Lamis Yehia, Gilman Plitt, Ann M Tushar, Julia Joo, Carol A Burke, Steven C Campbell, Katherine Heiden, Judy Jin, Carole Macaron, Chad M Michener, Holly J Pederson, Kadakkal Radhakrishnan, Joyce Shin, Joan Tamburro, Sujata Patil, Charis Eng
IMPORTANCE: Identifying hereditary cancer predisposition facilitates high-risk organ-specific cancer surveillance and prevention. In PTEN hamartoma tumor syndrome (PHTS), longitudinal studies remain lacking, and there are insufficient data on cancers in children and young adults, as well as individuals with neurodevelopmental disorders (NDD). OBJECTIVE: To evaluate lifetime cancer risks, including second malignant neoplasms (SMN), among patients with PHTS. DESIGN, SETTING, AND PARTICIPANTS: Prospective longitudinal cohort study (September 1, 2005, through January 6, 2022)...
April 3, 2023: JAMA Network Open