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https://www.readbyqxmd.com/read/28822703/turning-the-screw-even-further-to-increase-microparticle-retention-and-ocular-bioavailability-of-associated-drugs-the-bioadhesion-goal
#1
J Rodríguez Villanueva, L Rodríguez Villanueva
Ocular drug delivery is one of the most fascinating and challenging tasks facing pharmaceutical researchers. Improving drug ocular residence time and/or penetration is complex. Microparticles (MP) provide interesting opportunities to increase ocular bioavailability of drugs and patient compliance brought about by decreased frequency of dosing. However, sustained-release microsphere formulation would fail to accomplish the task of long-lasting drug release unless microspheres remained for a prolonged period at the site of action...
August 16, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28809108/dual-regulations-of-thermo-sensitive-heparin-poloxamer-hydrogel-using-%C3%AE%C2%B5-polylysine-bioadhesivity-and-controlled-kgf-release-for-enhancing-wound-healing-of-endometrial-injury
#2
He-Lin Xu, Jie Xu, Bi-Xin Shen, Si-Si Zhang, Bing-Hui Jin, Qun-Yan Zhu, De-Li ZhuGe, Xue-Qing Wu, Jian Xiao, Yingzheng Zhao
ydrogel was not only used as an effective support matrix to prevent intrauterine adhesion (IUA) after endometrial injury but also served as scaffold to sustain release of some therapeutics, especially growth factor. However, because of the rapid turnover of the endometrial mucus, the poor retention and bad absorption of therapeutic agents in damaged endometrial cavity were two important factors hindering their pharmacologic effect. Herein, a mucoadhesive hydrogel was described by using heparin-modified poloxamer (HP) as the matrix material and ε-polylysine (EPL) as functional excipient...
August 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28804018/anti-biofilm-activity-of-a22-s-3-4-dichlorobenzyl-isothiourea-hydrochloride-against-pseudomonas-aeruginosa-influence-on-biofilm-formation-motility-and-bioadhesion
#3
Pauline Cordenonsi Bonez, Grazielle Guidolin Rossi, Jardel Rodrigo Bandeira, Andiara Prates Ramos, Caren Rigon Mizdal, Vanessa Albertina Agertt, Eloísa Salete Segatto Dalla Nora, Márcia Ebling de Souza, Camilla Fillippi Dos Santos Alves, Fallon Siqueira Dos Santos, André Gündel, Rodrigo de Almeida Vaucher, Roberto Christ Vianna Santos, Marli Matiko Anraku de Campos
Bacterial biofilms are involved in various medical infections and for this reason it is of great importance understanding adhesion mechanisms of involved microorganisms is essential to develop new strategies of prevention and control. Different approaches have been used for preventing biofilm related infections in health care settings, such as use of surface coatings agents in medical implants. In this context, is necessary to explore new compounds with anti-biofilm activity. Thus, this study evaluated for the first time the action of A22 against biofilms of Pseudomonas aeruginosa PAO1 strain and multi-resistant clinical isolates on biotic and abiotic surfaces...
August 10, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28750895/genotoxic-evaluation-of-poly-anhydride-nanoparticles-in-the-gastrointestinal-tract-of-mice
#4
T Iglesias, J M Irache, M Butinar, B Turk, A López de Cerain, A Azqueta
Gantrez(®) AN 119-based NPs have been developed as oral drug carriers due to their strong bioadhesive interaction with components of the gastrointestinal mucosa and to their adaptable surface. The use of mannosamine to coat Gantrez(®) AN 119-based NPs results in a high mucus-permeable carrier, able to reach the gastrointestinal epithelium. Although their efficacy to transport a therapeutic agent has been demonstrated, their safety has not yet been thoroughly studied. They have proved to be non-cytotoxic, non-genotoxic and non-mutagenic in vitro; however, the in vivo toxicity profile has not yet been determined...
July 24, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28732712/structure-performance-relationships-of-temperature-responsive-plga-peg-plga-gels-for-sustained-release-of-bone-morphogenetic-protein-2
#5
Ana Santoveña, Cecilia Monzón, Carmen Alvarez-Lorenzo, Carlos Del Rosario, Araceli Delgado, Carmen Evora, Angel Concheiro, Matias Llabrés, José B Fariña
PLGA (poly(lactic-co-glycolic) acid)-PEG (polyethylene glycol)-PLGA synthesis conditions have an impact on the physicochemical features of the copolymer and its usefulness as biomaterial. This study reports on an analysis of the composition and structural properties of PLGA-PEG-PLGA copolymers applying a variety of analytical techniques. Viscoelastic properties and particularly the temperature-responsive behavior of PLGA-PEG-PLGA showed a marked dependence on copolymer structural features. Physicochemical and biological properties, such as bioadhesion, biocompatibility and cell viability, of the raw copolymers and their gels were also evaluated...
July 19, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28707165/design-preparation-and-evaluation-of-hpmc-based-paa-or-sa-freeze-dried-scaffolds-for-vaginal-delivery-of-fluconazole
#6
Carmen Anatolia Gafitanu, Daniela Filip, Corina Cernatescu, Daniela Rusu, Cristina Gabriela Tuchilus, Doina Macocinschi, Mirela-Fernanda Zaltariov
PURPOSE: Aim of this work was preparation of bioadhesive gel formulations based on Hydroxypropyl methylcellulose (HPMC), Poly(acrylic acid) (PAA) or Sodium alginate (SA) loaded with anise/fluconazole β-cyclodextrin inclusion complexes in 1:2 and 1:3 ratios intended for vaginal applications. METHODS: Freeze-drying method was effectively utilized and superporous morphology was obtained. The superporous morphology of the lyophilized gels, dynamic water vapor sorption measurements, drug release kinetics studies and their antimicrobial activities are presented...
July 13, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28705624/evaluation-of-three-layered-doxycycline-collagen-loaded-nanofiber-wound-dressing
#7
Serdar Tort, Füsun Acartürk, Arzu Beşikci
Nanofiber wound dressings have great potential for both acute and chronic wound healing. The aim of this study is to develop a wound dressing by the electrospinning method and to determine its in vitro characteristics. The viscosity and the surface tension values of the polymer solutions used in the electrospinning were measured and their suitability for electrospinning was evaluated. Nanofiber wound dressing consists of three layers. The first and the second layers are sodium alginate and chitosan nanofibers, respectively...
July 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28703765/anti-biofilm-effect-of-biodegradable-coatings-based-on-hemibastadin-derivative-in-marine-environment
#8
Tiffany Le Norcy, Hendrik Niemann, Peter Proksch, Isabelle Linossier, Karine Vallée-Réhel, Claire Hellio, Fabienne Faÿ
Dibromohemibastadin-1 (DBHB) is an already known potent inhibitor of blue mussel phenoloxidase (which is a key enzyme involved in bioadhesion). Within this study, the potentiality of DBHB against microfouling has been investigated. The activity of DBHB was evaluated on key strains of bacteria and microalgae involved in marine biofilm formation and bioassays assessing impact on growth, adhesion and biofilm formation were used. To assess the efficiency of DBHB when included in a matrix, DBHB varnish was prepared and the anti-microfouling activity of coatings was assessed...
July 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28678473/bioadhesive-nanoaggregates-based-on-polyaspartamide-g-c18-dopa-for-wound-healing
#9
Sooyoun Lim, Minh Phuong Nguyen, Youngjin Choi, Jaeyun Kim, Dukjoon Kim
Biocompatible adhesive nanoaggregates were synthesized based on polyaspartamide copolymers grafted with octadecylamine (C18) and 3,4-dihydroxyphenylalanine (DOPA), and their adhesive properties were investigated with regard to wound healing. The chemical structure and morphology of the synthesized polyaspartamide-g-C18/DOPA nanoaggregates were analyzed using (1)H-nuclear magnetic resonance spectroscopy ((1)H NMR), dynamic light scattering (DLS), and transmission electron microscope (TEM). The in vitro adhesive energy was up to 31...
July 5, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28672810/development-and-characterization-of-an-amorphous-solid-dispersion-of-furosemide-in-the-form-of-a-sublingual-bioadhesive-film-to-enhance-bioavailability
#10
Viviana De Caro, Alessia Ajovalasit, Flavia Maria Sutera, Denise Murgia, Maria Antonietta Sabatino, Clelia Dispenza
Administered by an oral route, Furosemide (FUR), a diuretic used in several edematous states and hypertension, presents bioavailability problems, reported as a consequence of an erratic gastrointestinal absorption due to various existing polymorphic forms and low and pH-dependent solubility. A mucoadhesive sublingual fast-dissolving FUR based film has been developed and evaluated in order to optimize the bioavailability of FUR by increasing solubility and guaranteeing a good dissolution reproducibility. The Differential Scanning Calorimetry (DSC) analyses confirmed that the film prepared using the solvent casting method entrapped FUR in the amorphous state...
June 24, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28669792/preparation-and-characterization-of-bioadhesive-system-containing-hypericin-for-local-photodynamic-therapy
#11
Fernanda Belincanta Borghi-Pangoni, Mariana Volpato Junqueira, Sabrina Barbosa de Souza Ferreira, Larissa Lachi Silva, Bruno Ribeiro Rabello, Lidiane Vizioli de Castro, Mauro Luciano Baesso, Andréa Diniz, Wilker Caetano, Marcos Luciano Bruschi
Hypericin (Hyp) is a natural photoactive pigment utilized in the treatment of different types of cancer and antimicrobial inactivation using photodynamic therapy (PDT). Hyp is poorly soluble in water conducing to problems of administration, getting closeness contact with the site, and availability. Therefore, this study aimed to develop bioadhesive thermoresponsive system containing Hyp for local PDT. I this sense, carbomer 934P, poloxamer 407, and Hyp were used to prepare the thermoresponsive bioadhesive formulations...
June 29, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28656749/bioinspired-synthesis-of-photocatalytic-nanocomposite-membranes-based-on-synergy-of-au-tio2-and-polydopamine-for-degradation-of-tetracycline-under-visible-light
#12
Chen Wang, Yilin Wu, Jian Lu, Juan Zhao, Jiuyun Cui, Xiuling Wu, Yongsheng Yan, Pengwei Huo
A bioinspired photocatalytic nanocomposite membrane was successfully prepared via polydopamine (pDA)-coated poly(vinylidene fluoride) (PVDF) membrane, as a secondary platform for vacuum-filtrated Au-TiO2 nanocomposites, with enhanced photocatalytic activity. The degradation efficiency of Au-TiO2/pDA/PVDF membranes reached 92% when exposed to visible light for 120 min, and the degradation efficiency of Au-TiO2/pDA/PVDF membranes increased by 26% compared to that of Au-TiO2 powder and increased by 51% compared to that of TiO2/pDA/PVDF nanocomposite membranes...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28652172/enhancement-and-inhibition-effects-on-the-corneal-permeability-of-timolol-maleate-polymers-cyclodextrins-and-chelating-agents
#13
Isabel Rodríguez, José Antonio Vázquez, Lorenzo Pastrana, Vitaliy V Khutoryanskiy
This study investigates how both bioadhesive polymers (chitosan, hyaluronic acid and alginate) and permeability enhancers (ethylene glycol- bis(2-aminoethylether)- N, N, N', N'- tetraacetic acid (EGTA) and hydroxypropyl-ß-cyclodextrin) influence the permeability of the anti-glaucoma drug timolol maleate through ex vivo bovine corneas. Our results showed that only the permeability enhancers alone were able to increase drug permeability, whereas the polymers significantly reduced drug permeation, and however, they increased the pre-corneal residence of timolol...
June 23, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28650092/photoactivatable-mussel-based-underwater-adhesive-proteins-by-an-expanded-genetic-code
#14
Mathias Hauf, Florian Richter, Tobias Schneider, Thomas Faidt, Berta M Martins, Tobias Baumann, Patrick Durkin, Holger Dobbek, Karin Jacobs, Andreas Möglich, Nediljko Budisa
Marine mussels exhibit potent underwater adhesion abilities under hostile conditions employing 3,4-dihydroxy-phenylalanine (Dopa)-rich mussel-adhesive proteins (MAPs). However, their recombinant production is a major biotechnological challenge. Here, we have developed a novel strategy based on genetic code expansion by engineering efficient aminoacyl-tRNA synthetases (aaRSs) for the photocaged non-canonical amino acid (ncAA) ortho-nitrobenzyl Dopa (ONB-Dopa). The engineered ONB-DopaRS enables in vivo production of MAP type 5 site-specifically equipped with multiple instances of ONB-Dopa yielding spatiotemporally controlled underwater adhesives...
June 26, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28638787/bioadhesive-bacterial-microswimmers-for-targeted-drug-delivery-in-the-urinary-and-gastrointestinal-tracts
#15
Babak Mostaghaci, Oncay Yasa, Jiang Zhuang, Metin Sitti
Bacteria-driven biohybrid microswimmers (bacteriabots), which integrate motile bacterial cells and functional synthetic cargo parts (e.g., microparticles encapsulating drug), are recently studied for targeted drug delivery. However, adhesion of such bacteriabots to the tissues on the site of a disease (which can increase the drug delivery efficiency) is not studied yet. Here, this paper proposes an approach to attach bacteriabots to certain types of epithelial cells (expressing mannose on the membrane), based on the affinity between lectin molecules on the tip of bacterial type I pili and mannose molecules on the epithelial cells...
June 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28615944/the-interactions-of-single-wall-carbon-nanohorns-with-polar-epithelium
#16
Yujie Shi, Zujin Shi, Suxin Li, Yuan Zhang, Bing He, Dong Peng, Jie Tian, Ming Zhao, Xueqing Wang, Qiang Zhang
Single-wall carbon nanohorns (SWCNHs), which have multitudes of horn interstices, an extensive surface area, and a spherical aggregate structure, offer many advantages over other carbon nanomaterials being used as a drug nanovector. The previous studies on the interaction between SWCNHs and cells have mostly emphasized on cellular uptake and intracellular trafficking, but seldom on epithelial cells. Polar epithelium as a typical biological barrier constitutes the prime obstacle for the transport of therapeutic agents to target site...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28614950/grafting-of-architecture-controlled-poly-styrene-sodium-sulfonate-onto-titanium-surfaces-using-bio-adhesive-molecules-surface-characterization-and-biological-properties
#17
Hamza Chouirfa, Margaret D M Evans, David G Castner, Penny Bean, Dimitri Mercier, Anouk Galtayries, Céline Falentin-Daudré, Véronique Migonney
This contribution reports on grafting of bioactive polymers such as poly(sodium styrene sulfonate) (polyNaSS) onto titanium (Ti) surfaces. This grafting process uses a modified dopamine as an anchor molecule to link polyNaSS to the Ti surface. The grafting process combines reversible addition-fragmentation chain transfer polymerization, postpolymerization modification, and thiol-ene chemistry. The first step in the process is to synthetize architecture controlled polyNaSS with a thiol end group. The second step is the adhesion of the dopamine acrylamide (DA) anchor onto the Ti surfaces...
June 14, 2017: Biointerphases
https://www.readbyqxmd.com/read/28599154/the-importance-of-the-relationship-between-mechanical-analyses-and-rheometry-of-mucoadhesive-thermoresponsive-polymeric-materials-for-biomedical-applications
#18
Sabrina Barbosa De Souza Ferreira, Jéssica Bassi Da Silva, Mariana Volpato Junqueira, Fernanda Belincanta Borghi-Pangoni, Raquel Guttierres Gomes, Marcos Luciano Bruschi
Pluronic F127(®) was associated with a carbomer homopolymer type B, as a model polymer blend to evidence the information provided by rheological and mechanical analyses on the development of bioadhesive thermoresponsive systems. The mechanical analysis enabled to observe that 20% (w/w) Pluronic F127(®)-polymer blends were harder, more adhesive, more mucoadhesive, more compressive and less soft. In addition, continuous flow rheometry demonstrated that the systems were plastic with rheopexy (15%, w/w, Pluronic F127(®)) or thixotropic (20%, w/w, Pluronic F127(®))...
June 2, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28597123/vaginal-drug-delivery-for-the-localised-treatment-of-cervical-cancer
#19
REVIEW
Ian Major, Christopher McConville
Cervical cancer is usually treated by surgery, with the more advanced cancers requiring adjuvant chemotherapy or radiotherapy. The location of the cervix makes it easily accessible through the vagina for the localised delivery of chemotherapeutic drugs. Localised delivery has the advantage of direct delivery to the site of action resulting in a lower dose having to be required and a reduction in systemic side effects. This approach would be advantageous for fertility sparing surgery, whereby localised delivery could be used to reduce tumour size allowing for a much smaller tumour to be removed, reducing the risk of preterm birth...
June 8, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28579065/engineering-a-sprayable-and-elastic-hydrogel-adhesive-with-antimicrobial-properties-for-wound-healing
#20
Nasim Annabi, Devyesh Rana, Ehsan Shirzaei Sani, Roberto Portillo-Lara, Jessie L Gifford, Mohammad M Fares, Suzanne M Mithieux, Anthony S Weiss
Hydrogel-based bioadhesives have emerged as alternatives for sutureless wound closure, since they can mimic the composition and physicochemical properties of the extracellular matrix. However, they are often associated with poor mechanical properties, low adhesion to native tissues, and lack of antimicrobial properties. Herein, a new sprayable, elastic, and biocompatible composite hydrogel, with broad-spectrum antimicrobial activity, for the treatment of chronic wounds is reported. The composite hydrogels were engineered using two ECM-derived biopolymers, gelatin methacryloyl (GelMA) and methacryloyl-substituted recombinant human tropoelastin (MeTro)...
September 2017: Biomaterials
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