keyword
https://read.qxmd.com/read/38468647/safety-and-timing-of-early-therapeutic-anticoagulation-therapy-after-craniotomy
#1
JOURNAL ARTICLE
John M Wilson, Kierany B Shelvin, Sarah E Lawhon, George A Crabill, Ellery A Hayden, Alan J Velander
BACKGROUND: To date, there are few guidelines and studies to guide the timing of initiation of therapeutic anticoagulation (AC) after craniotomy. The goal of this study was to assess the timing, safety, and outcomes of patients following the administration of therapeutic AC after craniotomy. METHODS: A retrospective case-control study was performed evaluating all craniotomy patients from August 2017 to July 2021. Cases were selected if they received therapeutic AC within ten days of craniotomy...
2024: Surgical Neurology International
https://read.qxmd.com/read/38452609/clingen-variant-curation-expert-panel-recommendations-for-classification-of-variants-in-gamt-gatm-and-slc6a8-for-cerebral-creatine-deficiency-syndromes
#2
JOURNAL ARTICLE
Jennifer Goldstein, Amanda Thomas-Wilson, Emily Groopman, Vimla Aggarwal, Simona Bianconi, Raquel Fernandez, Kim Hart, Nicola Longo, Nicole Liang, Daniel Reich, Heidi Wallis, Meredith Weaver, Sarah Young, Saadet Mercimek-Andrews
Cerebral creatine deficiency syndromes (CCDS) are inherited metabolic phenotypes of creatine synthesis and transport. There are two enzyme deficiencies, guanidinoacetate methyltransferase (GAMT), encoded by GAMT and arginine-glycine amidinotransferase (AGAT), encoded by GATM, which are involved in the synthesis of creatine. After synthesis, creatine is taken up by a sodium-dependent membrane bound creatine transporter (CRTR), encoded by SLC6A8, into all organs. Creatine uptake is very important especially in high energy demanding organs such as the brain, and muscle...
March 2, 2024: Molecular Genetics and Metabolism
https://read.qxmd.com/read/38436875/adult-versus-adolescent-idiopathic-scoliosis-surgery-a-meta-analysis-of-clinical-and-radiographic-outcomes
#3
REVIEW
Jeffrey W Chen, Hani Chanbour, Rishabh Gupta, Justine Izah, Wilson E Vaughan, Amir M Abtahi, Scott L Zuckerman, Byron F Stephens
INTRODUCTION: While the natural history of adolescent idiopathic scoliosis (AIS) and adult idiopathic scoliosis (AdIS) is well documented in the literature, the impact of age on postoperative outcomes remains an active area of research. We performed a systematic review and meta-analysis to compare patients undergoing surgery for AIS and AdIS with respect to: (1) postoperative Cobb correction, (2) perioperative variables, and (3) postoperative complications. METHODS: A systematic literature search was performed in accordance with preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines...
March 4, 2024: European Spine Journal
https://read.qxmd.com/read/38407117/designing-inhaled-small-molecule-drugs-for-severe-respiratory-diseases-an-overview-of-the-challenges-and-opportunities
#4
REVIEW
Cornelia H Rinderknecht, Miaoran Ning, Connie Wu, Mark S Wilson, Christian Gampe
INTRODUCTION: Inhaled drugs offer advantages for the treatment of respiratory diseases over oral drugs by delivering the drug directly to the lung, thus improving the therapeutic index. There is an unmet medical need for novel therapies for lung diseases, exacerbated by a multitude of challenges for the design of inhaled small molecule drugs. AREAS COVERED: The authors review the challenges and opportunities for the design of inhaled drugs for respiratory diseases with a focus on new target discovery, medicinal chemistry, and pharmacokinetic, pharmacodynamic, and toxicological evaluation of drug candidates...
February 26, 2024: Expert Opinion on Drug Discovery
https://read.qxmd.com/read/38382860/opportunistic-screening-for-coronary-artery-disease-an-untapped-population-health-resource
#5
REVIEW
Rubab Malik, Kristie Sun, Javad Azadi, Brandyn Lau, Seamus Whelton, Armin Zadeh, Renee Wilson, Pamela T Johnson
BACKGROUND: Coronary artery disease (CAD) is the leading cause of death in the United States. At risk asymptomatic adults are eligible for screening with EKG-gated coronary artery calcium (CAC) CT, which aids in risk stratification and management decision-making. Incidental CAC (iCAC) is easily quantified on chest CT in patients imaged for noncardiac indications; however, radiologists do not routinely report the finding. OBJECTIVE: To determine the clinical significance of CAC identified incidentally on routine chest CT performed for non-cardiac indications...
February 19, 2024: Journal of the American College of Radiology: JACR
https://read.qxmd.com/read/38374343/a-terminal-metabolite-of-niacin-promotes-vascular-inflammation-and-contributes-to-cardiovascular-disease-risk
#6
JOURNAL ARTICLE
Marc Ferrell, Zeneng Wang, James T Anderson, Xinmin S Li, Marco Witkowski, Joseph A DiDonato, James R Hilser, Jaana A Hartiala, Arash Haghikia, Tomas Cajka, Oliver Fiehn, Naseer Sangwan, Ilja Demuth, Maximilian König, Elisabeth Steinhagen-Thiessen, Ulf Landmesser, W H Wilson Tang, Hooman Allayee, Stanley L Hazen
Despite intensive preventive cardiovascular disease (CVD) efforts, substantial residual CVD risk remains even for individuals receiving all guideline-recommended interventions. Niacin is an essential micronutrient fortified in food staples, but its role in CVD is not well understood. In this study, untargeted metabolomics analysis of fasting plasma from stable cardiac patients in a prospective discovery cohort (n = 1,162 total, n = 422 females) suggested that niacin metabolism was associated with incident major adverse cardiovascular events (MACE)...
February 19, 2024: Nature Medicine
https://read.qxmd.com/read/38373851/long-term-cardiovascular-risks-and-the-impact-of-statin-treatment-on-socioeconomic-inequalities-a-microsimulation-model
#7
JOURNAL ARTICLE
Runguo Wu, Claire Williams, Junwen Zhou, Iryna Schlackow, Jonathan Emberson, Christina Reith, Anthony Keech, John Robson, Jane Armitage, Alastair Gray, John Simes, Colin Baigent, Borislava Mihaylova, Jane Armitage, Colin Baigent, Elizabeth Barnes, Lisa Blackwell, Rory Collins, Kelly Davies, Jonathan Emberson, Jordan Fulcher, Heather Halls, William G Herrington, Lisa Holland, Anthony Keech, Adrienne Kirby, Borislava Mihaylova, Rachel O'Connell, David Preiss, Christina Reith, John Simes, Kate Wilson, Michael Blazing, Eugene Braunwald, James de Lemos, Sabina Murphy, Terje R Pedersen, Marc Pfeffer, Harvey White, Stephen Wiviott, Michael Clearfield, John R Downs, Antonio Gotto, Stephen Weis, Bengt Fellström, Hallvard Holdaas, Alan Jardine, Terje R Pedersen, David Gordon, Barry Davis, Curt Furberg, Richard Grimm, Sara Pressel, Jeffrey L Probstfield, Mahboob Rahman, Lara Simpson, Michael Koren, Björn Dahlöf, Ajay Gupta, Neil Poulter, Peter Sever, Hans Wedel, Robert H Knopp, Stuart Cobbe, Bengt Fellström, Hallvard Holdaas, Alan Jardine, Roland Schmieder, Faiez Zannad, D John Betteridge, Helen M Colhoun, Paul N Durrington, John Fuller, Graham A Hitman, Andrew Neil, Eugene Braunwald, Barry Davis, C Morton Hawkins, Lemuel Moyé, Marc Pfeffer, Frank Sacks, John Kjekshus, Hans Wedel, John Wikstrand, Christoph Wanner, Vera Krane, Maria Grazia Franzosi, Roberto Latini, Donata Lucci, Aldo Maggioni, Roberto Marchioli, Enrico B Nicolis, Luigi Tavazzi, Gianni Tognoni, Jackie Bosch, Eva Lonn, Salim Yusuf, Jane Armitage, Louise Bowman, Rory Collins, Anthony Keech, Martin Landray, Sarah Parish, Richard Peto, Peter Sleight, John Jp Kastelein, Terje R Pedersen, Robert Glynn, Antonio Gotto, John Jp Kastelein, Wolfgang Koenig, Jean MacFadyen, Paul M Ridker, Anthony Keech, Stephen MacMahon, Ian Marschner, Andrew Tonkin, John Shaw, John Simes, Harvey White, Patrick W Serruys, Genell Knatterud, Gerard J Blauw, Stuart Cobbe, Ian Ford, Peter Macfarlane, Chris Packard, Naveed Sattar, James Shepherd, Stella Trompet, Eugene Braunwald, Christopher P Cannon, Sabina Murphy, Rory Collins, Jane Armitage, Louise Bowman, Richard Bulbulia, Richard Haynes, Sarah Parish, Richard Peto, Peter Sleight, Pierre Amarenco, K Michael Welch, John Kjekshus, Terje R Pedersen, Lars Wilhelmsen, Philip Barter, Antonio Gotto, John LaRosa, John Jp Kastelein, James Shepherd, Stuart Cobbe, Ian Ford, Sharon Kean, Peter Macfarlane, Chris Packard, Michele Roberston, Naveed Sattar, James Shepherd, Robin Young, Hiroyuki Arashi, Robert Clarke, Marcus Flather, Shinya Goto, Uri Goldbourt, Jemma Hopewell, G Kees Hovingh, George Kitas, Connie Newman, Marc S Sabatine, Gregory G Schwartz, Liam Smeeth, Jonathan Tobert, John Varigos, Junichi Yamamguchi
BACKGROUND: UK cardiovascular disease (CVD) incidence and mortality have declined in recent decades but socioeconomic inequalities persist. AIM: To present a new CVD model, and project health outcomes and the impact of guideline-recommended statin treatment across quintiles of socioeconomic deprivation in the UK. DESIGN AND SETTING: A lifetime microsimulation model was developed using 117 896 participants in 16 statin trials, 501 854 UK Biobank (UKB) participants, and quality-of-life data from national health surveys...
February 19, 2024: British Journal of General Practice
https://read.qxmd.com/read/38343604/case-presentation-functional-assessment-of-a-casr-variant-identified-in-a-patient-with-hypercalcaemia-confirms-familial-hypocalciuric-hypercalcaemia-in-the-patient-and-a-sister-previously-misdiagnosed-with-primary-hyperparathyroidism
#8
Bryan K Ward, Kirsten A Loffell, John P Walsh, Warwick D Howe, Suzanne J Brown, Scott G Wilson
BACKGROUND: Primary hyperparathyroidism (PHPT) and familial hypocalciuric hypercalcaemia (FHH) are common causes of hypercalcaemia. Patients are mostly asymptomatic in the case of FHH and often so in the case of PHPT. In addition, biochemical parameters show considerable overlap, making differential diagnosis difficult. Genetic screening for inactivating variants in the calcium-sensing receptor ( CASR ) gene that are causative of FHH assists with the diagnosis since such variants are not generally associated with PHPT...
2024: Case Reports in Endocrinology
https://read.qxmd.com/read/38342438/who-s-essential-medicines-and-aware-recommendations-on-first-and-second-choice-antibiotics-for-empiric-treatment-of-clinical-infections
#9
JOURNAL ARTICLE
Lorenzo Moja, Veronica Zanichelli, Dominik Mertz, Sumanth Gandra, Bernadette Cappello, Graham S Cooke, Pem Chuki, Stephan Harbarth, Celine Pulcini, Marc Mendelson, Evelina Tacconelli, Loice Achieng Ombajo, Ronald Chitatanga, Mei Zeng, Monica Imi, Christelle Elias, Per Ashorn, Annamaria Marata, Sarah Paulin, Arno Muller, Awa Aidara-Kane, Teodora Elvira Wi, Wilson Milton Were, Elizabeth Tayler, Albert Figueras, Carmem Pessoa Da Silva, Catharina Van Weezenbeek, Nicola Magrini, Mike Sharland, Benedikt Huttner, Mark Loeb
The WHO Model List of Essential Medicines (EML) prioritizes medicines that have significant global public health value. The EML can also deliver important messages on appropriate medicine use. Since 2017, in response to the growing challenge of antimicrobial resistance, antibiotics on the EML were reviewed and categorized into three groups: Access, Watch and Reserve, leading to a new categorization called AWaRe. These categories were developed taking into account the impact of different antibiotics and classes on antimicrobial resistance, and the implications for their appropriate use...
February 9, 2024: Clinical Microbiology and Infection
https://read.qxmd.com/read/38331381/design-of-a-pragmatic-randomized-implementation-effectiveness-trial-testing-a-health-system-wide-hypertension-program-for-older-adults
#10
RANDOMIZED CONTROLLED TRIAL
Aditi Gupta, Hira Chouhdry, Shellie D Ellis, Kate Young, Jonathan Mahnken, Branden Comfort, Denton Shanks, Sheila McGreevy, Courtney Rudy, Tahira Zufer, Sharissa Mabry, Jennifer Woodward, Amber Wilson, Heidi Anderson, Jennifer Loucks, Sravani Chandaka, Noor Abu-El-Rub, Diego R Mazzotti, Xing Song, Nolan Schmitz, Molly Conroy, Mark A Supiano, Lemuel R Waitman, Jeffrey M Burns
Hypertension control remains poor. Multiple barriers at the level of patients, providers, and health systems interfere with implementation of hypertension guidelines and effective lowering of BP. Some strategies such as self-measured blood pressure (SMBP) and remote management by pharmacists are safe and effectively lower BP but have not been effectively implemented. In this study, we combine such evidence-based strategies to build a remote hypertension program and test its effectiveness and implementation in large health systems...
March 2024: Contemporary Clinical Trials
https://read.qxmd.com/read/38310346/magnetic-resonance-imaging-guided-frameless-stereotactic-injections-of-the-bilateral-cerebellar-dentate-nuclei-in-nonhuman-primates-technical-note
#11
JOURNAL ARTICLE
Liming Qiu, Emily Xu, Sydney Chambule, Philip LaTourette, Cecilia D Dyer, Chelsea K Wallace, Rachel Donocoff, James M Wilson, Timothy H Lucas, H Isaac Chen
BACKGROUND AND OBJECTIVES: Nonhuman primates (NHPs) are important preclinical models for evaluating therapeutics because of their anatomophysiological similarities to humans, and can be especially useful for testing new delivery targets. With the growing promise of cell and gene therapies for the treatment of neurological diseases, it is important to ensure the accurate and safe delivery of these agents to target structures in the brain. However, a standard guideline or method has not been developed for stereotactic targeting in NHPs...
February 1, 2024: Operative Neurosurgery (Hagerstown, Md.)
https://read.qxmd.com/read/38299485/mucinous-ovarian-carcinoma-a-survey-of-practice-in-australia-and-new-zealand
#12
JOURNAL ARTICLE
Niveditha Rajadevan, Ariane Flinkier, Hugo Saunders, Yeh Chen Lee, Clare Scott, Pearly Khaw, Prue Allan, Claire Davies, John Andrews, Michelle Wilson, Janine M Lombard, Michelle Harrison, Heshani Nesfield, Anna DeFazio, Tarek Meniawy, Kylie L Gorringe
BACKGROUND: Mucinous ovarian carcinoma (MOC) is a rare ovarian cancer with limited evidence to support clinical care. AIMS: We undertook a clinician survey to better understand current practice in treating MOC in Australia and New Zealand, and to determine any features associated with variation in care. In addition, we aimed to understand future research priorities. METHODS: A RedCap survey was distributed to clinician members of the Australia New Zealand Gynaecological Oncology Group (ANZGOG)...
February 1, 2024: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://read.qxmd.com/read/38296587/thrombolysis-for-ischaemic-stroke-despite-direct-oral-anticoagulation
#13
EDITORIAL
Jan C Purrucker, Thomas R Meinel, Duncan Wilson, Ying Xian, Teddy Y Wu, David J Seiffge
Intravenous thrombolysis is not recommended in anticoagulated patients receiving direct oral anticoagulants (DOACs) and a recent intake within the last 48 hours in US and European guidelines. However, three observational studies now suggest safety of thrombolysis in patients with recent intake of DOACs, and thus support previous experimental data. In this perspective, the current evidence and practical consequences are discussed.
January 31, 2024: Stroke and Vascular Neurology
https://read.qxmd.com/read/38293408/hiv-related-knowledge-attitude-practices-and-stigma-among-healthcare-providers-caring-for-hiv-in-jordan-identification-of-several-organizational-challenges
#14
JOURNAL ARTICLE
Randa K Saad, Yousef Khader, Ashraf Jamil Aqel, Srinath Satyanarayana, Nevin Wilson, Hiba Abaza
BACKGROUND: There is a paucity of data on Healthcare Providers (HCPs) caring for people living with HIV in Jordan. OBJECTIVE: We aimed to understand HCPs' knowledge, attitude, stigma, and practices, to assess the gaps in HIV care in Jordan. METHODS: We conducted recorded in-depth interviews with all five HCPs working at the only HIV Service Center in Jordan, using semi-structured questions in 2021. Content analysis was performed. RESULTS: Several organizational challenges were identified...
January 30, 2024: Heliyon
https://read.qxmd.com/read/38273720/nsaid-use-in-orthopedic-surgery-%C3%A2-a-review-of-current-evidence-and-clinical-practice-guidelines
#15
REVIEW
Patrick M Ryan, Haydn Scherry, Ryan Pierson, Charlie Dee Wilson, Robert A Probe
Nonsteroidal anti-inflammatory drugs (NSAIDs) are a valuable class of medications for orthopedic surgeons and often play a pivotal role in pain control. However, there are many common stipulations resulting in avoidance of its use in the treatment of musculoskeletal disease. This review summarizes the mechanism of action of NSAIDs as well as provides an overview of commonly used NSAIDs and the differences between them. It provides a concise summary on the osseous effects of NSAIDs with regard to bone healing and heterotopic ossification...
January 25, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/38270708/the-use-of-biofluid-markers-to-evaluate-the-consequences-of-sport-related-subconcussive-head-impact-exposure-a-scoping-review
#16
Liivia-Mari Lember, Michail Ntikas, Stefania Mondello, Lindsay Wilson, Thomas G Di Virgilio, Angus M Hunter, Firas Kobeissy, Yehia Mechref, David I Donaldson, Magdalena Ietswaart
BACKGROUND: Amidst growing concern about the safety of sport-related repetitive subconcussive head impacts (RSHI), biofluid markers may provide sensitive, informative, and practical assessment of the effects of RSHI exposure. OBJECTIVE: This scoping review aimed to systematically examine the extent, nature, and quality of available evidence from studies investigating the effects of RSHI on biofluid markers, to identify gaps and to formulate guidelines to inform future research...
January 25, 2024: Sports Medicine—Open
https://read.qxmd.com/read/38248856/metabolomic-signatures-of-brainstem-in-mice-following-acute-and-subchronic-hydrogen-sulfide-exposure
#17
JOURNAL ARTICLE
Dong-Suk Kim, Cristina M Santana Maldonado, Cecilia Giulivi, Wilson Kiiza Rumbeiha
Hydrogen sulfide (H2 S) is an environmental toxicant of significant health concern. The brain is a major target in acute H2 S poisoning. This study was conducted to test the hypothesis that acute and subchronic ambient H2 S exposures alter the brain metabolome. Male 7-8-week-old C57BL/6J mice were exposed by whole-body inhalation to 1000 ppm H2 S for 45 min and euthanized at 5 min or 72 h for acute exposure. For subchronic study, mice were exposed to 5 ppm H2 S 2 h/day, 5 days/week for 5 weeks. Control mice were exposed to room air...
January 14, 2024: Metabolites
https://read.qxmd.com/read/38244577/the-non-to-moderately-dilated-root-in-acute-type-a-aortic-dissection-outcomes-of-the-penn-bern-registry-in-young-non-syndromic-patients
#18
JOURNAL ARTICLE
Selim Mosbahi, Matthias R Siepe, Nimesh D Desai, Fabio Pregaldini, Maria Nucera, M Berezowski, John J Kelly, Fei Jiang, Yu Zhao, Wilson Y Szeto, Florian S Schoenhoff, Joseph E Bavaria
OBJECTIVES: There is an ongoing debate regarding whether patients benefit more from root replacement compared to a reconstruction of the sinuses of Valsalva in acute type A aortic dissection. In those with known or suspected connective tissue disorders, root replacement is considered appropriate. However, there are currently no diameter-based guidelines regarding the best approach in patients with minimally to moderately dilated root and no connective tissue disorders. METHODS: From January 2005 to December 2022, a two-center registry of acute type A aortic dissection was created...
January 19, 2024: European Journal of Cardio-thoracic Surgery
https://read.qxmd.com/read/38237723/comparison-of-hotv-optotypes-and-lea-symbols-a-systematic-review-and-meta-analysis
#19
JOURNAL ARTICLE
Elizabeth G Van Swol, Annika Gupta, Shaun A Nguyen, M Edward Wilson
PURPOSE: To report the findings of our systematic review and meta-analysis comparing the completion time and testing timeof visual acuity testing using Lea Symbols or HOTV optotypes. METHODS: A systematic search of PubMed, SCOPUS, and CINAHL was conducted according to the PRISMA guidelines. RESULTS: The completion rate for HOTV optotypes and Lea Symbols visual acuity testing was reported for 7,948 patients (average age, 3.59 years; age range, 2-17; 49...
January 16, 2024: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://read.qxmd.com/read/38199907/first-line-palliative-chemotherapy-for-colorectal-cancer-a-population-based-analysis-of-delivery-and-outcomes-in-a-single-payer-health-system
#20
JOURNAL ARTICLE
B E Wilson, C M Booth, S Patel, S Berry, W Kong, S J Merchant
AIMS: Clinical practice guidelines recommend palliative chemotherapy for most patients with metastatic colorectal cancer. However, outcomes observed in the real world compared with patients enrolled in clinical trials have not been sufficiently described. The objective of this study was to evaluate the delivery and outcomes of first-line palliative chemotherapy administered to patients with colorectal cancer in routine clinical practice compared with clinical trials. MATERIALS AND METHODS: Using linked health administrative data, we carried out a retrospective population-level cohort study on patients diagnosed with colorectal cancer in Ontario, Canada from 2010 to 2019...
December 13, 2023: Clinical Oncology: a Journal of the Royal College of Radiologists
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