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epigenetics and depression

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https://www.readbyqxmd.com/read/28916331/depressive-like-phenotype-induced-by-prenatal-dexamethasone-in-mice-is-reversed-by-desipramine
#1
Mirko Conti, Stefan Spulber, Marilena Raciti, Sandra Ceccatelli
Exposure to prenatal insults has been associated with an increased risk for neuropsychiatric disorders, including depression, but the mechanisms are still poorly understood. Persistent alterations of the HPA axis feedback mechanism as well as adult impaired neurogenesis are believed to play a relevant role in the etiology of depression. In addition, growing evidence points at epigenetic reprogramming as a key factor. We have previously shown that prenatal exposure to the synthetic glucocorticoid dexamethasone (DEX) impairs neurogenesis and leads to late onset of depression-like behavior that does not respond to the SSRI antidepressant fluoxetine (FLX)...
September 12, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28894112/perinatal-malnutrition-leads-to-sexually-dimorphic-behavioral-responses-with-associated-epigenetic-changes-in-the-mouse-brain
#2
Daniel Nätt, Riccardo Barchiesi, Josef Murad, Jian Feng, Eric J Nestler, Frances A Champagne, Annika Thorsell
Childhood malnutrition is a risk factor for mental disorders, such as major depression and anxiety. Evidence shows that similar early life adversities induce sex-dependent epigenetic reprogramming. However, little is known about how genes are specifically affected by early malnutrition and the implications for males and females respectively. One relevant target is neuropeptide Y (NPY), which regulates both stress and food-intake. We studied maternal low protein diet (LPD) during pregnancy/lactation in mice...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28890420/perinatal-inflammation-and-adult-psychopathology-from-preclinical-models-to-humans
#3
REVIEW
Amaicha Mara Depino
Perinatal environment plays a crucial role in brain development and determines its function through life. Epidemiological studies and clinical reports link perinatal exposure to infection and/or immune activation to various psychiatric disorders. In addition, accumulating evidence from animal models shows that perinatal inflammation can affect various behaviors relevant to psychiatric disorders such as schizophrenia, autism, anxiety and depression. Remarkably, the effects on behavior and brain function do not always depend on the type of inflammatory stimulus or the perinatal age targeted, so diverse inflammatory events can have similar consequences on the brain...
September 7, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28887651/a-cell-culture-model-for-investigation-of-synapse-influenceability-epigenetics-expression-and-function-of-gene-targets-important-for-synapse-formation-and-preservation-in-sh-sy5y-neuroblastoma-cells-differentiated-by-retinoic-acid
#4
Kirsten Jahn, C Wieltsch, N Blumer, M Mehlich, H Pathak, A Q Khan, H Hildebrandt, H Frieling
SH-SY5Y neuroblastoma cells are frequently used for different neuronal cell culture models. As there is no "gold-standard", miscellaneous protocols exist to differentiate these cells into a neuronal cell type. Here, the aim was to find a differentiation condition making cells suitable for investigation of influenceability of synapses by environmental conditions in pharmacologic experiments. For this purpose, effects on synapse molecules should be somehow rateable and cells should be usable for functional analysis like calcium imaging...
September 8, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28886759/epigenetic-regulation-of-the-kappa-opioid-receptor-by-child-abuse
#5
Pierre-Eric Lutz, Jeffrey A Gross, Sabine K Dhir, Gilles Maussion, Jennie Yang, Alexandre Bramoulle, Michael J Meaney, Gustavo Turecki
BACKGROUND: Experiences of abuse and neglect during childhood are major predictors of the emergence of depressive and suicidal behaviors throughout life. The underlying biological mechanisms, however, remain poorly understood. Here, we focused on the opioid system as a potential brain substrate mediating these effects. METHODS: Postmortem samples from three brain structures regulating social bonds and emotions were analyzed. Groups were constituted of depressed individuals who died by suicide, with or without a history of severe child abuse, and of psychiatrically healthy control subjects...
July 27, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28886448/exploring-hepsin-functional-genetic-variation-association-with-disease-specific-protein-expression-in-bipolar-disorder-applications-of-a-proteomic-informed-genomic-approach
#6
Malik Nassan, Yun-Fang Jia, Greg Jenkins, Colin Colby, Scott Feeder, Doo-Sup Choi, Marin Veldic, Susan L McElroy, David J Bond, Richard Weinshilboum, Joanna M Biernacka, Mark A Frye
In a prior discovery study, increased levels of serum Growth Differentiation Factor 15 (GDF15), Hepsin (HPN), and Matrix Metalloproteinase-7 (MMP7) were observed in bipolar depressed patients vs controls. This exploratory post-hoc analysis applied a proteomic-informed genomic research strategy to study the potential functional role of these proteins in bipolar disorder (BP). Utilizing the Genotype-Tissue Expression (GTEx) database to identify cis-acting blood expression quantitative trait loci (cis-eQTLs), five eQTL variants from the HPN gene were analyzed for association with BP cases using genotype data of cases from the discovery study (n = 58) versus healthy controls (n = 777)...
July 4, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28877103/abnormal-modification-of-histone-acetylation-involved-in-depression-like-behaviors-of-rats-induced-by-chronically-unpredicted-stress
#7
Hai-Yan Li, Qing-Song Jiang, Xiao-Yan Fu, Xin-Hui Jiang, Qi-Xin Zhou, Hong-Mei Qiu
Depression is a complex multifactorial mental disorder. Its etiology involves many factors such as social environments, genetics, and psychology. Recent studies have shown that epigenetic modification may be associated with depression. Histone acetylation is one of the main mechanisms of epigenetic modification and plays an important role in genetic expression. In this study, we investigated the role of histone acetylation in the depression-like behaviors of rats undergoing chronically unpredicted stress (CUS) by detecting the mRNA and protein expression of histone deacetylase 5, cAMP-response element-binding protein, and the level of histone acetylated modification of H3K14, H3K23, and H4K16 in the prefrontal cortex and hippocampus of the rats...
September 4, 2017: Neuroreport
https://www.readbyqxmd.com/read/28874920/the-manual-stimulation-of-acupuncture-points-in-the-treatment-of-post-traumatic-stress-disorder-a-review-of-clinical-emotional-freedom-techniques
#8
Dawson Church, David Feinstein
Background: The manual stimulation of acupuncture points has been combined with components of cognitive and exposure therapies into a clinical and self-help approach known as Emotional Freedom Techniques (EFT). More than 40 clinical trials and four meta-analytic reviews of EFT treatments have demonstrated large effect sizes with a range of conditions, including pain, PTSD (in both civilian and military veteran populations), phobias, anxiety, and depression. Objective: This review describes the approach, with a focus on PTSD in veterans and service members, provides an overview of how EFT is most commonly applied, and outlines obstacles and cautions related to its implementation...
August 1, 2017: Medical Acupuncture
https://www.readbyqxmd.com/read/28867654/preterm-behavioral-epigenetics-a-systematic-review
#9
REVIEW
Livio Provenzi, Elena Guida, Rosario Montirosso
Behavioral epigenetics is revealing new pathways that lead individuals from early adversity exposures to later-in-life detrimental outcomes. Preterm birth constitutes one of the major adverse events in human development. Preterm infants are hospitalized in the Neonatal Intensive Care Unit (NICU) where they are exposed to life-saving yet pain-inducing procedures and to protective care. The application of behavioral epigenetics to the field of preterm studies (i.e., Preterm Behavioral Epigenetics, PBE) is rapidly growing and holds promises to provide valid insights for research and clinical activity...
September 1, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28777307/epigenomics-of-major-depressive-disorders-and-schizophrenia-early-life-decides
#10
REVIEW
Anke Hoffmann, Vincenza Sportelli, Michael Ziller, Dietmar Spengler
Brain development is guided by the interactions between the genetic blueprint and the environment. Epigenetic mechanisms, especially DNA methylation, can mediate these interactions and may also trigger long-lasting adaptations in developmental programs that increase the risk of major depressive disorders (MDD) and schizophrenia (SCZ). Early life adversity is a major risk factor for MDD/SCZ and can trigger persistent genome-wide changes in DNA methylation at genes important to early, but also to mature, brain function, including neural proliferation, differentiation, and synaptic plasticity, among others...
August 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28754344/the-effect-of-childhood-trauma-on-serum-bdnf-in-bipolar-depression-is-modulated-by-the-serotonin-promoter-genotype
#11
Francesco Benedetti, Oliver Ambrée, Clara Locatelli, Cristina Lorenzi, Sara Poletti, Cristina Colombo, Volker Arolt
In healthy humans, both childhood trauma and the short form of the serotonin promoter transporter genotype (5-HTTLPR) are associated with lower levels of brain-derived neurotrophic factor (BDNF). In subjects with bipolar disorder (BD), lower levels of BDNF and a higher degree of childhood trauma were observed compared with healthy controls. However, is still unknown if the functional 5-HTTLPR polymorphisms exerts an effect on both abnormalities. In 40 inpatients affected by a major depressive episode in the course of BD, we genotyped 5-HTTLPR, measured serum BDNF with ELISA, and assessed early adversities by the childhood trauma questionnaire (CTQ)...
July 25, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28750583/association-of-a-history-of-child-abuse-with-impaired-myelination-in-the-anterior-cingulate-cortex-convergent-epigenetic-transcriptional-and-morphological-evidence
#12
Pierre-Eric Lutz, Arnaud Tanti, Alicja Gasecka, Sarah Barnett-Burns, John J Kim, Yi Zhou, Gang G Chen, Marina Wakid, Meghan Shaw, Daniel Almeida, Marc-Aurele Chay, Jennie Yang, Vanessa Larivière, Marie-Noël M'Boutchou, Léon C van Kempen, Volodymyr Yerko, Josée Prud'homme, Maria Antonietta Davoli, Kathryn Vaillancourt, Jean-François Théroux, Alexandre Bramoullé, Tie-Yuan Zhang, Michael J Meaney, Carl Ernst, Daniel Côté, Naguib Mechawar, Gustavo Turecki
OBJECTIVE: Child abuse has devastating and long-lasting consequences, considerably increasing the lifetime risk of negative mental health outcomes such as depression and suicide. Yet the neurobiological processes underlying this heightened vulnerability remain poorly understood. The authors investigated the hypothesis that epigenetic, transcriptomic, and cellular adaptations may occur in the anterior cingulate cortex as a function of child abuse. METHOD: Postmortem brain samples from human subjects (N=78) and from a rodent model of the impact of early-life environment (N=24) were analyzed...
July 28, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28738770/effects-of-resveratrol-and-other-polyphenols-on-the-most-common-brain-age-related-diseases
#13
Fiorella Sarubbo, David Moranta, Victor Jose Asensio, Antonio Miralles, Susana Esteban
With the global increase in the elderly population, modern societies must meet the challenge to find strategies to reduce the consequences of aging process; thereby decreasing the incidence of age-related neurodegenerative diseases. Over the last two decades, oxidative stress and recently inflammation, have been pointed out as the leading causes of brain aging. As a suggested treatment, the consumption or administration of antioxidant and anti-inflammatory molecules, such as polyphenols, present in food, is recommended as a beneficial strategy for preventing brain aging and several brain age-related diseases...
July 24, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28723643/methyltransferase-g9a-promotes-cervical-cancer-angiogenesis-and-decreases-patient-survival
#14
Ruey-Jien Chen, Chia-Tung Shun, Men-Luh Yen, Chia-Hung Chou, Ming-Chieh Lin
Research suggests that the epigenetic regulator G9a, a H3K9 histone methyltransferase, is involved in cancer invasion and metastasis. Here we show that G9a is linked to cancer angiogenesis and poor patient survival. Invasive cervical cancer has a higher G9a expression than cancer precursors or normal epithelium. Pharmacological inhibition and genetic silencing of G9a suppresses H3K9 methylation, cancer cell proliferation, angiogenesis, and cancer cell invasion/migration, but not apoptosis. Microarray and quantitative reverse transcription polymerase chain reaction analyses reveal that G9a induces a cohort of angiogenic factors that include angiogenin, interleukin-8, and C-X-C motif chemokine ligand 16...
July 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28714605/epigenetic-alterations-and-prenatal-maternal-depression
#15
REVIEW
Zsofia Nemoda, Moshe Szyf
Major depressive disorder of the mother affects 6 to 17% of pregnancies worldwide and can lead to negative outcomes, such as preterm delivery and later mental health problems of the child. It has been proposed that developmental programming has long-lasting effects in the offspring that might be mediated by epigenetic mechanisms, such as DNA methylation. Altered stress regulation or impaired immunological function of the mother can potentially affect DNA methylation processes of the fetus, changing gene expression levels in utero...
July 17, 2017: Birth defects research
https://www.readbyqxmd.com/read/28712426/negative-affect-is-unrelated-to-fluctuations-in-hormone-levels-across-the-menstrual-cycle-evidence-from-a-multisite-observational-study-across-two-successive-cycles
#16
Michael P Hengartner, Tillmann H C Kruger, Kirsten Geraedts, Enrico Tronci, Toni Mancini, Fabian Ille, Marcel Egli, Susanna Röblitz, Rainald Ehrig, Lanja Saleh, Katharina Spanaus, Cordula Schippert, Yuanyuan Zhang, Brigitte Leeners
BACKGROUND: Female sex hormones may play a crucial role in the occurrence of cycle-related mood disorders. However, the literature is inconsistent and methodologically stringent observational studies on the relationship between sex hormones and negative affect are lacking. METHODS: In this longitudinal multisite study from Hannover, Germany, and Zurich, Switzerland, we examined oestrogen, progesterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone serum levels in association with negative affect as measured with the Positive and Negative Affect Schedule (PANAS)...
August 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28698163/selective-effect-of-hydroxyapatite-nanoparticles-on-osteoporotic-and-healthy-bone-formation-correlates-with-intracellular-calcium-homeostasis-regulation
#17
Rui Zhao, Pengfei Xie, Kun Zhang, Zhurong Tang, Xuening Chen, Xiangdong Zhu, Yujiang Fan, Xiao Yang, Xingdong Zhang
Adequate bone substitutes osseointegration has been difficult to achieve in osteoporosis. Hydroxyapatite of the osteoporotic bone, secreted by pathologic osteoblasts, had a smaller crystal size and lower crystallinity than that of the normal. To date, little is known regarding the interaction of synthetic hydroxyapatite nanoparticles (HANPs) with osteoblasts born in bone rarefaction. The present study investigated the biological effects of HANPs on osteoblastic cells derived from osteoporotic rat bone (OVX-OB), in comparison with the healthy ones (SHM-OB)...
September 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28691768/microbiome-inflammation-epigenetic-alterations-and-mental-diseases
#18
REVIEW
Reza Alam, Hamid M Abdolmaleky, Jin-Rong Zhou
Major mental diseases such as autism, bipolar disorder, schizophrenia, and major depressive disorder are debilitating illnesses with complex etiologies. Recent findings show that the onset and development of these illnesses cannot be well described by the one-gene; one-disease approach. Instead, their clinical presentation is thought to result from the regulative interplay of a large number of genes. Even though the involvement of many genes are likely, up regulating and activation or down regulation and silencing of these genes by the environmental factors play a crucial role in contributing to their pathogenesis...
July 10, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28667793/physiological-mechanisms-through-which-heat-stress-compromises-reproduction-in-pigs
#19
REVIEW
Jason W Ross, Benjamin J Hale, Jacob T Seibert, Matthew R Romoser, Malavika K Adur, Aileen F Keating, Lance H Baumgard
Seasonal variations in environmental temperatures impose added stress on domestic species bred for economically important production traits. These heat-mediated stressors vary on a seasonal, daily, or spatial scale, and negatively impact behavior and reduce feed intake and growth rate, which inevitably lead to reduced herd productivity. The seasonal infertility observed in domestic swine is primarily characterized by depressed reproductive performance, which manifests as delayed puberty onset, reduced farrowing rates, and extended weaning-to-estrus intervals...
July 1, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28662189/affective-and-cognitive-behavior-in-the-alpha-galactosidase-a-deficient-mouse-model-of-fabry-disease
#20
Lukas Hofmann, Franziska Karl, Claudia Sommer, Nurcan Üçeyler
Fabry disease is an X-linked inherited lysosomal storage disorder with intracellular accumulation of globotriaosylceramide (Gb3) due to α-galactosidase A (α-Gal A) deficiency. Fabry patients frequently report of anxiety, depression, and impaired cognitive function. We characterized affective and cognitive phenotype of male mice with α-Gal A deficiency (Fabry KO) and compared results with those of age-matched male wildtype (WT) littermates. Young (3 months) and old (≥ 18 months) mice were tested in the naïve state and after i...
2017: PloS One
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