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https://www.readbyqxmd.com/read/29234903/biodistribution-and-radiation-dosimetry-of-64cu-copper-dichloride-first-in-human-study-in-healthy-volunteers
#1
M A Avila-Rodriguez, C Rios, J Carrasco-Hernandez, J C Manrique-Arias, R Martinez-Hernandez, F O García-Pérez, A R Jalilian, E Martinez-Rodriguez, M E Romero-Piña, A Diaz-Ruiz
BACKGROUND: In recent years, Copper-64 (T1/2 = 12.7 h) in the chemical form of copper dichloride ([64Cu]CuCl2) has been identified as a potential agent for PET imaging and radionuclide therapy targeting the human copper transporter 1, which is overexpressed in a variety of cancer cells. Limited human biodistribution and radiation dosimetry data is available for this tracer. The aim of this research was to determine the biodistribution and estimate the radiation dosimetry of [64Cu]CuCl2, using whole-body (WB) PET scans in healthy volunteers...
December 12, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/29228071/associations-between-tau-%C3%AE-amyloid-and-cognition-in-parkinson-disease
#2
Joseph R Winer, Anne Maass, Peter Pressman, Jordan Stiver, Daniel R Schonhaut, Suzanne L Baker, Joel Kramer, Gil D Rabinovici, William J Jagust
Importance: Multiple disease processes are associated with cognitive impairment in Parkinson disease (PD), including Lewy bodies, cerebrovascular disease, and Alzheimer disease. It remains unknown whether tau pathology relates to cognition in patients with PD without dementia. Objective: To compare tau aggregation in patients with PD who are cognitively normal (PD-CN), patients with PD with mild cognitive impairment (PD-MCI), and healthy control participants, and evaluate the relationships between β-amyloid (Aβ), tau, and cognition in patients with PD who did not have dementia...
December 11, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29224048/comparison-between-whole-body-and-head-and-neck-neurovascular-coils-for-3-t-magnetic-resonance-proton-resonance-frequency-shift-thermography-guidance-in-the-head-and-neck-region
#3
Daniel Thomas Ginat, Gregory J Anthony, Gregory Christoforidis, Aytekin Oto, Leonard Dalag, Steffen Sammet
The purpose of this study is to compare the image quality of magnetic resonance (MR) treatment planning images and proton resonance frequency (PRF) shift thermography images and inform coil selection for MR-guided laser ablation of tumors in the head and neck region. Laser ablation was performed on an agar phantom and monitored via MR PRF shift thermography on a 3-T scanner, following acquisition of T1-weighted (T1W) planning images. PRF shift thermography images and T2-weighted (T2W) planning images were also performed in the neck region of five normal human volunteers...
December 9, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29212868/painful-testicular-metastasis-from-prostate-adenocarcinoma
#4
Karla A Lee, Erik Mayer, Vincent Khoo
A 60-year-old man presented with unilateral testicular pain and urinary frequency. His presenting prostate-specific antigen (PSA) was 100 ng/mL, and a biopsy revealed Gleason 4+4 prostate adenocarcinoma. The significance of his initial PSA was somewhat complicated by possible prostatitis and early initiation of bicalutamide. PSA rose on two occasions prior to radiotherapy but coincided with a flare of testicular pain on one of these. Whole-body staging diffusion-weighted MRI scan was negative. He was treated with 3 years of androgen deprivation therapy (ADT) and radical radiotherapy...
December 5, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29209416/reliability-of-analysis-of-the-bone-mineral-density-of-the-second-and-fifth-metatarsals-using-dual-energy-x-ray-absorptiometry-dxa
#5
N Stewart Pritchard, James M Smoliga, Anh-Dung Nguyen, Micah C Branscomb, David R Sinacore, Jeffrey B Taylor, Kevin R Ford
Background: Metatarsal fractures, especially of the fifth metatarsal, are common injuries of the foot in a young athletic population, but the risk factors for this injury are not well understood. Dual-energy x-ray absorptiometry (DXA) provides reliable measures of regional bone mineral density to predict fracture risk in the hip and lumbar spine. Recently, sub-regional metatarsal reliability was established in fresh cadaveric specimens and associated with ultimate fracture force. The purpose of this study was to assess the reliability of DXA bone mineral density measurements of sub-regions of the second and fifth metatarsals in a young, active population...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/29193340/template-based-field-map-prediction-for-rapid-whole-brain-b0-shimming
#6
Yuhang Shi, S Johanna Vannesjo, Karla L Miller, Stuart Clare
PURPOSE: In typical MRI protocols, time is spent acquiring a field map to calculate the shim settings for best image quality. We propose a fast template-based field map prediction method that yields near-optimal shims without measuring the field. METHODS: The template-based prediction method uses prior knowledge of the B0 distribution in the human brain, based on a large database of field maps acquired from different subjects, together with subject-specific structural information from a quick localizer scan...
November 28, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29192363/quantitative-and-visual-assessments-toward-potential-sub-msv-or-ultrafast-fdg-pet-using-high-sensitivity-tof-pet-in-pet-mri
#7
Spencer C Behr, Emma Bahroos, Randall A Hawkins, Lorenzo Nardo, Vahid Ravanfar, Emily V Capbarat, Youngho Seo
PURPOSE: Newer high-performance time-of-flight (TOF) positron emission tomography (PET) systems have the capability to preserve diagnostic image quality with low count density, while maintaining a high raw photon detection sensitivity that would allow for a reduction in injected dose or rapid data acquisition. To assess this, we performed quantitative and visual assessments of the PET images acquired using a highly sensitive (23.3 cps/kBq) large field of view (25-cm axial) silicon photomultiplier (SiPM)-based TOF PET (400-ps timing resolution) integrated with 3 T-MRI in comparison to PET images acquired on non-TOF PET/x-ray computed tomography (CT) systems...
November 30, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29191855/comparison-of-68ga-ops202-68ga-nodaga-jr11-and-68ga-dotatoc-68ga-edotreotide-pet-ct-in-patients-with-gastroenteropancreatic-neuroendocrine-tumors-evaluation-of-sensitivity-in-a-prospective-phase-ii-imaging-study
#8
Guillaume P Nicolas, Nils Schreiter, Felix Kaul, John Uiters, Hakim Bouterfa, Jens Kaufmann, Tobias E Erlanger, Richard Cathomas, Emanuel Christ, Melpomeni Fani, Damian Wild
Radiolabeled somatostatin receptor (sst) agonists are integral to the diagnosis of gastroenteropancreatic neuroendocrine tumors (GEP-NETs), but detection rates, especially of liver metastases, remain disappointing even with PET/CT. 68Ga-OPS202 (68Ga-NODAGA-JR11), a novel radiolabeled sst antagonist with a high affinity for sst2, has the potential to perform better than sst agonists. Here we present the results of the Phase II component of a Phase I/II study, which evaluated the sensitivity of 68Ga-OPS202 PET/CT compared with the reference compound, 68Ga-DOTATOC (sst agonist)...
November 30, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29189489/utility-of-whole-body-head-to-toe-pet-ct-in-the-evaluation-of-melanoma-and-sarcoma-patients
#9
Heather R Webb, Hamid R Latifi, Landis K Griffeth
OBJECTIVE: The aim of this study was to assess the added benefit of whole-body (head-to-toes) PET/CT versus routine 'eyes-to-thighs' PET/CT of melanoma and sarcoma patients. PATIENTS AND METHODS: We performed a retrospective review of consecutive whole-body PET/CT scans from January 2006 through December 2010 in patients with melanoma or sarcoma. PET abnormalities in the brain, distal thighs, and legs were recorded and clinical significance was assessed on the basis of pathology, imaging studies, and clinical follow-up...
November 17, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29181429/lung-nodule-volume-quantification-and-shape-differentiation-with-an-ultra-high-resolution-technique-on-a-photon-counting-detector-computed-tomography-system
#10
Wei Zhou, Juan Montoya, Ralf Gutjahr, Andrea Ferrero, Ahmed Halaweish, Steffen Kappler, Cynthia McCollough, Shuai Leng
An ultra-high resolution (UHR) mode, with a detector pixel size of [Formula: see text] relative to isocenter, has been implemented on a whole body research photon-counting detector (PCD) computed tomography (CT) system. Twenty synthetic lung nodules were scanned using UHR and conventional resolution (macro) modes and reconstructed with medium and very sharp kernels. Linear regression was used to compare measured nodule volumes from CT images to reference volumes. The full-width-at-half-maximum of the calculated curvature histogram for each nodule was used as a shape index, and receiver operating characteristic analysis was performed to differentiate sphere- and star-shaped nodules...
October 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29170332/35%C3%A2-to-pan-scan-or-not-to-pan-scan-further-analysis-of-the-tarn-database-2012-2017
#11
Paul Hunt, Fiona Lecky, Omar Bouamra
BACKGROUND: A 'whole body' or 'pan-scan' computed tomography (CT) imaging approach is now becoming the standard of care during the early management of adult patients with suspected severe blunt multitrauma. A number of studies have variously reported a mortality benefit or no benefit from a pan-scan approach compared to that of carrying out body region-focused CT and/or plain radiographs or a mixture of imaging modalities. However, unanswered questions still remain due to the significant heterogeneity in practice between institutions, and the limitations of published studies...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29170300/3%C3%A2-derivation-and-internal-validation-of-a-clinical-decision-rule-to-guide-whole-body-computed-tomography-scanning-in-trauma
#12
Hridesh Chatha, Ian Sammy, Rick Body, Abdo Sattout, John Hollingsworth
BACKGROUND: There are no widely accepted validated clinical decision rules for the use of WBCT in trauma. Given the potential risks and costs, there is a clear need for a clinical decision rule (CDR) to safely guide targeted use of WBCT. We aimed to derive a CDR to guide clinical decisions on WBCT utilisation by detecting patients at high and low risk of multi-region trauma. METHODS: We retrospectively identified consecutive patients who had presented to a major trauma centre with suspected major trauma...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29168981/high-resolution-rapid-neonatal-whole-body-composition-using-3-0-tesla-chemical-shift-magnetic-resonance-imaging
#13
Jonathan P Dyke, Amanda C Garfinkel, Alan M Groves, Arzu Kovanlikaya
BACKGROUND: To evaluate a whole body rapid imaging technique to calculate neonatal lean body mass and percentage adiposity using 3.0 Tesla chemical shift Magnetic Resonance Imaging (MRI). METHODS: A 2-Point Dixon MRI technique was used to calculate whole body fat and water images in term (n=10) and preterm (n=15) infants. RESULTS: Chemical shift images were obtained in 42 s. MRI calculated whole body mass correlated closely with measured body weight (R(2)=0...
November 23, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29166327/68ga-prostate-specific-membrane-antigen-uptake-in-gastrointestinal-stromal-tumor
#14
Tom Laurens, Fred Witjes, Marcel Janssen, Uta Flucke, Martin Gottardt
A 62-year-old man with recently diagnosed prostatic adenocarcinoma was referred for a whole-body Ga-prostate-specific membrane antigen (PSMA) PET/CT scan for staging. Although the scan did not reveal metastatic disease, it did reveal a PSMA-avid lesion in the upper abdomen located between the liver and the stomach. Histopathologic examination demonstrated a gastrointestinal stromal tumor. The lesion demonstrated increased uptake in the margins of the tumor with a central photopenic area, which we consider to be the typical pattern on PSMA images of a gastrointestinal stromal tumor, based on theoretical PSMA distribution in such a tumor and other reported cases...
January 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29163955/extra-osseous-99m-tc-methylene-diphosphonate-uptake-detected-enlargement-of-the-knee-joint-in-patient-with-polyarthritis
#15
Maria Grazia Caprio, Mariarosaria Manganelli, Simona Limone, Massimiliano Sorbillo, Mario Quarantelli, Alberto Cuocolo, Ciro Gabriele Mainolfi
Bone scintigraphy is a nuclear scanning test used to find abnormalities in the skeleton. Certain abnormal processes involving soft tissues can also cause skeletal accumulation of radiotracer during bone scintigraphy. We present a case of periarticular knee soft tissue (99m)Tc methylene diphosphonate uptake in a patient with asymmetric polyarthritis. A 33-year-old patient with asymmetric polyarthritis, skin lesions and joint pain underwent bone scintigraphy. Total body examination showed an extra-osseous uptake in periarticular soft tissue of knees joints...
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29159062/evaluation-of-factors-influencing-18f-fet-uptake-in-the-brain
#16
Antoine Verger, Carina Stegmayr, Norbert Galldiks, Axel Van Der Gucht, Philipp Lohmann, Gabriele Stoffels, Nadim J Shah, Gereon R Fink, Simon B Eickhoff, Eric Guedj, Karl-Josef Langen
PET using the amino-acid O-(2-18F-fluoroethyl)-l-tyrosine (18F-FET) is gaining increasing interest for brain tumour management. Semi-quantitative analysis of tracer uptake in brain tumours is based on the standardized uptake value (SUV) and the tumour-to-brain ratio (TBR). The aim of this study was to explore physiological factors that might influence the relationship of SUV of 18F-FET uptake in various brain areas, and thus affect quantification of 18F-FET uptake in brain tumours. Negative 18F-FET PET scans of 107 subjects, showing an inconspicuous brain distribution of 18F-FET, were evaluated retrospectively...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29152772/papillary-architecture-of-the-lingual-surface-in-the-puma-puma-concolor
#17
S Erdoğan, S Villar, H E König, W Pérez
This research presents the first anatomical description of the tongue and lingual papillae of the mountain lion (puma). The tongues of three adult male pumas were used in this study. The tongues were dissected and studied firstly by gross and stereomicroscopy. Samples of each part were processed by study with scanning electron microscopy. The margins of the lingual apex were surrounded by numerous filiform papillae, which had a bulky papillary body and a bifurcated tip. On the dorsal surface of the lingual apex, filiform papillae were remarkably pointed and had many secondary projections, which emerged from the base of the main papilla...
November 19, 2017: Anatomia, Histologia, Embryologia
https://www.readbyqxmd.com/read/29145346/role-of-delayed-time-point-imaging-during-abdominal-and-pelvic-cancer-screening-using-fdg-pet-ct-in-the-general-population
#18
Shotaro Naganawa, Takeharu Yoshikawa, Koichiro Yasaka, Eriko Maeda, Naoto Hayashi, Osamu Abe
Although delayed-time-point imaging is expected to improve the results of [F]-fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT), how examinees will benefit from dual-time-point imaging versus initial-time-point imaging alone, remains unclear. This study investigated the role of delayed-time-point imaging in improving the results of abdominal and pelvic cancer screening using FDG-PET/CT.This retrospective review included 3131 screening results (average subject age: 55.5 years, range: 40-88 years)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144798/pancreas-metastases-from-papillary-thyroid-carcinoma-a-review-of-the-literature
#19
Maja Davidson, Randall J Olsen, April A Ewton, Richard J Robbins
OBJECTIVE: Although loco-regional metastases occur in 5-10% of patients with papillary thyroid cancer (PTC), distant metastases are rare, especially to the pancreas. Here we review the literature regarding metastases to the pancreas from PTC and present an illustrative patient. METHODS: The literature search was performed through www.pubmed.org . The information regarding our illustrative case was obtained from the medical records of our institution. RESULTS: Since 1991, 11 cases of pancreas metastases of PTC have been reported...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29143283/evaluation-of-sequential-spect-and-ct-for-targeted-radionuclide-therapy-dosimetry
#20
Tiantian Li, Nien-Yun Wu, Na Song, Greta S P Mok
PURPOSE: In targeted radionuclide therapy (TRT), a prior knowledge of the absorbed dose biodistribution is essential for pre-therapy treatment planning. Previously, we showed that non-rigid organ-by-organ registration in sequential quantitative SPECT images improved dose estimation. This study aims to investigate if sequential CT can further improve TRT dosimetric accuracy. METHODS: We simulated SPECT/CT acquisitions at 1, 12, 24, 72 and 144 h In-111 Zevalin post-injection using an analytical MEGP projector, modeling attenuation, scatter and collimator-detector response...
November 15, 2017: Annals of Nuclear Medicine
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