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Bioadhesive

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https://www.readbyqxmd.com/read/28207269/a-biocompatible-injectable-hydrogel-with-potent-wound-healing-and-antibacterial-properties
#1
Jiaul Hoque, Relekar G Prakash, Krishnamoorthy Paramanandham, Bibek R Shome, Jayanta Haldar
Two component injectable hydrogels that cross-link in-situ have been used as non-invasive wound-filling devices, i.e., sealants. These materials carry a variety of functions at the wound sites such as seal leaks, cease unwanted bleeding, bind tissues together, and assist in wound healing process. However, commonly used sealants typically lack antibacterial properties. Since bacterial infection at the wound site is very common, bioadhesive materials with intrinsic antibacterial properties are urgently required...
February 16, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28186213/multifunctional-biocompatible-and-ph-responsive-carbon-nanotube-and-graphene-oxide-tectomer-hybrid-composites-and-coatings
#2
Rosa Garriga, Izabela Jurewicz, Shayan Seyedin, Niki Bardi, Stella Totti, Brigitta Matta-Domjan, Eirini G Velliou, Mohammed A Alkhorayef, Vicente L Cebolla, Joselito M Razal, Alan B Dalton, Edgar Muñoz
Here we present a route for non-covalent functionalization of carboxylated multi-walled carbon nanotubes and graphene oxide with novel two-dimensional peptide assemblies. We show that self-assembled amino-terminated biantennary and tetraantennary oligoglycine peptides (referred to as tectomers) effectively coat carboxylated multi-walled carbon nanotubes and also strongly interact with graphene oxide due to electrostatic interactions and hydrogen bonding as the driving force, respectively. The resulting hybrids can be made into free-standing conducting composites or applied in the form of thin, pH-switchable bioadhesive coatings onto graphene oxide fibers...
February 10, 2017: Nanoscale
https://www.readbyqxmd.com/read/28183625/the-design-of-superhydrophobic-stainless-steel-surfaces-by-controlling-nanostructures-a-key-parameter-to-reduce-the-implantation-of-pathogenic-bacteria
#3
Jérôme Bruzaud, Jeanne Tarrade, Elena Celia, Thierry Darmanin, Elisabeth Taffin de Givenchy, Frédéric Guittard, Jean-Marie Herry, Morgan Guilbaud, Marie-Noëlle Bellon-Fontaine
Reducing bacterial adhesion on substrates is fundamental for various industries. In this work, new superhydrophobic surfaces are created by electrodeposition of hydrophobic polymers (PEDOT-F4 or PEDOT-H8) on stainless steel with controlled topographical features, especially at a nano-scale. Results show that anti-bioadhesive and anti-biofilm properties require the control of the surface topographical features, and should be associated with a low adhesion of water onto the surface (Cassie-Baxter state) with limited crevice features at the scale of bacterial cells (nano-scale structures)...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28165805/development-and-characterization-of-polymer-coated-liposomes-for-vaginal-delivery-of-sildenafil-citrate
#4
Hanan Refai, Doaa Hassan, Rehab Abdelmonem
Vaginal administration of sildenafil citrate has shown recently to develop efficiently the uterine lining with subsequent successful embryo implantation following in vitro fertilization. The aim of the present study was to develop sildenafil-loaded liposomes coated with bioadhesive polymers for enhanced vaginal retention and improved drug permeation. Three liposomal formulae were prepared by thin-film method using different phospholipid:cholesterol ratios. The optimal liposomal formulation was coated with bioadhesive polymers (chitosan and HPMC)...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28159519/intracellular-responsive-dual-delivery-by-endosomolytic-polyplexes-carrying-dna-anchored-porous-silicon-nanoparticles
#5
Mohammad-Ali Shahbazi, Patrick Vingadas Almeida, Alexandra Correia, Barbara Herranz-Blanco, Neha Shrestha, Ermei Mäkilä, Jarno Salonen, Jouni Hirvonen, Hélder A Santos
Bioresponsive cytosolic nanobased multidelivery has been emerging as an enormously challenging novel concept due to the intrinsic protective barriers of the cells and hardly controllable performances of nanomaterials. Here, we present a new paradigm to advance nano-in-nano integration technology amenable to create multifunctional nanovehicles showing considerable promise to overcome restrictions of intracellular delivery, solve impediments of endosomal localization and aid effectual tracking of nanoparticles...
February 1, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28124557/addressing-unmet-clinical-needs-with-uv-bioadhesives
#6
Richard D O'Rorke, Oleksandr Pokholenko, Feng Gao, Ting Cheng, Ankur Shah, Vishal Mogal, Terry W J Steele
The invasive practice of suturing for wound closure has persisted for millennia; with the rate of medical development, it is staggering that there are few viable alternatives to invasive mechanical fasteners. Biocompatible and biodegradable polymers are attractive candidates for versatile bioadhesives and could revolutionize surgical procedures. Bioadhesives can be broadly placed into two groups: activated and instant. Almost all commercially available bioadhesives are instant, which cross-link by mixing two components or on contact with moisture...
February 20, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28123987/bioadhesive-floating-microsponges-of-cinnarizine-as-novel-gastroretentive-delivery-capmul-gmo-bioadhesive-coating-versus-acconon-mc-8-2-ep-nf-with-intrinsic-bioadhesive-property
#7
Smita Raghuvanshi, Kamla Pathak
INTRODUCTION: The study was aimed at the development of low-density gastroretentive bioadhesive microsponges of cinnarizine by two-pronged approach (i) coating with bioadhesive material and (ii) exploration of acconon MC 8-2 EP/NF as bioadhesive raw material for fabrication. MATERIALS AND METHODS: Microsponges were prepared by quasi-emulsion solvent diffusion method using 3(2) factorial design. Capmul GMO was employed for bioadhesive coating. In parallel, potential of acconon for the fabrication of bioadhesive floating microsponges (A8) was assessed...
October 2016: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28122367/enzymology-and-ultrastructure-of-the-in-situ-pellicle-in-caries-active-and-caries-inactive-patients
#8
Jasmin Kirsch, Christian Hannig, Sandra Pötschke, Sabine Basche, William H Bowen, Stefan Rupf, Simone Trautmann, Natalia Umanskaya, Matthias Hannig
AIM: The present study aimed to evaluate the impact of caries activity on the key enzymes and the ultrastructure of the in situ pellicle. METHODS: Pellicle formation was performed on bovine enamel slabs. Intraoral exposure (3, 30, and 120 min) was accomplished by 14 caries-active (DMFS: 22.7 ± 12.1) and 13 caries-inactive (DMFS: 1.5 ± 1.8) individuals. The enzyme activities (lysozyme, peroxidase, α-amylase, glycosyltransferase [GTF]) in the in situ pellicle and resting saliva of all participants were analyzed directly after oral exposure...
January 26, 2017: Caries Research
https://www.readbyqxmd.com/read/28122295/bioadhesive-micelles-of-d-%C3%AE-tocopherol-polyethylene-glycol-succinate-1000-synergism-of-chitosan-and-transferrin-in-targeted-drug-delivery
#9
Poornima Agrawal, Sonali, Rahul Pratap Singh, Gunjan Sharma, Abhishesh K Mehata, Sanjay Singh, Chellapa V Rajesh, Bajarangprasad L Pandey, Biplob Koch, Madaswamy S Muthu
The aim of this work was to prepare targeted bioadhesive d-α- tocopheryl glycol succinate 1000 (TPGS) micelles containing docetaxel (DTX) for brain targeted cancer therapy. Considering the unique bioadhesive feature of chitosan, herein, we have developed a synergistic transferrin receptor targeted bioadhesive micelles using TPGS conjugated chitosan (TPGS-chitosan), which target the overexpressed transferrin receptors of glioma cells for brain cancer therapy. The micelles were prepared by the solvent casting method and characterized for their particle size, polydispersity, zeta-potential, surface morphology, drug encapsulation efficiency, and in-vitro release...
January 15, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28116754/randomised-clinical-trial-mucosal-protection-combined-with-acid-suppression-in-the-treatment-of-non-erosive-reflux-disease-efficacy-of-esoxx-a-hyaluronic-acid-chondroitin-sulphate-based-bioadhesive-formulation
#10
V Savarino, F Pace, C Scarpignato
BACKGROUND: Several studies have shown that patients with non-erosive reflux disease (NERD) are less responsive to proton pump inhibitors (PPIs) than those with erosive disease as they belong to different subgroups, in whom factors other than acid can trigger symptoms. AIM: To evaluate whether combined therapy (mucosal protection plus acid suppression) would improve symptom relief compared to PPI treatment alone. METHODS: In a multicenter, randomised, double-blind trial, 154 patients with NERD were randomised to receive Esoxx (Alfa Wassermann, Bologna, Italy), a hyaluronic acid-chondroitin sulphate based bioadhesive formulation, or placebo, in addition to acid suppression with standard dose PPIs for 2 weeks...
January 24, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28116599/nano-reservoir-bioadhesive-tablets-enhance-protein-drug-permeability-across-the-small-intestine
#11
Lifang Yin, Yong Wang, Cuifeng Wang, Min Feng
Most therapeutic proteins are classified as class III drugs according to the Biopharmaceutical Classification System means that the low permeability across the intestinal epithelium is the rate-limited step for their oral absorption. Cationic chitosan nanoparticles have been found to open the tight junctions between epithelial cells. On the other hand, bioadhesive delivery devices could prolong the gastrointestinal residence time. In the present study, we developed a novel nano-reservoir bioadhesive tablets that combining the advantages of cationic nanoparticles and bioadhesive delivery devices anticipated achieving effective transport of sufficient protein drugs across the intestinal epithelium...
January 23, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28110072/structuring-of-composite-hydrogel-bioadhesives-and-its-effect-on-properties-and-bonding-mechanism
#12
Oded Pinkas, Daniella Goder, Roni Noyvirt, Sivan Peleg, Maayan Kahlon, Meital Zilberman
: Bioadhesives are polymeric hydrogels that can adhere to a tissue after crosslinking and are an essential element in nearly all surgeries worldwide. Several bioadhesives are commercially available. However, none of them are ideal. The main limitation of current tissue adhesives is the tradeoff between biocompatibility and mechanical strength, especially in wet hemorrhagic environments. Our novel bioadhesives are based on the natural polymers gelatin (coldwater fish) and alginate, crosslinked by carbodiimide (EDC)...
January 18, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28103774/formulation-development-and-evaluation-of-lyophilized-nasal-inserts-for-migraine-treatment
#13
Atishkumar Mundada, Harshada Sarode
BACKGROUND: Nasal inserts are novel, solid, bioadhesive dosage forms administered via nasal route for prolonged systemic drug delivery. The principle of the dosage form is that, after administration nasal inserts imbibe nasal fluid from the mucosa and form a gel in the nasal cavity in order to avoid foreign body sensation. The objective of this investigation was the development of chitosan/xanthan gum based bioadhesive nasal inserts of antimigraine drug. METHODS: Lyophilization is more usual technique for the preparation of nasal inserts and it is one of the applied methods for drying of solids either in the form of aqueous solution or rarely in the form of aqueous suspension by using freeze dryers...
January 18, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/28103046/food-protein-based-core-shell-nanocarriers-for-oral-drug-delivery-effect-of-shell-composition-on-in-vitro-and-in-vivo-functional-performance-of-zein-nanocarriers
#14
Mohammed S Alqahtani, M Saiful Islam, Satheesh Podaralla, Radhey S Kaushik, Joshua Reineke, Tofuko Woyengo, Omathanu Perumal
The study was aimed at systematically investigating the influence of shell composition on the particle size, stability, release, cell uptake, permeability, and in vivo gastrointestinal distribution of food protein based nanocarriers for oral delivery applications. Three different core-shell nanocarriers were prepared using food-grade biopolymers including zein-casein (ZC) nanoparticles, zein-lactoferrin (ZLF), nanoparticles and zein-PEG (ZPEG) micelles. Nile red was used as a model hydrophobic dye for in vitro studies...
February 7, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28097478/study-of-the-influence-of-formulation-variables-in-bioadhesive-emulgels-using-response-surface-methodology
#15
Ana Ochoa-Andrade, M Emma Parente, Álvaro Jimenez-Kairuz, Lucía Boinbaser, Annibal Torregrosa
The aim of the present work was to study the main formulation variables that influence attributes of bioadhesive emulgels based on a combination of polymers, using response surface methodology (RSM). Bioadhesive products continue to gain attention in topical cutaneous administration as they allow long residence times on the application site, which is important when a long dermal action and a reduced product administration frequency are desired. A Box-Behnken design of experiments (DoE) was introduced to study the effect of formulation variables on quality attributes of the emulgels...
January 17, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28063967/an-innovative-polysaccharide-nanobased-nail-formulation-for-improvement-of-onychomycosis-treatment
#16
Fernanda C Flores, Roberta S Rosso, Letícia Cruz, Ruy C R Beck, Cristiane B Silva
Tioconazole-loaded nanocapsule suspensions and its coating with a cationic polymer were developed for nail drug delivery. The colloidal systems presented a nanometric size around 155nm for uncoated nanoparticles and 162nm for those with the cationic coating, with negative and positive zeta potential values, respectively. Both nanosuspensions showed drug content close to theoretical values (1mgmL(-1)), association efficiency close to 100% (HPLC) and were able to control tioconazol release. The developed formulations showed in vitro antifungal activity (agar diffusion method) against C...
January 5, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28053528/bottom-up-fabrication-of-zwitterionic-polymer-brushes-on-intraocular-lens-for-improved-biocompatibility
#17
Yuemei Han, Xu Xu, Junmei Tang, Chenghui Shen, Quankui Lin, Hao Chen
Intraocular lens (IOL) is an efficient implantable device commonly used for treating cataracts. However, bioadhesion of bacteria or residual lens epithelial cells on the IOL surface after surgery causes postoperative complications, such as endophthalmitis or posterior capsular opacification, and leads to loss of sight again. In the present study, zwitterionic polymer brushes were fabricated on the IOL surface via bottom-up grafting procedure. The attenuated total reflection-Fourier transform infrared and contact angle measurements indicated successful surface modification, as well as excellent hydrophilicity...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28024192/next-generation-ultrasound-platforms-for-theranostics
#18
Letizia Oddo, Barbara Cerroni, Fabio Domenici, Angelico Bedini, Federico Bordi, Ester Chiessi, Stefan Gerbes, Gaio Paradossi
Microbubbles are a well-established contrast agent which improves diagnostic ultrasound imaging. During the last decade research has focused on expanding their use to include molecular imaging, targeted therapy and imaging modalities other than ultrasound. However, bioadhesion of targeted microbubbles under physiological flow conditions is still difficult to achieve, the main challenge being connected to the poor stability of lipid microbubbles in the body's circulation system. In this article, we investigate the use of polymeric microbubbles based on a poly (vinyl alcohol) shell as an alternative to lipid microbubbles...
December 18, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28005068/immuno-engineered-organoids-for-regulating-the-kinetics-of-b-cell-development-and-antibody-production
#19
Alberto Purwada, Ankur Singh
Induction of B-cell immunity against infection depends on the initiation of the germinal center (GC) reaction in secondary lymphoid organs. Ex vivo recapitulation of the GC reaction in 2D cultures results in transient cell growth, with poor yield and short-term survival. Furthermore, no reported 2D ex vivo system can modulate the kinetics of a GC-like phenotype or the rate of antibody class switching. This protocol describes a methodology for developing immune organoids that partially mimic the B-cell zone of a lymphoid tissue, for efficient and rapid generation of B cells with a GC-like phenotype from naive murine B cells...
January 2017: Nature Protocols
https://www.readbyqxmd.com/read/27992845/pnipam-grafted-surfaces-through-atrp-and-raft-polymerization-chemistry-and-bioadhesion
#20
REVIEW
G Conzatti, S Cavalie, C Combes, J Torrisani, N Carrere, A Tourrette
Biomaterials surface design is critical for the control of materials and biological system interactions. Being regulated by a layer of molecular dimensions, bioadhesion could be effectively tailored by polymer surface grafting. Basically, this surface modification can be controlled by radical polymerization, which is a useful tool for this purpose. The aim of this review is to provide a comprehensive overview of the role of surface characteristics on bioadhesion properties. We place a particular focus on biomaterials functionalized with a brush surface, on presentation of grafting techniques for "grafting to" and "grafting from" strategies and on brush characterization methods...
December 7, 2016: Colloids and Surfaces. B, Biointerfaces
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