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https://www.readbyqxmd.com/read/28812885/ecological-risk-assessment-of-nano-enabled-pesticides-a-perspective-on-problem-formulation
#1
Glen W Walker, Rai S Kookana, Natalie E Smith, Melanie Kah, Casey Doolette, Philip Reeves, Wess Lovell, Darren J Anderson, Terence W Turney, Divina A Navarro
Plant protection products containing nanomaterials that alter the functionality or risk profile of active ingredients (nano-enabled pesticides) promise many benefits over conventional pesticide products. These benefits may include improved formulation characteristics, easier application, better targeting of pest species, increased efficacy, lower application rates, and enhanced environmental safety. After many years of research and development, nano-enabled pesticides are starting to make their way onto the market...
August 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28811919/trainee-experiences-of-intellectual-disability-psychiatry-and-an-innovative-leaderless-support-group-a-qualitative-study
#2
Ross Spackman, Hannah Toogood, Jayne Kerridge, Jon Nash, Elizabeth Anderson, Dheeraj Rai
Aims and method There is very little research into the challenges of training in intellectual disability psychiatry or into interventions which may address these challenges. Using focus groups, we explored the experiences of intellectual disability psychiatry trainees, and evaluated a leaderless trainee support group developed in Bristol. Results Five distinct themes were identified via framework analysis: that trainees felt unprepared for the difference from previous posts; the need for support; the value of the group; that trainees were concerned about judgement in supervision; that the group structure was valued...
August 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/28811683/methylenetetrahydrofolate-reductase-c677t-polymorphism-and-risk-for-male-infertility-in-asian-population
#3
Vandana Rai, Pradeep Kumar
Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme of folate pathway and required for DNA synthesis and methylation. MTHFE C677T polymorphisms is reported as risk factors for various diseases and disorders like birth defects, metabolic, neurological, psychiatric disorders, and cancers. Several studies have investigated association between the MTHFR C677T polymorphism and male infertility. To assess the risk associated with MTHFR C677T polymorphism in Asian population, a meta-analysis was performed...
July 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28806547/environmental-life-cycle-assessment-of-seafood-production-a-case-study-of-trawler-catches-in-tunisia
#4
Khaled Abdou, Didier Gascuel, Joël Aubin, Mohamed Salah Romdhane, Frida Ben Rais Lasram, François Le Loc'h
The Gulf of Gabes is one of the most productive fishery areas in the southern Mediterranean Sea. It is archetypal of an ecosystem in which the effects of fisheries are most pronounced. Demersal trawling is the main fishing activity in the Gulf of Gabes. Life Cycle Assessment (LCA) was applied to assess the environmental performance landing 1t of seafood with wooden demersal trawlers in the Gulf of Gabes. Impact categories included in the study were abiotic depletion potential (ADP), acidification potential (AP), eutrophication potential (EP), global warming potential (GWP), ozone depletion potential (ODP), photochemical oxidant formation potential (POFP), human toxicity potential (HTP), marine eco-toxicity potential (METP), terrestrial eco-toxicity potential (TETP), land occupation potential (LOP), and total cumulative energy demand (TCED)...
August 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28805380/evaluating-the-antibacterial-properties-of-polyacetylene-and-glucosinolate-compounds-with-further-identification-of-their-presence-within-various-carrot-daucus-carota-and-broccoli-brassica-oleracea-cultivars-using-high-performance-liquid-chromatography-with
#5
L Hinds, O Kenny, M B Hossain, D Walsh, E Sheehy, P Evans, M Gaffney, D K Rai
Ongoing consumer concerns over using synthetic additives in foods has strongly influenced efforts worldwide to source suitable natural alternatives. In this study, the antibacterial efficacy of polyacetylene and glucosinolate compounds was evaluated against both Gram positive and Gram negative bacterial strains. Falcarinol [minimum inhibitory concentration (MIC) = 18.8-37.6 μg/mL] demonstrated the best overall antibacterial activity, while sinigrin (MIC = 46.9-62.5 μg/mL) was the most active glucosinolate compound...
August 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28805135/intermittent-dosing-of-dabrafenib-and-trametinib-in-metastatic-brafv600e-mutated-papillary-thyroid-cancer-two-case-reports
#6
Paul S White, Anita Pudusseri, Stephanie L Lee, Omar Eton
BACKGROUND: A multi-institutional randomized Phase II trial of continuous dosing of dabrafenib with or without trametinib is ongoing in metastatic thyroid cancer. Preclinical evidence and emerging clinical experience in other cancers support evaluating intermittent dosing of these two agents to achieve more durable response, while being better tolerated and more cost effective. PATIENTS: Two consecutive patients with symptomatic, metastatic radioactive iodine (RAI) resistant BRAF V600E mutated papillary thyroid cancer and poor performance status were treated initially with dabrafenib 150mg twice daily plus trametinib 2mg once daily, first in continuous daily dosing, then in a five-week-on and three-week-off schedule...
August 12, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28805100/older-adults-with-a-combination-of-vision-and-hearing-impairment-experience-higher-rates-of-cognitive-impairment-functional-dependence-and-worse-outcomes-across-a-set-of-quality-indicators
#7
Jacob G S Davidson, Dawn M Guthrie
OBJECTIVES: Hearing and vision impairment were examined across several health-related outcomes and across a set of quality indicators (QIs) in home care clients with both vision and hearing loss (or dual sensory impairment [DSI]). METHOD: Data collected using the Resident Assessment Instrument for Home Care (RAI-HC) were analyzed in a sample of older home care clients. The QIs represent the proportion of clients experiencing negative outcomes (e.g., falls, social isolation)...
August 1, 2017: Journal of Aging and Health
https://www.readbyqxmd.com/read/28804992/gold-catalyzed-4-2-annulation-cyclization-cascades-of-benzisoxazoles-with-propiolate-derivatives-to-access-highly-oxygenated-tetrahydroquinolines
#8
Rajkumar Lalji Sahani, Rai-Shung Liu
This work describes gold-catalyzed annulations of electron-deficient alkynes with benzisoxazoles to yield quinoline oxides chemoselectively. Chemical functionalizations of these resulting azacyclic compounds afforded various oxygenated tetrahydroquinolines that are present as the cores of many bioactive molecules. With the same reactants, a new relay catalysis using gold and Zn(II) catalysts affords highly oxygenated tetrahydroquinoline derivatives stereoselectively.
August 13, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28803058/survey-of-ferns-and-clinico-pathological-studies-on-the-field-cases-of-enzootic-bovine-haematuria-in-himachal-pradesh-a-north-western-himalayan-state-of-india
#9
Sarvesh K Rai, Rinku Sharma, Alka Kumari, Lars H Rasmussen, Rajendra D Patil, Rasbehari Bhar
Enzootic bovine haematuria (EBH) in cattle occurs in upland areas of the world. In India, the disease is present in isolated pockets in the Himalayas and in the Nilgiri Hills. The variation in the disease incidence has been attributed to different environmental conditions and animal rearing practices followed in the different regions. The aim of the study was to conduct field surveys in parts of EBH endemic regions of Himachal Pradesh, a north-western Himalayan state of India. Out of the total 103 plant samples collected, a total of 95 samples were identified as ferns...
August 9, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28802663/peripheral-gamma-delta-t-cells-secrete-inflammatory-cytokines-in-women-with-idiopathic-recurrent-pregnancy-loss
#10
Ayantika Talukdar, Reeta Rai, K Aparna Sharma, D N Rao, Alpana Sharma
BACKGROUND: Gamma delta (γδ) T cells are known to link innate and adaptive immunity. Decidual γδ T cells are known to provide immunotolerance by producing IL-10 and TGF-β. In recurrent pregnancy loss (RPL) females, the role of peripheral γδ T cells remain unstudied. OBJECTIVE: To investigate the different phenotypes of γδ T cells in the peripheral blood of women with idiopathic RPL and their possible involvement in RPL condition. METHODS: A total of 120 women were recruited for the study...
August 9, 2017: Cytokine
https://www.readbyqxmd.com/read/28802067/crh-stimulation-tests-for-the-infants-with-relative-adrenal-insufficiency
#11
Kougoro Iwanaga, Akane Yamamoto, Takashi Matsukura, Fusako Niwa, Masahiko Kawai
BACKGROUND: Very low birth weight (VLBW) infants are considered to be vulnerable to relative adrenal insufficiency (RAI); however, diagnosis is difficult in some clinical settings. Considering this background, it is necessary to establish a diagnosis of RAI in preterm infants. OBJECTIVE: In this study, we attempted to clarify the difference in response to CRH stimulation tests for preterm infants with or without RAI. METHODS: Between June 2009 and December 2015, we performed CRH stimulation tests for preterm infants born at a gestational age of <30 weeks at around two weeks of age...
August 12, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28801384/causes-of-and-contributors-to-infant-mortality-in-a-rural-community-of-north-india-evidence-from-verbal-and-social-autopsy
#12
Sanjay Kumar Rai, Shashi Kant, Rahul Srivastava, Priti Gupta, Puneet Misra, Chandrakant Sambhaji Pandav, Arvind Kumar Singh
OBJECTIVE: To identify the medical causes of death and contribution of non-biological factors towards infant mortality by a retrospective analysis of routinely collected data using verbal and social autopsy tools. SETTING: The study site was Health and Demographic Surveillance System (HDSS), Ballabgarh, North India PARTICIPANTS: All infant deaths during the years 2008-2012 were included for verbal autopsy and infant deaths from July 2012 to December 2012 were included for social autopsy...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801184/fatal-colloid-cysts-a-systematic-review
#13
REVIEW
Carlito Lagman, Kanwaldeep Rai, Lawrance K Chung, Daniel T Nagasawa, Joel S Beckett, Alexander M Tucker, Isaac Yang
OBJECTIVE: To accurately characterize patient characteristics and the clinical presentation of fatal colloid cysts. METHODS: A systematic literature search of three popular databases was performed. Inclusion criteria were individuals with sudden-onset death and colloid cysts identified on imaging and/or autopsy. The cause of death must have been ascribed to the colloid cyst. Deaths precipitated by lumbar puncture were excluded. Clinical data were extracted and descriptive statistics were ascertained...
August 8, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28800633/feeding-fasting-dependent-recruitment-of-membrane-microdomain-proteins-to-lipid-droplets-purified-from-the-liver
#14
Kritika Sadh, Priyanka Rai, Roop Mallik
Lipid droplets (LDs) are cellular stores of neutral fat that facilitate lipid and protein trafficking in response to metabolic cues. Unlike other vesicles, the phospholipid membrane on the LD is a monolayer. Interestingly, this monolayer membrane has free cholesterol, and may therefore contain lipid microdomains that serve as a platform for assembling proteins involved in signal transduction, cell polarity, pathogen entry etc. In support of this, cell culture studies have detected microdomain-associated "raftophilic" proteins on LDs...
2017: PloS One
https://www.readbyqxmd.com/read/28800616/seroprevalence-of-iga-anti-epstein-barr-virus-is-high-among-family-members-of-nasopharyngeal-cancer-patients-and-individuals-presenting-with-chronic-complaints-in-head-and-neck-area
#15
Susanna Hilda Hutajulu, Jajah Fachiroh, Gabriella Argy, Sagung Rai Indrasari, Luh Putu Lusy Indrawati, Dewi Kartikawati Paramita, Theodola Baning Rahayu Jati, Jaap M Middeldorp
Epstein-Barr (EBV) infection and presence of a nasopharyngeal cancer (NPC) case in the family increases the risk of developing NPC. Aberrant anti-EBV immunoglobulin A (IgA) antibodies (EBV-IgA) may be present in the sera of non-cancer individuals and predict NPC. Limited studies report the presence of EBV-IgA antibodies within non-cancer individuals in Indonesia where the disease is prevalent. This study aimed at exploring whether EBV-IgA was found more frequently among first degree relatives of NPC patients and individuals presenting with chronic symptoms in the head and neck area compared to healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/28799540/corrigendum-understanding-cancer-complexome-using-networks-spectral-graph-theory-and-multilayer-framework
#16
Aparna Rai, Priodyuti Pradhan, Jyothi Nagraj, K Lohitesh, Rajdeep Chowdhury, Sarika Jalan
No abstract text is available yet for this article.
May 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28799022/early-vs-standard-unclamping-technique-in-minimal-access-partial-nephrectomy-a-meta-analysis-of-observational-cohort-studies-and-the-lister-cohort
#17
REVIEW
Thomas Stonier, Bhavan Prasad Rai, Mariele Trimboli, Ahmed Abroaf, Amit Patel, S Gowrie-Mohan, Venkat Prasad, Nikhil Vasdev, Jim Adshead
To evaluate if early unclamping (EUC) of the renal pedicle compromises perioperative outcomes in minimally invasive partial nephrectomy (PN). The cohort study includes all robot-assisted PN performed between September 2012 and September 2015 by a single surgeon at the Lister Hospital, Stevenage, UK. The systematic review and meta-analysis was performed according to the PRISMA guidelines identifying studies comparing EUC and standard unclamping (SUC) in either laparoscopic or robot-assisted PN. The Lister cohort prospectively reported 84 cases of robot-assisted PN (SUC = 22, EUC = 62) with a mean age of 58 years (SD = 11)...
August 10, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28791691/birth-rates-after-radioactive-iodine-treatment-for-differentiated-thyroid-cancer
#18
Chelsea Anderson, Stephanie M Engel, Mark A Weaver, Jose P Zevallos, Hazel B Nichols
Treatment with radioactive iodine (RAI) for differentiated thyroid cancer has been associated with alterations in gonadal function in women, including changes in menstrual function and an earlier age at menopause. Our objective was to evaluate associations between RAI and post-diagnosis live birth rates among thyroid cancer survivors diagnosed at ages 15-39 years. We identified women diagnosed with differentiated thyroid cancer between January 2000 and December 2013 in the North Carolina Central Cancer Registry (CCR)...
August 9, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28791593/key-pharmacokinetic-essentials-of-fixed-dosed-combination-products-case-studies-and-perspectives
#19
Ranjeet Prasad Dash, Rana Rais, Nuggehally R Srinivas
Fixed-dose combinations are gaining popularity because they provide convenience while enhancing patient compliance. Literature examples suggest that many fixed-dose combinations are being rationalized and investigated for their potential utility in therapy. This article provides an introspection into the pharmacokinetic essentials that need to be considered prior to implementing a fixed-dose combination strategy. While the drug-drug interaction potential is an important question for the two drugs in a fixed-dose combination, the occurrence of a drug-drug interaction in itself is not a negative outcome for the proposed fixed-dose combination...
August 8, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28791246/etiologies-and-posttreatment-conditions-of-thyrotoxic-patients-in-sylhet-division-bangladesh-a-clinical-series
#20
Md Kayes Mahmud, Shahnaz Jalil, Ahm Mahmudur Rahman, Md Mamun-Ur Rashid, Shiny Sultana, Adnan Taher, Lutful Haque, Jannatul Fardous, Kamrun Nahar
OBJECTIVE: The endeavor of the study was to analyze the posttreatment (postradioactive iodine therapy [RAI]) conditions of thyrotoxic patients in a tertiary level hospital. MATERIALS AND METHODS: A retrospective study of 186 patients was conducted from 2012 to 2014 in Institute of Nuclear Medicine and Allied Sciences (INMAS), Sylhet MAG Osmani Medical College Campus. Patients' information regarding the etiologies and their disease status after getting RAI therapy was recorded...
July 2017: Avicenna Journal of Medicine
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