keyword
MENU ▼
Read by QxMD icon Read
search

pufa, cancer

keyword
https://www.readbyqxmd.com/read/29769200/long-chain-n-3-fatty-acids-attenuate-oncogenic-kras-driven-proliferation-by-altering-plasma-membrane-nanoscale-proteolipid-composition
#1
Natividad R Fuentes, Mohamed Mlih, Rola Barhoumi, Yang-Yi Fan, Paul Hardin, Trevor J Steele, Spencer Behmer, Ian A Prior, Jason Karpac, Robert S Chapkin
Ras signaling originates from transient nanoscale compartmentalized regions of the plasma membrane composed of specific proteins and lipids. The highly specific lipid composition of these nanodomains, termed nanoclusters, facilitates effector recruitment and therefore influences signal transduction. This suggests that Ras nanocluster proteolipid composition could represent a novel target for future chemoprevention interventions. There is evidence that consumption of fish oil containing long-chain n-3 polyunsaturated fatty acids (n-3 PUFA) such as eicosapentaenoic acid (EPA, 20:5Δ5,8,11,14,17) and docosahexaenoic acid (DHA, 22:6Δ4,7,10,13,16,19) may reduce colon cancer risk in humans, yet the mechanism underlying this effect is unknown...
May 16, 2018: Cancer Research
https://www.readbyqxmd.com/read/29749015/usual-energy-and-macronutrient-intakes-in-a-large-sample-of-iranian-middle-aged-and-elderly-populations
#2
Zahra Heidari, Awat Feizi, Leila Azadbakht, Noushin Mohammadifard, Maryam Maghroun, Nizal Sarrafzadegan
AIM: The present study aimed to assess the usual distribution of energy and macronutrient intake among a large representative sample of Iranian healthy middle-aged and elderly people. METHODS: In this cross-sectional study, a second follow-up survey of the Isfahan Cohort Study (ICS) was carried out; 1922 people aged 40 years and older were investigated. Dietary intakes were collected using 24-hour recall and two or more consecutive food records. Distribution of energy and macronutrient intake was estimated using traditional and National Cancer Institute (NCI) methods...
May 10, 2018: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/29715470/omega-3-and-omega-6-polyunsaturated-fatty-acids-dietary-sources-metabolism-and-significance-a-review
#3
REVIEW
Ramesh Kumar Saini, Young-Soo Keum
Linoleic acid (LA) (n-6) and α-linolenic acid (ALA) (n-3) are essential fatty acids (EFAs) as they cannot be synthesized by humans or other higher animals. In the human body, these fatty acids (FAs) give rise to arachidonic acid (ARA, n-6), eicosapentaenoic acid (EPA, n-3), and docosahexaenoic acid (DHA, n-3) that play key roles in regulating body homeostasis. Locally acting bioactive signaling lipids called eicosanoids derived from these FAs also regulate diverse homeostatic processes. In general, ARA gives rise to pro-inflammatory eicosanoids whereas EPA and DHA give rise to anti-inflammatory eicosanoids...
April 28, 2018: Life Sciences
https://www.readbyqxmd.com/read/29708079/barriers-to-cancer-nutrition-therapy-excess-catabolism-of-muscle-and-adipose-tissues-induced-by-tumour-products-and-chemotherapy
#4
Dalton L Schiessel, Vickie E Baracos
Cancer-associated malnutrition is driven by reduced dietary intake and by underlying metabolic changes (such as inflammation, anabolic resistance, proteolysis, lipolysis and futile cycling) induced by the tumour and activated immune cells. Cytotoxic and targeted chemotherapies also elicit proteolysis and lipolysis at the tissue level. In this review, we summarise specific mediators and chemotherapy effects that provoke excess proteolysis in muscle and excess lipolysis in adipose tissue. A nutritionally relevant question is whether and to what degree these catabolic changes can be reversed by nutritional therapy...
April 30, 2018: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/29668624/effect-of-%C3%AF-3-polyunsaturated-fatty-acid-supplemented-parenteral-nutrition-on-inflammatory-and-immune-function-in-postoperative-patients-with-gastrointestinal-malignancy-a-meta-analysis-of-randomized-control-trials-in-china
#5
Yajie Zhao, Chengfeng Wang
BACKGROUND: There are no consensus regarding the efficacy of omega-3polyunsaturated fatty acids (PUFAs) on inflammatory and immune function in postoperative patients with gastrointestinal malignancy. METHODS: The literatures published randomized control trials (RCT) were searched in PubMed, Embase, Scopus, Cochrane Library, CNKI, Weipu, and Wanfang Databases. The immune efficacy outcomes of ω-3 polyunsaturated fatty acid-supplemented parenteral nutrition in patients with gastrointestinal malignancy were compared...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29659013/dietary-fat-and-fiber-interact-to-uniquely-modify-global-histone-post-translational-epigenetic-programming-in-a-rat-colon-cancer-progression-model
#6
Karen Triff, Mathew W McLean, Evelyn Callaway, Jennifer Goldsby, Ivan Ivanov, Robert S Chapkin
Dietary fermentable fiber generates short-chain fatty acids (SCFA), e.g., butyrate, in the colonic lumen which serves as a chemoprotective histone deacetylase inhibitor and/or as an acetylation substrate for histone acetylases. In addition, n-3 polyunsaturated fatty acids (n-3 PUFA) in fish oil can affect the chromatin landscape by acting as ligands for tumor suppressive nuclear receptors. In an effort to gain insight into the global dimension of post-translational modification of histones (including H3K4me3 and H3K9ac) and clarify the chemoprotective impact of dietary bioactive compounds on transcriptional control in a preclinical model of colon cancer, we generated high-resolution genome-wide RNA (RNA-Seq) and "chromatin-state" (H3K4me3-seq and H3K9ac-seq) maps for intestinal (epithelial colonocytes) crypts in rats treated with a colon carcinogen and fed diets containing bioactive (i) fish oil, (ii) fermentable fiber (a rich source of SCFA), (iii) a combination of fish oil plus pectin or (iv) control, devoid of fish oil or pectin...
April 16, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29628046/mechanisms-underlying-the-effects-of-n-3-polyunsaturated-fatty-acids-on-fear-memory-processing-and-their-hypothetical-effects-on-fear-of-cancer-recurrence-in-cancer-survivors
#7
REVIEW
R Okubo, C Chen, M Sekiguchi, K Hamazaki, Y J Matsuoka
The relationship of n-3 polyunsaturated fatty acids (PUFAs) and gut microbiota with brain function has been extensively reported. Here, we review how n-3 polyunsaturated fatty acids affect fear memory processing. n-3 PUFAs may improve dysfunctional fear memory processing via immunomodulation/anti-inflammation, increased BDNF, upregulated adult neurogenesis, modulated signal transduction, and microbiota-gut-brain axis normalization. We emphasize how n-3 PUFAs affect this axis and also focus on the hypothetical effects of PUFAs in fear of cancer recurrence (FCR), the primary psychological unmet need of cancer survivors...
April 2018: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29627343/omega-3-fatty-acids-membrane-remodeling-and-cancer-prevention
#8
REVIEW
Natividad R Fuentes, Eunjoo Kim, Yang-Yi Fan, Robert S Chapkin
Proteins are often credited as the macromolecule responsible for performing critical cellular functions, however lipids have recently garnered more attention as our understanding of their role in cell function and human health becomes more apparent. Although cellular membranes are the lipid environment in which many proteins function, it is now apparent that protein and lipid assemblies can be organized to form distinct micro- or nanodomains that facilitate signaling events. Indeed, it is now appreciated that cellular function is partly regulated by the specific spatiotemporal lipid composition of the membrane, down to the nanosecond and nanometer scale...
April 5, 2018: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/29616321/saturated-mono-and-polyunsaturated-fatty-acid-intake-and-cancer-risk-results-from-the-french-prospective-cohort-nutrinet-sant%C3%A3
#9
Laury Sellem, Bernard Srour, Françoise Guéraud, Fabrice Pierre, Emmanuelle Kesse-Guyot, Thibault Fiolet, Céline Lavalette, Manon Egnell, Paule Latino-Martel, Philippine Fassier, Serge Hercberg, Pilar Galan, Mélanie Deschasaux, Mathilde Touvier
PURPOSE: Lipid intakes such as saturated (SFA), monounsaturated (MUFA) and polyunsaturated (PUFA) fatty acids have been widely studied regarding cardiovascular health, but their relevance to cancer is unclear. Inconsistent epidemiological results may be explained by varied mechanisms involving PUFAs and redox balance, inflammatory status and cell signalling, along with interactions with other dietary components such as antioxidants, dietary fibre and more generally fruits and vegetable intakes...
April 3, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29570667/differential-tissue-fatty-acids-profiling-between-colorectal-cancer-patients-with-and-without-synchronous-metastasis
#10
Maria Notarnicola, Dionigi Lorusso, Valeria Tutino, Valentina De Nunzio, Giampiero De Leonardis, Gisella Marangelli, Vito Guerra, Nicola Veronese, Maria Gabriella Caruso, Gianluigi Giannelli
The early detection of colorectal cancer and determination of its metastatic potential are important factors to set up more efficacious therapeutic strategies. In the present study, we hypothesize that fatty acids analysis in colorectal cancer patients can discriminate between metastatic and non-metastatic patients. Fifty-one consecutive patients with histologically proven colorectal cancer were enrolled in the study and the presence of synchronous metastasis was detected in 25 of these 51 patients. Fatty acid profile analysis in red blood cell membranes was not able to discriminate the metastatic colorectal cancer patients from those without metastasis...
March 23, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29566193/serum-n-6-polyunsaturated-fatty-acids-and-risk-of-death-the-kuopio-ischaemic-heart-disease-risk-factor-study
#11
Jyrki K Virtanen, Jason H Y Wu, Sari Voutilainen, Jaakko Mursu, Tomi-Pekka Tuomainen
Background: The cardioprotective properties of linoleic acid (LA), a major n-6 (ω-6) polyunsaturated fatty acid (PUFA), have been recognized, but less is known about its associations with other causes of death. Relatively little is also known about how the minor n-6 PUFAs-γ-linolenic acid (GLA), dihomo-γ-linolenic acid (DGLA), and arachidonic acid (AA)-relate to mortality risk. Objective: We investigated the associations of serum n-6 PUFAs, an objective biomarker of exposure, with risk of death in middle-aged and older men and whether disease history modifies the associations...
March 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29545942/effects-of-the-polyunsaturated-fatty-acids-epa-and-dha-on-hematological-malignancies-a-systematic-review
#12
REVIEW
Milad Moloudizargari, Esmaeil Mortaz, Mohammad Hossein Asghari, Ian M Adcock, Frank A Redegeld, Johan Garssen
Omega-3 polyunsaturated fatty acids (PUFAs) have well established anti-cancer properties. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are among this biologically active family of macromolecules for which various anti-cancer effects have been explained. These PUFAs have a high safety profile and can induce apoptosis and inhibit growth of cancer cells both in vitro and in vivo , following a partially selective manner. They also increase the efficacy of chemotherapeutic agents by increasing the sensitivity of different cell lines to specific anti-neoplastic drugs...
February 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29510220/modulation-of-key-lipid-raft-constituents-in-primary-rat-hepatocytes-by-fumonisin-b-1-implications-for-cancer-promotion-in-the-liver
#13
H-M Burger, S Abel, W C A Gelderblom
Fumonisin B1 (FB1 ), a group 2B natural occurring carcinogenic mycotoxin, modulated lipid and fatty acid (FA) constituents of lipid rafts isolated from primary hepatocytes following exposure to a cytotoxic concentration of FB1 (250 μM). The major effects observed in rafts, included a significant (p < 0.05) increase in raft cholesterol (CHOL) and glycerophospholipid such as phosphatidylethanolamine (PE), whereas sphingomyelin (SM) decreased (p < 0.05). Changes in lipid constituents resulted in the disruption of important membrane fluidity parameters represented as a decreased (p < 0...
May 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29491470/dietary-n-3-and-n-6-polyunsaturated-fatty-acids-the-fads-gene-and-the-risk-of-gastric-cancer-in-a-korean-population
#14
Sunghee Lee, Jeonghee Lee, Il Ju Choi, Young-Woo Kim, Keun Won Ryu, Young-Il Kim, Jeongseon Kim
n-3 polyunsaturated fatty acids (PUFAs) and n-6 PUFAs are reported to have immunomodulatory effects, but few studies have examined these functions. Thus, we examined whether dietary n-3 and n-6 PUFAs are associated with the risk of gastric cancer and further investigated whether fatty acid desaturases 1 and 2 (FADS1 and FADS2) modify this association. In a case-control study, 1,464 participants (402 cases and 1,062 controls) were enrolled. A semi-quantitative food frequency questionnaire was utilized to measure dietary PUFA intake...
February 28, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29477476/the-impact-of-polyunsaturated-fatty-acids-on-dna-methylation-and-expression-of-dnmts-in-human-colorectal-cancer-cells
#15
Mostafa Moradi Sarabi, Fakhraddin Naghibalhossaini
Growing evidence suggests a role of polyunsaturated fatty acids (PUFA) in the prevention of various types of malignancy, including colorectal cancer (CRC). No published studies have yet examined the direct effect of PUFA treatment on DNA methylation in CRC cells. In this study, 5 human CRC cells were treated with 100 μM DHA, EPA, and LA for 6 days and changes in their global- and gene-specific DNA methylation status as well as expression of DNA methyl transferases (DNMT) were investigated. Cell-type specific differences in DNA methylation and expression of DNMTs were observed in PUFA-treated cells...
May 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29473154/polyunsaturated-fatty-acids-and-risk-of-melanoma-a-mendelian-randomisation-analysis
#16
Upekha E Liyanage, Matthew H Law, Jue Sheng Ong, Anne E Cust, Graham J Mann, Sarah V Ward, Puya Gharahkhani, Mark M Iles, Stuart MacGregor
Melanoma is the deadliest form of skin cancer, mainly affecting populations of European ancestry. Some observational studies suggest that particular diets reduce melanoma risk, putatively through an increase in polyunsaturated fatty acid (PUFA) consumption. However, interpretation of these observational findings is difficult due to residual confounding or reverse causality. To date, a randomized controlled trial has not been carried out to examine the relationship between PUFAs and melanoma. Hence, we performed a Mendelian randomisation (MR) study to evaluate the link between PUFAs and melanoma...
February 22, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29462928/omega-3-pufa-loaded-in-resveratrol-based-solid-lipid-nanoparticles-physicochemical-properties-and-antineoplastic-activities-in-human-colorectal-cancer-cells-in-vitro
#17
Simona Serini, Roberta Cassano, Paola Antonia Corsetto, Angela Maria Rizzo, Gabriella Calviello, Sonia Trombino
New strategies are being investigated to ameliorate the efficacy and reduce the toxicity of the drugs currently used in colorectal cancer (CRC), one of the most common malignancies in the Western world. Data have been accumulated demonstrating that the antineoplastic therapies with either conventional or single-targeted drugs could take advantage from a combined treatment with omega-3 polyunsaturated fatty acids (omega-3 PUFA). These nutrients, shown to be safe at the dosage generally used in human trials, are able to modulate molecules involved in colon cancer cell growth and survival...
February 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29436473/high-erythrocyte-levels-of-the-n-6-polyunsaturated-fatty-acid-linoleic-acid-are-associated-with-lower-risk-of-subsequent-rheumatoid-arthritis-in-a-southern-european-nested-case-control-study
#18
Paola de Pablo, Dora Romaguera, Helena L Fisk, Philip C Calder, Anne-Marie Quirke, Alison J Cartwright, Salvatore Panico, Amalia Mattiello, Diana Gavrila, Carman Navarro, Carlotta Sacerdote, Paolo Vineis, Rosario Tumino, William E Ollier, Dominique S Michaud, Elio Riboli, Patrick J Venables, Benjamin A Fisher
OBJECTIVES: Findings relating to dietary intake of n-3 polyunsaturated fatty acids (PUFA) and risk of rheumatoid arthritis (RA) are mixed. Erythrocyte membrane PUFA is an accurate objective biomarker of PUFA status; however, there are little data on erythrocyte membrane PUFA and risk of RA. The objective was therefore to compare erythrocyte membrane PUFA between pre-RA individuals and matched controls from a population-based sample, and specifically to test the hypothesis that higher levels of longer chain n-3 PUFA are associated with lower risk of RA...
February 7, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29434704/implications-of-dietary-%C3%AF-3-and-%C3%AF-6-polyunsaturated-fatty-acids-in-breast-cancer
#19
Oana Zanoaga, Ancuta Jurj, Lajos Raduly, Roxana Cojocneanu-Petric, Enrique Fuentes-Mattei, Oscar Wu, Cornelia Braicu, Claudia Diana Gherman, Ioana Berindan-Neagoe
Breast cancer represents one of the most common forms of cancer in women worldwide, with an increase in the number of newly diagnosed patients in the last decade. The role of fatty acids, particularly of a diet rich in ω-3 and ω-6 polyunsaturated fatty acids (PUFAs), in breast cancer development is not fully understood and remains controversial due to their complex mechanism of action. However, a large number of animal models and cell culture studies have demonstrated that high levels of ω-3 PUFAs have an inhibitory role in the development and progression of breast cancer, compared to ω-6 PUFAs...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29433780/nutritional-enhancement-of-sheep-meat-fatty-acid-profile-for-human-health-and-wellbeing
#20
Obert C Chikwanha, Payam Vahmani, Voster Muchenje, Michael E R Dugan, Cletos Mapiye
Dietary fatty acids (FA) consumed by sheep, like other ruminants, can undergo biohydrogenation resulting in high proportions of saturated FA (SFA) in meat. Biohydrogenation is typically less extensive in sheep than cattle, and consequently, sheep meat can contain higher proportions of omega (n)-3 polyunsaturated FA (PUFA), and PUFA biohydrogenation intermediates (PUFA-BHI) including conjugated linoleic acid (CLA) and trans-monounsaturated FAs (t-MUFA). Sheep meat is also noted for having characteristically higher contents of branched chain FA (BCFA)...
February 2018: Food Research International
keyword
keyword
76813
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"