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https://www.readbyqxmd.com/read/28817456/role-of-various-semiquantitative-parameters-of-18f-fdg-pet-ct-studies-for-interim-treatment-response-evaluation-in-non-small-cell-lung-cancer
#1
Akshima Sharma, Anant Mohan, Ashu Seith Bhalla, Sreenivas Vishnubhatla, Anil Kumar Pandey, Chandra Sekhar Bal, Rakesh Kumar
PURPOSE: The aim of this study was to prospectively evaluate the role of various semiquantitative parameters obtained from fluorine-18 fluorodeoxyglucose (F-FDG) PET/CT in interim treatment response assessment in biopsy-proven non-small-cell lung cancer (NSCLC) and to find the best parameter, if any. MATERIALS AND METHODS: Totally, 32 patients (male/female: 25/7) with biopsy proven NSCLC and a mean age of 54.71±12.65 years were enrolled in the study. Each patient underwent whole-body F-FDG PET/CT scan after injecting 5...
August 16, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28815346/unilateral-cancer-associated-retinopathy-diagnosis-serology-and-treatment
#2
Dimitri Roels, Shinji Ueno, Cornelia D Talianu, Dafina Draganova, Mineo Kondo, Bart P Leroy
PURPOSE: To report a case of unilateral cancer-associated retinopathy (CAR) with clinical, serological and electroretinogram (ERG) normalization after aggressive cancer treatment combined with steroids and rituximab. METHODS: Work-up included extensive clinical and electrophysiological testing. Also, serological work-up for antiretinal antibodies and oncological screening was organized. RESULTS: A 45-year-old female presented with progressive photopsias, photophobia and relative central scotoma in the right eye since 6 weeks prior...
August 16, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28812019/whole-body-spect-ct-versus-planar-bone-scan-with-targeted-spect-ct-for-metastatic-workup
#3
Olivier Rager, René Nkoulou, Nadia Exquis, Valentina Garibotto, Claire Tabouret-Viaud, Habib Zaidi, Gaël Amzalag, Stephanie Anne Lee-Felker, Thomas Zilli, Osman Ratib
PURPOSE: The use of SPECT/CT in bone scans has been widespread in recent years, but there are no specific guidelines concerning the optimal acquisition protocol. Two strategies have been proposed: targeted SPECT/CT for equivocal lesions detected on planar images or systematic whole-body SPECT/CT. Our aim was to compare the diagnostic accuracy of the two approaches. METHODS: 212 consecutive patients with a history of cancer were referred for bone scans to detect bone metastases...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28811997/estimation-of-kidneys-and-urinary-bladder-doses-based-on-the-region-of-interest-in-18-fluorine-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-examination-a-preliminary-study
#4
Farida Aimi Mustapha, Farahnaz Ahmad Anwar Bashah, Ihsan M Yassin, Ahmad Saad Fathinul Fikri, Abdul Jalil Nordin, Hairil Rashmizal Abdul Razak
BACKGROUND: Kidneys and urinary bladder are common physiologic uptake sites of 18fluorine-fluorodeoxyglucose ((18)F-FDG) causing increased exposure of low energy ionizing radiation to these organs. Accurate measurement of organ dose is vital as (18)F-FDG is directly exposed to the organs. Organ dose from (18)F-FDG PET is calculated according to the injected (18)F-FDG activity with the application of dose coefficients established by International Commission on Radiological Protection (ICRP)...
June 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28806249/epidural-metastases-from-follicular-thyroid-cancer-mimicking-meningiomas-in-68ga-dotatate-pet
#5
Marcus Unterrainer, Harun Ilhan, Andrei Todica, Peter Bartenstein, Nathalie Lisa Albert
We report a woman with multifocal lesions suggestive of meningiomas in MRI, which also presented with high Ga-DOTATATE uptake in PET, a finding characteristic for meningioma. A whole-body staging due to a pathological fracture revealed multiple neoplastic lesions throughout the body without detection of a primary site. Subsequent pathological workup of a lung lesion revealed multifocal metastases from follicular thyroid cancer despite thyroidectomy 10 years ago (without pathological finding), and posttreatment scans after radioiodine therapy confirmed the multiple brain lesions to be metastases as well...
August 12, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28806238/68ga-psma-uptake-in-combined-hepatocellular-cholangiocarcinoma-with-skeletal-metastases
#6
Ramin Alipour, Sandeep Gupta, Scott Trethewey
Ga-PSMA PET is a rapidly evolving imaging modality for whole-body staging of prostate cancer. We report a case of a 70-year-old man with mildly elevated prostate-specific antigen (8.1 μg/L) and clinical suspicion of prostate cancer (osteoblastic metastases on radionuclide bone scan) who was referred for Ga-PSMA PET/CT for primary staging. Multiple Ga-PSMA-avid skeletal foci, mostly associated with lytic changes on low-dose CT, as well as hepatic foci of avid Ga-PSMA uptake, were identified. No abnormal focus of avid Ga-PSMA uptake was identified in the prostate...
August 12, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28800625/variability-in-quantitative-analysis-of-atherosclerotic-plaque-inflammation-using-18f-fdg-pet-ct
#7
Karel-Jan D F Lensen, Alper M van Sijl, Alexandre E Voskuyl, Conny J van der Laken, Martijn W Heymans, Emile F I Comans, Mike T Nurmohamed, Yvo M Smulders, Ronald Boellaard
BACKGROUND: 18F-FDG-PET(/CT) is increasingly used in studies aiming at quantifying atherosclerotic plaque inflammation. Considerable methodological variability exists. The effect of data acquisition and image analysis parameters on quantitative uptake measures, such as standardized uptake value (SUV) and target-to-background ratio (TBR) has not been investigated extensively. OBJECTIVE: The goal of this study was to explore the effect of several data acquisition and image analysis parameters on quantification of vascular wall 18F-FDG uptake measures, in order to increase awareness of potential variability...
2017: PloS One
https://www.readbyqxmd.com/read/28799318/giant-cell-arteritis-presenting-as-puo
#8
Sham Santhanam, Sampath Kumar Mani
Giant cell arteritis(GCA) is a primary granulomatous vasculitis affecting the large and medium sized arteries. We present here a case of GCA with pyrexia of unknown origin (PUO) as the presenting manifestation in the absence of other typical features. On evaluation, the patient had raised inflammatory markers with features of large vessel vasculitis on whole body PET-CT scan. The colour doppler ultrasonography(CDUS) of the temporal arteries showed bilateral halo sign. Since bilateral 'halo sign' is more specific for the diagnosis of GCA, temporal artery biopsy is not mandatory...
August 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28798033/a-prospective-study-comparing-99m-tc-hdp-planar-bone-scintigraphy-and-whole-body-spect-ct-with-18-f-fluoride-pet-ct-and-18-f-fluoride-pet-mri-for-diagnosing-bone-metastases
#9
Johan Löfgren, Jann Mortensen, Sine Hvid Rasmussen, Claus Madsen, Annika Loft, Adam Espe Hansen, Peter Oturai, Karl Erik Jensen, Mette Louise Mørk, Michala Reichkendler, Liselotte Højgaard, Barbara M Fischer
We prospectively evaluate and compare the diagnostic performance of (99m)Tc-HDP planar bone scintigraphy (pBS), (99m)Tc-HDP SPECT/CT, (18)F-NaF PET/CT and (18)F-NaF PET/MRI for the detection of bone metastases. Methods: 117 patients with histologically proven malignancy referred for clinical pBS were prospectively enrolled. pBS and whole-body SPECT/CT were performed followed by (18)F-NaF PET/CT within 9 days. (18)F-NaF PET/MRI was also performed in 46 patients. A "truth panel" including clinical follow-up served as standard of reference...
August 10, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28796115/cerebral-white-matter-structure-is-disrupted-in-gulf-war-veterans-with-chronic-musculoskeletal-pain
#10
Stephanie M VanRiper, Andrew L Alexander, Kelli F Koltyn, Aaron J Stegner, Laura D Ellingson, Daniel J Destiche, Ryan J Dougherty, Jacob B Lindheimer, Dane B Cook
Chronic musculoskeletal pain (CMP) affects ∼25% of the 700,000 Veterans deployed during the Persian Gulf War (1990-91). The cause of their pain is unknown and there are no efficacious treatments. A small body of literature suggests that brain abnormalities exist in Gulf War Veterans (GVs), yet relationships between brain abnormalities and disease symptoms remain largely unexplored. Our purpose was to compare white matter (WM) integrity between GVCMP and matched, healthy Veteran controls (GVCO) and investigate relationships between cerebral WM integrity and symptoms...
August 8, 2017: Pain
https://www.readbyqxmd.com/read/28791424/-to-stent-or-not-to-stent-immediate-emergency-surgery-with-laparoscopic-radical-colectomy-with-cme-and-primary-anastomosis-is-feasible-for-obstructing-left-colon-carcinoma
#11
Salomone Di Saverio, Arianna Birindelli, Edoardo Segalini, Matteo Novello, Anna Larocca, Francesco Ferrara, Gian Andrea Binda, Marco Bassi
Great debate exists in the initial acute management of large bowel obstruction from obstructing left colon carcinoma. While endoscopic stenting is well established as the first approach in the setting of palliative care of patients with advanced metastatic disease as well as a bridge to elective surgery in elderly patients who have an increased risk of postoperative mortality (age >70 years and/or ASA status ≥3), controversies exist regarding oncological safety and long-term outcomes of endoscopic colonic stenting in younger patients and ESGE Guidelines do not recommend SEMS placement in patients <70 and fit for curative surgery...
August 8, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28777652/semiquantitative-assessment-of-18-f-fdg-uptake-in-the-normal-skeleton-comparison-between-pet-ct-and-time-of-flight-simultaneous-pet-mri
#12
Ryogo Minamimoto, Guofan Xu, Mehran Jamali, Dawn Holley, Amir Barkhodari, Greg Zaharchuk, Andrei Iagaru
OBJECTIVE: Differences in the attenuation correction methods used in PET/CT scanners versus the newly introduced whole-body simultaneous PET/MRI reportedly result in differences in standardized uptake values (SUVs) in the normal skeleton. The aim of the study was to compare the semiquantitative FDG uptake in the normal skeleton using time-of-flight (TOF) PET/MRI versus PET/CT with and without TOF. SUBJECTS AND METHODS: Participants received a single FDG injection and underwent non-TOF and TOF PET/CT (n = 23) or non-TOF PET/CT and TOF PET/MRI (n = 50)...
August 4, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28770629/ipragliflozin-a-sodium-glucose-co-transporter-2-inhibitor-reduces-intrahepatic-lipid-content-and-abdominal-visceral-fat-volume-in-patients-with-type-2-diabetes
#13
Akio Ohta, Hiroyuki Kato, Satoshi Ishii, Yosuke Sasaki, Yuta Nakamura, Tomoko Nakagawa, Yoshio Nagai, Yasushi Tanaka
OBJECTIVE: We recently investigated the effect of ipragliflozin, a sodium glucose co-transporter-2 inhibitor (SGLT-2I), in Japanese patients with type 2 diabetes by a 24-week. SGLT-2Is also have an anti-obesity effect, and reduction of body fat has been demonstrated by indirect methods. However, evaluation of the effect on the total visceral fat volume and intrahepatic lipid content has not been performed. RESEARCH DESIGN AND METHODS: We measured the abdominal subcutaneous fat volume (SFV) and visceral fat volume (VFV) by whole abdominal CT scanning, the intrahepatic lipid (IHL) content by proton magnetic resonance spectroscopy (1H-MRS), and the fat mass index (FI) and appendicular skeletal mass index (ASMI) by dual X-ray absorptiometry (DXA) in 20 patients from our previous study...
August 3, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28766828/technical-note-no-increase-in-effective-dose-from-half-compared-to-full-rotation-pelvis-cone-beam-ct
#14
Pascal Hauri, Roger A Hälg, Uwe Schneider
PURPOSE: To image the abdomen of a patient with a gantry mounted imaging system of a linear accelerator, different cone beam computed tomography (CBCT) protocols are available. The whole-body dose of a full rotation abdomen CBCT and a half rotation CBCT was compared. In our clinic, both CBCT protocols are used in daily routine work. METHODS: With an adult anthropomorphic Alderson phantom, the whole-body dose per CBCT scan was measured with thermoluminescence dosimeters...
August 2, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28759518/assessment-of-organ-dosimetry-for-planning-repeat-treatments-of-high-dose-131i-mibg-therapy-123i-mibg-versus-posttherapy-131i-mibg-imaging
#15
Neeta Pandit-Taskar, Pat Zanzonico, Patrick Hilden, Irina Ostrovnaya, Jorge A Carrasquillo, Shakeel Modak
PURPOSE: To evaluate detailed organ-based radiation-absorbed dose for planning double high-dose treatment with I-MIBG. METHODS: In a prospective study, 33 patients with high-risk refractory or recurrent neuroblastoma were treated with high-dose I-MIBG. Organ dosimetry was estimated from the first I-MIBG posttherapy imaging and from subsequent I-MIBG imaging prior to the planned second administration. Three serial whole-body scans were performed per patient 2 to 6 days after I-MIBG therapy (666 MBq/kg or 18 mCi/kg) and approximately 0...
July 29, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28759400/body-composition-in-adolescents-during-treatment-with-selective-serotonin-reuptake-inhibitors
#16
Chadi A Calarge, James A Mills, Kathleen F Janz, Trudy L Burns, William H Coryell, Babette S Zemel
OBJECTIVES: To examine the independent contribution of major depressive disorder (MDD), generalized anxiety disorder (GAD), and selective serotonin reuptake inhibitors (SSRIs) to changes in body composition in older adolescents. METHODS: Medically healthy 15- to 20-year-olds who were unmedicated or within 1 month of starting an SSRI were prospectively followed. Psychiatric functioning and medication treatment were assessed monthly. Body Mass Index (BMI) was measured every 4 months...
July 2017: Pediatrics
https://www.readbyqxmd.com/read/28756622/fully-automatic-multi-organ-segmentation-in-normal-whole-body-magnetic-resonance-imaging-mri-using-classification-forests-cfs-convolutional-neural-networks-cnns-and-a-multi-atlas-ma-approach
#17
Ioannis Lavdas, Ben Glocker, Konstantinos Kamnitsas, Daniel Rueckert, Henrietta Mair, Amandeep Sandhu, Stuart A Taylor, Eric O Aboagye, Andrea G Rockall
PURPOSE: As part of a programme to implement automatic lesion detection methods for whole body magnetic resonance imaging (MRI) in oncology, we have developed, evaluated and compared three algorithms for fully automatic, multi-organ segmentation in healthy volunteers. METHODS: The first algorithm is based on classification forests (CFs), the second is based on 3D convolutional neural networks (CNNs) and the third algorithm is based on a multi-atlas (MA) approach...
July 30, 2017: Medical Physics
https://www.readbyqxmd.com/read/28755448/short-term-in%C3%A2-vivo-precision-of-whole-body-composition-measurements-on-the-horizon-a-densitometer
#18
Michael Nowitz, Paula Monahan
INTRODUCTION: Dual-energy X-ray absorptiometry (DXA) is increasingly being used to assess abnormalities in body composition associated with a wide variety of conditions including obesity, sarcopenia, diabetes, anorexia, human immunodeficiency virus lipodystrophy, malabsorption and neuromuscular disorders. The objective of this study was to determine the short-term in vivo precision and least significant change in serial body composition measurements provided by the Hologic Horizon A densitometer as there is no published, peer reviewed body composition precision data on Horizon scanners in the medical literature...
July 29, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28747889/distribution-of-silicified-microstructures-regulation-of-cinnamyl-alcohol-dehydrogenase-and-lodging-resistance-in-silicon-and-paclobutrazol-mediated-oryza-sativa
#19
Deivaseeno Dorairaj, Mohd Razi Ismail
Lodging is a phenomenon that affects most of the cereal crops including rice, Oryza sativa. This is due to the fragile nature of herbaceous plants whose stems are non-woody, thus affecting its ability to grow upright. Silicon (Si), a beneficial nutrient is often used to toughen and protect plants from biotic and abiotic stresses. Deposition of Si in plant tissues enhances the rigidity and stiffness of the plant as a whole. Silicified cells provide the much needed strength to the culm to resist breaking. Lignin plays important roles in cell wall structural integrity, stem strength, transport, mechanical support, and plant pathogen defense...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28747880/strong-functional-connectivity-among-homotopic-brain-areas-is-vital-for-motor-control-in-unilateral-limb-movement
#20
Pengxu Wei, Zuting Zhang, Zeping Lv, Bin Jing
The mechanism underlying brain region organization for motor control in humans remains poorly understood. In this functional magnetic resonance imaging (fMRI) study, right-handed volunteers were tasked to maintain unilateral foot movements on the right and left sides as consistently as possible. We aimed to identify the similarities and differences between brain motor networks of the two conditions. We recruited 18 right-handed healthy volunteers aged 25 ± 2.3 years and used a whole-body 3T system for magnetic resonance (MR) scanning...
2017: Frontiers in Human Neuroscience
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