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https://www.readbyqxmd.com/read/29161008/mapping-the-functional-tortuosity-and-spatio-temporal-heterogeneity-of-porous-polymer-membranes-with-super-resolution-nanoparticle-tracking
#1
Yu Cai, Daniel K Schwartz
As particles flow through porous media, they follow complex pathways and experience heterogeneous environments that are challenging to characterize. Tortuosity is often used as a parameter to characterize the complexity of pathways in porous materials and is useful in understanding hindered mass transport in industrial filtration and mass separation processes. However, conventional calculations of tortuosity provide only average values under static conditions; they are insensitive to the intrinsic heterogeneity of porous media and do not account for potential effects of operating conditions...
November 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29160552/cotton-rats-sigmodon-hispidus-possess-pharyngeal-pouch-remnants-originating-from-different-primordia
#2
Teppei Nakamura, Osamu Ichii, Takao Irie, Tatsuya Mizoguchi, Akio Shinohara, Hirokazu Kouguchi, Yuji Sunden, Saori Otsuka-Kanazawa, Yaser Hosny Ali Elewa, Chihiro Koshimoto, Ken-Ichi Nagasaki, Yasuhiro Kon
Pharyngeal pouches in mammals develop into specific derivatives. If the differentiation of the pharyngeal pouches is anomalous, their remnants can result in cysts, sinuses, and fistulae in the differentiated organs or around the neck. In the present study, we found several pharyngeal pouch remnants, such as cystic structures in thymus and parathyroid gland and fossulae extended from the piriform fossa, in the inbred cotton rats maintained at Hokkaido Institute of Public Health (HIS/Hiph) and University of Miyazaki (HIS/Mz)...
November 21, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/29160235/possibile-half-metallicity-and-variable-range-hopping-transport-in-sb-substituted-fe-sub-2-sub-tisn-heusler-alloys
#3
Sayan Chaudhuri, P A Bhobe, Arun Kumar Nigam
Investigation of magnetotransport properties on Fe<sub>2</sub>TiSn<sub>1-x</sub>Sb<sub>x</sub> with 0 ≤ x ≤ 0.6 are presented in this paper. The substitution of Sb in place of Sn decreases the antisite disorder as evident from X ray diffraction patterns as well as from transport properties measurement. The much-disputed upturn in low temperature electrical resistivity of Fe<sub>2</sub>TiSn has been demonstrated to be a result of weak localization induced by antisite disorder...
November 21, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29159145/ph-responsive-cross-linked-polymeric-matrices-based-on-natural-polymers-effect-of-process-variables-on-swelling-characterization-and-drug-delivery-properties
#4
Fahad Naeem, Samiullah Khan, Aamir Jalil, Nazar Muhammad Ranjha, Amina Riaz, Malik Salman Haider, Shoaib Sarwar, Fareha Saher, Samrin Afzal
Introduction: The current work was aimed to design and synthesize novel crosslinked pH-sensitive gelatin/pectin (Ge/Pec) hydrogels using different polymeric ratios and to explore the effect of polymers and degree of crosslinking on dynamic, equilibrium swelling and in vitro release behavior of the model drug (Mannitol). Methods: The Ge/Pec based hydrogels were prepared using glutaraldehyde as the crosslinker. Various structural parameters that affect their release behavior were determined, including swelling study, porosity, sol-gel analysis, average molecular weight between crosslinks (Mc), volume fraction of polymer (V2,s), solvent interaction parameter (χ) and diffusion coefficient...
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/29159036/eeg-oscillations-during-word-processing-predict-mci-conversion-to-alzheimer-s-disease
#5
Ali Mazaheri, Katrien Segaert, John Olichney, Jin-Chen Yang, Yu-Qiong Niu, Kim Shapiro, Howard Bowman
Only a subset of mild cognitive impairment (MCI) patients progress to develop a form of dementia. A prominent feature of Alzheimer's disease (AD) is a progressive decline in language. We investigated if subtle anomalies in EEG activity of MCI patients during a word comprehension task could provide insight into the likelihood of conversion to AD. We studied 25 amnestic MCI patients, a subset of whom developed AD within 3-years, and 11 elderly controls. In the task, auditory category descriptions (e.g., 'a type of wood') were followed by a single visual target word either semantically congruent (i...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29159013/computational-and-theoretical-approaches-for-studies-of-a-lipid-recognition-protein-on-biological-membranes
#6
REVIEW
Eiji Yamamoto
Many cellular functions, including cell signaling and related events, are regulated by the association of peripheral membrane proteins (PMPs) with biological membranes containing anionic lipids, e.g., phosphatidylinositol phosphate (PIP). This association is often mediated by lipid recognition modules present in many PMPs. Here, I summarize computational and theoretical approaches to investigate the molecular details of the interactions and dynamics of a lipid recognition module, the pleckstrin homology (PH) domain, on biological membranes...
2017: Biophysics and Physicobiology
https://www.readbyqxmd.com/read/29158534/changes-to-yucat%C3%A3-n-peninsula-precipitation-associated-with-salinity-and-temperature-extremes-of-the-caribbean-sea-during-the-maya-civilization-collapse
#7
Henry C Wu, Thomas Felis, Denis Scholz, Cyril Giry, Martin Kölling, Klaus P Jochum, Sander R Scheffers
Explanations of the Classic Maya civilization demise on the Yucatán Peninsula during the Terminal Classic Period (TCP; ~CE 750-1050) are controversial. Multiyear droughts are one likely cause, but the role of the Caribbean Sea, the dominant moisture source for Mesoamerica, remains largely unknown. Here we present bimonthly-resolved snapshots of reconstructed sea surface temperature (SST) and salinity (SSS) variability in the southern Caribbean from precisely dated fossil corals. The results indicate pronounced interannual to decadal SST and SSS variability during the TCP, which may be temporally coherent to precipitation anomalies on the Yucatán...
November 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29153973/airborn-gamma-ray-spectrometric-data-as-guide-for-probable-hydrocarbon-accumulations-at-al-laqitah-area-central-eastern-desert-of-egypt
#8
Ahmed A Nigm, Mohamed A S Youssef, Fatema M Abdelwahab
An exploration method has been developed to understand the relation between the radiometric measurements and the subsurface petroleum accumulations, where subtle anomalous patterns of radiation flux are detected over subsurface hydrocarbon basins. This technique is mainly based on utilizing the aerial gamma-ray spectral data in the prospecting for petroleum in stratigraphic and structural traps. Al-Laqitah area, Central Eastern Desert, Egypt, was selected to apply this method on its recorded aerial gamma-ray spectrometric survey data...
November 1, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29153581/novel-application-of-micro-computerized-tomography-for-morphologic-characterization-of-the-murine-penis
#9
Marisol O'Neill, Gene O Huang, Dolores J Lamb
BACKGROUND: The murine penis model has enriched our understanding of anomalous penile development. The morphologic characterization of the murine penis using conventional serial sectioning methods is labor intensive and prone to errors. AIM: To develop a novel application of micro-computerized tomography (micro-CT) with iodine staining for rapid, non-destructive morphologic study of murine penis structure. METHODS: Penises were dissected from 10 adult wild-type mice and imaged using micro-CT with iodine staining...
November 16, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29152525/do-you-what-i-say-people-reconstruct-the-syntax-of-anomalous-utterances
#10
Iva Ivanova, Holly P Branigan, Janet F McLean, Albert Costa, Martin J Pickering
We frequently experience and successfully process anomalous utterances. Here we examine whether people do this by 'correcting' syntactic anomalies to yield well-formed representations. In two structural priming experiments, participants' syntactic choices in picture description were influenced as strongly by previously comprehended anomalous (missing-verb) prime sentences as by well-formed prime sentences. Our results suggest that comprehenders can reconstruct the constituent structure of anomalous utterances - even when such utterances lack a major structural component such as the verb...
2017: Language, Cognition and Neuroscience
https://www.readbyqxmd.com/read/29152344/crystal-structure-of-akuammicine-an-indole-alkaloid-from-catharanthus-roseus
#11
Mahdi Yahyazadeh, Gerold Jerz, Dirk Selmar, Peter Winterhalter, Peter G Jones
The title compound, C20H22N2O2, an alkaloid isolated from the Madagascar periwinkle, crystallizes in P1 with two independent but closely similar mol-ecules in the unit cell. The mol-ecules are linked into pairs by two N-H⋯O=C hydrogen bonds. The absolute configuration was confirmed by anomalous dispersion effects as S at the 3 and 15 positions, and R at the 7 position.
November 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29152268/dextrocardia-with-asymptomatic-right-atrial-appendage-aneurysm-a-case-report
#12
Hossein Sate, Najmeh Reshadati, Parvaneh Aliakbarzadeh, Negin Molazadeh
Right atrial appendage aneurysm (RAAA) is rarely encountered with variable intracardiac anatomy. We report a case of asymptomatic RAAA in a patient with dextrocardia and anomalous origin of RCA from left coronary sinus which was treated successfully by CABG and the aneurysm was completely excised.
November 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29151094/glossolalia-and-aphasia-related-but-different-worlds
#13
Leila Chouiter, Jean-Marie Annoni
The word glossolalia, also referred to as "speaking in tongues," originates from the Greek "glossa" which means "language" and "Lalia" which means "speak." It simply means to talk language. On a linguistic perspective, glossolalia is characterized by almost no recognizable words or semantic content, apart from biblical words and phrases, with an overrepresentation of a small phonemes number, accelerated speech output, and modification of accents and melody. Its phonemic properties have been said to resemble those of the language(s) of the speaker...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29150435/biochemical-characterization-of-ints3-and-c9orf80-two-subunits-of-hnabp1-2-heterotrimeric-complex-in-nucleic-acid-binding
#14
Venkatasubramanian Vidhyasagar, Yujiong He, Manhong Guo, Tanu Talwar, Ravi Shankar Singh, Manisha Yadav, George Katselis, Franco J Vizeacoumar, Erique Lukong, Yuliang Wu
Human Nucleic Acid Binding Protein 1 and 2 (hNABP1 and hNABP2, also known as hSSB2 and hSSB1) form two separate and independent complexes with two identical proteins, integrator complex subunit 3 (INTS3) and C9ORF80. We and other groups have demonstrated that hNABP1 and 2 are single stranded (ss) DNA and RNA binding proteins, and function in DNA repair; however, the function of INTS3 and C9OFR80 remains elusive. In this study, we purified recombinant proteins INTS3 and C9ORF80 to near homogeneity. Both proteins exist as a monomer in solution, however C9ORF80 exhibits anomalous behavior on SDS-PAGE and gel filtration because of 48% random coil present in the protein...
November 17, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/29149556/evaluating-force-field-london-dispersion-coefficients-using-the-exchange-hole-dipole-moment-model
#15
Mohamad Mohebifar, Erin R Johnson, Christopher N Rowley
London dispersion interactions play an integral role in materials science and biophysics. Force fields for atomistic molecular simulations typically represent dispersion interactions by the 12-6 Lennard-Jones potential, using empirically-determined parameters. These parameters are generally underdetermined and there is no straightforward way to test if they are physically realistic. Alternatively, the exchange-hole dipole moment (XDM) model from density-functional theory predicts atomic and molecular London dispersion coefficients from first principles, providing an innovative strategy to validate the dispersion terms of molecular-mechanical force fields...
November 17, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29149232/stabilized-electrically-induced-helfrich-deformation-and-enhanced-color-tuning-in-cholesteric-liquid-crystals
#16
Meina Yu, Huai Yang, Deng-Ke Yang
When subjected to an AC electric field perpendicular to its layers, the cholesteric planar state may undergo a periodic layer undulation, known as the Helfrich deformation, which generates a color change of the reflected light. The Helfrich deformation of regular cholesteric liquid crystals is, however, unstable and easily taken over by the focal conic state, and thus the color tuning range is narrow. We demonstrated that the Helfrich deformation can be stabilized in a large electric field region by doping a bent dimer with an anomalously small bend elastic constant and dispersing a small amount of polymer network...
November 17, 2017: Soft Matter
https://www.readbyqxmd.com/read/29148642/rare-co-existence-of-coronary-anomalies-anomaly-of-origin-and-distribution-together-with-anomaly-of-intrinsic-coronary-artery-anomaly
#17
Abraha Hailu, Diana Chin, Carmine Musto, Rosario Fiorilli, Roberto Violini
We describe a 63 year old Romanian female patient admitted to our institution with complaints of typical angina and a diagnosis of non ST-elevation myocardial infarction. Coronary arteriography unveiled anomalous origin of a left circumflex coronary artery from the right coronary sinus of Valsalva near the right coronary ostium and a hyperdominant left anterior descending coronary artery giving off a posterior descending coronary artery with small distal-posterolateral left ventricular branch. The co-existence of a left circumflex coronary artery originating ectopically from the right sinus of Valsalva together with a posterior descending coronary artery originating from the distal end of the anterior descending artery is important to keep in mind especially by those doing coronary angiography in the cardiac catheterization laboratory...
January 2017: Ethiopian Medical Journal
https://www.readbyqxmd.com/read/29148628/clinical-significance-of-st-depression-at-exercise-stress-testing-in-competitive-athletes-usefulness-of-coronary-ct-during-screening
#18
Fabio Sperandii, Emanuele Guerra, Eliana Tranchita, Carlo Minganti, Chiara Lanzillo, Antonia Nigro, Federico Quaranta, Attilio Parisi, Mauro DI Roma, Luciano Maresca, Federica Fagnani, Leonardo Calò
BACKGROUND: Congenital coronary anomalies (CCAs) and coronary artery disease (CAD) arouse intense scientific and clinical interest in sports medicine and sports cardiology medical communities because of their potential to trigger sudden cardiac death (SCD) in athletes. Exercise stress testing represent the first instrumental assessment to evaluate electrocardiographic changes during effort. Coronary computed tomography angiography (CCTA) is an advanced accurate noninvasive imaging modality for excluding CAD and abnormalities of origin and course of coronary vessels...
November 17, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29147912/tracheal-agenesis-optimization-of-computed-tomography-diagnosis-by-airway-ventilation
#19
REVIEW
Marirosa Cristallo Lacalamita, Sebastien Fau, Aurelie Bornand, Isabelle Vidal, Antonella Martino, Isabelle Eperon, Seema Toso, Anne-Laure Rougemont, Sylviane Hanquinet
Tracheal agenesis is a rare and often lethal congenital defect that leads to airway emergency at birth. Computed tomography (CT) is the modality of choice to evaluate anomalous tracheal anatomy. The absence of spontaneous aeration of the tracheobronchial tree in children with tracheal agenesis makes CT interpretation difficult. We describe a procedure of airway management applied in two newborns with suspected tracheal agenesis. Correct airway management was performed immediately prior to CT examination by airway ventilation, with bag-valve mask alone in one case, and attached to an endotracheal tube placed into the esophagus in the other case...
November 17, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29146919/nucleosome-acidic-patch-targeting-binuclear-ruthenium-compounds-induce-aberrant-chromatin-condensation
#20
Gabriela E Davey, Zenita Adhireksan, Zhujun Ma, Tina Riedel, Deepti Sharma, Sivaraman Padavattan, Daniela Rhodes, Alexander Ludwig, Sara Sandin, Benjamin S Murray, Paul J Dyson, Curt A Davey
The 'acidic patch' is a highly electronegative cleft on the histone H2A-H2B dimer in the nucleosome. It is a fundamental motif for protein binding and chromatin dynamics, but the cellular impact of targeting this potentially therapeutic site with exogenous molecules remains unclear. Here, we characterize a family of binuclear ruthenium compounds that selectively target the nucleosome acidic patch, generating intra-nucleosomal H2A-H2B cross-links as well as inter-nucleosomal cross-links. In contrast to cisplatin or the progenitor RAPTA-C anticancer drugs, the binuclear agents neither arrest specific cell cycle phases nor elicit DNA damage response, but rather induce an irreversible, anomalous state of condensed chromatin that ultimately results in apoptosis...
November 17, 2017: Nature Communications
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