Li Li, Meizhi Lu, Yiling Peng, Junxin Huang, Xiaoman Tang, Jian Chen, Jing Li, Xue Hong, Meizhi He, Haiyan Fu, Ruiyuan Liu, Fan Fan Hou, Lili Zhou, Youhua Liu
Kidney fibrosis is associated with tubular injury, oxidative stress and activation of interstitial fibroblasts. However, whether these events are somehow connected is poorly understood. In this study, we show that glutathione peroxidase-3 (GPX3) depletion in renal tubular epithelium after kidney injury plays a central role in orchestrating an oxidatively stressed extracellular microenvironment, which drives interstitial fibroblast activation and proliferation. Through transcriptional profiling by RNA-sequencing, we found that the expression of GPX3 was down-regulated in various models of chronic kidney disease (CKD), which was correlated with induction of nicotinamide adenine dinucleotide phosphate (NAPDH) oxidase-4 (NOX4)...
September 1, 2023: Redox Biology