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Alveolar resorption

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https://www.readbyqxmd.com/read/29763493/clinical-outcomes-of-vertical-distraction-osteogenesis-for-dental-implantation-a-systematic-review-and-meta-analysis
#1
Kai Zhao, Feng Wang, Wei Huang, Yiqun Wu
PURPOSE: The aim of this study was to evaluate the clinical outcomes of vertical distraction osteogenesis (VDO) for patients with vertically deficient alveolar ridges in terms of (1) the cumulative implant survival rate, (2) bone gain, (3) bone resorption before and after implant insertion, and (4) complications. MATERIALS AND METHODS: An electronic search was conducted via MEDLINE (PubMed), EMBASE, and the Cochrane Library, complemented by manual searches, to identify eligible clinical studies of VDO before dental implantation...
May 2018: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29761497/vibration-enhances-pge-2-il-6-and-il-8-expression-in-compressed-hpdl-cells-via-cyclooxygenase-pathway
#2
Pussadee Phusuntornsakul, Suwanna Jitpukdeebodintra, Prasit Pavasant, Chidchanok Leethanakul
BACKGROUND: Although vibration combined with orthodontic force may accelerate orthodontic tooth movement, little is known about the mechanisms that regulate the associated cellular responses. The propose of this study was to investigate whether mechanical vibration combined with compressive force regulates COX-2/PGE2 , IL-6 and IL-8 mRNA and protein expression in human periodontal ligament (hPDL) cells via the cyclooxygenase pathway. METHODS: The primary cultured hPDL cells were exposed to mechanical vibration, compressive force or a combination of both mechanical vibration and compressive force at 24, 48, 72 h...
May 14, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29760142/-in-vitro-and-in-vivo-activity-of-peptidomimetic-compounds-that-target-the-periodontal-pathogen-porphyromonas-gingivalis
#3
Jinlian Tan, Pravin C Patil, Frederick A Luzzio, Donald R Demuth
The interaction of the periodontal pathogen Porphyromonas gingivalis with oral streptococci is important for initial colonization of the oral cavity by P. gingivalis and is mediated by a discrete motif of the streptococcal antigen I/II protein. A synthetic peptide encompassing this motif functions as a potent inhibitor of P. gingivalis adherence but the use of peptides as topically applied therapeutic agents in the oral cavity has limitations arising from the relatively high cost of peptide synthesis and their susceptibility to degradation by proteases expressed by oral organisms...
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29740057/mechanical-adaptation-of-trabecular-bone-morphology-in-the-mammalian-mandible
#4
Peter J Watson, Laura C Fitton, Carlo Meloro, Michael J Fagan, Flora Gröning
Alveolar bone, together with the underlying trabecular bone, fulfils an important role in providing structural support against masticatory forces. Diseases such as osteoporosis or periodontitis cause alveolar bone resorption which weakens this structural support and is a major cause of tooth loss. However, the functional relationship between alveolar bone remodelling within the molar region and masticatory forces is not well understood. This study investigated this relationship by comparing mammalian species with different diets and functional loading (Felis catus, Cercocebus atys, Homo sapiens, Sus scrofa, Oryctolagus cuniculus, Ovis aries)...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29730290/cystathionine-gamma-lyase-h-2-s-contributes-to-osteoclastogenesis-during-bone-remodeling-induced-by-mechanical-loading
#5
Shenzheng Mo, Yongmei Hua
Hydrogen sulfide (H2 S), a gaseous signaling molecule produced by cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS), influences bone remodeling in many ways. Osteoclasts play an important role in bone remodeling during tooth movement induced by mechanical loading, which increases the rate of tooth movement. Recently, we found that osteoclasts could produce H2 S. However, whether H2 S modulates bone remodeling by affecting osteoclasts remains unclear. In this study, we found that CSE-H2 S was a dominant H2 S generating system in osteoclasts, while CBS did not generate H2 S...
May 3, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29724323/-regulatory-effects-of-erythropoietin-producing-hepatocyte-kinase-receptor-and-ephrin-ligand-on-bone-remodeling
#6
Xiao Nan Xu, Ding Zhang
During the process of bone remodeling,the bone homeostasis is tightly controlled by the coupling of bone resorption and bone formation,depending upon cellular communication between osteoclasts and osteoblasts. Many studies have identified that the bi-directional transduction of erythropoietin producing hepatocyte kinase receptor and ephrin ligand (Eph/ephrin) is one of signal transduction pathways in bone remodeling. This review focus on the potential role of Eph/ephrin in bone remodeling,especially in alveolar remodeling...
April 28, 2018: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29723339/comparing-osteogenic-effects-between-concentrated-growth-factors-and-the-acellular-dermal-matrix
#7
RANDOMIZED CONTROLLED TRIAL
Luo Huang, Rui Zou, Jinquan He, Kexiong Ouyang, Zhengguo Piao
Concentrated growth factor (CGF) is an autogenuous product that contains highly concentrated number of platelets and can be derived from venous blood by selective centrifugation. It has been speculated that local growth factors in human platelets (insulinlike growth factor, IGF; transforming growth factor, TGF-b; platelet derived growth factor, PDGF) would enhance healing of grafts and also counteract resorption. The osteogensis effect of CGF and acellular dermal matrix (ADM) for alveolar cleft defects was evaluated in this study...
2018: Brazilian Oral Research
https://www.readbyqxmd.com/read/29714068/effects-of-different-force-magnitudes-on-corticotomy-assisted-orthodontic-tooth-movement-in-rats
#8
Kriangkrai Kraiwattanapong, Bancha Samruajbenjakun
OBJECTIVES: To investigate the effects of light and heavy forces with corticotomy on tooth movement rate, alveolar bone response, and root resorption in a rat model. MATERIALS AND METHODS: The right and left sides of 40 male Wistar rats were randomly assigned using the split-mouth design to two groups: light force with corticotomy (LF) and heavy force with corticotomy (HF). Tooth movement was performed on the maxillary first molars using a nickel-titanium closed-coil spring delivering either 10 g (light force) or 50 g (heavy force)...
May 1, 2018: Angle Orthodontist
https://www.readbyqxmd.com/read/29694352/effects-of-loxoprofen-on-the-apical-root-resorption-during-orthodontic-tooth-movement-in-rats
#9
Taeko Yamamoto, Masato Kaku, Hiromi Sumi, Yuka Yashima, Jin Izumino, Kotaro Tanimoto
Studies have revealed that severe apical root resorption during tooth movement is caused by the noninfective inflammatory reaction of apical root tissues. We hypothesized that loxoprofen can suppress apical root resorption during tooth movement. Cyclic tensile force (CTF) of 10 kPa was applied to the human pulp cells for 48 hours by the Flexcell Strain Unit. Loxoprofen (10 and 100 μM) was added to the culture cells, and expression of cyclooxygenase (COX)-1, COX-2, interleukin (IL)-1β, receptor activator of nuclear factor kappa-B ligand (RANKL), tumor necrosis factor (TNF)-α, and macrophage colony-stimulating factor (M-CSF) were examined...
2018: PloS One
https://www.readbyqxmd.com/read/29692564/effects-of-mangosteen-peel-extract-combined-with-demineralized-freeze-dried-bovine-bone-xenograft-on-osteocalcin-collagen-1-and-osteoblast-as-alveolar-bone-regeneration-in-socket-preservation
#10
Utari Kresnoadi, Tika Raharjo, Rostiny Rostiny
Background: Tooth extraction will provoke changes in alveolar bone morphology and dimensions. Postextraction bone resorption can lead to significant problems for restorative dentistry. Therefore, the extracted tooth socket needs to be preserved to reduce alveolar ridge bone resorption. This research aimed to analyze the expression and levels of osteocalcin, collagen 1, and osteoblasts in extracted tooth sockets filled with a combination of mangosteen peel extract and demineralized freeze-dried bovine bone xenograft (DFDBBX)...
April 2018: Journal of Indian Prosthodontic Society
https://www.readbyqxmd.com/read/29687103/surgical-extrusion-a-simplified-esthetic-method-of-treating-non-restorable-teeth-rationale-and-case-report
#11
Riccardo Becciani, Davide Faganello, Mauro Fradeani
The restoration of teeth that have been compromised by loss of crown and radicular structure due to caries, fractures, root resorption or iatrogenic lesions could result in the violation of the biologic width, with consequent gingival inflammation, loss of attachment, and alveolar bone loss. It is essential in these cases to obtain an adequate enough portion of the tooth structure to allow for a restoration that respects the biologic width. This can be achieved using a procedure that allows for the extrusion of the root in a single step, thereby shifting the compromised site from subgingival to supragingival...
2018: International Journal of Esthetic Dentistry
https://www.readbyqxmd.com/read/29669267/differential-effects-of-natural-curcumin-and-chemically-modified-curcumin-on-inflammation-and-bone-resorption-in-model-of-experimental-periodontitis
#12
Fabiana Almeida Curylofo-Zotti, Muna S Elburki, Priscilla Aparecida Oliveira, Paulo Sérgio Cerri, Leandro Alves Santos, Hsi-Ming Lee, Francis Johnson, Lorne M Golub, Carlos Rossa, Morgana Rodrigues Guimarães-Stabili
OBJECTIVE: The purpose of this study was to compare the effects of the oral administration of natural curcumin and a chemically modified curcumin (CMC2.24) on osteoclast-mediated bone resorption, apoptosis, and inflammation in a murine model of experimental periodontal disease. DESIGN: Fifty male rats were distributed among the following treatment groups: (i) 2% carboxymethylcellulose, (ii) CMC2.24 30 mg/kg body weight, (iii) Curcumin 100 mg/kg body weight and (iv) no treatment...
April 10, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29656537/histological-evaluation-of-the-repair-process-of-replanted-rat-teeth-after-storage-in-resveratrol-dissolved-in-dimethyl-sulfoxide
#13
Wilson Roberto Poi, Celso Koogi Sonoda, Marina Fuzette Amaral, Alfredo Franco Queiroz, Alline Batistussi França, Daniela Atili Brandini
BACKGROUND/AIM: The storage media is directly related to the prognosis of avulsed teeth, with resveratrol drawing attention due to its antioxidant and anti-inflammatory proprieties. The aim of this study was to evaluate the repair process in rat teeth following delayed replantation after storage in resveratrol (R) dissolved in dimethyl sulfoxide (DMSO). MATERIAL AND METHODS: The upper right central incisors of 36 rats were divided into 4 groups. In Group I, the teeth were extracted and immediately replanted...
April 14, 2018: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/29656307/alveolar-bone-protective-effect-of-hiziki-extracts-on-the-progression-of-periodontitis
#14
Don-Gil Lee, Yu-Kyong Shin, Jae-Hee Park, Sang-Yong Park, Eunson Hwang, Jung-Eun Yang, Hae Jo, Ki-Young Kim, Gafurjon T Mavlonov, Tae-Hoo Yi
The purpose of this study was to evaluate the effects of hiziki extract on alveolar bone loss, inflammation, and osteo-biomarker expression in hPDL cells (10, 50, 100 μg/ml final concentrations in culture medium) and on a ligature-induced periodontitis rat model (50, 100, 200 mg/kg with oral administration). Hiziki extract increased alkaline phosphatase activity and mineralized nodule formation in hPDL cell. In western blot analysis, hiziki extract resulted in increased expression of osteoblast markers, including transforming growth factor beta (TGF-β), SMAD anchor for receptor activation (SARA) and runt-related transcription factor 2 (RUNX2) in hDPL cells...
April 14, 2018: Marine Biotechnology
https://www.readbyqxmd.com/read/29627610/three-dimensional-cad-cam-imaging-of-the-maxillary-sinus-in-ageing-process
#15
Kvetuse Lovasova, David Kachlik, Mirela Rozpravkova, Maria Matusevska, Jana Ferkova, Darina Kluchova
OBJECTIVES: During the physiological ageing process atrophy of the alveolar bone appears in vertical direction. This bone resorption causes pushing the limits of the maxillary sinus at the expense of a degraded bone. The sinus volume increases due to the facial development in children and adolescents or during the ageing process due to the loss of teeth and bone mass. The main aim of this study is to determine the sinus shape and sinus floor morphology related to age. MATERIALS AND METHODS: Human adult male and female cadaveric heads (aged 37 to 83 years) with different dental status were used...
April 5, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29608684/microsphere-controlled-drug-delivery-for-local-control-of-tooth-movement
#16
Inna Sydorak, Ming Dang, Sarah J Baxter, Michael Halcomb, Peter Ma, Sunil Kapila, Nan Hatch
Background: Because orthodontic tooth movement is dependent upon osteoclast-mediated resorption of alveolar bone adjacent to the pressure side of tooth roots, biologic mediators that regulate osteoclasts can be utilized to control tooth movement. Objectives: To develop a novel method to locally enhance orthodontic anchorage. Methods: We encapsulated osteoprotegerin (OPG) in polymer microspheres and tested the effectiveness of microsphere encapsulated versus non-encapsulated OPG for enhancing orthodontic anchorage in a rodent model of tooth movement...
March 28, 2018: European Journal of Orthodontics
https://www.readbyqxmd.com/read/29607937/anti-mouse-rankl-antibodies-inhibit-alveolar-bone-destruction-in-periodontitis-model-mice
#17
Miku Kuritani, Nobuhiro Sakai, Akiko Karakawa, Motoki Isawa, Masahiro Chatani, Takako Negishi-Koga, Takahiro Funatsu, Masamichi Takami
Denosumab is an anti-bone resorptive drug consisting of complete human monoclonal antibodies that targets receptor activator of nuclear factor κB ligand (RANKL), which is responsible for osteoclast formation. The drug has been adapted for bone diseases, such as osteoporosis and bone metastasis related to cancer, but is not used for alveolar bone destruction related to periodontitis. In the present study, we aimed to clarify whether denosumab prevents bone destruction associated with lipopolysaccharide (LPS)-induced calvaria inflammation and experimental periodontitis in model mice...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29588823/histological-evaluation-of-orthodontic-tooth-movement-following-low-level-laser-irradiation-in-rabbits
#18
Mostafa Abtahi, Nasrollah Saghravanian, Maryam Poosti, Hooman Shafaee
Background: Reduction of orthodontic treatment time is a major concern for orthodontists. Low level laser therapy (LLL) has been widely used in dentistry and it has been claimed that it could stimulate bone formation. Objective: The aim of the present study was to evaluate histological effects of LLL on alveolar bone remodeling during experimental tooth movement in rabbits. Methods: In this experimental study which was performed in the animal lab of Mashhad Dental School in 2016 twenty pre-pubertal female albino rabbits with the mean age of 8±1 weeks were randomly assigned into two groups...
January 2018: Electronic Physician
https://www.readbyqxmd.com/read/29576575/cone-beam-computed-tomographic-evaluation-of-changes-in-maxillary-alveolar-bone-after-orthodontic-treatment
#19
Wakako Miyama, Yasuki Uchida, Mitsuru Motoyoshi, Keiko Motozawa, Moeko Kato, Noriyoshi Shimizu
This study examined the relationship of vertical and horizontal changes in the alveolar bone crest with upper incisor movement after orthodontic treatment. Tooth movement was measured on lateral cephalograms. Vertical and horizontal changes in the median alveolar crest and distance from the cementoenamel junction and anterior nasal spine to the alveolar crest were measured with cone-beam computed tomography. The incisal edge moved distally, and the cervical point intruded significantly and moved distally. The median alveolar crest decreased by 3...
2018: Journal of Oral Science
https://www.readbyqxmd.com/read/29574908/peroxisome-proliferator-activated-receptor-%C3%AE-plays-dual-roles-on-experimental-periodontitis-in-rats
#20
Weiwei Qiao, Changning Wang, Wushuang Huang, Yingying Hu, Yaling Song
AIM: To investigate the effects of peroxisome proliferator-activated receptor γ (PPARγ) on inflammation control and bone remodelling in experimental periodontitis in rats. MATERIALS AND METHODS: Experimental periodontitis was induced in rats by thread ligation around cervixes of mandibular first molars. PPARγ agonist, antagonist and vehicle were intraperitoneally administrated, respectively, into rats. Ninety-six male SD rats were randomly divided into control, ligation + vehicle, ligation + agonist and ligation + antagonist groups...
March 25, 2018: Journal of Clinical Periodontology
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