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https://www.readbyqxmd.com/read/28213560/identification-of-putative-substrates-of-sec2-a-chloroplast-inner-envelope-translocase
#1
Yubing Li, Jonathan R Martin, Giovanni A Aldama, Donna E Fernandez, Kenneth Cline
Most chloroplast proteins are synthesized in the cytosol and imported into chloroplasts. Many imported proteins are further targeted to the thylakoid membrane and lumen by the SEC1, TAT or SRP/ALB3 translocases. Others are targeted to the inner chloroplast envelope membrane by un-described translocase(s). Recently, a second SEC system (SEC2) consisting of SCY2, SECE2, and SECA2 was found in the chloroplast envelope. Null mutants of SCY2 in Arabidopsis exhibit a severe embryo lethal phenotype. To investigate the function of SEC2 system in plants, we used inducible RNAi to knockdown SCY2 in Arabidopsis...
February 17, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28212109/sustainable-exposure-prevention-through-innovative-detection-and-remediation-technologies-from-the-niehs-superfund-research-program
#2
Heather F Henry, William A Suk
Innovative devices and tools for exposure assessment and remediation play an integral role in preventing exposure to hazardous substances. New solutions for detecting and remediating organic, inorganic, and mixtures of contaminants can improve public health as a means of primary prevention. Using a public health prevention model, detection and remediation technologies contribute to primary prevention as tools to identify areas of high risk (e.g. contamination hotspots), to recognize hazards (bioassay tests), and to prevent exposure through contaminant cleanups...
February 17, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/28207941/mfg-e8-inhibits-periodontitis-in-non-human-primates-and-its-gingival-crevicular-fluid-levels-can-differentiate-periodontal-health-from-disease-in-humans
#3
Tetsuhiro Kajikawa, Fatimah Meshikhes, Tomoki Maekawa, Evlambia Hajishengallis, Kavita B Hosur, Toshiharu Abe, Kevin Moss, Triantafyllos Chavakis, George Hajishengallis
AIM: We have previously shown that the secreted glycoprotein MFG-E8 has anti-inflammatory and anti-osteoclastogenic properties. Our objective was to investigate the potential of MFG-E8 as a diagnostic or therapeutic agent in periodontitis. MATERIALS AND METHODS: Periodontitis was induced in non-human primates (NHPs) by placing ligatures around posterior teeth on both halves of the mandible for a split-mouth design: one side was treated with MFG-E8-Fc and the other with Fc control...
February 16, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28196160/clinical-efficacy-of-subgingivally-delivered-1-2-mg-simvastatin-in-the-treatment-of-patients-with-aggressive-periodontitis-a-randomized-controlled-clinical-trial
#4
Priyanka N, A Abhilash, Shahab Saquib, Nikhil Malgaonkar, Nitin Kudyar, Aashima Gupta, Nitish Kalra, A R Pradeep
Simvastatin (SMV) is a specific competitive inhibitor of 3-hydroxy-2-methylglutaryl coenzyme A reductase that promotes bone formation. The present clinical trial was designed to investigate the effectiveness of 1.2 mg SMV as a local drug delivery system and as an adjunct to scaling and root planing (SRP) in the treatment of aggressive periodontitis (AgP). A total of 68 intrabony defects from 24 patients with AgP were treated either with 1.2 mg SMV gel or placebo gel. The subjects were randomly assigned to SRP + placebo (group 1; n = 12) or SRP + SMV (group 2; n = 12)...
March 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28193694/different-cav1-3-channel-isoforms-control-distinct-components-of-the-synaptic-vesicle-cycle-in-auditory-inner-hair-cells
#5
Philippe Fy Vincent, Yohan Bouleau, Gilles Charpentier, Alice Emptoz, Saaid Safieddine, Christine Petit, Didier Dulon
The mechanisms orchestrating transient and sustained exocytosis in auditory inner hair cells (IHCs) remain largely unknown. These exocytotic responses are believed to mobilize sequentially a readily releasable pool of vesicles (RRP) underneath the synaptic ribbons and a slowly releasable pool of vesicles (SRP) at farther distance from them. They are both governed by Cav1.3 channels and require otoferlin as Ca(2+) sensor but whether they use the same Cav1.3 isoforms is still unknown. Using whole cell patch clamp recordings in post-hearing mice, we show that only a proportion (∼25 %) of the total Ca(2+) current in IHCs, displaying fast inactivation and resistance to 20 μM nifedipine, a L-type Ca(2+) channel blocker, is sufficient to trigger RRP but not SRP exocytosis...
February 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28188919/clinical-efficacy-of-photodynamic-therapy-adjunctive-to-scaling-and-root-planing-in-the-treatment-of-chronic-periodontitis-a-systematic-review-and-meta-analysis
#6
Dong Xue, Lu Tang, Yuhao Bai, Qian Ding, Pengcheng Wang, Ying Zhao
PURPOSE: To evaluate the clinical efficacy of photodynamic therapy (PDT) adjunctive to scaling and root planing (SRP) in patients with untreated chronic periodontitis based on the up-to-date evidence. METHODS: MEDLINE and the Cochrane Library were systematically searched to identify eligible random controlled trials (RCTs), supplemented by a manual literature search. Mean differences (MD) and the corresponding 95% confidence intervals (CI) of probing depth (PD) reduction and clinical attachment level (CAL) gain were synthesized...
February 7, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28185653/long-term-changes-in-nutrients-chlorophyll-a-and-their-relationships-in-a-semi-enclosed-eutrophic-ecosystem-bohai-bay-china
#7
Yinhuan Qiao, Jianfeng Feng, Shangfa Cui, Lin Zhu
As the representative semi-enclosed bay of China, Bohai Bay has experienced severe eutrophication in recent decades. Monitoring data from 1995 to 2013 were analysed by generalized additive models (GAMs) to explore the temporal variations in nutrients concentrations, nutrient ratios, chlorophyll a (Chl a) concentrations and the responses of Chl a to the changes in nutrients in the spring and summer. The results showed that dissolved inorganic nitrogen (DIN) decreased from 1995 to 2000 but increased after 2000 in both the spring and summer, and soluble reactive phosphorus (SRP) decreased while the molar nitrogen/phosphorus (N/P) ratios (DIN to SRP) increased over the last two decades...
February 6, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28177411/influence-of-controlled-drainage-and-liquid-dairy-manure-application-on-phosphorus-leaching-from-intact-soil-cores
#8
Eric O Young, Justin R Geibel, Donald S Ross
Controlled drainage can reduce nitrate export from tile drainage flow, but its impact on phosphorus (P) loss is largely unknown. We compared P leaching from soil cores treated as free drainage (FD) or controlled drainage (CD) before and after manure application. In August 2012, 16 intact cores (45 cm long, 15 cm diameter) were collected from a grass forage field () located in Chazy, NY, and modified for drainage control and sampling. In Experiment 1 (no manure), initial leachate was defined as FD, and leachate collected 21 d later (valves closed) was considered CD...
January 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28177409/increased-soluble-phosphorus-loads-to-lake-erie-unintended-consequences-of-conservation-practices
#9
Helen P Jarvie, Laura T Johnson, Andrew N Sharpley, Douglas R Smith, David B Baker, Tom W Bruulsema, Remegio Confesor
Cumulative daily load time series show that the early 2000s marked a step-change increase in riverine soluble reactive phosphorus (SRP) loads entering the Western Lake Erie Basin from three major tributaries: the Maumee, Sandusky, and Raisin Rivers. These elevated SRP loads have been sustained over the last 12 yr. Empirical regression models were used to estimate the contributions from (i) increased runoff from changing weather and precipitation patterns and (ii) increased SRP delivery (the combined effects of increased source availability and/or increased transport efficiency of labile phosphorus [P] fractions)...
January 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28177133/dietary-supplementation-with-low-dose-omega-3-fatty-acids-reduces-salivary-tumor-necrosis-factor-%C3%AE-levels-in-patients-with-chronic-periodontitis-a-randomized-controlled-clinical-study
#10
I Keskiner, I Saygun, V Bal, M Serdar, A Kantarci
BACKGROUND AND OBJECTIVE: Recent studies have demonstrated the beneficial effects of omega-3 polyunsaturated fatty acids (PUFAs) on physiological processes and on a variety of chronic inflammatory diseases, including periodontal diseases. In this study, we evaluated the impact of omega-3 PUFAs in conjunction with scaling and root planing (SRP) on salivary markers in patients with chronic periodontitis. MATERIAL AND METHODS: Thirty systemically healthy subjects with chronic periodontitis were enrolled and randomly allocated into two groups...
February 8, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28169258/the-effect-of-indocyanine-green-mediated-photodynamic-therapy-as-an-adjunct-to-scaling-and-root-planing-in-the-treatment-of-chronic-periodontitis-a-comparative-split-mouth-randomized-clinical-trial
#11
Saurabh H Shingnapurkar, Dipika K Mitra, Mitali Suresh Kadav, Rohit A Shah, Silvia V Rodrigues, Saurabh S Prithyani
OBJECTIVE: The aim of this study was to assess the effect of adjunctive photodynamic therapy (PDT) (using 810 nm diode laser and Indocyanine green as photosensitizer) in chronic periodontitis. MATERIALS AND METHODS: Patients with untreated chronic periodontitis were included. Treatment was done according to a split mouth design. All sites received periodontal treatment comprising scaling and root-planing (SRP). Test group were additionally treated with PDT. Plaque Index (PI), Gingival Index (GI), Probing Pocket Depth (PPD) and Relative Attachment Level (RAL) were evaluated at baseline, 1 month and 3 months...
November 2016: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28164609/anti-cytoplasmic-autoantibodies-in-hodgkin-s-lymphoma
#12
Joachim Sennekamp, Hans-Peter Seelig
BACKGROUND: A 42-year old male patient with anamnesis of bronchial asthma presented himself with exertional dyspnea. High titer antibodies of cytoplasmic pattern in the indirect immunofluorescence test (IIFT) on HEp-2cells, not attributable to common specificities like anti-tRNA-synthetases, anti-signal recognition particle (SRP) or anti-ribosomal proteins (RPs) prompted the molecular biological approach for determination of antigen specificity. In-depth investigation of the patient's clinical settings revealed a lymphocyte predominant Hodgkin's lymphoma, which could be brought to complete remission by chemotherapy...
August 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28157192/unravelling-the-genetic-basis-of-simplex-retinitis-pigmentosa-cases
#13
Nereida Bravo-Gil, María González-Del Pozo, Marta Martín-Sánchez, Cristina Méndez-Vidal, Enrique Rodríguez-de la Rúa, Salud Borrego, Guillermo Antiñolo
Retinitis Pigmentosa (RP) is the most common form of inherited retinal dystrophy (IRD) characterized ultimately by photoreceptors degeneration. Exhibiting great clinical and genetic heterogeneity, RP can be inherited as an autosomal dominant (ad), autosomal recessive (ar) and X-linked (xl) disorder. Although the relative prevalence of each form varies somewhat between populations, a major proportion (41% in Spain) of patients represent simplex cases (sRP) in which the mode of inheritance is unknown. Molecular genetic diagnostic is crucial, but also challenging, for sRP patients because any of the 81 RP genes identified to date may be causative...
February 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28153399/changes-in-surface-water-chemistry-caused-by-natural-forest-dieback-in-an-unmanaged-mountain-catchment
#14
J Kopáček, H Fluksová, J Hejzlar, J Kaňa, P Porcal, J Turek
Ionic and nutrient compositions of throughfall, tributaries and lake outlet were analysed in the Plešné catchment-lake system (an unmanaged mountain forest in Central Europe) from 1997 to 2016. The aim was to evaluate changes in surface water chemistry after natural forest dieback. In the 2004-2008, 93% of the Norway spruce trees were killed by bark beetle outbreak, and all dead biomass remained in the catchment. Forest dieback changed the chemistry of all water fluxes, and the magnitude, timing, and duration of these changes differed for individual water constituents...
January 30, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28147577/exploiting-a-geometrically-sampled-grid-in-the-steered-response-power-algorithm-for-localization-improvement
#15
D Salvati, C Drioli, G L Foresti
The steered response power phase transform (SRP-PHAT) is a beamformer method very attractive in acoustic localization applications due to its robustness in reverberant environments. This paper presents a spatial grid design procedure, called the geometrically sampled grid (GSG), which aims at computing the spatial grid by taking into account the discrete sampling of time difference of arrival (TDOA) functions and the desired spatial resolution. A SRP-PHAT localization algorithm based on the GSG method is also introduced...
January 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28143946/cellular-proteomes-drive-tissue-specific-regulation-of-the-heat-shock-response
#16
Jian Ma, Christopher E Grant, Rosemary N Plagens, Lindsey N Barrett, Karen S Kim Guisbert, Eric Guisbert
The heat shock response (HSR) is a cellular stress response that senses protein misfolding and restores protein folding homeostasis, or proteostasis. We previously identified an HSR regulatory network in Caenorhabditis elegans consisting of highly conserved genes that have important cellular roles in maintaining proteostasis. Unexpectedly, the effects of these genes on the heat shock response are distinctly tissue-specific. Here, we explore this apparent discrepancy and find that muscle-specific regulation of the HSR by the TRiC/CCT chaperonin is not driven by an enrichment of TRiC/CCT in muscle, but rather by the levels of one of its most abundant substrates, actin...
January 30, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28140669/surgical-repositioning-of-the-premaxilla-using-a-minimally-invasive-endonasal-approach
#17
Nicolas E Sierra, Ada Ferrer-Fuertes, Bárbara Salazar-Perez, Gui-Youn Cho-Lee, Carles Martí-Pages, Alejandro Rivera-Baró, Josep Rubio Palau, Eloy M García-Diez
OBJECTIVE:   The aim of this study was to evaluate a technique for the surgical repositioning of the premaxilla using a minimally invasive endonasal approach. DESIGN:   Retrospective review of clinical records. SETTING:   Tertiary care, University Hospital, pediatric maxillofacial surgery unit. PATIENTS:   Twenty-one patients (12 boys and 9 girls), ages ranging from 6 to 21 years, with BCLP+A and premaxillary malposition (PM)...
January 31, 2017: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/28134917/the-signal-recognition-particle-contacts-ul23-and-scans-substrate-translation-inside-the-ribosomal-tunnel
#18
Kärt Denks, Nadine Sliwinski, Veronika Erichsen, Bogdana Borodkina, Andrea Origi, Hans-Georg Koch
The signal recognition particle (SRP) delivers ∼25% of all bacterial proteins to the membrane for cotranslational insertion. However, a comprehensive model on how the low-abundant SRP scans the vast number of translating ribosomes to identify the correct substrates is lacking. Here, we show that the C-terminal helix of the signal-sequence-binding domain of SRP penetrates into the ribosomal tunnel and contacts the intra-tunnel loop of ribosomal protein uL23. This allows SRP to obtain information about the translational status of the ribosome and possibly the character of the approaching nascent chain...
January 30, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28129347/the-celf1-rna-binding-protein-regulates-decay-of-signal-recognition-particle-mrnas-and-limits-secretion-in-mouse-myoblasts
#19
Joseph Russo, Jerome E Lee, Carolina M López, John Anderson, Thuy-Mi P Nguyen, Adam M Heck, Jeffrey Wilusz, Carol J Wilusz
We previously identified several mRNAs encoding components of the secretory pathway, including signal recognition particle (SRP) subunit mRNAs, among transcripts associated with the RNA-binding protein CELF1. Through immunoprecipitation of RNAs crosslinked to CELF1 in myoblasts and in vitro binding assays using recombinant CELF1, we now provide evidence that CELF1 directly binds the mRNAs encoding each of the subunits of the SRP. Furthermore, we determined the half-lives of the Srp transcripts in control and CELF1 knockdown myoblasts...
2017: PloS One
https://www.readbyqxmd.com/read/28128745/endothelial-dysfunction-microvascular-damage-and-ischemic-peripheral-vasculopathy-in-systemic-sclerosis
#20
Ivone Fernandes Santos da Silva, Andreia Teixeira, José Oliveira, Rui Almeida, Carlos Vasconcelos
OBJECTIVE: To evaluate endothelial dysfunction and microvascular damage in secondary Raynaud Phenomenon (SRP) and Systemic sclerosis (SSc)-associated patients as possible predictors of ischemic fingertip digital ulcers (DU) in a 3-year clinical follow-up. METHODS: Flow-mediated dilatation (FMD), nailfold videocapillaroscopy (NVC), endothelin-1 (ET-1) and asymmetric dimethylarginine (ADMA) were analysed in a 3-year observational cohort study of 77 SRP patients with systemic sclerosis...
January 27, 2017: Clinical Hemorheology and Microcirculation
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