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https://www.readbyqxmd.com/read/29470387/assessment-of-chitosan-based-hydrogel-and-photodynamic-inactivation-against-propionibacterium-acnes
#1
Maria Lucia Frade, Sarah Raquel de Annunzio, Giovana Maria Fioramonti Calixto, Francesca Damiani Victorelli, Marlus Chorilli, Carla Raquel Fontana
Chitosan (CH) is a biopolymer that exhibits a number of interesting properties such as anti-inflammatory and antibacterial activity and is also a promising platform for the incorporation of photosensitizing agents. This study aimed to evaluate the efficacy of antimicrobial activity of chitosan hydrogel formulation alone and in combination with the methylene blue (MB) associated with antimicrobial photodynamic therapy (aPDT) against planktonic and biofilm phase of Propionibacterium acnes . Suspensions were sensitized with 12...
February 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29463380/metronidazole-loaded-polyethyleneimine-and-chitosan-based-liquid-crystalline-system-for-treatment-of-staphylococcal-skin-infections
#2
Francesca Damiani Victorelli, Giovana Maria Fioramonti Calixto, Matheus Aparecido Dos Santos Ramos, Taís Maria Bauab, Marlus Chorilli
Staphylococcus aureus is a common gram-positive bacterium of the human skin microbiota. It is also a dangerous pathogen that can cause serious and even lethal skin infections. The topical administration of metronidazole via nanotechnology-based drug delivery systems, such as liquid crystalline systems, can modulate both the drug permeation and activity, decreasing its side effects and increasing the drug potent activity against the gram-positive bacteria. This study aimed at: (1) structurally developing and characterizing a liquid crystalline systems composed of chitosan and polyethyleneimine dispersion as the aqueous phase, oleic acid as the oily phase, and ethoxylated and propoxylated cetyl alcohol as the surfactant (FPC) for metronidazole incorporation (0...
January 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29462781/tripolyphosphate-crosslinked-chitosan-poly-ethylene-oxide-electrospun-nanofibrous-mats-as-a-floating-gastro-retentive-delivery-system-for-ranitidine-hydrochloride
#3
Behzad Darbasizadeh, Hamidreza Motasadizadeh, Behrouz Foroughi-Nia, Hassan Farhadnejad
The present study describes the fabrication of Tripolyphosphate (TPP)-crosslinked nanofibrous mats based on chitosan for use as a floating gastro-retentive delivery system. TPP-crosslinked chitosan (CH)/poly (ethylene oxide) (PEO)- ranitidine hydrochloride (RH) electrospun nanofibers (75.27 ± 2.10 nm) were prepared by electrospinning 70% v/v acetic acid solutions, and followed by crosslinking by TPP anions. The mechanical, structural and morphological properties of the prepared nanofibers were evaluated via tensile testing, XRD, FT-IR, TGA, NMR, AFM and SEM experimental techniques...
February 11, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29457454/rationally-designed-multifunctional-self-assembled-nanoparticles-for-covalently-networked-flexible-and-self-healable-superhydrophobic-composite-films
#4
Yujin Lee, Eun-Ah You, Young-Geun Ha
For constructing bio-inspired functional films with various superhydrophobic functions including self-cleaning, anti-corrosion, anti-bioadhesion, and oil-water separation, hydrophobic nanomaterials have been widely used as crucial structural components. In general, hydrophobic nanomaterials, however, cannot form strong chemical bond networks in organic-inorganic hybrid composite films because of the absence of chemically compatible binding components. Herein, we report the rationally designed, multifunctional self-assembled nanoparticles with tunable functionalities of covalent cross-linking and hydrophobicity for constructing three-dimensionally interconnected superhydrophobic composite films via a facile solution-based fabrication at room temperature...
February 19, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29435550/functional-amyloid-materials-at-surfaces-interfaces
#5
Chen Li, Rongrong Qin, Ruirui Liu, Shuting Miao, Peng Yang
With the development of nanotechnology, functional amyloid materials are drawing increasing attention, and numerous remarkable applications are emerging. Amyloids, defined as a class of supramolecular assemblies of misfolded proteins or peptides into β-sheet fibrils, have evolved in many new respects and offer abundant chemical/biological functions. These proteinaceous micro/nano-structures provide excellent biocompatibility, rich phase behaviours, strong mechanical properties, and stability at interfaces not only in nature but also in functional materials, displaying versatile interactions with surfaces/interfaces that have been widely adopted in bioadhesion, synthetic biology, and composites...
February 13, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29429379/formulation-development-and-evaluation-of-nifedipine-as-pylorospasm-inhibitor
#6
Shaheen Sultana, Sushma Talegaonkar, Bhaskar Ray, Harvinder Singh, F J Ahmad, Gaurav Mittal, Aseem Bhatnagar
INTRODUCTION: In this study, different nifedipine-loaded formulations were prepared to treat pylorospasm, a sphincter muscle disorder characterized by delayed gastric emptying process. The efficacy of formulation was evaluated in patients by subjective assessment, gamma scintigraphic approaches, and confocal microscopy. METHODS: Nifedipine-loaded different formulations such as sucrose bead, pellets, and microparticles (slugging method, ionotropic gelation, and chemical denaturation) were designed...
February 21, 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29425441/non-thrombogenic-hydrogel-coatings-with-carbene-crosslinking-bioadhesives
#7
Himansu Sekhar Nanda, Ankur Harish Shah, Gautama Wicaksono, Oleksandr Pokholenko, Feng Gao, Ivan Djordjevic, Terry W J Steele
Bioadhesives are a current unmet clinical need for mending of blood contacting soft tissues without inducing thrombosis. Recent development of carbene precursor bioadhesives with the advantages of on-demand curing, tuneable modulus, and wet adhesion have been synthesized by grafting diazirine onto poly (amidoamine) (PAMAM-G5) dendrimers. Herein, the structure activity relationships of platelet adhesion and activation is evaluated for the first time on the cured PAMAM-g-diazirine bioadhesives. Three strategies were employed to prevent healthy human donor platelets from adhering and activating on light cured bioadhesive surfaces: 1) Attenuation of cationic surface charge, 2) anti-fouling composites by incorporating heparin and alginate in uncured formulation, and 3) heparin wash of cured bioadhesive surface...
February 9, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29424292/cross-linked-hyaluronan-films-loaded-with-acetazolamide-cyclodextrin-triethanolamine-complexes-for-glaucoma-treatment
#8
Javier Adrián Calles, Maria Julia Mora, Renée Onnainty, Luis Ignacio Tartara, Gladys Ester Granero, Marcela Raquel Longhi, Yolanda Diebold, Enrique Marcelo Vallés, Santiago Daniel Palma
AIM: This work aimed to design and characterize cross-linked hyaluronic acid-itaconic acid films loaded with acetazolamide-hydroxypropyl β cyclodextrin-triethanolamine complexes. MATERIALS & METHODS: Films were cross-linked with itaconic acid and poly(ethyleneglycol)-diglycidylether. Biopharmaceutical properties were assessed by evaluating in vitro drug release rate, biocompatibility in a human corneal epithelial cell line, bioadhesiveness with pig gastric mucin, in vivo bioadhesion and efficacy...
February 1, 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/29408268/the-development-of-progesterone-loaded-nanofibers-using-pressurized-gyration-a-novel-approach-to-vaginal-delivery-for-the-prevention-of-pre-term-birth
#9
Francis Brako, Bahijja Tolulope Raimi-Abraham, Suntharavathanan Mahalingam, Duncan Q M Craig, Mohan Edirisinghe
Recent evidence has continued to support the applicability of progesterone in preventing preterm birth, hence the development of an appropriate vaginal delivery system for this drug would be of considerable interest. Here, we describe the development of progesterone-loaded bioadhesive nanofibers using pressurized gyration for potential incorporation into a vaginal insert, with a particular view to addressing the challenges of incorporating a poorly water-soluble drug into a hydrophilic nanofiber carrier. Polyethylene oxide and carboxymethyl cellulose were chosen as polymers to develop the carrier systems, based on previous evidence of their yielding mucoadhesive nanofibers using the pressurized gyration technique...
February 2, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29368229/viability-and-biocompatibility-of-an-adhesive-system-for-intrarenal-embedding-and-endoscopic-removal-of-small-residual-fragments-in-minimally-invasive-stone-treatment-in-an-in-vivo-pig-model
#10
Simon Hein, Dominik Stefan Schoeb, Ingo Grunwald, Katharina Richter, Jörg Haberstroh, Maximilian Seidl, Peter Bronsert, Ulrich Wetterauer, Martin Schoenthaler, Arkadiusz Miernik
PURPOSE: To evaluate the viability and biocompatibility of a novel, patented bioadhesive system for intrarenal embedding and retrieval of residual fragments after endoscopic lithotripsy. Complete stone clearance via active removal of residual fragments (RF) after intracorporeal laser lithotripsy may be time-consuming and fail in many cases. Therefore, the novel adhesive has been developed and evaluated for the first time in an in vivo pig model in the present work. METHODS: Four female domestic pigs underwent flexible ureteroscopy (RIRS) or percutaneous nephrolithotomy (PNL) under general anesthesia (8 kidneys, 4 × RIRS, 4 × PNL) evaluating the bioadhesive system...
January 24, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29360239/silicon-carbide-nanoparticles-as-an-effective-bioadhesive-to-bond-collagen-containing-composite-gel-layers-for-tissue-engineering-applications
#11
Rana Attalla, Celine S N Ling, Ponnambalam Ravi Selvaganapathy
Additive manufacturing via layer-by-layer adhesive bonding holds much promise for scalable manufacturing of tissue-like constructs, specifically scaffolds with integrated vascular networks for tissue engineering applications. However, there remains a lack of effective adhesives capable of composite layer fusion without affecting the integrity of patterned features. Here, the use of silicon carbide is introduced as an effective adhesive to achieve strong bonding (0.39 ± 0.03 kPa) between hybrid hydrogel films composed of alginate and collagen...
January 23, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29352936/freeze-dried-chitosan-acetate-dressings-with-glycosaminoglycans-and-traxenamic-acid
#12
Francesca Saporito, Giuseppina Sandri, Silvia Rossi, Maria Cristina Bonferoni, Federica Riva, Lorenzo Malavasi, Carla Caramella, Franca Ferrari
Bleeding control plays an important role to increase survival in the early phase after a traumatic event. The aim of present work was the development of hemostatic sponge-like dressings based on chitosan, in association with glycosaminoglycans (GAG) (chondroitin sulfate or hyaluronic acid) and the improvement of their hemostatic performance by loading tranexamic acid (TA). The dressings were prepared by lyophilizazion and were characterized for mechanical, hydration, bioadhesion properties and morphology. Moreover, FTIR analysis was performed to understand the interactions between the different polyelectrolytes present in the dressings...
March 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29348043/superhydrophobic-coatings-with-high-repellency-to-daily-consumed-liquid-foods-based-on-food-grade-waxes
#13
Xia Zhao, Tao Hu, Junping Zhang
The applications of superhydrophobic coatings in daily life are receiving increasing attention. Here, we report a general approach for preparing superhydrophobic coatings with high repellency to daily consumed liquid foods based on food grade waxes. The coatings are prepared by spray-coating the homogeneous wax suspensions in ethanol followed by annealing at 40 °C. The wax suspensions are formed by the heating dissolution-cooling precipitation-ultrasonication process thanks to the unique solubility of the waxes in ethanol...
January 10, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29343956/essential-oil-loaded-lipid-nanoparticles-for-wound-healing
#14
Francesca Saporito, Giuseppina Sandri, Maria Cristina Bonferoni, Silvia Rossi, Cinzia Boselli, Antonia Icaro Cornaglia, Barbara Mannucci, Pietro Grisoli, Barbara Vigani, Franca Ferrari
Chronic wounds and severe burns are diseases responsible for severe morbidity and even death. Wound repair is a crucial process and tissue regeneration enhancement and infection prevention are key factors to minimize pain, discomfort, and scar formation. The aim of this work was the development of lipid nanoparticles (solid lipid nanoparticles and nanostructured lipid carriers [NLC]), to be loaded with eucalyptus or rosemary essential oils and to be used, as medical devices, to enhance healing of skin wounds...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29331728/the-effect-of-bioadhesive-on-the-interfacial-compatibility-and-pervaporation-performance-of-composite-membranes-by-md-and-gcmc-simulation
#15
Baohe Wang, Yan Nie, Jing Ma
Combing molecular dynamics (MD) and Grand Canonical Monte Carlo (GCMC) simulation, the effect of bioadhesive transition layer on the interfacial compatibility of the pervaporation composite membranes, and the pervaporation performance toward penetrant molecules were investigated. In our previous experimental study, the structural stability and permeability selectivity of the composite membranes were considerably enhanced by the introduction of bioadhesive carbopol (CP). In the present study, the interfacial compatibility and the interfacial energies between the chitosan (CS) separation layer, CP transition layer and the support layer were investigated, respectively...
January 5, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29329807/nasal-adhesive-patches-approach-for-topical-application-for-dry-nasal-syndrome
#16
Flavia Laffleur
This present study intended to provide nasal adhesive formulations for the topical treatment of dry nasal syndrome. Mucoadhesive films were prepared according to solvent evaporation method consisting of well-known polymers such as gellan and carboxymethyl cellulose. Mucoadhesive films (A-E) were evaluated in respect to their physicochemical properties, stability, disintegration behavior and tensile strength. Moreover, uptake capacity of adhesive films was investigated according to three assays vapor uptake/ permeability and water uptake...
January 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29296084/development-and-characterization-of-p1025-loaded-bioadhesive-liquid-crystalline-system-for-the-prevention-of-streptococcus-mutans-biofilms
#17
Giovana Maria Fioramonti Calixto, Cristiane Duque, Kelly Limi Aida, Vanessa Rodrigues Dos Santos, Loiane Massunari, Marlus Chorilli
Formation of a dental biofilm by Streptococcus mutans can cause dental caries, and remains a costly health problem worldwide. Recently, there has been a growing interest in the use of peptidic drugs, such as peptide p1025, analogous to the fragments 1025-1044 of S. mutans cellular adhesin, responsible for the adhesion and formation of dental biofilm. However, peptides have physicochemical characteristics that may affect their biological action, limiting their clinical performance. Therefore, drug-delivery systems, such as a bioadhesive liquid-crystalline system (LCS), may be attractive strategies for peptide delivery...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29288706/improved-vaginal-retention-and-enhanced-antifungal-activity-of-miconazole-microsponges-gel-formulation-development-and-in-vivo-therapeutic-efficacy-in-rats
#18
Salwa Salah, Ghada E A Awad, Amal I A Makhlouf
Traditional azole antifungal formulations suffer from poor retention in the vaginal cavity, irritation and burning of the vaginal area. In the present work, we aim at the development of a novel miconazole (MCZ) microsponges gel as an attractive dosage form for vaginal candidiasis. The proposed formula has the potential to minimize the local side effects of the drug due to the controlled release characteristic, which increases patient compliance. Moreover, the mucosal retention effect of the microsponges in addition to the bioadhesion property of Carbopol gel prolongs the retention of the dosage form in the vagina and consequently improves the therapeutic efficiency...
December 27, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29280278/bioadhesive-polymersome-for-localized-and-sustained-drug-delivery-at-pathological-sites-with-harsh-enzymatic-and-fluidic-environment-via-supramolecular-host-guest-complexation
#19
Meiling Zhu, Kongchang Wei, Sien Lin, Xiaoyu Chen, Chia-Ching Wu, Gang Li, Liming Bian
Targeted and sustained delivery of drugs to diseased tissues/organs, where body fluid exchange and catabolic activity are substantial, is challenging due to the fast cleansing and degradation of the drugs by these harsh environmental factors. Herein, a multifunctional and bioadhesive polycaprolactone-β-cyclodextrin (PCL-CD) polymersome is developed for localized and sustained co-delivery of hydrophilic and hydrophobic drug molecules. This PCL-CD polymersome affords multivalent crosslinking action via surface CD-mediated host-guest interactions to generate a supramolecular hydrogel that exhibits evident shear thinning and efficient self-healing behavior...
December 27, 2017: Small
https://www.readbyqxmd.com/read/29228824/development-of-novel-bioadhesive-granisetron-hydrochloride-spanlastic-gel-and-insert-for-brain-targeting-and-study-their-effects-on-rats
#20
Rehab Abdelmonem, Mohamed El Nabarawi, Alshaimaa Attia
The aim of this study was to formulate granisetron hydrochloride (GH) spanlastic in mucoadhesive gels and lyophilized inserts for intranasal administration to improve GH bioavailability and brain targeting. Carpapol 934 and HPMC were incorporated in GH spanlastic in nasal gels (GHSpNGs). Gelatin and HPMC as matrix former, glycine as a collapse protecting and mannitol as an insert filler and sweeting agent were used to prepare GH spanlastic loaded in lyophilized inserts (GHSpNIs). The prepared GHSpNGs were characterized for pH measurement, drug content, rheology, and in vitro drug release...
November 2018: Drug Delivery
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