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https://www.readbyqxmd.com/read/29136473/structural-investigation-of-bulk-and-dispersed-inverse-lyotropic-hexagonal-liquid-crystalline-phases-of-eicosapentaenoic-acid-monoglyceride
#1
Anan Yaghmur, Sabah Al-Hosayni, Heinz Amenitsch, Stefan Salentinig
Recent studies demonstrated the potential therapeutic use of newly synthesized omega-3 (ω-3) polyunsaturated fatty acid (PUFA) monoglycerides owing to their beneficial health effects in various disorders including cancer and inflammation diseases. To date, the research was mainly focused on exploring the biological effects of these functional lipids. However, to the best of our knowledge, there is no report on the hydration-mediated self assembly of these lipids that leads to the formation of nanostructures, which are attractive for use as vehicles for the delivery of drugs and functional foods...
November 14, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29101597/randomized-placebo-controlled-pilot-trial-of-omega-3-fatty-acids-for-prevention-of-aromatase-inhibitor-induced-musculoskeletal-pain
#2
Maryam B Lustberg, Tonya S Orchard, Raquel Reinbolt, Rebecca Andridge, Xueliang Pan, Martha Belury, Rachel Cole, Amanda Logan, Rachel Layman, Bhuvaneswari Ramaswamy, Robert Wesolowski, Michael Berger, Elaine Patterson, Charles Loprinzi, Charles L Shapiro, Lisa Yee
PURPOSE: Aromatase inhibitor (AI)-induced joint symptoms negatively impact drug adherence and quality of life in breast cancer survivors. Mechanisms underlying symptoms may include inflammation. It is hypothesized that n - 3 polyunsaturated fatty acids (PUFAs) have anti-inflammatory properties and may reduce symptoms. METHODS: We conducted a randomized, double-blind, placebo-controlled study comparing 4.3 g/day n - 3 PUFA supplements vs placebo for 24 weeks in postmenopausal breast cancer patients starting adjuvant AIs...
November 3, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29096149/protective-properties-of-n-3-fatty-acids-and-implications-in-obesity-associated-breast-cancer
#3
REVIEW
Arwa Al-Jawadi, Hanna Moussa, Latha Ramalingam, Suranganie Dharamawardhane, Lauren Gollahon, Preethi Gunaratne, Rakhshanda Layeequr Rahman, Naima Moustaid-Moussa
Obesity is well documented as a risk factor for developing breast cancer, especially in postmenopausal women. Adipose tissue in the breast under obese conditions induces inflammation by increasing macrophage infiltration and pro-inflammatory cytokines that in turn up-regulates genes and signaling pathways, resulting in increased inflammation, cell proliferation and tumor growth in the breast. Due to their potent anti-inflammatory effects, n-3 polyunsaturated fatty acids (n-3 PUFA) are a promising and safe dietary intervention in reducing breast cancer risk...
October 4, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29095488/antigastric-cancer-bioactive-aurantiochytrium-oil-rich-in-docosahexaenoic-acid-from-media-optimization-to-cancer-cells-cytotoxicity-assessment
#4
Shahryar Shakeri, Neda Amoozyan, Farzaneh Fekrat, Mahmood Maleki
Dietary eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may have a role in contributing to the prevention or inhibition of some malignancies. DHA, the most important polyunsaturated fatty acid (PUFA) in fish and thraustochytrid oils, is known for its anticancer activity. However, antigastric cancer activity of thraustochytrid microbial oil is still unclear. In this investigation, 45 thraustochytrid strains were screened for the production of antigastric cancer oil. Cytotoxicity of 12 thraustochytrid oils was assessed by 3-(4,5-dimethythiazol- 2-yl)-2,5-diphenyl tetrazolium bromide (MTT) on gastric cancer AGS cells...
November 2, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29074485/animal-models-of-chemotherapy-induced-mucositis-translational-relevance-and-challenges
#5
Per T Sangild, René Liang Shen, Peter Erik Lotko Pontoppidan, Mathias Rathe
Chemotherapy for cancer patients induces damaging tissue reactions along the epithelium of the gastrointestinal tract (GIT). This chemotherapy-induced mucositis (CIM) is a serious side effect of cytotoxic drugs and several animal models of CIM have been developed to help understand the progression of CIM, and how to prevent it. Animal models allow highly controlled experimental conditions, detailed organ (e.g. GIT) insights, standardized, clinically-relevant treatment regimens and discovery of new biomarkers...
October 26, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29071721/erythrocyte-membrane-fatty-acids-and-breast-cancer-risk-a-prospective-analysis-in-the-nurses-health-study-ii
#6
Kelly A Hirko, Boyang Chai, Donna Spiegelman, Hannia Campos, Maryam S Farvid, Susan E Hankinson, Walter C Willett, A Heather Eliassen
The roles of specific fatty acids in breast cancer etiology are unclear, particularly among premenopausal women. We examined 34 individual fatty acids, measured in blood erythrocytes collected between 1996-1999, and breast cancer risk in a nested case-control study of primarily premenopausal women in the Nurses' Health Study II. Breast cancer cases diagnosed after blood collection and before June 2010 (n=794) were matched to controls and conditional logistic regression was used to estimate OR's (95% CI's) for associations of fatty acids with breast cancer; unconditional logistic regression was used for stratified analyses...
October 26, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29061780/docosahexaenoic-acid-monoglyceride-increases-carboplatin-activity-in-lung-cancer-models-by-targeting-egfr
#7
Caroline Morin, Samuel Fortin
BACKGROUND/AIM: Omega 3 polyunsaturated fatty acids (PUFAs) have been shown to inhibit the induction and progression of many tumor types. The aim of this study was to determine the anticancer effect of docosahexaenoic acid monoglyceride (MAG-DHA) alone and in combination with the chemotherapeutic agent carboplatin (CBT) on lung cancer models. MATERIALS AND METHODS: Adenocarcinoma cell lines A549 and H1299 were used to evaluate the effect of combined MAG-DHA and CBT treatments both in vitro and in vivo in xenograft models...
November 2017: Anticancer Research
https://www.readbyqxmd.com/read/29052029/migration-and-invasion-induced-by-linoleic-acid-are-mediated-through-fascin-in-mda-mb-231-breast-cancer-cells
#8
Christian Gonzalez-Reyes, Cleofas Marcial-Medina, Nancy Cervantes-Anaya, Pedro Cortes-Reynosa, Eduardo Perez Salazar
Epidemiological studies strongly suggest an association between high levels of dietary fat intake and an increased risk of developing breast cancer. Linoleic acid (LA) is an essential omega-6 PUFA and the major fatty acid in occidental diets. In breast cancer cells, LA induces expression of plasminogen activator inhibitor-1, proliferation, migration, and invasion. Fascin is an actin crosslinker globular protein that generates actin bundles made of parallel actin filaments, which mediate formation and stability of microspikes, stress fibers, membrane ruffles, and filopodia...
October 19, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29030414/longitudinal-associations-between-marine-omega-3-supplement-users-and-coronary-heart-disease-in-a-uk-population-based-cohort
#9
Marleen A H Lentjes, Ruth H Keogh, Ailsa A Welch, Angela A Mulligan, Robert N Luben, Nicholas J Wareham, Kay-Tee Khaw
OBJECTIVES: Assess the association between marine omega-3 polyunsaturated fatty acid (n-3 PUFA) intake from supplements, mainly cod liver oil, and coronary heart disease (CHD) mortality. DESIGN: Prospective cohort study, with three exposure measurements over 22 years. SETTING: Norfolk-based European Prospective Investigation into Cancer (EPIC-Norfolk, UK). PARTICIPANTS: 22 035 men and women from the general population, 39-79 years at recruitment...
October 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28986132/new-perspectives-in-cancer-modulation-of-lipid-metabolism-and-inflammation-resolution
#10
REVIEW
Nella Prevete, Federica Liotti, Angela Amoresano, Piero Pucci, Amato de Paulis, Rosa Marina Melillo
Inflammation is considered an enabling feature of cancer. Besides the persistence of inflammatory stimuli, also defective mechanisms of resolution can lead to chronic inflammation. Inflammation resolution is an active process controlled by lipidic specialized pro-resolving mediators (SPMs), derived from ω-3 or ω-6 essential polyunsaturated fatty acids (PUFA) through the activity of lipoxygenases (ALOX5 and 15). Thus, a lack or defect in resolution mechanisms may affect cancer development and progression by prolonging inflammation...
October 3, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28980737/gpr120-is-not-required-for-%C3%AF-3-pufas-induced-cell-growth-inhibition-and-apoptosis-in-breast-cancer-cells
#11
Shenglong Zhu, Xiaowei Jiang, Siyuan Jiang, Guangxiao Lin, Jianping Gong, Wei Chen, Zhao He, Yong Q Chen
Intake of ω-3 PUFAs reduces the frequency of breast cancer, and GPR120 receptor transduces ω-3 PUFAs signaling to increase insulin sensitivity in mice, but whether GPR120 mediates ω-3 PUFAs signaling to inhibit breast carcinogenesis is currently unknown. In the present study, we found that GPR120 is highly expressed in human breast cancerous tissues but not adjacent normal tissue. Knockdown of GPR120 by siRNA in breast cancer cells significantly reduced cell growth, and dramatically increased ω-3 FFA-induced cell growth inhibition and apoptosis...
October 5, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28968813/metabolome-wide-association-study-identified-the-association-between-a-circulating-polyunsaturated-fatty-acids-variant-rs174548-and-lung-cancer
#12
Cheng Wang, Na Qin, Meng Zhu, Minjian Chen, Kaipeng Xie, Yang Cheng, Juncheng Dai, Jia Liu, Yankai Xia, Hongxia Ma, Guangfu Jin, Christopher I Amos, Zhibin Hu, Dongxin Lin, Hongbing Shen
Quantitative trait loci (QTLs) are widely used as instruments to infer causal risk factors of diseases based on the idea of mendelian randomization. Plasma metabolites can serve as risk factors of cancer, and the heritability of many circulating metabolites was high. We conducted a metabolome-wide association study (MWAS) to systematically investigate the effects of genetic variants on metabolites and lung cancer based on published genome-wide association study (GWASs) and metabolic-QTL (mQTL) study. Then we confirmed the results by subsequent genetic and metabolic validations and inferred the causal relationship between identified metabolites and lung cancer through genetic variant(s)...
October 26, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28951525/a-randomised-trial-of-the-effect-of-omega-3-polyunsaturated-fatty-acid-supplements-on-the-human-intestinal-microbiota
#13
Henry Watson, Suparna Mitra, Fiona C Croden, Morag Taylor, Henry M Wood, Sarah L Perry, Jade A Spencer, Phil Quirke, Giles J Toogood, Clare L Lawton, Louise Dye, Paul M Loadman, Mark A Hull
OBJECTIVE: Omega-3 polyunsaturated fatty acids (PUFAs) have anticolorectal cancer (CRC) activity. The intestinal microbiota has been implicated in colorectal carcinogenesis. Dietary omega-3 PUFAs alter the mouse intestinal microbiome compatible with antineoplastic activity. Therefore, we investigated the effect of omega-3 PUFA supplements on the faecal microbiome in middle-aged, healthy volunteers (n=22). DESIGN: A randomised, open-label, cross-over trial of 8 weeks' treatment with 4 g mixed eicosapentaenoic acid/docosahexaenoic acid in two formulations (soft-gel capsules and Smartfish drinks), separated by a 12-week 'washout' period...
September 26, 2017: Gut
https://www.readbyqxmd.com/read/28949340/dietary-fish-n-3-polyunsaturated-fatty-acid-consumption-and-depression-risk-in-japan-a-population-based-prospective-cohort-study
#14
Y J Matsuoka, N Sawada, M Mimura, R Shikimoto, S Nozaki, K Hamazaki, Y Uchitomi, S Tsugane
Systematic review of observational studies has revealed that fish consumption and levels of n-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid are associated with a reduced risk of depression. A reverse J-shaped effect of n-3 PUFAs was suggested. However, there is limited evidence from populations with high fish consumption and no studies have used a standard psychiatrist-based diagnosis of major depressive disorder (MDD). Therefore, this population-based, prospective study investigated the association of dietary fish, n-3 PUFA, and n-6 PUFA consumption with risk of psychiatrist-diagnosed MDD in Japan...
September 26, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28937788/lipid-extracts-from-the-brains-of-silver-carp-hypophthalmichthys-molitrix-induce-apoptosis-in-mcf-7-cells-through-the-generation-of-reactive-oxygen-species-and-the-mitochondrial-pathway
#15
Caixia Wang, Wenshui Xia, Qixing Jiang, Yanshun Xu, Peipei Yu
Previous studies have verified the protective role of n3 polyunsaturated fatty acids (PUFAs) in cancer. Fish brain lipids are rich in n3 PUFAs. However, the action and mechanism of their potent anticancer activities remain unclear. In this study, polar lipids (PLs) and neutral lipids (NLs) were isolated from the total lipids (TLs) of the silver carp brain, and the anticancer effects of the lipid fractions (LFs) were examined in a human breast cancer cell line (MCF-7). The LFs effectively inhibited the cell proliferation of MCF-7 cells in a time- and concentration-dependent manner by cell cycle arrest at the S stage and induction of apoptosis...
September 22, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28894242/complementary-acsl-isoforms-contribute-to-a-non-warburg-advantageous-energetic-status-characterizing-invasive-colon-cancer-cells
#16
Ruth Sánchez-Martínez, Silvia Cruz-Gil, María Soledad García-Álvarez, Guillermo Reglero, Ana Ramírez de Molina
Metabolic reprogramming is one of cancer hallmarks. Here, we focus on functional differences and individual contribution of acyl coA synthetases (ACSL) isoforms to the previously described ACSL/stearoyl-CoA desaturase (ACSL1/ACSL4/SCD) metabolic network causing invasion and poor prognosis in colorectal cancer (CRC). ACSL4 fuels proliferation and migration accompanied by a more glycolytic phenotype. Conversely, ACSL1 stimulates invasion displaying a lower basal respiratory rate. Acylcarnitines elevation, polyunsaturated fatty acids (PUFA) lower levels, and monounsaturated fatty acids (MUFA) upregulation characterize the individual overexpression of ACSL1, ACSL4 and SCD, respectively...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28891336/polyunsaturated-fatty-acid-based-targeted-nanotherapeutics-to-enhance-the-therapeutic-efficacy-of-docetaxel
#17
Thiruganesh Ramasamy, Pasupathi Sundaramoorthy, Hima Bindu Ruttala, Yongjoo Choi, Woo Hyun Shin, Jee-Heon Jeong, Sae Kwang Ku, Han-Gon Choi, Hwan Mook Kim, Chul Soon Yong, Jong Oh Kim
Since breast cancer is one of the most lethal malignancies, targeted strategies are urgently needed. In this study, we report the enhanced therapeutic efficacy of docetaxel (DTX) when combined with polyunsaturated fatty acids (PUFA) for effective treatment of multi-resistant breast cancers. Folic acid (FA)-conjugated PUFA-based lipid nanoparticles (FA-PLN/DTX) was developed. The physicochemical properties, in vitro uptake, in vitro cytotoxicity, and in vivo anticancer activity of FA-PLN/DTX were evaluated. FA-PLN/DTX could efficiently target and treat human breast tumor xenografts in vivo...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28882592/polyunsaturated-fatty-acids-induce-ovarian-cancer-cell-death-through-ros-dependent-map-kinase-activation
#18
Aiko Tanaka, Akane Yamamoto, Kaeko Murota, Toshifumi Tsujiuchi, Masao Iwamori, Nobuyuki Fukushima
Free fatty acids not only play a role in cell membrane construction and energy production but also exert diverse cellular effects through receptor and non-receptor mechanisms. Moreover, epidemiological and clinical studies have so far suggested that polyunsaturated fatty acids (PUFAs) could have health benefits and the advantage as therapeutic use in cancer treatment. However, the underlying mechanisms of PUFA-induced cellular effects remained to be cleared. Here, we examined the effects of ω-3 and ω-6 PUFAs on cell death in ovarian cancer cell lines...
November 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28843558/targeted-quantification-of-lipid-mediators-in-skeletal-muscles-using-restricted-access-media-based-trap-and-elute-liquid-chromatography-mass-spectrometry
#19
Zhiying Wang, Liangqiao Bian, Chenglin Mo, Maciej Kukula, Kevin A Schug, Marco Brotto
Lipid mediators (LMs) are a class of bioactive metabolites of the essential polyunsaturated fatty acids (PUFA), which are involved in many physiological processes. Their quantification in biological samples is critical for understanding their functions in lifestyle and chronic diseases, such as diabetes, as well allergies, cancers, and in aging processes. We developed a rapid, and sensitive LC-MS/MS method to quantify the concentrations of 14 lipid mediators of interest in mouse skeletal muscle tissue without time-consuming liquid-liquid or solid-phase extractions...
September 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28829991/pro-inflammatory-fatty-acid-profile-and-colorectal-cancer-risk-a-mendelian-randomisation-analysis
#20
Sebastian May-Wilson, Amit Sud, Philip J Law, Kimmo Palin, Sari Tuupanen, Alexandra Gylfe, Ulrika A Hänninen, Tatiana Cajuso, Tomas Tanskanen, Johanna Kondelin, Eevi Kaasinen, Antti-Pekka Sarin, Johan G Eriksson, Harri Rissanen, Paul Knekt, Eero Pukkala, Pekka Jousilahti, Veikko Salomaa, Samuli Ripatti, Aarno Palotie, Laura Renkonen-Sinisalo, Anna Lepistö, Jan Böhm, Jukka-Pekka Mecklin, Nada A Al-Tassan, Claire Palles, Susan M Farrington, Maria N Timofeeva, Brian F Meyer, Salma M Wakil, Harry Campbell, Christopher G Smith, Shelley Idziaszczyk, Timothy S Maughan, David Fisher, Rachel Kerr, David Kerr, Michael N Passarelli, Jane C Figueiredo, Daniel D Buchanan, Aung K Win, John L Hopper, Mark A Jenkins, Noralane M Lindor, Polly A Newcomb, Steven Gallinger, David Conti, Fred Schumacher, Graham Casey, Lauri A Aaltonen, Jeremy P Cheadle, Ian P Tomlinson, Malcolm G Dunlop, Richard S Houlston
BACKGROUND: While dietary fat has been established as a risk factor for colorectal cancer (CRC), associations between fatty acids (FAs) and CRC have been inconsistent. Using Mendelian randomisation (MR), we sought to evaluate associations between polyunsaturated (PUFA), monounsaturated (MUFA) and saturated FAs (SFAs) and CRC risk. METHODS: We analysed genotype data on 9254 CRC cases and 18,386 controls of European ancestry. Externally weighted polygenic risk scores were generated and used to evaluate associations with CRC per one standard deviation increase in genetically defined plasma FA levels...
October 2017: European Journal of Cancer
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