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https://www.readbyqxmd.com/read/29141361/-effect-of-probucol-on-preventing-contrast-induced-nephropathy-in-patients-undergoing-percutaneous-coronary-intervention
#1
X Q Suo, S C Yang, Z H Ma, T T Sun, W Y Zhang, H L Cong, W H Lin, C Z Lu, F S Tian, N K Fu
Objective: To investigate the preventive effect, possible mechanism and safety of probucol on contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD). Methods: A total of 641 patients with coronary heart disease were consecutively enrolled from Department of Cardiology, in Tianjin Chest Hospital, Tianjin TEDA International Cardiovascular Hospital, Tianjin First Central Hospital, Tianjin Fourth Central Hospital. They were randomly divided into probucol group (n=321) and control group (n=320)...
November 7, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29139249/-clinical-features-analysis-of-qingkailing-injection-for-adolescent-patients-based-on-real-world-his
#2
Li-Zhen Chen, Yan-Ming Xie, Lian-Xin Wang, Yin Zhang, Qun Wang, Ping-Ping Jia, Bo Feng
To explore the clinical application features of Qingkailing injection for adolescent patients. This study was based on the information from the hospitalized patients in 1998-2011 in HIS (hospital information system) of 16 tertiary hospitals in China. 615 adolescent patients with Qingkailing injection were used to investigate the clinical characteristics of Qingkailing injection. Apriori algorithm was adopted to establish the model, and Clementine 12.0 was used for correlation analysis. The results showed that male patients (355 cases) were more than female patients (243 cases); the age of the most patients was under 14 years old, with an average age of 9...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29137238/significance-of-nlda-the-commixed-index-of-inflammation-immune-responses-hemostasis-and-nutrition-for-predicting-metastatic-non-small-cell-lung-cancer-prognosis-and-metastases
#3
Wen-Wen Sun, Jia-An Hu, Wen-Quan Niu, Bei-Li Gao, Zhi-Hong Xu
Purpose: This study aimed to take a comprehensive review of the hematological indexes and discover a novel, comprehensive, and economical index for prognostic prediction. Results: The predictive prognostic model revealed that an elevated value of NLDA (NLDA = neutrophil count/lymphocyte count × D-dimer count/albumin) was an independent risk factor for one-year adverse prognosis (hazard ratio = 3.038; 95% confidence interval [CI], 1.959-4.712; P < 0.001). The C-indexes of internal and external validation in nomogram were 0...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137099/chemoembolization-for-hepatocellular-carcinoma-fed-by-right-internal-thoracic-artery
#4
Tao Shen, Zhongzhi Jia, Yuanquan Huang, Shaoqin Li, Guomin Jiang, Lihua Cheng
The purpose of the study was to evaluate the value of transarterial chemoembolization (TACE) via right internal thoracic artery (RITA) for patients with unresectable hepatocellular carcinoma (HCC).From January 2000 to June 2016, a retrospective study was conducted of all patients with unresectable HCC who underwent TACE via RITA across 3 medical centers. The technical success, serum alpha-fetoprotein (AFP) level changes, major complications, disease control rate, and survival were evaluated and analyzed.During the study peroid, in all, 21 patients (men 21; mean age 57...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29136819/alteration-in-the-liver-metabolome-of-rats-with-metabolic-syndrome-after-treatment-with-hydroxytyrosol-a-mass-spectrometry-and-nuclear-magnetic-resonance-based-metabolomics-study
#5
Ioanna Dagla, Dimitra Benaki, Eirini Baira, Nikolaos Lemonakis, Hemant Poudyal, Lindsay Brown, Anthony Tsarbopoulos, Alexios-Leandros Skaltsounis, Emmanouel Mikros, Evagelos Gikas
Metabolic syndrome (MetS) represents a group of abnormalities that enhances the risk for cardiovascular disease, diabetes and stroke. The Mediterranean diet seems to be an important dietary pattern, which reduces the incidence of MetS. Hydroxytyrosol (HT) - a simple phenol found in olive oil - has received increased attention for its antioxidant activity. Recently, the European Foods Safety Authority (EFSA) claimed that dietary consumption of HT exhibits a protective role against cardiovascular disease. In this study, an experimental protocol has been setup, including isolated HT administration in a diet induced model of MetS in young Wistar rats, in order to find out whether HT has a protective effect against MetS...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136618/hepcidin-in-iron-homeostasis-diagnostic-and-therapeutic-implications-in-type-2-diabetes-mellitus-patients
#6
Sintayehu Ambachew, Belete Biadgo
The prevalence of type 2 diabetes is increasing in epidemic proportions worldwide. Evidence suggests body iron overload is frequently linked and observed in patients with type 2 diabetes. Body iron metabolism is based on iron conservation and recycling by which only a part of the daily need is replaced by duodenal absorption. The principal liver-produced peptide called hepcidin plays a fundamental role in iron metabolism. It directly binds to ferroportin, the sole iron exporter, resulting in the internalization and degradation of ferroportin...
November 15, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/29135986/splenomegaly-diagnostic-validity-work-up-and-underlying-causes
#7
Emelie Curovic Rotbain, Dennis Lund Hansen, Ove Schaffalitzky de Muckadell, Flemming Wibrand, Allan Meldgaard Lund, Henrik Frederiksen
PURPOSE: Our aim was to assess the validity of the ICD-10 code for splenomegaly in the Danish National Registry of Patients (DNRP), as well as to investigate which underlying diseases explained the observed splenomegaly. BACKGROUND: Splenomegaly is a common finding in patients referred to an internal medical department and can be caused by a large spectrum of diseases, including haematological diseases and liver cirrhosis. However, some patients remain without a causal diagnosis, despite extensive medical work-up...
2017: PloS One
https://www.readbyqxmd.com/read/29135373/high-dose-of-silymarin-in-patients-with-decompensated-liver-disease-a-randomized-controlled-trial
#8
Waleed Fouad Fathalah, Mohamed AbdAllah Abdel Aziz, Neveen Helmy Abou El Soud, Maissa El Said El Raziky
Hepatitis C virus (HCV) is a major public health problem being the most common cause of chronic liver disease in Egypt. HCV-induced decompensated liver cirrhosis patients have a median survival of 2 years even with currently used new treatments. Silymarin is the most commonly used herbal product in chronic liver disease for its anti-inflammatory, antiviral, antioxidant, and antifibrotic effects. The aim of this study was to assess the effects of silymarin in high dose on the clinical and biochemical status of chronic HCV-associated decompensated liver cirrhosis...
November 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29134500/systematic-review-of-the-feasibility-and-future-of-laparoscopic-liver-resection-for-difficult-lesions
#9
REVIEW
Kenichiro Araki, Norio Kubo, Akira Watanabe, Hiroyuki Kuwano, Ken Shirabe
Laparoscopic liver resection (LLR) is now performed widely, but is difficult to accomplish in some anatomical locations, such as the posterosuperior segments (S7 and S8) and caudate lobe (S1). An international survey revealed that lesions in these locations are less frequently indicated for LLR than those in other segments. Recent reports from experienced centers document several case series and present technical tips for treating such lesions. The lateral approach using intercostal (transdiaphragmatic) trocars was reported to be useful for lesions in the posterosuperior segments with a semi- to full-decubitus position...
November 13, 2017: Surgery Today
https://www.readbyqxmd.com/read/29133246/potentially-inappropriate-liver-transplantation-in-the-era-of-the-sickest-first-policy-a-search-for-the-upper-limits
#10
REVIEW
Michael Linecker, Tanja Krones, Thomas Berg, Claus U Niemann, Randolph H Steadman, Philipp Dutkowski, Pierre-Alain Clavien, Ronald W Busuttil, Robert D Truog, Henrik Petrowsky
Liver transplantation has emerged to a highly efficient treatment for a variaty of acute and chronic liver diseases. Organ shortage, however, is becoming an increasing problem worldwide, limiting the applicability of liver transplantation. In addition, potential recipients are becoming sicker, thereby increasing the risk of loosing the graft during transplantation or in the initial post-operative period after liver transplantation (3 months). This trend is challenging the MELD allocation model where sickest candidates are prioritized and no delisting criteria are given...
November 10, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29131857/internal-tissue-references-for-18fluorodeoxyglucose-vascular-inflammation-imaging-implications-for-cardiovascular-risk-stratification-and-clinical-trials
#11
Mark A Ahlman, Davis M Vigneault, Veit Sandfort, Roberto Maass-Moreno, Jenny Dave, Ahmed Sadek, Marissa B Mallek, Mariana A F Selwaness, Peter Herscovitch, Nehal N Mehta, David A Bluemke
INTRODUCTION: 18Fluorodeoxyglucose (FDG) positron emission tomography (PET) uptake in the artery wall correlates with active inflammation. However, in part due to the low spatial resolution of PET, variation in the apparent arterial wall signal may be influenced by variation in blood FDG activity that cannot be fully corrected for using typical normalization strategies. The purpose of this study was to evaluate the ability of the current common methods to normalize for blood activity and to investigate alternative methods for more accurate quantification of vascular inflammation...
2017: PloS One
https://www.readbyqxmd.com/read/29131313/risk-score-to-predict-biliary-leakage-after-elective-liver-resection
#12
K Mohkam, O Farges, E Vibert, O Soubrane, R Adam, F-R Pruvot, J-M Regimbeau, M Adham, E Boleslawski, J-Y Mabrut
BACKGROUND: Biliary leakage remains a major cause of morbidity after liver resection. Previous prognostic studies of posthepatectomy biliary leakage (PHBL) lacked power, population homogeneity, and model validation. The present study aimed to develop a risk score for predicting severe PHBL. METHODS: In this multicentre observational study, patients who underwent liver resection without hepaticojejunostomy in one of nine tertiary centres between 2012 and 2015 were randomly assigned to a development or validation cohort in a 2 : 1 ratio...
November 13, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29128938/liver-fibrosis-noninvasive-assessment-using-supersonic-shear-imaging-and-fib4-index-in-patients-with-non-alcoholic-fatty-liver-disease
#13
Hirohito Takeuchi, Katsutoshi Sugimoto, Hisashi Oshiro, Kunio Iwatsuka, Shin Kono, Yu Yoshimasu, Yoshitaka Kasai, Yoshihiro Furuichi, Kentaro Sakamaki, Takao Itoi
PURPOSE: Shear wave elastography (SWE) has been validated in chronic hepatitis C and B; however, limited data are available in non-alcoholic fatty liver disease (NAFLD). This study aimed to evaluate the accuracy of SWE and FIB4 index for the diagnosis of fibrosis in a cohort of consecutive patients with biopsy-proven NAFLD, and to evaluate the effects of other histologic parameters on SWE measurement. METHODS: Written informed consent was obtained from all patients, and this study was approved by our internal review board and ethics committee...
November 11, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/29124781/vascular-input-function-correction-of-inflow-enhancement-for-improved-pharmacokinetic-modeling-of-liver-dce-mri
#14
Jia Ning, Tilman Schubert, Kevin M Johnson, Alejandro Roldán-Alzate, Huijun Chen, Chun Yuan, Scott B Reeder
PURPOSE: To propose a simple method to correct vascular input function (VIF) due to inflow effects and to test whether the proposed method can provide more accurate VIFs for improved pharmacokinetic modeling. METHODS: A spoiled gradient echo sequence-based inflow quantification and contrast agent concentration correction method was proposed. Simulations were conducted to illustrate improvement in the accuracy of VIF estimation and pharmacokinetic fitting. Animal studies with dynamic contrast-enhanced MR scans were conducted before, 1 week after, and 2 weeks after portal vein embolization (PVE) was performed in the left portal circulation of pigs...
November 10, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29123565/lemierre-s-syndrome-a-rare-cause-of-disseminated-sepsis-requiring-multi-organ-support
#15
John Rae, Katie Misselbrook
Lemierre's syndrome is a rare complication of acute pharyngitis characterised by septicaemia with infective thrombophlebitis of the internal jugular vein, most commonly due to Fusobacterium necrophorum. It characteristically affects healthy young adults causing persistent pyrexia and systemic sepsis presenting several days after an initial pharyngitis. Septic emboli seed via the bloodstream to distant sites including the lung, joints, skin, liver, spleen and brain. Prolonged antimicrobial therapy is required and admission to intensive care common...
November 2017: J Intensive Care Soc
https://www.readbyqxmd.com/read/29121977/intrahepatic-biliary-cystadenoma-mimicking-hydatid-cyst-of-liver-a-clinicopathologic-study-of-six-cases
#16
Zubair Ahmad, Nasir Uddin, Wasim Memon, Jamshid Abdul-Ghafar, Arsalan Ahmed
BACKGROUND: Intrahepatic biliary cystadenomas are rare hepatic neoplasms, which are usually cystic. These tumors are often misdiagnosed as simple liver cysts and hydatid cysts clinically and radiologically owing to nonspecific clinical and radiologic features. These tumors require complete resection, as recurrence and malignant transformation can occur following incomplete excision. It is essential that these tumors be diagnosed accurately so that they can be adequately excised. METHODS: Clinical and radiological features of six cases of biliary cystadenoma are described...
November 10, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29121945/potential-dosimetric-benefits-of-adaptive-tumor-tracking-over-the-internal-target-volume-concept-for-stereotactic-body-radiation-therapy-of-pancreatic-cancer
#17
Konstantina Karava, Stefanie Ehrbar, Oliver Riesterer, Johannes Roesch, Stefan Glatz, Stephan Klöck, Matthias Guckenberger, Stephanie Tanadini-Lang
BACKGROUND: Radiotherapy for pancreatic cancer has two major challenges: (I) the tumor is adjacent to several critical organs and, (II) the mobility of both, the tumor and its surrounding organs at risk (OARs). A treatment planning study simulating stereotactic body radiation therapy (SBRT) for pancreatic tumors with both the internal target volume (ITV) concept and the tumor tracking approach was performed. The two respiratory motion-management techniques were compared in terms of doses to the target volume and organs at risk...
November 9, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29120569/abdominal-ultrasound-%C3%A2-the-leading-method-in-duodenal-gist-diagnostics
#18
Sven Bohnec, Ivan Budimir, Davor Hrabar, Nenad Babić, Ivan Budimir, Marko Nikolić, Ivana Pavić
Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the digestive tract and are generally asymptomatic. A 39-year-old female patient was hospitalized in 2012 at Clinical Department of Internal Medicine, Sestre milosrdnice University Hospital Center, for a focal hypodense irregular circular lesion located in segment III of the left hepatic lobe, accidentally found by ultrasonography and verified by computed tomography. The findings were also verified with nuclear magnetic resonance and esophagogastroduodenoscopy...
March 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29119583/hyperlipidemia-is-associated-with-an-increased-risk-of-clinical-benign-prostatic-hyperplasia
#19
Hung-Jen Shih, Chun-Jen Huang, Jui-An Lin, Ming-Chang Kao, Yen-Chun Fan, Pei-Shan Tsai
BACKGROUND: A high fat diet is associated with risk of benign prostatic hyperplasia (BPH). However, whether hyperlipidemia is associated with BPH remains unclear. This population-based cohort study elucidated whether hyperlipidemia is associated with an increased risk of BPH. METHODS: We used a new-exposure design and analyzed data retrieved from the Taiwan National Health Insurance Database between January 1, 2000 and December 31, 2013. The cohort of men with newly diagnosed hyperlipidemia and the age- and index-date-matched (1:3) nonhyperlipidemia cohort were tracked for incidence of BPH during a 1- to 14-year follow-up...
November 9, 2017: Prostate
https://www.readbyqxmd.com/read/29115927/transcriptomic-responses-to-wounding-meta-analysis-of-gene-expression-microarray-data
#20
Piotr Andrzej Sass, Michał Dąbrowski, Agata Charzyńska, Paweł Sachadyn
BACKGROUND: A vast amount of microarray data on transcriptomic response to injury has been collected so far. We designed the analysis in order to identify the genes displaying significant changes in expression after wounding in different organisms and tissues. This meta-analysis is the first study to compare gene expression profiles in response to wounding in as different tissues as heart, liver, skin, bones, and spinal cord, and species, including rat, mouse and human. RESULTS: We collected available microarray transcriptomic profiles obtained from different tissue injury experiments and selected the genes showing a minimum twofold change in expression in response to wounding in prevailing number of experiments for each of five wound healing stages we distinguished: haemostasis & early inflammation, inflammation, early repair, late repair and remodelling...
November 7, 2017: BMC Genomics
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