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https://www.readbyqxmd.com/read/28652172/enhancement-and-inhibition-effects-on-the-corneal-permeability-of-timolol-maleate-polymers-cyclodextrins-and-chelating-agents
#1
Isabel Rodriguez, José Antonio Vázquez, Lorenzo Pastrana, Vitaliy V Khutoryanskiy
This study investigates how both bioadhesive polymers (chitosan, hyaluronic acid and alginate) and permeability enhancers (ethylene glycol- bis(2-aminoethylether)- N, N, N', N'- tetraacetic acid (EGTA) and hydroxypropyl-ß-cyclodextrin) influence the permeability of the anti-glaucoma drug timolol maleate through ex vivo bovine corneas. Our results showed that only the permeability enhancers alone were able to increase drug permeability, whereas the polymers significantly reduced drug permeation, and however, they increased the pre-corneal residence of timolol...
June 23, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28650092/photoactivatable-mussel-based-underwater-adhesive-proteins-by-an-expanded-genetic-code
#2
Mathias Hauf, Florian Richter, Tobias Schneider, Thomas Faidt, Berta M Martins, Tobias Baumann, Patrick Durkin, Holger Dobbek, Karin Jacobs, Andreas Möglich, Nediljko Budisa
Marine mussels exhibit potent underwater adhesion abilities under hostile conditions employing 3,4-dihydroxy-phenylalanine (Dopa)-rich mussel-adhesive proteins (MAPs). However, their recombinant production is a major biotechnological challenge. Here, we have developed a novel strategy based on genetic code expansion by engineering efficient aminoacyl-tRNA synthetases (aaRSs) for the photocaged non-canonical amino acid (ncAA) ortho-nitrobenzyl Dopa (ONB-Dopa). The engineered ONB-DopaRS enables in vivo production of MAP type 5 site-specifically equipped with multiple instances of ONB-Dopa yielding spatiotemporally controlled underwater adhesives...
June 26, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28638787/bioadhesive-bacterial-microswimmers-for-targeted-drug-delivery-in-the-urinary-and-gastrointestinal-tracts
#3
Babak Mostaghaci, Oncay Yasa, Jiang Zhuang, Metin Sitti
Bacteria-driven biohybrid microswimmers (bacteriabots), which integrate motile bacterial cells and functional synthetic cargo parts (e.g., microparticles encapsulating drug), are recently studied for targeted drug delivery. However, adhesion of such bacteriabots to the tissues on the site of a disease (which can increase the drug delivery efficiency) is not studied yet. Here, this paper proposes an approach to attach bacteriabots to certain types of epithelial cells (expressing mannose on the membrane), based on the affinity between lectin molecules on the tip of bacterial type I pili and mannose molecules on the epithelial cells...
June 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28615944/the-interactions-of-single-wall-carbon-nanohorns-with-polar-epithelium
#4
Yujie Shi, Zujin Shi, Suxin Li, Yuan Zhang, Bing He, Dong Peng, Jie Tian, Ming Zhao, Xueqing Wang, Qiang Zhang
Single-wall carbon nanohorns (SWCNHs), which have multitudes of horn interstices, an extensive surface area, and a spherical aggregate structure, offer many advantages over other carbon nanomaterials being used as a drug nanovector. The previous studies on the interaction between SWCNHs and cells have mostly emphasized on cellular uptake and intracellular trafficking, but seldom on epithelial cells. Polar epithelium as a typical biological barrier constitutes the prime obstacle for the transport of therapeutic agents to target site...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28614950/grafting-of-architecture-controlled-poly-styrene-sodium-sulfonate-onto-titanium-surfaces-using-bio-adhesive-molecules-surface-characterization-and-biological-properties
#5
Hamza Chouirfa, Margaret D M Evans, David G Castner, Penny Bean, Dimitri Mercier, Anouk Galtayries, Céline Falentin-Daudré, Véronique Migonney
This contribution reports on grafting of bioactive polymers such as poly(sodium styrene sulfonate) (polyNaSS) onto titanium (Ti) surfaces. This grafting process uses a modified dopamine as an anchor molecule to link polyNaSS to the Ti surface. The grafting process combines reversible addition-fragmentation chain transfer polymerization, postpolymerization modification, and thiol-ene chemistry. The first step in the process is to synthetize architecture controlled polyNaSS with a thiol end group. The second step is the adhesion of the dopamine acrylamide (DA) anchor onto the Ti surfaces...
June 14, 2017: Biointerphases
https://www.readbyqxmd.com/read/28599154/the-importance-of-the-relationship-between-mechanical-analyses-and-rheometry-of-mucoadhesive-thermoresponsive-polymeric-materials-for-biomedical-applications
#6
Sabrina Barbosa De Souza Ferreira, Jéssica Bassi Da Silva, Mariana Volpato Junqueira, Fernanda Belincanta Borghi-Pangoni, Raquel Guttierres Gomes, Marcos Luciano Bruschi
Pluronic F127(®) was associated with a carbomer homopolymer type B, as a model polymer blend to evidence the information provided by rheological and mechanical analyses on the development of bioadhesive thermoresponsive systems. The mechanical analysis enabled to observe that 20% (w/w) Pluronic F127(®)-polymer blends were harder, more adhesive, more mucoadhesive, more compressive and less soft. In addition, continuous flow rheometry demonstrated that the systems were plastic with rheopexy (15%, w/w, Pluronic F127(®)) or thixotropic (20%, w/w, Pluronic F127(®))...
June 2, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28597123/vaginal-drug-delivery-for-the-localised-treatment-of-cervical-cancer
#7
REVIEW
Ian Major, Christopher McConville
Cervical cancer is usually treated by surgery, with the more advanced cancers requiring adjuvant chemotherapy or radiotherapy. The location of the cervix makes it easily accessible through the vagina for the localised delivery of chemotherapeutic drugs. Localised delivery has the advantage of direct delivery to the site of action resulting in a lower dose having to be required and a reduction in systemic side effects. This approach would be advantageous for fertility sparing surgery, whereby localised delivery could be used to reduce tumour size allowing for a much smaller tumour to be removed, reducing the risk of preterm birth...
June 8, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28579065/engineering-a-sprayable-and-elastic-hydrogel-adhesive-with-antimicrobial-properties-for-wound-healing
#8
Nasim Annabi, Devyesh Rana, Ehsan Shirzaei Sani, Roberto Portillo-Lara, Jessie L Gifford, Mohammad M Fares, Suzanne M Mithieux, Anthony S Weiss
Hydrogel-based bioadhesives have emerged as alternatives for sutureless wound closure, since they can mimic the composition and physicochemical properties of the extracellular matrix. However, they are often associated with poor mechanical properties, low adhesion to native tissues, and lack of antimicrobial properties. Herein, a new sprayable, elastic, and biocompatible composite hydrogel, with broad-spectrum antimicrobial activity, for the treatment of chronic wounds is reported. The composite hydrogels were engineered using two ECM-derived biopolymers, gelatin methacryloyl (GelMA) and methacryloyl-substituted recombinant human tropoelastin (MeTro)...
September 2017: Biomaterials
https://www.readbyqxmd.com/read/28578189/photoactivatable-fluorescent-probes-reveal-heterogeneous-nanoparticle-permeation-through-biological-gels-at-multiple-scales
#9
Benjamin S Schuster, Daniel B Allan, Joshua C Kays, Justin Hanes, Robert L Leheny
Diffusion through biological gels is crucial for effective drug delivery using nanoparticles. Here, we demonstrate a new method to measure diffusivity over a large range of length scales - from tens of nanometers to tens of micrometers - using photoactivatable fluorescent nanoparticle probes. We have applied this method to investigate the length-scale dependent mobility of nanoparticles in fibrin gels and in sputum from patients with cystic fibrosis (CF). Nanoparticles composed of poly(lactic-co-glycolic acid), with polyethylene glycol coatings to resist bioadhesion, were internally labeled with caged rhodamine to make the particles photoactivatable...
May 31, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28571541/investigation-of-methylene-blue-release-from-functional-polymeric-systems-using-dielectric-analysis
#10
Marcos Luciano Bruschi, Mariana Volpato Junqueira, Fernanda Belincanta Borghi-Pangoni, Tao Yu, Gavin Paul Andrews, David Simon Jones
BACKGROUND: Methylene blue (MB) is a photosensitizer used in photodynamic therapy (PDT) to treat colorectal cancer tumors and leishmaniasis infection. The clinical efficacy of PDT using MB is dependent on the physicochemical characteristics of the formulation. Bioadhesive thermoresponsive systems containing poloxamer 407 and Carbopol 934P have been proposed as platforms for PDT. However, the effect of MB on the physicochemical properties of these platforms is not fully understood, particularly in light of the MB availability...
June 1, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28551363/salamanders-on-the-bench-a-biocompatibility-study-of-salamander-skin-secretions-in-cell-cultures
#11
Janek von Byern, Dietrich Mebs, Egon Heiss, Ursula Dicke, Oliver Wetjen, Kristin Bakkegard, Ingo Grunwald, Susanne Wolbank, Severin Mühleder, Alfred Gugerell, Heidemarie Fuchs, Sylvia Nürnberger
Salamanders have evolved a wide variety of antipredator mechanisms and behavior patterns, including toxins and noxious or adhesive skin secretions. The high bonding strength of the natural bioadhesives makes these substances interesting for biomimetic research and applications in industrial and medical sectors. Secretions of toxic species may help to understand the direct effect of harmful substances on the cellular level. In the present study, the biocompatibility of adhesive secretions from four salamander species (Plethodon shermani, Plethodon glutinosus, Ambystoma maculatum, Ambystoma opacum) were analyzed using the MTT assay in cell culture and evaluated against toxic secretions of Pleurodeles waltl, Triturus carnifex, Pseudotriton ruber, Tylototriton verrucosus, and Salamandra salamandra...
May 25, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28546953/perspective-highlights-on-biodegradable-polymeric-nanosystems-for-targeted-therapy-of-solid-tumors
#12
REVIEW
Marziyeh Fathi, Jaleh Barar
Introduction: Polymeric nanoparticles (NPs) formulated using biodegradable polymers offer great potential for development of de novo drug delivery systems (DDSs) capable of delivering a wide range of bioactive agents. They can be engineered as advanced multifunctional nanosystems (NSs) for simultaneous imaging and therapy known as theranostics or diapeutics. Methods: A brief prospective is provided on biomedical importance and applications of biodegradable polymeric NSs through reviewing the recently published literature...
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/28544261/mechanical-properties-structure-bioadhesion-and-biocompatibility-of-pectin-hydrogels
#13
Pavel A Markov, Nikita S Krachkovsky, Eugene A Durnev, Ekaterina A Martinson, Sergey G Litvinets, Sergey V Popov
The surface structure, biocompatibility, textural, and adhesive properties of calcium hydrogels derived from 1, 2, and 4% solutions of apple pectin were examined in this study. An increase in the pectin concentration in hydrogels was shown to improve their stability toward elastic and plastic deformation. The elasticity of pectin hydrogels, measured as Young's modulus, ranged from 6 to 100 kPa. The mechanical properties of the pectin hydrogels were shown to correspond to those of soft tissues. The characterization of surface roughness in terms of the roughness profile (Ra) and the root-mean-square deviation of the roughness profile (Rq) indicated an increased roughness profile for hydrogels depending on their pectin concentration...
May 22, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28539275/mucosal-transfer-of-wheat-germ-agglutinin-modified-lipid-polymer-hybrid-nanoparticles-for-oral-delivery-of-oridonin
#14
Ying Liu, Jinguang Liu, Jun Liang, Meiying Zhang, Zhe Li, Zhi Wang, Beilei Dang, Nianping Feng
Wheat germ agglutinin-modified lipid-polymer hybrid nanoparticles (WGA-LPNs) promote cellular uptake after oral delivery via receptor-mediated endocytosis and bioadhesion. Understanding the mucosal transport of WGA-LPNs would help to improve bioavailability and ensure therapeutic efficacy. In this study, WGA-LPNs interacted with mucin, forming larger agglomerates with intact core-shell structure. The interaction of WGA-LPNs with mucin improved enterocyte endocytosis in Caco-2 cells. An in situ intestinal diffusion study in mice confirmed that WGA-LPNs reached enterocytes and underwent endocytosis, despite interference from mucin...
May 21, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28516414/optimized-mucoadhesive-coated-niosomes-as-a-sustained-oral-delivery-system-of-famotidine
#15
Al-Zahraa M Khalifa, Bazigha K Abdul Rasool
The objective of this study is to develop an oral formulation of famotidine niosomes coated with a mucoadhesive polymer, chitosan. Famotidine (FMT) has low oral bioavailability of 40-45% and short half-life between 2.5 to 4 h. Famotidine is classified as class IV in BCS because of its low aqueous solubility (0.1% w/v) and low permeability. Thus, FMT was loaded to the bioadhesive coated niosomes to improve its solubility, enhance its oral bioavailability, and sustain FMT release pattern. Different formulations were prepared by thin-film hydration method and characterized in terms of entrapment efficiency, morphological features, vesicle size, and zeta potential...
May 17, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28512660/selective-protein-recognition-in-supported-lipid-bilayer-arrays-by-tailored-dual-mode-deep-cavitand-hosts
#16
Lizeth Perez, Magi Mettry, Samuel S Hinman, Samantha R Byers, Kristy S McKeating, Bethany G Caulkins, Quan Cheng, Richard J Hooley
Self-folding deep cavitands with variably functionalized upper rims are able to selectively immobilize proteins at a biomimetic supported lipid bilayer surface. The immobilization process takes advantage of the dual-mode binding capabilities of the hosts, combining a defined binding pocket with upper rim charged/H-bonding groups. A variety of proteins can be selectively immobilized at the bilayer interface, either via complementary charge/H-bonding interactions, cavity-based molecular recognition, or a combination of both...
May 31, 2017: Soft Matter
https://www.readbyqxmd.com/read/28506801/old-drug-new-wrapping-a-possible-comeback-for-chloramphenicol
#17
Sveinung G Ingebrigtsen, Alena Didriksen, Mona Johannessen, Nataša Škalko-Basnet, Ann Mari Holsæter
The antimicrobial drug chloramphenicol (CAM) exhibits activity against resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). However, its use has been limited due to its toxicity. As the threat of antibiotic resistance continues to grow, a promising approach might be to increase the use of historical antimicrobial agents that demonstrate clinical efficacy, but are hampered by toxicity. We therefore aimed to prepare a liposome-in-hydrogel system for dermal delivery of CAM. Chitosan (CS) was used as the hydrogel vehicle due to its antimicrobial activity and excellent biocompatibility...
May 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28482609/combining-nt3-overexpressing-mscs-and-plga-microcarriers-for-brain-tissue-engineering-a-potential-tool-for-treatment-of-parkinson-s-disease
#18
Hanieh Moradian, Hamid Keshvari, Hamidreza Fasehee, Rassoul Dinarvand, Shahab Faghihi
Parkinson's disease (PD) is a progressive neurodegenerative disorder that characterized by destruction of substantia nigrostriatal pathway due to the loss of dopaminergic (DA) neurons. Regardless of substantial efforts for treatment of PD in recent years, an effective therapeutic strategy is still missing. In a multidisciplinary approach, bone marrow derived mesenchymal stem cells (BMSCs) are genetically engineered to overexpress neurotrophin-3 (nt-3 gene) that protect central nervous system tissues and stimulates neuronal-like differentiation of BMSCs...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28467734/structural-heteropolysaccharide-adhesion-to-the-glycocalyx-of-visceral-mesothelium
#19
Andrew Servais, Arne Kienzle, Cristian D Valenzuela, Alexandra B Ysasi, Willi L Wagner, Akira Tsuda, Maximilian Ackermann, Steven J Mentzer
Bioadhesives are biopolymers with potential applications in wound healing, drug delivery, and tissue engineering. Pectin, a plant-based heteropolysaccharide, has recently demonstrated potential as a mucoadhesive in the gut. Since mucoadhesion is a process likely involving the interpenetration of the pectin polymer with mucin chains, we hypothesized that pectin may also be effective at targeting the glycocalyx of visceral mesothelium. To explore the potential role of pectin as a mesothelial bioadhesive, we studied the interaction of various pectin formulations with the mesothelium of the lung, liver, bowel and heart...
May 3, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28462414/superoleophobic-surfaces
#20
REVIEW
Jiale Yong, Feng Chen, Qing Yang, Jinglan Huo, Xun Hou
Superoleophobicity is a phenomenon where the contact angles of various oil droplets with low surface tension on a solid surface are larger than 150°. In the past few years, there has been much growing interest in the design and application of superoleophobic surfaces. Such surfaces have great significance for both fundamental research and a variety of practical applications, including oil-repellent coatings, self-cleaning, oil/water separation, oil droplet manipulation, chemical shielding, anti-blocking, designing liquid microlens, oil capture, bioadhesion, guiding oil movement and floating on oil...
May 2, 2017: Chemical Society Reviews
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