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Cefepime

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https://www.readbyqxmd.com/read/29046121/cefepime-intravenous-push-versus-intravenous-piggyback-on-time-to-administration-of-first-dose-vancomycin-in-the-emergency-department
#1
Ann Tran, David O'Sullivan, Michelle Krawczynski
STUDY OBJECTIVE: The combination of cefepime and vancomycin is commonly used as an empiric antimicrobial regimen. Time to first-dose antibiotics is associated with survival benefit. The objective of this study is to evaluate whether cefepime intravenous push (IVP) is associated with a shorter time to vancomycin administration in the emergency department (ED) compared with cefepime intravenous piggyback (IVPB) infusion. METHODS: This was a retrospective chart review of records of patients who were treated with the vancomycin-cefepime combination in the ED...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29036990/-drug-resistance-and-dissemination-of-new-delhi-metallo-%C3%AE-lactamase-1-positive-bacteria-in-a-patient
#2
X F Zhao, M Yuan, X Chen, X F Liu, D S Yu, J Li
Objective: The aim of this work was to report the surveillance and dissemination of NDM-1 positive bacteria in a patient and ward environment. Methods: In 2010, during the therapy for a 51 years old patient, clinical and environmental samples were collected for carbapenem resistant bacterial culture, according to the clinical microbiological examination. Strains identification and antibiotic susceptibility were tested by VITEK Compact 2 system and E-test. The bla(NDM-1) was detected by PCR and analyzed by sequencing...
October 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29031525/impact-of-clsi-and-eucast-cefepime-breakpoint-changes-on-the-susceptibility-reporting-for-enterobacteriaceae
#3
Jacqueline T Bork, Emily L Heil, Surbhi Leekha, Randal C Fowler, Nancy D Hanson, Anjali Majumdar, J Kristie Johnson
OBJECTIVE: We analyzed the effects of different cefepime MIC breakpoints on Enterobacteriaceae cefepime susceptibility and the presence of AmpC and extended-spectrum β-lactamase (ESBL) genes within the cefepime MIC interpretative categories. METHODS: Using Enterobacteriaceae susceptibility data from 2013 comparisons of MIC breakpoints were performed using Pearson's chi-squared test. Molecular testing on a subset of isolates was done. RESULTS: Among 3784 non-duplicate clinical isolates, cefepime susceptibility decreased from 97...
October 11, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29026394/quorum-sensing-inhibitory-activity-of-sub-inhibitory-concentrations-of-%C3%AE-lactams
#4
Somaia A El-Mowafy, Khaled H Abd El Galil, El-Sayed E Habib, Mona I Shaaban
INTRODUCTION: The virulence factors of Pseudomonas aeruginosa are under the control of quorum sensing (QS) signals. Hence, interference with QS prevents its pathogenesis. OBJECTIVE: The aim of the present research is to assess the influence of some β-lactam antibiotics on cell communication and the release of different virulence factors. METHODS: The minimal inhibitory concentrations of ceftazidime, cefepime and imipenem were evaluated by microbroth dilution method...
March 2017: African Health Sciences
https://www.readbyqxmd.com/read/29020294/predicting-resistance-to-piperacillin-tazobactam-cefepime-and-meropenem-in-septic-patients-with-bloodstream-infection-due-to-gram-negative-bacteria
#5
M Cristina Vazquez-Guillamet, Rodrigo Vazquez, Scott T Micek, Marin H Kollef
Background: Predicting antimicrobial resistance in gram-negative bacteria (GNB) could balance the need for administering appropriate empiric antibiotics while also minimizing the use of clinically unwarranted broad-spectrum agents. Our objective was to develop a practical prediction rule able to identify patients with GNB infection at low risk for resistance to piperacillin-tazobactam (PT), cefepime (CE), and meropenem (ME). Methods: The study included adult patients with sepsis or septic shock due to bloodstream infections caused by GNB admitted between 2008 and 2015 from Barnes-Jewish Hospital...
July 10, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28993338/activity-of-ceftolozane-tazobactam-and-ceftazidime-avibactam-against-beta-lactam-resistant-pseudomonas-aeruginosa-isolates
#6
Romney M Humphries, Janet A Hindler, Annie Wong-Beringer, Shelley A Miller
Ceftolozane-tazobactam (C/T) and ceftazidime-avibactam (CZA) minimum inhibitory concentrations were evaluated for a collection of 309 beta-lactam resistant isolates of Pseudomonas aeruginosa recovered from three institutions in Los Angeles, CA. Overall, 12.0% of isolates were susceptible to imipenem, 15.9% to meropenem, 20.7% to piperacillin-tazobactam, 24.6% to ceftazidime and 25.9% to cefepime, 72.5% to C/T and 61.8% to CZA. Among C/T-resistant isolates, 9.1% were CZA-susceptible, whereas 36.4% of CZA-resistant isolates were susceptible to C/T...
October 9, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28993143/ceftolozane-tazobactam-activity-against-drug-resistant-enterobacteriaceae-and-pseudomonas-aeruginosa-causing-health-care-associated-infections-in-the-asia-pacific-region-apac-minus-china-australia-and-new-zealand-report-from-an-antimicrobial-surveillance-program
#7
M A Pfaller, D Shortridge, H S Sader, M Castanheira, R K Flamm
OBJECTIVES: To evaluate the in vitro activity of ceftolozane-tazobactam and comparator agents tested against Enterobacteriaceae and Pseudomonas aeruginosa isolates from patients in the Asia-Pacific region (APAC) with health care associated infections (HAI). Ceftolozane-tazobactam is an antipseudomonal cephalosporin combined with a well-established β-lactamase inhibitor. METHODS: A total of 1,963 gram-negative organisms (489 P. aeruginosa and 1,474 Enterobacteriaceae) were consecutively collected using a prevalence-based approach from 14 medical centers in the APAC region...
October 6, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28971862/efficacy-of-ceftriaxone-cefepime-doxycycline-ciprofloxacin-and-combination-therapy-for-vibrio-vulnificus-foodborne-septicemia
#8
Sonya A Trinh, Hannah E Gavin, Karla J F Satchell
Vibrio vulnificus foodborne infections have higher rates of sepsis and mortality compared to wound infections; however, antibiotic efficacy studies have not been performed in foodborne infection models. The efficacy of ceftriaxone, cefepime, doxycycline, ciprofloxacin, and combination therapy was assessed in a V. vulnificus intestinal infection in mice to model foodborne infections. Consistent with prior studies of cefotaxime, cefepime was synergistic with doxycycline and ciprofloxacin in vitro; combination therapy significantly decreased bacterial growth by ≥2log10 compared to antibiotic monotherapy (p<0...
October 2, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28969934/enhanced-activity-of-cefepime-tazobactam-wck-4282-against-kpc-producing-enterobacteriaceae-when-tested-in-media-supplemented-with-human-serum-or-sodium-chloride
#9
Mariana Castanheira, Leonard R Duncan, Paul R Rhomberg, Helio S Sader
The aim of this study was to evaluate the in vitro activity of cefepime-tazobactam cation-adjusted Mueller-Hinton broth (CA-MHB) supplemented with 0.85% sodium chloride (NaCl) or 50% human serum in comparison to standard CA-MHB when testing KPC-producing isolates. A total of 209 contemporary Enterobacteriaceae clinical isolates carrying blaKPC were tested, and cefepime-tazobactam (tazobactam at fixed 8mg/L) activity was enhanced 2-fold when tested in CA-MHB supplemented with 0.85% NaCl or 50% human serum (MIC50/90, 8/32mg/L for both media) compared to standard CA-MHB (MIC50/90, 16/64mg/L)...
August 24, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28950805/risk-factors-for-cefepime-nonsusceptible-gram-negative-infections-in-allogeneic-hematopoietic-cell-transplant-recipients
#10
A M Boyd, A J Perissinotti, J L Nagel, D G Frame, B L Marini
Purpose Allogeneic hematopoietic cell transplant recipients undergo myelosuppressive chemotherapy to allow engraftment of stem cells and are at particularly high risk for bacterial infections and adverse outcomes. Patients undergoing hematopoietic cell transplant are at increased risk for healthcare-associated infections, including infections with multidrug-resistant pathogens. Cefepime is a commonly prescribed antibiotic for empiric therapy in hematopoietic cell transplant patients, but there is minimal data describing cefepime resistance rates, risk factors for resistance, and clinical outcomes associated with cefepime-resistant infections...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/28947475/pharmacokinetics-pharmacodynamics-of-tazobactam-in-combination-with-cefepime-in-an-in-vitro-infection-model
#11
Brian D VanScoy, David Tenero, Simon Turner, David M Livermore, Jennifer McCauley, Haley Conde, Sujata M Bhavnani, Christopher M Rubino, Paul G Ambrose
We previously demonstrated that for tazobactam administered in combination with ceftolozane, the pharmacokinetic-pharmacodynamic (PK-PD) index that best described tazobactam efficacy was the percentage of the dosing interval that tazobactam concentrations were above a threshold (%T>threshold). Using data from studies of Enterobacteriaceae-producing ESBL, a relationship between tazobactam %T>threshold and reduction in log10 CFU from baseline, for which tazobactam threshold concentration was the product of the isolate's ceftolozane-tazobactam MIC value and 0...
September 25, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28947474/pharmacokinetics-pharmacodynamics-of-cb-618-in-combination-with-cefepime-ceftazidime-ceftolozane-and-meropenem-the-pharmacological-basis-for-a-stand-alone-%C3%AE-lactamase-inhibitor
#12
Paul G Ambrose, Brian D VanScoy, Michael Trang, Jennifer McCauley-Miller, Haley Conde, Sujata M Bhavnani, Dylan C Alexander, Lawrence V Friedrich
A major challenge in treating patients is the selection of the "right" antibiotic regimen. Given that the optimal β-lactam-β-lactamase inhibitor pair is dependent upon the spectrum of β-lactamase enzymes produced and the frequency of resistance to the β-lactamase inhibitor, it might be useful if a stand-alone were available for the clinician to pair with the "right" β-lactam rather than only in a fixed combination. In this communication, we describe a one-compartment in vitro infection model studies conducted to identify the magnitude of the pharmacokinetic-pharmacodynamic (PK-PD) index for a β-lactamase inhibitor, CB-618, that would restore the activity of four β-lactam partner agents (cefepime, ceftazidime, ceftolozane, and meropenem) with varying dose (1 or 2 g) and dosing intervals (8 or 12 h)...
September 25, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28946125/a-simple-ultra-high-performance-liquid-chromatography-high-resolution-mass-spectrometry-assay-for-the-simultaneous-quantification-of-15-antibiotics-in-plasma
#13
S Lefeuvre, J Bois-Maublanc, L Hocqueloux, L Bret, T Francia, C Eleout-Da Violante, E M Billaud, F Barbier, L Got
Antibiotic (ATB) treatment of critically ill patients with pathophysiological injuries remains a challenge due to the constant increase in antimicrobial resistance. Therapeutic drug monitoring (TDM) is advised for ATB dose adjustments to avoid suboptimal concentrations and dose-related adverse effects. Therefore, a single and reliable analytical method for a broad selection of ATBs was developed using a high-resolution mass spectrometry (HRMS) platform for frequent use in intensive care units. An UHPLC assay coupled to high resolution accurate mass acquisition has been developed for the quantification of penicillins (amoxicillin, oxacillin, piperacillin, and ticarcillin), cephalosporines (cefepime, cefotaxime, ceftazidime, and ceftriaxone), carbapenems (ertapenem, imipenem, and meropenem), lincosamide (clindamycin), quinolones (ofloxacin and ciprofloxacin) and tazobactam...
September 11, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28943367/cefepime-versus-carbapenems-for-the-treatment-of-urinary-tract-infections-caused-by-extended-spectrum-beta-lactamase-producing-enterobacteriaceae
#14
Se Ah Kim, Jerry Altshuler, Daryl Paris, Marianna Fedorenko
OBJECTIVES: The objective of this study was to evaluate the effectiveness of cefepime compared to carbapenems for the management of urinary tract infections (UTIs) caused by extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae. METHODS: This was a single-center retrospective study among patients with a documented ESBL-producing Enterobacteriaceae UTI between July 1, 2014 and January 31, 2017. Adult patients who received either cefepime or a carbapenem for symptomatic UTI were included in the analysis...
September 21, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28941394/ceftolozane-tazobactam-activity-against-drug-resistant-enterobacteriaceae-and-pseudomonas-aeruginosa-causing-healthcare-associated-infections-in-latin-america-report-from-an-antimicrobial-surveillance-program-2013-2015
#15
Michael A Pfaller, Dee Shortridge, Helio S Sader, Ana Gales, Mariana Castanheira, Robert K Flamm
This study evaluated the in vitro activity of ceftolozane-tazobactam and comparator agents tested against Latin American isolates of Enterobacteriaceae and Pseudomonas aeruginosa from patients with healthcare-associated infection (HAI). Ceftolozane-tazobactam is an antipseudomonal cephalosporin combined with a well-established β-lactamase inhibitor. A total of 2415 Gram-negative organisms (537 P. aeruginosa and 1878 Enterobacteriaceae) were consecutively collected in 12 medical centers located in four Latin American countries...
September 20, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28941393/mobile-health-application-to-assist-doctors-in-antibiotic-prescription-an-approach-for-antibiotic-stewardship
#16
Felipe Francisco Tuon, Juliano Gasparetto, Luciana Cristina Wollmann, Thyago Proença de Moraes
BACKGROUND: Technologies applied to mobile devices can be an important strategy in antibiotic stewardship programs. OBJECTIVE: The aim of this study was to determine the impact of a decision-making application on antibiotic prescription. METHODS: This was an observational, analytical and longitudinal study on the implementation of an antimicrobial guide for mobile application (app). This study analyzed the period of 12 months before and 12 months after the app implementation at a university hospital based on local epidemiology, avoiding high cost drugs and reducing the potential for drug resistance including carbapenem...
September 20, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28936955/-analysis-of-characteristics-of-bacteria-in-respiratory-tract-infection-in-2013-2016-in-heibei-3a-hospital-a-single-center-report-of-7-497-patients
#17
Lili Hou, Lili Liu, Ping Dang, Guannan Kang, Qinfeng Zhang, Dongling Li
OBJECTIVE: To analyze the changes and characteristics of respiratory tract bacteria in Hebei 3A Hospital, and to provide new rationale for clinical diagnosis and treatment. METHODS: A single-center retrospective analysis was conducted. 7 497 patients with respiratory tract infection admitted to Hebei Chest Hospital from January 2013 to December 2016 were enrolled. Deep sputum was collected, and the bacterial cultures and susceptibility analysis was conducted in sputum and upper respiratory secretions were collected by fiberoptic bronchoscopy...
September 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28932712/multidrug-and-co-resistance-patterns-of-non-fermenting-gram-negative-bacilli-involved-in-ventilator-associated-pneumonia-carrying-class-1-integron-in-the-north-of-iran
#18
Masoumeh Bagheri-Nesami, Mohammad Sadegh Rezai, Fatemeh Ahangarkani, Alireza Rafiei, Attieh Nikkhah, Gohar Eslami, Kheironesa Shafahi, Azin Hajalibeig, Rezvan Khajavi
INTRODUCTION: Ventilator-associated pneumonia (VAP) due to non-fermenting Gram-negative bacilli (NFGNB), especially Pseudomonas aeruginosa and Acinetobacter spp., is one of the main hospital-acquired infections leading to mortality and morbidity, especially in intensive care units (ICUs). This study seeks to determine the multidrug and co-resistance (MDR) patterns of NFGNB that are agents of VAP, and assess the presence of class 1 integron in these bacteria. METHODS: This cross-sectional study involved VAP patients admitted in the ICUs of 18 hospitals in the Mazandaran province, located in the North of Iran...
September 2017: Germs
https://www.readbyqxmd.com/read/28923865/an-in-vitro-comparison-of-ceftolozane-tazobactam-compared-to-traditional-beta-lactams-as-an-alternative-to-combination-antimicrobial-therapy-for-pseudomonas-aeruginosa
#19
Kellie J Goodlet, David P Nicolau, Michael D Nailor
Background: Guidelines for sepsis, febrile neutropenia, and hospital-acquired pneumonia include empiric regimens incorporating two antibiotics from different classes with activity against Pseudomonas aeruginosa for select at-risk patients to increase the likelihood of susceptibility to at least one agent.Objectives: The activity and cross-resistance rates of ceftolozane/tazobactam were compared to β-lactam comparators cefepime, ceftazidime, piperacillin/tazobactam, and meropenem alone and cumulatively with ciprofloxacin or tobramycin against P...
September 18, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28915068/prevalence-and-transmission-of-antimicrobial-resistance-in-a-vertically-integrated-veal-calf-production-system
#20
Holden Hutchinson, Sarah Finney, Lohendy Muñoz-Vargas, Sydnee Feicht, Margaret Masterson, Gregory Habing
Transmission of antimicrobial resistance (AMR) from animal production systems to humans through the food supply is a public health concern. Currently, little is known about the prevalence of AMR among veal calves in the United States. Therefore, the objective of this prospective cohort study was to estimate the prevalence of AMR and multidrug resistance (MDR) among Escherichia coli within a vertically integrated production system. In addition, this study aimed to identify genes associated with phenotypic resistance to third- and fourth-generation cephalosporins (3GC and 4GC)...
September 15, 2017: Foodborne Pathogens and Disease
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