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https://www.readbyqxmd.com/read/28526418/prevalence-of-measurable-disease-in-metastatic-castration-resistant-prostate-cancer
#1
Guru Sonpavde, Ankit Madan, Mary K Baker, Jori E May, Gurudatta Naik, Sejong Bae
BACKGROUND: Because of the low historical prevalence of measurable disease in metastatic castration-resistant prostate cancer (mCRPC), phase II trials have used prostate-specific antigen (PSA) and bone scan changes as primary end points. Frequent whole-body imaging and improved computed tomography technology currently identify measurable disease more frequently, warranting consideration of objective response as a major end point. PATIENTS AND METHODS: Data from reported phase III trials of mCRPC were analyzed...
April 26, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28523582/first-in-human-radiation-dosimetry-of-68-ga-nodaga-rgdyk
#2
Silvano Gnesin, Periklis Mitsakis, Francesco Cicone, Emmanuel Deshayes, Vincent Dunet, Augusto F Gallino, Marek Kosinski, Sébastien Baechler, Franz Buchegger, David Viertl, John O Prior
BACKGROUND: Integrin-targeting radiopharmaceuticals have potential broad applications, spanning from cancer theranostics to cardiovascular diseases. We have previously reported preclinical dosimetry results of (68)Ga-NODAGA-RGDyK in mice. This study presents the first human dosimetry of (68)Ga-NODAGA-RGDyK in the five consecutive patients included in a clinical imaging protocol of carotid atherosclerotic plaques. Five male patients underwent whole-body time-of-flight (TOF) PET/CT scans 10, 60 and 120 min after tracer injection (200 MBq)...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28522155/fibroelastic-pseudotumour-elastofibroma-dorsi-detected-by-18-f-fdg-pet-ct-and-by-posttherapy-radioiodine-spect-ct
#3
M Oporto, F Cepa, N Orta, S Rubí, H Navalón, C Peña
Radioiodine uptake in the thyroid tissue, metastasis of differentiated thyroid cancer (DTC), and in other tissues, depends on the expression of sodium-iodide symporter (NIS). Vascular permeability, effusions, inflammation, and other mechanisms may also play a role in the accumulation of radioactive iodine. A 63-year-old woman underwent radioiodine therapy, as well as a post-therapy whole-body scan,as she was suspected of having lung metastasis from thyroid carcinoma. The scan not only showed uptake at the lung metastasis but also a faint diffuse bilateral uptake in the posterior thorax...
May 15, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28514760/clinical-study-of-99mtc-3p-rgd2-peptide-imaging-in-osteolytic-bone-metastasis
#4
Guoqiang Shao, Wei Gu, Muhong Guo, Shiming Zang, Jinjing Fu, Shuang Liu, Feng Wang, Zizheng Wang
OBJECTIVE: To investigate the value of integrin αvβ3 targeted imaging with 99mTc-HYNIC-PEG4-E[PEG4-c(RGDfk)]2 (99mTc-3P-RGD2) as a radiotracer in dectecting osteolytic bone metastases. METHODS: This is a retrospective study involving a cohort of 69 consecutive patients including 59 with lung cancer and 10 with other cancers. Patients were required to receive whole body scan (WBS) and regional SPECT/CT imaging with 99mTc-3P-RGD2 (RGD imaging) and 99mTc-MDP (MDP imaging) as a radiotracer successively within days...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28507988/comparative-therapeutic-efficacy-of-153-sm-edtmp-and-177-lu-edtmp-for-bone-pain-palliation-in-patients-with-skeletal-metastases-patients-pain-score-analysis-and-personalized-dosimetry
#5
Sarika Sharma, Baljinder Singh, Ashwani Koul, Bhagwant Rai Mittal
INTRODUCTION: The aim of the present study was to compare the therapeutic efficacy of (153)Sm-EDTMP and (177)Lu-EDTMP in pain palliation in cancer patients with skeletal metastases. MATERIALS AND METHODS: Thirty patients (25 M:5 F, mean age: 66.0 ± 14.7 years) of breast/prostate cancer with documented skeletal metastases were recruited prospectively. Twenty patients were considered randomly for treatment with (153)Sm-EDTMP and with (177)Lu-EDTMP in 10 patients, respectively...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28501412/sudden-death-in-a-diver-a-diagnostic-conundrum
#6
Scott Dougherty, Maziar Khorsandi, Myra Adelbai, Vipin Zamvar, James Francis
We discuss the case of an experienced diver who ran out of air during his final ascent while scuba diving. He lost consciousness rapidly after surfacing and despite immediate cardiopulmonary resuscitation, could not be revived. On arrival at the emergency department he was noted to have copious amounts of blood in his upper airway and had developed extensive subcutaneous emphysema. Large amounts of air were observed in the central circulation following a postmortem computerized tomography scan as well as pneumomediastinum, a small right-sided hemothorax, and extensive subcutaneous emphysema...
May 10, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28495243/validation-of-topographic-hybrid-spect-ct-scan-in-patients-with-and-without-non-specific-chronic-low-back-pain-a-prospective-comparative-study
#7
Erik Van de Kelft, Gino Verleye, An-Sofie Van de Kelft, Koen Melis, Johan Van Goethem
Background/context The evidence for the treatment for non-specific chronic low back pain (ns CLBP) is very weak. Besides the complexity of the pain experience, a good biological marker or tool enabling identification of a pain generator is lacking. Hybrid imaging, combining Single Photon Emission Computerized Tomography (SPECT) with Computerized Tomography (CT)-scan, has been proposed as useful in the diagnostic workup of CLBP patients. Purpose To evaluate the sensitivity of SPECT-CT in patients with ns CLBP (group I) as compared to patients without CLBP (Group II)...
May 8, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28491193/indium-111-labeled-leukocyte-accumulation-in-extremity-soft-tissue-sarcoma
#8
Victor Fong, Lester Johnson
Nuclear medicine labeled leukocyte whole-body scintigraphy is commonly used to identify a source of infection in a patient with fever of unknown origin. White blood cells can also localize to other sites of inflammation, including sometimes tumors. A patient with a large myxofibrosarcoma in his left forearm was scanned due to chronic low-grade fever and persistent leukocytosis. This case demonstrates focal white blood cell activity in an extremity soft tissue sarcoma.
June 2017: Radiology case reports
https://www.readbyqxmd.com/read/28490472/-18-f-fdg-pet-ct-for-very-early-response-evaluation-predicts-ct-response-in-erlotinib-treated-nsclc-patients-a-comparison-of-assessment-methods
#9
Joan Fledelius, Anne Winther-Larsen, Azza Ahmed Khalil, Catharina Mølgaard Bylov, Karin Hjorthaug, Aksel Bertelsen, Jørgen Frøkiær, Peter Meldgaard
The purpose of this study was to determine which method for early response evaluation with (18)F-fluoro-D-glucose positron emission tomography combined with whole body computed tomography ((18)F-FDG-PET/CT) performed most optimal for prediction of response on a later CT-scan in erlotinib treated non-small cell lung cancer (NSCLC) patients. Methods:(18)F-FDG-PET/CT scans were performed prior to and after 7-10 days of erlotinib treatment in 50 NSCLC patients. The scans were evaluated using a qualitative approach and various semi-quantitative methods including percentage change in Standardized Uptake values, lean body mass corrected (SUL) SULpeak, SULmax and Total Lesion Glycolysis (TLG)...
May 10, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28489758/analysis-of-radioiodine-therapy-and-prognostic-factors-of-differentiated-thyroid-cancer-patients-with-pulmonary-metastasis-an-8-year-retrospective-study
#10
Renfei Wang, Yueqian Zhang, Jian Tan, Guizhi Zhang, Ruiguo Zhang, Wei Zheng, Yajing He
To assess the efficacy of radioiodine therapy (RIT) and investigate the prognostic factors for patients with pulmonary metastasis secondary to differentiated thyroid carcinoma (DTC) through a retrospective study. A total of 80 patients with radioactive iodine-131 (I)-avid pulmonary metastasis from DTC treated with I from 2007 to 2014 at our institution entered the study. Treatment response was mainly measured by two parameters: serum thyroglobulin (Tg) levels and post-therapeutic I whole-body scan (WBS). Treatment variables were assessed for statistical significance using the univariate and multivariate analyses...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28479481/a-shared-biomechanical-environment-for-bone-and-posture-development-in-children
#11
Fábio A Araújo, Ana Martins, Nuno Alegrete, Laura D Howe, Raquel Lucas
BACKGROUND CONTEXT: In each specific habitual standing posture, gravitational forces determine the mechanical setting provided to skeletal structures. Bone quality and resistance to physical stress is highly determined by habitual mechanical stimulation. However, the relationship between bone properties and sagittal posture has never been studied in children. PURPOSE: To investigate the association between bone physical properties and sagittal standing postural patterns in 7-year-old children...
May 4, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28474785/protein-timing-during-the-day-and-its-relevance-for-muscle-strength-and-lean-mass
#12
Samuel L Buckner, Jeremy P Loenneke, Paul D Loprinzi
Protein consumption and its association with changes in body composition, muscle function and different strategies to optimize the muscle protein synthetic response have received considerable attention. However, we are not aware of any epidemiological study examining the time-of-day consumption (afternoon versus evening) of protein on strength and lean mass. The purpose was to examine the associations between afternoon and evening protein consumption, at different protein thresholds (i.e. 15, 20, 25 and 30 g), in relation to leg lean mass and knee extensor strength in men...
May 5, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28473594/evaluation-of-sinus-edge-corrected-zte-based-attenuation-correction-in-brain-pet-mri
#13
Jaewon Yang, Florian Wiesinger, Sandeep Kaushik, Dattesh Shanbhag, Thomas A Hope, Peder E Z Larson, Youngho Seo
Purpose: In brain positron emission tomography/magnetic resonance imaging (PET/MRI), the major challenge of zero-echo-time (ZTE)-based attenuation correction (ZTAC) is the misclassification of air/tissue/bone mixtures or their boundaries. Our study aimed to evaluate a sinus/edge corrected (SEC) ZTAC (ZTACSEC), relative to an "uncorrected (UC)" ZTAC (ZTACUC) and a computed tomography (CT) atlas-based attenuation correction (ATAC). Materials and Methods: Whole-body fluorodeoxyglucose PET/MRI scans were performed for twelve patients, following PET/CT scans...
May 4, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28473069/acr-appropriateness-criteria-%C3%A2-back-pain-child
#14
Timothy N Booth, Ramesh S Iyer, Richard A Falcone, Laura L Hayes, Jeremy Y Jones, Nadja Kadom, Abhaya V Kulkarni, John S Myseros, Sonia Partap, Charles Reitman, Richard L Robertson, Maura E Ryan, Gaurav Saigal, Bruno P Soares, Aylin Tekes-Brady, Andrew T Trout, Nicholas A Zumberge, Brian D Coley, Susan Palasis
It is now generally accepted that nontraumatic back pain in the pediatric population is common. The presence of isolated back pain in a child has previously been an indication for imaging; however, recently a more conservative approach has been suggested using clinical criteria. The presence of constant pain, night pain, and radicular pain, alone or in combination, lasting for 4 weeks or more, constitute clinical red flags that should prompt further imaging. Without these clinical red flags, imaging is likely not indicated...
May 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28465871/a-rare-case-of-hibernoma-occasionally-identified-by-18f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-a-patient-with-lung-cancer
#15
Daniele Penna, Natale Quartuccio, Claudio Testa, Vincenzo Arena, Angelina Cistaro, Ettore Pelosi
Hibernoma is a benign tumor arising from brown fat tissue. Conventional imaging techniques are not able to differentiate it from other benign lesions or malignant fatty tumors. We report the case of a 73-year-old patient who underwent a thorax computed tomography (CT) and was then referred to our department for metabolic assessment of a solitary lung nodule. An F18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) scan was performed and demonstrated, in addition, a highly metabolic fat-containing lesion mimicking a malignant fatty tumor in the left great pectoralis muscle...
March 29, 2017: Curēus
https://www.readbyqxmd.com/read/28464372/validation-of-phantom-based-harmonization-for-patient-harmonization
#16
Joseph V Panetta, Margaret E Daube-Witherspoon, Joel S Karp
PURPOSE: To improve the precision of multicenter clinical trials, several efforts are underway to determine scanner-specific parameters for harmonization using standardized phantom measurements. The goal of this study was to test the correspondence between quantification in phantom and patient images and validate the use of phantoms for harmonization of patient images. METHODS: The National Electrical Manufacturers' Association image quality phantom with hot spheres was scanned on two time-of-flight PET scanners...
May 2, 2017: Medical Physics
https://www.readbyqxmd.com/read/28464316/imaging-features-from-pre-treatment-ct-scans-are-associated-with-clinical-outcomes-in-non-small-cell-lung-cancer-patients-treated-with-stereotactic-body-radiotherapy
#17
Qian Li, Jongphil Kim, Yoganand Balagurunathan, Ying Liu, Kujtim Latifi, Olya Stringfield, Alberto Garcia, Eduardo G Moros, Thomas J Dilling, Matthew B Schabath, Zhaoxiang Ye, Robert J Gillies
PURPOSE: To investigate whether imaging features from pre-treatment planning CT scans are associated with overall survival (OS), recurrence-free survival (RFS), and loco-regional recurrence-free survival (LR-RFS) after stereotactic body radiotherapy (SBRT) among non-small-cell lung cancer (NSCLC) patients. PATIENTS AND METHODS: A total of 92 patients (median age: 73 years) with stage I or IIA NSCLC were qualified for this study. A total dose of 50 Gy in 5 fractions was the standard treatment...
May 2, 2017: Medical Physics
https://www.readbyqxmd.com/read/28463990/the-presence-of-bacterial-microcolonies-on-the-maxillary-sinus-ciliary-epithelium-in-healthy-young-individuals
#18
Monika Morawska-Kochman, Krzysztof Marycz, Katarzyna Jermakow, Kamil Nelke, Wojciech Pawlak, Marek Bochnia
OBJECTIVE: The aim of this cross-sectional in vitro study was to evaluate the mucosal surfaces of healthy maxillary sinuses, explore different forms of bacterial microorganism colonies present on the mucous membrane, and determine a mucosal surface area they occupy. METHODS: Samples of the maxillary sinus mucosa were collected from 30 healthy patients (M = 11; F = 19). The material was obtained during the Le Fort I osteotomy performed during corrective jaw surgery...
2017: PloS One
https://www.readbyqxmd.com/read/28462734/faster-eating-rates-are-associated-with-higher-energy-intakes-during-an-ad-libitum-meal-higher-bmi-and-greater-adiposity-among-4%C3%A2-5-year-old-children-results-from-the-growing-up-in-singapore-towards-healthy-outcomes-gusto-cohort
#19
Anna Fogel, Ai Ting Goh, Lisa R Fries, Suresh A Sadananthan, S Sendhil Velan, Navin Michael, Mya-Thway Tint, Marielle V Fortier, Mei Jun Chan, Jia Ying Toh, Yap-Seng Chong, Kok Hian Tan, Fabian Yap, Lynette P Shek, Michael J Meaney, Birit F P Broekman, Yung Seng Lee, Keith M Godfrey, Mary F F Chong, Ciarán G Forde
Faster eating rates are associated with increased energy intake, but little is known about the relationship between children's eating rate, food intake and adiposity. We examined whether children who eat faster consume more energy and whether this is associated with higher weight status and adiposity. We hypothesised that eating rate mediates the relationship between child weight and ad libitum energy intake. Children (n 386) from the Growing Up in Singapore Towards Healthy Outcomes cohort participated in a video-recorded ad libitum lunch at 4·5 years to measure acute energy intake...
May 2, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28460200/caecal-leiomyoma-detected-by-whole-body-mri-in-a-patient-with-hodgkin-lymphoma-first-case-report
#20
D Albano, E Sinagra, C Patti, D Narese, A Agrusa, G Di Buono, D Raimondo, M Midiri, R Lagalla, M Galia
INTRODUCTION: Hodgkin Lymphoma (HL) is one of the most curable malignant diseases. Modern treatments, like the combined radiochemotherapy and stem cell transplantation, have increased the number of malignant disease survivors. However, HL survivors are at risk of long-term effects, including the development of solid tumors. Secondary neoplasms are a major cause of late morbidity and mortality following treatment for HL. CASE REPORT: We report the case of a male patient, treated for HL by chemotherapy, who developed a large leiomyoma of the cecum one year after the treatment...
January 2017: Il Giornale di Chirurgia
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