keyword
https://read.qxmd.com/read/38045570/simvastatin-hydrogel-loaded-3d-printed-titanium-alloy-scaffolds-suppress-osteosarcoma-via-tf-nox2-associated-ferroptosis-while-repairing-bone-defects
#21
JOURNAL ARTICLE
Zehao Jing, Wanqiong Yuan, Jiedong Wang, Renhua Ni, Yu Qin, Zhinan Mao, Feng Wei, Chunli Song, Yufeng Zheng, Hong Cai, Zhongjun Liu
Postoperative anatomical reconstruction and prevention of local recurrence after tumor resection are two vital clinical challenges in osteosarcoma treatment. A three-dimensional (3D)-printed porous Ti6Al4V scaffold (3DTi) is an ideal material for reconstructing critical bone defects with numerous advantages over traditional implants, including a lower elasticity modulus, stronger bone-implant interlock, and larger drug-loading space. Simvastatin is a multitarget drug with anti-tumor and osteogenic potential; however, its efficiency is unsatisfactory when delivered systematically...
March 2024: Bioactive Materials
https://read.qxmd.com/read/38044628/toward-comprehensive-analysis-of-the-3d-chemistry-of-pseudomonas-aeruginosa-biofilms
#22
JOURNAL ARTICLE
Anna M Kotowska, Junting Zhang, Alessandro Carabelli, Julie Watts, Jonathan W Aylott, Ian S Gilmore, Paul Williams, David J Scurr, Morgan R Alexander
Bacterial biofilms are structured communities consisting of cells enmeshed in a self-generated extracellular matrix usually attached to a surface. They contain diverse classes of molecules including polysaccharides, lipids, proteins, nucleic acids, and diverse small organic molecules (primary and secondary metabolites) which are organized to optimize survival and facilitate dispersal to new colonization sites. In situ characterization of the chemical composition and structure of bacterial biofilms is necessary to fully understand their development on surfaces relevant to biofouling in health, industry, and the environment...
December 3, 2023: Analytical Chemistry
https://read.qxmd.com/read/38025159/relationship-between-retinal-layer-thickness-and-genetic-susceptibility-to-age-related-macular-degeneration-in-asian-populations
#23
JOURNAL ARTICLE
Kai Xiong Cheong, Hengtong Li, Yih Chung Tham, Kelvin Yi Chong Teo, Anna Cheng Sim Tan, Leopold Schmetterer, Tien Yin Wong, Chui Ming Gemmy Cheung, Ching-Yu Cheng, Qiao Fan
PURPOSE: For OCT retinal thickness measurements to be used as a prodromal age-related macular degeneration (AMD) risk marker, the 3-dimensional (3D) topographic variation of the relationship between genetic susceptibility to AMD and retinal thickness needs to be assessed. We aimed to evaluate individual retinal layer thickness changes and topography at the macula that are associated with AMD genetic susceptibility. DESIGN: Genetic association study. PARTICIPANTS: A total of 1579 healthy participants (782 Chinese, 353 Malays, and 444 Indians) from the multiethnic Singapore Epidemiology of Eye Diseases study were included...
December 2023: Ophthalmol Sci
https://read.qxmd.com/read/38021136/3d-structured-illumination-microscope-using-a-spinning-disk-invited
#24
JOURNAL ARTICLE
Youchang Zhang, Parisa Asghari, David R L Scriven, Edwin D W Moore, Keng C Chou
Three-dimensional (3D) structured illumination microscopy (SIM) improves spatial resolution by a factor of two in both lateral and axial directions. However, the adoption of 3D SIM is limited by low imaging speed, susceptibility to out-of-focus light, and likelihood of reconstruction errors. Here we present a novel approach for 3D SIM using a spinning disk. The disk generates a 3D lattice illumination pattern on the sample and optically reconstructs super-resolved images in real time. This technique achieves a 2-times resolution improvement with a speed up to 100 frames per second while physically rejecting 90% of the background signal...
November 1, 2023: Biomedical Optics Express
https://read.qxmd.com/read/38019793/orthodontic-treatment-using-directly-3d-printed-clear-aligners
#25
JOURNAL ARTICLE
Miyoung Sim, Sungwon Park
No abstract text is available yet for this article.
October 2023: Journal of Clinical Orthodontics: JCO
https://read.qxmd.com/read/38017806/management-of-the-axial-modulation-of-the-illumination-pattern-in-structured-illumination-microscopy-using-an-extended-illumination-source
#26
JOURNAL ARTICLE
Alejandro Gimeno-Gomez, Seyedeh Parisa Dajkhosh, Cong Tuan Son Van, Juan Carlos Barreiro, Chrysanthe Preza, Genaro Saavedra
We have designed and implemented an approach for three-dimensional (3D) structured illumination (SI) microscopy (SIM) based on a quasi-monochromatic extended source illuminating a Wollaston prism to improve robustness, light efficiency and flexibility over our previous design. We show through analytical and experimental verification of the presented theoretical framework for our proposed tunable structured illumination microscopy (TSIM) system, that a simple and accurate determination of the axial modulation of the SI pattern is achieved, enabling a realistic characterization of the system's effective optical transfer function (OTF)...
October 23, 2023: Optics Express
https://read.qxmd.com/read/37896299/analysis-of-mechanical-properties-and-structural-analysis-according-to-the-multi-layered-structure-of-polyethylene-based-self-reinforced-composites
#27
JOURNAL ARTICLE
Seonghun Yu, Junhee Lee, Jongkyu Kim, Hojong Chang, Chansol Kang, Jeehyun Sim
In this research, a self-reinforced composite material was manufactured using a single polyethylene material, and this self-reinforced composite material has excellent recyclability and is environmentally friendly compared to composite materials composed of other types of material, such as glass fiber reinforced composites (GFRP) and carbon fiber reinforced composites (CFRP). In this research, the manufactured self-reinforced composite material consists of an outer layer and an inner layer. To manufacture the outer layer, low density polyethylene (LDPE) films were laminated on high density polyethylene (HDPE) fabrics and knitted fabrics, and composite materials were prepared at various temperatures using hot stamping...
October 11, 2023: Polymers
https://read.qxmd.com/read/37857808/lighting-environment-adjustable-block-type-3d-indoor-pv-for-wireless-sensor-communication
#28
JOURNAL ARTICLE
Yeon Hyang Sim, Jung-Hyun Hwang, Min Ju Yun, Kyoungho Lee, Dong Yoon Lee, Seung I Cha
Demand is increasing for photovoltaics (PVs) as a result of the development of the Internet of Things and edge computing technologies. As the lighting environment is different for the applications, thus, PVs must be adjustable to various light environments in which systems are installed. PVs should therefore be capable of easily changing their morphology without damaging the cells. To address this problem, in this work, a three-dimensional (3D) structure that increases power output under omnidirectional light was applied to a crystalline silicon solar cell array using a block-type method...
October 19, 2023: Scientific Reports
https://read.qxmd.com/read/37830110/6impose-bridging-the-reality-gap-in-6d-pose-estimation-for-robotic-grasping
#29
JOURNAL ARTICLE
Hongpeng Cao, Lukas Dirnberger, Daniele Bernardini, Cristina Piazza, Marco Caccamo
6D pose recognition has been a crucial factor in the success of robotic grasping, and recent deep learning based approaches have achieved remarkable results on benchmarks. However, their generalization capabilities in real-world applications remain unclear. To overcome this gap, we introduce 6IMPOSE, a novel framework for sim-to-real data generation and 6D pose estimation. 6IMPOSE consists of four modules: First, a data generation pipeline that employs the 3D software suite Blender to create synthetic RGBD image datasets with 6D pose annotations...
2023: Frontiers in Robotics and AI
https://read.qxmd.com/read/37828050/maxsim-multi-angle-crossing-structured-illumination-microscopy-with-height-controlled-mirror-for-3d-topological-mapping-of-live-cells
#30
JOURNAL ARTICLE
Pedro Felipe Gardeazabal Rodriguez, Yigal Lilach, Abhijit Ambegaonkar, Teresa Vitali, Haani Jafri, Hae Won Sohn, Matthew Dalva, Susan Pierce, Inhee Chung
Mapping 3D plasma membrane topology in live cells can bring unprecedented insights into cell biology. Widefield-based super-resolution methods such as 3D-structured illumination microscopy (3D-SIM) can achieve twice the axial ( ~ 300 nm) and lateral ( ~ 100 nm) resolution of widefield microscopy in real time in live cells. However, twice-resolution enhancement cannot sufficiently visualize nanoscale fine structures of the plasma membrane. Axial interferometry methods including fluorescence light interference contrast microscopy and its derivatives (e...
October 12, 2023: Communications Biology
https://read.qxmd.com/read/37814782/mri-based-radiomics-approach-for-differentiating-juvenile-myoclonic-epilepsy-from-epilepsy-with-generalized-tonic-clonic-seizures-alone
#31
JOURNAL ARTICLE
Yongsik Sim, Seung-Koo Lee, Min Kyung Chu, Won-Joo Kim, Kyoung Heo, Kyung Min Kim, Beomseok Sohn
BACKGROUND: The clinical presentation of juvenile myoclonic epilepsy (JME) and epilepsy with generalized tonic-clonic seizures alone (GTCA) is similar, and MRI scans are often perceptually normal in both conditions making them challenging to differentiate. PURPOSE: To develop and validate an MRI-based radiomics model to accurately diagnose JME and GTCA, as well as to classify prognostic groups. STUDY TYPE: Retrospective. POPULATION: 164 patients (127 with JME and 37 with GTCA) patients (age 24...
October 10, 2023: Journal of Magnetic Resonance Imaging: JMRI
https://read.qxmd.com/read/37786707/augmented-super-resolution-radial-fluctuations-asrrf-pushing-the-limits-of-structured-illumination-microscopy
#32
Heng Zhang, Jianhang Wang, Luhong Jin, Yunqi Zhu, Yuting Guo, Meng Zhang, Yuhui Zhang, Zhixiong Wang, Yisun Su, Yicong Wu, Baohua Ji, Derek Toomre, Xu Liu, Yingke Xu
Structured illumination microscopy (SIM) is a versatile super-resolution technique known for its compatibility with a wide range of probes and fast implementation. While 3D SIM is capable of achieving a spatial resolution of ∼120 nm laterally and ∼300 nm axially, attempting to further enhance the resolution through methods such as nonlinear SIM or 4-beam SIM introduces complexities in optical configurations, increased phototoxicity, and reduced temporal resolution. Here, we have developed a novel method that combines SIM with augmented super-resolution radial fluctuations (aSRRF) utilizing a single image through image augmentation...
July 6, 2023: bioRxiv
https://read.qxmd.com/read/37785916/dosimetry-validation-of-mr-only-treatment-planning-based-upon-the-synthetic-mrcat-pelvis-with-continuous-hounsfield-units-in-prostate-cancer
#33
JOURNAL ARTICLE
M Benayun
PURPOSE/OBJECTIVE(S): MR-based radiotherapy delivery systems are increasingly encouraging treatment planning based upon an AI generated synthetic CT created from an MR image. Concerns remain concerning the dosimetric accuracy of this approach. AIM: to evaluate and compare the feasibilities and dosimetry of magnetic resonance (MR) image-based planning using pelvic synthetic computed tomography (sCT) versus conventional computed tomography (cCT) based planning. We used the new MRCAT pelvis MRI-SIM (1...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37785338/multidisciplinary-institutional-guidelines-for-workflow-efficiency-in-optimizing-patient-start-time
#34
JOURNAL ARTICLE
C R Kilar, D A Clump, R A C Siochi
PURPOSE/OBJECTIVE(S): Radiation Oncology is a field which is reliant on the intradisciplinary team and efficient completion of respected tasks. The purpose of this study was to analyze institutional workflow efficiency by comparing current practices to team-member expectations. MATERIALS/METHODS: To measure workflow efficiency, the Aria database was queried to find sessions for treatment plans with a CT Sim image and a first treatment date between 2/23/2021 and 12/15/2022...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37784356/rap80-phase-separation-at-dna-double-strand-break-promotes-brca1-recruitment-and-tumor-radio-resistance
#35
JOURNAL ARTICLE
C Qin, Y L Wang, J Y Zhou, X Wan, X Fan
PURPOSE/OBJECTIVE(S): RAP80 has been characterized as a component of the BRCA1-A complex and is responsible for the recruitment of BRCA1 to DNA double-strand breaks (DSBs). However, we and others found that the recruitment of RAP80 and BRCA1 are not absolutely temporally synchronized, indicating that other mechanisms, apart from physical interaction, may be implicated. Recently, we and other groups have reported that liquid-liquid phase separation (LLPS) is a pivotal mechanism underlying DNA repair factors condensation at DSBs and their function...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37769914/boosting-oxygen-evolution-reaction-activity-with-mo-incorporated-nife-ldh-electrocatalyst-for-efficient-water-electrolysis
#36
JOURNAL ARTICLE
Asiya M Tamboli, Younghan Jung, Junseok Sim, Bonghyun Kim, Wan Sik Kim, MinJoong Kim, Changsoo Lee, Kilwon Kim, ChangHyuck Lim, KyongHwan Kim, Hyun-Seok Cho, Chang-Hee Kim
This work demonstrates a simple and scalable methodology for the binder-free direct growth of Mo-doped NiFe-layered double hydroxides on a nickel substrate via an electrodeposition route at room temperature. A three-dimensional (3D) nanosheet array morphology of the electrocatalyst provides immense electrochemical surface area as well as abundant catalytically active sites. Mo incorporation in the NiFe-LDH plays a crucial role in regulating the catalytic activity of oxygen evolution reaction (OER). The prepared electrocatalyst exhibited low overpotential (i...
September 26, 2023: Chemosphere
https://read.qxmd.com/read/37760105/stress-effect-in-the-knee-joint-based-on-the-fibular-osteotomy-level-and-varus-deformity-a-finite-element-analysis-study
#37
JOURNAL ARTICLE
Yeokyung Kang, Jungsung Kim, Jae Ang Sim, Myeong Moon, Jong-Chul Park, Sung Ha Cho, Byung Hoon Lee
Proximal fibular osteotomy (PFO) was found to relieve pain and improve knee function in patients with medial compartment knee osteoarthritis (OA). Therapy redistributes the load applied from the inside to the outside and alleviates the load applied on the inside through fibula osteotomy. Therefore, the clinical effect of fibular osteotomy using the finite element (FE) method was evaluated to calculate the exact change in stress inside a knee joint with varus deformity. Using CT and MRI images of a patient's lower extremities, 3D models of the bone, cartilage, meniscus, and ligaments were constructed...
August 24, 2023: Bioengineering
https://read.qxmd.com/read/37712225/improvement-of-lipid-detection-in-mouse-brain-and-human-uterine-tissue-sections-using-in-situ-matrix-enhanced-secondary-ion-mass-spectrometry
#38
JOURNAL ARTICLE
Thomas Daphnis, Benjamin Tomasetti, Vincent Delmez, Kevin Vanvarenberg, Véronique Préat, Charlotte Thieffry, Patrick Henriet, Christine Dupont-Gillain, Arnaud Delcorte
The potential of mass spectrometry imaging, and especially ToF-SIMS 2D and 3D imaging, for submicrometer-scale, label-free molecular localization in biological tissues is undisputable. Nevertheless, sensitivity issues remain, especially when one wants to achieve the best lateral and vertical (nanometer-scale) resolution. In this study, the interest of in situ matrix transfer for tissue analysis with cluster ion beams (Bin + , Arn + ) is explored in detail, using a series of six low molecular weight acidic (MALDI) matrices...
September 15, 2023: Journal of the American Society for Mass Spectrometry
https://read.qxmd.com/read/37680243/exploring-the-effects-of-3d-360%C3%A2-vr-and-2d-viewing-modes-on-gaze-behavior-head-excursion-and-workload-during-a-boxing-specific-anticipation-task
#39
JOURNAL ARTICLE
Mildred Loiseau Taupin, Thomas Romeas, Lauryn Juste, David R Labbé
INTRODUCTION: Recent evidence has started to demonstrate that 360°VR, a type of VR that immerses a user within a 360° video, has advantages over two-dimensional (2D) video displays in the context of perceptual-cognitive evaluation and training. However, there is currently a lack of empirical evidence to explain how perceptual-cognitive strategies differ between these two paradigms when performing sports-related tasks. Thus, the objective of this study was to examine and compare the impact of different viewing conditions (e...
2023: Frontiers in Psychology
https://read.qxmd.com/read/37658339/structural-changes-in-perineuronal-nets-and-their-perforating-gabaergic-synapses-precede-motor-coordination-recovery-post-stroke
#40
JOURNAL ARTICLE
Egor Dzyubenko, Katrin I Willig, Dongpei Yin, Maryam Sardari, Erdin Tokmak, Patrick Labus, Ben Schmermund, Dirk M Hermann
BACKGROUND: Stroke remains one of the leading causes of long-term disability worldwide, and the development of effective restorative therapies is hindered by an incomplete understanding of intrinsic brain recovery mechanisms. Growing evidence indicates that the brain extracellular matrix (ECM) has major implications for neuroplasticity. Here we explored how perineuronal nets (PNNs), the facet-like ECM layers surrounding fast-spiking interneurons, contribute to neurological recovery after focal cerebral ischemia in mice with and without induced stroke tolerance...
September 1, 2023: Journal of Biomedical Science
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