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Epigallocatechin gallate

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https://www.readbyqxmd.com/read/29339972/evaluation-of-green-tea-extract-as-a-safe-personal-hygiene-against-viral-infections
#1
Yun Ha Lee, Yo Han Jang, Young-Seok Kim, Jinku Kim, Baik Lin Seong
Background: Viral infections often pose tremendous public health concerns as well as economic burdens. Despite the availability of vaccines or antiviral drugs, personal hygiene is considered as effective means as the first-hand measure against viral infections. The green tea catechins, in particular, epigallocatechin-3-gallate (EGCG), are known to exert potent antiviral activity. In this study, we evaluated the green tea extract as a safe personal hygiene against viral infections. Results: Using the influenza virus A/Puerto Rico/8/34 (H1N1) as a model, we examined the duration of the viral inactivating activity of green tea extract (GTE) under prolonged storage at various temperature conditions...
2018: Journal of Biological Engineering
https://www.readbyqxmd.com/read/29336144/nanostructured-peptidotoxins-as-natural-pro-oxidants-induced-cancer-cell-death-via-amplification-of-oxidative-stress
#2
Hongzhi Qiao, Dong Fang, Lei Zhang, Xiaochen Gu, Yin Lu, Minjie Sun, Chunmeng Sun, Qineng Ping, Junsong Li, Zhipeng Chen, Jun Chen, Lihong Hu, Liuqing Di
Melittin (Mel), one of the host defense peptides (HDPs) derived from venom of honeybees, demonstrates substantial anticancer properties, which is considered attributed to augmenting reactive oxygen species (ROS) generation. However, little has been reported on its pro-oxidation capacity in cancer oxidation therapy. In this study, a ROS amplifying nanodevice was fabricated through direct complexation of two natural pro-oxidants, Mel and condensed epigallocatechin gallate (pEGCG). The obtained nanocomplex (NC) was further covered with phenylboronic acid derivatized hyaluronic acid (pHA) through ROS-responsive boronate ester coordination bond to produce pHA-NC...
January 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29333044/antiplasmodial-activity-of-isolated-polyphenols-from-alectryon-serratus-leaves-against-3d7-plasmodium-falciparum
#3
Uswatun Khasanah, Aty WidyaWaruyanti, Achmad Fuad Hafid, Mulyadi Tanjung
Background: Alectryon serratus was selected from a screening program devoted to search naturally occurring antimalarial compound from plants in Alas Purwo National Park, Banyuwangi, East Java, Indonesia. The previous studies showed that ethanol extract of A. serratus leaves contains some polyphenol compounds. Objective: This study was designed to isolate and investigate antiplasmodial activity of polyphenol compounds. Material and Methods: The ethanol extract of A...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29332333/epigallocatechin-gallate-from-green-tea-exhibits-potent-anticancer-effects-in-a-549-non-small-lung-cancer-cells-by-inducing-apoptosis-cell-cycle-arrest-and-inhibition-of-cell-migration
#4
Jie Huang, Shi Chen, Yi Shi, Cheng-Hong Li, Xiao-Jiang Wang, Fa-Jiu Li, Chuan-Hai Wang, Qing-Hua Meng, Jin-Nan Zhong, Min Liu, Zi-Ming Wang
PURPOSE: Green tea (Camellia sinensis) is considered as a rich source of epigallocatechin gallate (EGCG) which has been shown to exert impressive pharmacological properties. The anticancer properties of EGCG have been extensively studied however, its anticancer activity has not been explored in lung cancer. The present study was therefore designed to evaluate the anticancer effects of EGCG against non-small cell lung cancer (NSCLC) cell line A-549 and normal human fibroblast FR-2 cells...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29316635/skin-protective-effect-of-epigallocatechin-gallate
#5
Eunji Kim, Kyeonghwan Hwang, Jongsung Lee, Sang Yun Han, Eun-Mi Kim, Junseong Park, Jae Youl Cho
Epigallocatechin gallate (EGCG) is a catechin and an abundant polyphenol in green tea. Although several papers have evaluated EGCG as a cosmetic constituent, the skin hydration effect of EGCG is poorly understood. We aimed to investigate the mechanism by which EGCG promotes skin hydration by measuring hyaluronic acid synthase (HAS) and hyaluronidase (HYAL) gene expression and antioxidant and anti-pigmentation properties using cell proliferation assay, Western blotting analysis, luciferase assay, 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, and reverse transcription polymerase chain reaction (RT-PCR) analysis...
January 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29310467/improved-anticancer-effects-of-epigallocatechin-gallate-using-rgd-containing-nanostructured-lipid-carriers
#6
Hamed Hajipour, Hamed Hamishehkar, Saeed Nazari Soltan Ahmad, Siamak Barghi, Nazila Fathi Maroufi, Ramezan Ali Taheri
The global burden of cancer have encouraged oncologists to develop novel strategies for treatment. Present study was proposed to develop Arginyl-glycyl-aspartic acid (RGD)-containing nanostructured lipid carriers (NLC) as a delivery system for improving the anticancer capability of epigallocatechin gallate (EGCG) on breast cancer cell line by attaching to integrin superfamily on cancer cells. For this purpose, RGD-containing EGCG-loaded NLC were prepared by hot homogenization technique and characterized by different techniques...
January 8, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29295524/dietary-copper-reduces-the-hepatotoxicity-of-epigallocatechin-3-gallate-in-mice
#7
Najeeb Ahmed Kaleri, Kang Sun, Le Wang, Jin Li, Wenzheng Zhang, Xuan Chen, Xinghui Li
We developed Cu-deficient, -sufficient and -super nutrition mice models by feeding them with diet containing 1.68, 11.72 or 51.69 mg of Cu/kg for 28 days, respectively. Then, the mice were treated to (-)-epigallocatechin-3-gallate (EGCG, 750 mg/kg BW) by oral in order to assess the acute toxicity of the drug. Following EGCG treatment, the survival rates were 12.5%, 50% and 100% in the Cu-deficient, -sufficient and Cu-super nutrition groups of mice, respectively. Cu level and ceruloplasmin activity in serum were significantly increased with the increase of dietary Cu...
December 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29290650/structural-shift-of-gut-microbiota-during-chemo-preventive-effects-of-epigallocatechin-gallate-on-colorectal-carcinogenesis-in-mice
#8
Xin Wang, Tao Ye, Wen-Jie Chen, You Lv, Zong Hao, Jun Chen, Jia-Ying Zhao, Hui-Peng Wang, Yuan-Kun Cai
AIM: To investigate the effect of epigallocatechin gallate (EGCG) on structural changes of gut microbiota in colorectal carcinogenesis. METHODS: An azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colitis mouse model was established. Forty-two female FVB/N mice were randomly divided into the following three groups: group 1 (10 mice, negative control) was treated with vehicle, group 2 (16 mice, positive control) was treated with AOM plus vehicle, and group 3 (16 mice, EG) was treated with AOM plus EGCG...
December 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29289576/botanicals-and-phytochemicals-active-on-cognitive-decline-the-clinical-evidence
#9
REVIEW
Arrigo F G Cicero, Federica Fogacci, Maciej Banach
Beyond the well-known effects on cognitive impairment of the Mediterranean diet, a number of studies have investigated the possible action on cognitive decline of different botanicals and phytochemicals, most of which are well-known anti-inflammatory or antioxidant agents with a good tolerability and safety profile. In particular, the current literature supports the use of Ginkgo biloba, resveratrol, epigallocatechin-3-gallate and l-theanine, Theobroma cacao, Bacopa monnieri, Crocus sativus and curcumin, which might have a positive impact on cognitive impairment used alone or in combination with other nutraceuticals or traditional drugs...
December 28, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29287393/effects-of-epigallocatechin-3-gallate-incorporation-on-the-physicochemical-and-oxidative-stability-of-myofibrillar-protein-soybean-oil-emulsions
#10
Yungang Cao, Nasi Ai, Alma D True, Youling L Xiong
The dose-dependent effects of (-)-epigallocatechin-3-gallate (EGCG; at 0, 50, 100, 200, 500, and 1000 mg/L) on the physical, chemical, and oxidative stability of porcine myofibrillar protein (MP)-soybean oil emulsion systems were investigated. The results showed EGCG at all levels effectively suppressed lipid oxidation in MP emulsion composite gels during the entire chill storage (at 4 °C for 0, 3, or 7 days). The incorporation of EGCG at higher concentrations (>100 mg/L) promoted the loss of sulfhydryls, reduction of surface hydrophobicity, and aggregation and cross-linking of MP...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29284973/successful-nonsurgical-management-of-periapical-lesions-of-endodontic-origin-a-conservative-orthograde-approach
#11
J V Karunakaran, Chris Susan Abraham, A Kaneesh Karthik, N Jayaprakash
Periapical lesions of endodontic origin are common pathological conditions affecting periradicular tissues. Microbial infection of pulpal tissues is primarily responsible for initiation and progression of apical periodontitis. The primary objective of endodontic therapy should be to restore involved teeth to a state of normalcy nonsurgically. Different nonsurgical management techniques, namely, conservative root canal therapy, decompression technique, method using calcium hydroxide, aspiration-irrigation technique, lesion sterilization and tissue repair therapy, active nonsurgical decompression technique, and the apexum procedure have been advocated...
November 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29279836/evaluation-of-endometrial-angiogenesis-in-mice-uterus-before-implantation-in-natural-cycles-followed-by-use-of-human-menopausal-gonadotropin-human-chorionic-gonadotropin-drugs-and-epigallocatechin-gallate
#12
Bahman Rashidi, Mehrnoush Malekzadeh
Background: Angiogenesis plays a major role in endometrial receptivity and thickening of the endometrium immediately before implantation. The aim of the present work was to evaluate the antiangiogenic properties of epigallocatechin-3-gallate (EGCG) from green tea in angiogenesis of endometrium. Materials and Methods: In this study, forty adult female NMARI mice randomly divided into four groups. Control group received vehicle; human menopausal gonadotropin/human chorionic gonadotropin (HMG/HCG) group received 7...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29278293/green-tea-polyphenol-egcg-alleviates-metabolic-abnormality-and-fatty-liver-by-decreasing-bile-acid-and-lipid-absorption-in-mice
#13
Jinbao Huang, Simin Feng, Anna Liu, Zhuqing Dai, Hong Wang, Kenneth Reuhl, Wenyun Lu, Chung S Yang
SCOPE: The tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) has been shown to ameliorate metabolic abnormalities and fatty liver. The present study investigated the mechanisms of actions of EGCG on bile acid homeostasis and lipid metabolism. METHODS: Male C57BL/6J mice were fed a low-fat diet, a high-fat western-style diet or a high-fat western-style diet containing 0.32% EGCG. The effects of the treatments on biochemical parameters, gene expression and lipidomics were analyzed...
December 26, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29276223/effects-of-epigallocatechin-3-gallate-on-egfr-or-fusion-gene-driven-lung-cancer-cells
#14
Yoshihiro Honda, Nagio Takigawa, Eiki Ichihara, Takashi Ninomiya, Toshio Kubo, Nobuaki Ochi, Masayuki Yasugi, Toshi Murakami, Hiromichi Yamane, Mitsune Tanimoto, Katsuyuki Kiura
No abstract text is available yet for this article.
December 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/29275296/effect-of-benifuuki-tea-on-cytochrome-p450-mediated-metabolic-activity-in-rats
#15
Takahito Hirai, Yuki Nishimura, Norimitsu Kurata, Hokuto Namba, Mariko Iwase, Yurika Gomi, Hiromichi Tsuchiya, Tomoyuki Yamakawa, Yuji Kiuchi
BACKGROUND/AIM: Benifuuki tea has recently been used as an alternative therapy for pollinosis, and it may be consumed with pharmaceutical drugs. This study aimed to examine cytochrome P450 (CYP)-mediated food-drug interactions with Benifuuki tea in rats. MATERIALS AND METHODS: The inhibitory effects of Benifuuki tea and (-)-epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3"Me) on CYP activities were evaluated in vitro. Midazolam pharmacokinetics was investigated after two treatments with Benifuuki tea...
January 2018: In Vivo
https://www.readbyqxmd.com/read/29273510/epigallocatechin-gallate-can-attenuate-human-alveolar-epithelial-cell-injury-induced-by-alpha-haemolysin
#16
Yonglin Zhou, Chengzhen Chen, Juan Pan, Xuming Deng, Jianfeng Wang
Staphylococcus aureus (S. aureus) is a common cause of hospital-acquired infection and has become an epidemic globally. Alpha-haemolysin (α-haemolysin), a pore-forming toxin, is one of the most important virulence factors secreted by most S. aureus strains. α-haemolysin monomers form a 232.4-kDa membrane-inserted heptamer by self-assembling to cause host cell lysis and death. Consequently, α-haemolysin plays a significant role in the pathogenesis of S. aureus, and it could be the target for the treatment of staphylococcal infection...
December 19, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29250041/stenotrophomonas-maltophilia-as-an-emerging-ubiquitous-pathogen-looking-beyond-contemporary-antibiotic-therapy
#17
REVIEW
Anthony A Adegoke, Thor A Stenström, Anthony I Okoh
Stenotrophomonas maltophilia is a commensal and an emerging pathogen earlier noted in broad-spectrum life threatening infections among the vulnerable, but more recently as a pathogen in immunocompetent individuals. The bacteria are consistently being implicated in necrotizing otitis, cutaneous infections including soft tissue infection and keratitis, endocarditis, meningitis, acute respiratory tract infection (RTI), bacteraemia (with/without hematological malignancies), tropical pyomyositis, cystic fibrosis, septic arthritis, among others...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29248449/interactions-between-crude-drug-extracts-used-in-japanese-traditional-kampo-medicines-and-organic-anion-transporting-polypeptide-2b1
#18
Rie Iijima, Tomoki Watanabe, Kan'ichiro Ishiuchi, Takashi Matsumoto, Junko Watanabe, Toshiaki Makino
ETHNOPHARMACOLOGICAL RELEVANCE: The use of herbal medicines has become popular worldwide, and the information on drug interactions between herbal medicines and chemical drugs is needed. AIM OF THE STUDY: We screened the inhibitory effects of crude drugs used in Kampo medicines used in Japan on organic anion-transporting polypeptide (OATP) 2B1 to predict potential interactions between Kampo medicines and chemical drugs used together. MATERIALS AND METHODS: We chose 98 kinds of crude drugs frequently used as ingredients of Kampo formulations in Japan and prepared their boiling water extracts...
December 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29247373/-epigallocatechin-3-gallate-the-major-green-tea-catechin-regulates-the-desensitization-of-%C3%AE-1-adrenoceptor-via-grk2-in-experimental-heart-failure
#19
Qi Zhang, Liqun Hu, Li Chen, Hongqi Li, Jun Wu, Wenting Liu, Mengyuan Zhang, Guang Yan
OBJECTIVE: We investigated the effect of (-)-epigallocatechin-3-gallate (EGCG) on cardiac function and its mechanism, which focused on the desensitization of β1-AR and GRK2 in heart failure (HF) rats. METHODS: HF was induced by abdominal aortic coarctation. Four weeks after HF induction, the rats were given EGCG (25, 50, 100 mg/kg/day). Cardiac function was assessed by measuring haemodynamic parameters. Histological changes were analyzed by HE and Masson's trichrome staining...
December 16, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29244739/metabolic-characterization-of-the-anthocyanidin-reductase-pathway-involved-in-the-biosynthesis-of-flavan-3-ols-in-elite-shuchazao-tea-camellia-sinensis-cultivar-in-the-field
#20
Lei Zhao, Xiao-Lan Jiang, Yu-Mei Qian, Pei-Qiang Wang, De-Yu Xie, Li-Ping Gao, Tao Xia
Anthocyanidin reductase (ANR) is a key enzyme in the ANR biosynthetic pathway of flavan-3-ols and proanthocyanidins (PAs) in plants. Herein, we report characterization of the ANR pathway of flavan-3-ols in Shuchazao tea (Camellia sinesis), which is an elite and widely grown cultivar in China and is rich in flavan-3-ols providing with high nutritional value to human health. In our study, metabolic profiling was preformed to identify two conjugates and four aglycones of flavan-3-ols: (-)-epigallocatechin-gallate [(-)-EGCG], (-)-epicatechin-gallate [(-)-ECG], (-)-epigallocatechin [(-)-EGC], (-)-epicatechin [(-)-EC], (+)-catechin [(+)-Ca], and (+)-gallocatechin [(+)-GC], of which (-)-EGCG, (-)-ECG, (-)-EGC, and (-)-EC accounted for 70-85% of total flavan-3-ols in different tissues...
December 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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