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https://www.readbyqxmd.com/read/28735755/protective-effects-of-acute-exercise-prior-to-doxorubicin-on-cardiac-function-of-breast-cancer-patients-a-proof-of-concept-rct
#1
A A Kirkham, R E Shave, K A Bland, J M Bovard, N D Eves, K A Gelmon, D C McKenzie, S A Virani, E J Stöhr, D E R Warburton, K L Campbell
BACKGROUND: Preclinical studies have reported that a single treadmill session performed 24h prior to doxorubicin provides cardio-protection. We aimed to characterize the acute change in cardiac function following an initial doxorubicin treatment in humans and determine whether an exercise session performed 24h prior to treatment changes this response. METHODS: Breast cancer patients were randomized to either 30min of vigorous-intensity exercise 24h prior to the first doxorubicin treatment (n=13), or no vigorous exercise for 72h prior to treatment (control, n=11)...
July 14, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28733187/a-confidence-building-exercise-in-data-and-identifiability-modeling-cancer-chemotherapy-as-a-case-study
#2
Marisa C Eisenberg, Harsh V Jain
Mathematical modeling has a long history in the field of cancer therapeutics, and there is increasing recognition that it can help uncover the mechanisms that underlie tumor response to treatment. However, making quantitative predictions with such models often requires parameter estimation from data, raising questions of parameter identifiability and estimability. Even in the case of structural (theoretical) identifiability, imperfect data and the resulting practical unidentifiability of model parameters can make it difficult to infer the desired information, and in some cases, to yield biologically correct inferences and predictions...
July 18, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28733130/a-pilot-randomized-controlled-trial-on-the-effects-of-a-progressive-exercise-program-on-the-range-of-motion-and-upper-extremity-grip-strength-in-young-adults-with-breast-cancer
#3
Marize Ibrahim, Thierry Muanza, Nadia Smirnow, Warren Sateren, Beatrice Fournier, Petr Kavan, Michael Palumbo, Richard Dalfen, Mary-Ann Dalzell
BACKGROUND: The diagnosis of breast cancer in young women (aged 18-45 years) has been increasing. Women are commonly left coping with treatment-related disabilities of the upper limb that can persist for > 2 years postoperatively. PATIENTS AND METHODS: A total of 59 young breast cancer patients (29 in the intervention group and 30 in the control group) participated in a pilot prospective randomized controlled trial to determine whether a 12-week postradiation exercise program would improve long-term arm mobility, pain, and handgrip strength...
June 24, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28731882/the-effect-on-bone-outcomes-of-home-based-exercise-intervention-for-prostate-cancer-survivors-receiving-androgen-deprivation-therapy-a-pilot-randomized-controlled-trial
#4
Soo Hyun Kim, Do Hwan Seong, Sang Min Yoon, Young Deuk Choi, Eunju Choi, Youngkyu Song, Hosook Song
BACKGROUND: Cancer treatment-induced bone loss has important long-term effects in prostate cancer survivors (PCSs) receiving androgen deprivation therapy (ADT), but little is known about preventive interventions. OBJECTIVE: The aim of this study was to examine the feasibility and preliminary effectiveness of a 6-month home-based exercise intervention in PCSs. METHODS: In this pilot, randomized controlled trial, 51 men (mean age, 70.8 years) were randomized to a 6-month home-based exercise intervention for preventing osteoporosis group (n = 26) or an exercise placebo intervention of stretching exercise group (n = 25)...
July 20, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/28730888/preoperative-exercise-training-prevents-functional-decline-after-lung-resection-surgery-a-randomized-single-blind-controlled-trial
#5
Raquel Sebio García, Maria Isabel Yáñez-Brage, Esther Giménez Moolhuyzen, Marta Salorio Riobo, Ana Lista Paz, Jose María Borro Mate
OBJECTIVES: To investigate the effects of a preoperative pulmonary rehabilitation programme in patients with lung cancer undergoing video-assisted thoracic surgery. DESIGN: Randomized, single-blind controlled trial. SETTING: Teaching hospital. SUBJECTS: Patients with suspected or confirmed lung cancer undergoing video-assisted thoracic surgery. INTERVENTION: Participants were randomized to either a prehabilitation group or a control group...
August 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28727578/physical-activity-and-survival-in-women-with-advanced-breast-cancer
#6
Oxana Palesh, Charles Kamen, Susan Sharp, Ashleigh Golden, Eric Neri, David Spiegel, Cheryl Koopman
BACKGROUND: Several empirical investigations have attempted to characterize the effect of physical activity on cancer mortality, but these investigations have rarely focused on patients with advanced breast cancer. OBJECTIVE: The current study examined the hypothesis that greater physical activity is associated with longer survival among women with advanced breast cancer. METHODS: We conducted a secondary data analysis of a prospective study of 103 patients with stage IV (n = 100) or locally recurrent (n = 3) breast cancer involved in a group psychotherapy trial...
July 19, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/28723517/practice-patterns-compared-with-evidence-based-strategies-for-the-management-of-androgen-deprivation-therapy-induced-side-effects-in-prostate-cancer-patients-results-of-a-european-web-based-survey
#7
Renée Bultijnck, Cristian Surcel, Guillaume Ploussard, Alberto Briganti, Pieter De Visschere, Jurgen Fütterer, Pirus Ghadjar, Gianluca Giannarini, Hendrik Isbarn, Christophe Massard, Prasanna Sooriakumaran, Massimo Valerio, Roderick van den Bergh, Piet Ost
BACKGROUND: Evidence-based recommendations are available for the management of androgen deprivation therapy (ADT)-induced side effects; however, there are no data on the implementation of the recommendations into daily practice patterns. OBJECTIVE: To compare practice patterns in the management of ADT-induced side effects with evidence-based strategies. DESIGN, SETTING, AND PARTICIPANTS: A European Web-based survey was conducted from January 16, 2015, to June 24, 2015...
December 2016: European Urology Focus
https://www.readbyqxmd.com/read/28723375/the-effects-of-exercise-on-fatigue-quality-of-life-and-psychological-function-for-men-with-prostate-cancer-systematic-review-and-meta-analyses
#8
REVIEW
Vishal Vashistha, Balwinder Singh, Sukhdeep Kaur, Larry J Prokop, Dharam Kaushik
CONTEXT: Conflicting data exists on the role of exercise interventions in patients with prostate cancer (PCa) regarding quality of life (QOL) endpoints. OBJECTIVE: To evaluate the effects of exercise interventions on fatigue, QOL, depression, and anxiety in PCa patients. EVIDENCE ACQUISITION: We searched seven major databases (MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Web of Science, and Scopus) for randomized control trials (RCTs) of supervised exercise interventions for men with PCa from database inception to October 2015...
August 2016: European Urology Focus
https://www.readbyqxmd.com/read/28721554/feasibility-of-a-self-help-web-based-intervention-targeting-young-cancer-patients-with-sexual-problems-and-fertility-distress
#9
Maria Wiklander, Johanna Strandquist, Claire Micaux Obol, Lars E Eriksson, Jeanette Winterling, Kenny A Rodriguez-Wallberg, Kerstin Sjögren Fugl-Meyer, Johan Ahlgren, Per Ljungman, Claudia Lampic, Lena Wettergren
PURPOSE: The purpose of the study is to evaluate the feasibility of a self-help web-based intervention to alleviate sexual problems and fertility distress in adolescents and young adults with cancer. METHODS: Twenty-three persons with cancer (19 women and 4 men, age 18-43, 1-5 years post-diagnosis of lymphoma, breast, gynecologic, central nervous system, or testicular cancer) were recruited to test a 2-month web-based program targeting sexual problems or fertility distress...
July 18, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28720264/fatigue-and-health-related-quality-of-life-in-children-and-adolescents-with-cancer
#10
Michelle Darezzo Rodrigues Nunes, Eufemia Jacob, Emiliana Omena Bomfim, Luis Carlos Lopes-Junior, Regina Aparecida Garcia de Lima, Milena Floria-Santos, Lucila Castanheira Nascimento
PURPOSE: The study examined the different dimensions of fatigue (general, sleep/rest, cognitive), health related quality of life (HRQL) (physical, emotional, cognitive, social), and the relationships between fatigue and HRQL in hospitalized children and adolescents with cancer in Brazil. METHOD: Participants were recruited from a pediatric oncology inpatient unit in a comprehensive cancer care hospital in southeast Brazil. They completed the PedsQL Multidimensional Fatigue Scale and the PedsQL Inventory of Quality of Life (Generic and Cancer module) once during hospitalization...
August 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/28718864/-cognitive-behavioral-group-therapy-addressing-fear-of-progression-in-cancer-out-patients
#11
Bärbel Rudolph, Alexander Wünsch, Peter Herschbach, Andreas Dinkel
Fear of progression (FoP) is an appropriate, rational response to the real threat of cancer and its treatments. However, patients experiencing elevated, dysfunctional levels of FoP often feel severely distressed and are in need of treatment. We previously conducted a (partly-)randomized controlled study with cancer patients undergoing in-patient rehabilitation and showed that a brief, four-session cognitive-behavioral group therapy significantly reduced dysfunctional FoP. In this report, we describe the adaption of the cognitive-behavioral group therapy program for use with cancer out-patients...
June 29, 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/28718417/exercise-and-the-hallmarks-of-cancer
#12
REVIEW
Ana Ruiz-Casado, Asunción Martín-Ruiz, Laura M Pérez, Mariano Provencio, Carmen Fiuza-Luces, Alejandro Lucia
A wealth of evidence supports an association between regular physical activity (PA) and decreased risk for cancer and cancer mortality. This is clearly an important issue given the growing worldwide incidence of both cancer and physical inactivity. Of further importance is unraveling the biological mechanisms that explain the potential preventive effects of PA against the development of cancer, as this might improve our understanding of cancer biology and assist researchers exploring novel treatment strategies...
June 2017: Trends in Cancer
https://www.readbyqxmd.com/read/28716654/exercise-interventions-for-individuals-with-advanced-cancer-a-systematic-review
#13
Kim L Dittus, Robert E Gramling, Philip A Ades
Despite improvements in therapy a large proportion of individuals with cancer will have a shortened life expectancy because of advanced or metastatic disease. Advances in therapy have however, extended life in those with advanced cancer thus heightening the importance of living well and preventing decline. The burdens of disease and cancer therapy impair aerobic fitness, strength, physical function and quality of life (QOL). Fatigue, the most common side effect of cancer and cancer therapy can further deteriorate QOL...
July 14, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28716620/distinct-physical-function-profiles-in-older-adults-receiving-cancer-chemotherapy
#14
Christine Miaskowski, Melisa L Wong, Bruce A Cooper, Judy Mastick, Steven M Paul, Katherine Possin, Michael Steinman, Janine Cataldo, Laura B Dunn, Christine Ritchie
CONTEXT: While physical function is an important patient outcome, little is known about changes in physical function in older adults receiving chemotherapy (CTX). OBJECTIVES: Identify subgroups of older patients based on changes in their level of physical function; determine which demographic and clinical characteristics were associated with subgroup membership; and determine if these subgroups differed on quality of life (QOL) outcomes. METHODS: Latent profile analysis (LPA) was used to identify groups of older oncology patients (n=363) with distinct physical function profiles...
July 14, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28714766/cancer-related-fatigue-in-adolescents-and-young-adults-after-cancer-treatment-persistent-and-poorly-managed
#15
Anna Spathis, Helen Hatcher, Sara Booth, Faith Gibson, Paddy Stone, Laura Abbas, Matt Barclay, James Brimicombe, Pia Thiemann, Martin G McCabe, Rachel Campsey, Louise Hooker, Wendy Moss, Jane Robson, Stephen Barclay
Cancer-related fatigue is the most prevalent and distressing symptom experienced by adolescents and young adults (AYAs). An electronic survey was undertaken to ascertain current fatigue management and perceptions of its effectiveness. Eighty-five percent of responders (68/80) experienced fatigue, and it was worse more than 1 year after cancer treatment ended, compared to <1 year (p = 0.007). Forty-one percent received no fatigue management. Although advice to exercise was the most frequent intervention, the greatest impact of fatigue was on the ability to exercise and most did not find exercise advice helpful...
July 17, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28711382/recreational-physical-activity-in-relation-to-prostate-cancer-specific-mortality-among-men-with-nonmetastatic-prostate-cancer
#16
Ying Wang, Eric J Jacobs, Susan M Gapstur, Maret L Maliniak, Ted Gansler, Marjorie L McCullough, Victoria L Stevens, Alpa V Patel
BACKGROUND: Large prospective cohort studies need to confirm the associations between recreational physical activity (PA), including the most common type-walking, and prostate cancer-specific mortality (PCSM) among prostate cancer patients. OBJECTIVE: To investigate the associations of recreational PA, reported before and after diagnosis, with PCSM, overall and by tumor risk category. DESIGN, SETTING, AND PARTICIPANTS: In a prospective cohort study conducted in the USA, men diagnosed with nonmetastatic prostate cancer between 1992/1993 and June 2011 were followed for mortality until 2012...
July 12, 2017: European Urology
https://www.readbyqxmd.com/read/28710540/home-based-exercise-during-preoperative-therapy-for-pancreatic-cancer
#17
An Ngo-Huang, Nathan H Parker, Xuemei Wang, Maria Q B Petzel, David Fogelman, Keri L Schadler, Eduardo Bruera, Jason B Fleming, Jeffrey E Lee, Matthew H G Katz
PURPOSE: Exercise concurrent with neoadjuvant chemotherapy and/or chemoradiation for pancreatic adenocarcinoma (PDAC) may mitigate the decline in function that may occur as a result of the disease or its treatment in the preoperative period. The primary objective of this single-arm prospective trial was to determine adherence to a home-based exercise program administered during preoperative therapy. METHODS: Twenty patients from a quaternary cancer center with potentially resectable PDAC were enrolled...
July 15, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28708930/effects-of-high-intensity-aerobic-interval-training-on-cardiovascular-disease-risk-in-testicular-cancer-survivors-a-phase-2-randomized-controlled-trial
#18
Scott C Adams, Darren S DeLorey, Margie H Davenport, Michael K Stickland, Adrian S Fairey, Scott North, Alexander Szczotka, Kerry S Courneya
BACKGROUND: Testicular cancer survivors (TCS) have an increased risk of treatment-related cardiovascular disease (CVD), which may limit their overall survival. We evaluated the effects of high-intensity aerobic interval training (HIIT) on traditional and novel CVD risk factors and surrogate markers of mortality in a population-based sample of TCS. METHODS: This phase 2 trial (ClinicalTrials.gov identifier NCT02459132) randomly assigned 63 TCS to usual care (UC) or 12 weeks of supervised HIIT (ie, alternating periods of vigorous-intensity and light-intensity aerobic exercise)...
July 14, 2017: Cancer
https://www.readbyqxmd.com/read/28704159/one-does-not-fit-all-health-audience-segmentation-and-prediction-of-health-behaviors-in-cancer-prevention
#19
Myoung-Gi Chon, Hyojung Park
The purpose of this study is to propose a health belief model-based approach to segmenting health audiences in order to improve targeting of cancer prevention efforts. This study also examines how the identified health segments differ in cancer prevention behaviors. Using data from the 2013 Health Information National Trends Survey, a cluster analysis resulted in three distinct health audience groups: (a) health aware, (b) health at risk, and (c) health in confidence. MANOVA tests indicate that these segments differ significantly regarding healthy diet and exercise...
July 13, 2017: Health Marketing Quarterly
https://www.readbyqxmd.com/read/28702218/effects-of-a-parallel-arm-randomized-controlled-weight-loss-pilot-study-on-biological-and-psychosocial-parameters-of-overweight-and-obese-breast-cancer-survivors
#20
Andrea Y Arikawa, Beth C Kaufman, Susan K Raatz, Mindy S Kurzer
BACKGROUND: Weight gain often occurs after breast cancer (BC) diagnosis and obesity along with sedentary behavior are associated with increased risk of BC recurrence and mortality. The primary objective of this study was to determine whether a significant weight loss, of approximately 10%, would lead to beneficial changes in biomarkers associated with cancer and/or cancer recurrence, and quality of life (QOL) in overweight and obese BC survivors. METHODS: This parallel-arm study took place in Minneapolis, Minnesota, from January 2009 until March 2010...
2018: Pilot and Feasibility Studies
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