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malaria vaccine 2015

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https://www.readbyqxmd.com/read/28774810/preparedness-of-adolescents-departing-from-athens-international-airport-to-africa-or-asia-a-five-year-airport-based-prospective-study
#1
Helena C Maltezou, Androula Pavli, Kalliopi Theodoridou, Eleftherios Bournousouzis, Athanasios Minitsios, Panos Katerelos, Ioanna Lymperi, Maria Theodoridou
BACKGROUND: The number of adolescents who travel has increased. We estimated the preparedness of adolescents (12-18 years) departing from Athens to Africa and Asia. METHODS: An airport-based survey was conducted from 2011 to 2015. RESULTS: Sixty-eight adolescents participated; 27/68 (40%) had the Greek nationality. Their main destinations were the Indian subcontinent (37%) and South-East Asia (32%). Most adolescents planned to stay for <1 month (69%) or for 1-3 months (22%)...
August 1, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/28770814/malaria
#2
REVIEW
Margaret A Phillips, Jeremy N Burrows, Christine Manyando, Rob Hooft van Huijsduijnen, Wesley C Van Voorhis, Timothy N C Wells
Malaria is caused in humans by five species of single-celled eukaryotic Plasmodium parasites (mainly Plasmodium falciparum and Plasmodium vivax) that are transmitted by the bite of Anopheles spp. mosquitoes. Malaria remains one of the most serious infectious diseases; it threatens nearly half of the world's population and led to hundreds of thousands of deaths in 2015, predominantly among children in Africa. Malaria is managed through a combination of vector control approaches (such as insecticide spraying and the use of insecticide-treated bed nets) and drugs for both treatment and prevention...
August 3, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28619415/international-travelers-sociodemographic-health-and-travel-characteristics-an-italian-study
#3
Gianmarco Troiano, Astrid Mercone, Alessandra Bagnoli, Nicola Nante
BACKGROUND: Approximately the 8% of travelers requires medical care, with the diagnosis of a vaccine-preventable disease. The aim of our study was to analyze the socio-demographic, health and travel characteristics of the Italian international travelers. METHODS: We conducted a cross sectional study from January 2015 to June 2016, at the Travel Medicine Clinic of Siena, asking the doctor to interview patients who attended the Clinic, recording socio-demographic and travel information, malaria prophylaxis, vaccinations...
March 2017: Annals of Global Health
https://www.readbyqxmd.com/read/28619230/innovative-financing-instruments-for-global-health-2002-15-a-systematic-analysis
#4
Rifat Atun, Sachin Silva, Felicia M Knaul
Development assistance for health (DAH), the value of which peaked in 2013 and fell in 2015, is unlikely to rise substantially in the near future, increasing reliance on domestic and innovative financing sources to sustain health programmes in low-income and middle-income countries. We examined innovative financing instruments (IFIs)-financing schemes that generate and mobilise funds-to estimate the quantum of financing mobilised from 2002 to 2015. We identified ten IFIs, which mobilised US$8·9 billion (2·3% of overall DAH) in 2002-15...
July 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28560654/newer-vaccines-against-mosquito-borne-diseases
#5
Anju Aggarwal, Neha Garg
Mosquitos are responsible for a number of protozoal and viral diseases. Malaria, dengue, Japanese encephalitis (JE) and chikungunya epidemics occur commonly all over the world, leading to marked mortality and morbidity in children. Zika, Yellow fever and West Nile fever are others requiring prevention. Environmental control and mosquito bite prevention are useful in decreasing the burden of disease but vaccination has been found to be most cost-effective and is the need of the hour. RTS,S/AS01 vaccine is the first malaria vaccine being licensed for use against P...
May 31, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28483199/a-prime-boost-immunization-regimen-based-on-a-simian-adenovirus-36-vectored-multi-stage-malaria-vaccine-induces-protective-immunity-in-mice
#6
Jairo A Fonseca, Jessica N McCaffery, Elena Kashentseva, Balwan Singh, Igor P Dmitriev, David T Curiel, Alberto Moreno
Malaria remains a considerable burden on public health. In 2015, the WHO estimates there were 212 million malaria cases causing nearly 429,000 deaths globally. A highly effective malaria vaccine is needed to reduce the burden of this disease. We have developed an experimental vaccine candidate (PyCMP) based on pre-erythrocytic (CSP) and erythrocytic (MSP1) stage antigens derived from the rodent malaria parasite P. yoelii. Our protein-based vaccine construct induces protective antibodies and CD4(+) T cell responses...
May 31, 2017: Vaccine
https://www.readbyqxmd.com/read/28385607/malaria-vaccine-who-position-paper-january-2016-recommendations
#7
(no author information available yet)
This article presents the World Health Organization's (WHO) recommendations on the use of malaria vaccine excerpted from the WHO position paper on malaria vaccine published in the Weekly epidemiological Record in January 2016 [1]. The current document is the first WHO position paper on malaria vaccination and focuses primarily on the available evidence concerning the only malaria vaccine having received a positive regulation assessment from the European Medicines Agency (EMA) [2]. The position paper gives consideration to the epidemiological features of the disease and assesses the potential use of the vaccine for public health benefits...
April 3, 2017: Vaccine
https://www.readbyqxmd.com/read/28358796/yellow-fever-outbreak-kongo-central-province-democratic-republic-of-the-congo-august-2016
#8
John O Otshudiema, Nestor G Ndakala, Elande-Taty K Mawanda, Gaston P Tshapenda, Jacques M Kimfuta, Loupy-Régence N Nsibu, Abdou S Gueye, Jacob Dee, Rossanne M Philen, Coralie Giese, Christopher S Murrill, Ray R Arthur, Benoit I Kebela
On April 23, 2016, the Democratic Republic of the Congo's (DRC's) Ministry of Health declared a yellow fever outbreak. As of May 24, 2016, approximately 90% of suspected yellow fever cases (n = 459) and deaths (45) were reported in a single province, Kongo Central Province, that borders Angola, where a large yellow fever outbreak had begun in December 2015. Two yellow fever mass vaccination campaigns were conducted in Kongo Central Province during May 25-June 7, 2016 and August 17-28, 2016. In June 2016, the DRC Ministry of Health requested assistance from CDC to control the outbreak...
March 31, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28301539/identifying-inequities-in-maternal-and-child-health-through-risk-stratification-to-inform-health-systems-strengthening-in-northern-togo
#9
Katharine J McCarthy, Sandra Braganza, Kevin Fiori, Christophe Gbeleou, Vivien Kpakpo, Andrew Lopez, Jennifer Schechter, Alicia Singham Goodwin, Heidi E Jones
OBJECTIVE: In Togo, substantial progress in maternal and child health is needed to reach global development goals. To better inform clinic and community-based health services, this study identifies factors associated with maternal and child health care utilization in the Kara region of Northern Togo. METHODS: We conducted a population-representative household survey of four health clinic catchment areas of 1,075 women of reproductive age in 2015. Multivariable logistic regression was used to model individual and structural factors associated with utilization of four maternal and child health services...
2017: PloS One
https://www.readbyqxmd.com/read/28283009/-production-and-molecular-characterization-of-plasmodium-falciparum-recombinant-circumsporozoite-protein-with-37-nanp-and-4-nvdp-epitopes
#10
Yunus Uyar, Abdüssamed Akşit, Serkan Karaca, Şirin Sahra Ceylan, Merve Yürük
Malaria is caused by the protozoan parasite Plasmodium, the leading cause of death amongst the parasitic diseases. The disease is transmitted to human by the bites of female Anopheles mosquitoes. According to the World Health Organization (WHO) data, there were an estimated 214 million malaria cases and estimated 438.000 deaths occurred worldwide, in 2015. It is observed that 90% of all the deaths due to malaria occur in Africa. 78% of these cases were children who are under five years old. Intensive malaria interventions helped to reduce malaria incidence by 37% between 2000 and 2015...
January 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28271746/future-proofing-global-health-governance-of-priorities
#11
Belinda Bennett, I Glenn Cohen, Sara E Davies, Lawrence O Gostin, Peter S Hill, Aditi Mankad, Alexandra L Phelan
The year 2015 was a significant anniversary for global health: 15 years since the adoption of the Millennium Development Goals and the creation of the Global Alliance for Vaccines and Immunization, followed two years later by the Global Fund to Fight AIDS, TB and Malaria. 2015 was also the 10-year anniversary of the adoption of the International Health Regulations (May 2005) and the formal entering into force of the Framework Convention on the Tobacco Control (February 2005). The anniversary of these frameworks and institutions illustrates the growth and contribution of 'global' health diplomacy...
March 8, 2017: Global Public Health
https://www.readbyqxmd.com/read/28262332/report-from-the-world-health-organization-s-third-product-development-for-vaccines-advisory-committee-pdvac-meeting-geneva-8-10th-june-2016
#12
Birgitte K Giersing, Johan Vekemans, Samantha Nava, David C Kaslow, Vasee Moorthy
The third meeting of WHO's Product Development for Vaccines Advisory Committee (PDVAC) was held in June 2016, with a remit to revisit the pathogen areas for which significant progress has occurred since recommendations from the 2015 meeting, as well as to consider new advances in the development of vaccines against other pathogens. Since the previous meeting, significant progress has been made with regulatory approvals of the first malaria and dengue vaccines, and the first phase III trials of a respiratory syncytial virus (RSV) vaccine candidate has started in the elderly and pregnant women...
March 2, 2017: Vaccine
https://www.readbyqxmd.com/read/28164028/the-clinical-spectrum-of-severe-acute-malnutrition-in-children-in-cameroon-a-hospital-based-study-in-yaounde-cameroon
#13
Andreas Chiabi, Berthe Malangue, Seraphin Nguefack, Félicitée Nguefack Dongmo, Florence Fru, Virginie Takou, Fru Angwafo
BACKGROUND: Severe acute malnutrition (SAM) is a major health problem, and the cause of more than half of childhood deaths in children less than 5 years in developing countries. Globally, 20 million children under 5 years of age are severely malnourished according to the World Health Organization (WHO). In Cameroon, the prevalence of SAM remains high and estimated at 1.9% in 2011 and 1.3% in 2014. The aim of this study was to determine the epidemiology, clinical aspects and outcome of SAM at the Yaounde Gynaeco-Obstetric and Pediatric Hospital (YGOPH)...
January 2017: Translational pediatrics
https://www.readbyqxmd.com/read/28017399/safety-and-immunogenicity-of-a-recombinant-adenovirus-type-5-vector-based-ebola-vaccine-in-healthy-adults-in-sierra-leone-a-single-centre-randomised-double-blind-placebo-controlled-phase-2-trial
#14
Feng-Cai Zhu, Alie H Wurie, Li-Hua Hou, Qi Liang, Yu-Hua Li, James B W Russell, Shi-Po Wu, Jing-Xin Li, Yue-Mei Hu, Qiang Guo, Wen-Bo Xu, Abdul R Wurie, Wen-Juan Wang, Zhe Zhang, Wen-Jiao Yin, Manal Ghazzawi, Xu Zhang, Lei Duan, Jun-Zhi Wang, Wei Chen
BACKGROUND: A recombinant adenovirus type-5 vector-based vaccine expressing the glycoprotein of Ebola Zaire Makona variant showed good safety and immunogenicity in a phase 1 trial of healthy Chinese adults. We aimed to assess the safety and immunogenicity of this vaccine in healthy adults in Sierra Leone and to determine the optimal dose. METHODS: We did a single-centre, randomised, double-blind, placebo-controlled, phase 2 clinical trial at Sierra Leone-China Friendship Hospital, Freetown, Sierra Leone...
February 11, 2017: Lancet
https://www.readbyqxmd.com/read/27892847/international-adoption-from-ethiopia-an-overview-of-the-health-status-at-arrival-in-belgium
#15
Lydia Van Kesteren, Marek Wojciechowski
BACKGROUND: Ethiopia is a densely populated country with a fast growing economy. Still socioeconomic and health issues render many children parentless. One thousand and twenty eight Ethiopian children have been adopted in Belgium from September 2005 to September 2015. Little has been published about their health status at arrival. METHODS: Three hundred and fifteen children adopted from Ethiopia were clinically evaluated at the Institute of Tropical Medicine in Antwerp from 1 January 2008 until 31 December 2014...
November 28, 2016: Acta Clinica Belgica
https://www.readbyqxmd.com/read/27855488/an-expanding-toolkit-for-preclinical-pre-erythrocytic-malaria-vaccine-development-bridging-traditional-mouse-malaria-models-and-human-trials
#16
REVIEW
Ryan Wj Steel, Stefan Hi Kappe, Brandon K Sack
Malaria remains a significant public health burden with 214 million new infections and over 400,000 deaths in 2015. Elucidating relevant Plasmodium parasite biology can lead to the identification of novel ways to control and ultimately eliminate the parasite within geographic areas. Particularly, the development of an effective vaccine that targets the clinically silent pre-erythrocytic stages of infection would significantly augment existing malaria elimination tools by preventing both the onset of blood-stage infection/disease as well as spread of the parasite through mosquito transmission...
December 2016: Future Microbiology
https://www.readbyqxmd.com/read/27818362/impact-of-infectious-disease-epidemics-on-tuberculosis-diagnostic-management-and-prevention-services-experiences-and-lessons-from-the-2014-2015-ebola-virus-disease-outbreak-in-west-africa
#17
Rashid Ansumana, Samuel Keitell, Gregory M T Roberts, Francine Ntoumi, Eskild Petersen, Giuseppe Ippolito, Alimuddin Zumla
The World Health Organization (WHO) Global Tuberculosis Report 2015 states that 28% of the world's 9.6 million new tuberculosis (TB) cases are in the WHO Africa Region. The Mano River Union (MRU) countries of West Africa-Guinea, Sierra Leone, and Liberia-have made incremental sustained investments into TB control programmes over the past two decades. The devastating Ebola virus disease (EVD) outbreak of 2014-2015 in West Africa impacted significantly on all sectors of the healthcare systems in the MRU countries, including the TB prevention and control programmes...
November 3, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27394698/interventions-for-improving-coverage-of-childhood-immunisation-in-low-and-middle-income-countries
#18
REVIEW
Angela Oyo-Ita, Charles S Wiysonge, Chioma Oringanje, Chukwuemeka E Nwachukwu, Olabisi Oduwole, Martin M Meremikwu
BACKGROUND: Immunisation is a powerful public health strategy for improving child survival, not only by directly combating key diseases that kill children but also by providing a platform for other health services. However, each year millions of children worldwide, mostly from low- and middle-income countries (LMICs), do not receive the full series of vaccines on their national routine immunisation schedule. This is an update of the Cochrane review published in 2011 and focuses on interventions for improving childhood immunisation coverage in LMICs...
July 10, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27391270/expression-and-evaluation-of-recombinant-plasmodium-knowlesi-merozoite-surface-protein-3-msp-3-for-detection-of-human-malaria
#19
Jeremy Ryan De Silva, Yee-Ling Lau, Mun-Yik Fong
Malaria remains a major health threat in many parts of the globe and causes high mortality and morbidity with 214 million cases of malaria occurring globally in 2015. Recent studies have outlined potential diagnostic markers and vaccine candidates one of which is the merozoite surface protein (MSP)-3. In this study, novel recombinant Plasmodium knowlesi MSP-3 was cloned, expressed and purified in an Escherichia coli system. Subsequently, the recombinant protein was evaluated for its sensitivity and specificity...
2016: PloS One
https://www.readbyqxmd.com/read/27355540/implementation-of-rts-s-as01-malaria-vaccine-the-need-for-further-evidence
#20
EDITORIAL
John Clemens, Vasee Moorthy
No abstract text is available yet for this article.
June 30, 2016: New England Journal of Medicine
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