Yuanbiao Zhao, Andrew S Riching, Walter E Knight, Congwu Chi, Lindsey J Broadwell, Yanmei Du, Mostafa Abdel-Hafiz, Amrut V Ambardekar, David C Irwin, Catherine Proenza, Hongyan Xu, Leslie A Leinwand, Lori A Walker, Kathleen C Woulfe, Michael R Bristow, Peter M Buttrick, Kunhua Song
BACKGROUND: Abnormalities in Ca2+ homeostasis are associated with cardiac arrhythmias and heart failure. Triadin plays an important role in Ca2+ homeostasis in cardiomyocytes. Alternative splicing of a single triadin gene produces multiple triadin isoforms. The cardiac-predominant isoform, mouse MT-1 or human Trisk32, is encoded by triadin exons 1 to 8. In humans, mutations in the triadin gene that lead to a reduction in Trisk32 levels in the heart can cause cardiac dysfunction and arrhythmias...
July 18, 2022: Circulation