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https://www.readbyqxmd.com/read/28432016/inkjet-printing-of-antiviral-pcl-nanoparticles-and-anticancer-cyclodextrin-inclusion-complexes-on-bioadhesive-film-for-cervical-administration
#1
Cem Varan, Henrika Wickström, Niklas Sandler, Yeşim Aktaş, Erem Bilensoy
Personalized medicine is an important treatment approach for diseases like cancer with high intrasubject variability. In this framework, printing is one of the most promising methods since it permits dose and geometry adjustment of the final product. With this study, a combination product consisting of anticancer (paclitaxel) and antiviral (cidofovir) drugs was manufactured by inkjet printing onto adhesive film for local treatment of cervical cancers as a result of HPV infection. Furthermore, solubility problem of paclitaxel was overcome by maintaining this poorly soluble drug in a cyclodextrin inclusion complex and release of cidofovir was controlled by encapsulation in polycaprolactone nanoparticles...
April 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28422529/implant-compositions-for-the-unidirectional-delivery-of-drugs-to-the-brain
#2
Michael McGinity, John Floyd, James McGinity, Feng Zhang
The overall objective of this study was to design and characterize the properties of a bioadhesive trilayer sustained-release implant device for the unidirectional local delivery of anticancer compounds to the brain following the removal of glioblastoma multiforme tumors. Using acetaminophen as a model drug compound, we compressed trilayer wafers that contained (a) a bioadhesive layer, (b) a drug layer that contained a lipid and a pore-forming hydrophilic polymer, and (c) a third layer comprising a lipid substance...
April 19, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28419912/the-mucosal-pellicle-an-underestimated-factor-in-oral-physiology
#3
REVIEW
Christian Hannig, Matthias Hannig, Anna Kensche, Guy Carpenter
Bioadhesion and bio-adsorption of proteins, glycoproteins and other biomolecules are ubiquitous phenomena in the oral cavity. While the protective role of the adsorbed salivary biomolecules on teeth (the acquired enamel pellicle) is well established, it has yet to be defined whether comparable processes occur on the desquamating oral soft tissues. The general term for these layers is pellicle, but due to the different characteristics of the coated surfaces the enamel pellicle and mucosal pellicle are their own entities...
April 8, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28385037/new-for-old-coagulum-lithotomy-versus-a-novel-bioadhesive-for-complete-removal-of-stone-fragments-in-a-comparative-study-in-an-ex-vivo-porcine-model
#4
Dominik Stefan Schoeb, Martin Schoenthaler, Daniel Schlager, Ralf Petzold, Katharina Richter, Ingo Grunwald, Ulrich Wetterauer, Arkadiusz Miernik, Simon Hein
OBJECTIVES: To evaluate a recently reported new bioadhesive system for the retrieval of small residual fragments after intracorporeal lithotripsy, we systematically compared this system with coagulum lithotomy in retrograde intrarenal surgery. MATERIALS AND METHODS: We extracted 30 human stone fragments (≤1 mm) in an ex vivo porcine kidney model using a flexible ureteroscope for three groups: 1) the novel bioadhesive, 2) autologous blood as a natural adhesive, and 3) (control group) a conventional retrieval basket...
April 6, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28367220/lectins-interconnecting-proteins-with-biotechnological-pharmacological-and-therapeutic-applications
#5
REVIEW
Luana Cassandra Breitenbach Barroso Coelho, Priscila Marcelino Dos Santos Silva, Vera Lúcia de Menezes Lima, Emmanuel Viana Pontual, Patrícia Maria Guedes Paiva, Thiago Henrique Napoleão, Maria Tereza Dos Santos Correia
Lectins are proteins extensively used in biomedical applications with property to recognize carbohydrates through carbohydrate-binding sites, which identify glycans attached to cell surfaces, glycoconjugates, or free sugars, detecting abnormal cells and biomarkers related to diseases. These lectin abilities promoted interesting results in experimental treatments of immunological diseases, wounds, and cancer. Lectins obtained from virus, microorganisms, algae, animals, and plants were reported as modulators and tool markers in vivo and in vitro; these molecules also play a role in the induction of mitosis and immune responses, contributing for resolution of infections and inflammations...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28364672/efficacy-of-a-mouthrinse-based-on-hydroxyapatite-to-reduce-initial-bacterial-colonisation-in-situ
#6
A Kensche, C Holder, S Basche, N Tahan, C Hannig, M Hannig
OBJECTIVE: The present in situ - investigation aimed to specify the impact of pure hydroxyapatite microclusters on initial bioadhesion and bacterial colonization at the tooth surface. DESIGN: Pellicle formation was carried out in situ on bovine enamel slabs (9 subjects). After 1min of pellicle formation rinses with 8ml of hydroxyapatite (HA) microclusters (5%) in bidestilled water or chlorhexidine 0.2% were performed. As negative control no rinse was adopted. In situ biofilm formation was promoted by the intraoral slab exposure for 8h overnight...
March 23, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28298824/comparative-evaluation-of-healing-after-periodontal-flap-surgery-using-isoamyl-2-cyanoacrylate-bioadhesive-material-and-silk-sutures-a-split-mouth-clinical-study
#7
Jyotsana Veneet Khurana, Amita Milind Mali, Rohini Salil Mali, Amit Ulhas Chaudhari
BACKGROUND: Many factors contribute to uneventful and healthy postoperative healing. Hence, closure of periodontal flap postsurgery for the attainment of primary union between flap margins is of utmost importance. Isoamyl 2-cyanoacrylate is a tissue adhesive, which can be used for the closure of elevated flaps to overcome the problems associated with conventional suture material like silk. AIM: This study aims to compare healing after periodontal flap surgery using isoamyl 2-cyanoacrylate (bioadhesive material) and silk sutures...
July 2016: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/28296024/a-moldable-nanocomposite-hydrogel-composed-of-a-mussel-inspired-polymer-and-a-nanosilicate-as-a-fit-to-shape-tissue-sealant
#8
Yuan Liu, Hao Meng, Zichen Qian, Ni Fan, Wonyoung Choi, Feng Zhao, Bruce P Lee
The engineering of bioadhesives to bind and conform to the complex contour of tissue surfaces remains a challenge. We have developed a novel moldable nanocomposite hydrogel by combining dopamine-modified poly(ethylene glycol) and the nanosilicate Laponite, without the use of cytotoxic oxidants. The hydrogel transitioned from a reversibly cross-linked network formed by dopamine-Laponite interfacial interactions to a covalently cross-linked network through the slow autoxidation and cross-linking of catechol moieties...
April 3, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28271373/optimization-and-evaluation-of-gastroretentive-ranitidine-hcl-microspheres-by-using-factorial-design-with-improved-bioavailability-and-mucosal-integrity-in-ulcer-model
#9
Abeer Khattab, Nashwah Zaki
The purpose of our investigation was to develop and optimize the drug entrapment efficiency and bioadhesion properties of mucoadhesive chitosan microspheres containing ranitidine HCl prepared by an ionotropic gelation method as a gastroretentive delivery system; thus, we improved their protective and therapeutic gastric effects in an ulcer model. A 3 × 2(2) full factorial design was adopted to study the effect of three different factors, i.e., the type of polymer at three levels (chitosan, chitosan/hydroxypropylmethylcellulose, and chitosan/methylcellulose), the type of solvent at two levels (acetic acid and lactic acid), and the type of chitosan at two levels (low molecular weight (LMW) and high molecular weight (HMW))...
March 7, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28263845/new-polyurethane-nail-lacquers-for-the-delivery-of-terbinafine-formulation-and-antifungal-activity-evaluation
#10
Barbara S Gregorí Valdes, Ana Paula Serro, Paulo M Gordo, Alexandra Silva, Lídia Gonçalves, Ana Salgado, Joana Marto, Diogo Baltazar, Rui Galhano Dos Santos, João Moura Bordado, Helena Margarida Ribeiro
Onychomycosis is a fungal nail infection. The development of new topical antifungal agents for the treatment of onychomycosis has focused on formulation enhancements that optimize the pharmacological characteristics required for its effective treatment. Polyurethanes (PUs) have never been used in therapeutic nail lacquers. The aim of this work has been the development of new PU based nail lacquers with antifungal activity containing 1.0% (w/w) of terbinafine hydrochloride. The biocompatibility, wettability and the prediction of the free volume in the polymeric matrix were assessed using a human keratinocytes cell line, contact angle and Positron Annihilation Lifetime Spectroscopy (PALS) determinations, respectively...
March 2, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28257881/dual-mechanism-gastroretentive-drug-delivery-system-loaded-with-an-amorphous-solid-dispersion-prepared-by-hot-melt-extrusion
#11
Anh Q Vo, Xin Feng, Manjeet Pimparade, Xinyou Ye, Dong Wuk Kim, Scott T Martin, Michael A Repka
In the present study, we aimed to prepare a gastroretentive drug delivery system that would be both highly resistant to gastric emptying via multiple mechanisms and would also potentially induce in situ supersaturation. The bioadhesive floating pellets, loaded with an amorphous solid dispersion, were prepared in a single step of hot-melt extrusion technology. Hydroxypropyl cellulose (Klucel™ MF) and hypromellose (Benecel™ K15M) were used as matrix-forming polymers, and felodipine was used as the model drug...
February 28, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28256600/chitosan-coated-mesoporous-mil-100-fe-nanoparticles-as-improved-bio-compatible-oral-nanocarriers
#12
T Hidalgo, M Giménez-Marqués, E Bellido, J Avila, M C Asensio, F Salles, M V Lozano, M Guillevic, R Simón-Vázquez, A González-Fernández, C Serre, M J Alonso, P Horcajada
Nanometric biocompatible Metal-Organic Frameworks (nanoMOFs) are promising candidates for drug delivery. Up to now, most studies have targeted the intravenous route, related to pain and severe complications; whereas nanoMOFs for oral administration, a commonly used non-invasive and simpler route, remains however unexplored. We propose here the biofriendly preparation of a suitable oral nanocarrier based on the benchmarked biocompatible mesoporous iron(III) trimesate nanoparticles coated with the bioadhesive polysaccharide chitosan (CS)...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28251063/evaluation-of-a-chitosan-polyethylene-glycol-paste-as-a-local-antibiotic-delivery-device
#13
Cheyenne S Rhodes, Christopher M Alexander, Joel M Berretta, Harry S Courtney, Karen E Beenken, Mark S Smeltzer, Joel D Bumgardner, Warren O Haggard, J Amber Jennings
AIM: To investigate the efficacy of a chitosan/polyethylene glycol blended paste as a local antibiotic delivery device, particularly in musculoskeletal wounds. METHODS: Acidic (A) chitosan sponges and neutralized (N) chitosan/polyethylene glycol (PEG) blended sponges were combined in ratios of 3A:2N, 1A:1N, and 2A:3N; then hydrated with phosphate buffered saline to form a chitosan/PEG paste (CPP). Both in vitro and in vivo studies were conducted to determine the potential CPP has as a local antibiotic delivery device...
February 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28247291/bioadhesive-drug-delivery-system-for-enhancing-the-permeability-of-a-bcs-class-iii-drug-via-hot-melt-extrusion-technology
#14
Nicole S Mendonsa, Priyanka Thipsay, Dong Wuk Kim, Scott T Martin, Michael A Repka
As the buccal route of administration has the ability to avoid the GI tract and first-pass effect by directing the absorption toward the cheek area, the bioavailability of BCS class III drugs can be increased through this route. Only a handful of studies have been conducted using oleic acid as a permeation enhancer in any transbuccal drug delivery system. Therefore, the objectives of this novel study were to develop a buccal tablet using two concentrations of oleic acid for a model BCS class III drug via hot-melt extrusion technology and to investigate the effects of oleic acid on the physicochemical properties of the tablet...
February 28, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28244533/biomimetic-polymeric-superhydrophobic-surfaces-and-nanostructures-from-fabrication-to-applications
#15
REVIEW
Gang Wen, ZhiGuang Guo, Weimin Liu
Numerous research studies have contributed to the development of mature superhydrophobic systems. The fabrication and applications of polymeric superhydrophobic surfaces have been discussed and these have attracted tremendous attention over the past few years due to their excellent properties. In general, roughness and chemical composition, the two most crucial factors with respect to surface wetting, provide the basic criteria for yielding polymeric superhydrophobic materials. Furthermore, with their unique properties and flexible configurations, polymers have been one of the most efficient materials for fabricating superhydrophobic materials...
February 28, 2017: Nanoscale
https://www.readbyqxmd.com/read/28230790/influence-of-chitosan-swelling-behaviour-on-controlled-release-of-tenofovir-from-mucoadhesive-vaginal-systems-for-prevention-of-sexual-transmission-of-hiv
#16
Fernando Notario-Pérez, Araceli Martín-Illana, Raúl Cazorla-Luna, Roberto Ruiz-Caro, Luis-Miguel Bedoya, Aitana Tamayo, Juan Rubio, María-Dolores Veiga
The main challenges facing efforts to prevent the transmission of human immunodeficiency virus (HIV) are the lack of access to sexual education services and sexual violence against young women and girls. Vaginal formulations for the prevention of sexually transmitted infections are currently gaining importance in drug development. Vaginal mucoadhesive tablets can be developed by including natural polymers that have good binding capacity with mucosal tissues, such as chitosan or guar gum, semisynthetic polymers such as hydroxypropylmethyl cellulose, or synthetic polymers such as Eudragit(®) RS...
February 21, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28223860/polymeric-films-as-a-promising-carrier-for-bioadhesive-drug-delivery-development-characterization-and-optimization
#17
Pallavi Bassi, Gurpreet Kaur
Bioadhesive films using tamarind seed polysaccharide were prepared for the treatment of candida vaginitis using nystatin as the model drug. Films were prepared by solvent casting method. A 3(2) factorial design was employed to study the effect of independent variables (polymer and plasticizer concentration) on a range of dependent variables namely mechanical, swelling, interfacial, and bioadhesive properties through response surface methodological approach, using Design Expert® software. Formulation composition that provided the most desired and optimized results was selected using desirability approach...
January 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28207269/biocompatible-injectable-hydrogel-with-potent-wound-healing-and-antibacterial-properties
#18
Jiaul Hoque, Relekar G Prakash, Krishnamoorthy Paramanandham, Bibek R Shome, Jayanta Haldar
Two component injectable hydrogels that cross-link in situ have been used as noninvasive wound-filling devices, i.e., sealants. These materials carry a variety of functions at the wound sites, such as sealing leaks, ceasing unwanted bleeding, binding tissues together, and assisting in wound healing processes. However, commonly used sealants typically lack antibacterial properties. Since bacterial infection at the wound site is very common, bioadhesive materials with intrinsic antibacterial properties are urgently required...
April 3, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28186213/multifunctional-biocompatible-and-ph-responsive-carbon-nanotube-and-graphene-oxide-tectomer-hybrid-composites-and-coatings
#19
Rosa Garriga, Izabela Jurewicz, Shayan Seyedin, Niki Bardi, Stella Totti, Brigitta Matta-Domjan, Eirini G Velliou, Mohammed A Alkhorayef, Vicente L Cebolla, Joselito M Razal, Alan B Dalton, Edgar Muñoz
Here we present a route for non-covalent functionalization of carboxylated multi-walled carbon nanotubes and graphene oxide with novel two-dimensional peptide assemblies. We show that self-assembled amino-terminated biantennary and tetraantennary oligoglycine peptides (referred to as tectomers) effectively coat carboxylated multi-walled carbon nanotubes and also strongly interact with graphene oxide due to electrostatic interactions and hydrogen bonding as the driving force, respectively. The resulting hybrids can be made into free-standing conducting composites or applied in the form of thin, pH-switchable bioadhesive coatings onto graphene oxide fibers...
February 10, 2017: Nanoscale
https://www.readbyqxmd.com/read/28183625/the-design-of-superhydrophobic-stainless-steel-surfaces-by-controlling-nanostructures-a-key-parameter-to-reduce-the-implantation-of-pathogenic-bacteria
#20
Jérôme Bruzaud, Jeanne Tarrade, Elena Celia, Thierry Darmanin, Elisabeth Taffin de Givenchy, Frédéric Guittard, Jean-Marie Herry, Morgan Guilbaud, Marie-Noëlle Bellon-Fontaine
Reducing bacterial adhesion on substrates is fundamental for various industries. In this work, new superhydrophobic surfaces are created by electrodeposition of hydrophobic polymers (PEDOT-F4 or PEDOT-H8) on stainless steel with controlled topographical features, especially at a nano-scale. Results show that anti-bioadhesive and anti-biofilm properties require the control of the surface topographical features, and should be associated with a low adhesion of water onto the surface (Cassie-Baxter state) with limited crevice features at the scale of bacterial cells (nano-scale structures)...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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