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Toll like receptors and endometrium cancer

Norathee Buathong, Sutthasinee Poonyachoti, Chatsri Deachapunya
OBJECTIVE: The present study aimed to investigate whether genistein, a potent phytoestrogen mainly found in soybean, modulated the expression of TLRs 2, 3, 4 and 9 proteins in human endometrial epithelial cell line RL95-2 under basal and polyinosinic-polycytidylic acid (poly I: C) stimulated conditions to mimic viral infection. The genistein effects were also compared with 17β-estradiol. MATERIAL AND METHOD: The RL95-2 cells were cultured in the estrogen-deprived media with or without poly I: C 30 min prior to incubation with genistein (10(-7), 10(-6) or 10(-5) M) or 17β-estradiol (10(-9) M) for 48 h...
October 2015: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Mee Young Chang, Courtney Smith, James B DuHadaway, Jennifer R Pyle, Janette Boulden, Alejandro Peralta Soler, Alexander J Muller, Lisa D Laury-Kleintop, George C Prendergast
Indoleamine 2,3-dioxygenase (IDO) modifies adaptive immunity, in part by determining the character of inflammatory responses in the tissue microenvironment. Small molecule inhibitors of IDO are being developed to treat cancer, chronic infections and other diseases, so the systemic effects of IDO disruption on inflammatory phenomena may influence the design and conduct of early phase clinical investigations of this new class of therapeutic agents. Here, we report cardiac and gastrointestinal phenotypes observed in IDO deficient mice that warrant consideration in planned assessments of the safety risks involved in clinical development of IDO inhibitors...
December 15, 2011: Cancer Biology & Therapy
Katie A Ashton, Anthony Proietto, Geoffrey Otton, Ian Symonds, Mark McEvoy, John Attia, Rodney J Scott
BACKGROUND: Endometrial cancer is the most common gynaecological malignancy in women of developed countries. Many risk factors implicated in endometrial cancer trigger inflammatory events; therefore, alterations in immune response may predispose an individual to disease. Toll-like receptors (TLRs) and nucleosome-binding oligomerization domain (NOD) genes are integral to the recognition of pathogens and are highly polymorphic. For these reasons, the aim of the study was to assess the frequency of polymorphic variants in TLR and NOD genes in an Australian endometrial cancer population...
2010: BMC Cancer
B Borghese, D Vaiman, D de Ziegler, C Chapron
Endometriosis is a very frequent and debilitating disease responsible for a considerable socio-economic toll. In spite of that, its pathogenesis remains enigmatic. Endometriosis is hold for a multifactorial pathology resulting from the mixed effects of environmental and genetic factors. To date, few susceptibility factors have been reported, with the exception of some polymorphisms in estrogen and progesterone receptors. Large-scale expressional studies have clearly demonstrated that endometriosis is a hormone-dependant disease, characterized by three main features: (i) inflammation, (ii) excessive production of estrogens, and (iii) progesterone resistance...
May 2010: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
Svenja Allhorn, Carsten Böing, Andrea A Koch, Rainer Kimmig, Isabella Gashaw
BACKGROUND: Toll-like receptors (TLRs) play an essential role in the innate immune system by initiating and directing immune response to pathogens. TLRs are expressed in the human endometrium and their regulation might be crucial for the pathogenesis of endometrial diseases. METHODS: TLR3 and TLR4 expression was investigated during the menstrual cycle and in postmenopausal endometrium considering peritoneal endometriosis, hyperplasia, and endometrial adenocarcinoma specimens (grade 1 to 3)...
September 7, 2008: Reproductive Biology and Endocrinology: RB&E
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