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Epigallocatechin gallate

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https://www.readbyqxmd.com/read/28635075/salts-influence-cathechins-and-flavonoids-encapsulation-in-liposomes-a-molecular-dynamics-investigation
#1
Emiliano Laudadio, Giovanna Mobbili, Cristina Minnelli, Luca Massaccesi, Roberta Galeazzi
Cathechins and flavonoids are responsible of numerous health benefits. Two of the most representatives' compounds for their antioxidant and therapeutic effects are Epigallocatechin 3-Gallate (EGCG), from green tea extracts, and morelloflavone (MF), from Garcinia dulcis. Here we explore, by atomistic Molecular Dynamics simulations, how EGCG and MF interact with lipid bilayers and we show the salts' influence on their encapsulation degree in neutral liposomes. As a result, we found out that EGCGs naturally bind to the hydrophilic regions of phospholipids, positioning themselves mostly at the interface between water and lipid phases...
June 21, 2017: Molecular Informatics
https://www.readbyqxmd.com/read/28633380/epigallocatechin-3-gallate-and-related-phenol-compounds-redirect-the-amyloidogenic-aggregation-pathway-of-ataxin-3-towards-non-toxic-aggregates-and-prevent-toxicity-in-neural-cells-and-caenorhabditis-elegans-animal-model
#2
Cristina Visentin, Francesca Pellistri, Antonino Natalello, Jacopo Vertemara, Marcella Bonanomi, Elena Gatta, Amanda Penco, Annalisa Relini, Luca De Gioia, Cristina Airoldi, Maria E Regonesi, Paolo Tortora
The protein ataxin-3 (ATX3) triggers an amyloid-related neurodegenerative disease when its polyglutamine stretch is expanded beyond a critical threshold. We formerly demonstrated that the polyphenol epigallocatechin-3-gallate (EGCG) could redirect amyloid aggregation of a full-length, expanded ATX3 (ATX3-Q55) towards non-toxic, soluble, SDS-resistant aggregates. Here, we have characterized other related phenol compounds, although smaller in size, i.e., (-)-epigallocatechin gallate (EGC), and gallic acid (GA)...
June 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28628342/effect-of-green-tea-polyphenol-epigallocatechin-3-gallate-on-the-aggregation-of-%C3%AE-a-66-80-peptide-a-major-fragment-of-%C3%AE-a-crystallin-involved-in-cataract-development
#3
Vijay Kumar, Shalini Gour, Ocan Simon Peter, Shraddha Gandhi, Pankaj Goyal, Janmejay Pandey, Ram Swaroop Harsolia, Jay Kant Yadav
PURPOSE: Crystallin is a major protein present in eye lens. Peptide fragment αA(66-80) derived from αA-crystallin possesses high aggregation propensity and forms amyloid-like structures. αA(66-80) aggregates are known to interact with soluble crystallins and destabilize native structures that subsequently undergo aggregation. Crystallin aggregation in eye lens leads to reduction in lens opacity, the condition generally referred to as a cataract. Thus, αA(66-80) aggregation appears to be an important event during cataract development, and therefore, inhibition of αA(66-80) aggregation may be an attractive strategy to intervene in cataract development...
June 19, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28627733/response-of-renal-tubular-cells-to-differential-types-and-doses-of-calcium-oxalate-crystals-integrative-proteome-network-analysis-and-functional-investigations
#4
Arada Vinaiphat, Siripat Aluksanasuwan, Juthatip Manissorn, Suchitra Sutthimethakorn, Visith Thongboonkerd
We have previously identified changes in the cellular proteome of renal tubular cells induced by low-dose (100 μg/ml) and high-dose (1,000 μg/ml) calcium oxalate monohydrate (COM) and dihydrate (COD) crystals. However, the functional significance of such expression data remained unclear. In this study, we performed comparative analyses and functional investigations of four proteomic datasets to define potential mechanisms by which renal tubular cells responded to differential crystal types and doses. The data showed that high-dose induced greater changes than low-dose, whereas COM induced more changes than COD...
June 19, 2017: Proteomics
https://www.readbyqxmd.com/read/28627636/formulation-and-characterization-of-egcg-for-the-treatment-of-superficial-bladder-cancer
#5
Katarzyna Dettlaff, Maciej Stawny, Magdalena Ogrodowczyk, Anna Jelińska, Waldemar Bednarski, Dorota Wątróbska-Świetlikowska, Rick W Keck, Omar A Khan, Ibrahim H Mostafa, Jerzy Jankun
In the United States, the annual incidence of bladder cancer is approximately 70,000 new cases, with a mortality rate of approximately 15,000/year. The most common subtype (70%) of bladder cancer is superficial, namely hte non-muscle invasive disease form limited to the urothelium. The rate of progression and recurrence is up to 40 and 70%, respectively. Urothelial cell carcinoma of the bladder is typically treated with transurethral resection. The cancerous cells can float onto the adjacent epithelium, increasing the risk of recurrence...
June 14, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28622550/effect-of-gels-containing-chlorhexidine-or-epigallocatechin-3-gallate-on-the-protein-composition-of-the-acquired-enamel-pellicle
#6
Cíntia Maria de Souza-E-Silva, Talita Mendes da Silva Ventura, Luiza de Pau, la Silva Cassiano, Aline de Lima Leite, Marília Afonso Rabelo Buzalaf
OBJECTIVE: This study evaluated changes in protein profile of the acquired enamel pellicle (AEP) formed in vivo, after application of gels containing chlorhexidine or EGCG and further challenge with citric acid. DESIGN: AEP was formed in 9 volunteers for 2h and then treated with one of the following gels: placebo, 400μM EGCG or 0.012% chlorhexidine. A thin layer of gel was applied and after 1min the excess was removed. One hour after gel application, the AEP was collected from the buccal surface (upper and lower jaw) of one of the sides with filter paper dipped in 3% citric acid...
June 3, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28619693/oral-astringent-stimuli-alter-the-enamel-pellicle-s-ultrastructure-as-revealed-by-electron-microscopy
#7
Melanie Rehage, Judith Delius, Thomas Hofmann, Matthias Hannig
OBJECTIVES: This electron microscopic study aimed at investigating effects of oral astringent stimuli on the enamel pellicle's morphology. METHODS: Pellicles were formed in situ within 30min on bovine enamel slabs, fixed to individuals' upper jaw splints. The pellicle-coated specimens were immersed in vitro in seven diverse astringent solutions and subsequently analyzed by scanning electron microscopy (SEM), energy dispersive X-ray (EDX) spectroscopy, as well as transmission electron microscopy (TEM)...
June 12, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28612587/%C3%A2-menthol-induces-reversal-of-promoter-hypermethylation-and-associated-up-regulation-of-the-fancf-gene-in-the-siha-cell-line
#8
Gaurav Parashar, Nidarshana Chaturvedi Parashar, Neena Capalash
Objective: To identify natural bioactive molecules with potential to inhibit DNA methyltransferase 1 (DNMT1) and cause reactivation of genes silenced due to promoter hypermethylation. Methods and Results: -(-) Menthol and epigallocatechin-3-gallate (EGCG) (reference molecule) were investigated using an in vitro methylation assay, which indicated potential of –(-)menthol as an epigenetic modulator with the ability to directly inhibit M.SssI (an analogue of DNMT1) activity at 100μM. Methylation specific PCR and bisulphite sequencing revealed complete hypomethylation of 15 CpG sites in the Fanconi anemia, complementation group F (FANCF) gene between +280 and + 432 nucleotides relative to the transcription start site, which resulted in significant (P<0...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28611670/identification-of-epigallocatechin-3-gallate-as-an-inhibitor-of-phosphoglycerate-mutase-1
#9
Xiaoguang Li, Shuai Tang, Qian-Qian Wang, Elaine L-H Leung, Hongyue Jin, Yongzhuo Huang, Jia Liu, Meiyu Geng, Min Huang, Shengtao Yuan, Xiao-Jun Yao, Jian Ding
Targeting metabolic enzymes is believed to provide new therapeutic opportunities for cancer therapy. Phosphoglycerate mutase 1 (PGAM1) is a glycolytic enzyme that importantly coordinates glycolysis, pentose phosphate pathway (PPP) flux and serine biosynthesis in cancer cells and hence gains increasing interest of inhibitor discovery. Only few PGAM1 inhibitors have been reported and the molecular potency remains very limited. In an effort to discover new PGAM1 inhibitors, we carried out a biochemical assay-based screen that was focused on natural products derived small molecule compounds...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28605495/green-tea-and-epigallocatechin-3-gallate-are-bactericidal-against-bacillus-anthracis
#10
Shane D Falcinelli, Maggie C Shi, Arthur M Friedlander, Jennifer Chua
Bacillus anthracis, the etiological agent of anthrax, is listed as a Category A biothreat agent by the United States Centers for Disease Control and Prevention. The virulence of the organism is due to expression of two exotoxins and capsule, which interfere with host cellular signaling, alter host water homeostasis, and inhibit phagocytosis of the pathogen, respectively. Concerns regarding the past and possible future use of B. anthracis as a bioterrorism agent have resulted in an impetus to develop more effective protective measures and therapeutics...
June 12, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28603626/physiologically-based-pharmacokinetic-modeling-of-tea-catechin-mixture-in-rats-and-humans
#11
Francis C P Law, Meicun Yao, Hui-Chang Bi, Stephen Lam
Although green tea (Camellia sinensis) (GT) contains a large number of polyphenolic compounds with anti-oxidative and anti-proliferative activities, little is known of the pharmacokinetics and tissue dose of tea catechins (TCs) as a chemical mixture in humans. The objectives of this study were to develop and validate a physiologically based pharmacokinetic (PBPK) model of tea catechin mixture (TCM) in rats and humans, and to predict an integrated or total concentration of TCM in the plasma of humans after consuming GT or Polyphenon E (PE)...
June 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28602600/influence-of-the-dual-combination-of-silymarin-and-epigallocatechin-gallate-natural-dietary-flavonoids-on-the-pharmacokinetics-of-oxcarbazepine-in-rats
#12
Ana Ferreira, Márcio Rodrigues, Alexandre Marques, Amílcar Falcão, Gilberto Alves
Considering the potential of flavonoids in reversing the P-glycoprotein (P-gp)-mediated multidrug resistance, this work aimed to assess the combined effects of silymarin and (-)-epigallocatechin gallate (EPG) on the pharmacokinetics of the P-gp substrates oxcarbazepine (OXC) and licarbazepine (LIC). Rats were pre-treated intraperitoneally with silymarin (25 mg/kg), EPG (25 mg/kg), silymarin/EPG (12.5/12.5 mg/kg; 6.25/18.75 mg/kg; 18.75/6.25 mg/kg) or verapamil (25 mg/kg, reference P-gp inhibitor) before the intraperitoneal administration of OXC (50 mg/kg)...
June 8, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28600977/targeting-epithelial-mesenchymal-transition-metal-organic-network-nano-complexes-for-preventing-tumor-metastasis
#13
Jin-Xuan Fan, Di-Wei Zheng, Lei Rong, Jing-Yi Zhu, Sheng Hong, Cao Li, Zu-Shun Xu, Si-Xue Cheng, Xian-Zheng Zhang
Tumor metastasis is the leading cause of death in cancer patients, and epithelial-mesenchymal transition (EMT) is an essential step in tumor metastasis. Unfortunately, during the chemotherapy, EMT could be induced under the selective pressure of clinical cytotoxic drugs. Here, to solve this problem, we have synthesized multi-functional epigallocatechin gallate/iron nano-complexes (EIN) as a versatile coating material to improve conventional therapies. In vitro studies showed that this strategy could eliminate EMT-type cancer cells...
September 2017: Biomaterials
https://www.readbyqxmd.com/read/28597441/accumulation-of-catechins-and-expression-of-catechin-synthetic-genes-in-camellia-sinensis-at-different-developmental-stages
#14
Li-Qun Zhang, Kang Wei, Hao Cheng, Li-Yuan Wang, Cheng-Cai Zhang
BACKGROUND: Catechins are the main polyphenol compounds in tea (Camellia sinensis). To understand the relationship between gene expression and product accumulation, the levels of catechins and relative expressions of key genes in tea leaves of different developmental stages were analyzed. RESULTS: The amounts of catechins differed significantly in leaves of different stages, except for gallocatechin gallate. Close correlations between the expression of synthesis genes and the accumulation of catechins were identified...
December 2016: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/28589947/gut-microbiota-composition-in-relation-to-the-metabolic-response-to-12-week-combined-polyphenol-supplementation-in-overweight-men-and-women
#15
J Most, J Penders, M Lucchesi, G H Goossens, E E Blaak
BACKGROUND/OBJECTIVES: The intestinal microbiota may have a profound impact on host metabolism. As evidence suggests that polyphenols affect substrate utilization, the present study aimed to investigate the effects of polyphenol supplementation on intestinal microbiota composition in humans. Furthermore, we examined whether (changes in) gut microbiota composition may determine the metabolic response to polyphenol supplementation. SUBJECTS/METHODS: In this randomized, double-blind, placebo (PLA)-controlled trial, 37 overweight and obese men and women (18 males/19 females, 37...
June 7, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28587207/-epigallocatechin-3-gallate-inhibits-colorectal-cancer-stem-cells-by-suppressing-wnt-%C3%AE-catenin-pathway
#16
Yue Chen, Xiao-Qian Wang, Qi Zhang, Jian-Yun Zhu, Yuan Li, Chun-Feng Xie, Xiao-Ting Li, Jie-Shu Wu, Shan-Shan Geng, Cai-Yun Zhong, Hong-Yu Han
The beneficial effects of tea consumption on cancer prevention have been generally reported, while (-)-Epigallocatechin-3-gallate (EGCG) is the major active component from green tea. Cancer stem cells (CSCs) play a crucial role in the process of cancer development. Targeting CSCs may be an effective way for cancer intervention. However, the effects of EGCG on colorectal CSCs and the underlying mechanisms remain unclear. Spheroid formation assay was used to enrich colorectal CSCs from colorectal cancer cell lines...
June 3, 2017: Nutrients
https://www.readbyqxmd.com/read/28587155/dietary-intervention-by-phytochemicals-and-their-role-in-modulating-coding-and-non-coding-genes-in-cancer
#17
REVIEW
Liviuta Budisan, Diana Gulei, Oana Mihaela Zanoaga, Alexandra Iulia Irimie, Chira Sergiu, Cornelia Braicu, Claudia Diana Gherman, Ioana Berindan-Neagoe
Phytochemicals are natural compounds synthesized as secondary metabolites in plants, representing an important source of molecules with a wide range of therapeutic applications. These natural agents are important regulators of key pathological processes/conditions, including cancer, as they are able to modulate the expression of coding and non-coding transcripts with an oncogenic or tumour suppressor role. These natural agents are currently exploited for the development of therapeutic strategies alone or in tandem with conventional treatments for cancer...
June 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28582855/diabetes-and-alzheimer-s-disease-can-tea-phytochemicals-play-a-role-in-prevention
#18
Fernando W M A D Binosha, Geeshani Somaratne, Shehan Williams, Kathryn G Goozee, Harjinder Singh, Ralph N Martins
Dementia and diabetes mellitus are prevalent disorders in the elderly population. While recognized as two distinct diseases, diabetes has more recently recognized as a significant contributor to risk for developing dementia, and some studies make reference to type 3 diabetes, a condition resulting from insulin resistance in the brain. Alzheimer's disease, the most common form of dementia, and diabetes, interestingly, share underlying pathological processes, commonality in risk factors, and, importantly, pathways for intervention...
May 30, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28579831/the-regulation-of-steroid-receptors-by-epigallocatechin-3-gallate-in-breast-cancer-cells
#19
Kelly Hallman, Katie Aleck, Meghan Quigley, Brigitte Dwyer, Victoria Lloyd, Monica Szmyd, Sumi Dinda
It has been reported that phytoestrogen epigallocatechin gallate (EGCG) suppresses cancer cell proliferation and may have antitumor properties. In this study, we analyzed the effects of EGCG on estrogen receptor α (ERα) and progesterone receptor in hormone-dependent T-47D breast cancer cells. Western blot analysis revealed EGCG induced a concentration-dependent decrease in ERα protein levels, with a 56% reduction occurring with 60 µM EGCG when compared to controls. Downregulation of ERα protein levels was observed after 24-hour co-treatment of T-47D cells with 60 µM EGCG and 10 nM 17β-estradiol (E2)...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28578967/preparation-and-characterization-of-antioxidant-edible-chitosan-films-incorporated-with-epigallocatechin-gallate-nanocapsules
#20
Jin Liang, Hua Yan, Jiuya Zhang, Wenzhong Dai, Xueling Gao, Yibin Zhou, Xiaochun Wan, Pradeep Puligundla
Antioxidant edible films based on chitosan hydrochloride (CHC) and epigallocatechin gallate (EGCG)-loaded nanocapsules (NCs) were developed. The CHC films incorporated with NCs were prepared by a casting method in three different proportions. The obtained films were characterized using the techniques including scanning electron microscopy, Fourier transform infrared spectroscopy and X-ray diffraction. Meanwhile, the mechanical and color properties, optical transmittance, EGCG release profile and antioxidant activity were also determined...
September 1, 2017: Carbohydrate Polymers
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