keyword
https://read.qxmd.com/read/36109292/the-role-of-contemporary-wearable-and-handheld-devices-in-the-diagnosis-and-management-of-cardiac-arrhythmias
#21
REVIEW
Kartheek Garikapati, Samual Turnbull, Richard G Bennett, Timothy G Campbell, Juliana Kanawati, Mary S Wong, Stuart P Thomas, Clara K Chow, Saurabh Kumar
Cardiac arrhythmias are associated with significant morbidity, mortality and economic burden on the health care system. Detection and surveillance of cardiac arrhythmias using medical grade non-invasive methods (electrocardiogram, Holter monitoring) is the accepted standard of care. Whilst their accuracy is excellent, significant limitations remain in terms of accessibility, ease of use, cost, and a suboptimal diagnostic yield (up to ∼50%) which is critically dependent on the duration of monitoring. Contemporary wearable and handheld devices that utilise photoplethysmography and the electrocardiogram present a novel opportunity for remote screening and diagnosis of arrhythmias...
September 12, 2022: Heart, Lung & Circulation
https://read.qxmd.com/read/35916132/multinational-federated-learning-approach-to-train-ecg-and-echocardiogram-models-for-hypertrophic-cardiomyopathy-detection
#22
JOURNAL ARTICLE
Shinichi Goto, Divyarajsinhji Solanki, Jenine E John, Ryuichiro Yagi, Max Homilius, Genki Ichihara, Yoshinori Katsumata, Hanna K Gaggin, Yuji Itabashi, Calum A MacRae, Rahul C Deo
BACKGROUND: Novel targeted treatments increase the need for prompt hypertrophic cardiomyopathy (HCM) detection. However, its low prevalence (0.5%) and resemblance to common diseases present challenges that may benefit from automated machine learning-based approaches. We aimed to develop machine learning models to detect HCM and to differentiate it from other cardiac conditions using ECGs and echocardiograms, with robust generalizability across multiple cohorts. METHODS: Single-institution HCM ECG models were trained and validated on external data...
September 6, 2022: Circulation
https://read.qxmd.com/read/35862102/cardiomyocyte-specific-long-noncoding-rna-regulates-alternative-splicing-of-the-triadin-gene-in-the-heart
#23
JOURNAL ARTICLE
Yuanbiao Zhao, Andrew S Riching, Walter E Knight, Congwu Chi, Lindsey J Broadwell, Yanmei Du, Mostafa Abdel-Hafiz, Amrut V Ambardekar, David C Irwin, Catherine Proenza, Hongyan Xu, Leslie A Leinwand, Lori A Walker, Kathleen C Woulfe, Michael R Bristow, Peter M Buttrick, Kunhua Song
BACKGROUND: Abnormalities in Ca2+ homeostasis are associated with cardiac arrhythmias and heart failure. Triadin plays an important role in Ca2+ homeostasis in cardiomyocytes. Alternative splicing of a single triadin gene produces multiple triadin isoforms. The cardiac-predominant isoform, mouse MT-1 or human Trisk32, is encoded by triadin exons 1 to 8. In humans, mutations in the triadin gene that lead to a reduction in Trisk32 levels in the heart can cause cardiac dysfunction and arrhythmias...
July 18, 2022: Circulation
https://read.qxmd.com/read/35861794/ecg-challenge-electric-extremis-in-a-critically-ill-patient
#24
JOURNAL ARTICLE
Royce Kim, Jeffrey Kolominsky, Kenneth A Ellenbogen
No abstract text is available yet for this article.
May 3, 2022: Circulation
https://read.qxmd.com/read/35698972/from-bedside-to-balloon-the-challenges-of-in-hospital-st-elevation-myocardial-infarction
#25
JOURNAL ARTICLE
Mena Gewarges, Hani Amad, Adriana Luk
No abstract text is available yet for this article.
June 14, 2022: Circulation. Cardiovascular Quality and Outcomes
https://read.qxmd.com/read/35617207/plasma-micrornas-as-noninvasive-diagnostic-biomarkers-in-patients-with-brugada-syndrome
#26
JOURNAL ARTICLE
Yoshihiro Ikeuchi, Hidenori Ochi, Chikaaki Motoda, Takehito Tokuyama, Yousaku Okubo, Sho Okamura, Syunsuke Miyauchi, Shogo Miyamoto, Yukimi Uotani, Yuko Onohara, Mika Nakashima, Rie Akiyama, Hidetoshi Tahara, Kazuaki Chayama, Yasuki Kihara, Yukiko Nakano
BACKGROUND: Brugada syndrome (BrS) can be diagnosed by a type 1 BrS tracing in a 12-lead electrocardiogram (ECG). However, there are daily variations in the ECGs of BrS patients, which presents a challenge when diagnosing BrS. Although many susceptibility genes have been identified, the SCN5A gene is reportedly the main causative gene of BrS. However, most patients do not have an evidence of genetic predisposition to develop BrS. In addition, the diagnosis and risk stratification for ventricular fibrillation (VF) in patients with BrS presents some problems...
2022: PloS One
https://read.qxmd.com/read/35500052/ecg-challenge-electric-extremis-in-a-critically-ill-patient
#27
JOURNAL ARTICLE
Royce Kim, Jeffrey Kolominsky, Kenneth A Ellenbogen
No abstract text is available yet for this article.
May 3, 2022: Circulation
https://read.qxmd.com/read/35461619/found-down-approach-to-the-patient-with-an-unknown-poisoning
#28
REVIEW
Mehruba Anwar Parris, Diane P Calello
Approximately 30% of poison exposures reported to centers each year are either referred to or initiated within a health care facility. Among these exposures, undifferentiated poisoned patients are among the most challenging cases faced in the emergency department. Airway, breathing, circulation (ABCs) is central to the management of unknown poisoned patient. After initial stabilization, taking a systematic approach presented here may be beneficial to the clinician. This includes considering key additional history, a possible toxidrome, and data in the form of vital signs, physical examination, laboratory analysis, ECG, and imaging...
May 2022: Emergency Medicine Clinics of North America
https://read.qxmd.com/read/35333097/p-wave-parameters-and-indices-a-critical-appraisal-of-clinical-utility-challenges-and-future-research-a-consensus-document-endorsed-by-the-international-society-of-electrocardiology-and-the-international-society-for-holter-and-noninvasive-electrocardiology
#29
REVIEW
Lin Yee Chen, Antonio Luiz Pinho Ribeiro, Pyotr G Platonov, Iwona Cygankiewicz, Elsayed Z Soliman, Bulent Gorenek, Takanori Ikeda, Vassilios P Vassilikos, Jonathan S Steinberg, Niraj Varma, Antoni Bayés-de-Luna, Adrian Baranchuk
Atrial cardiomyopathy, characterized by abnormalities in atrial structure and function, is associated with increased risk of adverse cardiovascular and neurocognitive outcomes, independent of atrial fibrillation. There exists a critical unmet need for a clinical tool that is cost-effective, easy to use, and that can diagnose atrial cardiomyopathy. P wave parameters (PWPs) reflect underlying atrial structure, size, and electrical activation; alterations in these factors manifest as abnormalities in PWPs that can be readily ascertained from a standard 12-lead ECG and potentially be used to aid clinical decision-making...
April 2022: Circulation. Arrhythmia and Electrophysiology
https://read.qxmd.com/read/35089057/predicting-atrial-fibrillation-recurrence-by-combining-population-data-and-virtual-cohorts-of-patient-specific-left-atrial-models
#30
JOURNAL ARTICLE
Caroline H Roney, Iain Sim, Jin Yu, Marianne Beach, Arihant Mehta, Jose Alonso Solis-Lemus, Irum Kotadia, John Whitaker, Cesare Corrado, Orod Razeghi, Edward Vigmond, Sanjiv M Narayan, Mark O'Neill, Steven E Williams, Steven A Niederer
BACKGROUND: Current ablation therapy for atrial fibrillation is suboptimal, and long-term response is challenging to predict. Clinical trials identify bedside properties that provide only modest prediction of long-term response in populations, while patient-specific models in small cohorts primarily explain acute response to ablation. We aimed to predict long-term atrial fibrillation recurrence after ablation in large cohorts, by using machine learning to complement biophysical simulations by encoding more interindividual variability...
February 2022: Circulation. Arrhythmia and Electrophysiology
https://read.qxmd.com/read/34623540/kv1-3-channel-blockade-improves-inflammatory-profile-reduces-cardiac-electrical-remodeling-and-prevents-arrhythmia-in-type-2-diabetic-rats
#31
JOURNAL ARTICLE
Julián Zayas-Arrabal, Amaia Alquiza, Ainhoa Rodríguez-de-Yurre, Leyre Echeazarra, Víctor Fernández-López, Mónica Gallego, Oscar Casis
PURPOSE: Kv1.3 channel regulates the activity of lymphocytes, macrophages, or adipose tissue and its blockade reduces inflammatory cytokine secretion and improves insulin sensitivity in animals with metabolic syndrome and in genetically obese mice. Thus, Kv1.3 blockade could be a strategy for the treatment of type 2 diabetes. Elevated circulating levels of TNFα and IL-1b mediate the higher susceptibility to cardiac arrhythmia in type 2 diabetic rats. We hypothesized that Kv1.3 channel blockade with the psoralen PAP1 could have immunomodulatory properties that prevent QTc prolongation and reduce the risk of arrhythmia in type 2 diabetic rats...
October 8, 2021: Cardiovascular Drugs and Therapy
https://read.qxmd.com/read/34277733/a-review-of-biomarkers-for-ischemic-stroke-evaluation-in-patients-with-non-valvular-atrial-fibrillation
#32
REVIEW
Luxiang Shang, Ling Zhang, Yankai Guo, Huaxin Sun, Xiaoxue Zhang, Yakun Bo, Xianhui Zhou, Baopeng Tang
Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia worldwide and results in a significantly increased ischemic stroke (IS) risk. IS risk stratification tools are widely being applied to guide anticoagulation treatment decisions and duration in patients with non-valvular AF (NVAF). The CHA2 DS2 -VASc score is largely validated and currently recommended by renowned guidelines. However, this score is heavily dependent on age, sex, and comorbidities, and exhibits only moderate predictive power. Finding effective and validated clinical biomarkers to assist in personalized IS risk evaluation has become one of the promising directions in the prevention and treatment of NVAF...
2021: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/34202017/molecular-and-electrophysiological-role-of-diabetes-associated-circulating-inflammatory-factors-in-cardiac-arrhythmia-remodeling-in-a-metabolic-induced-model-of-type-2-diabetic-rat
#33
JOURNAL ARTICLE
Julian Zayas-Arrabal, Amaia Alquiza, Erkan Tuncay, Belma Turan, Monica Gallego, Oscar Casis
BACKGROUND: Diabetic patients have prolonged cardiac repolarization and higher risk of arrhythmia. Besides, diabetes activates the innate immune system, resulting in higher levels of plasmatic cytokines, which are described to prolong ventricular repolarization. METHODS: We characterize a metabolic model of type 2 diabetes (T2D) with prolonged cardiac repolarization. Sprague-Dawley rats were fed on a high-fat diet (45% Kcal from fat) for 6 weeks, and a low dose of streptozotozin intraperitoneally injected at week 2...
June 25, 2021: International Journal of Molecular Sciences
https://read.qxmd.com/read/34121829/covid-19-associated-multisystem-inflammatory-syndrome-in-children-mis-c-guidelines-revisiting-the-western-new-york-approach-as-the-pandemic-evolves
#34
EDITORIAL
Teresa R Hennon, Karl O A Yu, Michelle D Penque, Rabheh Abdul-Aziz, Arthur C Chang, Megan B McGreevy, John V Pastore, Andrew J Prout, Beverly A Schaefer, Omar S Alibrahim, Oscar G Gomez-Duarte, Mark D Hicar
Multisystem inflammatory syndrome of children (MIS-C) continues to be a highly concerning diagnosis in those recently infected with SARS-CoV-2. The diagnosis of MIS-C cases will likely become even more challenging as vaccine uptake and natural immunity in previously infected persons leads to lower circulating rates of SARS-CoV-2 infection and will make cases sporadic. Febrile children presenting with cardiac dysfunction, symptoms overlapping Kawasaki disease or significant gastrointestinal complaints warrant a thorough screen in emergency departments, urgent care centers, and outpatient pediatric or family medicine practices...
September 2021: Progress in Pediatric Cardiology
https://read.qxmd.com/read/34003839/assessment-of-the-evolution-of-end-tidal-carbon-dioxide-within-chest-compression-pauses-to-detect-restoration-of-spontaneous-circulation
#35
JOURNAL ARTICLE
Jose Julio Gutiérrez, Mikel Leturiondo, Sofía Ruiz de Gauna, Jesus María Ruiz, Izaskun Azcarate, Digna María González-Otero, Juan Francisco Urtusagasti, James Knox Russell, Mohamud Ramzan Daya
BACKGROUND: Measurement of end-tidal CO2 (ETCO2) can help to monitor circulation during cardiopulmonary resuscitation (CPR). However, early detection of restoration of spontaneous circulation (ROSC) during CPR using waveform capnography remains a challenge. The aim of the study was to investigate if the assessment of ETCO2 variation during chest compression pauses could allow for ROSC detection. We hypothesized that a decay in ETCO2 during a compression pause indicates no ROSC while a constant or increasing ETCO2 indicates ROSC...
2021: PloS One
https://read.qxmd.com/read/33999698/durable-physiological-changes-and-decreased-syncope-burden-12-months-after-unifocal-right-sided-ablation-under-computed-tomographic-guidance-in-patients-with-neurally-mediated-syncope-or-functional-sinus-node-dysfunction
#36
JOURNAL ARTICLE
Philippe Debruyne, Tom Rossenbacker, Luc Janssens, Christine Collienne, Joris Ector, Peter Haemers, Jean-Benoît le Polain de Waroux, Christine Bazelmans, Tim Boussy, William Wijns
Background - Cardio-neuromodulation (CardNM) is a cardioneuroablative approach aiming to create adequate vagolysis of the sinoatrial node through partial ablation of the anterior right ganglionated plexus. Methods - We performed an interventional study in patients with recurrent neurally mediated syncope (group A) or functional sinus node (SN) dysfunction (group B). Syncope burden, electrocardiogram, 24-h rhythm data, tilt table test, exercise test, and pharmacological challenge with atropine were assessed at baseline and at regular intervals to 12-months...
May 17, 2021: Circulation. Arrhythmia and Electrophysiology
https://read.qxmd.com/read/33899815/immediate-postcardiac-arrest-treatment-coronary-catherization-or-not
#37
REVIEW
Florence Dumas, Wulfran Bougouin, Alain Cariou
PURPOSE OF REVIEW: Early coronary angiogram (CAG) remains a cornerstone in postcardiac arrest management as coronary disease (CAD)-related cardiac arrest is the leading cause of sudden death in adults. The opportunity to treat the cause early on with immediate CAG may improve outcome in cardiac arrest patients with AMI. Identifying the patients who will benefit from such an early invasive strategy is an unanswered question. Recent and ongoing trials may improve the level of evidence on this problematic, especially for some subgroup; however, current guidelines remain founded upon a very heterogeneous level of evidence...
June 1, 2021: Current Opinion in Critical Care
https://read.qxmd.com/read/33807882/prediction-of-neurologically-intact-survival-in-cardiac-arrest-patients-without-pre-hospital-return-of-spontaneous-circulation-machine-learning-approach
#38
JOURNAL ARTICLE
Dong-Woo Seo, Hahn Yi, Hyun-Jin Bae, Youn-Jung Kim, Chang-Hwan Sohn, Shin Ahn, Kyoung-Soo Lim, Namkug Kim, Won-Young Kim
Current multimodal approaches for the prognostication of out-of-hospital cardiac arrest (OHCA) are based mainly on the prediction of poor neurological outcomes; however, it is challenging to identify patients expected to have a favorable outcome, especially before the return of spontaneous circulation (ROSC). We developed and validated a machine learning-based system to predict good outcome in OHCA patients before ROSC. This prospective, multicenter, registry-based study analyzed non-traumatic OHCA data collected between October 2015 and June 2017...
March 5, 2021: Journal of Clinical Medicine
https://read.qxmd.com/read/33740573/diagnostic-value-of-transthoracic-echocardiography-compared-to-electrocardiogram-in-predicting-coronary-artery-stenosis-among-patients-after-cardiac-arrest
#39
JOURNAL ARTICLE
Joochan Kim, Yong Soo Cho, Byung Kook Lee, Dong Hun Lee, Eujene Jung, Jeong Mi Moon, Byeong Jo Chun
BACKGROUND: In the absence of ST-segment elevation (STE) in post-return of spontaneous circulation (ROSC) electrocardiogram (ECG), coronary angiography (CAG) is required in patients with suspected coronary artery disease (CAD). However, it is a challenge to identify patients with CAD after cardiac arrest (CA). Recent European Society of Cardiology guidelines recommends transthoracic echocardiography in patients presenting with cardiac arrest. We aimed to assess the diagnostic value of regional wall motion abnormalities (RWMAs) on transthoracic echocardiography (TTE) compared to ECG in diagnosing significant coronary artery stenosis in CA patients...
March 1, 2021: American Journal of Emergency Medicine
https://read.qxmd.com/read/33600229/machine-learning-in-arrhythmia-and-electrophysiology
#40
JOURNAL ARTICLE
Natalia A Trayanova, Dan M Popescu, Julie K Shade
Machine learning (ML), a branch of artificial intelligence, where machines learn from big data, is at the crest of a technological wave of change sweeping society. Cardiovascular medicine is at the forefront of many ML applications, and there is a significant effort to bring them into mainstream clinical practice. In the field of cardiac electrophysiology, ML applications have also seen a rapid growth and popularity, particularly the use of ML in the automatic interpretation of ECGs, which has been extensively covered in the literature...
February 19, 2021: Circulation Research
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