Perversion

BACKGROUND: Online administration of surveys has a number of advantages but can also lead to increased exposure to bad actors (human and non-human bots) who can try to influence the study results or to benefit financially from the survey. We analyze data collected through an online discrete-choice experiment (DCE) survey to evaluate the likelihood that bad actors can affect the quality of the data collected. METHODS: We developed and fielded a survey instrument that included two sets of DCE questions asking respondents to select their preferred treatments for multiple myeloma therapies...

In this paper, the authors explore the depiction of perversion and the associated interplay of life and death drives in Roman Polanski's 1992 film Bitter Moon . To begin with, a theoretical discussion is presented regarding perverse organizations of mastery and sadomasochism. Perversion is viewed as an expression of the death drive under erotic disguise, in which the destructive fingerprint of the death drive is revealed at every stage, having as its ultimate purpose the destruction of the other. Based on these theoretical insights a dialogue is developed with Polanski's film, which brings to life the theory of sadomasochistic relations through the multidimensional aesthetic medium of cinema...

Intense public interest in scientific claims about COVID-19, concerning its origins, modes of spread, evolution, and preventive and therapeutic strategies, has focused attention on the values to which scientists are assumed to be committed and the relationship between science and other public discourses. A much discussed claim, which has stimulated several inquiries and generated far-reaching political and economic consequences, has been that SARS-CoV-2 was deliberately engineered at the Wuhan Institute of Virology and then, either inadvertently or otherwise, released to the public by a laboratory worker...

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BACKGROUND/OBJECTIVES: Cataract surgery with intraocular lens (IOL) implantation is one of the most commonly performed surgeries worldwide. Within the UK, publicly funded cataract surgery is remunerated by two models: (1) "block contract" (BC), which commissions organisations to deliver whole service pathways without considering specific activity items; or (2) "payment by results" (PbR), which pays a tariff price for each procedure. This study aimed to examine the association between remuneration model and the cost and types of IOL used...

Many educators and pedagogues around the world face challenging situations in their everyday work. Being caught off guard when children begin to explore their bodies and show curiosity about body parts and sexual issues is one of the most uncomfortable realities in the work of educating our children and can generate a series of worrying questions, such as, "Is this child* normal? Should I stop him/ her from masturbating? What should I tell him/her?. Although talking to children about body changes and sexual matters may seem strange or embarrassing, providing correct and age-appropriate information is one of the most important things kindergarten employees can do to ensure that children grow up protected, healthy and safe in their bodies...

Current land use systems in the Amazon largely consist of extensive conventional productivist livestock operations that drive deforestation. Silvopastoral systems (SPS) support a transition to low carbon production if they intensify in sympathy with the needs of biophysical and socio-economic contexts. SPS have been promoted for decades as an alternative livestock production system but widespread uptake has yet to be seen. We provide a schema of associating factors for adoption of SPS based on past literature in tropical agriculture and apply this to a bespoke survey of 172 farms in the Caquetá region of the Colombian Amazon...

The words integrity, ethics and governance are used interchangeably in relation to research. This masks important differences that must be understood when trying to address concerns regarding research culture. While progress has been made in identifying negative aspects of research culture (such as inequalities in hiring/promotion, perverse incentives etc.), and practical issues that lead to research waste (outcome reporting bias, reproducibility etc.), the responsibility for addressing these problems can be unclear due to the complexity of the research environment...

Germline genetic testing for inherited cancer risk has shifted to multi-gene panel tests (MGPTs). While MGPTs detect more pathogenic variants, they also detect more variants of uncertain significance (VUSs) that increase the possibility of harms such as unnecessary surgery. Data sharing by laboratories is critical to addressing the VUS problem. However, barriers to sharing and an absence of incentives have limited laboratory contributions to the ClinVar database. Payers can play a crucial role in the expansion of knowledge and effectiveness of genetic testing...

The present paper attempts to define "time" in clinical-psychoanalytic terms. After brief remarks on time, on timelessness, on times, and on Nachträglichkeit, the treatment of a breakdown state is described. The breakdown from the earliest period of the patient's life first manifested itself in an autistoid perversion. It finally occurred in the transference in a presence moment and could become conceivable as a thought for the patient in a turbulent process. Here two time dimensions became apparent: The timeless state of breakdown unfolds in the treatment in such a way that preforms of temporal experiences precede the event of time in presence moment, from which then the times past, future and present can become...

OBJECTIVE: To examine trends in the cost of medicines, consultation fees and clinic visits among the employees covered by the employer health insurance in Malaysia's private primary healthcare system in Malaysia. DESIGNS: Retrospective cross-sectional study. SETTING: PMCare claims database from January 2016 to August 2019. PARTICIPANTS: A total of 83,556 outpatient clinic visits involving 10,150 IIUM employees of the International Islamic University Malaysia (IIUM) to private general practitioners (GPs)...

BACKGROUND: Reducing antibiotic treatment duration is a key component of hospital antibiotic stewardship interventions. However, its effectiveness in reducing antimicrobial resistance is uncertain and a clear theoretical rationale for the approach is lacking. In this study, we sought to gain a mechanistic understanding of the relation between antibiotic treatment duration and the prevalence of colonisation with antibiotic-resistant bacteria in hospitalised patients. METHODS AND FINDINGS: We constructed 3 stochastic mechanistic models that considered both between- and within-host dynamics of susceptible and resistant gram-negative bacteria, to identify circumstances under which shortening antibiotic duration would lead to reduced resistance carriage...

This study examines family expenditures and how they respond to the provision of family cash transfers, particularly among higher-income families. Naming cash benefits with explicit reference to 'families' or 'children' can nudge households into labelling the extra cash for financial investments in children. Labelling has mainly been assessed among lower-income families. Yet if also higher-income families engage in labelling, there could be unintended consequences on the often stark disparities in child-related investments across the socio-economic divide...

The environmental challenges are currently placed at the forefront in order to achieve sustainable development. Although existing studies have largely examined the underlying factors of the environmental sustainability, the institutional quality and the role of information and communication technologies (ICTs) still insufficiently investigated. The aim of this paper is to clarify the role played by institutional quality and ICTs to mitigate environmental degradation at different scales of the ecological gap...

A perverse schober is a categorification of a perverse sheaf proposed by Kapranov-Schechtman. In this paper, we construct examples of perverse schobers on the Riemann sphere, which categorify the intersection complexes of natural local systems arising from the mirror symmetry for Calabi-Yau hypersurfaces. The Orlov equivalence plays a key role for the construction.

Lack of credibility and trust in fund managers has been highlighted as one of the key reasons why people do not join health insurance schemes in low- and middle-income countries, especially in Africa. This work investigates the impact of corruption on households' willingness to participate and pay for health insurance in Sierra Leone. A discrete choice experiment (DCE) method was used to elicit households' willingness to participate in a health insurance scheme with different attributes. The data were collected from 1458 representative households working in the informal sector of the Northern and Western regions...

INTRODUCTION: The term "paedophilia erotica" was first coined in 1886 by the psychiatrist Krafft-Ebing and it was considered a "psycho-sexual perversion." It was at the beginning of the twentieth century that the term "pedophilia" was adopted and it started to appear in medical dictionaries. Sexual abuse is legally defined as the engagement in sexual contact with a person below a specified age or who is incapable of giving consent. Both, pedophilia and child sexual abuse (CSA) are worldwide phenomena requiring deep scientific knowledge in order to improve prevention strategies...

Since 2020, Hungary's penalty law has banned any undue advantage or its promise for medical services. Parallel, the Health Care Act in force was changed concerning the legally acceptable allowances for medical care. Hungary's medical community and the patients received these changes as ending of the perverse informal payment system parasitizing the public financing. Informal payment disappeared indeed, but it will be hard to get rid of its ruins left behind. For creating transparency, first the health care workers' and general practitioners' quasi informal payment and finally the specialists' so-called parallel net-income (paid by patients' para-solvency) - which was an illegal fee for pretended private practice in the public health care - must be cleared...

There is increased concern about perverse incentives, quantitative performance metrics, and hyper-competition for funding and faculty positions in US academia. Recipients of the prestigious National Science Foundation Graduate Research Fellowships (n = 244) from Civil and Environmental Engineering (45.5%) and Computer Science and Engineering (54.5%) were anonymously surveyed to create a baseline snapshot of their perceptions, behaviors and experiences. NSF Fellows ranked scientific advancement as the top metric for evaluating academics followed by publishing in high-impact journals, social impact of research, and publication/citation counts...

We create a computational framework that utilizes loop extrusion (LE) by multiple condensin I/II motors to predict changes in chromosome organization during mitosis. The theory accurately reproduces the experimental contact probability profiles for the mitotic chromosomes in HeLa and DT40 cells. The LE rate is smaller at the start of mitosis and increases as the cells approach metaphase. Condensin II-mediated mean loop size is about six times larger than loops because of condensin I. The loops, which overlap each other, are stapled to a central dynamically changing helical scaffold formed by the motors during the LE process...