profiles of a normal and a highly inbred heading degenerated variety of the Chinese cabbage (Brassica rapa L. ssp. pekinensis). DNA methylation was reduced in inbred plants, suggesting a change in the epigenetic landscape...
April 26, 2018: Gene
https://www.readbyqxmd.com/read/29701114/blood-biomarkers-and-treatment-response-in-major-depression
#7
Cristina Mora, Valentina Zonca, Marco A Riva, Annamaria Cattaneo
Millions of people worldwide suffer from depression, but despite advances in pharmacological therapies, many patients do not experience symptomatic remission or treatment response, even after treatments with several medications. As such, there is an urgent need to identify biomarkers that can not only predict the treatment response, but also allow a rational selection of optimal therapy for each patient. Areas covered: This review examines the recent findings, coming from different "omic sciences", in human blood-based biomarkers associated with antidepressant treatment response with particular attention on genetic/epigenetic and biochemical biomarkers...
April 27, 2018: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29685134/oral-sensitization-to-whey-proteins-induces-age-and-sex-dependent-behavioral-abnormality-and-neuroinflammatory-responses-in-a-mouse-model-of-food-allergy-a-potential-role-of-mast-cells
#8
Danielle L Germundson, Nicholas A Smith, Lane P Vendsel, Andrea V Kelsch, Colin K Combs, Kumi Nagamoto-Combs
BACKGROUND: Growing evidence has strengthened the association of food allergy with neuropsychiatric symptoms such as depression, anxiety, and autism. However, underlying mechanisms by which peripheral allergic responses lead to behavioral dysfunction are yet to be determined. Allergen-activated mast cells may serve as mediators by releasing histamine and other inflammatory factors that could adversely affect brain function. We hypothesized that eliciting food allergy in experimental animals would result in behavioral changes accompanied by mast cell accumulation in the brain...
April 23, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29656664/epigenetic-aging-in-major-depressive-disorder
#9
Laura K M Han, Moji Aghajani, Shaunna L Clark, Robin F Chan, Mohammad W Hattab, Andrey A Shabalin, Min Zhao, Gaurav Kumar, Lin Ying Xie, Rick Jansen, Yuri Milaneschi, Brian Dean, Karolina A Aberg, Edwin J C G van den Oord, Brenda W J H Penninx
OBJECTIVE: Major depressive disorder is associated with an increased risk of mortality and aging-related diseases. The authors examined whether major depression is associated with higher epigenetic aging in blood as measured by DNA methylation (DNAm) patterns, whether clinical characteristics of major depression have a further impact on these patterns, and whether the findings replicate in brain tissue. METHOD: DNAm age was estimated using all methylation sites in blood of 811 depressed patients and 319 control subjects with no lifetime psychiatric disorders and low depressive symptoms from the Netherlands Study of Depression and Anxiety...
April 16, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29650294/increased-methylation-at-an-unexplored-glucocorticoid-responsive-element-within-exon-1-d-of-nr3c1-gene-is-related-to-anxious-depressive-disorders-and-decreased-hippocampal-connectivity
#10
Helena Palma-Gudiel, Aldo Córdova-Palomera, Cristian Tornador, Carles Falcón, Núria Bargalló, Gustavo Deco, Lourdes Fañanás
Among the major psychiatric disorders, anxious-depressive disorders stand out as one of the more prevalent and more frequently associated with hypothalamic-pituitary-adrenal (HPA) axis abnormalities. Methylation at the exon 1F of the glucocorticoid receptor gene NR3C1 has been associated with both early stress exposure and risk for developing a psychiatric disorder; however, other NR3C1 promoter regions have been underexplored. Exon 1D emerges as a suggestive new target in stress-related disorders epigenetically sensitive to early adversity...
April 9, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29618598/routine-assessment-and-promotion-of-physical-activity-in-healthcare-settings-a-scientific-statement-from-the-american-heart-association
#11
REVIEW
Felipe Lobelo, Deborah Rohm Young, Robert Sallis, Michael D Garber, Sandra A Billinger, John Duperly, Adrian Hutber, Russell R Pate, Randal J Thomas, Michael E Widlansky, Michael V McConnell, Elizabeth A Joy
Physical inactivity is one of the most prevalent major health risk factors, with 8 in 10 US adults not meeting aerobic and muscle-strengthening guidelines, and is associated with a high burden of cardiovascular disease. Improving and maintaining recommended levels of physical activity leads to reductions in metabolic, hemodynamic, functional, body composition, and epigenetic risk factors for noncommunicable chronic diseases. Physical activity also has a significant role, in many cases comparable or superior to drug interventions, in the prevention and management of >40 conditions such as diabetes mellitus, cancer, cardiovascular disease, obesity, depression, Alzheimer disease, and arthritis...
May 1, 2018: Circulation
https://www.readbyqxmd.com/read/29606180/associations-of-prenatal-depressive-symptoms-with-dna-methylation-of-hpa-axis-related-genes-and-diurnal-cortisol-profiles-in-primary-school-aged-children
#12
Valeska Stonawski, Stefan Frey, Yulia Golub, Nicolas Rohleder, Jennifer Kriebel, Tamme W Goecke, Peter A Fasching, Matthias W Beckmann, Johannes Kornhuber, Oliver Kratz, Gunther H Moll, Hartmut Heinrich, Anna Eichler
Epigenetic DNA modifications in genes related to the hypothalamic-pituitary-adrenal (HPA) axis are discussed as a mechanism underlying the association between prenatal depression and altered child HPA activity. In a longitudinal study, DNA methylation changes related to prenatal depressive symptoms were investigated in 167 children aged 6 to 9 years. At six candidate genes, 126 cytosine-guanine dinucleotides were considered without correcting for multiple testing due to the exploratory nature of the study. Further associations with the basal child HPA activity were examined...
April 2, 2018: Development and Psychopathology
https://www.readbyqxmd.com/read/29600412/associations-of-monoamine-oxidase-a-gene-first-exon-methylation-with-sexual-abuse-and-current-depression-in-women
#13
David Checknita, Tomas J Ekström, Erika Comasco, Kent W Nilsson, Jari Tiihonen, Sheilagh Hodgins
Childhood physical abuse (PA) and sexual abuse (SA) interact with monoamine oxidase A (MAOA) gene polymorphism to modify risk for mental disorders. In addition, PA and SA may alter gene activity through epigenetic mechanisms such as DNA methylation, thereby further modifying risk for disorders. We investigated whether methylation in a region spanning the MAOA first exon and part of the first intron was associated with PA and/or SA, MAOA genotype, alcohol dependence, drug dependence, depression disorders, anxiety disorders, and conduct disorder...
March 29, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29595559/mthfr-gene-methylation-is-associated-with-perceived-stress-in-healthy-young-adults
#14
Karen M Jiménez, Angela J Pereira-Morales, Diego A Forero
BACKGROUND: Epigenetic factors have been identified in the past years as interesting candidates for psychiatric disorders and related endophenotypes. It has been found that the methylenetetrahydrofolate reductase (MTHFR) gene is associated with major depressive disorder, and the aim of the current study was to examine the possible association between perceived stress and MTHFR methylation, taking into account depressive symptoms as a covariate. PARTICIPANTS AND METHODS: Seventy-eight healthy Colombian participants (mean age=20...
June 2018: Psychiatric Genetics
https://www.readbyqxmd.com/read/29573791/understanding-the-molecular-mechanisms-underpinning-gene-by-environment-interactions-in-psychiatric-disorders-the-fkbp5-model
#15
REVIEW
Natalie Matosin, Thorhildur Halldorsdottir, Elisabeth B Binder
Epidemiologic and genetic studies suggest common environmental and genetic risk factors for a number of psychiatric disorders, including depression, bipolar disorder, and schizophrenia. Genetic and environmental factors, especially adverse life events, not only have main effects on disease development but also may interact to shape risk and resilience. Such gene by adversity interactions have been described for FKBP5, an endogenous regulator of the stress-neuroendocrine system, conferring risk for a number of psychiatric disorders...
March 21, 2018: Biological Psychiatry
https://www.readbyqxmd.com/read/29543532/crh-crhr1-mediates-prenatal-synthetic-glucocorticoid-programming-of-depression-like-behavior-across-2-generations
#16
Yong-Jun Xu, Hui Sheng, Tian-Wen Wu, Qing-Yue Bao, You Zheng, Yan-Min Zhang, Yu-Xiang Gong, Jian-Qiang Lu, Zhen-Dong You, Yang Xia, Xin Ni
Pregnant women at risk of preterm labor usually receive synthetic glucocorticoids (sGCs) to promote fetal lung development. Emerging evidence indicates that antenatal sGC increases the risk of affective disorders in offspring. Data from animal studies show that such disorders can be transmitted to the second generation. However, the molecular mechanisms underlying the intergenerational effects of prenatal sGC remain largely unknown. Here we show that prenatal dexamethasone (Dex) administration in late pregnancy induced depression-like behavior in first-generation (F1) offspring, which could be transmitted to second-generation (F2) offspring with maternal dependence...
March 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29540737/g-protein-coupled-receptor-gpr17-regulates-oligodendrocyte-differentiation-in-response-to-lysolecithin-induced-demyelination
#17
Changqing Lu, Lihua Dong, Hui Zhou, Qianmei Li, Guojiao Huang, Shu Jun Bai, Linchuan Liao
Oligodendrocytes are the myelin-producing cells of the central nervous system (CNS). A variety of brain disorders from "classical" demyelinating diseases, such as multiple sclerosis, stroke, schizophrenia, depression, Down syndrome and autism, are shown myelination defects. Oligodendrocyte myelination is regulated by a complex interplay of intrinsic, epigenetic and extrinsic factors. Gpr17 (G protein-coupled receptor 17) is a G protein-coupled receptor, and has been identified to be a regulator for oligodendrocyte development...
March 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29520039/transgenerational-epigenetic-influences-of-paternal-environmental-exposures-on-brain-function-and-predisposition-to-psychiatric-disorders
#18
REVIEW
Shlomo Yeshurun, Anthony J Hannan
In recent years, striking new evidence has demonstrated non-genetic inheritance of acquired traits associated with parental environmental exposures. In particular, this transgenerational modulation of phenotypic traits is of direct relevance to psychiatric disorders, including depression, post-traumatic stress disorder, and other anxiety disorders. Here we review the recent progress in this field, with an emphasis on acquired traits of psychiatric illnesses transmitted epigenetically via the male lineage. We discuss the transgenerational effects of paternal exposure to stress vs...
March 8, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29513516/prairie-voles-as-a-model-for-understanding-the-genetic-and-epigenetic-regulation-of-attachment-behaviors
#19
Julie M Sadino, Zoe R Donaldson
Over a lifetime, humans build relationships with family, friends, and partners that are critically important for our mental and physical health. Unlike commonly used laboratory mice and rats, Microtine rodents provide a unique model to study the neurobiology underlying pair bonding and the selective attachments that form between adults. Comparisons between monogamous prairie voles and the closely related but nonmonogamous meadow and montane voles have revealed that brain-region-specific neuropeptide receptor patterning modulates social behavior between and within species...
April 6, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29513367/the-familial-aggregation-of-atopic-diseases-and-depression-or-anxiety-in-children
#20
B K Brew, C Lundholm, T Gong, H Larsson, C Almqvist
BACKGROUND: Children with asthma and atopic diseases have an increased risk of depression or anxiety. Each of these diseases has strong genetic and environmental components; therefore, it seems likely that there is a shared liability rather than causative risk. OBJECTIVE: To investigate the existence and nature of familial aggregation for the comorbidity of atopic diseases and depression or anxiety. METHODS: Participants came from the Childhood and Adolescent Twin Study in Sweden (CATSS), n = 14 197...
March 7, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
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