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https://www.readbyqxmd.com/read/27783702/who-treats-patients-with-diabetes-and-compensated-cirrhosis
#1
Tsai-Ling Liu, A Sidney Barritt Iv, Morris Weinberger, John E Paul, Bruce Fried, Justin G Trogdon
BACKGROUND: Increasingly, patients with multiple chronic conditions are being managed in patient-centered medical homes (PCMH) that coordinate primary and specialty care. However, little is known about the types of providers treating complex patients with diabetes and compensated cirrhosis. OBJECTIVE: We examined the mix of physician specialties who see patients dually-diagnosed with diabetes and compensated cirrhosis. DESIGN: Retrospective cross-sectional study using 2000-2013 MarketScan® Commercial Claims and Encounters and Medicare Supplemental Databases...
2016: PloS One
https://www.readbyqxmd.com/read/27686908/we-need-compassion-through-listening
#2
Barry Quinn
'To find grace, watch a 16-year-old carer feed an 85-year-old woman with severe dementia, but pass by those in the office writing care plans' ( Barritt 2005 ).
September 30, 2016: Nursing Management (Harrow)
https://www.readbyqxmd.com/read/27637302/the-history-of-antithrombotic-therapy-the-discovery-of-heparin-the-vitamin-k-antagonists-and-the-utility-of-aspirin
#3
REVIEW
Robert I Handin
The administration of intravenous heparin to postoperative patients by Barritt and Jordan reduced the incidence of fatal and nonfatal pulmonary embolism and established heparin as the standard for parenteral anticoagulation. The coumarin family of vitamin K antagonists quickly became the standard for long-term oral anticoagulation. Aspirin became a widely used antithrombotic agent after the discovery that chronic oral administration reduced the incidence of secondary strokes and myocardial infarction. This article gives a brief history of antithrombotic therapy, including the discovery of heparin, the vitamin k antagonists, and the utility of aspirin...
October 2016: Hematology/oncology Clinics of North America
https://www.readbyqxmd.com/read/27486010/nafld-and-liver-transplantation-current-burden-and-expected-challenges
#4
Raluca Pais, A Sidney Barritt, Yvon Calmus, Olivier Scatton, Thomas Runge, Pascal Lebray, Thierry Poynard, Vlad Ratziu, Filomena Conti
Because of global epidemics of obesity and type 2 diabetes, the prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing both in Europe and the United States, becoming one of the most frequent causes of chronic liver disease and predictably, one of the leading causes of liver transplantation both for end-stage liver disease and hepatocellular carcinoma. For most transplant teams around the world this will raise many challenges in terms of pre- and post-transplant management. Here we review the multifaceted impact of NAFLD on liver transplantation and will discuss: (1) NAFLD as a frequent cause of cryptogenic cirrhosis, end-stage chronic liver disease, and hepatocellular carcinoma; (2) prevalence of NAFLD as an indication for liver transplantation both in Europe and the United States; (3) the impact of NAFLD on the donor pool; (4) the access of NAFLD patients to liver transplantation and their management on the waiting list in regard to metabolic, renal and vascular comorbidities; (5) the prevalence and consequences of post-transplant metabolic syndrome, recurrent and de novo NAFLD; (6) the alternative management and therapeutic options to improve the long-term outcomes with particular emphasis on the correction and control of metabolic comorbidities...
July 30, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27401401/characterization-of-the-cytochrome-p450-epoxyeicosanoid-pathway-in-non-alcoholic-steatohepatitis
#5
Michael A Wells, Kimberly C Vendrov, Matthew L Edin, Brian C Ferslew, Weibin Zha, Bobbie K H Nguyen, Rachel J Church, Fred B Lih, Laura M DeGraff, Kim L R Brouwer, A Sidney Barritt, Darryl C Zeldin, Craig R Lee
Non-alcoholic steatohepatitis (NASH) is an emerging public health problem without effective therapies. Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into bioactive epoxyeicosatrienoic acids (EETs), which have potent anti-inflammatory and protective effects. However, the functional relevance of the CYP epoxyeicosanoid metabolism pathway in the pathogenesis of NASH remains poorly understood. Our studies demonstrate that both mice with methionine-choline deficient (MCD) diet-induced NASH and humans with biopsy-confirmed NASH exhibited significantly higher free EET concentrations compared to healthy controls...
September 2016: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/27337756/rapid-diagnosis-vital-in-thunderclap-headache
#6
REVIEW
Andrew Barritt, Sarah Miller, Indran Davagnanam, Manjit Matharu
Thunderclap headache is a severe and acute headache that reaches maximum intensity in under one minute and lasts for more than five minutes. Subarachnoid haemorrhage (SAH) accounts for 10-25% of all thunderclap headaches and, despite advances in medical technology, has a 90-day mortality of 30%. Up to a quarter of cases of SAH are misdiagnosed, often through failure to follow guidance. Thunderclap headaches may be associated with symptoms such as photophobia, nausea, vomiting, neck pain, focal neurological symptoms or loss of consciousness...
April 2016: Practitioner
https://www.readbyqxmd.com/read/27258535/reduced-impact-of-renal-failure-on-the-outcome-of-patients-with-alcoholic-liver-disease-undergoing-liver-transplantation
#7
Jaeyoun Cheong, Joseph A Galanko, Sumant Arora, Joaquin Cabezas, Nambi J Ndugga, Michael R Lucey, Paul H Hayashi, Alfred Sidney Barritt, Ramon Bataller
BACKGROUND & AIMS: Pretransplant renal failure is commonly reported to be a poor prognostic indicator affecting survival after liver transplantation (LT). However, whether the impact of renal failure on patient outcome varies according to the aetiology of the underlying liver disease is largely unknown. METHODS: We investigated the association between renal failure at the time of LT and patient outcome in patients with alcoholic liver disease (ALD) (n = 6920), non-alcoholic steatohepatitis (NASH) (n = 2956) and hepatitis C (HCV) (n = 14 922) using the United Network for Organ Sharing (UNOS) database between February 2002 and December 2013...
June 3, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27178543/the-glucagon-like-peptide-1-analogue-exendin-4-reverses-impaired-intracellular-ca-2-signalling-in-steatotic-hepatocytes
#8
Eunüs S Ali, Jin Hua, Claire H Wilson, George A Tallis, Fiona H Zhou, Grigori Y Rychkov, Greg J Barritt
The release of Ca(2+) from the endoplasmic reticulum (ER) and subsequent replenishment of ER Ca(2+) by Ca(2+) entry through store-operated Ca(2+) channels (SOCE) play critical roles in the regulation of liver metabolism by adrenaline, glucagon and other hormones. Both ER Ca(2+) release and Ca(2+) entry are severely inhibited in steatotic hepatocytes. Exendin-4, a slowly-metabolised glucagon-like peptide-1 (GLP-1) analogue, is known to reduce liver glucose output and liver lipid, but the mechanisms involved are not well understood...
September 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27048904/intestinal-microbiota-in-liver-disease
#9
REVIEW
Tanvir R Haque, A Sidney Barritt
The intestinal microbiota have emerged as a topic of intense interest in gastroenterology and hepatology. The liver is on the front line as the first filter of nutrients, toxins and bacterial metabolites from the intestines and we are becoming increasingly aware of interactions among the gut, liver and immune system as important mediators of liver health and disease. Manipulating the microbiota with therapeutic intent is a rapidly expanding field. In this review, we will describe what is known about the contribution of intestinal microbiota to liver homeostasis; the role of dysbiosis in the pathogenesis of liver disease including alcoholic and non-alcoholic fatty liver disease, cirrhosis and hepatocellular carcinoma; and the therapeutic manifestations of altering intestinal microbiota via antibiotics, prebiotics, probiotics and fecal microbiota transplantation...
February 2016: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/27035077/mixed-cryoglobulin-induced-esophageal-necrosis-in-a-patient-with-hepatitis-c
#10
Maureen Kimani, Jama M Darling, Alfred Sidney Barritt
No abstract text is available yet for this article.
July 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/26609559/curcumin-inhibits-activation-of-trpm2-channels-in-rat-hepatocytes
#11
E Kheradpezhouh, G J Barritt, G Y Rychkov
Oxidative stress is a hallmark of many liver diseases including viral and drug-induced hepatitis, ischemia-reperfusion injury, and non-alcoholic steatohepatitis. One of the consequences of oxidative stress in the liver is deregulation of Ca(2+) homeostasis, resulting in a sustained elevation of the free cytosolic Ca(2+) concentration ([Ca(2+)]c) in hepatocytes, which leads to irreversible cellular damage. Recently it has been shown that liver damage induced by paracetamol and subsequent oxidative stress is, in large part, mediated by Ca(2+) entry through Transient Receptor Potential Melastatin 2 (TRPM2) channels...
April 2016: Redox Biology
https://www.readbyqxmd.com/read/26408196/truncated-amyloid-%C3%AE-11-40-42-from-alzheimer-disease-binds-cu2-with-a-femtomolar-affinity-and-influences-fiber-assembly
#12
Joseph D Barritt, John H Viles
Alzheimer disease coincides with the formation of extracellular amyloid plaques composed of the amyloid-β (Aβ) peptide. Aβ is typically 40 residues long (Aβ(1-40)) but can have variable C and N termini. Naturally occurring N-terminally truncated Aβ(11-40/42) is found in the cerebrospinal fluid and has a similar abundance to Aβ(1-42), constituting one-fifth of the plaque load. Based on its specific N-terminal sequence we hypothesized that truncated Aβ(11-40/42) would have an elevated affinity for Cu(2+)...
November 13, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26327134/burden-of-gastrointestinal-liver-and-pancreatic-diseases-in-the-united-states
#13
Anne F Peery, Seth D Crockett, Alfred S Barritt, Evan S Dellon, Swathi Eluri, Lisa M Gangarosa, Elizabeth T Jensen, Jennifer L Lund, Sarina Pasricha, Thomas Runge, Monica Schmidt, Nicholas J Shaheen, Robert S Sandler
BACKGROUND & AIMS: Gastrointestinal (GI), liver, and pancreatic diseases are a source of substantial morbidity, mortality, and cost in the United States. Quantification and statistical analyses of the burden of these diseases are important for researchers, clinicians, policy makers, and public health professionals. We gathered data from national databases to estimate the burden and cost of GI and liver disease in the United States. METHODS: We collected statistics on health care utilization in the ambulatory and inpatient setting along with data on cancers and mortality from 2007 through 2012...
December 2015: Gastroenterology
https://www.readbyqxmd.com/read/26256813/naming-the-dead-confronting-the-realities-of-rapid-identification-of-degraded-skeletal-remains
#14
REVIEW
S M Edson, J P Ross, M D Coble, T J Parsons, S M Barritt
The Armed Forces DNA Identification Laboratory (AFDIL) is one of the leading laboratories in the world for the processing of degraded skeletal remains. Extended efforts have been made to develop protocols and standards that will hold up to the intense scrutiny of both the scientific world and the U.S. legal system. Presented in this paper are the specifics of the in-house systems and procedures that have allowed AFDIL to streamline the processing of degraded skeletal remains and family references for mitochondrial DNA (mtDNA) analysis...
January 2004: Forensic Science Review
https://www.readbyqxmd.com/read/26138654/altered-bile-acid-metabolome-in-patients-with-nonalcoholic-steatohepatitis
#15
COMPARATIVE STUDY
Brian C Ferslew, Guoxiang Xie, Curtis K Johnston, Mingming Su, Paul W Stewart, Wei Jia, Kim L R Brouwer, A Sidney Barritt
BACKGROUND AND AIMS: The prevalence of nonalcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) is increasing at an alarming rate. The role of bile acids in the development and progression of NAFLD to NASH and cirrhosis is poorly understood. This study aimed to quantify the bile acid metabolome in healthy subjects and patients with non-cirrhotic NASH under fasting conditions and after a standardized meal. METHODS: Liquid chromatography tandem mass spectroscopy was used to quantify 30 serum and 16 urinary bile acids from 15 healthy volunteers and 7 patients with biopsy-confirmed NASH...
November 2015: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/25939487/declining-liver-graft-quality-threatens-the-future-of-liver-transplantation-in-the-united-states
#16
Eric S Orman, Maria E Mayorga, Stephanie B Wheeler, Rachel M Townsley, Hector H Toro-Diaz, Paul H Hayashi, A Sidney Barritt
National liver transplantation (LT) volume has declined since 2006, in part because of worsening donor organ quality. Trends that degrade organ quality are expected to continue over the next 2 decades. We used the United Network for Organ Sharing (UNOS) database to inform a 20-year discrete event simulation estimating LT volume from 2010 to 2030. Data to inform the model were obtained from deceased organ donors between 2000 and 2009. If donor liver utilization practices remain constant, utilization will fall from 78% to 44% by 2030, resulting in 2230 fewer LTs...
August 2015: Liver Transplantation
https://www.readbyqxmd.com/read/25669174/altered-morphine-glucuronide-and-bile-acid-disposition-in-patients-with-nonalcoholic-steatohepatitis
#17
B C Ferslew, C K Johnston, E Tsakalozou, A S Bridges, M F Paine, W Jia, P W Stewart, A S Barritt, K L R Brouwer
The functional impact of altered drug transport protein expression on the systemic pharmacokinetics of morphine, hepatically derived morphine glucuronide (morphine-3- and morphine-6-glucuronide), and fasting bile acids was evaluated in patients with biopsy-confirmed nonalcoholic steatohepatitis (NASH) compared to healthy subjects. The maximum concentration (Cmax ) and area under the concentration-time curve (AUC0-last ) of morphine glucuronide in serum were increased in NASH patients (343 vs. 225 nM and 58...
April 2015: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/25623044/decreasing-mortality-among-patients-hospitalized-with-cirrhosis-in-the-united-states-from-2002-through-2010
#18
Monica L Schmidt, A Sidney Barritt, Eric S Orman, Paul H Hayashi
BACKGROUND & AIMS: It is not clear whether evidence-based recommendations for inpatient care of patients with cirrhosis are implemented widely or are effective in the community. We investigated changes in inpatient outcomes and associated features over time. METHODS: By using the Healthcare Cost and Utilization Project, National Inpatient Sample, we analyzed 781,515 hospitalizations of patients with cirrhosis from 2002 through 2010. We compared data with those from equal numbers of hospitalizations of patients without cirrhosis and patients with congestive heart failure (CHF), matched for age, sex, and year of discharge...
May 2015: Gastroenterology
https://www.readbyqxmd.com/read/25422863/steatosis-inhibits-liver-cell-store-operated-ca%C3%A2-%C3%A2-%C2%BA-entry-and-reduces-er-ca%C3%A2-%C3%A2-%C2%BA-through-a-protein-kinase-c-dependent-mechanism
#19
Claire H Wilson, Eunüs S Ali, Nathan Scrimgeour, Alyce M Martin, Jin Hua, George A Tallis, Grigori Y Rychkov, Greg J Barritt
Lipid accumulation in hepatocytes can lead to non-alcoholic fatty liver disease (NAFLD), which can progress to non-alcoholic steatohepatitis (NASH) and Type 2 diabetes (T2D). Hormone-initiated release of Ca²⁺ from the endoplasmic reticulum (ER) stores and subsequent replenishment of these stores by Ca²⁺ entry through SOCs (store-operated Ca²⁺ channels; SOCE) plays a critical role in the regulation of liver metabolism. ER Ca²⁺ homoeostasis is known to be altered in steatotic hepatocytes. Whether store-operated Ca²⁺ entry is altered in steatotic hepatocytes and the mechanisms involved were investigated...
March 1, 2015: Biochemical Journal
https://www.readbyqxmd.com/read/25391681/predicting-liver-transplant-capacity-using-discrete-event-simulation
#20
Hector Toro-Díaz, Maria E Mayorga, A Sidney Barritt, Eric S Orman, Stephanie B Wheeler
The number of liver transplants (LTs) performed in the US increased until 2006 but has since declined despite an ongoing increase in demand. This decline may be due in part to decreased donor liver quality and increasing discard of poor-quality livers. We constructed a discrete event simulation (DES) model informed by current donor characteristics to predict future LT trends through the year 2030. The data source for our model is the United Network for Organ Sharing database, which contains patient-level information on all organ transplants performed in the US...
August 2015: Medical Decision Making: An International Journal of the Society for Medical Decision Making
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