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https://www.readbyqxmd.com/read/28095113/quantitative-analysis-of-cell-surface-antigen-antibody-interaction-using-gaussia-princeps-luciferase-antibody-fusion-proteins
#1
Juliane Kums, Johannes Nelke, Benedikt Rüth, Viktoria Schäfer, Daniela Siegmund, Harald Wajant
Cell surface antigen-specific antibodies are of substantial diagnostic and therapeutic importance. The binding properties of such antibodies are usually evaluated by cell-free assays, in particular surface plasmon resonance (SPR) analysis, or flow cytometry. SPR analyses allow the detailed quantitative and dynamic evaluation of the binding properties of antibodies, but need purified, typically recombinantly produced antigens. It can, however, be difficult to produce the required antigen. Furthermore, cellular factors influencing the antigen-antibody interaction are not considered by this method...
January 17, 2017: MAbs
https://www.readbyqxmd.com/read/28076289/from-bacteria-to-chloroplasts-evolution-of-the-chloroplast-srp-system
#2
Dominik Ziehe, Beatrix Dünschede, Danja Schünemann
Chloroplasts derive from a prokaryotic symbiont that lost most of its genes during evolution. As a result, the great majority of chloroplast proteins are encoded in the nucleus and are posttranslationally imported into the organelle. The chloroplast genome encodes only a few proteins. These include several multispan thylakoid membrane proteins which are synthesized on thylakoid-bound ribosomes and cotranslationally inserted into the membrane. During evolution, ancient prokaryotic targeting machineries were adapted and combined with novel targeting mechanisms to facilitate post- and cotranslational protein transport in chloroplasts...
January 10, 2017: Biological Chemistry
https://www.readbyqxmd.com/read/28075607/efficacy-of-an-escherichia-coli-o157-h7-srp-vaccine-in-orally-challenged-goats-and-strain-persistence-over-time
#3
Jacob M Swift, Derek M Foster, Anna T Rogers, Hannah J Sylvester, Emily H Griffith, Megan E Jacob
Small ruminants have been implicated in outbreaks of Escherichia coli O157:H7 at livestock exhibitions throughout the United States. Additionally, goat meat or milk may serve as a reservoir for foodborne transmission of the organism. These associations highlight the public health importance of an effective strategy to reduce E. coli O157:H7 shedding in goats. We examined the efficacy of the SRP(®) vaccine in goats orally challenged with E. coli O157:H7. Mixed-breed goats (n = 14) were randomly allocated into vaccinated and unvaccinated treatments (n = 7 per treatment)...
January 11, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28071586/milestones-in-crh-research
#4
George P Chrousos, Emmanouil Zoumakis
The Corticotropin-releasing Hormone (CRH) mammalian family members include CRH, urocortin I, Stresscopin (SCP) and Stresscopin-related peptide (SRP), along with the CRH receptors type 1 (CRHR1) and type 2 (CRHR2), and CRH-binding protein (CRH-BP). These family members differ in their tissue distribution and pharmacology. Several studies have provided evidence supporting an important role of this family in the regulation of the neuroendocrine and behavioral responses to stress. Regulation of the relative contribution of CRH and its homologs and the two CRH receptors in brain CRH pathways may be essential in coordinating physiologic responses to stress...
January 9, 2017: Current Molecular Pharmacology
https://www.readbyqxmd.com/read/28070922/an-open-label-randomized-control-trial-of-hopping-and-jumping-training-versus-sensorimotor-rehabilitation-programme-on-postural-capacities-in-individuals-with-intellectual-disabilities
#5
Rihab Borji, Sonia Sahli, Rym Baccouch, Rabeb Laatar, Hiba Kachouri, Haithem Rebai
BACKGROUND: This study aimed to compare the effectiveness of a hopping and jumping training programme (HJP) versus a sensorimotor rehabilitation programme (SRP) on postural performances in children with intellectual disability. METHODS: Three groups of children with intellectual disability participated in the study: the HJP group, the SRP group and a control group. Postural capacities were tested with the Berg Balance Scale (BBS) and the Tinetti tests. The HJP and the SRP groups participated in the training programmes for eight weeks...
January 10, 2017: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/28069309/characterizing-nutrient-distributions-and-fluxes-in-a-eutrophic-reservoir-midwestern-united-states
#6
Alexandra R Pearce, Lisa G Chambers, Elizabeth A Hasenmueller
Harmful algal blooms are increasingly common in aquatic ecosystems and have been linked to runoff from agricultural land. This study investigated the internal nutrient (i.e., phosphorus (P) and nitrogen (N)) dynamics of a eutrophic reservoir in the Midwestern United States to constrain the potential for sedimentary nutrients to stimulate harmful algal blooms. The spatial distribution of nutrients in the water column (soluble reactive P (SRP), nitrate/nitrite-N (NOx-N), and ammonium-N (NH4(+)-N)) and sediments (total P, total carbon (C), total N, and organic matter (OM)) were quantified and mapped...
January 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28066895/anti-hmgcr-necrotizing-myopathy-masquerading-as-a-muscular-dystrophy-in-a-child
#7
Payam Mohassel, A Reghan Foley, Sandra Donkervoort, Pierre R Fequiere, Katherine Pak, Carsten G Bönnemann, Andrew L Mammen
INTRODUCTION: Immune-mediated necrotizing myopathies (IMNM) are characterized by progressive weakness, elevated serum creatine kinase levels, and necrotizing myopathic features on muscle biopsy. Presence of highly specific autoantibodies against signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl- coenzyme A reductase (HMGCR) can aid in recognition and confirmation of IMNMs. METHODS: We describe a boy with HMGCR-positive necrotizing myopathy and highlight the clinical features in this patient...
January 9, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28054408/non-native-fish-stocking-alters-stream-ecosystem-nutrient-dynamics
#8
Alexander V Alexiades, Alexander S Flecker, Clifford E Kraft
Each year, millions of hatchery raised fish are stocked annually into streams and rivers worldwide, yet the effects of hatchery raised fish on stream nutrient cycles has seldom been examined. We quantified the influence of supplemental non-native fish stocking, a widespread recreational fishery management practice, on in-stream nutrient storage and cycling. We predicted that supplemental, hatchery-raised brown trout (Salmo trutta) stocking would result in increased N and P supply relative to in-stream biotic demand for those nutrients and that stocked fishes would remineralize and store a significantly greater amount of N and P than the native fish community, due to higher areal biomass...
January 5, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28050316/effectiveness-of-alendronate-as-an-adjunct-to-scaling-and-root-planing-in-the-treatment-of-periodontitis-a-meta-analysis-of-randomized-controlled-clinical-trials
#9
Jin Chen, Qian Chen, Bo Hu, Yunji Wang, Jinlin Song
PURPOSE: Alendronate has been proposed as a local and systemic drug treatment used as an adjunct to scaling and root planing (SRP) for the treatment of periodontitis. However, its effectiveness has yet to be conclusively established. The purpose of the present meta-analysis was to assess the effectiveness of SRP with alendronate on periodontitis compared to SRP alone. METHODS: Five electronic databases were used by 2 independent reviewers to identify relevant articles from the earliest records up to September 2016...
December 2016: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/28035923/neural-correlates-of-self-reference-effect-in-early-alzheimer-s-disease
#10
Malo Gaubert, Nicolas Villain, Brigitte Landeau, Florence Mézenge, Stéphanie Egret, Audrey Perrotin, Serge Belliard, Vincent de La Sayette, Francis Eustache, Béatrice Desgranges, Gaël Chételat, Géraldine Rauchs
Information that is processed with reference to the self (i.e., self-referential processing, SRP) is generally associated with better remembering than information processed in a semantic condition. This benefit of self on memory performance is called self-reference effect (SRE). In the present study, we assessed changes in the SRE and SRP-related brain activity in patients diagnosed with mild cognitive impairment or early Alzheimer's disease (MCI/AD). Fifteen patients with confirmed amyloid-β deposits (positive florbetapir-PET scan) and 28 healthy controls (negative florbetapir-PET scan) were included...
December 30, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28031281/pnpase-rnase-e-g-and-ybey-are-involved-in-the-maturation-of-4-5s-rna-in-corynebacterium-glutamicum
#11
Tomoya Maeda, Yuya Tanaka, Masaaki Wachi, Masayuki Inui
: Corynebacterium glutamicum has been applied for industrial production of various metabolites such as amino acids. To understand the biosynthesis of membrane protein in this bacterium, we investigated the process of signal recognition particle (SRP) assembly. SRP is found in all three domains of life and plays an important role in the membrane insertion of proteins. SRP RNA is initially transcribed as precursor molecules; however, relatively little is known about its maturation. In C...
December 28, 2016: Journal of Bacteriology
https://www.readbyqxmd.com/read/28027546/experimental-reconstruction-of-historical-wbc-measuring-procedure-in-1986
#12
V V Vasynenko, O M Ivanova, L O Lytvynets, V O Pikta, G M Zadorozhna, M I Chepurnyi, I A Likhtariov
OBJECTIVE: Examination and experimental reconstruction of the historical WBC measuring procedure in 1986 and estimation of the minimum detectable activity (MDA) of those measurements. MATERIALS AND METHODS: The SRP 68 01 gamma spectrometer with attached scintillation detector based on a NaI(Tl) O 30 x 25 mm2 crystal and NC 482 ВМ one channel spectrometer (Bicron Co.) with attached scintillation detector based on a NaI(Tl) O 52 x 52 mm2 crystal were used for the study...
December 2016: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/28025436/the-clinical-and-systemic-effects-of-periodontal-treatment-in-diabetic-and-non-diabetic-obese-patients
#13
Zekeriya Taşdemir, Funda Özsarı Taşdemir, İsmail Koçyiğit, Cevat Yazıcı, Cem A Gürgan
The purpose of the present study was to evaluate the response to periodontal management in obese individuals with poorly controlled diabetes mellitus (DM) and obese individuals without DM. Changes in clinical and biochemical parameters were also investigated. Seventeen obese patients with poorly controlled DM and 14 obese non-DM patients with generalized chronic periodontitis were enrolled. The anthropometric measurements, periodontal parameters, and serum levels of lipid (triglyceride, high-density lipoprotein cholesterol, total cholesterol, low-density lipoprotein cholesterol) and glucose (fasting plasma glucose [FPG], insulin, insulin resistance [IR], hemoglobin [Hb]A1c) metabolism, pro-inflammatory mediators (high-sensitivity C-reactive protein, tumor necrosis factor-α [TNF-α] and Pentraxim-3), and interleukin-6 were measured before and at 3 months, and 6 months after full-mouth scaling and root planing (FM-SRP) together with full-mouth disinfection (FMD)...
2016: Journal of Oral Science
https://www.readbyqxmd.com/read/27980332/antibiotics-in-aggressive-periodontitis-is-there-a-clinical-benefit
#14
Anjana Rajendra, Silvia Spivakovsky
Data sourcesMedline, Embase and CENTRAL databases were searched up to December 2014. Unpublished data were sought by searching a database listing unpublished studies OpenGray [http://www.opengrey.eu/], formerly OpenSIGLE.Study selectionRandomised clinical trials assessing treatment of patients with AgP comparing scaling and root planing (SRP) alone with SRP plus a single antibiotic or a combination of drugs with a minimum of three months follow-up were considered. Studies specifically designed to evaluate smokers or subjects with diabetes mellitus and HIV/AIDS were not included...
December 2016: Evidence-based Dentistry
https://www.readbyqxmd.com/read/27977669/on-the-spatial-organization-of-mrna-plasmids-and-ribosomes-in-a-bacterial-host-overexpressing-membrane-proteins
#15
Lieke A van Gijtenbeek, Andrew Robinson, Antoine M van Oijen, Bert Poolman, Jan Kok
By using fluorescence imaging, we provide a time-resolved single-cell view on coupled defects in transcription, translation, and growth during expression of heterologous membrane proteins in Lactococcus lactis. Transcripts encoding poorly produced membrane proteins accumulate in mRNA-dense bodies at the cell poles, whereas transcripts of a well-expressed homologous membrane protein show membrane-proximal localization in a translation-dependent fashion. The presence of the aberrant polar mRNA foci correlates with cessation of cell division, which is restored once these bodies are cleared...
December 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27966504/evaluation-of-efficacy-of-photodynamic-therapy-as-an-adjunct-to-nonsurgical-periodontal-therapy-in-treatment-of-chronic-periodontitis-patients-a-clinico-microbiological-study
#16
K Ravi Raj, Svvs Musalaiah, M Nagasri, P Aravind Kumar, P Indeevar Reddy, M Greeshma
BACKGROUND AND OBJECTIVES: Photodynamic therapy (PDT) is a local noninvasive treatment modality without side effects caused by antibiotics. The aim of this study was to evaluate the efficacy of adjunctive use of PDT with scaling and root planing as compared with SRP alone in the treatment of chronic periodontitis. SUBJECTS AND METHODS: Twenty participants with chronic periodontitis having probing pocket depths (PDs) of ≥5 mm were selected for the study. Patients were randomly divided into control group and test group with ten patients in each group...
September 2016: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/27932215/the-land-use-legacy-effect-towards-a-mechanistic-understanding-of-time-lagged-water-quality-responses-to-land-use-cover
#17
Sherry L Martin, Daniel B Hayes, Anthony D Kendall, David W Hyndman
Numerous studies have linked land use/land cover (LULC) to aquatic ecosystem responses, however only a few have included the dynamics of changing LULC in their analysis. In this study, we explicitly recognize changing LULC by linking mechanistic groundwater flow and travel time models to a historical time series of LULC, creating a land-use legacy map. We then illustrate the utility of legacy maps to explore relationships between dynamic LULC and lake water chemistry. We tested two main concepts about mechanisms linking LULC and lake water chemistry: groundwater pathways are an important mechanism driving legacy effects; and, LULC over multiple spatial scales is more closely related to lake chemistry than LULC over a single spatial scale...
February 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27928683/specific-autoantibodies-in-dermatomyositis-a-helpful-tool-to-classify-different-clinical-subsets
#18
Giulia Merlo, Andrea Clapasson, Emanuele Cozzani, Luigi Sanna, Giampaola Pesce, Marcello Bagnasco, Martina Burlando, Aurora Parodi
Autoantibodies are important in the diagnosis of dermatomyositis. They can be divided in two different groups: myositis-associated autoantibodies (MAA) prevailing in overlap syndromes, and myositis-specific autoantibodies (MSA), with diagnostic specificity exceeding 90%. Our purpose was to detect retrospectively the prevalence of the most common MSAs in a group of 19 adult DM patients (13 women, 6 men). A severe DM (SDM), with extensive cutaneous and muscular manifestations, dysphagia, and sometimes pneumopathy, was detected in ten cases...
December 7, 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27925158/mutations-in-dync2h1-the-cytoplasmic-dynein-2-heavy-chain-1-motor-protein-gene-cause-short-rib-polydactyly-type-i-saldino-noonan-type
#19
Nora Badiner, Stephanie Paige Taylor, Kimberly Forlenza, Ralph S Lachman, Michael Bamshad, Deborah Nickerson, Daniel H Cohn, Deborah Krakow
The short-rib polydactyly syndromes (SRPS) are autosomal recessively inherited, genetically heterogeneous skeletal ciliopathies. SRPS phenotypes were historically categorized as types I-IV, with type I first delineated by Saldino and Noonan in 1972. Characteristic findings among all forms of SRP include short horizontal ribs, short limbs and polydactyly. The SRP type I phenotype is characterized by a very small thorax, extreme micromelia, very short, poorly mineralized long bones, and multiple organ system anomalies...
December 7, 2016: Clinical Genetics
https://www.readbyqxmd.com/read/27922841/stress-resiliency-practices-in-neonatal-nurses
#20
Lisa M Pannell, Lynn Rowe, Salena Tully
BACKGROUND: Multiple environmental changes were experienced in a large level III neonatal intensive care unit (NICU) causing a perception of work-related stress leading to high nurse turnover, decreased engagement, and decreased satisfaction. PURPOSE: To identify a preintervention measure of perceived stress resiliency and ranking of interpretive styles in a population of neonatal, bedside registered nurses faced with a change in the physical practice environment...
December 5, 2016: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
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