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https://www.readbyqxmd.com/read/29793168/olive-oil-polyphenols-reduce-oxysterols-induced-redox-imbalance-and-pro-inflammatory-response-in-intestinal-cells
#1
Gessica Serra, Alessandra Incani, Gabriele Serreli, Laura Porru, M Paola Melis, Carlo I G Tuberoso, Daniela Rossin, Fiorella Biasi, Monica Deiana
Dietary habits may strongly influence intestinal homeostasis. Oxysterols, the oxidized products of cholesterol present in cholesterol-containing foodstuffs, have been shown to exert pro-oxidant and pro-inflammatory effects, altering intestinal epithelial layer and thus contributing to the pathogenesis of human inflammatory bowel diseases and colon cancer. Extra virgin olive oil polyphenols possess antioxidant and anti-inflammatory properties, and concentrate in the intestinal lumen, where may help in preventing intestinal diseases...
May 16, 2018: Redox Biology
https://www.readbyqxmd.com/read/29793161/exposure-of-microcystis-aeruginosa-to-hydrogen-peroxide-and-titanium-dioxide-under-visible-light-conditions-modeling-the-impact-of-hydrogen-peroxide-and-hydroxyl-radical-on-cell-rupture-and-microcystin-degradation
#2
Che-Wei Chang, Xiangchen Huo, Tsair-Fuh Lin
The aims of this study are to evaluate, under visible light conditions, the ability of H2 O2 and TiO2 to produce OH, their quantitative impacts on the cell integrity of Microcystis, and the subsequent release and degradation of microcystins (MCs). A sequential reaction model was developed, including one sub-model to simulate the rupture kinetics for cell integrity of Microcystis, and another to describe the release and degradation of MCs. For cell rupture, the dual-oxidant Delayed Chick-Watson model (DCWM) and dual-oxidant Hom model (HM) were first proposed and developed, giving excellent simulation results of cell rupture kinetics...
May 14, 2018: Water Research
https://www.readbyqxmd.com/read/29793073/bubble-generating-polymersomes-loaded-with-both-indocyanine-green-and-doxorubicin-for-effective-chemotherapy-combined-with-photothermal-therapy
#3
Dunwan Zhu, Fan Fan, Chenlu Huang, Zhiming Zhang, Yu Qin, Li Lu, Hai Wang, Xu Jin, Hanxue Zhao, Hu Yang, Chao Zhang, Jun Yang, Zhipeng Liu, Hongfan Sun, Xigang Leng, Deling Kong, Linhua Zhang
The combination of chemotherapy and photothermaltherapy (PTT) via stimuli-responsive nanovesicles has great potential in tumor treatment. In the present study, bubble-generating polymersomes, which can generate bubbles in response to low pH or hyperthermia, were fabricated to simultaneously encapsulate chemotherapeutic drug and photosensitizing agent for the synergistic chemo-photothermal tumor therapy. Photosensitizer indocyanine green (ICG) was encapsulated into the bilayer of polymersomes formed by amphiphilic triblock copolymer PCL8000 -PEG8000 -PCL8000 through thin film re-hydration method, while chemotherapeutic doxorubicin (DOX) was loaded into the hydrophilic lumen using a transmembrane ammonium bicarbonate gradient loading procedure...
May 21, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29792929/recent-advances-in-intra-articular-drug-delivery-systems-for-osteoarthritis-therapy
#4
REVIEW
Pierre Maudens, Olivier Jordan, Eric Allémann
Osteoarthritis (OA) is the most common degenerative disease of the joint. Despite many reports and numerous clinical trials, OA is not entirely understood, and there is no effective treatment available for this disease. To satisfy this unmet medical need, drug delivery systems (DDSs) containing disease-modifying OA drugs (DMOADs) for intra-articular (IA) administration are required to improve the health of OA patients. DDSs should provide controlled and/or sustained drug release, enabling long-term treatment with a reduced number of injections...
May 21, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29792911/prolonged-drug-release-properties-for-orodispersible-films-by-combining-hot-melt-extrusion-and-solvent-casting-methods
#5
Isabell Speer, Maren Preis, Jörg Breitkreutz
Orodispersible films (ODFs) are an advantageous dosage form to accomplish patient convenience and compliance in oral drug delivery. They provide a number of special application features, such as the ease of administration without water and suitability for patients with swallowing problems. However, this promising dosage form has been limited to immediate release formulations so far. The aim of this study was to develop a thin film produced by solvent casting, which is rapidly disintegrating when placed in the mouth, but which provides prolonged drug release characteristics by incorporating drug-loaded matrix particles (MPs)...
May 21, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29792821/exhaustive-exercise-induced-oxidative-stress-alteration-of-erythrocyte-oxygen-release-capacity
#6
Yanlian Xiong, Yanlei Xiong, Yueming Wang, Yajin Zhao, Yaojin Li, Yang Ren, Ruofeng Wang, Mingzi Zhao, Yitong Hao, Haibei Liu, Xiang Wang
The aim of the present study is to explore the effect of exhaustive running exercise (ERE) in the oxygen release capacity of rat erythrocytes. Rats were divided into sedentary control (C), moderate running exercise (MRE) and exhaustive running exercise groups. The thermodynamics and kinetics properties of the erythrocyte oxygen release process of different groups were tested. We also determined the degree of band-3 oxidative and phosphorylation, anion transport activity and carbonic anhydrase isoform II(CAII) activity...
May 24, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29792775/a-narrative-review-of-the-technical-standards-for-extracorporeal-life-support-devices-pumps-and-oxygenators-in-europe
#7
Matteo Di Nardo, Leen Vercaemst, Justyna Swol, Nicholas Barret, Fabio S Taccone, Maximilian V Malfertheiner, Lars M Broman, Federico Pappalardo, Jan Belohlavek, Thomas Mueller, Roberto Lorusso, Margherita Lonero, Mirko Belliato
This review summarizes the European rules to control the market when introducing new products. In particular, it shows all the steps to achieve the European Conformity (CE Mark), a certification that all new medical products must achieve before being used in Europe. Extracorporeal membrane oxygenation (ECMO) devices are exposed to the same procedures. Hereby, we present some regulatory issues regarding pumps and oxygenators, providing technical details as released by the manufacturers on their websites and information charts...
April 1, 2018: Perfusion
https://www.readbyqxmd.com/read/29792530/manganese-transport-and-toxicity-in-polarized-wif-b-hepatocytes
#8
Khristy J Thompson, Jennifer Hein, Andrew Baez, Jose Carlo Sosa, Marianne Wessling-Resnick
Mn toxicity arises from nutritional problems, community and occupational exposures, and genetic risks. Mn blood levels are controlled by hepatobiliary clearance. The goals of this study were to determine the cellular distribution of Mn transporters in polarized hepatocytes, to establish an in vitro assay for hepatocyte Mn efflux, and to examine possible roles the Mn transporters would play in metal import and export. For these experiments, hepatocytoma WIF-B cells were grown for 12-14 days to achieve maximal polarity...
May 24, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29791801/magnetically-controlled-liposome-aggregates-for-on-demand-release-of-reactive-payloads
#9
Jan Haša, Jaroslav Hanuš, Frantisek Stepanek
A colloidal system able to act as a miniature reactor for on-demand release of reactive payloads has been demonstrated. The system is based on sub-micrometers aggregates consisting of anionic liposomes that act as storage reservoirs for the reactants, superparamagnetic iron oxide nanoparticles (SPION) that enable magnetic positioning in space and controlled release of reactants from the liposomes by radiofrequency stimulation, and an oppositely charged polyelectrolyte (poly-L-lysine) that keeps the constituent elements within the aggregates at a defined ratio...
May 23, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29791774/serotonergic-regulation-of-insulin-secretion
#10
REVIEW
Luis Rodrigo Cataldo Bascuñan, Claire Lyons, Hedvig Bennet, Isabella Artner, Malin Fex
The exact physiological role for the monoamine serotonin (5-HT) in modulation of insulin secretion is yet to be fully understood. Although the presence of this monoamine in islets of Langerhans is well established, it is only with recent advances that the complex signaling network in islets involving 5-HT is being unraveled. With more than fourteen different 5-HT receptors expressed in human islets, and receptor independent mechanisms in insulin producing β-cells, our understanding of 5-HT's regulation of insulin secretion is increasing...
May 23, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29791511/caspase-11-dependent-pyroptosis-of-lung-epithelial-cells-protects-from-melioidosis-while-caspase-1-mediates-macrophage-pyroptosis-and-production-of-il-18
#11
Jinyong Wang, Manoranjan Sahoo, Louis Lantier, Jonathan Warawa, Hector Cordero, Kelly Deobald, Fabio Re
Infection with Burkholderia pseudomallei or B. thailandensis triggers activation of the NLRP3 and NLRC4 inflammasomes leading to release of IL-1β and IL-18 and death of infected macrophages by pyroptosis, respectively. The non-canonical inflammasome composed of caspase-11 is also activated by these bacteria and provides protection through induction of pyroptosis. The recent generation of bona fide caspase-1-deficient mice allowed us to reexamine in a mouse model of pneumonic melioidosis the role of caspase-1 independently of caspase-11 (that was also absent in previously generated Casp1-/- mice)...
May 23, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29791256/nlrp6-induces-pyroptosis-by-activation-of-caspase-1-in-gingival-fibroblasts
#12
W Liu, J Liu, W Wang, Y Wang, X Ouyang
NLRP6, a member of the nucleotide-binding domain, leucine-rich repeat-containing (NLR) innate immune receptor family, has been reported to participate in inflammasome formation. Activation of inflammasome triggers a caspase-1-dependent programming cell death called pyroptosis. However, whether NLRP6 induces pyroptosis has not been investigated. In this study, we showed that NLRP6 overexpression activated caspase-1 and gasdermin-D and then induced pyroptosis of human gingival fibroblasts, resulting in release of proinflammatory mediators interleukin (IL)-1β and IL-18...
May 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29791130/quantification-of-serum-high-mobility-group-box-1-by-liquid-chromatography-high-resolution-mass-spectrometry-implications-for-its-role-in-immunity-inflammation-and-cancer
#13
Liwei Weng, Lili Guo, Anil Vachani, Clementina A Mesaros, Ian Alexander Blair
High mobility group box 1 (HMGB1), is a non-histone chromosomal protein, which can be secreted through a variety of pathways and bind to pattern recognition receptors to release pro-inflammatory cytokines. Previous studies have suggested that HMGB1 is up-regulated in numerous inflammatory diseases and that it could be a biomarker for such diseases. However, these studies used immunoassay-based methods to analyze serum HMGB1. Autoantibodies to HMGB1 in serum are found in healthy control subjects as well as in patients with different diseases...
May 23, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29790928/using-meshes-for-mesh-term-enrichment-and-semantic-analyses
#14
Guangchuang Yu
Summary: Medical Subject Headings (MeSH) is the NLM controlled vocabulary used to manually index articles for MEDLINE/PubMed. MeSH provides unique and comprehensive annotations for life science. The meshes package implements measurement of the semantic similarity of MeSH terms and gene products to help using MeSH vocabulary in knowledge mining. Enrichment analysis to extract the biological meanings from gene list, expression profile and genomic regions is also provided using MeSH annotation...
May 22, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29790801/development-and-characterization-of-polymeric-microparticle-of-poly-d-l-lactic-acid-loaded-with-holmium-acetylacetonate
#15
Mariangela de Burgos M de Azevedo, Vitor H S de Melo, Carlos Roberto J Soares, Douglas M Miyamoto, Ricardo A Katayama, Peterson L Squair, Caio H N Barros, Ljubica Tasic
Biodegradable polymers containing radioactive isotopes such as Holmium 166 (166 Ho) have potential applications as beta particle emitters in tumor tissues. It is also a gamma ray emitter, allowing nuclear imaging of any tissue to be acquired. It is frequently used in the form of complexes such as holmium acetylacetonate (HoAcAc), which may cause damages in tissues next to the targets cancer cells, as it is difficult to control its linkage or healthy tissues radiotherapy effects. Poly(D,L-lactic acid), PDLLA, was used to encapsulate holmium acetylacetonate (HoAcAc) using an emulsion solvent extraction/evaporation technique...
May 23, 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29790797/curcumin-loaded-redox-responsive-mesoporous-silica-nanoparticles-for-targeted-breast-cancer-therapy
#16
Nana Li, Zhi Wang, Yongtai Zhang, Kai Zhang, Jianxu Xie, Ying Liu, Wansi Li, Nianping Feng
HYPOTHESIS: The antitumor applications of curcumin (CUR) are limited because of its low water solubility, poor stability, and low bioavailability. We developed novel nanocarrier systems for tumour targeting and controlled CUR release and evaluated their therapeutic efficacy. EXPERIMENTS: The surface of mesoporous silica nanoparticles (MSN) was modified with hyaluronan (HA) or polyethyleneimine-folic acid (PEI-FA) via disulfide bonds. The capacity of the resultant nanocarriers (MSN-HA and MSN-PEI-FA, respectively) for CUR delivery was evaluated in a breast cancer cell line and a mouse xenograft model...
May 23, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29790695/elevated-beta-thromboglobulin-and-mean-platelet-volume-levels-may-show-persistent-platelet-activation-in-systemic-lupus-erythematosus-patients
#17
Seyit Uyar, Gul Babacan Abanonu, Seval Masatlioglu Pehlevan, Cumali Karatoprak, Meral Ulukoylu Menguc, Alper Daskin, Suleyman Dolu, Refik Demirtunc
BACKGROUND: Patients with systemic lupus erythematosus (SLE) have an increased risk of thrombotic events. Platelets become more active and they enlarge to release proteins from alpha granules for aggregation during the plaque formation period. Beta-thromboglobulin is one of the proteins released from alpha-granules when platelets are activated and used as a marker of platelet activation in vivo. OBJECTIVES: The aim of this study was to evaluate the plasma levels of beta-thromoglobulin and mean platelet volume as markers of the presence of platelet activation in systemic lupus erythematosus patients compared with healthy controls...
May 17, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29790574/investigations-on-velvet-regulatory-mutants-confirm-the-role-of-host-tissue-acidification-and-secretion-of-proteins-in-the-pathogenesis-of-botrytis-cinerea
#18
Nathalie Müller, Michaela Leroch, Julia Schumacher, David Zimmer, Anne Könnel, Klaus Klug, Thomas Leisen, David Scheuring, Frederik Sommer, Timo Mühlhaus, Michael Schroda, Matthias Hahn
The Botrytis cinerea VELVET complex regulates light-dependent development and virulence. The goal of this study was to identify common virulence defects of several VELVET mutants and to reveal their molecular basis. Growth, differentiation, physiology, gene expression and infection of fungal strains were analyzed, and quantitative comparisons of in planta transcriptomes and secretomes were performed. VELVET mutants showed reduced release of citric acid, the major acid secreted by the wild-type, whereas no significant role for oxalic acid was observed...
May 23, 2018: New Phytologist
https://www.readbyqxmd.com/read/29790247/the-promotion-of-tissue-engineering-blood-vessel-patency-by-cgs21680-through-regulating-pro-inflammatory-activities-of-endothelial-progenitor-cell
#19
Wen Chen, Li Xiao, Jian Bai, Wen Zeng, Mingcan Yang, Bingyi Shi, Chuhong Zhu
The mobilization and homing of endothelial progenitor cells (EPCs) contribute to the rapid endothelialization of tissue engineering blood vessel (TEBV). Inflammation can affect TEBV patency, and monocytes/macrophages (MM) are the main effector cells. But it is not clear how EPCs interact with MM after TEBV transplantation. Our results showed acellular materials would not directly cause acute and severe inflammatory responses but activate E-selectin expression in homing EPCs, gradually promoting the polarization of MM to the M1...
May 23, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29790071/impact-of-polar-body-biopsy-on-embryo-morphokinetics-back-to-the-roots-in-preimplantation-genetic-testing
#20
Michael Schenk, Andrea Groselj-Strele, Katharina Eberhard, Elisabeth Feldmeier, Darja Kastelic, Stefanie Cerk, Gregor Weiss
PURPOSE: Polar body biopsy (PBB) is a common technique in preimplantation genetic testing (PGT) to assess the chromosomal status of the oocyte. Numerous studies have been implemented to investigate the impact of biopsies on embryo development; however, information on embryo morphokinetics is still lacking. Hence, we investigated the impact of PBB on morphokinetic parameters in early embryo development. METHODS: Four hundred four embryos (202 PBB, 202 control) were retrospectively analyzed...
May 22, 2018: Journal of Assisted Reproduction and Genetics
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