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https://www.readbyqxmd.com/read/29221810/mitochondrial-dysfunction-and-damage-associated-molecular-patterns-damps-in-chronic-inflammatory-diseases
#1
REVIEW
Charles S Dela Cruz, Min-Jong Kang
Inflammation represents a comprehensive host response to external stimuli for the purpose of eliminating the offending agent, minimizing injury to host tissues and fostering repair of damaged tissues back to homeostatic levels. In normal physiologic context, inflammatory response culminates with the resolution of infection and tissue damage response. However, in a pathologic context, persistent or inappropriately regulated inflammation occurs that can lead to chronic inflammatory diseases. Recent scientific advances have integrated the role of innate immune response to be an important arm of the inflammatory process...
December 5, 2017: Mitochondrion
https://www.readbyqxmd.com/read/29216558/maternal-support-following-childhood-sexual-abuse-relationships-to-child-reported
#2
Rachel Wamser-Nanney
Maternal support has been conceptualized as a key factor in predicting children's functioning following sexual abuse; however, empirical evidence for this assumption is rather limited. Prior studies may have failed to find a relationship between maternal support and children's outcomes due to the methodological weaknesses of the prior literature such as the use of maternal support measures without adequately reported psychometric properties. Moreover, relatively few studies have investigated whether maternal support corresponds with children's own self-reported symptoms...
December 4, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29214442/shiga-toxin-triggers-endothelial-and-podocyte-injury-the-role-of-complement-activation
#3
REVIEW
Carlamaria Zoja, Simona Buelli, Marina Morigi
Shiga toxin (Stx)-producing Escherichia coli (STEC) is the offending agent in post-diarrhea-associated hemolytic uremic syndrome (HUS), a disorder characterized by thrombocytopenia, microangiopathic hemolytic anemia, and acute kidney failure, with thrombi occluding the renal microvasculature. Endothelial dysfunction has been recognized as the trigger event in the development of microangiopathic processes. Glomerular endothelial cells are susceptible to the toxic effects of Stxs that, via nuclear factor kappa B (NF-κB) activation, induce the expression of genes encoding for adhesion molecules and chemokines, culminating in leukocyte adhesion and platelet thrombus formation on the activated endothelium...
December 6, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29214341/sternocostal-slipping-rib-syndrome
#4
Patrick C Bonasso, Shannon N Petrus, Samuel D Smith, Richard J Jackson
PURPOSE: Classical slipping rib syndrome (SRS) can be subclassified based on anatomical location. We describe our experience with three patients suffering from symptomatic sternocostal slipping rib syndrome (SCSRS), a much less common variant of SRS. METHODS: This was a retrospective review of patients with SRS from 1988 to 2016. Described is our experience. RESULTS: Of 44 patients identified with SRS, three patients underwent operations for SCSRS variant...
December 6, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29212706/phosphorylation-of-the-e3-ubiquitin-protein-ligase-itch-diminishes-binding-to-its-cognate-e2-ubiquitin-ligase
#5
Jessica M Perex, Tsan S Xiao, Derek W Abbott
Heightened and extended inflammation underlies the pathogenesis of many disorders, including inflammatory bowel disease, sepsis, and inflammatory arthritis. Ubiquitin networks help dictate the strength and duration of inflammatory signaling. In innate immunity, the itchy E3 ubiquitin protein ligase (ITCH-)-A20 ubiquitin--editing complex inhibits receptor-interacting Ser/Thr kinase (RIPK) activation by removing K63-Lys-63-linked polyubiquitinated chains from key proteins in the nuclear factor kappa B (NF-κB) signaling pathway...
December 6, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29212438/the-intensity-and-timing-of-sex-offender-treatment
#6
Andrew Day, Stuart Ross, Sharon Casey, James Vess, Diana Johns, Gaynor Hobbs
Current evidence about the impact of specialized sex offender treatment on reoffending remains inconsistent, drawing attention to the need to focus more on those program characteristics that potentially moderate outcome. This review considers current professional perspectives and evidence on two defining aspects of treatment: its intensity and timing. It is concluded that insufficient evidence currently exists to articulate best practice in this area and there is a pressing need to collect empirical evidence about the effectiveness of different intensity treatments offered at different stages of sentence...
December 1, 2017: Sexual Abuse: a Journal of Research and Treatment
https://www.readbyqxmd.com/read/29211735/-lowering-the-threshold-of-effective-deterrence-testing-the-effect-of-private-security-agents-in-public-spaces-on-crime-a-randomized-controlled-trial-in-a-mass-transit-system
#7
Barak Ariel, Matthew Bland, Alex Sutherland
Supplementing local police forces is a burgeoning multibillion-dollar private security industry. Millions of formal surveillance agents in public settings are tasked to act as preventative guardians, as their high visibility presence is hypothesized to create a deterrent threat to potential offenders. Yet, rigorous evidence is lacking. We randomly assigned all train stations in the South West of England that experienced crime into treatment and controls conditions over a six-month period. Treatment consisted of directed patrol by uniformed, unarmed security agents...
2017: PloS One
https://www.readbyqxmd.com/read/29209374/mental-health-assessment-of-south-korean-adults-on-probation
#8
Soungwan Kim, Bongseog Kim
Objective: The association of offender mental illness (including those on probation) with crime has long been the subject of social interest; however, systematic management has been insufficient. The study purpose was to analyze mental illness prevalence, proportion of first offenses and recidivism with the mental illness of those on probation. Methods: A total of 206 adults on probation were divided into groups (first offenders and repeat offenders) and they completed self-report instruments and clinical interviews designed to diagnose mental illness...
November 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/29207768/controversies-in-serotonin-syndrome-diagnosis-and-management-a-review
#9
REVIEW
Mohd Faisal Uddin, Richard Alweis, Syed Raza Shah, Noman Lateef, Waqas Shahnawaz, Rohan Kumar Ochani, Amin Muhammad Dharani, Syed Arbab Shah
Over the past few years, Serotonin Syndrome (SS) has become a significant clinical concern. Over the last decade, United States saw a surge in antidepressant use. SS characteristically presents as the triad of altered mental status, autonomic dysfunction and neuromuscular excitation. Symptoms vary from patient to patient with mild cases presenting with subacute symptoms and severe cases progressing rapidly to death. Due to the protean manifestations of the syndrome along with non-specific prodromal, SS can easily be misdiagnosed if not carefully assessed...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29204815/sadistic-offender-or-sexual-sadism-taxometric-evidence-for-a-dimensional-structure-of-sexual-sadism
#10
Nicholas Longpré, Jean-Pierre Guay, Raymond A Knight, Massil Benbouriche
Severe sexual sadism is a disorder of sexual preferences that focuses on humiliation and domination of the victim, sometimes causing grievous injury or death. Because offenders with high levels of sadism represent a risk to both reoffend and cause considerable harm should they reoffend, a diagnosis of sexual sadism has serious implications. The actual diagnosis of sexual sadism is fraught with problems (i.e., low reliability and validity) and exhibits poor consistency across assessments and studies (Levenson, 2004; Marshall, Kennedy, & Yates, 2002a)...
December 4, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/29203312/microvascular-decompression-for-treatment-of-trigeminal-neuralgia-factors-that-predict-complete-pain-relief-and-study-of-efficacy-and-safety-in-older-patients
#11
Sarun Nunta-Aree, Kasemsak Patiwech, Bunpot Sitthinamsuwan
OBJECTIVE: Microvascular decompression (MVD) is an effective method for directly treating the etiology of trigeminal neuralgia (TGN). This study aims to investigate the factors that predict complete pain relief after MVD for treatment of TGN, and to study efficacy and safety in older patients. METHODS: This study was conducted in patients with TGN that were treated by MVD at Siriraj Hospital during 2004-2015. Cases with secondary TGN were excluded. Data was gathered from medical records, preoperative magnetic resonance imaging (MRI), intraoperative findings, and by telephone in patients lost to follow-up...
December 1, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29203030/attitudes-toward-mandatory-ignition-interlocks-for-all-offenders-convicted-of-driving-while-intoxicated
#12
Jonathan Downs, Ruth Shults, Bethany West
INTRODUCTION: Ignition interlocks are effective in reducing alcohol-impaired driving recidivism for all offenders, including first-time offenders. Despite their effectiveness, interlock use among persons convicted of driving while intoxicated from alcohol (DWI) remains low. This cross-sectional survey of U.S. adults assessed public support for requiring ignition interlocks for all convicted DWI offenders including first-time offenders. The goal was to update results from a similar 2010 survey in light of new state requirements and increased interlock installations...
December 2017: Journal of Safety Research
https://www.readbyqxmd.com/read/29201637/two-patients-with-daptomycin-induced-eosinophilic-pneumonia-with-different-presentations-and-treatment
#13
Yonas Raru, Fuad Zeid, Shannon Browning, Elizabeth Saunders
We present two cases of daptomycin-induced eosinophilic pneumonia with characteristic chest x ray, CT scan and bronchoalveolar lavage (BAL) findings. It is not a commonly seen complication of Daptomycin but when it happens, it could cause a diagnostic and treatment dilemma. Patients could present acutely with hypoxic respiratory failure or a less dramatic chronic presentation is also possible. Our two patients presented with acute hypoxic respiratory failure and presentation resembles that of an infectious etiology...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29201554/linking-y-chromosomal-short-tandem-repeat-loci-to-human-male-impulsive-aggression
#14
Chun Yang, Huajie Ba, Yin Cao, Guoying Dong, Shuyou Zhang, Zhiqin Gao, Hanqing Zhao, Xianju Zhou
Introduction: Men are more susceptible to impulsive behavior than women. Epidemiological studies revealed that the impulsive aggressive behavior is affected by genetic factors, and the male-specific Y chromosome plays an important role in this behavior. In this study, we investigated the association between the impulsive aggressive behavior and Y-chromosomal short tandem repeats (Y-STRs) loci. Methods: The collected biologic samples from 271 offenders with impulsive aggressive behavior and 492 healthy individuals without impulsive aggressive behavior were amplified by PowerPlexRY23 PCR System and the resultant products were separated by electrophoresis and further genotyped...
November 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29201254/analyzing-gender-differences-in-the-relationship-between-family-influences-and-adolescent-offending-among-boys-and-girls
#15
E-L Nilsson
The aim of this paper is to examine gender differences in several dimensions of family-related variables in the explanation of adolescent offending. Analyses are conducted to examine: 1) whether boys and girls differ in levels of offending and in levels of family variables respectively, 2) whether the correlations between family variables and offending differ by gender, and 3) whether the family variables explain gender differences in adolescent offending. The study employs self-report data from a sample of young adolescents in Halmstad, Sweden (N = 889)...
2017: Child Indicators Research
https://www.readbyqxmd.com/read/29200972/problems-and-service-needs-among-ex-offenders-with-hiv-risk-behaviors-entering-sober-living-recovery-homes
#16
Douglas L Polcin, Rachael Korcha, Amy A Mericle, Elizabeth Mahoney, Jordana Hemberg
There is currently a nationwide effort to decrease the number of persons who are incarcerated in jails and prisons. However, many ex-offenders on probation or parole do not have access to affordable housing and larger proportions have histories of HIV risk as well as substance abuse problems. In California, sober living houses (SLHs) are becoming an increasingly popular housing option for these individuals. Based largely on the principles of Alcoholics Anonymous (AA), SLHs require abstinence from alcohol and drugs and provide peer support for recovery...
2017: Criminal Justice Studies (Abingdon, England)
https://www.readbyqxmd.com/read/29200931/systematic-review-of-early-risk-factors-for-life-course-persistent-adolescence-limited-and-late-onset-offenders-in-prospective-longitudinal-studies
#17
Darrick Jolliffe, David P Farrington, Alex R Piquero, Rolf Loeber, Karl G Hill
This paper builds on our previous systematic review of prospective longitudinal studies and examines the early risk factors associated with life-course persistent offending (LCP), adolescence-limited (AL) and late-onset (LO) offending. Out of the 55 prospective longitudinal studies which theoretically could possess the relevant information, only four provided information about risk factors associated with the different offending types. An additional three provided data so that relevant analyses could be conducted...
March 2017: Aggression and Violent Behavior
https://www.readbyqxmd.com/read/29200480/stitchless-percutaneous-endoscopic-cervical-discectomy-are-we-moving-towards-day-care-discectomy-procedure
#18
Sunil M Nadkarni, Pavankumar Kohli, Bhupesh Patel, Satishchandra Gore, Bhagyashree S Kulkarni
Background: STITCHLESS percutaneous endoscopic cervical discectomy s[PECD] is safe, precise, targeted, and a complete endoscopic procedure to treat soft cervical disc herniation with unilateral radiculopathy. It allows direct visualization of herniated fragment and its removal, inspection of decompressed nerve root in an awake and aware patient. It reduces the risk related to general anesthesia and to the neurological structures. However, all the patients treated with PECD can be candidates for anterior cervical discectomy and fusion (ACDF)...
November 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29199502/adhd-among-offenders-prevalence-and-relationship-with-psychopathic-traits
#19
Ana Machado, Diana Rafaela, Tânia Silva, Tânia Veigas, Joaquim Cerejeira
OBJECTIVE: Longitudinal studies have shown a strong association between ADHD and criminal behavior. The aims of this study were to examine the prevalence of adult ADHD in a high-security facility and to investigate the relationship between ADHD symptoms and psychopathic traits in criminal offenders. MATERIAL AND METHODS: Participants were recruited between October 2015 and January 2016 among the inmates from a high-security all-male correctional facility in Portugal...
December 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/29198698/successful-intravenous-immunoglobulin-treatment-in-pediatric-severe-dress-syndrome
#20
Nufar Marcus, Keren Smuel, Moran Almog, Dario Prais, Rachel Straussberg, Daniel Landau, Oded Scheuerman
BACKGROUND: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare, potentially life-threatening delayed drug-induced hypersensitivity reaction. The most frequently reported drugs causing DRESS are aromatic antiepileptic agents. Prompt withdrawal of the offending drug and administering systemic corticosteroids is the most widely accepted and used treatment. The treatment of severe DRESS not responsive to systemic corticosteroids is uncertain. OBJECTIVE: The objective of this study was to describe a case series of pediatric patients with DRESS who were treated successfully with intravenous immunoglobulins (IVIGs)...
November 30, 2017: Journal of Allergy and Clinical Immunology in Practice
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