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https://www.readbyqxmd.com/read/29670677/clinical-outcomes-of-extended-spectrum-beta-lactamase-producing-enterobacteriaceae-infections-with-susceptibilities-among-levofloxacin-cefepime-and-carbapenems
#1
Kristy J Walker, Young R Lee, Amanda R Klar
Purpose: Highly resistant Gram-negative bacterial infections are associated with high mortality. Increasing resistance to standard therapy illustrates the need for alternatives when treating resistant organisms, especially extended-spectrum beta-lactamase- (ESBL-) producing Enterobacteriaceae . Methods: A retrospective chart review at a community hospital was performed. Patients who developed ESBL-producing infections were included. Patients less than eighteen years old, who were pregnant, or who were incarcerated were excluded...
2018: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/29666075/rogue-one-a-story-of-tophaceous-gout-in-the-spine
#2
Karthik Dwarki, Andy Dothard, Bryan Abadie, Matthew C Miles
A 26-year-old man with history of extensive tophaceous gout presented to the referring facility with decreased bilateral lower extremity sensation and motor function that began acutely 1 week prior to admission and had progressed to urinary incontinence. The patient was admitted to the intensive care unit due to concern for sepsis secondary to epidural abscess. The patient was started on empiric vancomycin and cefepime. Neurosurgery did not recommend acute neurosurgical intervention given the lack of a compressive lesion...
April 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29662672/results-of-a-local-combination-therapy-antibiogram-for-pseudomonas-aeruginosa-isolates-is-double-worth-the-trouble
#3
Matthew Song, Thomas J Dilworth, Erik Munson, Jim Davis, Ramy H Elshaboury
Purpose: To determine the frequency at which fluoroquinolones and aminoglycosides demonstrate in vitro activity against non-urinary, non-skin/skin structure Pseudomonas aeruginosa isolates exhibiting decreased susceptibilities to one or more β-lactam agents. Methods: β-lactam-non-susceptible P. aeruginosa isolates recovered from blood, bone, lower respiratory tract, pleural fluid, cerebrospinal fluid, or peritoneal fluid cultures between October 2010 and October 2014 were reviewed from four community hospitals within a single health-system...
November 2017: Therapeutic Advances in Infectious Disease
https://www.readbyqxmd.com/read/29627985/strategic-approaches-to-overcome-resistance-against-gram-negative-pathogens-using-%C3%AE-lactamase-inhibitors-and-%C3%AE-lactam-enhancers-the-activity-of-three-novel-diazabicyclooctanes-wck-5153-zidebactam-wck-5107-and-wck-4234
#4
Krisztina M Papp-Wallace, Nhu Q Nguyen, Michael R Jacobs, Christopher R Bethel, Melissa D Barnes, Vijay Kumar, Saralee Bajaksouzian, Susan D Rudin, Philip N Rather, Satish Bhavsar, Tadiparthi Ravikumar, Prasad K Deshpande, Vijay Patil, Ravindra Yeole, Sachin S Bhagwat, Mahesh V Patel, Focco van den Akker, Robert A Bonomo
Limited treatment options exist to combat infections caused by multidrug-resistant (MDR) Gram negative bacteria possessing broad-spectrum β-lactamases. The design of novel β-lactamase inhibitors is of paramount importance. Here, three novel diazabicyclooctanes (DBOs), WCK 5153, zidebactam (WCK 5107), and WCK 4234 (compounds 1-3) were synthesized and biochemically characterized against clinically important bacteria. Compound 3 inhibited class A, C and D β-lactamases with unprecedented k2/K values against OXA carbapenemases...
April 7, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29626525/whole-genome-sequence-of-an-mcr-1-carrying-esbl-producing-escherichia-coli-st746-isolate-recovered-from-community-acquired-urinary-tract-infection
#5
Lingjiao Wu, Jing Chen, Li Wang, Zhe Wu
OBJECTIVES: Colistin is regarded as one of the last-resort antimicrobials for severe infections. Plasmid-borne mobile colistin resistance gene (mcr-1)-carrying isolates were rarely reported in community-acquired infections. Here we report the draft genome sequence of an MCR-1-carrying, extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolate from community-acquired urinary tract infection. MTHODS: Antimicrobial susceptibility tests (AST) were determined by the broth microdilution method...
April 4, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29625107/cephalosporin-antibiotics-are-weak-blockers-of-gabaa-receptor-mediated-synaptic-transmission-in-rat-brain-slices
#6
Dmitry V Amakhin, Elena B Soboleva, Aleksey V Zaitsev
Cephalosporins are beta-lactam antibiotics that are extensively used in medical practice and are reported to cause epileptic seizures in some patients. The primary cause of cephalosporin-induced convulsions is believed to be their ability to block GABAa receptors. However, direct evidence for the involvement of this mechanism has not yet been provided. The present study aims to investigate the ability of two cephalosporins - cefepime and ceftriaxone - to block inhibitory synaptic transmission in entorhinal cortex slices of rats...
April 3, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29609277/-analysis-of-distribution-and-drug-resistance-of-pathogens-of-burn-patients-during-9-years
#7
Y Dou, Q Zhang
Objective: To investigate distribution and drug resistance of pathogens of burn patients. Methods: A total of 3 357 strains were cultured and isolated from 25 286 specimens of wounds excretion, deep venous catheters, venous blood, stool, mid-stream urine, sputum, puncture fluid, and throat swab of 11 510 burn patients hospitalized in our burn wards from January 2007 to December 2015. After being identified by API bacteria identification panels and automatically bacteria identification equipment, drug-resistances of Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae to 28 common antibiotics were tested by drug sensitivity test with K-B paper disk diffusion method...
March 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29592981/burn-aggravated-infected-wart-in-a-patient-with-type-2-diabetes-a-medical-challenge
#8
Tahseen Ahmed Khan, Mahmood Sheikh, Iqbal Azher, Abdul Khaliq Sheikh
An infectious wart of foot in a patient with diabetics is a medical challenge, and it gets worse when aggravated with burns. We present a case of a 67-year-old Pakistani man, diabetic for 20 years presented at our healthcare centre. While awaiting his culture sensitivity report, he was prescribed an empiric antibiotic therapy. Patient then travelled to Saudi Arabia for pilgrimage 3 days later with growth of Staphylococcus aureus and Proteus species in culture and sensitivity report; during his travel, he walked barefoot and the infected wart aggravated with severe burn...
March 28, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29590376/incidence-of-nephrotoxicity-among-pediatric-patients-receiving-vancomycin-with-either-piperacillin-tazobactam-or-cefepime-a-cohort-study
#9
Kathryn M Cook, Jessica Gillon, Alison G Grisso, Ritu Banerjee, Natalia Jimenez-Truque, Elizabeth J Phillips, Sara L Van Driest
Background: Recent studies in adults have found an incidence of acute kidney injury (AKI) in patients treated with a combination of vancomycin and piperacillin-tazobactam (TZP) that is greater than that expected with either medication alone. The purpose of this study was to determine whether combination therapy with vancomycin and TZP is associated with an incidence of AKI in pediatric patients higher than that in those on combination therapy with vancomycin and cefepime. Methods: We performed a retrospective single-center matched-cohort study of pediatric patients who received vancomycin in combination with TZP or cefepime between January 2015 and June 2016...
March 26, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29577355/simultaneous-determination-of-zidebactam-and-cefepime-in-dog-plasma-by-lc-ms-ms-and-its-application-to-pre-clinical-pharmacokinetic-study
#10
Kiran Patil, Harshad Tambe, Vineet Zope, Rajesh Chavan, Ravindra Yeole, Mahesh Patel
A precise and accurate liquid chromatography-tandem mass spectrometric (LC-MS/MS) bioanalytical method has been developed and validated for the simultaneous quantification of Zidebactam (ZID) and Cefepime (FEP) in dog plasma. Ceftazidime was used as an internal standard. Protein precipitation method was used as sample preparation approach. The calibration curve obtained was linear (r ≥ 0.99) over the concentration range of 0.156-80 μg/mL for ZID and 0.312-160 μg/mL for FEP. Method was validated as per FDA guideline and the results met the acceptance criteria...
March 25, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29575185/identification-of-vim-2-metallo-%C3%AE-lactamase-producing-pseudomonas-aeruginosa-isolated-from-dogs-with-pyoderma-and-otitis-in-korea
#11
Jae-Eun Hyun, Tae-Ho Chung, Cheol-Yong Hwang
BACKGROUND: Pseudomonas aeruginosa is a challenging pathogen cultured from cases of acute and chronic canine otitis and sometimes in cases of deep pyoderma. The spread of antimicrobial resistance, especially carbapenem resistance, is a serious therapeutic challenge worldwide. HYPOTHESIS/OBJECTIVES: To investigate the identification and characterization of resistant P. aeruginosa clinical canine isolates. MATERIALS: Clinical isolates (n = 80) were collected from dogs with pyoderma (n = 18) and otitis (n = 62) in Korea...
March 25, 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/29568806/antibiotic-resistance-patterns-of-urinary-tract-pathogens-in-turkish-children
#12
Suzan Gunduz, Hatice Uludağ Altun
Background: Knowledge of local antimicrobial resistance patterns is essential for evidence- based empirical antibiotic prescribing. We aimed to investigate the distribution and changes in causative agents of urinary tract infections in children and the resistance rates, and to recommend the most appropriate antibiotics. Methods: In this retrospective study, we evaluated causative agents and antimicrobial resistance in urine isolates from the positive community from September 2014 to April 2016 in a single hospital in Ankara, Turkey...
2018: Global health research and policy
https://www.readbyqxmd.com/read/29560346/cefepime-efficacy-and-safety-in-children-a-systematic-review-and-meta-analysis
#13
Saber Jan, Braveen Ragunanthan, Sandra R DiBrito, Omolabake Alabi, Maria Gutierrez
Background: Cefepime is a fourth-generation cephalosporin antibiotic used to treat a variety of infections. The US Food and Drug Administration approved its use in certain types of infections among pediatric patients, and yet there have been mixed data about its efficacy and safety in this population. Objective: The objective of this review is to compare efficacy and all-cause mortality of cefepime to other clinically indicated antibiotics among children. Methods: We conducted a systematic search of MEDLINE, EMBASE, CENTRAL, LILACS, and clinicaltrials...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29555635/beta-lactams-combinations-with-vancomycin-provide-synergy-against-vssa-hvisa-and-visa
#14
Kieu-Nhi Tran, Michael J Rybak
Background: Increasing utilization of vancomycin due to the high prevalence of methicillin-resistant S. aureus (MRSA) infections has lead to the emergence of vancomycin-intermediate S. aureus (VISA) and heterogeneous VISA (hVISA). In vitro data suggest the potential for potent synergy between several beta-lactams and vancomycin. The objective of this study is to evaluate the synergy between beta-lactams and vancomycin against MRSA that is vancomycin susceptible, vancomycin susceptible Staphylococcus aureus (VSSA), hVISA, and VISA...
March 19, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29555391/antimicrobial-susceptibility-of-common-pathogens-isolated-from-postoperative-intra-abdominal-infections-in-japan
#15
Yoshio Takesue, Shinya Kusachi, Hiroshige Mikamo, Junko Sato, Akira Watanabe, Hiroshi Kiyota, Satoshi Iwata, Mitsuo Kaku, Hideaki Hanaki, Yoshinobu Sumiyama, Yuko Kitagawa, Kazuhiko Nakajima, Takashi Ueda, Motoi Uchino, Toru Mizuguchi, Yoshiyasu Ambo, Masafumi Konosu, Keiichiro Ishibashi, Akihisa Matsuda, Kazuo Hase, Yasushi Harihara, Koji Okabayashi, Shiko Seki, Takuo Hara, Koshi Matsui, Yoichi Matsuo, Minako Kobayashi, Shoji Kubo, Kazuhisa Uchiyama, Junzo Shimizu, Ryohei Kawabata, Hiroki Ohge, Shinji Akagi, Masaaki Oka, Toshiro Wakatsuki, Katsunori Suzuki, Kohji Okamoto, Katsunori Yanagihara
The principle of empirical therapy for patients with intra-abdominal infections (IAI) should include antibiotics with activity against Enterobacteriaceae and Bacteroides fragilis group species. Coverage of Pseudomonas aeruginosa, Enterobacter cloacae, and Enterococcus faecalis is also recommended for hospital-associated IAI. A nationwide survey was conducted to investigate the antimicrobial susceptibility of pathogens isolated from postoperative IAI. All 504 isolates were collected at 26 institutions and referred to a central laboratory for susceptibility testing...
March 16, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29551974/neurobehavioral-effects-of-cephalosporins-assessment-of-locomotors-activity-motor-and-sensory-development-in-zebrafish
#16
Ying Han, Yangmin Zheng, Jingpu Zhang, Changqin Hu
Most third- and fourth-generation cephalosporins, such as cefotaxime, cefmenoxime, cefepime, and cefpirome, contain an aminothiazoyl ring at the C-7 position. Drug impurity, which may be produced either during synthesis or upon degradation, can induce adverse effects. Various reports have indicated that neurotoxicity is a side effect of cephalosporin. In this study, we developed methods for assessing the free-swimming activities and behaviors in zebrafish larvae in response to continuous darkness and stimulation of light-to-dark photoperiod transition by chemical treatments...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29529677/escherichia-coli-and-klebsiella-pneumoniae-sensitivity-resistance-pattern-towards-antimicrobial-agents-in-primary-and-simple-urinary-tract-infection-patients-visiting-university-hospital-of-jamia-hamdard-new-delhi
#17
Mohd Rizwan, Mohd Akhtar, Abul Kalam Najmi, Kuldeep Singh
AIM: This study was carried out to record the sensitivity/resistance pattern of Escherichia coli and Klebsiella pneumoniae towards antimicrobial drugs prescribed to urinary tract infection (UTI) patients. MATERIALS AND METHODS: A total of 68 bacteriologically proven simple UTI patients were included in the study, based on inclusion and exclusion criteria. Subjects demographics, antibiotics prescribed, sensitivity pattern of antibiotics towards the urinary pathogens were recorded in drug utilization and documentation form...
March 12, 2018: Drug Research
https://www.readbyqxmd.com/read/29525799/determination-of-antibiotic-resistance-pattern-and-prevalence-of-oxa-type-carbapenemases-among-acinetobacter-baumannii-clinical-isolates-from-inpatients-in-isfahan-central-iran
#18
Aliakbar Rezaei, Hossein Fazeli, Mehdi Moghadampour, Mehrdad Halaji, Jamshid Faghri
Acinetobacter baumannii is one of the most important bacterial species with the ability to produce OXA-type carbapenemases. We aimed to evaluate the prevalence of OXA-type carbapenemases among clinical isolates of A. baumannii in three major hospitals of Isfahan. In this cross-sectional descriptive study, 153 non-repeated strains of A. baumannii were isolated from various clinical samples of hospitalized patients in Al-Zahra, Imam Mousa Kazem, and Shariati hospitals from October 2015 to October 2016. Antimicrobial susceptibility testing for imipenem, meropenem, ertapenem, cefepime, ceftazidime, ceftriaxone, piperacillin-tazobactam, gentamicin, amikacin, ciprofloxacin, and tetracycline was performed using the disk diffusion method...
March 1, 2018: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/29517808/incidence-of-cephalosporin-induced-anaphylaxis-and-clinical-efficacy-of-screening-intradermal-tests-with-cephalosporins-a-large-multicenter-retrospective-cohort-study
#19
Min-Suk Yang, Dong-Yoon Kang, Bomi Seo, Hye Jung Park, So-Young Park, Mi-Yeong Kim, Kyung Hee Park, So-My Koo, Young-Hee Nam, Sujeong Kim, Jae-Woo Jung, Tae-Bum Kim, Gwang Cheon Jang, Hyeon-Jong Yang, Young-Min Ahn, Jung-Won Park, Hye-Ryun Kang
BACKGROUND: Few studies have investigated the incidence of anaphylaxis induced by individual or structurally similar cephalosporins. The aims of the study were to assess the incidence of cephalosporin-induced anaphylaxis and evaluate the clinical efficacy of screening skin tests. METHODS: In this retrospective cohort study, we obtained information on total cephalosporin use and cephalosporin-induced anaphylaxis in intravenous cephalosporin recipients in 12 general hospitals between 2013 and 2015...
March 8, 2018: Allergy
https://www.readbyqxmd.com/read/29495161/-study-on-antimicrobial-susceptibility-of-brucella-in-a-city
#20
S W Zuo, Z L Ni, Y B Yao, R S Yang, S K Wang, Y H Zhou
Objective: To investigate the antimicrobial susceptibility of Brucella and to provide a scientific basis for rational drug use and effective treatment of patients with brucellosis. Methods: A total of 41 Brucella strains were isolated from the blood of patients with brucellosis in 5 counties and 2 districts in Yuxi City, China from 2014 to 2016. The susceptibility to 23 antimicrobial drugs was tested using Kirby-Bauer (K-B) disk diffusion method and the sizes of antimicrobial rings were recorded. The susceptibility testing results were interpreted according to the Drug Susceptibility Testing Guideline (2009 version) ...
December 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
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