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https://www.readbyqxmd.com/read/29455248/are-there-effects-of-age-gender-height-and-body-fat-on-the-functional-muscle-bone-unit-in-children-and-adults
#1
I Duran, K Martakis, S Hamacher, C Stark, O Semler, E Schoenau
The aim was to describe the effect of age, gender, height, different stages of human life, and body fat on the functional muscle-bone unit. All these factors had a significant effect on the functional muscle-bone unit and should be addressed when assessing functional muscle-bone unit in children and adults. INTRODUCTION: For the clinical evaluation of the functional muscle-bone unit, it was proposed to evaluate the adaptation of the bone to the acting forces. A frequently used parameter for this is the total body less head bone mineral content (TBLH-BMC) determined by dual-energy X-ray absorptiometry (DXA) in relation to the lean body mass (LBM by DXA)...
February 17, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29454545/characterization-of-urinary-stone-composition-by-use-of-whole-body-photon-counting-detector-ct
#2
Andrea Ferrero, Ralf Gutjahr, Ahmed F Halaweish, Shuai Leng, Cynthia H McCollough
RATIONAL AND OBJECTIVES: This study aims to investigate the performance of a whole-body, photon-counting detector (PCD) computed tomography (CT) system in differentiating urinary stone composition. MATERIALS AND METHODS: Eighty-seven human urinary stones with pure mineral composition were placed in four anthropomorphic water phantoms (35-50 cm lateral dimension) and scanned on a PCD-CT system at 100, 120, and 140 kV. For each phantom size, tube current was selected to match CTDIvol (volume CT dose index) to our clinical practice...
February 14, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29453681/-18-f-fpybf-2-a-new-f-18-labelled-amyloid-imaging-pet-tracer-biodistribution-and-radiation-dosimetry-assessment-of-first-in-man-18-f-fpybf-2-pet-imaging
#3
Ryuichi Nishii, Tatsuya Higashi, Shinya Kagawa, Chio Okuyama, Yoshihiko Kishibe, Masaaki Takahashi, Tomoko Okina, Norio Suzuki, Hiroshi Hasegawa, Yasuhiro Nagahama, Koichi Ishizu, Naoya Oishi, Hiroyuki Kimura, Hiroyuki Watanabe, Masahiro Ono, Hideo Saji, Hiroshi Yamauchi
OBJECTIVE: Recently, a benzofuran derivative for the imaging of β-amyloid plaques, 5-(5-(2-(2-(2- 18 F-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)- N-methylpyridin-2-amine ( 18 F-FPYBF-2) has been validated as a tracer for amyloid imaging and it was found that 18 F-FPYBF-2 PET/CT is a useful and reliable diagnostic tool for the evaluation of AD (Higashi et al. Ann Nucl Med, https://doi.org/10.1007/s12149-018-1236-1 , 2018). The aim of this study was to assess the biodistribution and radiation dosimetry of diagnostic dosages of 18 F-FPYBF-2 in normal healthy volunteers as a first-in-man study...
February 16, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29449445/evaluation-of-penalized-likelihood-estimation-reconstruction-on-a-digital-time-of-flight-pet-ct-scanner-for-18-f-fdg-whole-body-examinations
#4
Elin Lindström, Anders Sundin, Carlos Trampal, Lars Lindsjö, Ezgi Ilan, Torsten Danfors, Gunnar Antoni, Jens Sörensen, Mark Lubberink
Resolution and quantitative accuracy of positron emission tomography (PET) are highly influenced by the reconstruction method. Penalized likelihood estimation algorithms allow for fully convergent iterative reconstruction, generating a higher image contrast while limiting noise compared to ordered subsets expectation maximization (OSEM). In this study, block-sequential regularized expectation maximization (BSREM) was compared to time-of-flight OSEM (TOF-OSEM). Various strengths of noise penalization factor β were tested along with scan durations and transaxial field of views (FOVs) with the aim to evaluate the performance and clinical use of BSREM for 18 F-FDG-PET-computed tomography (CT), both in quantitative terms and in a qualitative visual evaluation...
February 15, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29444586/sex-differences-in-pericardial-adipose-tissue-assessed-by-pet-ct-and-association-with-cardiometabolic-risk
#5
Corey M Gill, Debora C Azevedo, Adriana L Oliveira, Edgar L Martinez-Salazar, Martin Torriani, Miriam A Bredella
Background Recent studies suggest that pericardial adipose tissue (PAT) is associated with whole body adiposity and insulin resistance. Moreover, the incidence of cardiovascular disease (CVD) differs between men and women. Although CVD is more prevalent in men, women suffering from CVD have a higher mortality compared to men. Differences in PAT may account for some of the observed sex differences in manifestations of CVD. Purpose To assess pericardial adipose tissue (PAT) as a biomarker for cardiometabolic risk and to assess potential sex differences...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29444120/computer-tomography-based-body-surface-area-evaluation-for-drug-dosage-quantitative-radiology-versus-anthropomorphic-evaluation
#6
Antoine Iannessi, Hubert Beaumont, Christophe Hebert, Claire Dittlot, Marie Noëlle Falewee
OBJECTIVE: The measure of body surface area (BSA) is a standard for planning optimal dosing in oncology. This index is derived from a model having questionable performances. In this study, we proposed measurement of BSA from whole body CT images (iBSA). We tested the reliability of iBSA assessments and simulated the impact of our approach on patient chemotherapy dosage planning. METHODS: We first evaluated accuracy and precision of iBSA in measuring 14 phantom and 11 CT test-retest images...
2018: PloS One
https://www.readbyqxmd.com/read/29442350/occult-phosphaturic-mesenchymal-tumor-of-femur-cortex-causing-oncogenic-osteomalacia-diagnostic-challenges-and-clinical-outcomes
#7
Deep Dutta, Raghuvansh Kumar Pandey, Rakhee Gogoi, Nagender Solanki, Renu Madan, Anupam Mondal, Shruti Dogra, Pradeep Thapa
BACKGROUND: Tumor induced osteomalacia (TIO) are extremely rare paraneoplastic syndrome with less than 300 reported cases. This report highlights the pitfalls and challenges in diagnosing and localizing TIO in patients with refractory and resistant osteomalacia. PATIENT AND METHODS: 41- year gentleman with 4-year history of musculoskeletal weakness and pathologic fractures presented in wheelchair bound incapacitated state of 1-year duration. Investigations were significant for severe hypophosphatemia, severe phosphaturia, normal serum calcium, reduced 1,25-dihydroxy vitamin-D, elevated ALP, elevated intact parathyroid hormone (iPTH), and pseudo-fractures involving pelvis and bilateral femur...
February 14, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29434189/ablation-of-protein-phosphatase-5-pp5-leads-to-enhanced-both-bone-and-cartilage-development-in-mice
#8
Jun Wang, Yong Cao, Bin Qiu, Jianyong Du, Tingting Wang, Chao Wang, Ran Deng, Xudong Shi, Kai Gao, Zhongwen Xie, Weidong Yong
This study aimed to investigate the role of protein phosphatase 5 (PP5) on bone and cartilage development using both in vivo and in vitro approaches. Six- to 8-week- old male PP5 knockout mice (KO) and their wild-type (WT) littermate controls were randomly selected for this study, and their body weights and bone (femur) lengths were measured. Micro-computed tomography scanning (Micro-CT) was performed to determine femoral bone density and micro-architecture. Mesenchymal stem cells (MSCs) isolated from bone marrow were used to examine the effects of PP5 on osteogenesis in vitro...
February 12, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29431234/barium-titanate-microparticles-as-potential-carrier-platform-for-lanthanide-radionuclides-for-their-use-in-the-treatment-of-arthritis
#9
Sudipta Chakraborty, K V Vimalnath, Jyothi Sharma, Priyalata Shetty, H D Sarma, Rubel Chakravarty, Deep Prakash, P K Sinha, Ashutosh Dash
Since the inception of radiation synovectomy, a host of radioactive colloids and microparticles incorporating suitable therapeutic radionuclides have been proposed for the treatment of arthritis. The present article reports the synthesis and evaluation of barium titanate microparticles as an innovative and effective carrier platform for lanthanide radionuclides in the preparation of therapeutic agents for treatment of arthritis. The material was synthesized by mechanochemical route and characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), surface area and particle size distribution analyses...
February 12, 2018: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29428075/automatic-liver-detection-and-standardised-uptake-value-evaluation-in-whole-body-positron-emission-tomography-computed-tomography-scans
#10
Stephane Chauvie, Elisa Bertone, Fabrizio Bergesio, Alessandra Terulla, Davide Botto, Piergiorgio Cerello
BACKGROUND AND OBJECTIVE: Standardised Uptake Value (SUV), in clinical research and practice, is a marker of tumour avidity in Positron Emission Tomography/Computed Tomography (PET/CT). Since many technical, physical and physiological factors affect the SUV absolute measurement, the liver uptake is often used as reference value both in quantitative and semi-quantitative evaluation. The purpose of this investigation was to automatically detect the liver position in whole-body PET/CT scans and extract its average SUV value...
March 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29419481/noninvasive-whole-body-imaging-of-phosphatidylethanolamine-as-a-cell-death-marker-using-99mtc-duramycin-during-tnf-induced-sirs
#11
Tinneke Delvaeye, Leonie Wyffels, Steven Deleye, Kelly Lemeire, Amanda Gonçalves, Elke Decrock, Steven Staelens, Luc Leybaert, Peter Vandenabeele, Dmitri Krysko
Systemic inflammatory response syndrome (SIRS) is an inflammatory state affecting the whole body. It is associated with the presence of pro- and anti-inflammatory cytokines in serum, including tumor necrosis factor (TNF). TNF has multiple effects and leads to cytokine production, leukocyte infiltration, blood pressure reduction and coagulation, thereby contributing to tissue damage and organ failure. A sterile mouse model of sepsis, TNF-induced SIRS, was used to visualize the temporal and spatial distribution of damage in susceptible tissues during SIRS...
February 1, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29416344/incidence-of-traumatic-carotid-and-vertebral-artery-dissections-results-of-cervical-vessel-computed-tomography-angiogram-as-a-mandatory-scan-component-in-severely-injured-patients
#12
Andreas Schicho, Lukas Luerken, Ramona Meier, Antonio Ernstberger, Christian Stroszczynski, Andreas Schreyer, Lena-Marie Dendl, Stephan Schleder
Purpose: The aim of this study was to evaluate the true incidence of cervical artery dissections (CeADs) in trauma patients with an Injury Severity Score (ISS) of ≥16, since head-and-neck computed tomography angiogram (CTA) is not a compulsory component of whole-body trauma computed tomography (CT) protocols. Patients and methods: A total of 230 consecutive trauma patients with an ISS of ≥16 admitted to our Level I trauma center during a 24-month period were prospectively included...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29415060/precision-of-mri-based-body-composition-measurements-of-postmenopausal-women
#13
Janne West, Thobias Romu, Sofia Thorell, Hanna Lindblom, Emilia Berin, Anna-Clara Spetz Holm, Lotta Lindh Åstrand, Anette Karlsson, Magnus Borga, Mats Hammar, Olof Dahlqvist Leinhard
OBJECTIVES: To determine precision of magnetic resonance imaging (MRI) based fat and muscle quantification in a group of postmenopausal women. Furthermore, to extend the method to individual muscles relevant to upper-body exercise. MATERIALS AND METHODS: This was a sub-study to a randomized control trial investigating effects of resistance training to decrease hot flushes in postmenopausal women. Thirty-six women were included, mean age 56 ± 6 years. Each subject was scanned twice with a 3...
2018: PloS One
https://www.readbyqxmd.com/read/29409659/development-of-a-positioning-aid-to-reduce-postural-variability-and-errors-in-3d-whole-body-scan-measurements
#14
Frank Schwarz-Müller, Russell Marshall, Steve Summerskill
Three-dimensional (3D) body scanners have the potential to evaluate changes to the human form through different clothing configurations, the use of protective equipment, or the effects of medical interventions. To achieve this, scans of an individual need to be superimposed for each experimental condition. The literature highlights that one of the limiting factors is postural variability. This paper describes a newly developed 'positioning aid' that stabilises the posture during the scanning process and is invisible on scans...
April 2018: Applied Ergonomics
https://www.readbyqxmd.com/read/29403246/surgical-management-of-c-type-subaxial-cervical-fractures-using-cervical-traction-followed-by-anterior-cervical-discectomy-and-fusion-within-12-h-after-the-trauma
#15
Pasquale Donnarumma, Vincenzo Bozzini, Gaetano Rizzi, Arturo Berardi, Gaetano Merlicco
Study Design: This was a retrospective cohort study. Objective: To report our 10-year experience of closed reduction using Crutchfield traction followed by anterior cervical discectomy and fusion within 12 h from injury for C-type subaxial cervical fractures (according to the AOSpine classification system). Methods: Clinical records and neuroimaging were retrospectively reviewed. Surgical details were provided. Results: A total of 22 patients were included in the study...
October 2017: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/29401151/spect-ct-with-the-psma-ligand-99mtc-mip-1404-for-whole-body-primary-staging-of-patients-with-prostate-cancer
#16
Christian Schmidkonz, Michael Cordes, Michael Beck, Theresa Ida Goetz, Daniela Schmidt, Olaf Prante, Tobias Bäuerle, Michael Uder, Bernd Wullich, Peter Goebell, Torsten Kuwert, Philipp Ritt
BACKGROUND: Tc-MIP-1404 (Progenics Pharmaceuticals, Inc, New York, NY) is a novel ligand binding to prostate-specific membrane antigen suitable for SPECT. There are, as yet, no data concerning its use in whole-body primary staging and its interobserver variability in patients with prostate cancer (PC) prior to therapy. METHODS: A search of our clinical database from April 2013 to May 2017 yielded 93 patients with histologically confirmed cancer in whom Tc-MIP-1404 SPECT/CT had been performed for primary whole-body staging before therapy...
February 3, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29401147/spect-ct-mibg-imaging-is-crucial-in-the-follow-up-of-the-patients-with-high-risk-neuroblastoma
#17
Bin Liu, Sabah Servaes, Hongming Zhuang
BACKGROUND: Planar whole-body imaging with I-radiolabeled metaiodobenzylguanidine (I-MIBG) is routinely used in the follow-up evaluation of neuroblastoma. In recent years, SPECT with integrated low-dose CT (SPECT/CT) has become more accessible. We investigated how much SPECT/CT can have additional diagnostic value over planar imaging in detection of residual and recurrent neuroblastoma. METHODS: A total of 170 planar I-MIBG imaging scans with SPECT/CT follow-up scans performed in 147 patients with known high-risk neuroblastoma were retrospectively analyzed...
February 3, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29401146/177lu-prostate-specific-membrane-antigen-super-scan-and-good-response-even-after-1-cycle-of-radioligand-therapy
#18
Kamran Aryana, Soroush Zarehparvar Moghadam, Roham Salek, Ghasemali Divband
A 76-year-old man with castration-resistant prostate cancer and widespread skeletal metastases underwent 2 cycles of Lu-prostate-specific membrane antigen (PSMA) 617 therapy in our department. Whole-body Lu-PSMA scan after the first cycle showed diffuse skeletal PSMA-avid lesions, whereas no PSMA uptake was evident in the kidneys with minimal PSMA uptake by salivary glands (super scan). After 6 weeks, he received the second dose of Lu-PSMA and whole-body scan after the treatment showed remarkable resolution of skeletal metastases and normal PSMA uptake by the kidneys and salivary glands...
February 3, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29396817/renal-medullary-carcinoma-a-nearly-fatal-malignancy-specifically-affecting-patients-with-a-so-called-benign-condition
#19
Yamila Goenaga-Vázquez, Gloria Colón, Nilka Barrios, María Correa
Renal medullary carcinoma (RMC) is a highly aggressive and rare malignancy found almost exclusively in young patients with sickle cell trait (SCT). Metastatic disease is commonly present at diagnosis. There is very limited experience treating disseminated disease and the prognosis is dismal. We report the case of a young 9-year-old boy with SCT, who presented with 4 months' progression of abdominal pain, nausea and vomiting associated with cough spells, dysphagia, and weight loss. Upon evaluation, he was underweight, pale, and in mild respiratory distress...
February 2, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29396705/biokinetics-dosimetry-and-radiation-risk-in-infants-after-99mtc-mag3-scans
#20
J Soares Machado, J Tran-Gia, S Schlögl, A K Buck, M Lassmann
BACKGROUND: Renal scans are among the most frequent exams performed on infants and toddlers. Due to the young age, this patient group can be classified as a high-risk group with a higher probability for developing stochastic radiation effects compared to adults. As there are only limited data on biokinetics and dosimetry in this patient group, the aim of this study was to reassess the dosimetry and the associated radiation risk for infants undergoing 99mTc-MAG3 renal scans based on a retrospective analysis of existing patient data...
February 2, 2018: EJNMMI Research
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