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https://www.readbyqxmd.com/read/28678059/peripheral-interventions-for-painful-stump-neuromas-of-the-lower-limb-a-systematic-review
#1
Stephanie Alexandra Poyntz, Milind Dalal, Nicholas Hacking, Stephen Fowler
OBJECTIVES: Painful stump neuromas in lower limb amputees are a significant burden on a person's quality of life due to interference with wearing prostheses and therefore the ability to walk. Treating painful stump neuromas is a challenge perhaps reflected by the lack of clinical guidelines both in the United Kingdom and internationally. METHODS: A systematic review was conducted to evaluate the efficacy of all treatments tried in the management of symptomatic neuromas in the lower limb amputation stump in order to establish whether one treatment is superior...
July 3, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28657423/in-vitro-metabolism-of-alectinib-a-novel-potent-alk-inhibitor-in-human-contribution-of-cyp3a-enzymes
#2
Toshito Nakagawa, Stephen Fowler, Kenji Takanashi, Kuresh Youdim, Tsuyoshi Yamauchi, Kosuke Kawashima, Mika Sato-Nakai, Li Yu, Masaki Ishigai
1. The in vitro metabolism of alectinib, a potent and highly selective oral anaplastic lymphoma kinase inhibitor, was investigated. 2. The main metabolite (M4) in primary human hepatocytes was identified, which is produced by deethylation at the morpholine ring. Three minor metabolites (M6, M1a, and M1b) were also identified, and a minor peak of hydroxylated alectinib (M5) was detected as a possible precursor of M4, M1a, and M1b. 3. M4, an important active major metabolite, was produced and further metabolized to M6 by CYP3A, indicating that CYP3A enzymes were the principal contributors to this route...
July 21, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28611376/allopregnanolone-mediates-the-exacerbation-of-tourette-like-responses-by-acute-stress-in-mouse-models
#3
Laura J Mosher, Sean C Godar, Marianela Nelson, Stephen C Fowler, Graziano Pinna, Marco Bortolato
Tourette syndrome (TS) is a neuropsychiatric disorder characterized by multiple tics and sensorimotor abnormalities, the severity of which is typically increased by stress. The neurobiological underpinnings of this exacerbation, however, remain elusive. We recently reported that spatial confinement (SC), a moderate environmental stressor, increases tic-like responses and elicits TS-like sensorimotor gating deficits in the D1CT-7 mouse, one of the best-validated models of TS. Here, we hypothesized that these adverse effects may be mediated by neurosteroids, given their well-documented role in stress-response orchestration...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28565802/continuous-type-splenogonadal-fusion-a-case-report
#4
Guizhen Huang, Yidong Huang, Li Zeng, Miao Yuan, Yang Wu, Lugang Huang
Splenogonadal fusion (SGF) is a rare congenital malformation. Since it lacks characteristic features, very few cases of SGF have been diagnosed preoperatively. Laparoscopy was effective in both diagnosing and surgically treating this condition. Herein, we reported left side SGF in a male patient who was diagnosed during laparoscopic exploration, and Fowler-Stephens orchidopexy was implemented at the same time. The patient was followed up for one year. At a 6-month follow-up, the left scrotum demonstrated swelling and the internal contents were hard...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28461291/perspectives-of-patients-and-healthcare-professionals-on-mhealth-for-asthma-self-management
#5
Andrew J Simpson, Persijn J Honkoop, Erika Kennington, Jiska B Snoeck-Stroband, Ian Smith, Jessica East, Courtney Coleman, Ann Caress, Kian Fan Chung, Jacob K Sont, Omar Usmani, Stephen J Fowler
Mobile healthcare (mHealth) has the potential to revolutionise the self-management of long-term medical conditions such as asthma. A user-centred design is integral if mHealth is to be embraced by patients and healthcare professionals.The aim of this study was to determine the perspectives of individuals with asthma and healthcare professionals on the use of mHealth for asthma self-management.We used a sequential exploratory mixed methods design; focus groups informed the development of questionnaires, which were disseminated to individuals with asthma and healthcare professionals...
May 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28446552/a-european-respiratory-society-technical-standard-exhaled-biomarkers-in-lung-disease
#6
Ildiko Horváth, Peter J Barnes, Stelios Loukides, Peter J Sterk, Marieann Högman, Anna-Carin Olin, Anton Amann, Balazs Antus, Eugenio Baraldi, Andras Bikov, Agnes W Boots, Lieuwe D Bos, Paul Brinkman, Caterina Bucca, Giovanna E Carpagnano, Massimo Corradi, Simona Cristescu, Johan C de Jongste, Anh-Tuan Dinh-Xuan, Edward Dompeling, Niki Fens, Stephen Fowler, Jens M Hohlfeld, Olaf Holz, Quirijn Jöbsis, Kim Van De Kant, Hugo H Knobel, Konstantinos Kostikas, Lauri Lehtimäki, Jon Lundberg, Paolo Montuschi, Alain Van Muylem, Giorgio Pennazza, Petra Reinhold, Fabio L M Ricciardolo, Philippe Rosias, Marco Santonico, Marc P van der Schee, Frederik-Jan van Schooten, Antonio Spanevello, Thomy Tonia, Teunis J Vink
Breath tests cover the fraction of nitric oxide in expired gas (FeNO), volatile organic compounds (VOCs), variables in exhaled breath condensate (EBC) and other measurements. For EBC and for FeNO, official recommendations for standardised procedures are more than 10 years old and there is none for exhaled VOCs and particles. The aim of this document is to provide technical standards and recommendations for sample collection and analytic approaches and to highlight future research priorities in the field. For EBC and FeNO, new developments and advances in technology have been evaluated in the current document...
April 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28433741/loss-of-the-neurodevelopmental-gene-zswim6-alters-striatal-morphology-and-motor-regulation
#7
David J Tischfield, Dave K Saraswat, Andrew Furash, Stephen C Fowler, Marc V Fuccillo, Stewart A Anderson
The zinc-finger SWIM domain-containing protein 6 (ZSWIM6) is a protein of unknown function that has been associated with schizophrenia and limited educational attainment by three independent genome-wide association studies. Additionally, a putatively causal point mutation in ZSWIM6 has been identified in several cases of acromelic frontonasal dysostosis with severe intellectual disability. Despite the growing number of studies implicating ZSWIM6 as an important regulator of brain development, its role in this process has never been examined...
July 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28412392/diminished-airway-macrophage-expression-of-the-axl-receptor-tyrosine-kinase-is-associated-with-defective-efferocytosis-in-asthma
#8
Aleksander M Grabiec, Nicholas Denny, John A Doherty, Kaisa E Happonen, Jenny Hankinson, Emma Connolly, Mark E Fife, Toshifumi Fujimori, Naoya Fujino, Anu Goenka, Susan Holden, Gaël Tavernier, Rajesh Shah, Peter C Cook, Andrew S MacDonald, Robert M Niven, Björn Dahlbäck, Stephen J Fowler, Angela Simpson, Tracy Hussell
No abstract text is available yet for this article.
April 12, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28410943/efficacy-of-single-stage-and-two-stage-fowler-stephens-laparoscopic-orchidopexy-in-the-treatment-of-intraabdominal-high-testis
#9
Chang-Yuan Wang, Yang Wang, Xiao-Hua Chen, Xiao-Yu Wei, Feng Chen, Min Zhong
BACKGROUND/OBJECTIVE: To compare the curative effect of single-stage and two-stage Fowler-Stephens (F-S) laparoscopic orchidopexy for intraabdominal high testis and explore the appropriate surgical approach. METHODS: We performed a prospective analysis of the clinical data of 28 patients who underwent F-S laparoscopic orchidopexy for intraabdominal high testis in our department from May 2012 to April 2015, including 15 cases of the single-stage F-S operation and 13 cases of the two-stage F-S operation...
April 12, 2017: Asian Journal of Surgery
https://www.readbyqxmd.com/read/28270955/laparoscopic-one-stage-fowler-stephens-orchiopexy-preserving-gubernaculum
#10
Ali Naycı, Gökhan Berktuğ Bahadır, Cankat Erdoğan, Hakan Taşkınlar
OBJECTIVE: To assess gubernaculum-sparing laparoscopic one-stage Fowler-Stephens orchiopexy (FSO), in the management of high intrapelvic testis. MATERIAL AND METHODS: Medical reports of boys who underwent laparoscopic one-stage FSO were retrospectively reviewed. High intrapelvic testis was defined as testis ≥3 cm away from ipsilateral internal ring. Testes were evaluated on physical examination at 3(rd), 6(th) and 18(th) months after surgery. Children were evaluated as for their demographic data, operative findings, interventional details and outcomes...
March 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28261547/progress-in-prediction-and-interpretation-of-clinically-relevant-metabolic-drug-drug-interactions-a-minireview-illustrating-recent-developments-and-current-opportunities
#11
REVIEW
Stephen Fowler, Peter N Morcos, Yumi Cleary, Meret Martin-Facklam, Neil Parrott, Michael Gertz, Li Yu
PURPOSE OF REVIEW: This review gives a perspective on the current "state of the art" in metabolic drug-drug interaction (DDI) prediction. We highlight areas of successful prediction and illustrate progress in areas where limits in scientific knowledge or technologies prevent us from having full confidence. RECENT FINDINGS: Several examples of success are highlighted. Work done for bitopertin shows how in vitro and clinical data can be integrated to give a model-based understanding of pharmacokinetics and drug interactions...
2017: Current Pharmacology Reports
https://www.readbyqxmd.com/read/28239983/targeted-deletion-of-gd3-synthase-protects-against-mptp-induced-neurodegeneration
#12
Y Akkhawattanangkul, P Maiti, Y Xue, D Aryal, W C Wetsel, D Hamilton, S C Fowler, M P McDonald
Parkinson's disease is a debilitating neurodegenerative condition for which there is no cure. Converging evidence implicates gangliosides in the pathogenesis of several neurodegenerative diseases, suggesting a potential new class of therapeutic targets. We have shown that interventions that simultaneously increase the neuroprotective GM1 ganglioside and decrease the pro-apoptotic GD3 ganglioside - such as inhibition of GD3 synthase (GD3S) or administration of sialidase - are neuroprotective in vitro and in a number of preclinical models...
February 27, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28119390/myaircoach-the-use-of-home-monitoring-and-mhealth-systems-to-predict-deterioration-in-asthma-control-and-the-occurrence-of-asthma-exacerbations-study-protocol-of-an-observational-study
#13
Persijn J Honkoop, Andrew Simpson, Matteo Bonini, Jiska B Snoeck-Stroband, Sally Meah, Kian Fan Chung, Omar S Usmani, Stephen Fowler, Jacob K Sont
INTRODUCTION: Asthma is a variable lung condition whereby patients experience periods of controlled and uncontrolled asthma symptoms. Patients who experience prolonged periods of uncontrolled asthma have a higher incidence of exacerbations and increased morbidity and mortality rates. The ability to determine and to predict levels of asthma control and the occurrence of exacerbations is crucial in asthma management. Therefore, we aimed to determine to what extent physiological, behavioural and environmental data, obtained by mobile healthcare (mHealth) and home-monitoring sensors, as well as patient characteristics, can be used to predict episodes of uncontrolled asthma and the onset of asthma exacerbations...
January 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28102831/biomarkers-in-adult-asthma-a-systematic-review-of-8-isoprostane-in-exhaled-breath-condensate
#14
Adam M Peel, Christina-Jane Crossman-Barnes, Jonathan Tang, Stephen J Fowler, Gwyneth A Davies, Andrew M Wilson, Yoon K Loke
OBJECTIVES: We aimed to assess the evidence for the use of 8-isoprostane in exhaled breath condensate (EBC) as a biomarker in adult asthma. DESIGN: A systematic review and meta-analysis of EBC 8-isoprostane. METHODS: We searched a number of online databases (including PubMed, Embase and Scopus) in January 2016. We included studies of adult non-smokers with EBC collection and asthma diagnosis conducted according to recognised guidelines. We aimed to pool data using random effects meta-analysis and assess heterogeneity using I (2)...
February 10, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28099872/assessment-of-gait-and-sensorimotor-deficits-in-the-d1ct-7-mouse-model-of-tourette-syndrome
#15
Stephen C Fowler, Laura J Mosher, Sean C Godar, Marco Bortolato
Tourette syndrome (TS) is a neurodevelopmental disorder characterized by multiple motor and phonic tics. While TS patients have been also shown to exhibit subtle abnormalities of sensorimotor integration and gait, animal models of this disorder are seldom tested for these functions. To fill this gap, we assessed gait and sensorimotor integration in the D1CT-7 mouse, one of the best-validated animal models of TS. D1CT-7 mice exhibit spontaneous tic-like manifestations, which, in line with the clinical phenomenology of TS, are markedly exacerbated by environmental stress...
January 15, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28050713/metabolic-profiling-of-human-long-term-liver-models-and-hepatic-clearance-predictions-from-in-vitro-data-using-nonlinear-mixed-effects-modeling
#16
Nicole A Kratochwil, Christophe Meille, Stephen Fowler, Florian Klammers, Aynur Ekiciler, Birgit Molitor, Sandrine Simon, Isabelle Walter, Claudia McGinnis, Johanna Walther, Brian Leonard, Miriam Triyatni, Hassan Javanbakht, Christoph Funk, Franz Schuler, Thierry Lavé, Neil J Parrott
Early prediction of human clearance is often challenging, in particular for the growing number of low-clearance compounds. Long-term in vitro models have been developed which enable sophisticated hepatic drug disposition studies and improved clearance predictions. Here, the cell line HepG2, iPSC-derived hepatocytes (iCell®), the hepatic stem cell line HepaRG™, and human hepatocyte co-cultures (HμREL™ and HepatoPac®) were compared to primary hepatocyte suspension cultures with respect to their key metabolic activities...
March 2017: AAPS Journal
https://www.readbyqxmd.com/read/28049457/breathdx-molecular-analysis-of-exhaled-breath-as-a-diagnostic-test-for-ventilator-associated-pneumonia-protocol-for-a-european-multicentre-observational-study
#17
Pouline M P van Oort, Tamara Nijsen, Hans Weda, Hugo Knobel, Paul Dark, Timothy Felton, Nicholas J W Rattray, Oluwasola Lawal, Waqar Ahmed, Craig Portsmouth, Peter J Sterk, Marcus J Schultz, Tetyana Zakharkina, Antonio Artigas, Pedro Povoa, Ignacio Martin-Loeches, Stephen J Fowler, Lieuwe D J Bos
BACKGROUND: The diagnosis of ventilator-associated pneumonia (VAP) remains time-consuming and costly, the clinical tools lack specificity and a bedside test to exclude infection in suspected patients is unavailable. Breath contains hundreds to thousands of volatile organic compounds (VOCs) that result from host and microbial metabolism as well as the environment. The present study aims to use breath VOC analysis to develop a model that can discriminate between patients who have positive cultures and who have negative cultures with a high sensitivity...
January 3, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27889491/pramipexole-enhances-disadvantageous-decision-making-lack-of-relation-to-changes-in-phasic-dopamine-release
#18
Romina Pes, Sean C Godar, Andrew T Fox, Lauren M Burgeno, Hunter J Strathman, David P Jarmolowicz, Paola Devoto, Beth Levant, Paul E Phillips, Stephen C Fowler, Marco Bortolato
Pramipexole (PPX) is a high-affinity D2-like dopamine receptor agonist, used in the treatment of Parkinson's disease (PD) and restless leg syndrome. Recent evidence indicates that PPX increases the risk of problem gambling and impulse-control disorders in vulnerable patients. Although the molecular bases of these complications remain unclear, several authors have theorized that PPX may increase risk propensity by activating presynaptic dopamine receptors in the mesolimbic system, resulting in the reduction of dopamine release in the nucleus accumbens (NAcc)...
March 1, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/27867845/current-management-of-non-palpable-testes-a-literature-review-and-clinical-results
#19
REVIEW
Ximena Sepúlveda, Pedro-José López Egaña
Cryptorchidism is a common pathology that occurs in 3% in full term newborns, and it decreases to 0.8-1.2% at 1 year of age. Nearly a 20% of undescended testes are non-palpable. Various surgical treatments have been described, but its management is still controversial. A literature review was made of non-palpable testes, analysing diagnostic tools, treatment and its results. Additionally we reviewed non-palpable testes cases treated in our centre in the last 20 years. Different techniques are described for the management of non-palpable testes; with or without section of the spermatic vessels and/or in 1 or 2 stages...
October 2016: Translational pediatrics
https://www.readbyqxmd.com/read/27845220/staged-fowler-stephens-and-single-stage-laparoscopic-orchiopexy-for-intra-abdominal-testes-is-there-a-difference-a-single-institution-experience
#20
Alireza Alam, Joan C Delto, Ruben Blachman-Braun, George Wayne, Angela G Mittal, Miguel Castellan, Kristin Kozakowski, Andrew Labbie, Rafael Gosalbez
OBJECTIVE: To compare single-stage laparoscopic orchiopexy (SSLO) and staged Fowler-Stephens (SFS) procedures in the management of intra-abdominal undescended testes, and to analyze postoperative atrophy and malpositioning as end points. MATERIALS AND METHODS: A retrospective chart review identified laparoscopic orchiopexy patients with intra-abdominal testes between November 2006 and November 2014. Of 167 patients who had laparoscopic orchiopexy, 73 (85 testes) were identified as having laparoscopic orchiopexy...
November 11, 2016: Urology
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