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https://www.readbyqxmd.com/read/28337621/metal-contaminated-potato-crops-and-potential-human-health-risk-in-bolivian-mining-highlands
#1
Alan E Garrido, William H J Strosnider, Robin Taylor Wilson, Janette Condori, Robert W Nairn
This study assessed metals in irrigation water, soil and potato crops impacted by mining discharges, as well as potential human health risk in the high desert near the historic mining center of Potosí, Bolivia. Metal concentrations were compared with international concentration limit guidelines. In addition, an ingested average daily dose and minimum risk level were used to determine the hazard quotient from potato consumption for adults and children. Irrigation water maximum concentrations of Cd, Pb and Zn in mining-impacted sites were elevated 20- to 1100-fold above international concentration limit guidelines...
March 23, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28336401/performance-of-the-spot-vision-screener-in-children-younger-than-three-years-of-age
#2
Blake D Forcina, M Millicent Peterseim, M Edward Wilson, Edward W Cheeseman, Samuel Feldman, Amanda L Marzolf, Bethany J Wolf, Rupal H Trivedi
PURPOSE: To evaluate the use of the Spot Vision Screener (Spot; Welch Allyn, Skaneateles Falls, NY) for detection of amblyopia risk factors in children aged 6 months to 3 years, as defined by the 2013 guidelines of the American Association for Pediatric Ophthalmology and Strabismus. DESIGN: Reliability analysis METHODS: In this study, children seen from 01 June 2012 to 30 April 2016 were tested with the Spot during a routine visit. Enrolled children underwent a comprehensive eye examination including cycloplegic refraction and sensorimotor testing within six months of the testing date by a pediatric ophthalmologist masked to the Spot results...
March 20, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28329125/outcomes-in-patients-with-cardiovascular-implantable-electronic-device-infection-managed-with-chronic-antibiotic-suppression
#3
Eugene M Tan, Daniel C DeSimone, M Rizwan Sohail, Larry M Baddour, Walter R Wilson, James M Steckelberg, Abinash Virk
Background: Most cardiovascular implantable electronic device (CIED) recipients are elderly, have multiple comorbid conditions, and are at increased risk of CIED infection (CIEDI). Current guidelines recommend complete device removal in patients with CIEDI to prevent relapse and mortality. However, comorbidities or other factors may preclude device removal, thus prompting a non-surgical approach that includes chronic antibiotic suppression (CAS). There are limited data on outcomes of patients receiving CAS for CIEDI...
February 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28328531/provider-variability-in-the-initial-diagnosis-and-treatment-of-congenital-hypothyroidism
#4
Luke Cielonko, Tyler Hamby, John S Dallas, Luke Hamilton, Don P Wilson
BACKGROUND: Early diagnosis and expeditious treatment of newborns with congenital hypothyroidism (CH) is necessary to avoid mental retardation. METHODS: A survey of 44 practitioners in the southern US was conducted to better understand common practices regarding neonatal CH and the findings were compared with current guidelines in the US and Europe. RESULTS: Responses indicated some consensus that 10-15 μg of thyroid hormone/kg/day was the appropriate dosage...
March 22, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28323194/international-experts-practice-in-the-antibiotic-therapy-of-infective-endocarditis-is-not-following-the-guidelines
#5
H Tissot-Dupont, J P Casalta, F Gouriet, S Hubert, E Salaun, G Habib, M P Fernandez-Gerlinger, J L Mainardi, P Tattevin, M Revest, F Lucht, E Botelho-Nevers, A Gagneux-Brunon, U Snygg-Martin, K L Chan, J Bishara, I Vilacosta, C Olmos, J A San Román, J López, P Tornos, N Fernández-Hidalgo, E Durante-Mangoni, R Utili, M Paul, L M Baddour, D C De Simone, M R Sohail, J M Steckelberg, W R Wilson, D Raoult
OBJECTIVE: The management of infective endocarditis (IE) may differ from international guidelines, even in reference centers. This is probably due to the fact that most recommendations are not based on hard evidence, so that the consensus obtained for the guidelines does not represent actual practices. For this reason, we aimed at evaluating this question in the particular field of antibiotic therapy. METHODS: Thirteen international centers specialized in the management of IE were selected, according to their reputation, clinical results, original research publications and quotations...
March 18, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28321267/is-endocarditis-prophylaxis-for-dental-procedures-necessary
#6
COMMENT
Kathryn A Taubert, Walter Wilson
OBJECTIVES: Our purpose is to address whether antimicrobial prophylaxis is necessary before certain dental procedures for patients at increased risk for acquiring infective endocarditis (IE). METHODS: We reviewed recommendations for IE prophylaxis made by the American Heart Association (AHA) from 1995 to the present time. We also compared and contrasted the current recommendations from the AHA, European Society of Cardiology (ESC), United Kingdom's National Institute for Health and Care Excellence (NICE) and a consortium of French organisations...
2017: Heart Asia
https://www.readbyqxmd.com/read/28320342/enhanced-recovery-after-elective-caesarean-a-rapid-review-of-clinical-protocols-and-an-umbrella-review-of-systematic-reviews
#7
Ellena Corso, Daniel Hind, Daniel Beever, Gordon Fuller, Matthew J Wilson, Ian J Wrench, Duncan Chambers
BACKGROUND: The rate of elective Caesarean Section (CS) is rising in many countries. Many obstetric units in the UK have either introduced or are planning to introduce enhanced recovery (ER) as a means of reducing length of stay for planned CS. However, to date there has been very little evidence produced regarding the necessary components of ER for the obstetric population. We conducted a rapid review of the composition of published ER pathways for elective CS and undertook an umbrella review of systematic reviews evaluating ER components and pathways in any surgical setting...
March 20, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28317015/evaluation-of-the-2015-aga-guidelines-on-pancreatic-cystic-neoplasms-in-a-large-surgically-confirmed-multicenter-cohort
#8
Phillip S Ge, V Raman Muthusamy, Srinivas Gaddam, Diana-Marie Jaiyeola, Stephen Kim, Alireza Sedarat, Timothy R Donahue, Lindsay Hosford, Robert H Wilson, David P Grande, Rajesh N Keswani, Vladimir M Kushnir, Daniel Mullady, Steven A Edmundowicz, Dayna S Early, Srinadh Komanduri, Sachin Wani, Rabindra R Watson
Background and study aims The American Gastroenterological Association (AGA) recently published guidelines for the management of asymptomatic pancreatic cystic neoplasms (PCNs). We aimed to evaluate the diagnostic characteristics of the AGA guidelines in appropriately recommending surgery for malignant PCNs. Patients and methods A retrospective multicenter study was performed of patients who underwent endoscopic ultrasound (EUS) for evaluation of PCNs who ultimately underwent surgical resection from 2004 - 2014...
March 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28298398/management-of-copd-exacerbations-a%C3%A2-european-respiratory-society-american-thoracic-society-guideline
#9
Jadwiga A Wedzicha, Marc Miravitlles, John R Hurst, Peter M A Calverley, Richard K Albert, Antonio Anzueto, Gerard J Criner, Alberto Papi, Klaus F Rabe, David Rigau, Pawel Sliwinski, Thomy Tonia, Jørgen Vestbo, Kevin C Wilson, Jerry A Krishnan
This document provides clinical recommendations for treatment of chronic obstructive pulmonary disease (COPD) exacerbations.Comprehensive evidence syntheses, including meta-analyses, were performed to summarise all available evidence relevant to the Task Force's questions. The evidence was appraised using the Grading of Recommendations, Assessment, Development and Evaluation approach and the results were summarised in evidence profiles. The evidence syntheses were discussed and recommendations formulated by a multidisciplinary Task Force of COPD experts...
March 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28294090/evaluation-of-staphylococcus-aureus-bacteremia-academic-and-community-based-management-within-the-same-health-system
#10
Sumaya Ased, Hamza Rayes, Jaspreet Dhami, Nick Amosson, Akua Fordjour, Jeff Macaraeg, Renuga Vivekanandan, Josh Wilson, Annie Cabri, Michele Davids, Jennifer Anthone, Stephen Cavalieri, Christopher J Destache
A nonrandomized, retrospective comparison of Staphylococcus aureus bacteremia between an academic hospital setting (n=53) and a community hospital setting (n=245) within a single healthcare system was performed. Despite infectious disease consultations, S. aureus bacteremia management recommendations based on Infectious Diseases Society of America (IDSA) guidelines were not followed as closely in the community hospital setting. The community hospital setting requires management standardization for patients with S...
March 15, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28291589/therapy-for-relapsed-multiple-myeloma-guidelines-from-the-mayo-stratification-for-myeloma-and-risk-adapted-therapy
#11
REVIEW
David Dingli, Sikander Ailawadhi, P Leif Bergsagel, Francis K Buadi, Angela Dispenzieri, Rafael Fonseca, Morie A Gertz, Wilson I Gonsalves, Susan R Hayman, Prashant Kapoor, Taxiarchis Kourelis, Shaji K Kumar, Robert A Kyle, Martha Q Lacy, Nelson Leung, Yi Lin, John A Lust, Joseph R Mikhael, Craig B Reeder, Vivek Roy, Stephen J Russell, Taimur Sher, A Keith Stewart, Rahma Warsame, Stephen R Zeldenrust, S Vincent Rajkumar, Asher A Chanan Khan
Life expectancy in patients with multiple myeloma is increasing because of the availability of an increasing number of novel agents with various mechanisms of action against the disease. However, the disease remains incurable in most patients because of the emergence of resistant clones, leading to repeated relapses of the disease. In 2015, 5 novel agents were approved for therapy for relapsed multiple myeloma. This surfeit of novel agents renders management of relapsed multiple myeloma more complex because of the occurrence of multiple relapses, the risk of cumulative and emergent toxicity from previous therapies, as well as evolution of the disease during therapy...
March 10, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28291487/physical-screening-predictors-for-success-in-completing-air-force-phase-ii-air-liaison-officer-aptitude-assessment
#12
John Christopher McGee, Eric Wilson, Haley Barela, Sharon Blum
OBJECTIVES: Air Liaison Officer Aptitude Assessment (AAA) attrition is often associated with a lack of candidate physical preparation. The Functional Movement Screen, Tactical Fitness Assessment, and fitness metrics were collected (n = 29 candidates) to determine what physical factors could predict a candidate s success in completing AAA. METHODS: Between-group comparisons were made between candidates completing AAA versus those who did not (p < 0.05). Upper 50% thresholds were established for all variables with R(2) < 0...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28289251/the-evolution-of-transmission-mode
#13
REVIEW
Janis Antonovics, Anthony J Wilson, Mark R Forbes, Heidi C Hauffe, Eva R Kallio, Helen C Leggett, Ben Longdon, Beth Okamura, Steven M Sait, Joanne P Webster
This article reviews research on the evolutionary mechanisms leading to different transmission modes. Such modes are often under genetic control of the host or the pathogen, and often in conflict with each other via trade-offs. Transmission modes may vary among pathogen strains and among host populations. Evolutionary changes in transmission mode have been inferred through experimental and phylogenetic studies, including changes in transmission associated with host shifts and with evolution of the unusually complex life cycles of many parasites...
May 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28288285/reply-to-official-ats-jrs-clinical-practice-guidelines-lymphangioleiomyomatosis-diagnosis-and-management
#14
Francis X McCormack, Nishant Gupta, Geraldine Finlay, Lisa R Young, Simon Johnson, Vincent Cottin, Kevin Wilson, Joel Moss
No abstract text is available yet for this article.
March 13, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28284756/feasibility-and-association-of-neurohumoral-blocker-uptitration-following-cardiac-resynchronization-therapy
#15
Pieter Martens, Frederik H Verbrugge, Petra Nijst, Philippe Pb Bertrand, Matthias Dupont, Wilson Wh Tang, Wilfried Mullens
BACKGROUND Cardiac resynchronization therapy (CRT) improves mortality and morbidity on top of optimal medical therapy in heart failure with reduced ejection fraction (HFrEF). This study aims to elucidate the association between neurohumoral blocker uptitration following CRT-implantation and clinical outcome. METHODS & RESULTS Doses of angiotensin-converting enzyme inhibitors (ACE-I), angiotensin receptor blockers (ARB) and beta-blockers were retrospectively evaluated in 650 consecutive CRT patients implanted between October 2008 and August 2015 and followed in a tertiary multi-disciplinary CRT clinic...
March 8, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28281082/epidemiology-prevention-and-potential-future-treatments-of-sexually-transmitted-zika-virus-infection
#16
REVIEW
Davidson H Hamer, Mary E Wilson, Jenny Jean, Lin H Chen
PURPOSE OF REVIEW: While mosquitoes have been primarily responsible for outbreaks of Zika virus worldwide, most prominently in the Americas during 2015 and 2016, there has been increased recognition of the importance of sexual transmission. We review human reports and animal model studies of Zika sexual transmission and summarize potential therapeutic candidates. RECENT FINDINGS: Male-to-female, male-to-male, and female-to-male transmission has been reported, among unprotected sexual contacts of returning travelers...
April 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28267075/surgical-management-of-crohn-disease-in-children-guidelines-from-the-paediatric-ibd-porto-group-of-espghan
#17
Jorge Amil-Dias, Sanja Kolacek, Dan Turner, Anders Pærregaard, Risto Rintala, Nadeem Ahmad Afzal, Katarzyna Karolewska-Bochenek, Jiri Bronsky, Sonny Chong, John Fell, Iva Hojsak, Jean-Pierre Hugot, Sibylle Koletzko, Devinder Kumar, Izabella Lazowska-Przeorek, Craig Lillehei, Paolo Lionetti, Javier Martin-de-Carpi, Mikko Pakarinen, Frank M Ruemmele, Ron Shaoul, Christine Spray, Annamaria Staiano, Ian Sugarman, David C Wilson, Harland Winter, Kaija-Leena Kolho
The incidence of Crohn's disease (CD) has been increasing and surgery needs to be contemplated in a substantial number of cases. The relevant advent of biological treatment has changed but not eliminated the need for surgery in many patients. Despite previous publications on the indications for surgery in CD there was a need for a comprehensive review of existing evidence on the role of elective surgery and options in pediatric patients affected with CD. We present an expert opinion and critical review of the literature to provide evidence-based guidance to manage these patients...
March 6, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28220712/a-novel-quantitative-method-for-recovering-precipitated-uric-acid-in-urine-and-analysis-by-lc-ms-ms
#18
Lifang Sun, Dongmei Zhou, David M Wilson
AIM: Precipitation of uric acid (UA) in human urine had caused poor recovery and underestimation of UA in study samples. RESULTS: A UA recovery method was developed for analyzing frozen urine samples that potentially contain precipitated UA. Samples were treated with 3% v/v of a solution containing 8 M potassium hydroxide and 20% v/v of ammonium thioglycolate. The high pH enables rapid dissolution of UA crystals, while the thioglycolate protects UA from oxidation at high pH...
March 2017: Bioanalysis
https://www.readbyqxmd.com/read/28220480/quality-and-stability-of-extemporaneous-pyridoxal-phosphate-preparations-used-in-the-treatment-of-paediatric-epilepsy
#19
Abeer H A Mohamed-Ahmed, Matthew P Wilson, Maedelyn Albuera, Ting Chen, Philippa B Mills, Emma J Footitt, Peter T Clayton, Catherine Tuleu
OBJECTIVES: To assess the pyridoxal 5'-phosphate (PLP) content and stability of extemporaneous PLP liquids prepared from dietary supplements used for the treatment of vitamin B6 -dependent epilepsy. METHODS: Pyridoxal 5'-phosphate liquids were prepared in accordance with the guidelines given to patients from marketed 50 mg PLP dietary capsules and tablets. The PLP content and its stability were evaluated under conditions resembling the clinical setting using reverse phase HPLC and mass spectrometry...
April 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28218935/family-medicine-global-health-fellowship-competencies-a-modified-delphi-study
#20
Fadya El Rayess, Anna Filip, Anna Doubeni, Calvin Wilson, Cynthia Haq, Marc Debay, Gowri Anandarajah, Warren Heffron, Neil Jayasekera, Paul Larson, Bruce Dahlman, Olga Valdman, Vince Hunt
BACKGROUND AND OBJECTIVES: Many US medical schools and family medicine departments have responded to a growing interest in global health by developing global health fellowships. However, there are no guidelines or consensus statements outlining competencies for global health fellows. Our objective was to develop a mission and core competencies for Family Medicine Global Health Fellowships. METHODS: A modified Delphi technique was used to develop consensus on fellowship competencies...
February 2017: Family Medicine
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