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NADPH oxidase and renal

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https://www.readbyqxmd.com/read/29567533/high-salt-diet-induces-metabolic-alterations-in-multiple-biological-processes-of-dahl-salt-sensitive-rats
#1
Yanjun Wang, Xiangyang Liu, Chen Zhang, Zhengjun Wang
High salt induced renal disease is a condition resulting from the interactions of genetic and dietary factors causing multiple complications. To understand the metabolic alterations associated with renal disease, we comprehensively analyzed the metabonomic changes induced by high salt intake in Dahl salt-sensitive (SS) rats using GC-MS technology and biochemical analyses. Physiological features, serum chemistry, and histopathological data were obtained as complementary information. Our results showed that high salt (HS) intake for 16 weeks caused significant metabolic alterations in both the renal medulla and cortex involving a variety pathways involved in the metabolism of organic acids, amino acids, fatty acids, and purines...
February 2, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29544198/short-chain-fatty-acid-acetate-ameliorates-sepsis-induced-acute-kidney-injury-by-inhibition-of-nadph-oxidase-signaling-in-t-cells
#2
Naif O Al-Harbi, Ahmed Nadeem, Sheikh F Ahmad, Moureq R Alotaibi, Abdullah F AlAsmari, Wael A Alanazi, Mohammad M Al-Harbi, Ahmad M El-Sherbeeny, Khalid E Ibrahim
Sepsis affects millions of people worldwide and is associated with acute kidney injury (AKI). Innate and adaptive immune cells have been shown to play an important role in AKI through release of various inflammatory mediators which include reactive oxidant species (ROS). Acetate, a short chain fatty acid produced by gut bacteria has anti-inflammatory properties and has also been shown to modulate oxidative stress in different immune cells. Effects of acetate have been shown to be both GPR43 dependent and independent in different cells/tissues...
March 12, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29540859/socs1-targeted-therapy-ameliorates-renal-and-vascular-oxidative-stress-in-diabetes-via-stat1-and-pi3k-inhibition
#3
Laura Lopez-Sanz, Susana Bernal, Carlota Recio, Iolanda Lazaro, Ainhoa Oguiza, Ana Melgar, Luna Jimenez-Castilla, Jesus Egido, Carmen Gomez-Guerrero
Oxidative stress resulting from excessive production of reactive oxygen species (ROS) or impaired antioxidant defenses is closely related to the development of diabetic vascular complications, including nephropathy and atherosclerosis. Chronic activation of Janus kinase/Signal transducer and activator of transcription (JAK/STAT) signaling pathway contributes to diabetic complications by inducing expression of genes involved in cell proliferation, fibrosis, inflammation, and oxidative stress. Suppressors of cytokine signaling (SOCS) family of endogenous JAK/STAT regulators is an attractive target for therapeutic intervention...
March 14, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29527679/renal-protection-by-atorvastatin-in-a-murine-model-of-sickle-cell-nephropathy
#4
Rima S Zahr, Prasanthi Chappa, Hong Yin, Lou A Brown, Kenneth I Ataga, David R Archer
Recent studies have demonstrated pleiotropic effects of statins in various mouse models of kidney disease. In this study, Townes humanized sickle cell mice were treated for 8 weeks with atorvastatin at a dose of 10 mg/kg/day starting at 10 weeks of age. Treatment with atorvastatin significantly reduced albuminuria, and improved both urine concentrating ability and glomerular filtration rate. Atorvastatin also decreased markers of kidney injury and endothelial activation, and ameliorated oxidant stress in renal tissues and peripheral macrophages...
March 12, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29507299/comprehensive-renoprotective-effects-of-ipragliflozin-on-early-diabetic-nephropathy-in-mice
#5
Michitsugu Kamezaki, Tetsuro Kusaba, Kazumi Komaki, Yohei Fushimura, Noriko Watanabe, Kisho Ikeda, Takashi Kitani, Noriyuki Yamashita, Masahiro Uehara, Yuhei Kirita, Yayoi Shiotsu, Ryosuke Sakai, Takuya Fukuda, Masahiro Yamazaki, Michiaki Fukui, Satoaki Matoba, Keiichi Tamagaki
Clinical and experimental studies have shown that sodium glucose co-transporter 2 inhibitors (SGLT2i) contribute to the prevention of diabetic kidney disease progression. In order to clarify its pharmacological effects on the molecular mechanisms underlying the development of diabetic kidney disease, we administered different doses of the SGLT2i, ipragliflozin, to type 2 diabetic mice. A high-dose ipragliflozin treatment for 8 weeks lowered blood glucose levels and reduced urinary albumin excretion. High- and low-dose ipragliflozin both inhibited renal and glomerular hypertrophy, and reduced NADPH oxidase 4 expression and subsequent oxidative stress...
March 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29503620/oxidative-stress-and-renal-fibrosis-recent-insights-for-the-development-of-novel-therapeutic-strategies
#6
REVIEW
Wenshan Lv, George W Booz, Fan Fan, Yangang Wang, Richard J Roman
Chronic kidney disease (CKD) is a significant worldwide healthcare problem. Regardless of the initial injury, renal fibrosis is the common final pathway leading to end stage renal disease. Although the underlying mechanisms are not fully defined, evidence indicates that besides inflammation, oxidative stress plays a crucial role in the etiology of renal fibrosis. Oxidative stress results from an imbalance between the production of free radicals that are often increased by inflammation and mitochondrial dysfunction, and reduced anti-oxidant defenses...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29493454/design-and-characterization-of-apocynin-loaded-plga-nanoparticles-and-their-in-vivo-efficacy-in-hyperoxaluric-rats
#7
Satvika Sharma, Ankush Parmar, Rishi Bhardwaj, Tanzeer Kaur
Apocynin has become a drug of choice in NADPH oxidase induced pathological conditions. Hyperoxaluria is one such pathological condition where NADPH oxidase is involved in eliciting renal injury. Recently apocynin has shown to reverse the transcriptome profile of the NADPH oxidase-associated genes and reduced oxidative burden in hyperoxaluric animals. The poor solubility of this drug creates certain apprehensions about its bioavailability. PLGA (Poly Lactic co-Glycolic Acid) encapsulation of drug nanoparticles have showed to induce sustain release and henceforth enhance the efficiency and bioavailability of drugs...
February 28, 2018: Current Drug Delivery
https://www.readbyqxmd.com/read/29483228/vegfr-vascular-endothelial-growth-factor-receptor-inhibition-induces-cardiovascular-damage-via-redox-sensitive-processes
#8
Karla B Neves, Francisco J Rios, Lucas van der Mey, Rheure Alves-Lopes, Alan C Cameron, Massimo Volpe, Augusto C Montezano, Carmine Savoia, Rhian M Touyz
Although VEGF (vascular endothelial growth factor) inhibitors (VEGFIs), are effective anticancer therapies, they cause hypertension through unknown mechanisms. We questioned whether changes in vascular redox state may be important, because VEGF signaling involves nitric oxide (NO) and reactive oxygen species. Molecular mechanisms, including NOS, NADPH oxidase (Nox)-derived reactive oxygen species, antioxidant systems, and vasoconstrictor signaling pathways, were probed in human endothelial cells and vascular smooth muscle exposed to vatalanib, a VEGFI...
February 26, 2018: Hypertension
https://www.readbyqxmd.com/read/29428840/organ-uptake-and-release-of-inorganic-nitrate-and-nitrite-in-the-pig
#9
Karin E Eriksson, Ting Yang, Mattias Carlström, Eddie Weitzberg
Numerous studies have shown beneficial cardiovascular and metabolic effects of dietary nitrate but the release or uptake of these anions on an organ level is still poorly elucidated. Here we administered sodium nitrate in the pig and measured acute changes in release/uptake of nitrate and nitrite across several organs as well as cardiovascular and metabolic functions. In 17 anesthetized pigs multiple venous catheters and arterial ultrasonic blood flow probes were positioned. After pretreatment with the NO synthase (NOS) inhibitor l-NAME to minimize involvement of NOS-dependent nitrate/nitrite generation, the animals received bolus injections of either sodium nitrate or sodium chloride...
February 8, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29413963/renal-protective-effect-of-polysulfide-in-cisplatin-induced-nephrotoxicity
#10
Xu Cao, Xiaowei Nie, Siping Xiong, Lei Cao, Zhiyuan Wu, Philip K Moore, Jin-Song Bian
Cisplatin is a major chemotherapeutic drug for solid tumors whereas it may lead to severe nephrotoxicity. Despite decades of efforts, effective therapies remain largely lacking for this disease. In the current research, we investigated the therapeutic effect of hydrogen polysulfide, a novel hydrogen sulfide (H2S) derived signaling molecule, in cisplatin nephrotoxicity and the mechanisms involved. Our results showed that polysulfide donor Na2S4 ameliorated cisplatin-caused renal toxicity in vitro and in vivo through suppressing intracellular reactive oxygen species (ROS) generation and downstream mitogen-activated protein kinases (MAPKs) activation...
February 1, 2018: Redox Biology
https://www.readbyqxmd.com/read/29402900/canagliflozin-an-sglt2-inhibitor-attenuates-the-development-of-hepatocellular-carcinoma-in-a-mouse-model-of-human-nash
#11
Kumiko Shiba, Kyoichiro Tsuchiya, Chikara Komiya, Yasutaka Miyachi, Kentaro Mori, Noriko Shimazu, Shinobu Yamaguchi, Naomi Ogasawara, Makoto Katoh, Michiko Itoh, Takayoshi Suganami, Yoshihiro Ogawa
Sodium glucose cotransporter 2 (SGLT2) inhibitors, an antidiabetic drug, promotes urinary excretion of glucose by blocking its reabsorption in the renal proximal tubules. It is unclear whether SGLT2 inhibition could attenuate nonalcoholic steatohepatitis (NASH) and NASH-associated hepatocellular carcinoma. We examined the preventive effects of an SGLT2 inhibitor canagliflozin (CANA) in Western diet (WD)-fed melanocortin 4 receptor-deficient (MC4R-KO) mice, a mouse model of human NASH. An eight-week CANA treatment attenuated hepatic steatosis in WD-fed MC4R-KO mice, with increased epididymal fat mass without inflammatory changes...
February 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29399101/vaccarin-alleviates-hypertension-and-nephropathy-in-renovascular-hypertensive-rats
#12
Weiwei Cai, Zhenpeng Zhang, Yiqi Huang, Haijian Sun, Liying Qiu
The kidney is an important organ in the regulation of blood pressure, and it is also one of the primary target organs of hypertension. Kidney damage in response to hypertension eventually leads to renal insufficiency. The authors previously demonstrated that vaccarin exhibits a protective role in endothelial injury. However, the effects of vaccarin on the two-kidney, one clip (2K1C) renovascular hypertension model and subsequent kidney injury have yet to be fully elucidated. The present study was designed to investigate the roles and mechanisms of vaccarin in attenuating hypertension and whether vaccarin had beneficial effects on kidney injury...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29329393/tgf-%C3%AE-mediated-nadph-oxidase-4-dependent-oxidative-stress-promotes-colistin-induced-acute-kidney-injury
#13
Bo Young Jeong, Se-Ra Park, Sungkwon Cho, Seong-Lan Yu, Hoi Young Lee, Chang Gyo Park, Jaeku Kang, Da-Young Jung, Moon Hyang Park, Won-Min Hwang, Sung-Ro Yun, Ju-Young Jung, Se-Hee Yoon
Background: Colistin (polymyxin E) is an important constituent of the polymyxin class of cationic polypeptide antibiotics. Intrarenal oxidative stress can contribute to colistin-induced nephrotoxicity. Nicotinamide adenine dinucleotide 3-phosphate oxidases (Noxs) are important sources of reactive oxygen species. Among the various types of Noxs, Nox4 is predominantly expressed in the kidney. Objectives: We investigated the role of Nox4 and benefit of Nox4 inhibition in colistin-induced acute kidney injury using in vivo and in vitro models...
April 1, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29316804/renal-protective-effect-of-hydrogen-sulfide-in-cisplatin-induced-nephrotoxicity
#14
Xu Cao, Siping Xiong, Yebo Zhou, Zhiyuan Wu, Lei Ding, Yike Zhu, Mark E Wood, Matthew Whiteman, Philip K Moore, Jin-Song Bian
AIMS: Cisplatin is a major therapeutic drug for solid tumors, but can cause severe nephrotoxicity. However, the role and therapeutic potential of hydrogen sulfide (H2 S), an endogenous gasotransmitter, in cisplatin-induced nephrotoxicity remain to be defined. RESULTS: Cisplatin led to the impairment of H2 S production in vitro and in vivo by downregulating the expression level of cystathionine γ-lyase (CSE), which may contribute to the subsequent renal proximal tubule (RPT) cell death and thereby renal toxicity...
February 21, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29280941/superoxide-anions-and-no-in-the-paraventricular-nucleus-modulate-the-cardiac-sympathetic-afferent-reflex-in-obese-rats
#15
Qing-Bo Lu, Jing Sun, Ying Kang, Hai-Jian Sun, Hui-Shan Wang, Yuan Wang, Guo-Qing Zhu, Ye-Bo Zhou
This study was conducted to explore the hypothesis that the endogenous superoxide anions (O₂- ) and nitric oxide (NO) system of the paraventricular nucleus (PVN) regulates the cardiac sympathetic afferent reflex (CSAR) contributing to sympathoexcitation in obese rats induced by a high-fat diet (42% kcal as fat) for 12 weeks. CSAR was evaluated by monitoring the changes of renal sympathetic nerve activity (RSNA) and the mean arterial pressure (MAP) responses to the epicardial application of capsaicin (CAP) in anaesthetized rats...
December 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29277549/the-mtor-promotes-oxidative-stress-induced-apoptosis-of-mesangial-cells-in-diabetic-nephropathy
#16
Qian Lu, Yuexian Zhou, Meng Hao, Chengcheng Li, Jin Wang, Fanglin Shu, Lei Du, Xia Zhu, Qiaoli Zhang, Xiaoxing Yin
Glomerular mesangial cell (MC) apoptosis is one of the important mechanisms of glomerulosclerosis, which induces an increased severity of albuminuria and promotes the development of diabetic nephropathy (DN). However, the mechanism by which high glucose (HG) induces MCs apoptosis is not fully understood. In the present study, we investigated the effects of mTOR signalling on apoptosis in cultured MCs exposed to HG and in type I diabetes, and tried to clarify the specific mechanisms underlying these effects...
December 24, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29262407/the-role-of-%C3%AE-adrenergic-overstimulation-in-the-early-stages-of-renal-injury
#17
Mariana Charleaux de Ponte, Fernando Augusto Malavazzi Casare, Juliana Martins Costa-Pessoa, Vanessa Gerolde Cardoso, Gerhard Malnic, Margarida Mello-Aires, Rildo Aparecido Volpini, Karina Thieme, Maria Oliveira-Souza
BACKGROUND/AIMS: To assess the possible contribution of the β-adrenergic overstimulation in early stages of renal injury, the present study evaluated, in rats, the effects of the β-adrenoceptor agonist isoproterenol (ISO) on renal function and morphology, as well as the renal mRNA and protein expression of the NADPH oxidase isoform 4 (Nox 4) and subunit p22phox, endoplasmic reticulum (ER) stress, pro-inflammatory, pro-apoptotic and renin-angiotensin system (RAS) components. METHODS: Wistar rats received ISO (0...
2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29200912/biphasic-augmentation-of-alpha-adrenergic-contraction-by-plumbagin-in-rat-systemic-arteries
#18
Hae Jin Kim, Hae Young Yoo, Yin Hua Zhang, Woo Kyung Kim, Sung Joon Kim
Plumbagin, a hydroxy 1,4-naphthoquinone compound from plant metabolites, exhibits anticancer, antibacterial, and antifungal activities via modulating various signaling molecules. However, its effects on vascular functions are rarely studied except in pulmonary and coronary arteries where NADPH oxidase (NOX) inhibition was suggested as a mechanism. Here we investigate the effects of plumbagin on the contractility of skeletal artery (deep femoral artery, DFA), mesenteric artery (MA) and renal artery (RA) in rats...
November 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29163205/localization-and-interaction-between-kinin-b1-receptor-and-nadph-oxidase-in-the-vascular-system-of-diabetic-rats
#19
Youssef Haddad, Réjean Couture
Kinin B1 receptor (B1R) enhanced superoxide anion ([Formula: see text]) production in the vasculature of diabetic rats. This study investigates the induction and distribution of B1R in diabetic blood vessels and addresses the hypothesis that B1R is co-localized with NADPH oxidase (NOX1 and NOX2) and produces its activation via protein kinase C (PKC). Diabetes was induced in rats with streptozotocin (STZ 65 mg.kg-1 , i.p.). Two weeks later, the production of [Formula: see text] was measured in aorta rings in response to the B1R agonist (Sar[D-Phe8 ]-des-Arg9 -BK, 20 μM) by the method of lucigenin-enhanced chemiluminescence...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29121774/sphingolipids-and-redox-signaling-in-renal-regulation-and-chronic-kidney-diseases
#20
Owais M Bhat, Xinxu Yuan, Guangbi Li, RaMi Lee, Pin-Lan Li
SIGNIFICANCE: Sphingolipids play critical roles in the membrane biology and intracellular signaling events that influence cellular behavior and function. Our review focuses on the cellular mechanisms and functional relevance of the cross talk between sphingolipids and redox signaling, which may be critically implicated in the pathogenesis of different renal diseases. Recent Advances: Reactive oxygen species (ROS) and sphingolipids can regulate cellular redox homeostasis through the regulation of NADPH oxidase, mitochondrial integrity, nitric oxide synthase (NOS), and antioxidant enzymes...
January 9, 2018: Antioxidants & Redox Signaling
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