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https://www.readbyqxmd.com/read/28814664/pulmonary-arterial-hypertension-treatment-with-carvedilol-for-heart-failure-a-randomized-controlled-trial
#1
Samar Farha, Didem Saygin, Margaret M Park, Hoi I Cheong, Kewal Asosingh, Suzy Aa Comhair, Olivia R Stephens, Emir C Roach, Jacqueline Sharp, Kristin B Highland, Frank P DiFilippo, Donald R Neumann, W H Wilson Tang, Serpil C Erzurum
BACKGROUND: Right-sided heart failure is the leading cause of death in pulmonary arterial hypertension (PAH). Similar to left heart failure, sympathetic overactivation and β-adrenoreceptor (βAR) abnormalities are found in PAH. Based on successful therapy of left heart failure with β-blockade, the safety and benefits of the nonselective β-blocker/vasodilator carvedilol were evaluated in PAH. METHODS: PAH Treatment with Carvedilol for Heart Failure (PAHTCH) is a single-center, double-blind, randomized, controlled trial...
August 17, 2017: JCI Insight
https://www.readbyqxmd.com/read/28814218/diagnosis-and-management-of-pancreatic-exocrine-insufficiency
#2
Mehrdad Nikfarjam, Jeremy S Wilson, Ross C Smith
In 2015, the Australasian Pancreatic Club (APC) published the Australasian guidelines for the management of pancreatic exocrine insufficiency (http://pancreas.org.au/2016/01/pancreatic-exocrine-insufficiency-guidelines). Pancreatic exocrine insufficiency (PEI) occurs when normal digestion cannot be sustained due to insufficient pancreatic digestive enzyme activity. This may be related to a breakdown, at any point, in the pancreatic digestive chain: pancreatic stimulation; synthesis, release or transportation of pancreatic enzymes; or synchronisation of secretions to mix with ingested food...
August 21, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28805953/factors-associated-with-physical-activity-among-adolescent-and-young-adult-survivors-of-early-childhood-cancer-a-report-from-the-childhood-cancer-survivor-study-ccss
#3
Katie A Devine, Ann C Mertens, John A Whitton, Carmen L Wilson, Kirsten K Ness, Jordan Gilleland Marchak, Wendy Leisenring, Kevin C Oeffinger, Leslie L Robison, Gregory T Armstrong, Kevin R Krull
OBJECTIVE: To evaluate concurrent and longitudinal associations between psychosocial functioning and physical activity in adolescent and young adult survivors of early childhood cancer. METHODS: Adolescent survivors of early childhood cancer (diagnosed before age four) participating in the Childhood Cancer Survivor Study completed the Coping Health and Illness Profile-Adolescent Edition (CHIP-AE; n=303; mean age at survey 17.6 years). A subset of these survivors (n=248) completed a follow-up survey an average of 6...
August 14, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28792628/a-review-of-international-clinical-practice-guidelines-for-the-use-of-oxygen-in-the-delivery-room-resuscitation-of-preterm-infants
#4
A Wilson, M Vento, P Shah, O Saugstad, N Finer, W Rich, R Morton, Y Rabi, W Tarnow-Mordi, K Suzuki, I M Wright, J Oei
AIM: To collate and assess international clinical practice guidelines (CPG) to determine current recommendations guiding oxygen management for respiratory stablisation of preterm infants at delivery. METHODS: A search of public databases using the terms "clinical practice guidelines", "preterm", "oxygen" and "resuscitation" was made and complemented by direct query to consensus groups, resuscitation expert committees and clinicians. Data were extracted to include the three criteria for assessment: country of origin, gestation and initial FiO2 and target SpO2 for the first 10 minutes of life...
August 9, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28778037/comparison-of-midwife-led-care-and-obstetrician-led-care-on-maternal-and-neonatal-outcomes-in-singapore-a-retrospective-cohort-study
#5
Shi Tian Voon, Julie Tay Suan Lay, Wilson Tam Wai San, Shefaly Shorey, Serena Koh Siew Lin
OBJECTIVES: to examine the maternal and neonatal outcomes of low-risk women receiving midwife-led care and obstetrician-led care. DESIGN, SETTING,&PARTICIPANTS: a retrospective cohort study design was used. Data were collected from a large tertiary maternity hospital in Singapore. This involved a medical record review of 368 women who had singleton, normal to low-risk, term pregnancy, and received midwife-led care and obstetrician-led care between 2013 to 2014. MEASUREMENTS: a data extraction tool was used to solicit information on the outcome measures, including duration of labour, mode of delivery, episiotomy, and 5-minutes Apgar score (<7)...
July 18, 2017: Midwifery
https://www.readbyqxmd.com/read/28763269/summary-for-clinicians-mechanical-ventilation-in-adult-patients-with-acute-respiratory-distress-syndrome-clinical-practice-guideline
#6
Curtis H Weiss, Jakob I McSparron, Rohini S Chatterjee, Derrick Herman, Eddy Fan, Kevin C Wilson, Carey C Thomson
No abstract text is available yet for this article.
August 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28762862/a-clinician-s-guide-to-adhd-treatment-options
#7
Gregory W Mattingly, Joshua Wilson, Anthony L Rostain
Attention deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental condition of children and adolescents that often persists into adulthood. Primary care physicians are commonly the first to diagnosis ADHD and initiate a treatment plan with the patient. Guidelines recommend psychostimulant treatment as a first-line therapy in the management plan because it has a substantial impact on alleviating the core symptoms of ADHD. The recent development of a variety of methylphenidate and amphetamine formulations provides many options to meet individual patient lifestyle needs...
August 1, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28760143/decision-support-during-electronic-prescription-to-stem-antibiotic-overuse-for-acute-respiratory-infections-a-long-term-quasi-experimental-study
#8
Jeneen Gifford, Elisabeth Vaeth, Katherine Richards, Tariq Siddiqui, Christine Gill, Lucy Wilson, Sylvain DeLisle
BACKGROUND: Interventions to support decision-making can reduce inappropriate antibiotic use for acute respiratory infections (ARI), but they may not be sustainable. The objective of the study is to evaluate the long-term effectiveness of a clinical decision-support system (CDSS) interposed at the time of electronic (e-) prescriptions for selected antibiotics. METHODS: This is a retrospective, observational intervention study, conducted within a large, statewide Veterans Affairs health system...
July 31, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28746931/treatment-outcomes-for-metastatic-melanoma-of-unknown-primary-in-the-new-era-a-single-institution-study-and-review-of-the-literature
#9
Kierstin Utter, Chloe Goldman, Sarah A Weiss, Richard L Shapiro, Russell S Berman, Melissa Ann Wilson, Anna C Pavlick, Iman Osman
BACKGROUND: Metastatic melanoma of unknown primary (MUP) is uncommon, biologically ill defined, and clinically understudied. MUP outcomes are seldom reported in clinical trials. In this study, we analyze responses of MUP patients treated with systemic therapy in an attempt to inform treatment guidelines for this unique population. METHODS: New York University (NYU)'s prospective melanoma database was searched for MUP patients treated with systemic therapy. PubMed and Google Scholar were searched for MUP patients treated with immunotherapy or targeted therapy reported in the literature, and their response and survival data were compared to the MUP patient data from NYU...
July 27, 2017: Oncology
https://www.readbyqxmd.com/read/28745305/preparation-and-performance-features-of-wristband-samplers-and-considerations-for-chemical-exposure-assessment
#10
Kim A Anderson, Gary L Points, Carey E Donald, Holly M Dixon, Richard P Scott, Glenn Wilson, Lane G Tidwell, Peter D Hoffman, Julie B Herbstman, Steven G O'Connell
Wristbands are increasingly used for assessing personal chemical exposures. Unlike some exposure assessment tools, guidelines for wristbands, such as preparation, applicable chemicals, and transport and storage logistics, are lacking. We tested the wristband's capacity to capture and retain 148 chemicals including polychlorinated biphenyls (PCBs), pesticides, flame retardants, polycyclic aromatic hydrocarbons (PAHs), and volatile organic chemicals (VOCs). The chemicals span a wide range of physical-chemical properties, with log octanol-air partitioning coefficients from 2...
July 26, 2017: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/28731387/a-comparative-analysis-of-pulmonary-and-critical-care-medicine-guideline-development-methodologies
#11
Noah C Schoenberg, Alan F Barker, John Bernardo, Robin R Deterding, Jerrold J Ellner, Dean R Hess, Neil R MacIntyre, Fernando J Martinez, Kevin C Wilson
BACKGROUND: The Institute of Medicine (IOM) standards for guideline development have had unintended negative consequences. A more efficient approach is desirable. OBJECTIVE: To determine whether a modified Delphi process early during guideline development discriminates recommendations that should be informed by a systematic review from those that can be based upon expert consensus. METHODS: The same questions addressed by IOM-compliant pulmonary or critical care guidelines were addressed by expert panels using a modified Delphi process, the Convergence of Opinion on Recommendations and Evidence (CORE) process...
July 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28721616/the-mining-sector-of-liberia-current-practices-and-environmental-challenges
#12
EDITORIAL
Samuel T K Wilson, Hongtao Wang, Martin Kabenge, Xuejiao Qi
Liberia is endowed with an impressive stock of mineral reserves and has traditionally relied on mining, namely iron ore, gold, and diamonds, as a major source of income. The recent growth in the mining sector has the potential to contribute significantly to employment, income generation, and infrastructure development. However, the development of these mineral resources has significant environmental impacts that often go unnoticed. This paper presents an overview of the Liberian mining sector from historical, current development, and economic perspectives...
July 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28721354/diagnostic-outcomes-after-chest-radiograph-interpretation-in-patients-with-suspected-tuberculosis-and-negative-sputum-smears-in-a-high-burden-human-immunodeficiency-virus-and-tuberculosis-setting
#13
Patrick G T Cudahy, Rodney Dawson, Brian W Allwood, Gary Maartens, Douglas Wilson
BACKGROUND: Evaluation of patients with suspected tuberculosis and negative sputum smears for acid-fast bacilli (AFB) is challenging, especially in high human immunodeficiency virus coinfection settings where sputum smears have lower sensitivity for detecting AFB. METHODS: We examined the utility of chest radiographs for detecting smear-negative pulmonary tuberculosis. Three hundred sixty sputum smear-negative patients who were referred from primary care clinics in the KwaZulu-Natal province of South Africa were evaluated...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28699409/review-of-the-effectiveness-of-enteral-feeding-in-pediatric-oncology-patients
#14
Kaleena Trimpe, Michele R Shaw, Marian Wilson, Mel R Haberman
Enteral supplementation for nutritional support in pediatric oncology patients remains nonstandardized across institutions and between providers. Pediatric oncology patients frequently fail to meet their growth curve percentiles, lose weight, and/or are malnourished due to both the oncologic process as well as side effects from chemotherapy and radiation treatments. Methods of increasing weight include enteral feeding (nasogastric, nasoduodenal/jejunal, or gastrostomy), parenteral intravenous feeding, and oral supplementation...
July 1, 2017: Journal of Pediatric Oncology Nursing: Official Journal of the Association of Pediatric Oncology Nurses
https://www.readbyqxmd.com/read/28692719/electrocardiograms-in-low-risk-patients-undergoing-an-annual-health-examination
#15
R Sacha Bhatia, Zachary Bouck, Noah M Ivers, Graham Mecredy, Jasjit Singh, Ciara Pendrith, Dennis T Ko, Danielle Martin, Harindra C Wijeysundera, Jack V Tu, Lynn Wilson, Kimberly Wintemute, Paul Dorian, Joshua Tepper, Peter C Austin, Richard H Glazier, Wendy Levinson
Importance: Clinical guidelines advise against routine electrocardiograms (ECG) in low-risk, asymptomatic patients, but the frequency and impact of such ECGs are unknown. Objective: To assess the frequency of ECGs following an annual health examination (AHE) with a primary care physician among patients with no known cardiac conditions or risk factors, to explore factors predictive of receiving an ECG in this clinical scenario, and to compare downstream cardiac testing and clinical outcomes in low-risk patients who did and did not receive an ECG after their AHE...
July 10, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28688809/use-of-the-spot-vision-screener-for-patients-with-developmental-disability
#16
Amanda L Marzolf, M Millicent Peterseim, Blake D Forcina, Carrie Papa, M Edward Wilson, Edward W Cheeseman, Rupal H Trivedi
PURPOSE: To determine whether the Spot Vision Screener effectively detects amblyopia risk factors (ARFs) in patients with developmental disability using the 2013 guidelines of the American Association for Pediatric Ophthalmology and Strabismus (AAPOS). METHODS: Children with developmental disability presenting for complete pediatric ophthalmologic examination were prospectively enrolled between June 2012 and March 2016. The following data were analyzed: presence of ARFs according to the AAPOS guidelines, refraction, eye alignment, and other ocular pathology...
July 5, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28685179/management-of-common-ailments-requiring-referral-in-the-pharmacy-a-mystery-shopping-intervention-study
#17
Jack Charles Collins, Carl Richard Schneider, Renee Faraj, Frances Wilson, Abilio Cesar de Almeida Neto, Rebekah Jane Moles
Background Pharmacists can play a key role in managing ailments through their primary roles of supplying over-the-counter (non-prescription) medicines and advice-giving. It must be ensured that pharmacy staff practise in an evidence-based, guideline-compliant manner. To achieve this, mystery shopping can be used as an intervention to assess and train pharmacy staff. Objective To determine if repeated student pharmacist mystery shopping with immediate feedback affected the outcome of scenarios requiring referral to a medical practitioner...
August 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28666205/re-examining-blood-donor-deferral-criteria-relating-to-injecting-drug-use
#18
Brendan Quinn, Clive Seed, Anthony Keller, Lisa Maher, David Wilson, Michael Farrell, Sharon Caris, Jennifer Williams, Annie Madden, Alexander Thompson, Joanne Pink, Margaret E Hellard
BACKGROUND AND AIMS: Potential Australian blood donors are deferred indefinitely if they report a history of injecting drug use (IDU), or for 12 months if they report having engaged in sexual activity with someone who might have ever injected. Given incremental improvements in blood safety, this study sought to examine whether Australia's IDU-related eligibility criteria reflected current scientific evidence, were consistent with international best practice and, if current IDU-related policies were to be changed, how this should happen...
June 27, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28665879/-at-our-age-we-would-like-to-do-things-the-way-we-want-a-qualitative-study-of-adolescent-hiv-testing-services-in-kenya
#19
Kate S Wilson, Kristin M Beima-Sofie, Helen Moraa, Anjuli D Wagner, Cyrus Mugo, Peter M Mutiti, Dalton Wamalwa, David Bukusi, Grace C John-Stewart, Jennifer A Slyker, Pamela K Kohler, Gabrielle O'Malley
OBJECTIVES: Adolescents in Africa have low HIV testing rates. Better understanding of adolescent, provider, and caregiver experiences in high-burden countries such as Kenya could improve adolescent HIV testing programs. DESIGN: We conducted 16 qualitative interviews with HIV-positive and HIV-negative adolescents (13-18 years) and six focus group discussions with Healthcare workers (HCWs) and caregivers of adolescents in Nairobi, Kenya. METHODS: Semi-structured interviews and focus groups were recorded and transcribed...
July 1, 2017: AIDS
https://www.readbyqxmd.com/read/28665705/summary-for-clinicians-lymphangioleiomyomatosis-diagnosis-and-management-clinical-practice-guideline
#20
Laura C Feemster, Patrick G Lyons, Rohini S Chatterjee, Pranav Kidambi, Francis X McCormack, Joel Moss, Kevin C Wilson, Carey C Thomson
No abstract text is available yet for this article.
July 2017: Annals of the American Thoracic Society
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