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https://www.readbyqxmd.com/read/29330214/statins-have-a-dose-dependent-effect-on-amputation-and-survival-in-peripheral-artery-disease-patients
#1
Shipra Arya, Anjali Khakharia, Zachary O Binney, Randall R DeMartino, Luke P Brewster, Philip P Goodney, Peter W F Wilson
Background -Statin dose guidelines for Peripheral Artery Disease (PAD) patients are largely based on coronary artery disease and stroke data. The aim of this study is to determine the effect of statin intensity on PAD outcomes of amputation and mortality. Methods -Using an observational cohort study design and a validated algorithm we identified incident PAD patients (2003-2014) in the national Veterans Affairs data. Highest statin intensity exposure [high intensity vs low- moderate intensity vs antiplatelet therapy but no statin use (AP only)] was determined within one year of diagnosis of PAD...
January 12, 2018: Circulation
https://www.readbyqxmd.com/read/29329395/open-access-physical-activity-programs-for-older-adults-a-pragmatic-and-systematic-review
#2
Laura E Balis, Thomas Strayer, NithyaPriya Ramalingam, Meghan Wilson, Samantha M Harden
Background and Objectives: Open-access, community-based programs are recommended to assist older adults in meeting physical activity guidelines, but the characteristics, impact, and scalability of these programs is less understood. The Land-Grant University Cooperative Extension System, an organization providing education through county-based educators, functions as a delivery system for these programs. A systematic review was conducted to determine characteristics of effective older adult physical activity programs and the extent to which programs delivered in Extension employ these characteristics...
January 10, 2018: Gerontologist
https://www.readbyqxmd.com/read/29313458/clinician-perspectives-on-strategies-to-improve-patient-maternal-immunization-acceptability-in-obstetrics-and-gynecology-practice-settings
#3
Paula M Frew, Laura A Randall, Fauzia Malik, Rupali Lamaye, Andrew Wilson, Sean T O'Leary, Daniel Salmon, Meghan Donnelly, Kevin Ault, Matthew Z Dudley, Vincent L Fenimore, Saad B Omer
Pregnancy is an ideal time to communicate with women about vaccines for themselves and their infants, yet maternal immunization rates remain suboptimal. This study aimed to identify clinic, provider, and staff-related attributes and facilitators to be utilized for a comprehensive vaccine intervention in ob-gyn clinical settings. We conducted in-depth interviews with 24 providers, both healthcare providers (e.g., physicians, nurse practitioners, midwives) and practice managers, from urban and suburban ob-gyn practices in Georgia and Colorado about their immunization attitudes, practices, and patient experiences...
January 9, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29310636/sociodemographic-correlates-of-urine-culture-test-utilization-in-calgary-alberta
#4
Thomas P Griener, Christopher Naugler, Wilson W Chan, Deirdre L Church
BACKGROUND: Many clinical practice guidelines encourage diagnosis and empiric treatment of lower urinary tract infection without laboratory investigation; however, urine culture testing remains one of the largest volume tests in the clinical microbiology laboratory. In this study, we sought to determine if there were specific patient groups to which increased testing was directed. To do so, we combined laboratory data on testing rates with Census Canada sociodemographic data. METHODS: Urine culture testing data was obtained from the Calgary Laboratory Services information system for 2011...
January 8, 2018: BMC Urology
https://www.readbyqxmd.com/read/29305313/effectiveness-of-the-gocheck-kids-vision-screener-in-detecting-amblyopia-risk-factors
#5
M Millicent W Peterseim, Ryan S Rhodes, Rupa N Patel, M Edward Wilson, Luke E Edmondson, Sarah A Logan, Edward W Cheeseman, Emily Shortridge, Rupal H Trivedi
Effectiveness of the GoCheck Kids Vision Screener in Detecting Amblyopia Risk Factors, MMW Peterseim, RS Rhodes, RN Patel, ME Wilson, LE Edmondson, SA Logan, EW Cheeseman, E Shortridge, RH Trivedi. INTRODUCTION: The GoCheck Kids smartphone photoscreening app (Gobiquity Mobile Health, Scottsdale, Arizona), introduced in 2014, is marketed to pediatricians with little published validation. We wished to evaluate the GoCheck Kids Screener for accuracy in detecting amblyopia risk factors (ARF) using 2013 AAPOS guidelines...
January 2, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29289910/chemical-extraction-of-trace-elements-from-hazardous-fine-fraction-at-an-old-glasswork-dump
#6
Yahya Jani, William Hogland
Old glassworks sites have been always associated with contamination by different trace elements like Pb, Cd, As, Zn and others. The mixture of soil and waste glass of particle sizes <2 mm at one of the oldest Swedish glassworks (the Pukeberg) was studied by analyzing the trace elements content, organic content (3.6%) and pH (7.4). The results showed hazardous concentrations of Pb (1525 mg/kg), Ba (1312 mg/kg), Sb (128 mg/kg), Cd (36 mg/kg), As (118 mg/kg), Zn (1154 mg/kg) and Co (263 mg/kg) exceeded the Swedish guidelines of contaminated soil...
December 26, 2017: Chemosphere
https://www.readbyqxmd.com/read/29288860/association-between-idh1-2-mutation-and-preoperative-seizures-in-patients-with-low-grade-versus-high-grade-glioma-a-systematic-review-and-meta-analysis
#7
Kevin Phan, Wyatt Ng, Victor M Lu, Kerrie L McDonald, Jacob Fairhall, Rajesh Reddy, Peter Wilson
BACKGROUND: Seizures are a common presentation of brain tumors particularly in gliomas. Higher incidences of seizure have been reported in low-grade glioma and tumors located within the temporal and insular area. The association between IDH1/2 mutations with preoperative seizures in glioma and the magnitude of this association in low versus high-grade gliomas remains unclear. To clarify this relationship, a systematic review and meta-analysis was performed. METHOD: Following the PRISMA guidelines and systematic review recommendations, electronic searches were performed on varies journal database and included literature up to May 2017...
December 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29282109/simulated-patient-encounters-to-improve-adolescent-retention-in-hiv-care-in-kenya-study-protocol-of-a-stepped-wedge-randomized-controlled-trial
#8
Kate S Wilson, Cyrus Mugo, David Bukusi, Irene Inwani, Anjuli D Wagner, Helen Moraa, Tamara Owens, Joseph B Babigumira, Barbra A Richardson, Grace C John-Stewart, Jennifer A Slyker, Dalton C Wamalwa, Pamela K Kohler
BACKGROUND: Adolescent-friendly policies aim to tailor HIV services for adolescents and young adults aged 10-24 years (AYA) to promote health outcomes and improve retention in HIV care and treatment. However, few interventions focus on improving healthcare worker (HCW) competencies and skills for provision of high-quality adolescent care. Standardized patients (SPs) are trained actors who work with HCWs in mock clinical encounters to improve clinical assessment, communication, and empathy skills...
December 28, 2017: Trials
https://www.readbyqxmd.com/read/29260485/managing-variant-interpretation-discrepancies-in-hereditary-cancer-clinical-practice-concerns-and-desired-resources
#9
Ellen Zirkelbach, Syed Hashmi, Aarti Ramdaney, Leslie Dunnington, Myla Ashfaq, Elizabeth K Nugent, Kate Wilson
Variant interpretation is a complex process, and classification may vary between sources. This study aimed to determine the practice of cancer genetic counselors regarding discrepancies in variant interpretation and to identify concerns when counseling these discrepancies. An electronic survey was sent to genetic counselors in the NSGC Cancer Special Interest Group. The vast majority of counselors (93%) had seen a variant interpretation discrepancy in practice. A large majority (96%) of respondents indicated that they conducted their own research on reported variants...
December 20, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29247143/cognitive-impairment-before-intracerebral-hemorrhage-is-associated-with-cerebral-amyloid-angiopathy
#10
Gargi Banerjee, Duncan Wilson, Gareth Ambler, Karen Osei-Bonsu Appiah, Clare Shakeshaft, Surabhika Lunawat, Hannah Cohen, Tarek Yousry, Gregory Y H Lip, Keith W Muir, Martin M Brown, Rustam Al-Shahi Salman, Hans Rolf Jäger, David J Werring
BACKGROUND AND PURPOSE: Although the association between cerebral amyloid angiopathy (CAA) and cognitive impairment is increasingly recognized, it is not clear whether this is because of the impact of recurrent intracerebral hemorrhage (ICH) events, disruptions caused by cerebral small vessel damage, or both. We investigated this by considering whether cognitive impairment before ICH was associated with neuroimaging features of CAA on magnetic resonance imaging. METHODS: We studied 166 patients with neuroimaging-confirmed ICH recruited to a prospective multicentre observational study...
December 15, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29241775/retrospective-effects-of-the-american-joint-committee-on-cancer-s-eighth-edition-guidelines-for-staging-melanoma
#11
Janice M Wilson, Eduardo Rodriguez, Brent C Kelly
No abstract text is available yet for this article.
January 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29223750/choosing-pre-conception-planning-for-women-families-counselling-and-informed-consent-part-2-pre-conception-reproductive-planning-lifestyle-immunization-and-psychosocial-issues
#12
REVIEW
R Douglas Wilson
OBJECTIVE: To inform reproductive and other health care providers about pre-conception evaluation, including considerations for reproductive planning, lifestyle modification, immunization status and attitudes, and psychosocial issues. OPTIONS: This counselling information can be used for patient education and planning and possible pre-conception and/or prenatal testing. OUTCOMES: This information may allow for improved risk assessment when pre-conception counselling for individual patients and their families is used...
December 6, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29215970/energy-expenditure-in-professional-flat-jockeys-using-doubly-labelled-water-during-the-racing-season-implications-for-body-weight-management
#13
George Wilson, Daloni Lucas, Catherine Hambly, John R Speakman, James P Morton, Graeme L Close
To formulate individualized dietary strategies for jockeys, it is vital that energy requirements are quantified. We measured total energy expenditure (TEE) over two separate weeks in spring and summer using doubly labelled water in a group of male flat jockeys (n = 8, 36.9 ± 5.7 years, 164 ± 8 cm, 54.6 ± 2.5 kg). Total energy intake (TEI) was self-recorded, as were all riding and structured exercise activity. Mean daily TEE was 10.83 (±2.3) and 10.66 (±1.76) MJ, (p = .61) respectively...
December 7, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/29196247/early-and-late-post-traumatic-epilepsy-in-the-setting-of-traumatic-brain-injury-a-review-of-anti-epileptic-management
#14
Christopher D Wilson, Josh D Burks, Richard B Rodgers, Robert M Evans, Adewale A Bakare, Sam Safavi-Abbasi
INTRODUCTION: Moderate to severe traumatic brain injury confers increased risk of early and late post-traumatic seizures (PTS). Early PTS are diagnosed when seizures develop within 7 days following injury, whereas initial seizures in late PTS occur later. Traditionally, patients have been treated with phenytoin (PHT) to prevent early PTS, and more recently with levetiracetam (LEV). Various regimens have been tried in patients to prevent late PTS with variable success. In this meta-analysis, we assessed and compared effectiveness of these drugs on early and late PTS prevention...
November 28, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29174187/risk-of-cancer-death-by-comorbidity-severity-and-use-of-adjuvant-chemotherapy-among-women-with-locoregional-breast-cancer
#15
Gretchen G Kimmick, Xiangrong Li, Steven T Fleming, Susan A Sabatino, J Frank Wilson, Joseph Lipscomb, Rosemary Cress, Carmen Bergom, Roger T Anderson, Xiao-Cheng Wu
OBJECTIVES: To examine the associations of comorbidity and chemotherapy with breast cancer- and non-breast cancer-related death. MATERIALS AND METHODS: Included were women with invasive locoregional breast cancer diagnosed in 2004 from seven population-based cancer registries. Data were abstracted from medical records and verified with treating physicians when there were inconsistencies and missing information on cancer treatment. Comorbidity severity was quantified using the Adult Comorbidity Evaluation 27...
November 22, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29168303/fall-risk-assessment-tools-for-use-among-older-adults-in-long-term-care-settings-a-systematic-review-of-the-literature
#16
REVIEW
Susan Nunan, Christine Brown Wilson, Timothy Henwood, Deborah Parker
OBJECTIVE: To conduct a systematic review of published fall risk assessment tools (FRATs) tested for predictive validity among older adults in long-term care (LTC). METHODS: A systematic search was conducted using five databases. Only studies reporting on sensitivity and specificity values, conducted in LTC on populations primarily aged over 60 years, were considered. RESULTS: Fifteen papers were included and three different categories of FRATs emerged: multifactorial assessment tools, functional mobility assessments and algorithms...
November 23, 2017: Australasian Journal on Ageing
https://www.readbyqxmd.com/read/29164037/guidelines-for-the-management-of-degenerative-cervical-myelopathy-and-acute-spinal-cord-injury-development-process-and-methodology
#17
Lindsay A Tetreault, Andrea C Skelly, Joseph R Dettori, Jefferson R Wilson, Allan R Martin, Michael G Fehlings
The Institute of Medicine defines clinical practice guidelines as "statements that include recommendations intended to optimize patient care that are informed by a systematic review of evidence and an assessment of the benefits and harms of alternative care options." Guidelines help clinicians implement best evidence into practice and encourage informed shared decision making with patients. Guidelines are intended to enhance the quality of patient care by discouraging ineffective and potentially harmful interventions and standardizing practice...
September 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29164036/a-clinical-practice-guideline-for-the-management-of-acute-spinal-cord-injury-introduction-rationale-and-scope
#18
Michael G Fehlings, Lindsay A Tetreault, Jefferson R Wilson, Brian K Kwon, Anthony S Burns, Allan R Martin, Gregory Hawryluk, James S Harrop
Acute spinal cord injury (SCI) is a traumatic event that results in disturbances to normal sensory, motor, or autonomic function and ultimately affects a patient's physical, psychological, and social well-being. The management of patients with SCI has drastically evolved over the past century as a result of increasing knowledge on injury mechanisms, disease pathophysiology, and the role of surgery. There still, however, remain controversial areas surrounding available management strategies for the treatment of SCI, including the use of corticosteroids such as methylprednisolone sodium succinate, the optimal timing of surgical intervention, the type and timing of anticoagulation prophylaxis, the role of magnetic resonance imaging, and the type and timing of rehabilitation...
September 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29164035/a-clinical-practice-guideline-for-the-management-of-patients-with-degenerative-cervical-myelopathy-recommendations-for-patients-with-mild-moderate-and-severe-disease-and-nonmyelopathic-patients-with-evidence-of-cord-compression
#19
Michael G Fehlings, Lindsay A Tetreault, K Daniel Riew, James W Middleton, Bizhan Aarabi, Paul M Arnold, Darrel S Brodke, Anthony S Burns, Simon Carette, Robert Chen, Kazuhiro Chiba, Joseph R Dettori, Julio C Furlan, James S Harrop, Langston T Holly, Sukhvinder Kalsi-Ryan, Mark Kotter, Brian K Kwon, Allan R Martin, James Milligan, Hiroaki Nakashima, Narihito Nagoshi, John Rhee, Anoushka Singh, Andrea C Skelly, Sumeet Sodhi, Jefferson R Wilson, Albert Yee, Jeffrey C Wang
Study Design: Guideline development. Objectives: The objective of this study is to develop guidelines that outline how to best manage (1) patients with mild, moderate, and severe myelopathy and (2) nonmyelopathic patients with evidence of cord compression with or without clinical symptoms of radiculopathy. Methods: Five systematic reviews of the literature were conducted to synthesize evidence on disease natural history; risk factors of disease progression; the efficacy, effectiveness, and safety of nonoperative and surgical management; the impact of preoperative duration of symptoms and myelopathy severity on treatment outcomes; and the frequency, timing, and predictors of symptom development...
September 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29164033/change-in-functional-impairment-disability-and-quality-of-life-following-operative-treatment-for-degenerative-cervical-myelopathy-a-systematic-review-and-meta-analysis
#20
REVIEW
Michael G Fehlings, Lindsay A Tetreault, Shekar Kurpad, Darrel S Brodke, Jefferson R Wilson, Justin S Smith, Paul M Arnold, Erika D Brodt, Joseph R Dettori
Study Design: Systematic review. Objectives: The primary objective of this systematic review was to define the change in impairment, disability, and pain following surgical intervention in patients with degenerative cervical myelopathy (DCM). Secondary objectives included to assess the impact of preoperative disease severity and duration of symptoms on outcomes and to summarize complications associated with surgery. Methods: A systematic literature search was conducted to identify prospective studies evaluating the effectiveness and safety of operative treatment in patients with DCM...
September 2017: Global Spine Journal
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