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https://www.readbyqxmd.com/read/28636866/prevalence-and-risk-factors-of-chlamydia-trachomatis-neisseria-gonorrhoeae-trichomonas-vaginalis-and-other-sexually-transmissible-infections-among-women-attending-antenatal-clinics-in-three-provinces-in-papua-new-guinea-a-cross-sectional-survey
#1
Lisa M Vallely, Pamela Toliman, Claire Ryan, Glennis Rai, Johanna Wapling, Carolyn Tomado, Savarina Huliafi, Gloria Munnull, Patricia Rarau, Suparat Phuanukoonnon, Handan Wand, Peter Siba, Glen D L Mola, John M Kaldor, Andrew J Vallely
Background Papua New Guinea (PNG) is estimated to have among the highest prevalences of HIV and sexually transmissible infections (STIs) of any Asia-Pacific country, and one of the highest burdens of maternal syphilis globally. The prevalence of curable STIs, such as Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV), among pregnant women in PNG is relatively unknown. METHODS: A cross-sectional bio-behavioural survey to investigate the epidemiology of CT, NG, TV and other STIs among pregnant women in three provinces of PNG was undertaken...
October 2016: Sexual Health
https://www.readbyqxmd.com/read/28635678/evaluation-of-classifier-performance-for-multiclass-phenotype-discrimination-in-untargeted-metabolomics
#2
Patrick J Trainor, Andrew P DeFilippis, Shesh N Rai
Statistical classification is a critical component of utilizing metabolomics data for examining the molecular determinants of phenotypes. Despite this, a comprehensive and rigorous evaluation of the accuracy of classification techniques for phenotype discrimination given metabolomics data has not been conducted. We conducted such an evaluation using both simulated and real metabolomics datasets, comparing Partial Least Squares-Discriminant Analysis (PLS-DA), Sparse PLS-DA, Random Forests, Support Vector Machines (SVM), Artificial Neural Network, k-Nearest Neighbors (k-NN), and Naïve Bayes classification techniques for discrimination...
June 21, 2017: Metabolites
https://www.readbyqxmd.com/read/28635560/sorafenib-in-japanese-patients-with-locally-advanced-or-metastatic-medullary-thyroid-carcinoma-and-anaplastic-thyroid-carcinoma
#3
Yasuhiro Ito, Naoyoshi Onoda, Ken-Ichi Ito, Iwao Sugitani, Shunji Takahashi, Iku Yamaguchi, Koki Kabu, Katsuya Tsukada
BACKGROUND: Therapeutic options for treating advanced or metastatic medullary thyroid carcinoma (MTC) and anaplastic thyroid carcinoma (ATC) are still limited in Japan even though vandetanib for MTC, and lenvatinib for MTC and ATC have been approved. Sorafenib is an oral multikinase inhibitor approved for the treatment of patients with radioactive iodine-refractory (RAI-R) differentiated thyroid cancer (DTC). We conducted an uncontrolled, open-label, multicenter, single-arm, phase 2 clinical study to evaluate the safety and efficacy of sorafenib in Japanese patients with MTC and ATC...
June 21, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28635539/an-old-challenge-with-new-promises-a-systematic-review-on-comprehensive-geriatric-assessment-in-long-term-care-facilities
#4
Francesco Panza, Vincenzo Solfrizzi, Madia Lozupone, Maria Rosaria Barulli, Francesca D'Urso, Roberta Stallone, Vittorio Dibello, Alessia Noia, Cristina Di Dio, Antonio Daniele, Antonello Bellomo, Davide Seripa, Antonio Greco, Giancarlo Logroscino
Comprehensive geriatric assessment (CGA) is a multidimensional and multidisciplinary diagnostic process focused on determining the clinical profile, pathological risk, residual skills, short- and long-term prognosis, and the personalized therapeutic and care plan of the functionally compromised and frail older subjects. Previous evidence suggested that the effectiveness of CGA programs may be influenced by the settings where the CGA is performed [i.e., hospital, post-hospital discharge/ long-term care facilities (LTCF), or community/home] as well as the specific clinical conditions of older frail individuals...
June 21, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28633433/the-international-society-for-computational-biology-and-wikiproject-computational-biology-celebrating-ten-years-of-collaboration-towards-open-access
#5
Kieran O'Neill, Vivek Rai, Alastair M Kilpatrick
No abstract text is available yet for this article.
June 19, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28632201/advantageous-developmental-outcomes-of-advancing-paternal-age
#6
M Janecka, F Rijsdijk, D Rai, A Modabbernia, A Reichenberg
Advanced paternal age (APA) at conception has been associated with negative outcomes in offspring, raising concerns about increasing age at fatherhood. Evidence from evolutionary and psychological research, however, suggests possible link between APA and a phenotypic advantage. We defined such advantage as educational success, which is positively associated with future socioeconomic status. We hypothesised that high IQ, strong focus on the subject of interest and little concern about 'fitting in' will be associated with such success...
June 20, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28629938/poly-glycidyl-methacrylate-nanoparticle-coated-capillary-with-oriented-antibody-immobilization-for-immunoaffinity-in-tube-solid-phase-microextraction-preparation-and-characterization
#7
Ling-Ling Ying, Yuan-Chun Ma, Bei Xu, Xian-Hua Wang, Lin-Yi Dong, Dong-Mei Wang, Kun Liu, Liang Xu
A combination between modification with nanoparticles (NP) and oriented antibody immobilization (OAI) on the inner face of capillary was for the first time developed for immunoaffinity in-tube solid-phase microextraction (SPME) to promise high antigen extraction capacity. β2-microglobin (β2MG) and cystatin C (Cys-C) were selected as model antigens. Poly(glycidyl methacrylate) (PGMA) NPs were chemically immobilized onto the capillary by a ring-opening reaction. Antibodies for β2MG and Cys-C were immobilized on the NPs through OAI...
June 12, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28627206/investigation-on-the-endemic-characteristics-of-metorchis-orientalisin-huainan-area-china
#8
Xiaodong Zhan, Chaopin Li, Hua Wu, Entao Sun, Yuxia Zhu
OBJECTIVE: To investigate the endemic characteristics of Metorchis orientalis (M. orientalis)in the Huainan area, Anhui province, China. METHODS: The first-intermediate host, second-intermediate host and reservoir hosts were collected, and the endemic characteristics of M. orientalis were examined through field investigation and artificial infection. RESULTS: Investigation was completed in 89 domestic ducks, 156 domestic chicken, 41 domestic geese, 20 domestic cats and 19 dogs...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28625181/when-sterile-processing-goes-down-an-economic-analysis-of-alternative-strategies-for-supporting-the-service
#9
Susan E Mittenzwei, Jeannie L Topkoff, Mary T Bessesen, Clifford A Porter, Gurdev S Rai, Westyn Branch-Elliman
Given steam-quality challenges at our facility, the financial impact of options for reopening the sterile processing service unit were explored; duration of closure was the major driver of costs. Other potential negative effects of operating-room shutdowns include injury to facility reputation, loss of staff, loss of reimbursements, and harm to residency programs. Infect Control Hosp Epidemiol 2017;1-3.
June 19, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28623332/interaction-of-the-antimicrobial-peptide-aurein-1-2-and-charged-lipid-bilayer
#10
Durgesh K Rai, Shuo Qian
Aurein 1.2 is a potent antimicrobial peptide secreted by frog Litoria aurea. As a short membrane-active peptide with only 13 amino acids in sequence, it has been found to be residing on the surface of lipid bilayer and permeabilizing bacterial membranes at high concentration. However, the detail at the molecular level is largely unknown. In this study, we investigated the action of Aurein 1.2 in charged lipid bilayers composed of DMPC/DMPG. Oriented Circular Dichroism results showed that the peptide was on the surface of lipid bilayer regardless of the charged lipid ratio...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28621293/yield-of-endoscopic-ultrasound-guided-fine-needle-aspiration-for-subcentimetric-lymph-nodes-a-comparison-to-larger-nodes
#11
Narendra S Choudhary, Vijay Bodh, Naveen Kumar, Rajesh Puri, Haimanti Sarin, Mridula Guleria, Tarun Piplani, Sonal Krishan, Rahul Rai, Randhir Sud
BACKGROUND AND OBJECTIVES: Subcentimetric (defined as <1 cm at short axis) lymph nodes are considered benign and there is limited literature on the results of fine needle aspiration (FNA) of these nodes. METHODS: Endoscopic ultrasound (EUS) guided FNA was done on 189 lymph nodes in 166 patients with pyrexia of unknown origin (n = 113) or malignancy (n = 53). Subcentimetric lymph nodes (Group A) were compared to nodes with short axis diameter ≥1 cm (Group B)...
May 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/28620431/a-44-year-old-caucasian-male-nonsmoker-with-worsening-difficulty-in-breathing-and-decreased-exercise-tolerance
#12
Sunita Rai, Alina Andreea Ionescu
Can you diagnose this patient and identify the uncommon cause of his illness? http://ow.ly/t4nX30bzJFz.
June 2017: Breathe
https://www.readbyqxmd.com/read/28619005/effects-of-immunonutrition-on-biomarkers-in-traumatic-brain-injury-patients-in-malaysia-a-prospective-randomized-controlled-trial
#13
Vineya Rai Hakumat Rai, Lee Fern Phang, Sheau Fung Sia, Amirah Amir, Jeyaganesh S Veerakumaran, Mustafa Kassim Abdulazez Kassim, Rafidah Othman, Pei Chien Tah, Pui San Loh, Mohamad Irfan Othman Jailani, Gracie Ong
BACKGROUND: Head injury is one of the top three diagnosis leading to intensive care unit (ICU) admission in Malaysia. There has been growing interest in using immunonutrition as a mode of modulating the inflammatory response to injury or infection with the aim of improving clinical outcome. The aim of the present study was to evaluate the effect of an immunonutrition on biomarkers (IL-6, glutathione, CRP, total protein and albumin) in traumatic brain injury patients. METHODS: Thirty six patients with head injury admitted to neurosurgical ICU in University Malaya Medical Centre were recruited for this study, over a 6-month period from July 2014 to January 2015...
June 15, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28617194/impact-of-online-toxicology-training-on-health-professionals-the-global-educational-toxicology-uniting-project-getup
#14
Anselm Wong, Rais Vohra, Andrew H Dawson, Andrew Stolbach
OBJECTIVE: The Global Educational Toxicology Uniting Project (GETUP), supported by the American College of Medical Toxicology, links countries with and without toxicology services via distance education with the aim to improve education. Due to the lack of toxicology services in some countries there is a knowledge gap in the management of poisonings. We describe our experience with the worldwide delivery of an online introductory toxicology curriculum to emergency doctors and other health professionals treating poisoned patients...
June 15, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28616771/androgen-supplementation-improves-some-but-not-all-aspects-of-immune-senescence-in-aged-male-macaques
#15
Maham Rais, Randall M Wilson, Henryk F Urbanski, Ilhem Messaoudi
Aging leads to a progressive decline in immune function commonly referred to as immune senescence, which results in increased incidence and severity of infection. In addition, older males experience a significant disruption in their levels of circulating androgens, notably testosterone and dehydroepiandrosterone (DHEA), which has been linked to sarcopenia, osteoporosis, cardiovascular disease, and diabetes. Since sex steroid levels modulate immune function, it is possible that the age-related decline in androgen levels can also affect immune senescence...
June 14, 2017: GeroScience
https://www.readbyqxmd.com/read/28615927/p-tsa-promoted-syntheses-of-5h-benzo-h-thiazolo-2-3-b-quinazoline-and-indeno-1-2-d-thiazolo-3-2-a-pyrimidine-analogs-molecular-modeling-and-in-vitro-antitumor-activity-against-hepatocellular-carcinoma
#16
Amit K Keshari, Ashok K Singh, Vinit Raj, Amit Rai, Prakruti Trivedi, Balaram Ghosh, Umesh Kumar, Atul Rawat, Dinesh Kumar, Sudipta Saha
In our efforts to address the rising incidence of hepatocellular carcinoma (HCC), we have made a commitment to the synthesis of novel molecules to combat Hep-G2 cells. A facile and highly efficient one-pot, multicomponent reaction has been successfully devised utilizing a p-toluenesulfonic acid (p-TSA)-catalyzed domino Knoevenagel/Michael/intramolecular cyclization approach for the synthesis of novel 5H-benzo[h]thiazolo[2,3-b]quinazoline and indeno[1,2-d] thiazolo[3,2-a]pyrimidine analogs bearing a bridgehead nitrogen atom...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28615043/-like-sugar-in-milk-reconstructing-the-genetic-history-of-the-parsi-population
#17
Gyaneshwer Chaubey, Qasim Ayub, Niraj Rai, Satya Prakash, Veena Mushrif-Tripathy, Massimo Mezzavilla, Ajai Kumar Pathak, Rakesh Tamang, Sadaf Firasat, Maere Reidla, Monika Karmin, Deepa Selvi Rani, Alla G Reddy, Jüri Parik, Ene Metspalu, Siiri Rootsi, Kurush Dalal, Shagufta Khaliq, Syed Qasim Mehdi, Lalji Singh, Mait Metspalu, Toomas Kivisild, Chris Tyler-Smith, Richard Villems, Kumarasamy Thangaraj
BACKGROUND: The Parsis are one of the smallest religious communities in the world. To understand the population structure and demographic history of this group in detail, we analyzed Indian and Pakistani Parsi populations using high-resolution genetic variation data on autosomal and uniparental loci (Y-chromosomal and mitochondrial DNA). Additionally, we also assayed mitochondrial DNA polymorphisms among ancient Parsi DNA samples excavated from Sanjan, in present day Gujarat, the place of their original settlement in India...
June 14, 2017: Genome Biology
https://www.readbyqxmd.com/read/28613121/experiences-in-running-a-complex-electronic-data-capture-system-using-mobile-phones-in-a-large-scale-population-trial-in-southern-nepal
#18
Sarah Style, B James Beard, Helen Harris-Fry, Aman Sengupta, Sonali Jha, Bhim P Shrestha, Anjana Rai, Vikas Paudel, Meelan Thondoo, Anni-Maria Pulkki-Brannstrom, Jolene Skordis-Worrall, Dharma S Manandhar, Anthony Costello, Naomi M Saville
The increasing availability and capabilities of mobile phones make them a feasible means of data collection. Electronic Data Capture (EDC) systems have been used widely for public health monitoring and surveillance activities, but documentation of their use in complicated research studies requiring multiple systems is limited. This paper shares our experiences of designing and implementing a complex multi-component EDC system for a community-based four-armed cluster-Randomised Controlled Trial in the rural plains of Nepal, to help other researchers planning to use EDC for complex studies in low-income settings...
2017: Global Health Action
https://www.readbyqxmd.com/read/28612608/higher-antioxidant-activity-total-flavonols-and-specific-quercetin-glucosides-in-two-different-onion-allium-cepa-l-varieties-grown-under-organic-production-results-from-a-6-year-field-study
#19
Feiyue Ren, Kim Reilly, Joseph P Kerry, Michael Gaffney, Mohammad Hossain, Dilip K Rai
We carried out a 6-year study to assess the effect of conventional, organic, and mixed cultivation practices on bioactive compounds (flavonoids, anthocyanins) and antioxidant capacity in onion. Total flavonoids, total anthocyanins, individual flavonols, individual anthocyanins, and antioxidant activity were measured in two varieties ('Hyskin' and 'Red Baron') grown in a long-term split-plot factorial systems comparison trial. This is the first report of repeated measurements of bioactive content over an extensive time period in a single crop type within the same trial...
June 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28612178/treatment-for-depression-and-health-related-quality-of-life-among-adults-with-arthritis
#20
Drishti Shah, Pragya Rai, Nilanjana Dwibedi, Usha Sambamoorthi
Depression treatment has been proven to relieve depressive symptoms and pain and may therefore improve the health-related quality of life (HRQoL) among adults with arthritis. The objective of the current study was to examine the HRQoL associated with depression treatment among adults with arthritis and depression. A retrospective longitudinal cohort study design using data from the Medical Expenditure Panel Survey (2009-2012) was adopted. The study sample consisted of adults (≥ 21 years) with co-existing arthritis and depression (N = 1692)...
June 13, 2017: Psychiatric Quarterly
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