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https://www.readbyqxmd.com/read/28427779/fish-oil-lc-pufas-do-not-affect-blood-coagulation-parameters-and-bleeding-manifestations-analysis-of-8-clinical-studies-with-selected-patient-groups-on-omega-3-enriched-medical-nutrition
#1
Stephanie Jeansen, Renger F Witkamp, Jossie A Garthoff, Ardy van Helvoort, Philip C Calder
BACKGROUND & AIMS: The increased consumption of fish oil enriched-products exposes a wide diversity of people, including elderly and those with impaired health to relatively high amounts of n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs). There is an ongoing debate around the possible adverse effects of n-3 LC-PUFAs on bleeding risk, particularly relevant in people with a medical history of cardiovascular events or using antithrombotic drugs. METHODS: This analysis of 8 clinical intervention studies conducted with enteral medical nutrition products containing fish oil as a source of n-3 LC-PUFAs addresses the occurrence of bleeding-related adverse events and effects on key coagulation parameters (Prothrombin Time [PT], (activated) and Partial Thromboplastin Time [(a)PTT])...
March 29, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28410575/effects-of-omega-3-fatty-acids-on-patients-undergoing-surgery-for-gastrointestinal-malignancy-a-systematic-review-and-meta-analysis
#2
REVIEW
Jing Yu, Lian Liu, Yue Zhang, Jia Wei, Fan Yang
BACKGROUND: Surgical resection remains the primary treatment for gastrointestinal (GI) malignancy including early-stage cancer. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been reported to have beneficial clinical and immune-modulating effects in the prognosis of GI cancer patients undergoing surgery. METHODS: We searched PubMed, Embase, EBSCO-Medline, Cochrane Central Register of Controlled Trials (CENTRAL), CNKI and Wanfang to identify primary research reporting the effects of n-3 PUFAs compared with isocaloric nutrition on GI cancer patients who underwent surgery up to the end of June 30, 2016...
April 14, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28356276/dietary-intake-and-adipose-tissue-content-of-long-chain-n-3-polyunsaturated-fatty-acids-and-subsequent-5-y-change-in-body-weight-and-waist-circumference
#3
Marianne U Jakobsen, Lise Madsen, Flemming Skjøth, Tina L Berentzen, Jytte Halkjær, Anne Tjønneland, Erik B Schmidt, Thorkild Ia Sørensen, Karsten Kristiansen, Kim Overvad
Background: Adding long-chain n-3 (ω-3) polyunsaturated fatty acids (PUFAs) to a rodent diet reduces fat mass and prevents the development of obesity, but evidence of a similar effect in humans is rather limited.Objectives: We investigated the associations between dietary intake and adipose tissue content of long-chain n-3 PUFAs and subsequent 5-y change in body weight and waist circumference in humans. Effect modification by the carbohydrate:protein ratio and glycemic index was also investigated.Design: A total of 29,152 participants included in the Diet, Cancer, and Health cohort were followed...
March 29, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28343014/natural-lipids-enriched-self-nano-emulsifying-systems-for-effective-co-delivery-of-tamoxifen-and-naringenin-systematic-approach-for-improved-breast-cancer-therapeutics
#4
Premjeet Singh Sandhu, Rajendra Kumar, Sarwar Beg, Sanyog Jain, Varun Kushwah, O P Katare, Bhupinder Singh
The nano-miceller drug delivery carriers of tamoxifen (TMX) having natural ingredients like polyunsaturated fatty acid (PUFA) with self-nano-emulsifying properties was developed with naringenin (NG) in a synergistic manner i.e. TMX-NG-SNEDDS. The optimized nano-formulation revealed complete drug release in 30 min and >80% permeation in 45 min. Superior cellular uptake potential (4.6-6.5-fold) of the TMX-NG-SNEDDS using Caco-2 cells while cytotoxicity study on MCF-7 cells indicated significant results (P<0...
March 23, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28337841/yeast-aquaporin-regulation-by-4-hydroxynonenal-is-implicated-in-oxidative-stress-response
#5
Claudia Rodrigues, Ivana Tartaro Bujak, Branka Mihaljević, Graça Soveral, Ana Cipak Gasparovic
Reactive oxygen species, especially hydrogen peroxide (H2 O2 ), contribute to functional molecular impairment and cellular damage, but also are necessary in normal cellular metabolism, and in low doses play stimulatory role in cell proliferation and stress resistance. In parallel, reactive aldehydes such as 4-hydroxynonenal (HNE), are lipid peroxidation breakdown products which also contribute to regulation of numerous cellular processes. Recently, channeling of H2 O2 by some mammalian aquaporin isoforms has been reported and suggested to contribute to aquaporin involvement in cancer malignancies, although the mechanism by which these membrane water channels are implicated in oxidative stress is not clear...
March 24, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28334272/17%C3%AE-estradiol-induced-acsl4-protein-expression-promotes-an-invasive-phenotype-in-estrogen-receptor-positive-mammary-carcinoma-cells
#6
Anissa Belkaid, Rodney J Ouellette, Marc E Surette
Long chain acyl-CoA synthase-4 (ACSL4) expression has been associated with an aggressive phenotype in breast carcinoma cells, whereas its role in ERα-positive breast cancer has not been studied. ACSL4 prefers 20-carbon polyunsaturated fatty acid (PUFA) substrates, and along with other ACSLs has been associated with cellular uptake of exogenous fatty acids. 17β-estradiol induces proliferation and invasive capacities in ERα+ve breast carcinoma that is associated with modifications of cellular lipid metabolism...
April 1, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28330470/involvement-of-apoptotic-pathways-in-docosahexaenoic-acid-induced-benefit-in-prostate-cancer-pathway-focused-gene-expression-analysis-using-rt-2-profile-pcr-array-system
#7
Yanan Sun, Xiaopeng Jia, Lianguo Hou, Xing Liu, Qiang Gao
BACKGROUND: Present study aimed to better understand the potential apoptotic pathways that involved in docosahexaenoic acid (DHA)-induced apoptosis of prostate cancer cells. METHODS: Human prostate cancer DU145 cells were treated with different concentrations of fish oil, omega-3 PUFA (DHA, and Eicosapentaenoic acid, EPA), or omega-6 PUFA (Arachidonic acid, AA). Cell viability and apoptosis were evaluated by MTT assay and Hoechst staining. Pathway-focused gene expression profiling of DU145 cells was analyzed with the RT(2) Profile PCR Array System...
March 23, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28301979/short-time-uva-exposure-to-human-keratinocytes-instigated-polyunsaturated-fatty-acid-without-inducing-lipid-peroxidation
#8
Kin Sum Leung, Hok Fung Chan, Ho Hang Leung, Jean-Marie Galano, Camille Oger, Thierry Durand, Jetty Chung-Yung Lee
Short-term exposure to ultraviolet A (UVA) radiation can directly injure our skin through inflammatory response and indirectly through oxidative stress, triggering polyunsaturated fatty acid (PUFA) peroxidation in skin cell membrane and formation of DNA adduct, 8-hydroxy-2'-deoxyguanosine (8-OHdG). It is known that UVA exposure leads to photoaging, immunosuppression and skin cancer. However, the changes in PUFA and its oxidized metabolites, and cell cycle after short UVA exposure, are debatable. In this study, human keratinocytes (HaCaT) were exposed to low dose (5 J/cm(2)) and high dose (20 J/cm(2)) of UVA and assessed immediately, 8 h, 12 h, and 24 h post-treatment...
March 17, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28264783/dietary-lipids-differentially-modulate-the-initiation-of-experimental-breast-carcinogenesis-through-their-influence-on-hepatic-xenobiotic-metabolism-and-dna-damage-in-the-mammary-gland
#9
Miguel Ángel Manzanares, Cristina de Miguel, M Carme Ruiz de Villa, Regina M Santella, Eduard Escrich, Montserrat Solanas
Breast cancer is the most common malignancy among women worldwide. In addition to reproductive factors, environmental factors such as nutrition and xenobiotic exposure have a role in the etiology of this malignancy. A stimulating and a potentially protective effect on experimental breast cancer has been previously described for high corn oil and high extra-virgin olive oil diets, respectively. This work investigates the effect of these lipids on the metabolism of 7,12-dimethylbenz(a)anthracene (DMBA), a polycyclic aromatic hydrocarbon that can initiate carcinogenesis and its consequences in an experimental rat breast cancer model...
February 10, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28245562/dietary-%C3%AF-3-polyunsaturated-fatty-acids-inhibit-tumor-growth-in-transgenic-apc-min-mice-correlating-with-cb1-receptor-up-regulation
#10
Maria Notarnicola, Valeria Tutino, Valentina De Nunzio, Francesco Dituri, Maria Gabriella Caruso, Gianluigi Giannelli
Mediterranean diet components, such as olive oil and ω-3 polyunsaturated fatty acids (ω-3 PUFAs), can arrest cell growth and promote cell apoptosis. Recently, olive oil has been demonstrated to modulate type-1 cannabinoid (CB1) receptor gene expression in both human colon cancer cells and rat colon. The aim of this study was to investigate a possible link between olive oil and ω-3 PUFAs effects and CB1 receptor expression in both intestinal and adipose tissue of Apc(Min/+) mice. To confirm the role for the CB1 receptor as a negative modulator of cell proliferation in human colon cancer, CB1 receptor gene expression was also detected in tumor tissue and in surrounding normal mucosa of patients with colorectal cancer (CRC)...
February 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28241486/modulation-of-ras-erk-and-phosphoinositide-signaling-by-long-chain-n-3-pufa-in-breast-cancer-and-their-potential-complementary-role-in-combination-with-targeted-drugs
#11
REVIEW
Simona Serini, Gabriella Calviello
A potential complementary role of the dietary long-chain n-3 polyunsaturated fatty acids (LCn-3 PUFA) in combination with innovative mono-targeted therapies has recently been proposed. These compounds are thought to act pleiotropically to prevent the development and progression of a variety of cancers, including breast cancer. We hereinafter critically analyze the reports investigating the ability of LCn-3 PUFA to modulate the Ras/ERK and the phosphoinositide survival signaling pathways often aberrantly activated in breast cancer and representing the main targets of innovative therapies...
February 23, 2017: Nutrients
https://www.readbyqxmd.com/read/28239063/fatty-acid-and-lipid-class-composition-of-the-microalga-phaeodactylum-tricornutum
#12
Yu-Hong Yang, Lei Du, Masashi Hosokawa, Kazuo Miyashita, Yume Kokubun, Hisayoshi Arai, Hiroyuki Taroda
n-3 Polyunsaturated fatty acids (PUFAs) are essential for the prevention and/or risk reduction of some diseases, including cardiovascular diseases and cancer. Therefore, PUFAs-rich marine microalgae have received considerable research attention. The diatom Phaeodactylum tricornutum, a rich source of lipids and fucoxanthin, has commercial applications in the food and pharmaceutical industries. In this study, the lipid class composition and fatty acid distribution in P. tricornutum under high-density and scale-up cultivation were investigated by thin-layer chromatography and gas chromatography...
February 24, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28236708/comparative-study-on-the-occurrence-of-polycyclic-aromatic-hydrocarbons-in-breast-milk-and-infant-formula-and-risk-assessment
#13
Serena Santonicola, Alessandra De Felice, Luigi Cobellis, Nicola Passariello, Angela Peluso, Nicoletta Murru, Maria Carmela Ferrante, Raffaelina Mercogliano
The study compared the polycyclic aromatic hydrocarbons (PAH) profile of human milk collected from Italian mothers and different brands of infant formula available on Italian market. Levels of 14 PAHs most frequently occurred in food, PAH markers listed by Commission Regulation (EC) No. 1881/2006, and carcinogenic PAHs classified by the International Agency for Research on Cancer, were determined by high-pressure liquid chromatography with fluorescence detector. The average concentrations of total PAHs were 114...
May 2017: Chemosphere
https://www.readbyqxmd.com/read/28109294/probing-the-intermolecular-interactions-of-ppar%C3%AE-lbd-with-polyunsaturated-fatty-acids-and-their-anti-inflammatory-metabolites-to-infer-most-potential-binding-moieties
#14
Shalini Muralikumar, Umashankar Vetrivel, Angayarkanni Narayanasamy, Undurti N Das
BACKGROUND: PPARγ is an isoform of peroxisome proliferator-activated receptor (PPAR) belonging to a super family of nuclear receptors. PPARγ receptor is found to play a crucial role in the modulation of lipid and glucose homeostasis. Its commotion has been reported to play a significant role in a broad spectrum of diseases such as type 2 diabetes mellitus, inflammatory diseases, Alzheimer's disease, and in some cancers. Hence, PPARγ is an important therapeutic target. Polyunsaturated fatty acids (PUFAs) and their metabolites (henceforth referred to as bioactive lipids) are known to function as agonists of PPARγ...
January 21, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28105626/-effect-of-polyunsaturated-fatty-acids-%C3%AF-3-and-%C3%AF-6-on-angiogenesis-formation-in-human-gastric-cancer
#15
Jiachi Ma, Yuntao Ma, Tiankang Guo, Quan Chen, Yiping Li, He Su, Xiaochang Chen, Xiaodan Zhao, Qinjin Guo, Jianbo Qi
OBJECTIVE: To investigate the effects of polyunsaturated fatty acids (PUFA) ω-3 and ω-6, and their middle metabolites PGE2 and PGE3 on angiogenesis formation of gastric cancer, and to explore associated mechanism. METHODS: The effects of ω-3, ω-6, PGE2, PGE3 on the proliferation and migration of human umbilical vein endothelial cell (HUVEC) were measured by proliferation and migration assay respectively. The angiogenesis assay in vivo was used to measure the effects of ω-3, ω-6, PGE2 and PGE3 on neovascularization...
January 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28094560/systemic-metabolite-changes-in-wild-type-c57bl-6-mice-fed-black-raspberries
#16
Pan Pan, Chad W Skaer, Hsin-Tzu Wang, Michael A Kreiser, Steven M Stirdivant, Kiyoko Oshima, Yi-Wen Huang, Matthew R Young, Li-Shu Wang
INTRODUCTION: Freeze-dried black raspberries (BRBs) elicit chemopreventive effects against colorectal cancer in humans and in rodents. The objective of this study was to investigate potential BRB-caused metabolite changes using wild-type (WT) C57BL/6 mice. METHODS AND RESULTS: WT mice were fed either control diet or control diet supplemented with 5% BRBs for 8 wk. A nontargeted metabolomic analysis was conducted on colonic mucosa, liver, and fecal specimens collected from both diet groups...
February 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28003759/omega-3-polyunsaturated-fatty-acids-in-the-prevention-of-postoperative-complications-in-colorectal-cancer-a-meta-analysis
#17
Hai Xie, Yan-Na Chang
OBJECTIVE: To evaluate systematically the clinical efficacy of omega-3 polyunsaturated fatty acids (PUFAs) in the prevention of postoperative complications in colorectal cancer (CRC) patients. MATERIALS AND METHODS: Published articles were identified by using search terms in online databases - PubMed, Embase, and the Cochrane Library - up to March 2016. Only randomized controlled trials investigating the efficacy of omega-3 PUFAs in CRC were selected and analyzed through a meta-analysis...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27990120/polyunsaturated-fatty-acids-and-their-derivatives-therapeutic-value-for-inflammatory-functional-gastrointestinal-disorders-and-colorectal-cancer
#18
REVIEW
Arkadiusz Michalak, Paula Mosińska, Jakub Fichna
Polyunsaturated fatty acids (PUFAs) are bioactive lipids which modulate inflammation and immunity. They gained recognition in nutritional therapy and are recommended dietary supplements. There is a growing body of evidence suggesting the usefulness of PUFAs in active therapy of various gastrointestinal (GI) diseases. In this review we briefly cover the systematics of PUFAs and their metabolites, and elaborate on their possible use in inflammatory bowel disease (IBD), functional gastrointestinal disorders (FGIDs) with focus on irritable bowel syndrome (IBS), and colorectal cancer (CRC)...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27914515/measurement-of-red-blood-cell-eicosapentaenoic-acid-epa-levels-in-a-randomised-trial-of-epa-in-patients-with-colorectal-cancer-liver-metastases
#19
Henry Watson, Andrew J Cockbain, Jade Spencer, Amanda Race, Milene Volpato, Paul M Loadman, Giles J Toogood, Mark A Hull
We investigated red blood cell (RBC) PUFA profiles, and the predictive value of RBC EPA content for tumour EPA exposure and clinical outcomes, in the EMT study, a randomised trial of EPA in patients awaiting colorectal cancer (CRC) liver metastasis surgery (Cockbain et al., 2014) [8]. There was a significant increase in RBC EPA in the EPA group (n=43; median intervention 30 days; mean absolute 1.26[±0.14]% increase; P<0.001), but not in the placebo arm (n=45). EPA incorporation varied widely in EPA users and was not explained by treatment duration or compliance...
December 2016: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/27904556/the-effect-of-%C3%AF-fatty-acids-on-the-expression-of-phospholipase-a2-group-2a-in-human-gastric-cancer-patients
#20
Mahboube Shariati, Mahmoud Aghaei, Ahmad Movahedian, Mohammad Hosein Somi, Homayun Dolatkhah, Ahmad Mirza Aghazade
BACKGROUND: Studies show that polyunsaturated fatty acids (PUFAs) may have an inhibitory role in carcinogenesis. It was previously shown that PLA2 group 2A (PLA2G2A) messenger RNA (mRNA) expression is associated with less frequent metastasis and longer survival in gastric adenocarcinoma. This study intends to investigate the effect of PUFAs on the expression of PLA2G2A in patients with gastric cancer. MATERIALS AND METHODS: Thirty-four patients with gastric cancer (GC) were randomly divided into two groups...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
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