keyword
MENU ▼
Read by QxMD icon Read
search

Osteoclasts

keyword
https://www.readbyqxmd.com/read/29332162/roles-of-irisin-in-the-linkage-from-muscle-to-bone-during-mechanical-unloading-in-mice
#1
Naoyuki Kawao, Akihiro Moritake, Kohei Tatsumi, Hiroshi Kaji
Mechanical unloading induces disuse muscle atrophy and bone loss, but the details in mechanism involved in those pathophysiological conditions are not fully understood. Interaction between muscle and bone has been recently noted. Here, we investigated the roles of humoral factors linking muscle to bone during mechanical unloading using mice with hindlimb unloading (HU) and sciatic neurectomy (SNX). HU and SNX reduced muscle volume surrounding the tibia, tissue weights of soleus and gastrocnemius muscle, and trabecular bone mineral density (BMD) in the tibia of mice...
January 13, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29332062/cytologic-features-of-malignant-melanoma-with-osteoclast-like-giant-cells
#2
José A Jiménez-Heffernan, Magdalena Adrados, Patricia Muñoz-Hernández, Paloma Fernández-Rico, Ana I Ballesteros-García, Javier Fraga
BACKGROUND: Malignant melanoma showing numerous osteoclast-like giant cells (OGCs) is an uncommon morphologic phenomenon, rarely mentioned in the cytologic literature. The few reported cases seem to have an aggressive clinical behavior. Although most findings support monocyte/macrophage differentiation, the exact nature of OGCs is not clear. CASE: A 57-year-old woman presented with an inguinal lymphadenopathy. Sixteen years before, cutaneous malignant melanoma of the lower limb had been excised...
January 13, 2018: Acta Cytologica
https://www.readbyqxmd.com/read/29330560/altered-bone-remodeling-in-psoriatic-disease-new-insights-and-future-directions
#3
REVIEW
Ananta Paine, Christopher Ritchlin
Psoriatic arthritis (PsA) is an inflammatory rheumatic disorder that occurs in patients with psoriasis and predominantly affects musculoskeletal structures, skin, and nails. The etiology of PsA is not well understood but evidence supports an interplay of genetic, immunologic, and environmental factors which promote pathological bone remodeling and joint damage in PsA. Localized and systemic bone loss due to increased activity of osteoclasts is well established in PsA based on animal models and translational studies...
January 12, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29330358/pathogenesis-of-bone-disease-in-multiple-myeloma-from-bench-to-bedside
#4
REVIEW
Evangelos Terpos, Ioannis Ntanasis-Stathopoulos, Maria Gavriatopoulou, Meletios A Dimopoulos
Osteolytic bone disease is the hallmark of multiple myeloma, which deteriorates the quality of life of myeloma patients, and it affects dramatically their morbidity and mortality. The basis of the pathogenesis of myeloma-related bone disease is the uncoupling of the bone-remodeling process. The interaction between myeloma cells and the bone microenvironment ultimately leads to the activation of osteoclasts and suppression of osteoblasts, resulting in bone loss. Several intracellular and intercellular signaling cascades, including RANK/RANKL/OPG, Notch, Wnt, and numerous chemokines and interleukins are implicated in this complex process...
January 12, 2018: Blood Cancer Journal
https://www.readbyqxmd.com/read/29329805/preparative-expression-and-purification-of-a-nacreous-protein-n16-and-testing-its-effect-on-osteoporosis-rat-model
#5
Zhen-Yan Xu, Yu-Ling Liu, Jia-Bi Lin, Ke-Ling Cheng, Yong-Gang Wang, Hong-Liang Yao, Wei-Peng, Hoi-Yan Wu, Wei-Wei Su, Pang-Chui Shaw, Pei-Bo Li
N16, a nacreous protein isolated from Pinctada martensii, is related to nacreous layer formation. Our previous study indicated that N16 showed dual regulatory effects by inducing osteoblast biomineralization as well as inhibiting osteoclast formation. In order to obtain large quantity of N16 for animal experiment and clinical trial, a fermentation and preparative purification method was established. The N16 cDNA was cloned to a BL21(DE3)plysE-pET32a vector and grown in a 20 L fermenter. The medium, temperature, pH and dissolved oxygen (DO) were optimized...
January 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29329716/gelatin-hydroxyapatite-calcium-sulphate-based-biomaterial-for-long-term-sustained-delivery-of-bone-morphogenic-protein-2-and-zoledronic-acid-for-increased-bone-formation-in-vitro-and-in-vivo-carrier-properties
#6
Deepak Bushan Raina, David Larsson, Filip Mrkonjic, Hanna Isaksson, Ashok Kumar, Lars Lidgren, Magnus Tägil
In this study, a novel macroporous composite biomaterial consisting of gelatin-hydroxyapatite-calcium sulphate for delivery of bone morphogenic protein-2 (rhBMP-2) and zoledronic acid (ZA) has been developed. The biomaterial scaffold has a porous structure and functionalization of the scaffold with rhBMP-2 induces osteogenic differentiation of MC3T3-e1 cells seen by a significant increase in biochemical and genetic markers of osteoblastic differentiation. In-vivo muscle pouch experiments showed higher mineralization using scaffold+rhBMP-2 when compared to an approved absorbable collagen sponge (ACS)+rhBMP-2 as verified by micro-CT...
January 9, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29328370/ammonium-tetrathiomolybdate-enhances-the-antitumor-effects-of-cetuximab-via-the-suppression-of-osteoclastogenesis-in-head-and-neck-squamous-carcinoma
#7
Ayaka Morisawa, Tatsuo Okui, Tsuyoshi Shimo, Soichiro Ibaragi, Yuka Okusha, Mitsuaki Ono, Thi Thu Ha Nguyen, Nur Mohammad Monsur Hassan, Akira Sasaki
Head and neck squamous cell carcinoma (HNSCC) poses a significant challenge clinically where one of the mechanisms responsible for the invasion into facial bones occurs via the activation of osteoclasts. Copper has been demonstrated to play a key role in skeletal remodeling. However, the role of copper in cancer-associated bone destruction is thus far unknown. Lysyl oxidase (LOX) is a copper-dependent enzyme that promotes osteoclastogenesis. In the present study, we investigated the effects of copper on HNSCC with bone invasion by the copper chelator, ammonium tetrathiomolybdate (TM) in vitro and in vivo...
January 10, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29323724/autoregulation-of-rank-ligand-in-oral-squamous-cell-carcinoma-tumor-cells
#8
Yuvaraj Sambandam, Purushoth Ethiraj, Jessica Hathway-Schrader, Chad Novince, Ezhil Panneerselvam, Kumaran Sundaram, Sakamuri V Reddy
Oral squamous cell carcinoma (OSCC) is the most common malignancy among oral cancers and shows potent activity for local bone invasion. Receptor activator of nuclear factor κB (RANK) ligand (RANKL) is critical for bone-resorbing osteoclast formation. We previously demonstrated that OSCC tumor cells express high levels of RANKL. In this study, confocal microscopy demonstrated RANKL specific receptor, RANK expression in OSCC tumor cell lines (SCC1, SCC12 and SCC14a). We also confirmed the expression of RANK and RANKL in primary human OSCC tumor specimens...
January 11, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29323204/calcium-phosphate-complex-increased-during-subchondral-bone-remodeling-affects-earlystage-osteoarthritis
#9
Youn-Kwan Jung, Min-Su Han, Hye-Ri Park, Eun-Ju Lee, Ji-Ae Jang, Gun-Woo Kim, Sun-Young Lee, DaeWon Moon, Seungwoo Han
An activation of osteoclasts and subchondral bone remodeling is a major histologic feature of early-stage osteoarthritis (OA), which can be accompanied by an increase of calcium (Ca) and phosphate (Pi) level in the subchondral milieu. Considering articular cartilage gets most of nutrition from subchondral bone by diffusion, these micro-environmental changes in subchondral bone can affect the physiology of articular chondrocytes. Here, we have shown that Ca is increased and co-localized with Pi in articular cartilage of early-stage OA...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29323185/biogenesis-of-podosome-rosettes-through-fission
#10
Szu-Lin Kuo, Chien-Lin Chen, Yi-Ru Pan, Wen-Tai Chiu, Hong-Chen Chen
Podosomes are dynamic actin-based membrane protrusions that are important for extracellular matrix degradation and invasive cell motility. Individual podosomes are often found to organize into large rosette-like structures in some types of cells, such as osteoclasts, endothelial cells, Src-transformed fibroblasts, and certain highly invasive cancer cells. In this study, we show that new podosome rosettes arise through one of two mechanisms; de novo assembly or fission of a pre-existing podosome rosette in Src-transformed fibroblasts...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29322325/histochemical-evidence-of-igf2-mrna-binding-protein-2-mediated-regulation-of-osteoclast-function-and-adhesive-ability
#11
Hongrui Liu, Dongfang Li, Shanshan Liu, Zhaopeng Liu, Minqi Li
Insulin-like growth factor 2 (IGF2) messenger RNA-binding proteins (IMPs) are a family of oncofetal RNA-binding proteins that play important roles in cell migration, renewal, and metabolism. IMP2 gene expression may be important in determining IGF2 levels and might, thereby, be central to bone metabolism. In our present study, IMP2-deficient mice exhibited more immature bone structures, characterized by abundant residual cartilage cores; growth plates containing more rich cartilage matrix, which was arranged irregularly; and a significantly thicker hypertrophic chondrocyte layer in the femoral metaphysis, compared with wild-type mice...
January 10, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29321503/il-34-and-csf-1-display-an-equivalent-macrophage-differentiation-ability-but-a-different-polarization-potential
#12
Sonia Boulakirba, Anja Pfeifer, Rana Mhaidly, Sandrine Obba, Michael Goulard, Thomas Schmitt, Paul Chaintreuil, Anne Calleja, Nathan Furstoss, François Orange, Sandra Lacas-Gervais, Laurent Boyer, Sandrine Marchetti, Els Verhoeyen, Frederic Luciano, Guillaume Robert, Patrick Auberger, Arnaud Jacquel
CSF-1 and IL-34 share the CSF-1 receptor and no differences have been reported in the signaling pathways triggered by both ligands in human monocytes. IL-34 promotes the differentiation and survival of monocytes, macrophages and osteoclasts, as CSF-1 does. However, IL-34 binds other receptors, suggesting that differences exist in the effect of both cytokines. In the present study, we compared the differentiation and polarization abilities of human primary monocytes in response to CSF-1 or IL-34. CSF-1R engagement by one or the other ligands leads to AKT and caspase activation and autophagy induction through expression and activation of AMPK and ULK1...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29321271/incremental-distribution-of-strontium-and-zinc-in-great-ape-and-fossil-hominin-cementum-using-synchrotron-x-ray-fluorescence-mapping
#13
Christopher Dean, Adeline Le Cabec, Kathryn Spiers, Yi Zhang, Jan Garrevoet
Cementum and the incremental markings it contains have been widely studied as a means of ageing animals and retrieving information about diet and nutrition. The distribution of trace elements in great ape and fossil hominin cementum has not been studied previously. Synchrotron X-ray fluorescence (SXRF) enables rapid scanning of large tissue areas with high resolution of elemental distributions. First, we used SXRF to map calcium, phosphorus, strontium and zinc distributions in great ape dentine and cementum...
January 2018: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29318411/cyclophilin-a-increases-cd68-cell-infiltration-in-rat-experimental-periodontitis
#14
Lande Xue, Linwang Su, Li Zhao, Jianxia Li, Yi Du, Xijiao Yu
Cyclophilin A (CyPA) is a potent chemokine, which can directly induce leukocyte chemotaxis and contribute to the pathogenesis of inflammation-mediated diseases. This study is to observe the expression and distribution of CyPA and CD68+ cells in the histopathogenesis of rat ligation-induced experimental periodontitis, and assess the role of CyPA in CD68+ cell infiltration in rat experimental periodontitis. Experimental periodontitis was induced by ligation according to our previous method. CyPA expression in gingival tissues was detected by western blotting...
January 9, 2018: Journal of Molecular Histology
https://www.readbyqxmd.com/read/29317302/bu-shen-tong-luo-decoction-prevents-bone-loss-via-inhibition-of-bone-resorption-and-enhancement-of-angiogenesis-in-ovariectomy-induced-osteoporosis-of-rats
#15
Han Yuan, Linyan Xiao, Wen Min, Wenchao Yuan, Shengfeng Lu, Guicheng Huang
ETHNOPHARMACOLOGICAL RELEVANCE: Gathering three ancient formulas, traditional Chinese medicine Bu-Shen-Tong-Luo decoction (BSTLD) has been used to treat postmenopausal osteoporosis (PMO) at the Jiangsu Province Hospital of Chinese Medicine for decades. However, the effect of BSTLD on angiogenesis and bone resorption as well as its possible mechanism are still unknown. AIM OF THE STUDY: This study was aimed to evaluate the preventive effect of BSTLD on ovariectomy-induced bone loss and vasculature disorder, and to investigate the possible bone protection mechanism of BSTLD in inhibiting bone resorption by enhancing angiogenesis signaling in ovariectomy-induced osteoporosis of rats...
January 6, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29316231/osteogenic-cellular-activity-around-onlaid-octacalcium-phosphate-gelatin-composite-onto-rat-calvaria
#16
Ryosuke Iwama, Takahisa Anada, Yukari Shiwaku, Kaori Tsuchiya, Tetsu Takahashi, Osamu Suzuki
The activity and the distribution of osteogenic cells around octacalcium phosphate (OCP) granules combined with gelatin matrix (OCP/Gel) onlaid on rat calvaria were analyzed histomorphometrically and immunohistochemically during vertical bone augmentation under mechanical or non-mechanical environment until 8 weeks. OCP/Gel disk was placed in subperiosteal pocket on the calvaria with or without polytetrafluoroethylene (PTFE) support. The latter is a non-mechanical stress model to alleviate the mechanical stress from the subcutaneous tissues...
January 9, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29316218/local-administration-of-nuclear-factor-of-activated-t-cells-nfat-c1-inhibitor-to-suppress-early-resorption-and-inflammation-induced-by-bone-morphogenetic-protein-2
#17
Ri Youn Kim, Yeju Seong, Tae Hyung Cho, Beomseok Lee, In Sook Kim, Soon Jung Hwang
Nuclear factor of activated T cells (NFAT)-c1 is known as a key regulator in osteoclast differentiation and immune response. This study is a follow-up to our previous study showing the anti-resorptive activity of VIVIT, a peptide type NFATc1 inhibitor, using absorbable collagen sponge (ACS). This study aimed to investigate the effective concentration range of local VIVIT that suppresses early excessive osteoclast activation and inflammation induced by high-dose recombinant human bone morphogenetic protein (rhBMP)-2 and concomitantly enhances bone healing in a rat critical-sized calvaria defect model...
January 9, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29314205/cdc42-is-essential-for-both-articular-cartilage-degeneration-and-subchondral-bone-deterioration-in-experimental-osteoarthritis
#18
Xinhua Hu, Xing Ji, Mengting Yang, Shihao Fan, Jirong Wang, Meiping Lu, Wei Shi, Liu Mei, Chengyun Xu, Xueying Fan, Musaddique Hussain, Jingyu Du, Junsong Wu, Ximei Wu
Cdc42, a member of Rho family small GTPases, is critical for cartilage development. We investigated the roles of Cdc42 in osteoarthritis and explored the potential mechanism underlying Cdc42-mediated articular cartilage degeneration and subchondral bone deterioration. Cdc42 is highly expressed in both articular cartilage and subchondral bone in a mouse osteoarthritis model with surgical destabilisation of the medial meniscus (DMM) in the knee joints. Specifically, genetic disruption of Cdc42, knockdown of Cdc42 expression, or inhibition of Cdc42 activity robustly attenuates the DMM-induced destruction, hypertrophy, high expression of matrix metallopeptidase-13 and collagen X, and activation of Stat3 in articular cartilages...
January 3, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29311633/traf2-in-osteotropic-breast-cancer-cells-enhances-skeletal-tumour-growth-and-promotes-osteolysis
#19
Prabha Peramuhendige, Silvia Marino, Ryan T Bishop, Daniëlle de Ridder, Asim Khogeer, Isabella Baldini, Mattia Capulli, Nadia Rucci, Aymen I Idris
NFκB plays an important role in inflammation and bone remodelling. Tumour necrosis factor receptor associated factor 2 (TRAF2), a key component of NFκB signalling, has been identified as an oncogene, but its role in the regulation of breast cancer osteolytic metastasis remains unknown. Here, we report that stable overexpression of TRAF2 in parental and osteotropic sub-clones of human MDA-MB-231 (MDA-231) breast cancer cells increased cell growth and motility in vitro, whereas TRAF2 knockdown was inhibitory...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29306659/breast-osteoblast-like-cells-a-reliable-early-marker-for-bone-metastases-from-breast-cancer
#20
Manuel Scimeca, Chiara Antonacci, Nicola Toschi, Elena Giannini, Rita Bonfiglio, Claudio Oreste Buonomo, Chiara Adriana Pistolese, Umberto Tarantino, Elena Bonanno
BACKGROUND: The development of bone metastasis from breast cancer results from a functional interaction between tumor cells and osteoclasts or osteoblasts. The main aim of this study was therefore to test the hypothesis that the appearance of breast osteoblast-like cells (BOLCs) in primary mammary lesions is a precursor (and hence an early predictor) of the formation of breast cancer metastases to bone. PATIENTS AND METHODS: In this study, we collected 64 breast infiltrating carcinomas, 50 breast benignant lesions, and 10 biopsies of bone metastasis selected from patients with infiltrated carcinoma...
December 5, 2017: Clinical Breast Cancer
keyword
keyword
76833
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"