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https://www.readbyqxmd.com/read/29169180/mitochondria-targeted-antioxidant-mito-tempo-protects-against-aldosterone-induced-renal-injury-in-vivo
#1
Wei Ding, Tingyan Liu, Xiao Bi, Zhiling Zhang
BACKGROUND/AIMS: Growing evidence suggests mitochondrial dysfunction (MtD) and the Nlrp3 inflammasome play critical roles in chronic kidney disease (CKD) progression. We previously reported that Aldosterone (Aldo)-induced renal injury in vitro is directly caused by mitochondrial reactive oxygen species (mtROS)-mediated activation of the Nlrp3 inflammasome. Here we aimed to determine whether a mitochondria-targeted antioxidant (Mito-Tempo) could prevent Aldo-induced kidney damage in vivo...
November 23, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29163754/troxerutin-reduces-kidney-damage-against-bde-47-induced-apoptosis-via-inhibiting-nox2-activity-and-increasing-nrf2-activity
#2
Qun Shan, Juan Zhuang, Guihong Zheng, Zifeng Zhang, Yanqiu Zhang, Jun Lu, Yuanlin Zheng
2,2,4,4-Tetrabromodiphenyl ether (BDE-47), one of the persistent organic pollutants, seriously influences the quality of life; however, its pathological mechanism remains unclear. Troxerutin is a flavonoid with pharmacological activity of antioxidation and anti-inflammation. In the present study, we investigated troxerutin against BDE-47-induced kidney cell apoptosis and explored the underlying mechanism. The results show that troxerutin reduced renal cell apoptosis and urinary protein secretion in BDE-47-treated mice...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29159527/melatonin-ameliorates-intrarenal-renin-angiotensin-system-in-a-5-6-nephrectomy-rat-model
#3
Sayaka Ishigaki, Naro Ohashi, Takashi Matsuyama, Shinsuke Isobe, Naoko Tsuji, Takamasa Iwakura, Tomoyuki Fujikura, Takayuki Tsuji, Akihiko Kato, Hiroaki Miyajima, Hideo Yasuda
BACKGROUND: Activation of the intrarenal renin-angiotensin system (RAS) plays a critical role in the pathophysiology of chronic kidney disease (CKD) and hypertension. It has been reported that reactive oxygen species (ROS) are important components of intrarenal RAS activation. Melatonin is recognized as a powerful antioxidant, and we recently reported that impaired nighttime melatonin secretion correlates negatively with urinary angiotensinogen excretion, the surrogate marker of intrarenal RAS activity in patients with CKD...
November 20, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29137368/the-protective-effects-of-carboxyhemoglobin-during-the-resuscitation-from-hemorrhagic-shock-in-rats
#4
Hongyu Liu, Songyan Yu, Yaojun Peng, Xin Chang, Xinguang Yu
Aim: This study was aimed to explore the effects of carboxyhemoglobin on reperfusion injury in hemorrhagic shock, as well as its action time and related mechanisms. Results: CO-RBC group showed milder oxidative injury than O2-RBC group. CO reperfusion did not show advantages in functions of kidney and lung during resuscitation. The level of Bax was decreased in CO-RBC group, especially in early CO-RBC group. Moreover, the autophay-related gene Beclin-1 was down-regulated in CO-RBC and early CO-RBC groups...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29130660/-viability-of-colon-tumor-cells-in-insufficient-nutritional-condition-is-reduced-by-mir-133b-through-regulating-expression-of-gstp1
#5
Ang Li, Chuan Yang, Min Hu
OBJECTIVE: To determine the expression level of GSTP1 in colon tumor tissues at different stages and the effects of GSTP1 expression on colon tumor cells,and to identify miR that regulate the expression of GSTP1. METHODS: Realtime PCR and western blot were used to detect the expression level of GSTP1 in colon tumor tissues. pcDNA3.1GSTP1 was constructed and transfected into human colon tumor cell line HCT116. The apoptosis rate and viability of HCT116 were measured...
September 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29130363/antioxidant-role-of-autophagy-in-maintaining-the-integrity-of-glomerular-capillaries
#6
Jun Matsuda, Tomoko Namba, Yoshitsugu Takabatake, Tomonori Kimura, Atsushi Takahashi, Takeshi Yamamoto, Satoshi Minami, Shinsuke Sakai, Ryuta Fujimura, Jun-Ya Kaimori, Isao Matsui, Takayuki Hamano, Yoko Fukushima, Keiko Matsui, Tomoyoshi Soga, Yoshitaka Isaka
Autophagy is a lysosomal degradation system by which cytosolic materials and damaged organelles are broken down into basic components. To explore the physiological role of autophagy in glomerular endothelial cells (GEnCs), we compared the autophagic flux among cells in the kidney under starvation. Inhibition of autophagy by chloroquine administration significantly increased the number of autophagosomes or autolysosomes in GEnCs and proximal tubular cells, but not in podocytes, suggesting that the GEnCs exhibit substantial autophagic activity...
November 13, 2017: Autophagy
https://www.readbyqxmd.com/read/29128560/renal-toxicity-of-nanoparticles-of-cadmium-sulphide-in-rat
#7
Kavita Rana, Yeshvandra Verma, Varsha Rani, Suresh Vir Singh Rana
During present investigations, renal toxicity of CdSNPs (cadmium sulphide nanoparticles) (ranged 5-9 nm) was estimated in rat employing specific parameters. Treatment on each alternate day for 45 days with CdSNPs (10 mg/kg b.w.) yielded significant increase in Cd-MT (cadmium metallothionein), lipid peroxidation and H2O2 generation in the kidney of rat in comparison to bulk cadmium. Concentration of creatinine also increased in urine of CdSNPs treated rats. Histopathological observations revealed extensive damage in proximal tubules...
November 4, 2017: Chemosphere
https://www.readbyqxmd.com/read/29123378/10h-3-6-diazaphenothiazine-induces-g2-m-phase-cell-cycle-arrest-and-caspase-dependent-apoptosis-and-inhibits-cell-invasion-of-a2780-ovarian-carcinoma-cells-through-the-regulation-of-nf-%C3%AE%C2%BAb-and-birc6-xiap-complexes
#8
Jianxin Zhang, Chen Ming, Wenzhi Zhang, Patrick Nwabueze Okechukwu, Beata Morak-Młodawska, Krystian Pluta, Małgorzata Jeleń, Abdah Md Akim, Kok-Pian Ang, Kah Kooi Ooi
The asymptomatic properties and high treatment resistance of ovarian cancer result in poor treatment outcomes and high mortality rates. Although the fundamental chemotherapy provides promising anticancer activities, it is associated with severe side effects. The derivative of phenothiazine, namely, 10H-3,6-diazaphenothiazine (PTZ), was synthesized and reported with ideal anticancer effects in a previous paper. In this study, detailed anticancer properties of PTZ was examined on A2780 ovarian cancer cells by investigating the cytotoxicity profiles, mechanism of apoptosis, and cell invasion...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29121774/sphingolipids-and-redox-signaling-in-renal-regulation-and-chronic-kidney-diseases
#9
Owais M Bhat, Xinxu Yuan, Guangbi Li, RaMi Lee, Pin Lan Li
SIGNIFICANCE: Sphingolipids play critical roles in the membrane biology and intracellular signaling events that influence cellular behavior and function. Our review focuses on the cellular mechanisms and functional relevance of the cross talk between sphingolipids and redox signaling, which may be critically implicated in the pathogenesis of different renal diseases. Recent Advances: Reactive oxygen species (ROS) and sphingolipids can regulate cellular redox homeostasis through the regulation of NADPH oxidase, mitochondrial integrity, nitric oxide synthase (NOS) and antioxidant enzymes...
November 9, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29115169/protective-effect-of-captopril-against-diazinon-induced-nephrotoxicity-and-neurotoxicity-via-inhibition-of-ros-no-pathway
#10
Milad Vahidirad, Milad Arab-Nozari, Hamidreza Mohammadi, Ehsan Zamani, Fatemeh Shaki
Diazinon (Dz) is a widely used insecticide. It can induce nephrotoxicity and neurotoxicity via oxidative stress. Captopril, an angiotensin-converting enzyme inhibitor, is known for its antioxidant properties. In this study, we used captopril for ameliorating of Dz-induced kidney and brain toxicity in rats. Animals were divided into five groups as follows: negative control (olive oil), Dz (150 mg kg(-1)), captopril (60 and 100 mg kg(-1)) and positive control (N-acetylcysteine 200 mg kg(-1)) were injected intraperitoneally 30 min before Dz...
November 8, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29114949/protective-effect-of-gdnf-engineered-amniotic-fluid-derived-stem-cells-on-the-renal-ischaemia-reperfusion-injury-in-vitro
#11
Jia Wang, Fengzhen Wang, Zhuojun Wang, Shulin Li, Lu Chen, Caixia Liu, Dong Sun
OBJECTIVES: Amniotic fluid-derived stem cells (AFSCs) possessing multilineage differentiation potential are proposed as a novel and accessible source for cell-based therapy and tissue regeneration. Glial-derived neurotrophic factor (GDNF) has been hypothesized to promote the therapeutic effect of AFSCs on markedly ameliorating renal dysfunction. The aim of this study was to investigate whether AFSCs equipped with GDNF (GDNF-AFSCs) had capabilities of attenuating mouse renal tubular epithelial cells (mRTECs) apoptosis and evaluate its potential mechanisms...
November 7, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/29113807/cyanate-improves-insulin-sensitivity-and-hepatic-steatosis-in-normal-and-high-fat-fed-mice-anorexic-and-antioxidative-effects
#12
Seong Sik Kang, Kyo-Cheol Mun, Ji Hae Seo, Misun Choe, Eunyoung Ha
Obesity is an important contributing factor to progression of chronic kidney disease. Cyanate, known as uremic toxin, is an electrophile produced spontaneously from urea or by myeloperoxidase-catalyzed oxidation of thiocyanate. Herein, we explored metabolic effects of cyanate in normal chow diet (NCD)- and high fat diet (HFD)-fed mice. Mice were treated with cyanate (1 mg/mL in drinking water) and fed NCD or HFD. Peritoneal glucose tolerance test (PGTT) and insulin tolerance test (ITT) were performed. Blood urea nitrogen (BUN) and creatinine concentrations were determined...
November 4, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29109043/individual-and-combined-effects-of-fusarium-toxins-on-apoptosis-in-pk15-cells-and-the-protective-role-of-n-acetylcysteine
#13
Wei Zhang, Shihua Zhang, Meiling Zhang, Lige Yang, Baojing Cheng, Jianping Li, Anshan Shan
Deoxynivalenol (DON), zearalenone (ZEN) and fumonisin B1 (FB1) are among the most toxicologically important Fusarium toxins commonly found in nature that lead to nephrotoxicity in animals. The present study investigated that the individual and combined effects of subcytotoxic DON (0.25 μM), ZEN (20 μM) and FB1 (10 μM) on oxidative stress and apoptosis in porcine kidney cells (PK15). In addition, the protective effect of N-acetylcysteine (NAC) against the toxicity of Fusarium toxins was also evaluated...
November 7, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29106395/nadph-oxidase-4-promotes-cisplatin-induced-acute-kidney-injury-via-ros-mediated-programmed-cell-death-and-inflammation
#14
Xiao-Ming Meng, Gui-Ling Ren, Li Gao, Qin Yang, Hai-Di Li, Wei-Feng Wu, Cheng Huang, Lei Zhang, Xiong-Wen Lv, Jun Li
The goal of this study was to elucidate the functional role of Nox4 during acute kidney injury (AKI). NADPH oxidases are a major source of reactive oxygen species (ROS) in the kidney in normal and pathological conditions. Among NADPH oxidase isoforms, NADPH oxidase4 (Nox4) is highly expressed in the kidney and has an important role in kidney diseases, such as diabetic nephropathy and renal carcinoma. We previously found that Nox4 expression significantly increased in the toxic AKI model. However, its functional role and mechanism of action in AKI are still unknown...
November 6, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29073523/molecular-oxidative-stress-markers-in-olive-ridley-turtles-lepidochelys-olivacea-and-their-relation-to-metal-concentrations-in-wild-populations
#15
Adriana A Cortés-Gómez, Patricia Morcillo, Francisco A Guardiola, Cristobal Espinosa, María A Esteban, Alberto Cuesta, Marc Girondot, Diego Romero
Due to their longevity and extensive migration areas, marine turtles are able to accumulate diverse contaminants over many years and as a consequence they represent an interesting bioindicator species for marine ecosystem pollution. Metals provoke toxicological effects in many aquatic animal species, but marine turtles have been under-investigated in this area. Thus, we have determined the presence of certain inorganic elements (As, Cd, Cu, Ni, Pb, Se and Zn) in olive ridley turtles (Lepidochelys olivacea) and related them to metallothionein (MT), superoxide dismutase (SOD), catalase (CAT) and glutathione reductase (GR) transcription and/or enzymatic activities...
October 23, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29069986/chromium-oxide-nanoparticle-induced-biochemical-and-histopathological-alterations-in-the-kidneys-and-brain-of-wistar-rats
#16
Ravish Fatima, Kafil Akhtar, M Mobarak Hossain, Riaz Ahmad
Chromium oxide nanoparticles (Cr2O3 NPs) have a wide range of applications in industry. They are used as pigments, catalysts, wear-resistant or high-temperature-resistant coating material and are used in liquid crystal displays. In view of ever escalating use of NPs, risk assessment becomes obligatory to ensure the safety of both human health and the ecosystem. The present study was designed and conducted to evaluate biochemical changes and histopathological alterations in kidneys and brain of rats, following exposure to Cr2O3 NPs...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/29055172/evaluation-of-the-antioxidant-impact-of-ginger-based-kombucha-on-the-murine-breast-cancer-model
#17
Samaneh Salafzoon, Hamideh Mahmoodzadeh Hosseini, Raheleh Halabian
Background Abnormal metabolism is a common event in cancerous cells. For example, the increase of reactive oxygen species (ROS) production, particularly due to aerobic respiration during invasive stage, results in cancer progression. Herein, the impact of kombucha tea prepared from ginger on the alteration of antioxidant agents was assessed in the breast cancer animal model. Methods Two types of kombucha tea with or without ginger were administered to BALB/c mice before and after tumor challenge. Superoxide dismutase (SOD), catalase, glutathione (GSH) and malondialdehyde (MDA) were evaluated in tumor, liver and kidney...
October 21, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29040977/gene-microarray-integrated-with-high-throughput-proteomics-for-the-discovery-of-transthyretin-in-rhabdomyolysis-induced-acute-kidney-injury
#18
Ou Li, Xiaodong Geng, Qian Ma, Weiwei Wang, Ran Liu, Zhong Yin, Siyang Wang, Guangyan Cai, Xiangmei Chen, Quan Hong
BACKGROUND/AIMS: Rhabdomyolysis, one of the leading causes of acute kidney injury (AKI), develops after trauma, drug toxicity, infections, burns, and physical exertion. The aim of this study was to investigate differences in gene and protein expression to elucidate the pathogenesis of rhabdomyolysis (RM)-induced AKI. METHODS: In this study, we used glycerol induced renal injury as a model of RM-induced AKI. Affymetrix U133 plus 2.0 microarrays were used to perform gene microarray analysis...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29034472/protective-effects-of-curcumin-against-aflatoxicosis-a-comprehensive-review
#19
REVIEW
Mohammad Mohajeri, Behzad Behnam, Arrigo F G Cicero, Amirhossein Sahebkar
Aflatoxicosis is a deleterious medical condition that results from aflatoxins (AFs) or ochratoxins (OTs). Contamination with these toxins exerts detrimental effects on the liver, kidneys, reproductive organs, and also on immunological and cardiovascular systems. Aflatoxicosis is closely associated with overproduction of reactive oxygen species (ROS) as key contributors to oxidative and nitrosative stress responses, and subsequent damages to lipids, proteins, RNA, and DNA. The main target organ for AF toxicity is the liver, where DNA adducts, degranulation of endoplasmic reticulum, increased hepatic lipid peroxide, GSH depletion, mitochondrial dysfunction, and reduction of enzymatic and non-enzymatic antioxidants are manifestations of aflatoxicosis...
October 16, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29032117/protective-effects-of-salvia-miltiorrhiza-on-adenine-induced-chronic-renal-failure-by-regulating-the-metabolic-profiling-and-modulating-the-nadph-oxidase-ros-erk-and-tgf-%C3%AE-smad-signaling-pathways
#20
Hongdie Cai, Shulan Su, Yonghui Li, Huiting Zeng, Zhenhua Zhu, Jianming Guo, Yue Zhu, Sheng Guo, Li Yu, Dawei Qian, Yuping Tang, Jinao Duan
ETHNOPHARMACOLOGICAL RELEVANCE: Chronic renal failure (CRF) is defined as a progressive and irreversible loss of renal function and associated with inflammation and oxidative stress. Salvia miltiorrhiza (SM) is an important Chinese herb used in traditional Chinese medicine for treating cardiovascular diseases. The previous studies showed the SM exhibited significant protective effects on CRF. In this present study, the metabolic profiling changes and action mechanism of SM on CRF were explored...
October 12, 2017: Journal of Ethnopharmacology
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