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https://www.readbyqxmd.com/read/29781589/right-mini-thoracotomy-bentall-with-traditional-and-automated-suturing-devices
#1
Carl Johnson, Juan Siordia, Davida Robinson, Peter Knight
Bentall procedures are traditionally performed through a median sternotomy. However, minimally invasive approaches are increasingly being utilized. A right mini-thoracotomy approach may improve postoperative recovery.  A 5-cm mini-thoracotomy is performed in the right 2nd intercostal space. A camera port is placed lateral to this incision. Peripheral cannulation is performed. The ascending aorta is cross-clamped. Cardioplegia is administered and the patient is placed in deep hypothermic circulatory arrest to construct the distal aortic anastomosis...
May 18, 2018: Multimedia Manual of Cardiothoracic Surgery: MMCTS
https://www.readbyqxmd.com/read/29781085/effect-of-hypothermia-treatment-on-gentamicin-pharmacokinetics-in-neonates-with-hypoxic-ischaemic-encephalopathy-a-systematic-review-and-meta-analysis
#2
REVIEW
D W Choi, J H Park, S Y Lee, S H An
WHAT IS KNOWN AND OBJECTIVE: Hypothermia is the current standard therapy for asphyxiated neonates with hypoxic-ischaemic encephalopathy (HIE). Gentamicin is used for the empirical treatment of early-onset neonatal sepsis. We investigated the influence of hypothermia treatment on gentamicin pharmacokinetics and suggested the appropriate dosing recommendations for gentamicin in neonates with HIE receiving hypothermia treatment. METHODS: We searched studies published until February 2017 in MEDLINE using PubMed, EMBASE and the Cochrane Library...
May 20, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29780723/cerebral-perfusion-issues-in-type-a-aortic-dissection
#3
REVIEW
Davide Pacini, Giacomo Murana, Luca Di Marco, Marianna Berardi, Carlo Mariani, Giuditta Coppola, Mariafrancesca Fiorentino, Alessandro Leone, Roberto Di Bartolomeo
Stroke events are very common in acute type A aortic dissection. Cerebral malperfusion could manifest at presentation due to prolonged arch vessels hypoperfusion or develop after surgery for inadequate cerebral protection during arch repair. To reduce this detrimental complication there are several adjuncts that can be adopted for cerebral protection such as direct antegrade or retrograde cerebral perfusion (RCP) and use period of deep to moderate hypothermic circulatory arrest time; however, they are often insufficient as preoperative malperfusion already caused irreversible ischemic damages...
2018: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29777174/how-does-blood-regulate-cerebral-temperatures-during-hypothermia
#4
Stephen Blowers, Ian Marshall, Michael Thrippleton, Peter Andrews, Bridget Harris, Iain Bethune, Prashant Valluri
Macro-modeling of cerebral blood flow can help determine the impact of thermal intervention during instances of head trauma to mitigate tissue damage. This work presents a bioheat model using a 3D fluid-porous domain coupled with intersecting 1D arterial and venous vessel trees. This combined vascular porous (VaPor) model resolves both cerebral blood flow and energy equations, including heat generated by metabolism, using vasculature extracted from MRI data and is extended using a tree generation algorithm...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29771394/the-effect-of-intraoperative-hypothermia-on-shoulder-arthroplasty
#5
Toufic R Jildeh, Kelechi R Okoroha, Nathan E Marshall, Chad Amato, Hunter Trafton, Stephanie J Muh, Patricia Kolowich
Limited evidence is available regarding the correlation between intraoperative hypothermia and perioperative complications in shoulder arthroplasty. The purpose of this study was to determine the incidence of intraoperative hypothermia in patients treated with shoulder arthroplasty and its effect on perioperative complications. A retrospective chart review was performed on 657 consecutive patients who underwent shoulder arthroplasty at a single institution between August 2013 and June 2016. Demographic data, surgery-specific data, postoperative complications, length of stay, and 30-day read-mission were recorded...
May 16, 2018: Orthopedics
https://www.readbyqxmd.com/read/29755800/hypothermia-in-multiple-sclerosis-beyond-the-hypothalamus-a-case-report-and-review-of-the-literature
#6
Francesco Berti, Zeeshan Arif, Cris Constantinescu, Bruno Gran
Hypothermia is a rare and poorly understood complication of Multiple Sclerosis (MS). We report on a 66-year-old patient currently with Secondary Progressive MS (SP-MS) who developed unexplained hypothermia associated with multiple hospitalisations and we review the literature on this topic. In our case, magnetic resonance imaging (MRI) of the brain failed to highlight hypothalamic disease, but spinal MRI identified a number of spinal cord lesions. Given the incidence and clinical significance of spinal involvement in MS and the hypothermic disturbances observed in high Spinal Cord Injury (SCI), we hypothesise that upper spinal cord pathology, along with hypothalamic and brainstem dysfunctions, can contribute to hypothermia...
2018: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/29752506/examination-of-intra-operative-core-temperature-in-joint-arthroplasty-a-single-institution-prospective-observational-study
#7
Jennifer R Matos, Julie R McSwain, Bethany J Wolf, J Wesley Doty, Sylvia H Wilson
PURPOSE: Peri-operative hypothermia is associated with increased blood loss, delayed wound healing, and surgical site infections. However, it is not known when or how rapidly hypothermia develops during arthroplasty. This study observed patients undergoing lower extremity arthroplasty to identify the times of greatest heat loss or gain. METHODS: This single-institution prospective observational study enrolled 120 patients undergoing elective knee or hip arthroplasty for peri-operative temporal temperature measurements at ten prespecified intervals...
May 11, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29746591/brown-adipose-tissue-plays-a-central-role-in-systemic-inflammation-induced-sleep-responses
#8
Éva Szentirmai, Levente Kapás
We previously identified brown adipose tissue (BAT) as a source of sleep-inducing signals. Pharmacological activation of BAT enhances sleep while sleep loss leads to increased BAT thermogenesis. Recovery sleep after sleep loss is diminished in mice that lack uncoupling protein 1 (UCP-1), and also in wild-type (WT) mice after sensory denervation of the BAT. Systemic inflammation greatly affects metabolism and the function of adipose tissue, and also induces characteristic sleep responses. We hypothesized that sleep responses to acute inflammation are mediated by BAT-derived signals...
2018: PloS One
https://www.readbyqxmd.com/read/29734422/effects-of-antifreeze-protein-supplementation-on-the-development-of-porcine-morulae-stored-at-hypothermic-temperatures
#9
T V Nguyen, F Tanihara, M Hirata, T Hirano, K Nishio, L T Kim Do, T V Nguyen, M Nii, T Otoi
BACKGROUND: Short-term storage is valuable method to reuse manipulated embryos. OBJECTIVE: The present study evaluated the effects of antifreeze protein (AFP) supplementation on the quality and development of in vitro-produced porcine morulae after short-term storage (24 h). MATERIALS AND METHODS: The morulae were stored with various concentrations of AFP type III for 24 h at 5, 15 and 25C. RESULTS: Supplementation of AFP type III (1...
March 2018: Cryo Letters
https://www.readbyqxmd.com/read/29732365/corticosteroids-in-pediatric-heart-surgery-myth-or-reality
#10
REVIEW
Daniel P Fudulu, Ben Gibbison, Thomas Upton, Serban C Stoica, Massimo Caputo, Stafford Lightman, Gianni D Angelini
Background: Corticosteroids have been administered prophylactically for more than 60 years in pediatric heart surgery, however, their use remains a matter of debate. There are three main indications for corticosteroid use in pediatric heart surgery with the use of cardiopulmonary bypass (CPB): (1) to blunt the systemic inflammatory response (SIRS) induced by the extracorporeal circuit; (2) to provide perioperative supplementation for presumed relative adrenal insufficiency; (3) for the presumed neuroprotective effect during deep hypothermic circulatory arrest operations...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29730345/hemiarch-reconstruction-vs-clamped-aortic-anastomosis-for-concomitant-ascending-aortic-aneurysm
#11
Ibrahim Sultan, Valentino Bianco, Ibrahim Yajzi, Arman Kilic, Keith Dufendach, Arturo Cardounel, Andrew D Althouse, Ahmad Masri, Forozan Navid, Thomas G Gleason
BACKGROUND: Deep hypothermic circulatory arrest (DHCA) is often avoided in patients with concomitant ascending aortic pathology when treating other cardiac disease to avoid increased risk of morbidity and mortality. We hypothesized that the use of DHCA with retrograde cerebral perfusion (RCP) does not add incremental risk to ascending aortic replacement alone in the setting of concomitant cardiac surgery. METHODS: 408 ascending aortic ± hemiarch replacements and aortic (root)/mitral/tricuspid valve(s), CABG, or MAZE procedures were performed for concomitant cardiac disease...
May 3, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29723082/microbial-analysis-of-donor-corneoscleral-rims-and-storage-media
#12
Edmund Tsui, Preston M Luong, Jessa Fogel, Erin S Fogel, Michael E Zegans
PURPOSE: We aim to investigate bacterial and fungal cultures of hypothermic donor corneal storage media (Optisol-GS) and donor rims. METHODS: All corneal transplants performed from January 1, 2015 to June 30, 2016 by a single surgeon at a single facility were retrospectively reviewed. Aerobic, anaerobic, and fungal cultures were routinely obtained from all donor rims and cornea storage media. Culture results and clinical courses were recorded. RESULTS: Eighty-four corneal transplants were performed...
May 3, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29721820/hypothermic-total-liquid-ventilation-after-experimental-aspiration-associated-acute-respiratory-distress-syndrome
#13
Jérôme Rambaud, Fanny Lidouren, Michaël Sage, Matthias Kohlhauer, Mathieu Nadeau, Étienne Fortin-Pellerin, Philippe Micheau, Luca Zilberstein, Nicolas Mongardon, Jean-Damien Ricard, Megumi Terada, Patrick Bruneval, Alain Berdeaux, Bijan Ghaleh, Hervé Walti, Renaud Tissier
BACKGROUND: Ultrafast cooling by total liquid ventilation (TLV) provides potent cardio- and neuroprotection after experimental cardiac arrest. However, this was evaluated in animals with no initial lung injury, whereas out-of-hospital cardiac arrest is frequently associated with early-onset pneumonia, which may lead to acute respiratory distress syndrome (ARDS). Here, our objective was to determine whether hypothermic TLV could be safe or even beneficial in an aspiration-associated ARDS animal model...
May 2, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29720479/scientific-rationale-for-changing-lower-water-temperature-limits-for-triathlon-racing-to-12%C3%A2-c-with-wetsuits-and-16%C3%A2-c-without-wetsuits
#14
Jane Saycell, Mitch Lomax, Heather Massey, Mike Tipton
OBJECTIVES: To provide a scientific rationale for lower water temperature and wetsuit rules for elite and subelite triathletes. METHODS: 11 lean, competitive triathletes completed a 20 min flume swim, technical transition including bike control and psychomotor testing and a cycle across five different wetsuit and water temperature conditions: with wetsuit: 10°C, 12°C and 14°C; without wetsuit (skins): 14°C and 16°C. Deep body (rectal) temperature (Tre ), psychomotor performance and the ability to complete a technical bike course after the swim were measured, as well as swimming and cycling performance...
May 2, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29710738/medico-legal-implications-of-hypothermic-neuroprotection-in-the-newborn
#15
S M Donn, J M Fanaroff
Hypoxic-ischemic encephalopathy (HIE) continues to be a significant source of long term neurological sequelae in infants born at or near term. In the past decade, selective head or whole body cooling has shown promising benefit in ameliorating some of the brain injury from intrapartum asphyxial insults and has become standard care in most developed countries. A decision to offer neuroprotective hypothermia (NPH) may engender subsequent litigation because it presupposes an acute intrapartum injury. Conversely, failing to offer cooling may be interpreted as a violation in the standard of care...
April 24, 2018: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29707437/expression-and-characterization-of-a-potential-exopolysaccharide-from-a-newly-isolated-halophilic-thermotolerant-bacteria-halomonas-nitroreducens-strain-wb1
#16
Arpitha Chikkanna, Devanita Ghosh, Abhinoy Kishore
The halophilic bacterial strain WB1 isolated from a hydrothermal vent was taxonomically characterized using multiple proxies, as Halomonas nitroreducens strain WB1. When grown on malt extract/yeast extract (MY) medium, it produced large quantities of exopolysaccharide (EPS). The polymer was synthesized at a higher rate during the log and early stationary phases. The anionic polysaccharide is primarily composed of glucose, mannose, and galactose. The studied EPS was highly viscous and had pseudoplastic nature...
2018: PeerJ
https://www.readbyqxmd.com/read/29707342/aortic-arch-repair-under-moderate-hypothermic-circulatory-arrest-with-or-without-antegrade-cerebral-perfusion-based-on-the-extent-of-repair
#17
Sung Jun Park, Bo Bae Jeon, Hee Jung Kim, Joon Bum Kim
Background: For aortic-arch repair, moderate hypothermic circulatory arrest (HCA) have shown favorable outcomes over conventional deep HCA when coupled with antegrade cerebral perfusion (ACP); however, recent studies have shown that ACP may not be essential when circulatory arrest time is less than 30 minutes. This study aims to evaluate the stratified arch repair strategy of moderate HCA with or without ACP based on the extent of procedure. Methods: Consecutive 138 patients (63 female; mean age, 60...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29707307/retrograde-perfusion-through-superior-vena-cava-reaches-the-brain-during-circulatory-arrest
#18
Mario Gaudino, Natalia Ivascu, Melissa Cushing, Christopher Lau, Ivancarmine Gambardella, Antonino Di Franco, Lucas B Ohmes, Monica Munjal, Leonard N Girardi
Background: The optimal technique for brain perfusion during circulatory arrest remains controversial. Concern exists that retrograde cerebral perfusion (RCP) via the superior vena cava (SVC) is unable to perfuse the brain. We evaluated whether RCP blood circulates through the brain parenchyma in humans during deep hypothermic circulatory arrest (DHCA). We hypothesized that a significant difference in the levels of S-100β (a protein with very high neuro-sensitivity) between the blood infused in the SVC and the effluent blood returning in the left carotid artery (CA) during RCP, should be regarded as a sign of the circulation of RCP blood through the brain parenchyma...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29704592/cytoprotective-antioxidant-and-anti-inflammatory-mechanism-related-to-antiulcer-activity-of-cissampelos-sympodialis-eichl-in-animal-models
#19
Igor Rafael Praxedes De Sales, Rodrigo De Oliveira Formiga, Flávia Danniele Frota Machado, Raphaela Francelino Nascimento, Matheus Marley Bezerra Pessoa, Monique Emanuela Frutuoso Xavier Barros, Giciane Carvalho Vieira, Francisco Allysson Assis Ferreira Gadelha, Alexsandro Fernandes Marinho, José Maria Barbosa Filho, Raimundo Fernandes De Araújo Júnior, Aurigena Araújo Antunes, Leônia Maria Batista
ETHNOPHARMACOLOGICAL RELEVANCE: The leaves and roots of Cissampelos sympodialis (Menispermaceae) are used by indian tribes and in folk medicine to treat genitourinary infections, inflammation, asthma and gastrointestinal disorders. MATERIAL AND METHODS: The standardized ethanolic extract (Cs-EtOHE) and alkaloids total fraction (Cs-TAF) obtained from aerial parts of C. sympodialis were evaluated in several models of acute gastric ulcers. The antisecretory and/or neutralizing mechanisms of the gastric acid secretion, cytoprotective, antioxidant and immunoregulatory mechanisms were also evaluated...
April 25, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29701386/simplified-technique-for-aortic-arch-replacement-in-patients-at-high-risk-for-frozen-elephant-trunk
#20
Álvaro Laranjeira Santos, António Cruz Tomás, Jorge Pinheiro Santos, Daniela Varela-Afonso, José Fragata
INTRODUCTION: Surgical approach of multisegmental pathology of the thoracic aorta, namely aortic arch / descending aorta is challenging. The Frozen Elephant Trunk (FET) has good results, with acceptable risk. However, in the subgroup of patients (pts) older than 75 years and with important comorbidities, the surgical risk is very high. OBJECTIVES: Review short-term results of this original, simplified and potentially hybrid technique developed in our Department for this subgroup of patients...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
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