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Epigallocatechin gallate

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https://www.readbyqxmd.com/read/28432554/epigallocatechin-gallate-protects-beas-2b-cells-from-lipopolysaccharide-induced-apoptosis-through-upregulation-of-gastrin-releasing-peptide
#1
Peethambaran Divya, Bijesh Puthusseri, Denny Joseph Kollareth Manual, Mohammed Azharuddin Savanur
Gastrin-releasing peptide (GRP) plays a major role in the development and maintenance of lung epithelial cells by promoting cell division, whereas its suppression causes growth arrest and apoptosis. The present study shows that human bronchial epithelial BEAS-2B cells challenged with lipopolysaccharide (LPS), an endotoxin from gram-negative bacteria, downregulated GRP expression and induced apoptosis via upregulation of p53 and active caspase-3, signifying the importance of GRP in lung epithelial cell survival...
April 21, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28428085/galloylation-of-polyphenols-alters-their-biological-activity
#2
REVIEW
Daniel Karas, Jitka Ulrichová, Kateřina Valentová
Polyphenols form one of the largest groups of natural compounds and possess a wide range of biological properties. These activities can be influenced by the galloyl moiety within their structures. A multitude of galloylated polyphenolic compounds occurs in nature, but galloylated phenols are also produced synthetically to influence their biological properties. This review provides a comprehensive summary of current knowledge about natural (galloylated catechins, theaflavins and proanthocyanidins, penta-O-galloyl-β-D-glucose, gallotannins, ellagitannins, ellagic acid and flavonols) and semisynthetic gallates with a focus on their biological activity and toxicity issues...
April 17, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28428039/antimicrobial-mechanism-of-epigallocatechin-gallate-and-gallocatechin-gallate-they-target-1-deoxy-d-xylulose-5-phosphate-reductoisomerase-the-key-enzyme-of-the-mep-terpenoid-biosynthetic-pathway
#3
Xian Hui, Shui-Hong Hua, Qian-Qian Wu, Heng Li, Wen-Yun Gao
The catechins EGCG and GCG show a variety of pharmacological activities, especially an antibacterial capacity, but their modes of antimicrobial action have not been fully elucidated. 1-Deoxy-d-xylulose 5-phosphate reductoisomerase (DXR), the first key enzyme in the MEP pathway for terpenoid biosynthesis, is a recently validated antimicrobial target. In order to disclose the antibacterial mechanism of EGCG and GCG, the DXR inhibitory activity of them was investigated in this study. The data show that EGCG and GCG both could specifically suppress the activity of DXR, with EGCG exhibiting relatively low effect against DXR (IC50 about 210 μM) and GCG displaying strong activity (IC50 27...
April 17, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28424370/multi-site-binding-of-epigallocatechin-gallate-to-human-serum-albumin-measured-by-nmr-and-isothermal-calorimetry
#4
Joshua D Eaton, Mike P Williamson
The affinity of epigallocatechin gallate (EGCG) for human serum albumin was measured in physiological conditions using nuclear magnetic resonance (NMR) and isothermal titration calorimetry (ITC). NMR estimated the self-dissociation constant of EGCG as 50 mM. NMR showed two binding events: strong (n1 = 1.8 ± 0.2; Kd1 = 19 ± 12 μM), and weak (n2 ~ 20; Kd2 = 40 ± 20 mM). ITC also showed two binding events: strong (n1 = 2.5 ± 0.03; Kd1 = 21.6 ± 4.0 μM), and weak (n2 = 9 ± 1; Kd2 = 22 ± 4 mM). The two techniques are consistent, with an unexpectedly high number of bound EGCG...
April 19, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28423656/effect-of-y6-an-epigallocatechingallate-derivative-on-reversing-doxorubicin-drug-resistance-in-human-hepatocellular-carcinoma-cells
#5
Yan Wen, Rui-Qiang Zhao, Yun-Kai Zhang, Pranav Gupta, Li-Xiang Fu, An-Zhou Tang, Bu-Ming Liu, Zhe-Sheng Chen, Dong-Hua Yang, Gang Liang
Cancer cells can acquire resistance to a wide variety of diverse and unrelated drugs, this phenomenon is termed multidrug resistance (MDR). Multidrug resistance has been an obstacle to the success of cancer chemotherapy. The present study investigated the reversal effect of Y6, a new compound obtained by chemically modifying the structure of epigallocatechin-3-gallate (EGCG) extracted from green tea. Y6 was proven to be effective in inhibiting cell proliferation and reversing drug resistance in doxorubicin (DOX) resistant human hepatocellular carcinoma cells (BEL-7404/DOX)...
March 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28417981/reduced-prostate-cancer-risk-with-green-tea-and-epigallocatechin-3-gallate-intake-among-hong-kong-chinese-men
#6
P M Y Lee, C F Ng, Z M Liu, W M Ho, M K Lee, F Wang, H D Kan, Y H He, S S M Ng, S Y S Wong, L A Tse
BACKGROUND: In vitro and in vivo studies suggested that polyphenol epigallocatechin 3-gallate (EGCG) in tea may have anti-carcinogenic effect on prostate cells, but this protective effect has less been examined in epidemiology studies. We aimed to investigate the association between prostate cancer (PCA) risk and habitual green tea intake among Chinese men in Hong Kong; meanwhile, the relationship with EGCG was also explored. METHODS: We consecutively recruited 404 PCA cases and 395 controls from the same hospital who had complete data on habitual tea consumption, including green, oolong, black and pu'er tea...
April 18, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28416859/effect-of-catechin-and-its-derivatives-on-inhibition-of-polyphenoloxidase-and-melanosis-of-pacific-white-shrimp
#7
Thanasak Sae-Leaw, Soottawat Benjakul, Benjamin K Simpson
This study aimed to investigate the effect of tea catechin (C) and 4 of its derivatives on the Pacific white shrimp PPO inhibition and melanosis during refrigerated storage. Epigallocatechin gallate (EGCG) exhibited the highest inhibition towards PPO, followed by C. Inhibitory activity of all compounds tested was in a dose dependent manner (0.1-2.0 mM). Based on activity staining, EGCG most effectively inhibited PPO. For inhibition kinetic studies, C and epicatechin (EC) showed uncompetitive type, whereas epicatechin gallate (ECG), epigallocatechin (EGC) and EGCG exhibited mixed type inhibition...
April 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28412321/egcg-ameliorates-diet-induced-metabolic-syndrome-associating-with-the-circadian-clock
#8
Yashi Mi, Guoyuan Qi, Rong Fan, Xiaohua Ji, Zhigang Liu, Xuebo Liu
In response to the daily light-dark (LD) cycle, organisms on Earth have evolved with the approximately 24-h endogenous oscillations to coordinate behavioral and physiological processes, including feeding, sleep, and metabolism homeostasis. Circadian desynchrony triggered by an energy-dense diet rich in fats and fructose is intimately connected with a series of metabolic disorders. Previous studies revealed that (-)-Epigallocatechin-3-gallate (EGCG) could mitigate metabolic misalignment; however, only a few reports have focused on its potential effect on directly manipulating circadian rhythms to ameliorate metabolic syndrome...
April 12, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28411056/development-and-evaluation-of-resveratrol-vitamin-e-and-epigallocatechin-gallate-loaded-lipid-nanoparticles-for-skin-care-applications
#9
Jin Chen, Ning Wei, Maria Lopez-Garcia, Dianna Ambrose, Jason Lee, Colin Annelin, Teresa Peterson
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) have been studied as potential carriers for both dermal and transdermal drug delivery. SLN contain lipid droplets that are fully crystallized and have a highly-ordered crystalline structure. NLC are modified SLN in which the lipid phase contains both solid and liquid lipids at room temperature. SLN and NLC are thought to combine the advantages of polymeric particles, liposomes and emulsions. Therefore they provide high encapsulation percentages, better protection for incorporated actives and allow for control of desired release profile...
April 11, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28402019/epigallocatechin-gallate-inhibits-streptococcus-pneumoniae-virulence-by-simultaneously-targeting-pneumolysin-and-sortase%C3%A2-a
#10
Meng Song, Zihao Teng, Meng Li, Xiaodi Niu, Jianfeng Wang, Xuming Deng
Streptococcus pneumoniae (pneumococcus), the causative agent of several human diseases, possesses numerous virulence factors associated with pneumococcal infection and pathogenesis. Pneumolysin (PLY), an important virulence factor, is a member of the cholesterol-dependent cytolysin family and has cytolytic activity. Sortase A (SrtA), another crucial pneumococcal virulence determinate, contributes greatly to the anchoring of many virulence-associated surface proteins to the cell wall. In this study, epigallocatechin gallate (EGCG), a natural compound with little known antipneumococcal activity, was shown to directly inhibit PLY-mediated haemolysis and cytolysis by blocking the oligomerization of PLY and simultaneously reduce the peptidase activity of SrtA...
April 12, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28400479/a-presurgical-study-of-lecithin-formulation-of-green-tea-extract-in-women-with-early-breast-cancer
#11
Matteo Lazzeroni, Aliana Guerrieri-Gonzaga, Sara Gandini, Harriet Johansson, Davide Serrano, Massimiliano Cazzaniga, Valentina Aristarco, Debora Macis, Serena Mora, Pietro Caldarella, Gianmatteo Pagani, Giancarlo Pruneri, Antonella Riva, Giovanna Petrangolini, Paolo Morazzoni, Andrea DeCensi, Bernardo Bonanni
Epidemiologic data support an inverse association between green tea intake and breast cancer risk. Greenselect®Phytosome® (GSP) is a lecithin formulation of a caffeine-free green tea catechin extract. The purpose of the study was to determine the tissue distribution of Epigallocatechin-3-O-gallate (EGCG) and its effect on cell proliferation and circulating biomarkers in breast cancer patients. Twelve early BC patients received GSP 300 mg, equivalent to 44.9 mg of EGCG, daily for 4 weeks prior to surgery. The EGCG levels were measured before (free-) and after (total-) enzymatic hydrolysis by HPLC-MS/MS in plasma, urine, breast cancer tissue and surrounding normal breast tissue...
April 11, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28394429/possible-use-of-epigallocatechin-3-gallate-egcg-as-prevention-of-radio-dermatitis-in-radiotherapy-treated-breast-cancer-patients
#12
Massimo Bonucci, Massimo Fioranelli, Maria Grazia Roccia, Torello Lotti
No abstract text is available yet for this article.
April 10, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28393248/epigallocatechin-3-gallate-ameliorates-insulin-resistance-in-hepatocytes
#13
Shan-Bo Ma, Rui Zhang, Shan Miao, Bin Gao, Yang Lu, Sen Hui, Long Li, Xiao-Peng Shi, Ai-Dong Wen
Hyperglycemia is a typical pathogenic factor in a series of complications among patients with type II diabetes. Epigallocatechin-3-gallate (EGCG) is the major polyphenol extracted from green tea and is reported to be an antioxidant. The aim of the present study was to examine the effect of EGCG on insulin resistance in human HepG2 cells pretreated with high concentrations of glucose. The protein kinase B (AKT)/glycogen synthase kinase (GSK) pathways were analyzed using western blot analysis in HepG2 cells and primary mouse hepatocytes treated with high glucose and/or EGCG...
April 7, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28389416/cell-surface-grp78-facilitates-hepatoma-cells-proliferation-and-migration-by-activating-igf-ir
#14
Yancun Yin, Chen Chen, Jinliang Chen, Renhui Zhan, Qiang Zhang, Xiaoyan Xu, Defang Li, Minjing Li
The 78kDa glucose regulated protein (GRP78) is a multifunctional chaperone that is involved in a variety of cellular processes. Insulin like growth factor I receptor (IGF-IR) often aberrant expresses in many types of tumor cells. The IGF-IR signaling plays key roles in carcinogenesis and maintenance of the malignant phenotype. The crosstalk between GRP78 and IGF-IR molecules has not well been illuminated. Here, we demonstrated a reciprocal regulation of GRP78 expression and IGF-IR pathway activation. IGF-I induced GRP78 expression in hepatoma cells...
April 4, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28382690/epigallocatechin-gallate-reverses-ctni-low-expression-induced-age-related-heart-diastolic-dysfunction-through-histone-acetylation-modification
#15
Bo Pan, Junjun Quan, Lingjuan Liu, Zhongwei Xu, Jing Zhu, Xupei Huang, Jie Tian
Cardiac diastolic dysfunction (CDD) is the most common form of cardiovascular disorders, especially in elderly people. Cardiac troponin I (cTnI) plays a critical role in the regulation of cardiac function, especially diastolic function. Our previous studies showed that cTnI-low expression induced by histone acetylation modification might be one of the causes that result in diastolic dysfunction in ageing hearts. This study was designed to investigate whether epigallocatechin-3-gallate (EGCG) would modify histone acetylation events to regulate cTnI expression and then improve cardiac functions in ageing mice...
April 6, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28377597/dyrk1a-overexpression-leads-to-increase-of-3r-tau-expression-and-cognitive-deficits-in-ts65dn-down-syndrome-mice
#16
Xiaomin Yin, Nana Jin, Jianhua Shi, Yanchong Zhang, Yue Wu, Cheng-Xin Gong, Khalid Iqbal, Fei Liu
Alternative splicing of tau exon 10 generates tau isoforms with three or four microtubule-binding repeats, 3R-tau and 4R-tau, which is equally expressed in adult human brain. Imbalanced expression in 3R-tau and 4R-tau has been found in several sporadic and inherited tauopathies, suggesting that dysregulation of tau exon 10 is sufficient to cause neurodegenerative diseases. We previously reported that Dyrk1A, which is overexpressed in Down syndrome brains, regulates alternative splicing of exogenous tau exon 10...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28367625/epigallocatechin-3-gallate-reduces-scavenger-receptor-a-expression-and-foam-cell-formation-in-human-macrophages
#17
Sy-Jou Chen, Yung-Hsi Kao, Li Jing, Yi-Ping Chuang, Wan-Lin Wu, Shu-Ting Liu, Shih-Ming Huang, Jenn-Haung Lai, Ling-Jun Ho, Min-Chien Tsai, Chin-Sheng Lin
Foam cells are formed when macrophages imbibe low-density lipoprotein (LDL) through scavenger receptors. Here we examined how epigallocatechin-3-gallate (EGCG) influences foam cell formation. We found that EGCG dose-dependently reduced oxidized LDL (oxLDL) uptake in THP-1 (10 μM, 20.0 ± 0.50, p < 0.05) and primary macrophages (134.6 ± 15.6, p < 0.05) and reduced intracellular cholesterol content in these cells, respectively (10 μM, 32.6 ± 0.14, p < 0.05; 31.7 ± 1.26, p < 0.05). EGCG treatment decreased scavenger receptor A expression, but not the expression of CD36 or of reverse cholesterol transporters...
April 10, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28365685/-epigallocatechin-3-gallate-inhibits-arsenic-induced-inflammation-and-apoptosis-through-suppression-of-oxidative-stress-in-mice
#18
Nan-Hui Yu, Haiping Pei, Yong-Pan Huang, Yu-Fei Li
BACKGROUND/AIMS: Exposure to arsenic in individuals has been found to be associated with various health-related problems including skin lesions, cancer, and cardiovascular and immunological disorders. (-)-Epigallocatechin-3-gallate (EGCG), the main and active polyphenolic catechin present in green tea, has shown potent antioxidant, anti-apoptotic and anti-inflammatory activity in vivo and in vitro. Thus, the present study was conducted to investigate the protective effects of EGCG against arsenic-induced inflammation and immunotoxicity in mice...
April 3, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28361543/inhibition-of-myeloperoxidase-and-neutrophil-mediated-hypochlorous-acid-formation-in-vitro-and-endothelial-cell-injury-by-epigallocatechin-gallate
#19
Rong Tian, Yun Ding, Yi-Yuan Peng, Naihao Lu
Myeloperoxidase (MPO) plays important roles in various diseases through its unique chlorinating activity to catalyze excess hypochlorous acid (HOCl) formation. Epidemiological studies indicate an inverse correlation between plant polyphenol consumption and the incidence of cardiovascular diseases. Here we showed that (-)-epigallocatechin gallate (EGCG), the main flavonoid present in green tea, dose-dependently inhibited MPO-mediated HOCl formation in vitro (chlorinating activities of MPO: 50.2 ± 5.7% for 20 μM EGCG versus 100 ± 5...
April 10, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28357648/ameliorated-effects-of-epigallocatechin-gallate-against-toxicity-induced-by-vanadium-in-the-kidneys-of-wistar-rats
#20
Ahlem Soussi, Raed Abdennabi, Fatma Ghorbel, Jean-Claude Murat, Abdel Fettah El Feki
The aim of the study was to assess the protective effect of (-)-epigallocatechin gallate (EGCG), a flavonoid abundant in green tea, against ammonium metavanadate (AMV)-induced oxidative stress in male Wistar rats. Four groups of animals have been used, a control group and three test groups. In the first test group, AMV was intra-peritoneally (i.p) injected daily (5 mg/kg body weight for five consecutive days). The second test group of animals was also injected daily with EGCG (5 mg/kg body weight) during the same period...
March 29, 2017: Biological Trace Element Research
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